LOCUS       c00051_gnlPro..        16754 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|KFACAOEJ_83.
ACCESSION   c00051_gnlPro..
VERSION     c00051_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-03 22:43:40
            Original ID  :: gnl|Prokka|KFACAOEJ_83
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 16754
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..16754
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[9946:13504](-)"
                     /cutoff="5000"
                     /detection_rule="cds(POR and POR_N and PFOR_II and EKR and
                     Fer4_16 and TPP_enzyme_C)"
                     /neighbourhood="10000"
                     /product="PFOR_II_pathway"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      complement(9947..13504)
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="5000"
                     /detection_rule="cds(POR and POR_N and PFOR_II and EKR and
                     Fer4_16 and TPP_enzyme_C)"
                     /neighbourhood="10000"
                     /product="PFOR_II_pathway"
                     /protocluster_number="1"
     cand_cluster    1..16754
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="cds(POR and POR_N and PFOR_II and EKR and
                     Fer4_16 and TPP_enzyme_C)"
                     /kind="single"
                     /product="PFOR_II_pathway"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..16754
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="PFOR_II_pathway"
                     /region_number="1"
                     /rules="cds(POR and POR_N and PFOR_II and EKR and Fer4_16
                     and TPP_enzyme_C)"
                     /tool="gutsmash"
     CDS             288..1514
                     /locus_tag="ctg51_1"
                     /transl_table=11
                     /translation="MFFFLIVPLFLALFYKPIAYLCGRFLNNKSKRENYFMKHISNFLR
                     SKSWNVFLFLYLALPLFAQKEYKIDQVSVVNVGDGRLLFQELKTEKALNGEHRIIDGYH
                     SAYVLASFKDGFYDGGYKEYVDNILITEGSYKEGRKDGLFKINSKFDGKLKEEKSYKEG
                     KLDGTSKSYFTTGKVESERNFRMGKEHGKQLSYESDGTLRKEHNYKDGKQVGKQYTFLK
                     GTYDLYETVYFNEEGFQDGEYSSVFTFGSPRILGSYKNGKKNGRWTTFAESGDTLMIET
                     YLDGKEDGLHVSFANGSGVRQKEYYMKNDRKDGLYREYNLENGELRYEATYQAGRLHGK
                     ERRLIVSNRFDYWETSTYVNGRQNGPFEARYVKNDQLRECGEYKNGHRVGRWKRYTIDG
                     KLEKEWDEN"
     CDS             1847..4600
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peripla_BP_1"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1042:Periplasmic binding proteins and sugar binding
                     domain of LacI family (Score: 64.3; E-value: 4.2e-20)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg51_2"
                     /sec_met_domain="Peripla_BP_1 (E-value: 7.4e-21, bitscore:
                     64.3, seeds: 6, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKTMRYLKWMLVLFGLIGMTACRQDTPRFRIGVAQCSDDSWRHKM
                     NDEILREAMFYNGVSVEIRSAGDDNSKQAEDVHYFMDEGVDLLIISANEAAPMTPIVEE
                     AYQKGIPVILVDRKILSDKYTAYIGADNYEIGRSVGNYIASSLKGKGNIVELTGLSGST
