LOCUS       gnlProkkaOOPKPEOC_810   9919 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|OOPKPEOC_810.
ACCESSION   gnlProkkaOOPKPEOC_810
VERSION     gnlProkkaOOPKPEOC_810
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2024-11-30 23:15:19
            Original ID  :: gnl|Prokka|OOPKPEOC_810
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 9919
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..9919
                     /aStool="rule-based-clusters"
                     /category="other"
                     /contig_edge="True"
                     /core_location="[566:4919]"
                     /cutoff="20000"
                     /detection_rule="(phosphonates and minimum(1,
                     [2-Hacid_dh_C, Aldedh, Aminotran_1_2, Aminotran_5, AurF,
                     CTP_transf_like, DUF4992, Fe-ADH, HMGL-like, Metallophos_2,
                     NTP_transf_3, NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C,
                     TPP_enzyme_N, phosphonates]) and not (phosphonatesHydrolase
                     or phosphonatesMeIsocitrateLyase))"
                     /neighbourhood="5000"
                     /product="phosphonate"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      567..4919
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(phosphonates and minimum(1,
                     [2-Hacid_dh_C, Aldedh, Aminotran_1_2, Aminotran_5, AurF,
                     CTP_transf_like, DUF4992, Fe-ADH, HMGL-like, Metallophos_2,
                     NTP_transf_3, NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C,
                     TPP_enzyme_N, phosphonates]) and not (phosphonatesHydrolase
                     or phosphonatesMeIsocitrateLyase))"
                     /neighbourhood="5000"
                     /product="phosphonate"
                     /protocluster_number="1"
     cand_cluster    1..9919
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(phosphonates and minimum(1,
                     [2-Hacid_dh_C, Aldedh, Aminotran_1_2, Aminotran_5, AurF,
                     CTP_transf_like, DUF4992, Fe-ADH, HMGL-like, Metallophos_2,
                     NTP_transf_3, NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C,
                     TPP_enzyme_N, phosphonates]) and not (phosphonatesHydrolase
                     or phosphonatesMeIsocitrateLyase))"
                     /kind="single"
                     /product="phosphonate"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..9919
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="phosphonate"
                     /region_number="1"
                     /rules="(phosphonates and minimum(1, [2-Hacid_dh_C, Aldedh,
                     Aminotran_1_2, Aminotran_5, AurF, CTP_transf_like, DUF4992,
                     Fe-ADH, HMGL-like, Metallophos_2, NTP_transf_3,
                     NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C, TPP_enzyme_N,
                     phosphonates]) and not (phosphonatesHydrolase or
                     phosphonatesMeIsocitrateLyase))"
                     /tool="antismash"
     CDS             469..570
                     /locus_tag="ctg810_1"
                     /transl_table=11
                     /translation="MINFTVGPVQSSDAVRVIGAEQVPYLEQQSFQK"
     CDS             567..1319
                     /NRPS_PKS="Domain: Aminotran_5 (3-189). E-value: 1.1e-20.
