LOCUS       c00016_gnlPro..        13087 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|AFKGDBHA_16.
ACCESSION   c00016_gnlPro..
VERSION     c00016_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-06 01:58:20
            Original ID  :: gnl|Prokka|AFKGDBHA_16
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 13087
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..13087
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[2519:7228]"
                     /cutoff="10000"
                     /detection_rule="(minimum(4, [AcetylCoA_hyd_C,
                     AcetylCoA_hydro, B12-binding, Biotin_lipoyl, Glyoxalase_4,
                     HMGL-like, MM_CoA_mutase, MeaB, OAD_beta, OAD_gamma,
                     PYC_OADA]) and minimum(1, [CT_Btheta, CT_Propionyl_CoA1,
                     CT_Propionyl_CoA2, CT_Propionyl_CoA3, CT_Vparvula]) and not
                     Cytidylate_kin)"
                     /neighbourhood="10000"
                     /product="succinate2propionate"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      2520..7228
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(minimum(4, [AcetylCoA_hyd_C,
                     AcetylCoA_hydro, B12-binding, Biotin_lipoyl, Glyoxalase_4,
                     HMGL-like, MM_CoA_mutase, MeaB, OAD_beta, OAD_gamma,
                     PYC_OADA]) and minimum(1, [CT_Btheta, CT_Propionyl_CoA1,
                     CT_Propionyl_CoA2, CT_Propionyl_CoA3, CT_Vparvula]) and not
                     Cytidylate_kin)"
                     /neighbourhood="10000"
                     /product="succinate2propionate"
                     /protocluster_number="1"
     cand_cluster    1..13087
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(minimum(4, [AcetylCoA_hyd_C,
                     AcetylCoA_hydro, B12-binding, Biotin_lipoyl, Glyoxalase_4,
                     HMGL-like, MM_CoA_mutase, MeaB, OAD_beta, OAD_gamma,
                     PYC_OADA]) and minimum(1, [CT_Btheta, CT_Propionyl_CoA1,
                     CT_Propionyl_CoA2, CT_Propionyl_CoA3, CT_Vparvula]) and not
                     Cytidylate_kin)"
                     /kind="single"
                     /product="succinate2propionate"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..13087
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="succinate2propionate"
                     /region_number="1"
                     /rules="(minimum(4, [AcetylCoA_hyd_C, AcetylCoA_hydro,
                     B12-binding, Biotin_lipoyl, Glyoxalase_4, HMGL-like,
                     MM_CoA_mutase, MeaB, OAD_beta, OAD_gamma, PYC_OADA]) and
                     minimum(1, [CT_Btheta, CT_Propionyl_CoA1,
                     CT_Propionyl_CoA2, CT_Propionyl_CoA3, CT_Vparvula]) and not
                     Cytidylate_kin)"
                     /tool="gutsmash"
     CDS             complement(33..887)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Alpha-amylase"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg16_1"
                     /sec_met_domain="Alpha-amylase (E-value: 3.5e-39, bitscore:
                     124.7, seeds: 19, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKKVFLILGTLLLSLSTYAAMNVNKIDPPFWYTGMQNPELQLMVY
                     GEGIGNAAVSVNYPGVSLSSTVKLESNNYLLVYLKLDKDVKPGKFNLTFTEGKKKLVKE
                     YELKARNKKGCEHKGFDASDALYLLMPDRFANGNPDNDQIAGMAEYKIDRNDPNARHGG
                     DLAGIEQHLDYFSNLGVTALWFTPVLENNMTGGSYHGYATTDYYKVDPRFGTNEEYKQL
                     IEKAHARGIKIVMDMIFNHCGVEHVWIKDMPSKDWFNNPDHENNFVQTSFKLTPHVDPY