                     PAMERHQGFMAAISKFPDIKLIDKADAAWERGPAEIEMDSMLRRHPKIDAVYAHNDRIA
                     PGAYQAAKMAGREKEMIFVGIDALPGKGNGLELVLDSVLDATFIYPTNGDKVLQLAMDI
                     LEKKPYPKETVMNTAVVDRTNAHVMQLQTTHISELDKKIETLNGRIGGYLSQVATQQVV
                     LYGSLIILLLVAGLLLVVYKSLRSKNRLNKELFKQKQQLEEQRDKLEEQRDQLIQLSHQ
                     LEEATHAKLVFFTNISHDFRTPLTLVADPVEHLLADKTLSGDQHRMLMLIQRNVNILLR
                     LVNQILDFRKYENGKMEYTPVTVDVLSSFEGWNESFQAAARKKHIHFSFDSMPDTDYHT
                     LADMEKLERIYFNLLSNAFKFTPENGKIAVRLSSLSKEDKRWIRFTVANTGSMISAEHI
                     RNVFDRFYKIDMHHTGSGIGLALVKAFVEMHGGMISVESDEKQGTVFTVELPVQSCEAV
                     AAEPDTTLVSADSRTTDVLLAEEEELEKGYDSSKPSVLIIDDNEDIRSYVHTLLHTDYT
                     VIEAADGSEGIRKAMKYVPDLIISDVMMPGIDGIECCRRLKSELQTCHIPVILLTACSL
                     DEQRIQGYDGGADSYISKPFSSQLLLARVRNLIDSHRRLKQFFGDGQTLAKEDVCDMDK
                     DFVERFKSLIEEKMGDSGLNVEDLGKDMGLSRVQLYRKIKSLTNYSPNELLRIARLKKA
                     ASLLASSDMTVAEIGYEVGFSSPSYFAKCYKEQFGESPTDFLKRKG"
     CDS             4628..4960
                     /locus_tag="ctg51_3"
                     /transl_table=11
                     /translation="MKDYKVDKESFSESFRKEVYEVVSQIPVGKVSTYGGIALLLGAPQ
                     CSRMVGRALKEVPDELSIPCHRVVNSTGRLVPGWVEQKQLLLAEEVSFKANGCVNLKEH
                     LWHVDE"
     CDS             complement(4923..6209)
                     /locus_tag="ctg51_4"
                     /transl_table=11
                     /translation="MFNRAITIFLGKDNCHYTTKEKQTGTATLDDKSQVQFLSKKNPKM
                     PFFYSRRNLYMIGFLLAFIVTLLEFIRGRHQNFMVFSDATQFFWQGISPYTTEFVEAHG
                     RYFLYSPVFTVLFAPFAYLPAWLGPFAWNLFNYSLFFMAIFTLPQQFTQQQKCRMFLFL
                     LLILGQSLLSFQYNITVAYLFLFAYTLLEKDRGFLAVLLIMISGCTKVYGIFELALLLC
                     YPHVWRNFGYAVTMGIVLLALPLIKIAPADLLPYYEEWCHSLAVHQSAGAYDSFFYARP
                     IAAWTLPHFRALQIGMLGLLTLLFLGNFRKWSSFAFRAQALGILMGWVVLLSDSAEKHT
                     YIIALAGFMLWYWSRPTRTATDKILFWCCFVLLCIVPIDIFVPIPIRDFITRTLWLHVW
                     VFFIVWIRMIWLTFLASFIHPRATNVLSD"
     CDS             6682..7908
                     /locus_tag="ctg51_5"
                     /transl_table=11
                     /translation="MSKIEIKDLYLVFGNEKQKALKMLKEGKTKSEILKATGCTVAVKD
                     ANLSINEGEIFVIMGLSGSGKSTLLRCINRLIRPTSGEVIINGTDIAKVSDKELLQIRR
                     KELAMVFQNFGLLPHRSVLHNIAFGLELQGVKKGEREQKAMESMQLVGLKGYENQMVSE
                     LSGGMQQRVGLARALANNPEVLLMDEAFSALDPLIRVQMQDELLTLQSKMKKTIVFITH
                     DLSEAIKLGDRIAIMKDGEIVQIGTSEEILTEPANAYVERFVENVDRSKIITASSVMVD
                     KPIVARLKKEGPEVLIRKMRERNLTVLPVVDSNNLLVGEVRLNDLLKLRKEQIRSIESV
                     VRHEVHSVLGDTVLEDILPLMTKTNSPIWVVNENREFEGVVPLSSLIIEVTGKDKEEIN
                     EIIQNAIEL"
     CDS             7905..8735
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) BPD_transp_1"
                     /gene_functions="transport (smcogs)
                     SMCOG1004:Binding-protein-dependent transport system inner
                     membrane component (Score: 91.7; E-value: 1.6e-28)"