                     Score: 65.7. Matches aSDomain:
                     nrpspksdomains_ctg810_2_Aminotran_5.1"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: Aminotran_5"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg810_2"
                     /sec_met_domain="Aminotran_5 (E-value: 2.3e-18, bitscore:
                     57.0, seeds: 34, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MMLENERLVKKFANATKDSKVVFMTCSGSGGMEAAIINCLTPQDK
                     ALVINGGSFGERFVELLTLHKIPFTEIKLKYGRALKPEHLAEYESKGYTTFLMQKHETF
                     TGVHYDINLVSDFCKRNNCFLIVDIISTFLCDSFDMVAMDVGVMITGSQKALACAPGIA
                     VMLLAPSAIKRIEKVQCCCQYLDLKLALKNMERGQTPCTPAVGILRQINVRLKEIESAG
                     GAEVEIARCAELAKYFRDKLVKNNLPLF"
     aSDomain        576..1133
                     /aSDomain="Aminotran_5"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg810_2_Aminotran_5.1"
                     /evalue="1.10E-20"
                     /label="ctg810_2_Aminotran_5.1"
                     /locus_tag="ctg810_2"
                     /protein_end="189"
                     /protein_start="3"
                     /score="65.7"
                     /tool="antismash"
                     /translation="ENERLVKKFANATKDSKVVFMTCSGSGGMEAAIINCLTPQDKALV
                     INGGSFGERFVELLTLHKIPFTEIKLKYGRALKPEHLAEYESKGYTTFLMQKHETFTGV
                     HYDINLVSDFCKRNNCFLIVDIISTFLCDSFDMVAMDVGVMITGSQKALACAPGIAVML
                     LAPSAIKRIEKVQCCCQYLDLKL"
     CDS             1316..1690
                     /locus_tag="ctg810_3"
                     /transl_table=11
                     /translation="MTYRQVGTNSFTVKYYVEKFILDMNTMKIIRVDEYRDKKKINRPA
                     GSLFSVDGEIYRVAQKCSRAYGESIFVYKTSKNFDFIKDKKVAELTGQSIVLSDGRKPI
                     LLHTYSQAGGIEVIDYRCSL"
     CDS             1715..3025
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: PEP_mutase"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: phosphonates"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: CTP_transf_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1231:carboxyvinyl-carboxyphosphonate (Score: 190.9;
                     E-value: 4.6e-58)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg810_4"
                     /sec_met_domain="CTP_transf_like (E-value: 2.7e-12,
                     bitscore: 37.9, seeds: 65, tool: rule-based-clusters)"
                     /sec_met_domain="phosphonates (E-value: 3.1e-114, bitscore:
                     371.6, seeds: 8, tool: rule-based-clusters)"
                     /sec_met_domain="PEP_mutase (E-value: 1.9e-61, bitscore:
                     198.3, seeds: 69, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAKTVYLGMIGDIMHPGYINIINKATEYGDVIIGLFTDKAIANHR
                     RLPYLTWEQRKNVVESIRNVSRVVPQDDWSYVSNLLKYKPDYIIHGDDWQVGPDKYIRD
                     EVFKVMEKLGGEVIEIPYTQNISASGIKQEIDALGVTPQMRLSSLRRLIAAKPIVRILE
                     SHNGLTGLIAEHTKVEVNGQEREFDGMWASSLTDSTSKGKPDIEAVDLTTRLHDLNDTL
                     EVTTKPVIFDGDTGGKIEHFGFTVRTLERLGISCVIIEDKVGLKQNSLFGTDAVQTQDT
                     IEGFQAKIRAGKEAQITRDFMIVSRCESLIAGKTVDDALERCHAYVEAGTDGIMIHSKE