                     TSQ"
     CDS             complement(998..2350)
                     /locus_tag="ctg16_2"
                     /transl_table=11
                     /translation="MRKLFISLCFSACCSLLAAQTTNPIQEAMANYDYETALMLIDQET
                     PTVPLLYQKGKALKGLGNNLEALSVFQEVVAQDSLNPRAYIEAAECCKSLAKYSEALDY
                     YQNALHINPDNKYARIQYISLLMNMKRYRESLKESNLLAERDSSAYVLHLRAESMGQVY
                     DNTEIMHVIDAYLDIQKRYPNDYLSAAKLGNIYVAGHQYEDAINITEKYRSIDSTNVLV
                     NRINAQAYCLNKDYPKAIERYEQLLQEKDSSFQTCFYAGISYYALEDFYPAHDLLERAL
                     KDDNTNINVLYYLGRACSKTSWKEDGVTYLETAVSLAMPSDSVMSRLYVGLADCYKMAF
                     QYTDQANTLLTQYEKYDRQKHKLLYDAAFIYYYYLKDASKAERYLTAYLKTRPKNSKDK
                     VQEVDADGVPIIGEDNRYNAAENWLKDIREKRKKEDFFKGKVDTASVTPIK"
     CDS             complement(2520..3680)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: OAD_beta"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg16_3"
                     /sec_met_domain="OAD_beta (E-value: 4.3e-153, bitscore:
                     498.9, seeds: 229, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MGEFITFLGNNLADFWTYTGFANATVGHVVMLLVGLFFIYLAVAK
                     EFEPMLLIPIGFGMLIGNIPFNMEAGLKVGIYEEGSVLNILYQGVTSGWYPPLIFLGIG
                     AMTDFSALISNPKLMLVGAAAQFGIFGAYMIALAIGFDPMQAGAIGIIGGADGPTAIFL
                     SSKLAPNLMGAIAVSAYSYMALVPVIQPPIMRWLTSKNERLIRMKPPRVVSHTEKVMFP
                     IIGLLLTTFLVPSGLPLLGMLFFGNLLKESGVTRRLANTASGPLIDTITILLGLTVGAS
                     TQASEFLTLDSIKIFGLGALSFVIATASGVIFVKIFNLFLKKGNKINPLIGNAGVSAVP
                     DSARISQVVGLEYDPTNYLLMHAMGPNVAGVIGSAVAAGILLGFLM"
     CDS             complement(3682..4116)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: Biotin_lipoyl"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1024:Biotin-requiring enzyme (Score: 67.3; E-value:
                     2.7e-21)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg16_4"
                     /sec_met_domain="Biotin_lipoyl (E-value: 4.8e-22, bitscore:
                     67.3, seeds: 40, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKEYKYKINGNVYKVAIGDIEDNIAHVEVNGTPYKVEMEKAPKVV
                     VKPVARPAATSAPAAPATPVVKPAAASTGKSGVKSPLPGVILDIKVNVGDTVKKGQVII
                     ILEAMKMENNINADKDGKITAINVNKGDSVLEGTDLVIIE"
     CDS             complement(4140..5072)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: OAD_gamma"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg16_5"
                     /sec_met_domain="OAD_gamma (E-value: 9.3e-18, bitscore:
                     54.3, seeds: 234, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNKTKIGIFLSLMLVLGFCSSCKEQKSNNKLLLNEVLVNNESNYQ
                     DDYGVHSAWIEIFNRSYGSADLAGCYLKFSSQPGDTASYFIPKGDVLTLIKPRQHALFW
                     ADGEPRRGTFHTNFKLDATNANWIGLYDSGKKLLDQVIVPAGTLKANQSYARVSDAADQ
                     WEVKGGSEDKYVTPSTNNKTIDSNAKMEKFEEHDSVGIGMAISAMSVVFCGLILLYISF
                     KIIGKISVNLSKRNAMKAKGITDKQEAKEKQLGQAPGEVFAAISMAMHEFQSDVHDVED
                     TILTITRVKRSYSPWSSKIYTLRETPHKK"
     CDS             complement(5104..6657)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: CT_Btheta"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg16_6"
                     /sec_met_domain="CT_Btheta (E-value: 1.1e-291, bitscore:
                     956.9, seeds: 72, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSNQLEKIKELIDRRAAARLGGGEKAIAKQHEKGKYTARERIAML
                     LDEGSFEEMDMFVEHRCTNFGMEKKHYPGDGVVTGCGTIEGRLVYIFAQDFTVSAGSLS