                     /gene_kind="transport"
                     /locus_tag="ctg51_6"
                     /sec_met_domain="BPD_transp_1 (E-value: 2.9e-29, bitscore:
                     91.7, seeds: 81, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MINIGQYIETAINWLTEHFASFFDALSMGIGGFIDGFQHVLFGIP
                     FYITIAVLAALAWFKSGKGTAVFTLLGLLLIYGMGFWEETMQTLALVLSSTCLALLLGV
                     PLGIWTANSDRCNKIMRPVLDFMQTMPAFVYLIPAVLFFGLGTVPGAFATIIFAMPPVV
                     RLTGLGIRQVPKNVVEASRSFGATPWQLLYKVQLPLALPTILTGINQTIMMSLSMVVIA
                     AMISAGGLGEIVLKGITQMKIGLGFEGGIAVVILAIVLDRITQGMADNRKSKKK"
     CDS             8763..9623
                     /locus_tag="ctg51_7"
                     /transl_table=11
                     /translation="MNKIKMIAAMFIAGILLTFVSCGDNGKSKKISIAYANWSEGIAMT
                     NLAKAIFEDQGYDVKLLNADLAPIFTSISRKKADVFMDVWMPVTMEDYMKQYGDKLEVI
                     GDIYDGARIGLVVPDYVTINSIEELNAEKERFSGQIVGIDAGAGIMKATDQAIKDYGLD
                     YKLMTSSGPAMTASLKKAIDKKDWIVVTGWTPHWMFDRFKLKVLQDPKLIYGNTESIHT
                     IAWKGFSEKDPFAAELLGNIRLTDAEISSLMTALEEAQTTERQAARQWMEEHQELVNSW
                     IPEKD"
     CDS             complement(9634..9822)
                     /locus_tag="ctg51_8"
                     /transl_table=11
                     /translation="MIGFVIWIIGLILTFRAAIEIWNINAAVEKRLIAIVLIVLTSWLG
                     LLFYYFYGKERMAGWLK"
     CDS             complement(9947..13504)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     PFOR_II_pathway: TPP_enzyme_C"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     PFOR_II_pathway: Fer4_16"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     PFOR_II_pathway: POR"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     PFOR_II_pathway: EKR"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     PFOR_II_pathway: PFOR_II"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     PFOR_II_pathway: POR_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_4"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg51_9"
                     /sec_met_domain="PFOR_II (E-value: 5e-19, bitscore: 58.2,
                     seeds: 27, tool: rule-based-clusters)"
                     /sec_met_domain="POR_N (E-value: 7.1e-83, bitscore: 267.4,
                     seeds: 31, tool: rule-based-clusters)"
                     /sec_met_domain="POR (E-value: 7.8e-32, bitscore: 100.3,
                     seeds: 86, tool: rule-based-clusters)"
                     /sec_met_domain="TPP_enzyme_C (E-value: 1.4e-12, bitscore:
                     37.2, seeds: 323, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_16 (E-value: 2.5e-12, bitscore: 37.2,
                     seeds: 227, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4 (E-value: 4.6e-08, bitscore: 22.4,
                     seeds: 528, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_4 (E-value: 2.5e-05, bitscore: 14.4,
                     seeds: 79, tool: rule-based-clusters)"
                     /sec_met_domain="EKR (E-value: 1.2e-25, bitscore: 78.8,
