LOCUS       gnlProkkaIGJIJGHH_11   13549 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|IGJIJGHH_11.
ACCESSION   gnlProkkaIGJIJGHH_11
VERSION     gnlProkkaIGJIJGHH_11
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2024-11-30 22:51:21
            Original ID  :: gnl|Prokka|IGJIJGHH_11
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 503237
            Orig. end    :: 516786
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..13549
                     /aStool="rule-based-clusters"
                     /category="other"
                     /contig_edge="False"
                     /core_location="[5000:8549]"
                     /cutoff="20000"
                     /detection_rule="(phosphonates and minimum(1,
                     [2-Hacid_dh_C, Aldedh, Aminotran_1_2, Aminotran_5, AurF,
                     CTP_transf_like, DUF4992, Fe-ADH, HMGL-like, Metallophos_2,
                     NTP_transf_3, NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C,
                     TPP_enzyme_N, phosphonates]) and not (phosphonatesHydrolase
                     or phosphonatesMeIsocitrateLyase))"
                     /neighbourhood="5000"
                     /product="phosphonate"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      5001..8549
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(phosphonates and minimum(1,
                     [2-Hacid_dh_C, Aldedh, Aminotran_1_2, Aminotran_5, AurF,
                     CTP_transf_like, DUF4992, Fe-ADH, HMGL-like, Metallophos_2,
                     NTP_transf_3, NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C,
                     TPP_enzyme_N, phosphonates]) and not (phosphonatesHydrolase
                     or phosphonatesMeIsocitrateLyase))"
                     /neighbourhood="5000"
                     /product="phosphonate"
                     /protocluster_number="1"
     cand_cluster    1..13549
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(phosphonates and minimum(1,
                     [2-Hacid_dh_C, Aldedh, Aminotran_1_2, Aminotran_5, AurF,
                     CTP_transf_like, DUF4992, Fe-ADH, HMGL-like, Metallophos_2,
                     NTP_transf_3, NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C,
                     TPP_enzyme_N, phosphonates]) and not (phosphonatesHydrolase
                     or phosphonatesMeIsocitrateLyase))"
                     /kind="single"
                     /product="phosphonate"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..13549
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="phosphonate"
                     /region_number="2"
                     /rules="(phosphonates and minimum(1, [2-Hacid_dh_C, Aldedh,
                     Aminotran_1_2, Aminotran_5, AurF, CTP_transf_like, DUF4992,
                     Fe-ADH, HMGL-like, Metallophos_2, NTP_transf_3,
                     NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C, TPP_enzyme_N,
                     phosphonates]) and not (phosphonatesHydrolase or
                     phosphonatesMeIsocitrateLyase))"
                     /tool="antismash"
     CDS             complement(34..1107)
                     /NRPS_PKS="Domain: NAD_binding_4 (10-144). E-value:
                     2.7e-07. Score: 21.8. Matches aSDomain:
                     nrpspksdomains_ctg11_485_NAD_binding_4.1"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Polysacc_synt_2"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) RmlD_sub_bind"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1010:NAD-dependent epimerase/dehydratase (Score:
                     103.5; E-value: 2.4e-31)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg11_485"
                     /sec_met_domain="Polysacc_synt_2 (E-value: 4.3e-107,
                     bitscore: 352.9, seeds: 77, tool: rule-based-clusters)"
                     /sec_met_domain="RmlD_sub_bind (E-value: 4e-07, bitscore:
                     24.8, seeds: 37, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSIFKDKVLLITGGTGSFGNAVLRRFLDSDIKEIRIFSRDEKKQD
                     DMRHHLQNPKVKFYIGNVRDRQSVDGAMMGVDYVFSAAALKQVPSCEFFPLQAVQTNVI