                     ETMSLKICKIMDQAMKMGAPCIGINDSGGARIQEGINALAGYAEIFQRNILASGVIPQI
                     SGIFGPCAGGAVYSPALTDFTLMMEGTSYMFLTGPKVVKTVTGEDVSQENLGGASVHST
                     KSGVTHFTAQTEEEGLALIRKLLSYIPQNNLEEAPYVDCTDPIDRLEDSLNDIIPDNPN
                     KPYDMYEVIGAIIDNGEFLEIQKDYSKNIIIGFARFNGQSVGIVANQPKYLAGVLDSNA
                     SRKGARFVRFCDAFNIPIVSLVDVPGFLPGTGQEYNGVILHGAKLLYAYGEATVPKVTI
                     TLRKSYGGSHIVMSCKQLRGDMNYAWPTAEIAVMGGAGAVEVLYAREAKEQENPAQFLA
                     EKEAEYTKLFANPYNAAKYGYIDDVIEPRNTRFRIIRALQQLQTKKLTNPAKKHGNIPL
                     "
     CDS             complement(6716..7228)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: Glyoxalase_4"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg16_7"
                     /sec_met_domain="Glyoxalase_4 (E-value: 3.6e-26, bitscore:
                     81.2, seeds: 51, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKNFFIKEEFSFFVLLYTFIKKDTILTLIYIVMKISHIEHLGIAV
                     KSIEEALPYYENVLGLKCYNIETVEDQKVRTAFLKVGDVKIELLEPTSPESTIAKFIEK
                     NNGNGGMHHLAFAVEDGVAGALAEVEEKGIRLIDKAPRKGAEGLNIAFLHPKSTLGVLT
                     ELCEKPE"
     CDS             7422..8909
                     /locus_tag="ctg16_8"
                     /transl_table=11
                     /translation="MKKNILLAVCFLMPLATMAQNDTLGHERNITLSEAIVLARTQSVD
                     AAVALNELKTAYWEYRTFRADLLPEVNFTGTLPNYNKSYSTYQNSDGSYSFVRNNTLGL
                     SGQLSVDQNIWFTGGKLSLTSSLDYLKQLGSGGAKQFMSVPVSLELTQPVFGVNTLKWN
                     RRIEPVRYAEAKAEFISATEEVTMKTITYFFELLLAKESLATAMQNKTNADRLYEVAIA
                     KRKMGQISENDLLQLKLNSLQGKADVTEAESNLNAKMFQLRSFLGVSEQESLNPVLPAT
                     VPDIKMEYDRVLNKALERNSFAQNIRRRQLEADYEVATARGNLRSIDLFASVGYTGQNH
                     EFSSAYRDLLDNQIVQVGVKIPILDWGKRRGKVRVAKSNREVVLSRIRQEQMDFNQDIF
                     LLVANFNNQAQQLDIAEEADVIAEKRYKTSVETFMIGKISTLDLNDAQNSKDEARQKHI
                     SELYYYWYYFYQLRSLTLWDFERDTELEADFEEVVRG"
     CDS             9053..10414
                     /locus_tag="ctg16_9"
                     /transl_table=11
                     /translation="MILIIDDDSAVRSSLSFMLKRAGYEVKTAPSPREAMDIVRAEAPA
                     LILMDMNFTLSTTGEEGLTLLKQVKVFRPDVPVILMTAWGSIQLAVQGMQAGAFDFITK
                     PWNNAALLQRIETALELTAAPKEVPEEQTTALNRSHIIGKSKGLMEVLNTVARIARTNA
                     SVLITGESGTGKELIAEAIHINSQRVKQPFVKVNLGGISQSLFESEMFGHKKGAFTDAS
                     ADRIGRFEMANKGTIFLDEIGDLDPSCQVKLLRVLQDQTFEVLGDSRPRKVDVRVVSAT
                     NADLRKMVSERTFREDLFYRINLITVKLPSLRERREDIPLLARHFADRQAEVNGLPRTD
                     FSADALNFLSRLPYLGNIRELKNLVERTILVSGKPVLDAADFDAQYLRHDEPAKAAEGT
                     SFAGMTLDEIERQTILQALEQHKGNLSQVAVSLGISRAALYRRLEKYNIQVPCA"
     CDS             10405..11718
                     /locus_tag="ctg16_10"
                     /transl_table=11
                     /translation="VRIKFFFFILVLFLLGLGGMLVYLLSGKPSLYLYVLEGLIGFILI
                     YLIVFYNKIVKPMNTIGSGMELLREQDFSSRLSRVGQYEADRIVNIFNRMMEQLKNERL
                     RMREQNHFLDLLIQASPMGVIILTMDDEVSQLNPMAVKMLGVRMEEAMAKRLDQMDSPL
                     AAELSSIPKDETAVVRLNDANIYKCTHSSFIDRGFKHPFFLIERMTEEVMRAEKRAYEK
                     VIRMIAHEVNNTTAGITSTLDTVEQALSTEDDMEDICDVMRVCTERCFSMSRFITRFAD
                     VVKIPEPTLAPVQLNELVSMCKRFMEGMCNDRNIELRLECDPEVGMVRMDASLFEQVLV
                     NIIKNAAESIEGDAGENGQQGEIIVRTTAPASVEVVDNGPGISKETEAKLFSPFFSTKP
                     NGQGIGLVFIREVLSRHGCTFSLRTYNDGLTRFRILFN"