                     seeds: 127, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTKQKKFITCDGNQAAAHISYMFSEVAAIYPITPSSTMAEYVDEW
                     AAAGRKNIFGETVLVQEMQSEGGAAGAVHGSLQAGALTTTYTASQGLLLMIPNMYKIAG
                     EFLPCVFHVSARTLASHALCIFGDHQDVMSARQTGFAMLAEGSVQEVMDLAGVAHLATI
                     KSRVPFMNFFDGFRTSHEIQKIEMLENDDLAPLIDQEALAEFRARALNPMKPVARGMAE
                     NPDHFFQHRESCNNYYEAVPAIVEEYMNEISKITGRKYGLFDYYGAEDAERVIIAMGSV
                     TEAAREAIDHLVANGEKVGMVAVHLYRPFSAKHFLAAVPKTAKSIAVLDRTKEPGANGE
                     PLYLDVKDCFYGAENAPVIVGGRYGLGSKDTTPAQIISVFENLAMPMPKNHFTIGIVDD
                     VTFTSLPQKEEIALGGEGMFEAKFYGLGADGTVGANKNSVKIIGDNTDKHCQAYFSYDS
                     KKSGGFTCSHLRFGDTPIRSTYLVNTPNFVACHVQAYLHMYDVTRGLRKNGSFLLNTIW
                     EGEELAKNLPNKVKKYFAQNNISVYYINATQIAMEIGLGNRTNTILQSAFFRITGVIPV
                     DQAVEQMKKFIVKSYGKKGEDVVNKNYAAVDRGGEYKTLTVDPAWANLPDDAKAENNDP
                     AFINEVVRPINAQDGDLLPVSAFKGIEDGTWYQGTSKYEKRGVAAFVPEWNAENCIQCN
                     KCAYVCPHASIRPFVLDAEEQKGAKFEQLKAVGKAFDGMTFRIQVDVLDCLGCGNCADI
                     CPGNPKKGGKALTMKHLESQLAEADNWTYCAENVKSKQHLVDIKANVKNSQFATPLFEF
                     SGACSGCGETPYVKLISQLFGDREMVANATGCSSIYSGSVPSTPYTMNEKGHGPAWANS
                     LFEDFCEFGLGMELANEKMRARLVKVMNEAIASDCCPAEYKEVFAEWINNMLDAEKTKE
                     LAEKIIPMVEAAKDKCNHCKQIADLQQYLVKRSQWIIGGDGASYDIGYGGLDHVIASGK
                     DVNILVLDTEVYSNTGGQSSKATPVGAIAKFAAAGKRVRKKDLGLMATTYGYVYVAQIA
                     MGADQAQTLKAIREAEAYPGPSLIIAYAPCINHGLKAGMGKSQEEEEKAVKCGYWHLWR
                     YNPALEEEGKNPFQLDSKEPNWEDFQGFLKGEVRYASVMKQYPAEAEELFKAAEENAKW
                     RYNSYKRLARENWGADTAE"
     CDS             complement(13538..14743)
                     /locus_tag="ctg51_10"
                     /transl_table=11
                     /translation="LPAEKQRNEMESFYRTHAYLVEHTNAPVRRDLMDEIDWSDRLIGI
                     KGTRGVGKTTFLLQYAKEKFGTDRSCLFINMNNFYFSGHSLVDFANEFQKRGGKVLLID
                     QVFKHPEWSKELRMCYDRFPSLKIVFTGSSVMRLKEENLELRDIAKSYNLRGFSFREFL
                     NLQTGMKFRAYSLEEILSTHEQIAKGVLSKVRPLDYFQDYLHHGFYPFFLEKRNFSENL
                     LKTMNMMVEVDILLIKQIELKYLSKIKKLLYLLAVDGPKAPNVSQLASDVQTSRATVMN
                     YIKYLADARLINLVYPKGEEFPKKPSKIMMHNSNLMYSIYPVKVEEQDVLDTFFVNTLW
                     KDHKVHKGDKNVSFMVDEVMPFKICAEGTKIKNNPDVTYALQKAEIGRGNQIPLWMFGF
                     LY"
     CDS             14923..16077
                     /locus_tag="ctg51_11"
                     /transl_table=11
                     /translation="MALASGETNYMAPASARQMASDLALLPMWYAEAGSAVLAPSAYNA
                     DFLKTKSELLGMDVALLTEPEVADGKDRKFSPWGWDPALRKRLMTLGADQTELPSADYM
                     NILREHSHRLQAVKLLPGLRLNEYFCGESFYLSTLAECSAFVEGREACLLKAPLSGSGK
                     GLNWCKGIFTTFISGWCARVAASQGGVVGEPIYNKVEDFAMEFYADGRGRVVFAGYSVF
                     HTGGSGMYAGNDLLSDEKILQKLSAYVPQEEFIRLRTRLEEELSALFGGFYHGYLGVDM
                     MICHFPDEAPVYRIHPCVEINLRMNMGVVAWLLTDRYLAADAEGVFRIDYYPLAGQALE
                     EHRQMSASFPLSVENNRVCAGYLPLVPVTPQSRYRAFLLLTLPQ"
ORIGIN
        1 gagagttgca gtctgattca gcctatagtc atttaagact agtgtcaaag ttagttcact