                     KSGEDIKEFCLRFREKNAHTPIIVVPTTYNQFTEEELAEWGINVVIYANHMLRSAYPAM
                     VKCAETILYTSRSLEASEQYCMPIKQILNLIPGTKKK"
     CDS             3060..4187
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: TPP_enzyme_N"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: TPP_enzyme_C"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1055:pyruvate oxidase/decarboxylase (Score: 74.7;
                     E-value: 1.1e-22)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg810_5"
                     /sec_met_domain="TPP_enzyme_N (E-value: 2.1e-20, bitscore:
                     63.8, seeds: 75, tool: rule-based-clusters)"
                     /sec_met_domain="TPP_enzyme_C (E-value: 8.5e-24, bitscore:
                     74.9, seeds: 323, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MVRPEFFVNILKEQGIDFYAGVPDSLLKNICAYITDHLPAEQNII
                     AANEGGAMGIAVGYHLATGKVPVVYMQNSGEGNIINPFASLTDKDVYNIPVLLVIGWRG
                     RPGVHDEPQHVKQGKVTIGLLNTMGINYAILPKDEEGAAKQIKIAVDFMKATNECYALV
                     IEKDTFDTYKLQSVEVNELAMSREETIQKVASNIEDNACIVSTTGMISRELFEARTAWS
                     QGHERDFLTVGAMGHASQIALGIALQKPERRVYCFDGDGASIMHMGNMAITASMKCKNY
                     VHIVFNNGAHDSVGGQPTVGLKIDFCAIAQAVGYKAAYSVETMEALEAKLAEFKNAEGP
                     VFLQICVKKGNRKDLGRPTTTPIQNKEAFMEFLNK"
     CDS             4191..4919
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: Metallophos_2"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg810_6"
                     /sec_met_domain="Metallophos_2 (E-value: 1e-27, bitscore:
                     88.0, seeds: 57, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKVILFADIHANLSAFEAVLADIEKHYQPDAMISLGDFIDYGMRS
                     NEIIERIQTVNIPLLANLKGNHEKALIDGELSCFSSERARVMSKYTRNHLTQTSIDYIS
                     NVMQEPMQELEIGGKKVLLLHGTIDDPYWGKLTPAKVEDEKYQDFDYVLSGHIHQPFKI
                     DVFFKVDNPIMRNQKRTTFINPGSVGQPRNQNPYAQYVYINFKTGETHFNAVPYDIEAE
                     QSLFPKEIDTFYSERLKFGI"
     CDS             4920..5915
                     /NRPS_PKS="Domain: NAD_binding_4 (83-198). E-value:
                     6.4e-10. Score: 30.4. Matches aSDomain:
                     nrpspksdomains_ctg810_7_NAD_binding_4.1"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Polysacc_synt_2"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) RmlD_sub_bind"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1010:NAD-dependent epimerase/dehydratase (Score:
                     143.1; E-value: 2.2e-43)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg810_7"
                     /sec_met_domain="Polysacc_synt_2 (E-value: 2.2e-09,
                     bitscore: 27.6, seeds: 77, tool: rule-based-clusters)"
                     /sec_met_domain="RmlD_sub_bind (E-value: 7.5e-09, bitscore:
                     25.8, seeds: 37, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKNLYVISGVTGMTGSELSRQFVSQGHTVIGFDNFFASSIDTVKD
                     IIDNPSFIFYNYDINKVAQMDEVCDKAKELKIECDGRLVFINCAAVVHTKHFYEVESTF
                     QTNVLAMKDFLERAISMRADTYINCSTSEVYSMQSWNENGGVKESDYLAMSTAEHSQRT