                     GTDNVLESAIAHGVKNVVVLSTDKAAYPINAMGISKAMMEKVAIAKGRALGEGAGTTIC
                     CTRYGNVMASRGSVIPLWVEQIKNGRPITVTDPNMTRFMMTLDDAVDLVIYAFEHGHNG
                     DLFVQKAPAATLDVLAQALKETYAQVDPKYGETEVKTIGTRHGEKLYETLVTREEMAKA
                     VDMGDYYRIPCDTRDLNYDKFFTEGNEDIARIEDYHSHNTARLDVEGMKKLLLKLRFIR
                     EDLGMEEKAKSAEIKSE"
     aSDomain        complement(676..1077)
                     /aSDomain="NAD_binding_4"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg11_485_NAD_binding_4.1"
                     /evalue="2.70E-07"
                     /label="ctg11_485_NAD_binding_4.1"
                     /locus_tag="ctg11_485"
                     /protein_end="144"
                     /protein_start="10"
                     /score="21.8"
                     /tool="antismash"
                     /translation="ITGGTGSFGNAVLRRFLDSDIKEIRIFSRDEKKQDDMRHHLQNPK
                     VKFYIGNVRDRQSVDGAMMGVDYVFSAAALKQVPSCEFFPLQAVQTNVIGTDNVLESAI
                     AHGVKNVVVLSTDKAAYPINAMGISKAMME"
     CDS_motif       complement(1024..1080)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ctg11_485_0001"
                     /evalue="1.70E-03"
                     /label="PKSI-KR_m1"
                     /locus_tag="ctg11_485"
                     /protein_end="28"
                     /protein_start="9"
                     /score="11.1"
                     /tool="antismash"
                     /translation="LITGGTGSFGNAVLRRFLD"
     CDS             complement(1126..2268)
                     /locus_tag="ctg11_486"
                     /transl_table=11
                     /translation="MDKNYQVCTHCVMDTTDSNLTFDENGVCDRCQEYEQHILPWWNHG
                     KGHEAELKAILEQVRISGKGKKYDCILGLSGGLDSCYMLHLAVKEWGLRPFVFHIDAGW
                     NLPVAEENIKKLCDKLNVHLHIQKLDFEELKQMQIAFFKTGHAGLDVPQDHAFIAQIDK
                     YSEELGVKYILNGYNICTEIVADPDSWFDGAGPTADKTYVKDVLKKHGNVKTKNYIYTT
                     GFKHKFVLPYIKGVKTLQLLNYVPFTKAEMLATLQREYDYQPYGQKHFEDLLTKFLEAW
                     WLPTRFGYDIRRAQLSSLIITGQMSREEALEILKNPPASDEECKKMFDEVAEKLAISKE
                     ELMSYHKLPKKYLHYKNNAWAFKIGIRLYQLLGLDKRIRK"
     CDS             complement(2277..3500)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Glycos_transf_1"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1045:glycosyl transferase group 1 (Score: 67.2;
                     E-value: 2.6e-20)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg11_487"
                     /sec_met_domain="Glycos_transf_1 (E-value: 1.7e-18,
                     bitscore: 62.3, seeds: 63, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MLTLLQISIEVNSGSVGRIAEQIGQVALAHGWKSYITYARNHLPS
                     QSMTIKIGTKWDVYWHGIMTRLFDTHCLHSTRATRRLIQQIEEIHPDIIQLHHIHGYFL
                     NMEVLFKYLSSISTPVVWVFHDCWSMTGHCAHFDYVGCEKWLTHCETCVQKKIYPGSVL
                     IDRSFKNYELKKKLFTSMENLTIVPVSQWLGMIVKKSFLKNYPINVIQNGIDLKLFSPQ
                     SLQSVCAMRNKLGLAEQTSVLLGVASIWDKRKGLEDFVQLYNMISEDWVIVLVGLSKTQ
                     LKEIPDGIIGIERTENVTQLATLYTLASVFINPTWEDTFPTTNLESLACGTPVITYRTG
                     GSVESVSDETGYIVEKGDIKGIKRAVAEIVKRGKEVYHHICRKRAVKYYDKNERFEDYI
                     KLYDTLLK"
     CDS             complement(3512..4204)
                     /locus_tag="ctg11_488"
                     /transl_table=11
                     /translation="MNQKEKEWLASLLLVRDILDRFSIKYILDTGTLLGAVRDRAFIPW
                     DDDIDIAIIDFLFDKHLAKTIGRELYLVGFDVIITANTVHLRRCNCEINLKSYLRNGTF
                     YNSTMTKVEGSDLLYSIYNCLRRLALYRNSHSFSRQVVNFIYFIISFMNYLGGAFLQDL
                     LIAKSKPKIRKIVIPAYLLSNTKDILFYDEYFKVPIDVNEYLTLRYGKNWNIPNRNYNY
                     ITDDLSLK"
     CDS             complement(4201..4992)
                     /locus_tag="ctg11_489"
                     /transl_table=11
                     /translation="MKELSCDEFKQIQIQILSEIKIFCEKNGLNYYLAYGTLLGAVRHQ
                     GFIPWDDDIDIVMPRIDYLKFEKLFKHDRFEFLSISKDATYPYHFGKVLDKNTILVDDS
                     SSSYDIGVNIDVFPIDGLPSSEMRKRIHCHFVWFLQNIATLKLMKYVRKRGMIKNIILA