       61 gcaactctac ttttcaaata tacacttata ttttgttgtg atatttaata ctgcaaatgt
      121 aaatgtgtca aaagtcaaaa gtaactaaac tctcctcctt cctgaaggag gggaatttag
      181 ttgcttttga cacatcttct tttctgtttc ttatttcagt aaatgtcccc cttccctgtg
      241 ttttgattta ctacttaatc tgttaattat tagaatgata ataacagatg ttcttttttc
      301 taattgtccc cctctttctt gccttgtttt ataagccgat tgcctatctt tgcggcaggt
      361 ttttaaataa taaatcaaaa agagaaaact actttatgaa acacatttcg aacttcctca
      421 gatcaaaaag ctggaacgta tttttgtttt tatatcttgc tcttcctttg tttgcgcaaa
      481 aggaatataa gatcgatcag gtatctgttg ttaatgtagg cgatggcaga ctgttgtttc
      541 aggaactgaa aacggaaaaa gcattgaatg gcgaacatcg catcatagat ggttatcatt
      601 ccgcctatgt gctggcatct tttaaagatg gtttttatga tggcggatac aaagaatatg
      661 tggacaatat attaataacg gaaggaagtt ataaagaagg gcggaaggat ggcctcttca
      721 agattaactc caagtttgac ggtaagctga aagaagaaaa gtcctataag gaaggtaagc
      781 tggacggtac gagcaaaagt tactttacta ccggaaaagt ggaaagtgaa agaaacttcc
      841 ggatggggaa agagcacggg aagcaactgt cgtacgaatc tgacggtact ttgcggaaag
      901 agcataatta caaggacggg aagcaggtag gcaaacagta tacttttctg aaaggtacat
      961 atgatttgta tgagaccgtt tatttcaatg aagaaggttt tcaggacggt gaatattcgt
     1021 ccgtgtttac gtttggctcg ccacgtatac tgggtagtta taagaatgga aagaagaatg
     1081 gtcgttggac tacttttgct gaaagcggag atacgctgat gattgaaacc tatctggatg
     1141 gaaaagaaga tggactccat gtctcatttg ccaacggaag tggggtaagg cagaaagaat
     1201 attatatgaa gaacgatcgt aaagacggtt tataccgtga atataatttg gaaaatggtg
     1261 aattgagata tgaagctacc tatcaggccg gcagattgca tggcaaggaa cgacggctga
     1321 tagtgagcaa ccgctttgat tattgggaaa cttctaccta tgtgaacgga aggcagaacg
     1381 gaccgttcga agctcgttat gtaaagaatg accagcttcg tgaatgtggg gaatataaga
     1441 atggtcaccg tgtaggacga tggaaacgct acactattga tggtaaactg gaaaaggaat
     1501 gggatgaaaa ctaaccggta gatgaaaggt cagagcataa aaaaaggagc aacgccttgc
     1561 tccaaccttt gttaacctta aatctaatac tatgaaaaac acagtgcaaa gatacggact
     1621 tctgtgaaat ctgcaaatta tccaagtaaa acgctatgtt ttataacatt gattaagtgt
     1681 ttgttttacg ctttatactt ttgttaatac tttccgatgg tctgaaagag gactgctttc
     1741 cttcttttta gaataataaa tagctgaagt tagagaactt tacagtatta tttcttattt
     1801 ttgttcttaa ttggattaca gaaagaacta tgaaatgatg agatggatga agacgatgag
     1861 atatctgaag tggatgctgg tgctgtttgg tttaatcggg atgacggctt gccggcagga
     1921 tacaccccgt tttcgtattg gggtggctca atgcagcgat gattcatggc gacataagat
     1981 gaatgatgag attcttcggg aagcgatgtt ttataatggt gtttcggtgg aaatccgttc
     2041 ggcaggggat gataacagta agcaggcgga agatgtccat tattttatgg acgaaggagt
     2101 cgatctgctg attatttccg ctaacgaagc tgctcctatg actccgattg tagaagaagc
     2161 ttatcagaaa ggcatccccg ttattcttgt agaccggaag attctttcgg ataaatatac
     2221 tgcctatatc ggagccgata attatgaaat cggtcgttcg gtaggaaact atattgcctc
     2281 cagtctgaaa gggaagggaa atatagtaga actgacagga ttgagcggtt cgactcctgc
     2341 aatggaacgg catcagggat ttatggctgc catcagtaaa ttcccggata taaagctgat
     2401 tgataaagcg gatgctgcgt gggaacgtgg tccggcagag atagaaatgg atagtatgct
     2461 tcggaggcat cctaagattg atgctgtgta tgcccataat gaccgtatcg ctccgggtgc