                     SYACGKLMTEFFMKDAVGKGRIKGCSIRFANVYSRHERFAEHIIPHIIDNLLESHTVTL
                     LENSKVNKRTFLHNIDSCRAVMELIASEDALDGTVYNVATEEEIAIIDLVKTIAIKMGI
                     NDVDIRFEGYRKSDPERRLLNTDKIRTRTSWKPIITLDEGLTMCVNSIKK"
     aSDomain        5169..5513
                     /aSDomain="NAD_binding_4"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg810_7_NAD_binding_4.1"
                     /evalue="6.40E-10"
                     /label="ctg810_7_NAD_binding_4.1"
                     /locus_tag="ctg810_7"
                     /protein_end="198"
                     /protein_start="83"
                     /score="30.4"
                     /tool="antismash"
                     /translation="VFINCAAVVHTKHFYEVESTFQTNVLAMKDFLERAISMRADTYIN
                     CSTSEVYSMQSWNENGGVKESDYLAMSTAEHSQRTSYACGKLMTEFFMKDAVGKGRIKG
                     CSIRFANVYSR"
     CDS             5912..6652
                     /locus_tag="ctg810_8"
                     /transl_table=11
                     /translation="MKYLIITVAGTATRFNRDTKEETLKCLYYTDEPQYALLAQLLKNC
                     GEYDKYILVGGYLYEKLGRFVKNELSGYGKKIELVYNEHFKDYGSGYSLYKGIEAIKEA
                     GDVTFVEGDLFFMATDFRQVYNSPKSVITINREPIYSNKAVALYINVDGKPRYLYDTNH
                     QTLTVSEPFKAIFNSGQMWKFSSSERLLKTVDSLTKEQLQGTNLEIIQAYFSDMNSEEY
                     DVVTFTDWFNCNTVADYDIVRKLM"
     CDS             6655..7134
                     /locus_tag="ctg810_9"
                     /transl_table=11
                     /translation="MNMAVLERDYRIDGIKWLLIVLVTFGHVIEPALSNPIANKLYSII
                     YIFHMPLFVFISGYYANVKDKEKLISKGFMLLETFLVVMIPQCFYYGSIIPLLNPENSG
                     WYLISLITWYIIFLLIINKLVGKIVVQYNGCGGAVIDIQLLVGRICIHASVETIW"
     CDS             7109..7669
                     /locus_tag="ctg810_10"
                     /transl_table=11
                     /translation="MLPLKQFGNLLSFQRSCMFLPFFMMGFLRRVKGLPIIPDVSKCIK
                     LVLAIASLVCFAFCLIYSGRILHVLEFNNANVWHMSNLYNQNIGMLLVLKVLVYIGSII
                     TTFAVLMFVNLPKSICAYGSKTLAYYVIQGMFAHILSTYLQVNFYQALFLCVCILILTT
                     VLLRFVDSKFITNPFSTLLKWKY"
     CDS             7657..8844
                     /locus_tag="ctg810_11"
                     /transl_table=11
                     /translation="MEILNRKLSLLKGKVENSQPITIMIIGLGSVGCYLLDYLVSLGDS
                     QLRLVVVGRNAEKMQMDINIIRTASTIRHQCRSEIKVVDNCDLNDVNSIAAVLEAEKPD
                     FIVNSSRVYSGLKYGSISWSNLRAYGIWTPLSIRYAKNIMEAYDKANCEAISINTSYSD
                     AVIPWLKSAGKAYFDFGSGNLNHLVPRIKFYIAEKYGIKNFNDIDVTIAVSHFHDVVIS
                     KEGHAEGQDILLDIKFQGKDMDFNKEELLKSCSIAMPVDQKRNMMNASSNFDIIFSVLT
                     ALREEKQVKIHTPGVNGEIGGYPIIIDGVTATAKFDESVWTIDQMRKANRESIYCDGVE
                     NITDATLVYTDELVAKVKKSFNVDLPKSVKFVDIENVADLIINQIIKPQVLIFVQ"
     CDS             9187..9429
                     /locus_tag="ctg810_12"
                     /transl_table=11
                     /translation="MDITTKIKRSKLLYYVYYYVMSGLVNLYKLFLKPDGKLMLFVCYG
                     GRHYSDSTRVIYEAMLKDERFKDYIGLRQTDCCIY"
ORIGIN
        1 attatacgtt taaatagttg gctcaaaggt attcattctc tttcgttgaa tctttcccac