     CDS             complement(11745..13085)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Aminotran_1_2"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) GlcNAc_2-epim"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg16_11"
                     /sec_met_domain="Aminotran_1_2 (E-value: 3.7e-23, bitscore:
                     71.7, seeds: 48, tool: rule-based-clusters)"
                     /sec_met_domain="GlcNAc_2-epim (E-value: 0.00013, bitscore:
                     10.7, seeds: 15, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="NVPGAKLLEQTYNYLLMQHAADPDSLVHEWAESIVGDQYPVPDRI
                     LHFTEILVQDYLSQEMCDNRPPRGAYDLFATEGGTAAMCYIFDSLQENFLLNKGDGIVL
                     MVPAFTPYIEIPQLSRYQFRVTKIHANRMNNEGMHLWQYSDEDIDRLKSPKIKALFVTN
                     PSNPPSYTLSPDTMARIVSIVRNDNPNLMIITDDVYGTFSPHFRSFMAEIPYNTLCVYS
                     FSKYFGATGWRNAVITLHEFNLFDKLIAKLPKEKREILHHRYSTLTLEPEKLKFIDRMV
                     ADSRQVALNHTAGLSLPQQMQMGLFAAFALLDKENKYKQKMQEIIRRRLHALWENTGFT
                     LTEDPLRVGYYTEIDMLVWAKKFYGDDFVEYLKRTYSPLNVVFRLAKETSLVLLNGGGF
                     DGPEWSVRASLANLDEKDYATIGQGIKKILEEYAKEFFKNGKAKDKN"
ORIGIN
        1 aaaaacgagc cgtcgttgat gttgtcggga tcttactggg aagtataagg gtctacgtgc
       61 ggggtcagtt tgaaggaggt ctgcacgaag ttgttttcgt ggtcggggtt gttgaaccaa
      121 tctttggagg gcatgtcctt aatccataca tgctctacgc cgcagtggtt gaaaatcatg
      181 tccattacga ttttgatgcc gcgtgcatgg gctttttcaa tcagttgctt gtattcttcg
      241 ttggtaccga agcgcgggtc taccttgtag tagtctgtgg tggcatagcc gtgataggaa
      301 ccgccggtca tgttgttttc cagtaccgga gtaaaccaga gggctgtgac gccgaggttg
      361 gagaagtagt ccaggtgttg ttcgatgccg gcaaggtcac cgccgtggcg tgcattgggg
      421 tcattgcggt ctatcttgta ctcggccatg cccgcaatct ggtcattgtc cgggttgcca
      481 ttggcaaagc ggtcgggcat cagcaggtac agtgcgtcgg aggcgtcgaa acctttatgt
      541 tcgcaacctt tcttgttgcg tgccttcagt tcatattcct ttacgagttt cttttttcct
      601 tcagtgaagg tgaggttgaa tttgccgggt tttacatcct tgtccagttt cagatagacc
      661 aggaggtagt tgttgctttc cagcttgacg gtgctgctca atgagacgcc gggataattg
      721 acggatactg ccgcgttgcc gatgccttcg ccatagacca tcagctggag ttccgggttc
      781 tgcatgccgg tgtaccaaaa cggagggtcg attttgttca cattcatagc tgcatacgta
      841 ctgagggaga gtaagagtgt tcccaagatt aagaatactt ttttcatgat agtaacttta
      901 cggttaattt ttgcgctaat ttaaaacaaa taacggagaa agttaatctt tctccgttac
      961 tgtaccttat tatattatgc aaacgttttc attggggcta tttgatgggg gttacgctgg
     1021 cggtatcgac ctttcccttg aagaagtcct ctttcttgcg cttttctctg atgtccttca
     1081 gccagttttc ggcggcattg tatcggttgt cttctccgat gatgggaact ccgtccgcat
     1141 ctacttcctg cactttgtcc ttgctgtttt tcggacgggt tttcaggtag gccgttaggt
     1201 atctctctgc tttggacgca tctttcagat agtaataata gataaaggct gcgtcgtaga
     1261 gcagtttgtg tttctgccgg tcgtattttt cgtattgcgt cagaagggta ttcgcctggt
     1321 cggtgtattg aaatgccatc ttgtagcagt ccgcaagccc cacatatagg cgggacatga
     1381 cactgtcgct gggcatggcg aggcttacgg cagtttccag ataagtcact ccatcctctt
     1441 tccatgatgt cttggagcag gcgcgtccca gataatagag aacgttgatg ttggtattgt
     1501 catctttaag agccctttcc agcaggtcgt gtgctgggta gaagtcttcg agggcataat
     1561 agctgattcc ggcgtagaag caggtttgga aagaactgtc tttttcctgt aacagttgtt
     1621 catatctttc tattgctttg gggtaatctt tgttcaggca ataggcttgg gcattgatgc
     1681 ggttcacaag gacgttggtg gagtctatgg aacggtattt ctccgttatg tttatggcgt
     1741 cttcatactg gtggcctgct acatagatgt tgccgagttt ggcagcagac aggtaatcat
     1801 tgggatatct tttctgtatg tccaggtagg catctatcac atgcatgatt tctgtgttgt
     1861 catagacttg ccccatactt tcggctctaa ggtgtagtac ataggcggaa ctgtcccttt