     2521 ctatcaggca gcaaagatgg cagggcggga gaaggaaatg atttttgtcg gcatagatgc
     2581 cttgccgggt aagggaaacg gactggaact ggtactggac agtgtgctgg atgccacctt
     2641 tatctatccg accaatggcg ataaggtact gcaactggct atggacattc tggagaagaa
     2701 accctatccc aaagaaacgg tgatgaatac cgctgttgtg gaccgtacca acgcacacgt
     2761 catgcagttg cagaccacac acatttccga actcgacaaa aagattgaaa cgctcaacgg
     2821 acgtatcggt ggctatctct ctcaggtagc tacacaacag gtcgttttat acggcagtct
     2881 gattatcctt ttattggtag ccggcttatt attggtcgtt tataaatcac tccgctctaa
     2941 gaatcgcttg aataaagagc tttttaagca gaagcagcaa ttggaagagc agcgtgacaa
     3001 actggaagaa cagcgtgacc aattgataca gctctctcat caactggaag aagctaccca
     3061 tgccaagctg gtctttttca ccaatatttc tcacgacttc cgtactccgt tgacattggt
     3121 tgccgacccg gtagaacatt tgttggcgga caagacactg agcggagatc agcaccggat
     3181 gctcatgctg attcagcgga atgtgaacat tcttctgcgt ctggtcaatc agattctgga
     3241 tttccgtaaa tatgaaaacg gcaagatgga atatactccg gttacggtgg atgtcctttc
     3301 ttctttcgaa ggatggaatg agtcttttca ggcggcagcc cgtaagaagc atatccattt
     3361 ttcttttgat agtatgccgg atacggatta tcatacactg gcagacatgg agaagctgga
     3421 acgtatttat ttcaatcttc tgtccaatgc ctttaagttt acaccggaaa acgggaaaat
     3481 agccgtccgt ctgtcttccc ttagtaaaga ggacaagcga tggatacgtt tcacggtggc
     3541 aaataccggt tctatgattt ctgccgaaca tattcgcaat gtattcgacc gtttctataa
     3601 gatcgatatg caccataccg gttcgggaat cggactggca ttggtaaaag ccttcgtaga
     3661 aatgcacggt ggtatgatct ccgtagagag cgatgagaaa cagggcacgg tctttaccgt
     3721 tgaactgcct gtacagtctt gtgaggctgt tgctgccgaa ccggatacca cccttgtttc
     3781 tgcggattcc cgtacaacag atgttctatt ggcggaagag gaagaactgg aaaaaggata
     3841 tgactcttcc aaaccgtccg tactgattat tgatgataat gaggatatcc gttcgtatgt
     3901 ccatacgttg ttgcatacag actatacggt gattgaagcg gcagacggct ccgaaggaat
     3961 ccgtaaggct atgaagtatg ttccggacct gatcatttct gatgtgatga tgccgggcat
     4021 tgatggcatt gaatgttgcc gccggctgaa aagtgagtta cagacctgtc atattccggt
     4081 tattctgctg acagcgtgtt cactggacga acagcgtatt cagggatatg acggtggtgc
     4141 ggattcttat atttcaaagc cgttcagttc acagctgttg ctggcacgtg tccgcaatct
     4201 gatcgattct caccgtcgtc tgaaacagtt ctttggtgac gggcagacat tggcaaaaga
     4261 agatgtctgc gatatggaca aggattttgt agaaagattc aagtcattga ttgaagagaa
     4321 aatgggagac tccggtttga atgtggagga cttgggcaaa gacatgggac taagccgtgt
     4381 gcagctttat cgcaagatta aatcattgac taactactct ccgaatgaat tgctccgtat
     4441 cgcccgtttg aagaaggcag cttctttgct tgcttcttcg gacatgaccg tagcggagat
     4501 tggttatgaa gtcggtttca gttcaccttc ttatttcgcc aagtgctata aagagcagtt
     4561 tggagagagc ccgacagatt tcctgaaaag gaaaggatga tttcattgat atcgtaaaga
     4621 gggatatatg aaagattata aagtagataa agagagcttt tccgaatcct ttcggaagga
     4681 agtgtacgaa gtcgtatccc agatacctgt gggaaaagta tctacttatg gaggtattgc
     4741 tttgctgttg ggggcacccc aatgctcgcg gatggtggga cgtgcattga aagaagtgcc
     4801 ggatgaatta tccattccct gccatagagt tgtaaattcc accggaaggc tggtgcccgg
     4861 ttgggtggaa caaaaacaac tcttgctggc agaagaagtt tctttcaaag ctaacggatg
     4921 cgttaatctg aaagaacatt tgtggcacgt ggatgaatga aggatgcaag gaaggtaagc