                     FLKFIFIPFPLYTVLKAINNYAMKYSMEKSSEYLLEGAYKNREVVCASIFQSKMNVVFE
                     NESYSAPVGTNSWLMQLYGNYMEMPPVERRISTHNYKVLQK"
     CDS             complement(5001..6074)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: Fe-ADH"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg11_490"
                     /sec_met_domain="Fe-ADH (E-value: 5.5e-73, bitscore: 241.2,
                     seeds: 218, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MEQRCFLGESSIENLLLVLKEFSFSHLFLVRGRNSYETCGAKSIM
                     TAVFSELDCEVTEFFDFEENPKIEDLERGLLLLRKYSCSVIVAVGGGSVLDMAKLLRFF
                     YSYSGEPTSGKFEKEKDLLPLIVLPTTAGTGSEATHFAVLYKNKVKYSVEHNAILPDVA
                     IVYPPFTYNTPRYLTACAGFDALAQAIEAYWNAYATKESDEFAKRAIELLWPNLPLVVN
                     SPTNSMRNKVSEGAYWAGRAINITKTTAPHAFSYSFTTYYGYPHGHAVAMTFPFFWSIN
                     MDIHRIRKNISPSLYKQKIEYLKNLCNIDIGDYIEKRILLPLKLPENFNKYFILESVNR
                     QRLQNNPVDLDDFSELF"
     CDS             complement(6079..7209)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: TPP_enzyme_C"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: TPP_enzyme_N"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1055:pyruvate oxidase/decarboxylase (Score: 61.2;
                     E-value: 1.3e-18)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg11_491"
                     /sec_met_domain="TPP_enzyme_N (E-value: 3.8e-17, bitscore:
                     57.8, seeds: 75, tool: rule-based-clusters)"
                     /sec_met_domain="TPP_enzyme_C (E-value: 5.7e-19, bitscore:
                     63.8, seeds: 323, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MISSKFFIDSLCSMQMDFFTGVPDSLLKNVCAYITDHFVTERNVI
                     AANEGAAVGLAAGYYLATKKIPVVYMQNSGLGNAVNPLMSLTDKEVYNIPLLLLVGWRG
                     EPGVKDEPQHIKQGKVTLPLLEAMGIKYAIMSQNETEFLSQLNYANFYMNETHEPFAFV
                     IPKGTFEEYKLQQDGEVILPLKREAAIQLIASSLSKEDIIVSTTGMISRELFEYRTSAF
                     MEHEKDFLTVGSMGHASQIALGIALEKKKCKVFCFDGDGSTLMHMGSLAIIGSLHPDNY
                     VHVIFNNGAHDSVGGQPTVAFNIDLCKIAQACGYEAALSVSDSDSLCEALKRITYMHGP
                     ILLEVKVRKGARKDLGRPTTTPLQNKDTFMLFLNNQ"
     CDS             complement(7248..8549)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: PEP_mutase"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: CTP_transf_like"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: phosphonates"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1231:carboxyvinyl-carboxyphosphonate (Score: 205.9;
                     E-value: 1.2e-62)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg11_492"
                     /sec_met_domain="CTP_transf_like (E-value: 2e-13, bitscore:
                     46.1, seeds: 65, tool: rule-based-clusters)"
                     /sec_met_domain="phosphonates (E-value: 3e-119, bitscore:
                     392.7, seeds: 8, tool: rule-based-clusters)"
                     /sec_met_domain="PEP_mutase (E-value: 1.4e-63, bitscore:
                     209.9, seeds: 69, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNKKVYVGMSADIIHPGHLNIIHEAQKYGSVTVGVLTDAAIASYK
                     RLPYLTYEQRSLIVKNLKGVEEVIPQTTLDYVPNLELIKPDFVVHGDDWKDGIQKETRQ
                     RVIDTISKWGGKVIDVPYTKGISSTQLNTQLKEIGTTPEIRLKRLKRLISAKKIVRICE
                     SHSGLTGLIIENTSVEVNGIKREFDGMWSSSLTDSTSKGKPDIEAVDLTTRLHDLNDAL
                     ECTTKPVIFDGDTGGKIEHFVFTVRTLERLGISAVIIEDKIGLKKNSLFGTDAVQTQDT
                     IEGFCDKIKAGKRAQITADFMIIARIESFIAGKGLDDAMERALAYIEAGADGIMIHSKD
                     KSGKDIREFCMTLRKKHKSIPIVVVPTTYNHITEDELASWGVNVVIYANHMLRSAYPAM
                     LNTAKSILANARSYEANDLCMPVKEILELIPGTK"
     CDS             complement(8515..9783)
                     /locus_tag="ctg11_493"
                     /transl_table=11
                     /translation="MDFLSKKFLYVFLFWWGAYLFCSTFNPCDLFLVSNETYIILLGYV
                     VSFLIGFSIFPIKYNHSIYKNRANILAIKTNWWYVLAGISSIIILYNYICKYLLLLEVV
                     GADEARESLFESGLLFSTNYEIYLFQFLFTPFQTIVQFFLAYCIVFKSKFPPIYLMLFV
                     LYFFLYGYLGGGRANYLALFLYVILLFVLRTQIASKLHCNIRKYSFKFTFFLFFFCAII