       61 atgtaagaaa gattttaaag gaacaaagta aataataaca atatataaca taatattcta
      121 tctaattact taaaatttat ctaaatgggc aaaaatttta ttcacccttc attgggcttt
      181 tttatcgagc gaacgagaaa acagagtgga gtcactattg aaactctttg caaggatttg
      241 catatttctc catccacgta catagactta aaaaaaaggg tgtaacgcct cacttagtac
      301 atacgaaact cttctgcgat actatatcga tgaactggag gaactggatg atgacgaaat
      361 caggaaattg gctggggaat gggtggaaaa atggctggag gttaggaaga agggggagtg
      421 gtgattggat tggttgatta ttactgataa ttaaaggaat ctatataaat gattaatttt
      481 acagtaggtc cggtgcaatc ttctgatgct gtacgggtca taggtgccga acaggtacca
      541 tatttagaac agcagagttt tcagaaatga tgcttgagaa tgagcgcctt gttaagaaat
      601 ttgctaatgc gactaaagat agtaaggttg ttttcatgac atgttctggc tctggtggta
      661 tggaggctgc catcataaat tgccttacgc cacaggataa ggctcttgta atcaatggtg
      721 gtagctttgg tgagcgtttt gtggaattgc ttacccttca taaaattcct tttacggaaa
      781 ttaagcttaa gtatggtaga gctttgaagc ctgaacatct tgctgaatat gagagcaagg
      841 gttacactac tttccttatg cagaagcacg aaacttttac gggggtacat tacgatatca
      901 atcttgtttc tgatttttgc aaacgtaata attgtttctt gattgttgat ataatctcta
      961 ccttcctttg cgattcattt gatatggtgg caatggatgt aggggtgatg attactggaa
     1021 gtcagaaggc tcttgcttgc gctccgggta ttgcagttat gcttcttgct ccttcggcta
     1081 ttaaacgtat agaaaaggtc caatgttgct gtcagtatct tgatttgaag cttgctctta
     1141 aaaatatgga gagagggcag actccttgta ctcctgctgt tggtatcctt cgtcaaatta
     1201 atgtccgttt aaaagaaatt gagtctgcag gtggtgcgga ggtggagatt gcgcgttgtg
     1261 cagaattggc taagtatttt cgtgataagc ttgttaagaa taatcttcca ctcttttgac
     1321 ttatcgtcag gttggaacaa atagctttac agttaagtat tatgttgaga agtttattct
     1381 tgacatgaat acgatgaaga taattagggt tgacgagtat cgcgacaaaa agaagattaa
     1441 tcgtcccgca ggttcgttat tctctgtaga tggagaaatt tatcgagtgg cacaaaaatg
     1501 cagtcgtgca tatggagagt cgatctttgt gtataagaca agtaagaatt ttgattttat
     1561 taaagataaa aaggtagcag aactcactgg tcagagtata gtcctgagtg atggtagaaa
     1621 gccgattttg ttgcacactt attctcaagc aggagggatt gaggtgattg actatagatg
     1681 ctctttataa taatttgaaa aatgttaaat aataatggca aagacagttt atcttggtat
     1741 gataggtgat atcatgcatc cgggttacat taacatcatt aacaaagcta ctgagtatgg
     1801 cgatgtgata atcggtttgt tcactgataa ggcgattgct aaccaccgta gacttcctta
     1861 tctcacttgg gagcaaagaa agaacgttgt tgagagcatc aggaacgtat caagggtggt
     1921 ccctcaggat gattggagct atgtctctaa tctccttaag tacaagcctg attacatcat
     1981 tcatggtgat gattggcagg tgggtcctga caagtatatc cgtgatgagg tattcaaagt
     2041 aatggaaaag ttgggtggtg aggttatcga gattccttac acccaaaaca tctctgcttc
     2101 tggtatcaaa caagagattg atgctcttgg tgtaactcct cagatgcgtc tttcttctct
     2161 ccgtcgcctt attgcagcta aaccgattgt acgtattctt gaaagtcaca atggtcttac
     2221 tggcctcata gcagaacata ctaaggtaga ggtgaatggt caggagcgtg aattcgatgg
     2281 catgtgggct tcctccctta ccgactctac ctctaagggt aagcctgata ttgaggctgt
     2341 cgatttgact acccgtctcc atgacctcaa tgataccctt gaagtaacca caaaacctgt
     2401 tatcttcgat ggcgatactg gtggcaagat tgaacacttc ggttttaccg ttcgcaccct
     2461 tgagcgcttg ggaatctctt gcgttataat tgaagataag gtaggtttaa aacagaattc