     4981 catatcatcc gtatccatac aataaagaaa acccatacat gaagccataa ggtcctggta
     5041 atgaaatctc tgatgggtat agggacgaat atgtcgatag gaacgataca taacagcaca
     5101 aaacagcacc aaaatagaat cttgtctgtt gcggtacgtg ttggtctgct ccaataccag
     5161 agcatgaaac ctgccaatgc gataatatag gtatgcttct cggcggagtc actcagtaat
     5221 actacccagc ccatgagaat gcccaaagcc tgggcacgga aggcaaaaga cgaccatttg
     5281 cggaaattcc ccaaaaagag cagagtcagc aagccgagca ttcctatctg aagtgcacgg
     5341 aagtgtggca atgtccatgc tgcaatgggg cgggcataga aaaatgaatc ataagctccg
     5401 gcggactgat gaacagcaag actatggcac cattcttcat aataggggag caaatctgca
     5461 ggagctattt tgattaacgg taatgcaagc aatacaatgc ccattgtaac ggcatagcca
     5521 aagttacgcc atacgtgagg atagcacagc aacaatgcca gttcgaaaat tccatatact
     5581 ttggtacatc ccgaaatcat gattaacaga acagccagaa atccacggtc tttttccaat
     5641 aacgtatagg cgaataagaa taaataggct accgttatgt tatactgaaa tgaaagtaaa
     5701 ctttgtccta aaatcagtaa cagaaaaagg aacatacggc atttctgctg ctgggtgaat
     5761 tgttggggca gcgtgaagat cgccataaag aacagcgaat aattgaatag attccacgcg
     5821 aaaggtccca gccatgcagg cagatacgca aacggagcga acaataccgt gaaaactgga
     5881 gaataaagga agtagcgtcc gtgagcttct acaaattcag ttgtgtatgg gctgatgcct
     5941 tgccagaaga attgagtagc gtccgagaag accataaagt tttgatgccg tcctcgtata
     6001 aattcgagca gagtcactat aaaagcgagc aggaaaccta tcatgtagag attccgccgg
     6061 ctatagaaaa acggcatttt ggggttcttt ttactaagga actgtacttg gcttttgtcg
     6121 tctagtgtgg cagtacctgt ttgtttttct tttgttgtgt aatgacaatt atccttcccc
     6181 aggaaaattg taatagccct gttgaacata taaatctagt ttagttattg acgccaaata
     6241 tacggtgttt aagtgaaata ttcaaactta ttttatattt atctgccggt ttgttctatt
     6301 ttgctgagtg ataggggaat attacccgga aactttccat atcattacaa ataaagccct
     6361 ctgtatgccc cggattttga atataatttg tatgtttaat ccgttttttg tatctttgtg
     6421 ccagcaagat actggaacag gctgttttta tacataaaaa tgctattttt tgctattcgt
     6481 tgaaaggatt atcttatcaa attctattcc ttttttaatt actcagtctg tcaataatca
     6541 ttttattaat tatttcggga ttcattgtta tttgtccctt atttaaatca gaactttata
     6601 cgatataaag aaagattcct gttatcgttt gttcttgtct tgctgtgtat attattttaa
     6661 taacctaaac cattttattg tatgagtaaa atagaaatta aagatctcta tctggttttt
     6721 ggcaatgaga agcagaaggc tttgaagatg ttgaaagaag gtaaaacaaa aagtgaaata
     6781 ttgaaagcga ccggatgtac agttgcggtg aaagatgcga atctttccat taatgaaggc
     6841 gaaatattcg tcattatggg gctgtccggt agtggaaagt ccactttact ccgctgcatc
     6901 aaccgtttga tacgccctac ttccggagaa gtgattatca atggaacaga catagccaaa
     6961 gtgtcggata aggaactgtt gcagattcgc cggaaagaac tggctatggt ctttcagaac
     7021 ttcggtctgc ttcctcaccg ttctgtcttg cataatatag ctttcgggct cgaactacag
     7081 ggagtaaaaa agggagaacg ggagcagaaa gcgatggaaa gtatgcaact ggtggggctg
     7141 aaaggctacg agaatcagat ggtaagtgaa ctgtcgggtg ggatgcagca gcgtgtcggg
     7201 ctggcgcggg ctttggccaa taatcccgaa gtcctgttga tggatgaggc cttctcggca
     7261 ctcgatcctt tgatccgtgt gcagatgcag gatgaactgc tgactttgca gtcgaagatg
     7321 aaaaaaacga ttgtctttat tactcacgac ctgagtgaag cgattaaatt gggtgaccgg
     7381 attgctatca tgaaggatgg agaaattgta caaatcggta catcggaaga aatcctgacc