     1921 ctgccagcag gttgctttcc tttagagact cacggtatct cttcatgttc atcagcagac
     1981 tgatatactg gatgcgtgcg tatttattgt ccggatttat gtggagcgca ttttggtagt
     2041 aatccagtgc ctcgctatat ttggcaagtg atttgcagca ttcggcagct tcaatgtatg
     2101 cccggggatt gagagaatcc tgagctacga cttcctgaaa tacgctcaga gcttcaaggt
     2161 tattgcccag ccctttcagc gctttccctt tttggtagag tagggggacg gtcggggttt
     2221 cttgatcgat cagcatcaag gctgtttcat aatcgtagtt ggccatcgcc tcttgaatgg
     2281 gatttgtggt ctgtgccgcc agaagcgaac agcatgcact gaaacataag gagataaaaa
     2341 gctttcgcat acagtatatc atttatatga ggttaaactg actgcaagtt actaaaaaga
     2401 atgtatttac gaaataatcg taatctgttt tagatagatt aacgaaaaag cccctccaaa
     2461 aatgaagggg ctctaaaata gttcagaatt caagccggat aacggaatga ataaatgtat
     2521 tacattaaga atcccagcag gatacctgct gctacagcgg aaccgattac accggcaacg
     2581 ttcgggccca tggcatgcat cagcagatag ttggtaggat cgtattccag acctactact
     2641 tgggagatac gtgcagagtc gggtacggca gatacaccgg cattaccgat caacggatta
     2701 atcttgttgc ctttcttcag gaagaggttg aaaatcttca cgaagatgac accggatgct
     2761 gtggcaatga caaatgataa ggcgcccaga ccgaatatct tgattgaatc aagggttaag
     2821 aactcggatg cttgcgtaga agcacctact gtcaaaccaa gcagaatagt aatggtatca
     2881 atcagcggac cactggctgt gtttgccaga cgacgtgtaa ctccactttc tttcagtaaa
     2941 ttaccgaaga acagcatacc cagcaaaggc agaccggatg gtacaaggaa tgtggttagt
     3001 aacaaaccga taatcgggaa cattactttt tccgtatgtg aaaccacacg gggaggtttc
     3061 atacggataa gacgttcatt tttactggtc agccaacgca taataggcgg ctgtatcacc
     3121 ggtactaatg ccatatatga ataggctgat accgcaatgg cacccattaa gttaggagcc
     3181 agtttggaag agaggaagat ggcagtcgga ccatcggcac caccaatgat accgattgca
     3241 ccagcctgca tcgggtcaaa tcctatggca agggcaatca tataagcacc gaatataccg
     3301 aattgggctg ctgcaccaac caacattaat ttggggttcg atatcaaagc agagaaatcc
     3361 gtcatggcac cgatacccag gaatatgagt ggcgggtacc aaccggaggt tactccctgg
     3421 tacagaatat taagtacgga accttcttca tagataccga cttttaatcc ggcttccata
     3481 ttgaaaggta tattaccaat cagcataccg aaaccgatag gaattaatag catcggctca
     3541 aattccttgg ctacagccaa gtatatgaaa aacaaaccta ccagaagcat taccacatgt
     3601 cctaccgttg cattggcaaa acctgtataa gtccagaagt cggcaaggtt gtttcctaaa
     3661 aatgtgataa attctcccat attattcaat aattacgagg tcagtacctt cgagaacaga
     3721 gtcccctttg tttacattga tggctgtaat cttaccgtct ttatcagcat tgatattgtt
     3781 ttccatcttc atggcttcca aaatgatgat aacttgtccc ttctttactg tatcgccgac
     3841 atttactttg atatcgagga ttacaccggg aagcggagat tttacacctg acttgccggt
     3901 agaagcagcg gccggtttta ctaccggagt agcaggagca gcaggagcgg atgtggctgc
     3961 cggacgtgct accggtttaa caactacctt cggtgctttt tccatttcaa ctttgtaggg
     4021 agtaccgttc acttctacat gagcgatgtt gtcttcaata tctccaatgg caactttata
     4081 tacgttaccg ttaattttat atttatattc tttcatcgtt ttattttatt atgggtgact
     4141 tactttttgt gaggagtctc acgcaacgta taaatctttg aactccacgg tgagtaactg
     4201 cgttttacac gggtaatggt aagtatcgtg tcttccacat cgtgtacatc gctttggaat
     4261 tcgtgcatgg ccattgaaat ggcagcaaaa acttctcccg gagcctgccc cagttgtttc
     4321 tcttttgctt cttgtttatc agtaatacct ttagctttca tggcattgcg tttgctgagg
     4381 ttaactgata ttttacctat aatcttgaag gagatgtaga gtaatatcag cccgcagaat
     4441 acaacgctca tggcagaaat agccataccg atacctacgc tgtcatgctc ttcgaatttt
     4501 tccattttgg cattgctgtc gatagtcttg ttgttggtac tcggagtgac atatttatct
     4561 tcgcttccac cctttacttc ccattggtcg gctgcatcac tgacacgggc ataggattgg
     4621 ttggctttta aagtaccggc aggcactatg acttgatcaa gcaatttctt gccggaatca
     4681 tacaacccaa tccagttggc atttgtggca tccagtttga agttcgtatg aaatgtaccg