     2521 actttttggt actgatgctg tacagactca ggatacaatc gaaggttttc aggctaaaat
     2581 tcgtgcaggt aaggaagcgc aaattactcg tgacttcatg attgtcagcc gttgtgagtc
     2641 tctcattgct ggtaagactg tagatgatgc tttggagcgt tgtcatgctt acgtagaggc
     2701 aggtactgac ggtataatga tccactccaa agagaagtct ggagaggaca tcaaggagtt
     2761 ttgcttgcgc tttcgcgaga agaatgctca tactcctatc atcgttgtgc ctactactta
     2821 taaccagttc acagaagagg aacttgctga atggggtatt aatgtagtga tttatgctaa
     2881 tcacatgctt cgttctgctt atcctgcaat ggttaaatgt gcagaaacca tcctctatac
     2941 tagccgttcg cttgaagcat ctgagcagta ctgtatgcct atcaaacaga ttcttaatct
     3001 tattccaggc acaaagaaga agtaaacatt aatttcttac cccttaaact attttacaaa
     3061 tggtaagacc cgaatttttt gtaaatatac tcaaggaaca aggtatagac ttttatgctg
     3121 gtgttcctga ttcgttgctc aagaacattt gtgcatatat taccgaccac cttcctgctg
     3181 agcagaatat tattgctgct aacgaaggag gggccatggg tattgctgta ggttatcatt
     3241 tggcaacagg taaggtgcct gtagtttata tgcagaactc tggtgaaggc aatatcatta
     3301 atccgtttgc ctctcttacc gacaaggacg tttataacat tcctgtgctc ctcgttatcg
     3361 gttggagagg gcgccctgga gttcacgatg aacctcagca tgtgaagcaa ggtaaggtga
     3421 caatcggttt gcttaatacc atgggtatca actatgctat tctgccaaag gatgaagagg
     3481 gagctgcaaa gcagataaaa atagctgtcg acttcatgaa ggcaaccaac gagtgctatg
     3541 cccttgtgat agagaaggat actttcgata cctataagct tcagagcgtt gaggtaaacg
     3601 aactggcaat gtctcgcgaa gagacgattc agaaggtggc ttcaaacatt gaagataatg
     3661 cttgtatcgt atcaactact ggtatgattt ctcgcgagct ctttgaggca cgtactgctt
     3721 ggagccaagg tcatgaacgt gatttcctta ctgtaggggc gatgggccat gcttcccaga
     3781 tagctctcgg catagctctc caaaagcctg agcgtcgagt atattgtttt gatggtgatg
     3841 gagccagcat catgcacatg ggtaatatgg ctattacagc cagcatgaaa tgcaagaatt
     3901 atgtgcacat tgtgttcaac aatggcgcac acgattctgt tggtggtcag cctactgttg
     3961 gtctcaagat tgatttttgt gcaattgctc aagctgtagg ctacaaggct gcttatagtg
     4021 tagaaactat ggaggcactt gaagcaaaac ttgcagaatt caagaacgca gaaggtcctg
     4081 ttttccttca gatttgcgta aaaaagggaa accgcaagga ccttggccgt ccaactacaa
     4141 ctcctattca gaacaaagag gcttttatgg aatttcttaa caagtaaagt atgaaagtaa
     4201 ttctgtttgc tgatatacac gccaatcttt ctgcttttga ggcggttcta gctgatattg
     4261 agaaacacta tcagccagat gccatgatta gtctaggtga ctttatcgac tatggtatgc
     4321 gttcaaatga aattattgaa cgtatacaaa ctgttaatat tccattactt gccaatttga
     4381 agggcaatca cgagaaggct ttgattgatg gggaactctc atgtttctct tcagaaagag
     4441 ctcgtgtgat gtccaaatac acaagaaacc atctcactca gacatctatt gattatataa
     4501 gcaatgtgat gcaagagcca atgcaagagt tggaaattgg tggtaagaaa gtacttcttt
     4561 tacatggaac tattgatgat ccctattggg gaaaactgac tccagcaaaa gtggaagatg
     4621 aaaagtatca ggattttgac tacgtattga gcggtcacat tcatcaacct tttaagatag
     4681 atgtattctt caaagttgac aatccaatca tgcgcaatca gaaacgtacg acttttatca
     4741 acccaggttc agttggacaa cctcgcaatc agaatccata tgcacaatat gtgtatatca
     4801 attttaaaac gggggaaacc catttcaatg cagttcctta cgatattgaa gctgaacaat
     4861 ctcttttccc caaagagata gatacttttt acagcgaacg attaaaattt ggaatataaa
     4921 tgaagaactt atatgtaata agtggtgtta ctggcatgac gggtagtgaa ctgtctcgtc