                     FVIVSIQTTLRKGVTDIDGQTILMGFEELLSQFVWYMLGPIRALDYAFEYQYDSFLGLW
                     YGRATVGGFDTLLKMFIHALGGSYTTANQVIGGYLQEHLITVGYGITFNFAYTALIFYY
                     LDFGYFGILLWPFFLGITTRFTVYKFQKKATFARLILMLFFFYTAIFATFSWTFYKTAS
                     VVLIILLIIYQKYEQKSLCRHEC"
     CDS             complement(9840..10760)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Glycos_transf_2"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg11_494"
                     /sec_met_domain="Glycos_transf_2 (E-value: 5.4e-20,
                     bitscore: 67.3, seeds: 256, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKPLVSIICITYNQAEYLSSCLDSIFSQQVDFQVELIIHDDASTD
                     STTEIISQYIKKCPFQIKTILQKENQYSKGIDIFSKYIYPKVEGKYIAICEGDDYWTDS
                     RKLSIQIKMLEANQSFSATAHQSTVIYEKENREHLFCLLRKNIIKMDDVMGNRIFHTAS
                     FVFRSDIIPLLSIDIIPFAYDRFLFLVCSFYGDIYYFYDNMCVYRKSEIGITSHITYQI
                     HKRDLFVPKKLKEINSNFPYYRYMAYVNKAMLSSVDISLWNYICHSVTFLFYSFSYFPR
                     NIMDIYRWGYLTVWWMTKGRKFRMK"
     CDS             complement(10765..11307)
                     /locus_tag="ctg11_495"
                     /transl_table=11
                     /translation="MIGSTSFLTEEEIKSLGFKKYGDNLKISRFAHFYTPSTIEIGNNV
                     RIDDFCILSGNIKLGSNIHISAYCALYGAYGITMCDNTGLSPRATIFSSMDDFSGDFLI
                     GPIHDKSKINVQGGSVLLEEYVQIGSGSILFPKLKISKGCVVGAMSLVNKSLDEWGVYA
                     GIPVKKIKERRRGLLNL"
     CDS             complement(11315..12424)
                     /NRPS_PKS="Domain: Beta_elim_lyase (40-271). E-value:
                     6.1e-07. Score: 20.8. Matches aSDomain:
                     nrpspksdomains_ctg11_496_Beta_elim_lyase.1"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) DegT_DnrJ_EryC1"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1056:DegT/DnrJ/EryC1/StrS aminotransferase (Score:
                     290.8; E-value: 2.6e-88)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg11_496"
                     /sec_met_domain="DegT_DnrJ_EryC1 (E-value: 9.7e-96,
                     bitscore: 316.5, seeds: 38, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MENKVITVTSPLLPSLDDFIPYLQDIWNRKWLTNNGYYHQELEKA
                     LCEYLKVPYISLFTNGTLPLMCALQALRITGEVITTPYSFVATTHALWWNGIKPVFVDI
                     DPETCNIDPDKIEAAITPKTTAIMPVHVYGKPCDTERIQAIADKYGLKVIYDAAHAFGV
                     EVDGKSILNAGDMSTLSFHATKVYNTIEGGALICHDEKTKKRIDYLKNFGFAGETTVIA
                     PGINGKMDEVRSAYGLLNLKQVDAAIEARRQVAIMYRKGLEHVPGITFMEDMPGVRHNY
                     SYFPIFVDSEKYGMTRDELYFKMKERNILGRRYFYPLISEFSTYRGLESAKPENLLVAN
                     WVANSVICLPIYNSLSQIEIDRVISVISK"
     aSDomain        complement(11612..12304)
                     /aSDomain="Beta_elim_lyase"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg11_496_Beta_elim_lyase.1"
                     /evalue="6.10E-07"
                     /label="ctg11_496_Beta_elim_lyase.1"
                     /locus_tag="ctg11_496"
                     /protein_end="271"
                     /protein_start="40"
                     /score="20.8"
                     /tool="antismash"
                     /translation="ELEKALCEYLKVPYISLFTNGTLPLMCALQALRITGEVITTPYSF
                     VATTHALWWNGIKPVFVDIDPETCNIDPDKIEAAITPKTTAIMPVHVYGKPCDTERIQA
                     IADKYGLKVIYDAAHAFGVEVDGKSILNAGDMSTLSFHATKVYNTIEGGALICHDEKTK
                     KRIDYLKNFGFAGETTVIAPGINGKMDEVRSAYGLLNLKQVDAAIEARRQVAIMYRKGL
                     EHVPGITFM"
ORIGIN
        1 tttctttcct gttgtattat tcaaattaaa gacttattca ctcttgattt ccgcgctctt
       61 cgccttttcc tccattccga ggtcttcgcg gatgaagcgg agtttcaaaa gaagcttttt
      121 catgccctcc acatccaggc gggcagtgtt atggctgtga tagtcctcta tacgggcaat
      181 atcctcattg ccttccgtga agaacttgtc atagttcagg tcacgggtgt cgcaggggat
      241 gcggtaatag tcgcccatgt cgacagcctt tgccatctct tcgcgggtta ccagtgtctc
      301 atacagtttc tcgccgtggc gcgtgccgat ggtcttcacc tccgtctcac cgtatttcgg
      361 atcaacctgc gcgtatgttt ccttcaaggc ctgcgccagt acatccaagg tggcggcagg
      421 agccttctgc acgaacaggt caccgttatg cccgtgctca aacgcataga ttaccagatc
      481 cacggcatcg tccagcgtca tcatgaagcg ggtcatgttg gggtccgtta ccgtaatggg