     4741 cgtcttggtt ctccatcagc ccagaaaagt gcatgctgac gtggttttat gagtgtcaga
     4801 acgtcacctt tgggaatgaa ataactggca gtatcacccg gctggctgct gaatttcaga
     4861 tagcaacctg caaggtcggc gctgccgtat gatctgttga atatttcaat ccatgcgctg
     4921 tgcacaccgt agtcatcctg atagttgctt tcgttgttga ccagcacttc attcagcagc
     4981 agtttgttgt tcgatttctg ttctttgcaa gaagagcaaa agcctaacac cagcatcaat
     5041 gaaaggaata ttccgatttt tgttttattc ataatcgttc ttgttttagt gtgaaaagct
     5101 tgattacaag ggaatattac catgcttctt agccgggtta gtcaatttct tggtttgcaa
     5161 ctgttgcagg gcacgaatga tgcggaaacg tgtgttacgc ggttcgataa catcatcaat
     5221 gtagccatat ttagctgcat tataaggatt ggcaaacaac ttggtgtatt cagcctcttt
     5281 ttcagccagg aattgagccg gattttcctg ctctttggct tcgcgggcat ataatacttc
     5341 tacagcacct gcaccaccca ttacagcgat ttcagcagta ggccaagcat aattcatgtc
     5401 gccacgcagc tgcttacagc tcatcacgat gtgcgaacca ccgtaggatt tacgcagtgt
     5461 gatggtaacc ttgggtacag tagcttcacc gtatgcatac agcagtttgg caccgtgcag
     5521 gatgacgccg ttgtactcct ggccggttcc cggaaggaat cccggtacgt ctaccaatga
     5581 tacgatagga atattgaagg cgtcgcagaa acggacgaag cgtgcgccct tgcgggatgc
     5641 gttgctgtcg agcacacctg ccagatactt cggctggttg gcaacaatac ctacggactg
     5701 tccgttgaaa cgtgcgaaac caataatgat attctttgaa taatcttttt ggatttcgag
     5761 gaactcacca ttatctatga tagcaccaat tacctcgtac atatcgtacg gcttgttcgg
     5821 gttatcagga atgatgtcgt tcagggaatc ttccagacgg tcgatagggt ctgtacagtc
     5881 tacataggga gcttcttcca ggttgttctg gggaatgtag ctcaacagtt tgcggataag
     5941 agccaaacct tcttcttctg tctgtgcagt aaaatgagta acaccagatt tggtggagtg
     6001 aacgctcgcg ccacccaggt tttcctggct tacgtcttct ccggttacag tctttactac
     6061 cttcggaccg gtaaggaaca tgtaggatgt accttccatc atcaaagtaa agtctgtcaa
     6121 ggcaggagag taaacggcgc caccggcaca aggaccgaaa ataccggaaa tctgcggaat
     6181 gacacccgaa gcaagtatgt tacgttggaa gatttcagcg tagccagcca aggcattaat
     6241 accttcctga atacgtgcac cgcccgagtc gttgataccg atacacggag cacccatttt
     6301 catggcttgg tccataatct tacagatttt cagagacatg gtttcggaca gtgaaccggc
     6361 agaaactgtg aagtcctgtg cgaagatata aaccagacgg ccttcgattg taccgcaacc
     6421 ggttactaca ccgtcaccgg ggtagtgttt cttttccatg ccgaagttgg tgcatctatg
     6481 ttctacgaac atgtccattt cttcgaaact gccttcgtcg agaagcatgg ctatgcgctc
     6541 gcgagctgta tatttaccct tctcgtgttg ctttgcaatc gctttttcac caccaccgag
     6601 acgtgctgca gcgcggcggt ctataagctc tttaatcttt tcaagttgat tactcatgaa
     6661 tttatattct ttaagtgttt atacaattta tgatttgatg attttacagt cttgcttatt
     6721 ccggtttctc gcaaagctcg gtcaggacac cgagagttga cttcggatgc aggaatgcaa
     6781 tgttcagacc ttctgcacct ttgcggggag ctttgtctat aaggcggata cctttttctt
     6841 cgacttcggc aagcgcaccg gccactccgt cttcaacggc aaatgccaga tgatgcatgc
     6901 caccgttacc gttgttcttt tcgatgaact tggcaattgt gctttcggga gaagtaggtt
     6961 ccaacaattc gatctttaca tcgcccactt tcaggaaagc ggttctaact ttctgatctt
     7021 ccacggtttc gatgttgtag catttcaaac ctaaaacgtt ttcgtagtac ggaagggctt
     7081 cttcaatgct cttaacggca atgcccagat gctcaatgtg tgaaatcttc ataactatat
     7141 aaattaatgt tagtattgta tcctttttaa taaaggtata aagcagcaca aagaaagaga
     7201 attcttcctt aataaagaaa tttttcatca attaattaat ggttaattga actttagaag
     7261 gattttttca gactttagat agagaccggt tgttttcttg atatcgtccg ctaacggaca
     7321 tccccactgt ccgaaaatga acacttaccc ctctatgaaa cctttccggc cacttggcac
     7381 actctttgct tttctgtttg cgacaatttt aaagattgaa catgaaaaag aatattttac
     7441 ttgcagtttg ttttttgatg ccgttggcaa ccatggcgca gaatgatact ttgggacatg