     4981 agtttgtttc tcagggtcat acggtaatcg gtttcgacaa cttctttgca agttctattg
     5041 ataccgttaa agacattatt gacaatccct cgttcatctt ctataattac gacattaaca
     5101 aagtcgctca gatggatgaa gtatgcgata aggcgaaaga actcaaaatt gagtgcgatg
     5161 gccgtctggt gtttatcaat tgtgctgctg ttgtccatac aaagcatttc tatgaggtag
     5221 agagtacttt tcagactaac gtccttgcta tgaaggattt cttggagcgt gccatttcta
     5281 tgagggctga tacttacatt aattgttcaa cttcggaggt ttactcaatg cagtcttgga
     5341 atgagaatgg cggtgtgaaa gaatctgatt atttggcaat gtcaacagcg gaacatagcc
     5401 aacgtacaag ttatgcttgc ggcaagttga tgactgaatt ctttatgaaa gatgctgttg
     5461 gcaagggacg aattaaaggt tgttctattc gctttgctaa tgtatatagc aggcacgagc
     5521 gttttgcaga gcacattatc cctcatatca ttgataatct gcttgaaagc cataccgtaa
     5581 cccttcttga aaactcgaag gtgaacaaac gtaccttcct tcataatatt gatagctgtc
     5641 gtgccgttat ggagctcatc gcttctgagg atgctcttga tggtactgtt tataatgtgg
     5701 ctactgaaga ggaaattgcc attattgatc tagtcaagac gattgcaata aaaatgggca
     5761 tcaacgatgt ggatatccgt ttcgaaggtt accgaaagtc tgatcctgag cgtcgattgc
     5821 tcaatacgga caagattcgt acccgtacta gctggaaacc tatcatcact ctcgatgaag
     5881 gcctcacgat gtgtgtaaat agtatcaaga aatgaaatat ttgattataa ctgttgctgg
     5941 aacggctacg cgttttaatc gcgacactaa ggaagaaacc ctcaaatgct tgtattatac
     6001 cgatgaacct caatacgctc ttcttgctca attgctgaag aattgtggtg agtacgataa
     6061 atatatcctt gtggggggct acctttatga gaagttggga agatttgtaa agaacgaact
     6121 ctctggttat ggcaaaaaaa tagaacttgt ttacaacgag catttcaaag actatggctc
     6181 cggctacagt ttatacaaag gtatagaggc aataaaggag gcaggtgatg tgactttcgt
     6241 agaaggcgac ttgttcttta tggctacaga tttcaggcaa gtgtataatt cgccaaagag
     6301 tgtgattacc attaaccgag aaccaatcta ctcgaataag gcagttgcgt tatacattaa
     6361 cgttgatggc aaaccaaggt atttatatga tacgaatcat cagacattaa ctgtatcaga
     6421 gccattcaag gcaatcttca acagtggtca gatgtggaaa ttttcttcat ctgagaggct
     6481 tttgaagact gttgattcgc ttacaaaaga acaacttcaa ggtactaatc ttgaaataat
     6541 tcaggcttac tttagtgata tgaatagtga agagtatgat gtagtgactt tcactgactg
     6601 gttcaactgc aatactgttg cagattatga tattgtaaga aaattgatgt aaaaatgaat
     6661 atggctgtat tagaaagaga ttacagaata gatggaataa agtggttgct cattgtatta
     6721 gttacattcg gtcatgtaat agaacctgct ttaagcaatc ctattgccaa taagctctat
     6781 tctataatct acatttttca tatgccatta tttgtcttta tcagtggtta ttatgcaaat
     6841 gttaaggata aagaaaaact gattagtaaa ggttttatgc ttttggaaac atttttggtt
     6901 gtgatgattc ctcaatgttt ttattatgga agtatcatcc ctttactaaa tccggagaac
     6961 tcaggctggt atttaatcag cctaataact tggtatatta tttttctgtt gattatcaat
     7021 aagctagttg gcaaaattgt cgtacaatat aatgggtgcg ggggggcagt tattgatatt
     7081 cagttgcttg ttggccgtat ttgcatacat gcttccgttg aaacaatttg gtaacctgct
     7141 atcgttccaa cggtcgtgta tgtttctacc attctttatg atgggtttct tgagaagagt
     7201 aaaaggcctg cctattattc ctgatgtttc aaaatgcata aagcttgttt tggctatagc
     7261 ctctttagta tgttttgctt tttgtctcat ctatagtggt cgtatactac atgtattaga
     7321 gtttaataat gccaatgtgt ggcacatgtc aaatttgtac aatcaaaata taggaatgct
     7381 tcttgttttg aaagtattgg tttatattgg atcaattatt actacattcg ctgttttaat