      541 cctgccgttc tttatctgct ccacccacaa gggaattaca gaaccgcggc ttgccatcac
      601 attgccgtaa cgggtacagc agatggttgt accggctccc tcacccaacg cacggccctt
      661 ggctatggca accttctcca tcatggcctt gctgatgccc atggcattga tgggataggc
      721 agccttgtcg gtagaaagca ctactacatt ctttacacca tgcgctatgg cggattccag
      781 tacattgtcc gtaccgatca cattggtctg cacagcctgc aacgggaaga actcgcaact
      841 gggaacctgc ttcaaggcgg cagcagaaaa cacataatcc actcccatca tggcaccgtc
      901 cacagactga cggtcacgca cattaccaat gtaaaatttt actttgggat tttgcaggtg
      961 atgacgcatg tcatcctgtt ttttctcgtc acggctaaaa atacggattt ccttgatgtc
     1021 actatcaaga aaacgacgca atacagcgtt accaaaagat ccggtgcctc cggtgattaa
     1081 taaaactttg tccttgaata tagacataac tcactaatat ttttcctatt ttctaattct
     1141 tttatccaat cccaatagtt gataaagtct aataccaatc ttaaatgccc aggcattatt
     1201 cttatagtgc aagtattttt tcggcaattt atgatatgac attagttctt ccttactaat
     1261 agccagtttc tctgccactt catcaaacat ctttttacac tcctcatcag aagcaggagg
     1321 attctttaaa atttcaagag cttcttcacg gctcatttgc cctgtaataa tcaaacttga
     1381 taattgcgcc ctacgaatat catagccaaa ccgagtagga agccaccaag cctccagaaa
     1441 cttagtaagc aaatcctcaa aatgtttttg cccataaggt tgataatcat attcacgttg
     1501 aagggttgcc aacatttcag cttttgtaaa aggaacataa tttaggagtt gcaacgtctt
     1561 tactcctttt atgtatggaa gaacaaattt atgtttaaaa cctgtagtat aaatataatt
     1621 cttagtcttc acattgccgt gcttttttaa tacatccttt acataggttt tatctgctgt
     1681 aggccctgca ccatcaaacc aagagtctgg gtcagcaaca atttcagtac aaatattata
     1741 accattcaaa atgtatttca cacccaattc ttccgaatat ttatctattt gagcaatgaa
     1801 agcatggtct tgaggaacat ccaacccggc atgtccggtc ttgaaaaatg caatctgcat
     1861 ctgcttcaac tcttcaaaat ccaacttctg aatatgaaga tggacattca gtttatcaca
     1921 gagcttttta atattctctt ctgctacagg cagattccat ccggcatcaa tatgaaacac
     1981 aaagggacga agcccccact ctttgactgc aagatgcagc atataacaac tatccaatcc
     2041 accactcagt cctaaaatac aatcgtattt tttacctttt cctgagattc ttacttgctc
     2101 caaaatggct ttcaattcag cttcgtggcc tttgccatgg ttccaccaag gtaatatatg
     2161 ttgttcatac tcttggcatc tgtcacatac accattttca tcaaaagtca gattagaatc
     2221 agtcgtatcc attacacaat gggtacatac ttggtaattt ttatccatac tcttttctac
     2281 tttaacaaag tatcatacaa ttttatataa tcttcaaagc gttcattttt atcataatat
     2341 ttaacagctc gttttcgaca tatatgatga taaacttctt ttcctcgctt tactatttca
     2401 gctacagccc tctttatgcc ttttatatcc cctttttcta caatatatcc agtttcatct
     2461 gatacagact caacacttcc gccagtccga tatgtaatga caggtgttcc acaagctaaa
     2521 gattctagat ttgttgttgg aaatgtatct tcccaagttg ggttaataaa gacagaagct
     2581 aaagtgtaca aagtagctaa ttgagtaaca ttttcagttc tctcaattcc aattatgcca
     2641 tcggggattt ccttcagctg cgtttttgat aatcctacta aaacaataac ccaatcttca
     2701 gaaatcatgt tatacaattg aacgaaatcc tcaagcccct tgcgtttatc ccaaatacta
     2761 gctactccta ataaaacact agtttgctct gctaatccca atttatttct catggcacat
     2821 acactctgca aggattgagg agaaaaaagt tttagatcaa ttccattttg aattacattt
     2881 attggataat ttttcaagaa tgatttcttt acaatcattc ctagccactg tgataccggc
     2941 acaatagtca aattttccat agatgtaaac aacttttttt ttagttcata atttttaaaa
     3001 gacctatcta ttaatacact tccaggatat attttctttt gtacgcaagt ctcacaatgc
     3061 gtcaaccatt tctcacatcc gacatagtca aaatgagcac aatgcccagt cattgaccaa
     3121 cagtcatgaa aaacccatac cacaggtgta gaaatagaag ataaatactt aaataaaacc
     3181 tccatattca aaaaataccc atgaatgtga tgaagttgaa taatatcagg atgaatttcc
     3241 tcaatctgtt gtattaatct tctagtggct cgagtagagt gaagacaatg agtatcaaac
     3301 aaacgtgtca taattccatg ccaatacaca tcccattttg tacctatttt aatagtcata
     3361 gattgactag gcaaatgatt acgagcataa gttatataac tcttccaacc atgtgcaaga
     3421 gctacttgcc ctatttgttc agcaatacgt cctacagaac cagaattcac ctctatacta
     3481 atttgaagaa gagtaagcat aaagattaaa actattttag ggataaatca tctgttatat
     3541 aattataatt tctattagga atattccaat tcttgccata tcgtaaagtc aaatattcat
     3601 tcacatcaat tggaacttta aaatactcat cataaaagag aatatctttt gtattcgaca
     3661 acaaataggc aggaattaca atcttacgaa ttttaggttt agatttagct ataagtaaat
     3721 cctgcaaaaa agccccacct aaatagttca taaacgaaat tataaaataa ataaaattca