     7501 aacgcaatat tacgctgtcg gaggccattg tactggcccg tacgcagtct gtggatgctg
     7561 ctgtggcatt gaatgaattg aaaaccgcgt attgggaata ccgtacattc cgtgcggact
     7621 tgttgccgga agtgaatttc accggtacac tacccaacta taacaagtcc tacagtacct
     7681 accagaattc cgacggctcc tatagctttg ttcgcaacaa tacactgggg ctgtccggac
     7741 agctttcggt agaccagaac atttggttta cggggggtaa gctgtcactg acttcttcgc
     7801 tggattatct caaacaactg ggttccggag gagcgaagca gttcatgtca gtccccgtga
     7861 gtctggagtt gacgcaaccg gtcttcggag tgaatacctt gaagtggaac cgccgtatag
     7921 agcccgtacg ctatgccgag gcaaaggccg agttcatttc agctacggaa gaggtgacga
     7981 tgaaaaccat cacttatttc tttgagttgc tgctggccaa agaatcgctc gctaccgcca
     8041 tgcagaacaa gacgaatgcc gaccgccttt atgaagtggc catagccaaa cgtaaaatgg
     8101 gacagatatc cgagaatgat ttgttgcagc ttaaactgaa ttcattgcag ggcaaggccg
     8161 acgtgactga ggcagagagc aacctgaatg caaaaatgtt ccagctccgt tctttcctcg
     8221 gggtgtccga gcaggaaagc ctgaatccgg tgttgcccgc cactgttccc gatataaaga
     8281 tggagtatga ccgtgtgctg aacaaggcac tggaacgcaa ctcctttgca cagaacattc
     8341 gccgccgcca gctcgaagct gattatgaag tggcaacggc acgcggaaac ttgcgcagca
     8401 tcgacctctt tgccagtgtg ggctatacgg ggcagaacca tgaattctct tcagcctacc
     8461 gggacttgct tgataatcag attgtgcagg taggcgtcaa gattcctatc cttgactggg
     8521 gcaagcgccg cggcaaggta agggtggcaa agagcaaccg tgaagtggtc ttgtccagaa
     8581 tccgtcagga acagatggac tttaaccagg acatcttttt gctggtggct aacttcaaca
     8641 accaggcgca acagctggac atagccgaag aggcggatgt cattgctgag aagcgttaca
     8701 agaccagtgt agagaccttt atgataggta aaatcagcac cctggacctg aacgatgcac
     8761 agaactctaa agacgaagcc cgtcaaaagc atatttcaga gctgtactac tattggtatt
     8821 acttctatca gctccgcagc ttgacccttt gggattttga acgcgatacg gaattggaag
     8881 ctgattttga agaggtggta agaggataag tcgacgggtt gcaagtgata agttatgaat
     8941 tatttgccgg taaaagtacc gtatatgcga tattataggt gaataactta taacttatca
     9001 ttcataactc tgctttttta cttatttttg cgggaaacaa actacaattt ttatgatact
     9061 gataatagac gacgatagtg ctgtgcgctc ttccctcagc tttatgctga agcgtgccgg
     9121 atatgaggtg aaaacggctc caagtcctcg cgaagctatg gacatagtta gggccgaagc
     9181 tcccgccttg attttgatgg atatgaactt cactctttcc actaccggag aagagggact
     9241 taccttattg aagcaggtaa aggtgttccg tcccgatgtg cccgttattt tgatgacggc
     9301 atggggaagt atccagcttg ccgtgcaggg tatgcaggcc ggcgcattcg atttcataac
     9361 caagccttgg aacaatgctg ctcttttgca gcgcatcgag acggcccttg agcttacggc
     9421 cgccccgaaa gaggtgccgg aagagcagac taccgcattg aatcgcagcc atattatagg
     9481 taagtccaaa gggctgatgg aagtgctgaa cacagtggct cgcatagccc gtaccaatgc
     9541 ttcggtgctg attacgggcg aaagcggaac gggcaaggag ctgattgccg aagccatcca
     9601 tatcaacagc caacgtgtga agcagccttt tgtcaaggtg aatctcggcg gcatctcgca
     9661 gagcttgttc gagagcgaga tgttcggcca taagaaaggg gcgtttaccg atgccagcgc
     9721 cgaccgtata gggcgttttg aaatggcaaa taaaggtact atcttcctcg acgagattgg
     9781 tgacctcgac ccttcctgcc aggtgaaact gctgcgcgtg cttcaagacc agacattcga
     9841 agtgctgggc gatagccgtc cccgcaaagt cgatgtgcgc gttgtgtccg ccactaatgc
     9901 agacctccgc aagatggtgt ccgaacgtac tttccgtgaa gacctttttt accgtatcaa
     9961 cctgattacc gtaaaactgc cctccttgcg ggagcgccgt gaagatattc ctttgctggc
    10021 acgtcacttt gccgaccgtc aggcagaggt gaacggcttg ccgcgtacgg atttctcggc
    10081 cgacgctctg aatttccttt cccgcctgcc ttatctgggc aacattcgtg agttgaagaa
    10141 tctggtggag cgtaccattc tggtcagcgg caagccggtg ctggatgccg cggatttcga
    10201 tgcccaatat ctgcgtcacg acgaaccggc caaagctgcc gaaggtactt cttttgcagg
    10261 tatgaccttg gatgaaatag agcggcagac tatcttgcag gcgttggaac agcataaagg