     7441 gtttgtgaac ctccccaagt cgatatgtgc ttatggatca aagactttag catattatgt
     7501 aatacaaggc atgtttgcac acatattatc aacctatttg caagttaatt tttaccaggc
     7561 cttgtttctc tgtgtttgca tattaatcct tacaacagtt ctattacgat ttgttgattc
     7621 taaatttatt acaaacccgt tttctacttt attaaaatgg aaatactgaa cagaaaactt
     7681 tcccttctca aagggaaggt tgaaaatagt cagccaataa ctattatgat tattggtttg
     7741 ggtagcgttg gatgctactt gttggattat cttgtatcac taggtgattc acaacttcgt
     7801 cttgttgtgg taggacgtaa tgccgaaaag atgcagatgg atataaatat tattcgtact
     7861 gcttcaacca ttcgtcacca gtgccgtagc gagattaagg tggttgataa ctgcgacctt
     7921 aacgatgtga acagcattgc agctgtactt gaagcagaaa agcctgactt catagtaaat
     7981 agtagtcgag tttactctgg tttgaagtat ggtagcatct catggagtaa tcttcgtgca
     8041 tacggcattt ggactccgct ttctattcga tatgcaaaga atataatgga ggcatacgat
     8101 aaggccaact gtgaggcaat ctcaatcaat acttcatatt ccgatgctgt tattccttgg
     8161 ctaaagtctg cgggtaaggc ttattttgac tttggtagtg gtaatttgaa tcatcttgtg
     8221 cctcgtataa aattctatat tgcagagaaa tatggtataa agaattttaa tgacattgat
     8281 gtaactattg cggtatcaca ttttcatgat gttgtcattt ctaaggaagg tcatgcagaa
     8341 ggtcaggaca tcttgcttga tataaagttt caaggcaagg atatggattt taataaggaa
     8401 gaacttctta aatcctgttc tatagcaatg cctgtagatc agaagcgcaa tatgatgaat
     8461 gcttccagta attttgatat catattctct gttcttactg ctcttcgaga ggaaaaacaa
     8521 gtcaaaatac atactcctgg ggtaaatggt gaaattggtg gttatcctat aattattgat
     8581 ggagtaactg ctactgccaa gtttgatgag tctgtatgga ctatagacca gatgcgtaaa
     8641 gctaaccgtg agtcaattta ttgtgatgga gtagagaata taactgacgc tactctcgtc
     8701 tatactgatg aacttgtagc taaggtaaag aagtcgttta atgttgattt gcctaagtcg
     8761 gtaaagtttg tggatattga aaatgtagca gatttaatta tcaatcagat aattaaacct
     8821 caagtgctta tttttgtgca ataatttgta aactaatggc agataataga ttgttgttaa
     8881 ttttctgtat aatctttaac ttatagtttt atgatataca cagctatgta agcactttaa
     8941 aaagttcaaa atgaaatgtt agccttcgtt gtaaattaaa attagcaaga tatgtatagc
     9001 agcgaagatt tagcaagttt ttattttcag taccagacca aggctttacc tcatgtcaag
     9061 ttcctccagt ccttttgtat gaagcataaa gttcctataa tatttttcat aagtggtata
     9121 aggatacgcg taataaaata attacagttc tatatctccg attgtcaaat gaaaaatgta
     9181 ataaatatgg atatcacaac aaagataaaa agaagtaaat tactttatta cgtctactat
     9241 tacgtaatgt caggtttggt aaatttgtac aagttgttct tgaagccaga cggtaaactc
     9301 atgctttttg tatgttatgg tggacgtcat tattccgata gtacgcgagt gatttatgag
     9361 gccatgttga aggatgaacg tttcaaggac tatataggat tacgacaaac tgattgctgc
     9421 atttattgat ttaagagaaa agcgatttat ctaaggttat gaagaaagtt attaggaaca
     9481 tacgatttgt ttcatcaggg gcattataac ctcttaaaac gtgcgaaagc tttaggtgat
     9541 tacctcattg tgggtgttac cacagataat ttcgacttgg agagaggcaa gatgaacacg
     9601 tgcaataacg tgatggaacg tattgaagcg gttaaatcca ctggtcttgc agatcaattg
     9661 tgatagaaga atatcgtggg cagaagattg atgatataca gaaatatgga gtggatgttt
     9721 ttgcaatcgg ttcagattgg gaaggctatt ttgactatct caatgagttc tgtaaagtca
     9781 tttaccttcc tcgcactcag ggtgtctcat ctactttgct tcgccagaag cgtcctattg
     9841 ttaatattgg cattattggt actggcagta ttgcttcacg ttttgttcca gagccgaaaa
     9901 atgtgaatag tgcgtccgt
//