     3781 ctacttgacg agaaaaagaa tgagagtttc tataaagagc aagtcgtctt aaacagttat
     3841 aaattgaata taataaatca gatccttcta cttttgtcat tgttgaatta taaaaagtac
     3901 catttcgcaa atatgatttc aaatttattt cgcaattaca acgacgtaga tgaactgtat
     3961 ttgcagtaat aattacatca aaccctacta aatagagctc tcttcctatt gttttcgcta
     4021 aatgtttatc aaataagaaa tcaattattg cgatatcaat atcatcatcc caaggaataa
     4081 atgctctgtc tcggactgca cccaataatg tacctgtatc taaaatatat tttatagaga
     4141 atctatccaa tatatcccgt acaagtaata aggatgctaa ccattctttt tctttctgat
     4201 tcatttctgc aatactttat aattatgcgt tgaaatccgt ctttcaacag ggggcatttc
     4261 catataattt ccatagagtt gcataagcca tgaatttgtc ccaacaggtg cactataaga
     4321 ctcattttca aacacaacat tcattttact ttgaaaaata gaagcacaaa cgacctccct
     4381 attcttataa gctccctcca aaagatattc tgatgatttc tccatagaat atttcattgc
     4441 atagttgttt atagctttta aaactgtata taatggaaag ggaataaaaa taaatttcaa
     4501 gaatgcaaga atgatatttt taatcattcc tctttttctc acatatttca ttaatttaag
     4561 agttgcaata ttttgcaaaa accaaacaaa atgacaatgt attctttttc tcatttctga
     4621 acttggcaga ccatctatcg ggaaaacatc tatattaacc ccgatatcat aggaagagga
     4681 agaatcgtct actaatattg tatttttatc taaaactttt ccaaaatgat aaggataagt
     4741 agcatcctta cttattgaaa gaaattcgaa tctatcatgt ttaaataact tttcaaattt
     4801 taaataatca atacgaggca ttactatatc aatatcatca tcccaaggaa taaaaccttg
     4861 atgcctcaca gctcccaata aagttccata cgctaaataa taattcaacc catttttttc
     4921 acaaaatatt tttatttcac tcaatatttg tatctgaatt tgcttaaatt catcacaaga
     4981 caactccttc ataatatgtt tcaaaacaat tcactaaaat catctaagtc cactggatta
     5041 ttttgcaatc gctgcctatt tacactctct aaaatgaaat acttattaaa attttccggc
     5101 aacttcaatg gcaataaaat tcttttttct atatagtcac caatatcaat attacacaga
     5161 ttttttaaat attcaatctt ttgtttatac agagatgggg atatattctt tctaattcta
     5221 tgtatatcca tatttattga ccaaaaaaaa ggaaatgtca ttgctactgc atgcccatgt
     5281 ggatacccat aataagttgt aaatgaataa gagaaagcat gaggcgcagt cgttttagtg
     5341 atatttatag cacgaccagc ccaataagcc ccctccgaca ctttatttct catactatta
     5401 gtaggagaat ttacaactaa tggtaaatta ggccacaaaa gttcaattgc tctcttagca
     5461 aattcatctg actcttttgt agcataagca ttccagtaag cctctatagc ctgggccaaa
     5521 gcatcaaaac ctgcacaagc tgtcaaatac ctcggagtat tgtatgtgaa tgggggatat
     5581 acaattgcaa catcaggtaa aatagcatta tgttctacag aatatttcac tttattttta
     5641 tacaatactg caaaatgggt cgcctcactt cccgtaccgg ctgtagtggg aagaactatc
     5701 aatggaagca aatctttctc tttttcaaat ttaccacttg taggctcacc agaataagaa
     5761 taaaaaaagc gaagtagttt agccatatcc aatacactac ctccaccaac agcgacaatg
     5821 acagaacaag agtacttacg taatagtaat aaccctcttt ccaaatcttc gattttagga
     5881 ttttcttcaa aatcaaaaaa ctccgttact tcacaatcta attcactaaa aacagcagtc
     5941 ataatagatt tggcaccaca agtctcataa gagtttctgc cacgcaccaa aaaaaggtga
     6001 gaaaaagaaa actccttcaa aactaagagc aaattttcga ttgaagactc tcccaaaaaa
     6061 caacgctgct ccataaaatc attgattatt caagaaaagc ataaaggtat ctttattttg
     6121 taagggagta gtagtcggac gtcccaaatc cttacgtgct ccttttctta ccttaacctc
     6181 taacaaaata ggaccatgca tatacgtaat tcttttaagg gcttcacata agctatcact
     6241 gtctgaaaca gataaagctg cctcataacc gcaagcctga gctattttac acaaatcaat
     6301 attaaaggca actgtgggtt gtccacctac agaatcatga gccccattgt taaaaataac
     6361 atgtacatag ttgtctggat gtaaggaacc tattattgca agcgatccca tatgcattaa
     6421 agttgatcca tcaccatcga aacaaaaaac tttgcatttt tttttctcaa gagcaatgcc
     6481 taatgctatt tgagaagcat gccccataga acctactgtc aaaaaatcct tctcatgttc
     6541 cataaaagca gaagtacggt attcaaataa ctcacgtgat atcatacctg tagtagagac
     6601 aataatatcc tcttttgaca atgaagaagc tataagttga atagcagcct ctcttttcaa
     6661 aggtaatatc acctctccat cttgttgaag cttatactcc tcaaaagttc ctttgggaat
     6721 tacaaaagcg aaaggttcat gtgtctcatt catataaaaa ttggcataat tcaattgaga
     6781 taagaattct gtttcatttt gagacataat ggcatatttt atacccatag cttcaagtaa
     6841 aggaagtgtc actttgccct gcttaatatg ctggggctca tcttttactc ctggctcgcc
     6901 acgccatccc acaagtaaca ataaaggaat attgtaaact tctttatccg ttaatgacat
     6961 taaaggattg acagcattgc caagaccgga attttgcata taaacaactg gtattttttt