    10321 gaatctcagt caggtggcag tgtcattagg catcagccgc gctgcgcttt acagacgttt
    10381 ggaaaaatat aatattcaag tcccgtgcgc ataaaattct ttttcttcat acttgtcctt
    10441 tttctgctcg gtctgggtgg aatgctggta tatctgctga gtggaaagcc ttctttgtat
    10501 ctgtacgtgt tggaggggct catcgggttt atccttatct atctgatagt attctataat
    10561 aagatagtga agccgatgaa caccataggc agcggtatgg agttgctgcg cgagcaggat
    10621 ttcagtagtc gtctcagccg ggtagggcag tacgaagcag accgcattgt gaatatcttt
    10681 aaccgaatga tggagcagct caagaatgaa cggttgcgca tgcgcgagca gaatcacttc
    10741 ttggatttgc tgattcaggc atctccaatg ggggttatta tcctgacaat ggacgatgaa
    10801 gtgtcgcaac tgaatccgat ggcggtaaag atgctcggtg tccgtatgga ggaggcgatg
    10861 gcaaagcggc tggaccagat ggactccccg ttggctgccg aactttcgtc cattcccaaa
    10921 gacgagacgg cagtggtccg tctcaatgac gcgaatattt ataaatgcac ccattcttct
    10981 tttattgaca gagggttcaa acatcctttt ttcttgatag agcgtatgac ggaagaagtg
    11041 atgcgtgccg agaaacgtgc ctatgaaaag gtaatccgca tgatagctca tgaagtgaac
    11101 aataccactg cgggcatcac ttccacactc gatacagtgg agcaggcact ttctacagaa
    11161 gatgatatgg aggacatctg cgacgtgatg cgcgtttgta cggagcgttg tttctcgatg
    11221 agccgtttca ttacccgttt tgcagatgtg gtaaagatac ccgaacctac cctggcaccc
    11281 gtccagctga atgagttggt gtccatgtgc aagcgtttca tggaaggaat gtgcaatgac
    11341 cgcaatatag agctacgtct ggaatgcgac ccggaggtgg gaatggtgcg tatggatgct
    11401 tctctttttg agcaggtgct tgtgaatatc atcaagaatg ccgccgaaag tatagagggg
    11461 gacgccggag aaaacggaca gcaaggtgag ataatagtaa ggaccactgc ccccgcttct
    11521 gtcgaagtcg ttgacaatgg tccggggata agtaaagaga ccgaagctaa actcttcagc
    11581 cccttctttt ccaccaagcc gaacgggcag ggaattggcc tggtgtttat ccgggaagtt
    11641 ttgagccgtc atggttgcac gttctcccta cgtacctaca acgatggatt gacccgcttc
    11701 cgtatactat ttaattgaaa tttgaaagtt ttacctttca cctttcaatt tttatctttc
    11761 gcctttccat ttttaaagaa ttcttttgca tactcctcca gtatcttttt gatgccttgg
    11821 ccgatggttg catagtcttt ctcgtccaga ttggcgagtg aggcgcgcac gctccattcg
    11881 gggccgtcaa aaccaccgcc gttcagcagc accagagagg tttctttggc aaggcggaag
    11941 actacgttca gcgggctgta ggtgcgtttc agatattcta caaagtcgtc cccatagaac
    12001 ttctttgccc aaaccagcat gtcgatttct gtataataac ctacgcgcaa cgggtcttcc
    12061 gtcagcgtga aaccggtatt ctcccaaagg gcatgcaatc ggcggcggat aatctcctgc
    12121 atcttttgct tgtatttgtt ttccttgtcc agcagggcaa aggcggcgaa aaggcccatc
    12181 tgcatctgtt gtggcaatga cagtccggcg gtatggttca gcgccacctg acggctgtcg
    12241 gcaaccatac ggtcgataaa cttcagtttt tcaggttcca gagtgagggt ggagtagcgg
    12301 tggtgcagaa tctcccgttt ctctttcggc agtttggcta tcagcttgtc gaacaggttg
    12361 aattcgtgca gggtaatgac cgcattgcgc catccggtgg caccgaagta tttggagaat
    12421 gaatagacgc aaagcgtatt gtagggaatt tctgccatga acgaacggaa atgtggactg
    12481 aatgtaccgt atacgtcgtc tgtaataatc atcagattag ggttgtcatt cctgacgatg
    12541 ctcacgatgc gcgccattgt atccggactg agtgtgtagc tgggcggatt actgggattg
    12601 gtgacaaaga gggccttgat tttagggctt ttcaagcggt ctatgtcttc gtcgctgtac
    12661 tgccagaggt gcatcccttc gttattcatg cggttggcat gtattttggt cactcgaaac
    12721 tggtagcggc tgagttgtgg gatttcaata tagggggtaa aggcaggaac catgaggacg
    12781 atgccgtccc ctttgttcag caggaagttt tcctgcaggg agtcgaagat gtagcacatg
    12841 gcggctgttc caccttcggt ggcaaacagg tcataggcac cccggggagg acggttgtcg
    12901 cacatctctt gcgaaaggta atcttgcaca aggatttccg taaaatgaag gatgcggtcg
    12961 ggcacgggat actggtcgcc tacaatgctt tcggcccatt cgtgtacaag gctgtcgggg
    13021 tcggcggcat gctgcatcag caggtagttg taggtttgtt ccagcaattt ggcgcccggt
    13081 acgttat
//