     7021 tgtggctaaa taatatcctg cagctaaacc aactgcagct ccctcattgg ccgcgataac
     7081 atttcgttct gtaacaaaat gatcggtgat atatgcacac acatttttca ataaagaatc
     7141 gggaactccc gtaaagaaat ccatttgcat ggagcaaaga gaatcaatga aaaattttga
     7201 agatatcata ataacaagaa tctcaaatta atagaatata aacgaagtta tttagtaccc
     7261 ggaatcaatt ctaatatttc tttgacaggc atacataaat cattagcttc atatgaacgg
     7321 gcattagcca aaatggactt tgctgtattt agcatggcgg gatatgcact tctaagcata
     7381 tgattggcat aaattactac attcactccc catgatgcta attcatcttc tgttatatga
     7441 ttatatgttg taggaacaac cacaataggt atggatttat gcttcttacg caaagtcata
     7501 cagaactccc taatatcctt acccgattta tccttactat gaatcataat gccatcagca
     7561 ccagcctcaa tatatgctaa tgcacgttcc attgcatcat ccagaccttt acctgcaata
     7621 aagctctcaa tacgagctat tatcataaaa tcagccgtta tctgagcacg cttaccagcc
     7681 tttatcttat cgcaaaaacc ttcaattgta tcctgggttt gaacagcgtc tgttccaaaa
     7741 agcgagttct tcttcagacc aattttatct tcaataataa ctgctgatat ccctaagcgc
     7801 tccaaagtac gaactgtaaa tacaaaatgc tctatttttc cacctgtatc tccatcaaaa
     7861 attacgggtt tagttgtaca ttccaaagcg tcattcagat catgaagacg ggtagtcaaa
     7921 tcaacagctt caatatccgg ttttccttta gaggtagaat cagtaagact actagaccac
     7981 attccatcaa actcacgttt aataccgtta acctcaacac tcgtattttc gataattaaa
     8041 cctgttaatc cactatgaga ctcacatatt cgaacaattt tcttggcaga aatcagacgt
     8101 tttagacgtt tcaagcgaat ttcaggggta gtaccaattt cctttaactg ggtatttaac
     8161 tgggtggaag atataccttt tgtataagga acatctatca ctttaccacc ccatttagaa
     8221 attgtatcta tgacacgttg acgagtttct ttttgaatac catccttcca atcatcacca
     8281 tgaactacaa aatcaggttt tatcaactct aaattaggaa cataatcaag agttgtttgg
     8341 ggaatcactt cttcaacgcc tttcaaattc ttcacaatta gcgaacgctg ttcataagtc
     8401 aaatatggca aacgtttata actagcaata gcagcatctg tcaatactcc aacagttaca
     8461 gaaccatatt tctgggcctc gtgaataata ttcaaatgcc ctggatgaat aatatcagca
     8521 ctcatgccga cataaacttt tttgttcata tttctggtat ataattagta atataattaa
     8581 cactactgaa gctgttttat aaaaagtcca tgaaaaagtc gcaaatattg cagtataaaa
     8641 aaagaataac attaatatca atcttgcgaa agttgctttt ttctgaaact tataaacagt
     8701 aaaccgagtt gttattccca aaaagaatgg ccacaacaat attccaaagt aaccaaaatc
     8761 taaataataa aatatcaatg ctgtataagc aaaattgaaa gttataccat aaccgacagt
     8821 tattagatgt tcttgaagat agccacctat aacttgatta gcggttgtat aacttcctcc
     8881 taacgcatga ataaacatct ttaaaagtgt atcaaatcca ccaacagttg ctcttccata
     8941 ccacaagcct aaaaaggaat catactgata ctcaaaagca taatctaacg ctctaatagg
     9001 tcccaacata taccatacaa attgggacaa caattcttca aatcccataa ggatggtttg
     9061 tccatctata tcagtgactc cttttctcaa tgtagtttga atagaaacaa tcacaaaaat
     9121 tattgcacaa aagaaaaaaa ggaaaaaagt aaatttgaaa gaatattttc gaatattgca
     9181 atgtaatttt gaagcaatct gggttcttag tacaaataac aatataacat ataaaaagag
     9241 agctagatag ttagcccttc ctcctcctaa atagccataa agaaaaaaat agagaacaaa
     9301 taacattaaa tatataggag gaaacttgct cttgaagact atacaataag ctaaaaagaa
     9361 ctgcactatt gtttgaaaag gagtaaacag aaactgaaat aaatatatct cataatttgt
     9421 actaaacaga agcccagatt caaaaagaga ctctcttgct tcatctgcac ctaccacctc
     9481 taacaacaac aaatacttac aaatataatt atatagaata atgatacttg atattcctgc
     9541 taacacatac caccaattag tttttatggc taaaatatta gctctatttt tataaattga
     9601 atgattgtat tttataggaa atatactaaa acctattaaa aaagaaacaa cataccctaa
     9661 caatataatg tatgtttcat ttgaaacaag aaataagtcg caaggattaa atgtagaaca
     9721 aaataaatat gcaccccacc aaaacaaaaa aacatataag aatttttttg ataaaaaatc
     9781 cattctactt ttttttaaaa gtaaaaatat gagagtaaaa aagcagaata ctatcaaact
     9841 catttcatac gaaattttcg acctttagtc atccaccaaa ctgtcaaata cccccaccta
     9901 tatatatcca taatatttct aggaaagtat gagaaagaat agaacaaaaa tgttacagaa
     9961 tggcatatgt aattccagag agagatatcc actgaagaca acatagcctt attaacgtaa
    10021 gccatatatc tataatatgg aaaattagaa tttatttctt tcaacttttt cgggacaaat
    10081 aaatcccgtt tgtgaatttg ataagttata tgactagtaa tacctatttc gctctttcga
    10141 tatacacaca tattatcata aaaataatat atatcaccat aaaacgaaca aactagaaat
    10201 aaaaaacgat cataagcaaa aggaattatg tctattgaaa gcaagggaat tatgtcactt
    10261 ctaaaaacaa aagatgcagt atgaaaaata cgatttccca taacatcatc catttttatt
    10321 atattctttc gtaatagaca aaacaaatgt tccctatttt ctttttcata tataacagta
    10381 gattgatgag ctgttgccga aaaagattga tttgcttcta acattttaat ttgaatagat
    10441 agtttccgag aatccgtcca ataatcatct ccttcacaaa tagcaatata tttaccttcg
    10501 accttaggat atatatattt tgaaaaaata tcaattcctt tagaatattg attctctttt
    10561 tgtagaatag ttttaatctg aaaagggcat ttcttgatat actgagaaat tatttcagtt
    10621 gtactatctg tagaagcatc atcatgtatt atcaattcta cttgaaaatc cacctgctga
    10681 gaaaaaatac tatctaagca tgaagataaa tattcagctt gattataagt aatgcaaata
    10741 atacttacca atggcttcat aaaactataa attcaataat cctctacggc gttctttaat
    10801 tttttttaca ggtattcctg catatacccc ccattcatca aggcttttat taaccaaaga
    10861 catagctcca actacacacc ccttagatat tttcaacttt ggaaacaata tacttcctga
    10921 accaatttgc acatattctt ctaacaaaac ggaaccaccc tgaacattta ttttgctttt
    10981 atcatgtatt ggacctatta aaaaatcacc actaaaatca tccattgagc taaaaattgt
    11041 tgcacgagga gaaagtcctg tattatcaca catcgttatt ccataggctc cataaagtgc
    11101 acaataagca gaaatatgaa tatttgatcc aagtttaata ttcccagata atatacaaaa
    11161 gtcgtcaata cggacattat tacctatttc aatagtagaa ggggtataaa aatgagcaaa
    11221 acgactaatt ttcaaattat ctccatattt tttaaaccct aacgatttta tttcttcttc
    11281 cgttaaaaaa gacgtactac caatcataaa aagattattt cgatataacc gatattactc
    11341 tatcgatttc tatttgtgat aaagaattat atataggcaa acatattaca ctatttgcca
    11401 cccaatttgc tactaataga ttctcaggct tagccgattc caatcctcga taagtagaaa
    11461 attcgcttat caacggatag aaatacctac gccccaatat attccgttcc ttcatcttaa
    11521 aataaagttc atcgcgtgtc atgccatatt tctcagaatc cacgaatatg ggaaagtaag
    11581 agtaattatg acggactccg ggcatatctt ccataaaagt gataccaggt acatgttcca
    11641 agcctttacg atacatgata gccacttgac gacgagcttc aatagctgca tccacttgtt
    11701 tcaaattcaa caaaccataa gcactacgta cttcgtccat cttgccattg atacccggag
    11761 ctatgacagt cgtttccccc gcaaaaccga aattcttcaa atagtcgata cgctttttag
    11821 tcttctcatc atgacaaatc aaagcaccac cttcaatcgt attgtaaact ttggtcgcat
    11881 gaaaactcaa ggttgacata tcaccggcat tcagaattga ctttccatcc acttctaccc
    11941 caaaagcatg ggcagcatca taaatgacct tcaaaccgta tttgtccgct atcgcctgga
    12001 tacgctctgt atcacaaggc ttgccataaa catgtaccgg cataatcgcc gttgtcttgg
    12061 gggttattgc cgcttctatt ttgtccggat caatgttaca agtttctggg tcaatatcca
    12121 caaataccgg tttgattcca ttccaccaca aagcatgggt ggtagctaca aagctatacg
    12181 gagttgttat cacctcacca gtaatacgca atgcttgcag agcacacatc aaaggcagtg
    12241 tgccattggt aaaaagactg atataaggca ccttcaaata ttcacacaag gctttctcca
    12301 attcttgatg ataataaccg ttattggtca gccacttacg gttccaaata tcctgtaaat
    12361 aaggaatgaa atcgtcaagc gaaggaagta atggagaagt aactgtaatc actttatttt
    12421 ccatcttact ataaaaatat atactgattt ctattttttg tgaagagccg acaacccaag
    12481 ccgttttacc tcaagatact ctggtaatct taatctttca taaacagcaa aagctaatgt
    12541 caaaccaaca ataatctgaa tgggcaattg aatataaacg gatatatcca ataaggaaaa
    12601 aagccacatg acagcagcaa ttgtcaaaga aactgcaaaa accggaagca catccttgat
    12661 ttgttctatg gtagaatagc gtatcaagtc ggcagaatag tggctattta agaaataggc
    12721 tatgaaagag gttaagacac tcccccacag catatattcg atgccataaa aaatacctat
    12781 cagaatagga aacaccgcaa tggtcttctt tatgatttct aatttcagaa acaagtccga
    12841 acgtcctttc acctgcaaga tattcagatt gatggcatga agcggataaa gcataccact
    12901 gaaacaaata atctgcagaa aggaaacagc agtcaaccat ttctcaccga tcagaattat
    12961 aatcaaaggt ttagccacag ctgcaagtcc cagcatgcaa gcgaatgtca caagcattgt
    13021 agtctttatt atctgccgat aagcttcgcg caagcgctcc ggttcttctt gaatggaact
    13081 aagcaccgga taactgacac gctggacaat actggtcaga ttactggaaa atatcgtatt
    13141 gaactgctct gcacgagtat attgccccaa ctgtgcagaa ctgtaacaac ggcctataac
    13201 cacataataa acattcttgt aaagagtatc caataatccg gacaacaaga gcttatagcc
    13261 aaagccgaac atttccttga agctttttac ggaaaattcc cattggggca tccatttaca
    13321 gaatatccaa agaaacagag aattcagaat ctgccgggaa agctgttgcc acaccaaact
    13381 ccatactcca aagcccacta tagccatgcc tacgccaacc aatccacctg aaacagaaga
    13441 gattatggat actttggtct gtgtcttaaa atcaacatct cttactaata tggtacgggg
    13501 aatgataccc aatgcattaa caatcagaat cagccctatt acccttaac
//