     7441 gaacctgcca acgcttatgt agaacgattt gtggagaatg tagatcgaag caagattata
     7501 acagcttcct ctgttatggt agataaaccc atagtggcac gtttgaagaa agaaggcccg
     7561 gaggtgctga tccgtaagat gcgcgaacgg aatctgaccg ttcttccggt agtcgattcc
     7621 aataatctgt tagtaggaga ggtgcggttg aatgacttgc tgaaactacg aaaagagcaa
     7681 atccgctcca tcgagtccgt agtaaggcat gaagttcatt cagtgctggg tgatacggtg
     7741 ctggaagata ttcttccgtt gatgacaaaa acgaactcgc caatctgggt cgtaaatgag
     7801 aatcgggagt ttgaaggcgt agtgccactt tcctcattga tcatcgaagt aacgggaaaa
     7861 gataaagaag aaattaatga aatcattcaa aacgcaatag aattatgata aatatcggac
     7921 aatatataga gactgccatt aattggctca cagaacattt tgcttccttt tttgatgctc
     7981 tcagcatggg gatcggagga ttcatagacg gttttcagca cgtactgttt ggaatacctt
     8041 tttatatcac aattgcagtg ctggctgcgc tcgcctggtt taagtcgggt aaggggacag
     8101 ccgtatttac cctcttgggt ttattgctta tttacggcat gggcttttgg gaagaaacga
     8161 tgcagacatt ggcattggta ctttcttcca cttgtctggc attgctttta ggcgttccgt
     8221 tgggaatctg gactgccaac agtgatcgtt gtaacaagat aatgcgccct gtcctcgact
     8281 ttatgcagac aatgcctgcc tttgtctatc tgattcctgc cgttctattc ttcggattgg
     8341 gaactgtgcc gggagctttt gccaccatca tctttgcaat gcctcctgtg gttcgtctga
     8401 ccggtctggg cattcgtcag gttcctaaaa acgtagtaga agcctcccgc tcttttggag
     8461 ctactccctg gcagcttctt tataaggtgc aattgccttt ggcgttgcct actattctga
     8521 cgggaatcaa ccagacgatc atgatgtcac tttcgatggt agtgattgct gccatgattt
     8581 ctgccggagg attgggagaa atcgtgctga aaggtatcac ccaaatgaaa atcggactcg
     8641 gatttgaagg cggtatcgca gtcgtgatat tggcgatcgt gctggaccgc atcactcagg
     8701 gtatggcaga taacagaaaa agtaaaaaga aataagaatc acaccaaaga aaggaataat
     8761 caatgaataa gataaaaatg attgcggcaa tgtttattgc cggcatactc ttaaccttcg
     8821 tttcctgcgg agacaacgga aagagtaaga agataagtat cgcttatgcc aactggtcgg
     8881 aaggtattgc aatgacaaac cttgccaaag cgatttttga agatcagggg tacgatgtaa
     8941 agttgctgaa tgccgacctt gcacctatat ttacctctat ctcccgtaag aaagcagacg
     9001 tatttatgga tgtctggatg cctgtcacta tggaagatta tatgaaacaa tacggggata
     9061 aactcgaagt tatcggggat atttatgatg gtgcccgtat cgggctggtg gttccggatt
     9121 acgttacgat caactcaatc gaagaactga acgcggaaaa ggaacgtttc tccggtcaga
     9181 ttgtcggtat tgatgccgga gccggtatta tgaaagctac cgatcaggcc atcaaagact
     9241 atggattgga ttataaactg atgacttcga gcggacctgc catgactgct tccctaaaga
     9301 aagcgattga taagaaagac tggattgtcg tgacgggatg gacgcctcac tggatgttcg
     9361 accgtttcaa gctgaaagtt cttcaggacc cgaagctgat atatggaaat acggaatcca
     9421 ttcataccat agcatggaaa ggttttagcg agaaagaccc ttttgctgcc gaacttttgg
     9481 gcaacattcg tctgacagat gcggaaatca gctccttaat gactgctctg gaagaggcgc
     9541 agacaacgga aagacaggct gcccgtcaat ggatggaaga acatcaggaa ctggtgaaca
     9601 gttggattcc tgagaaagat tgatatgcaa acactacttc aaccatcccg ccattctttc
     9661 tttaccatag aagtagtaga aaagtagtcc cagccagctg gtaagaacga ttaatacaat
     9721 cgctataagt cttttctcta cagccgcatt tatattccaa atctctatgg cagctctgaa
     9781 agtcagtatc aaaccgataa tccaaataac aaatccgatc atatctttag agttttaatg
     9841 aatatcttcg tgagaagtaa tcgttacttc taagatataa acaaaaaagg caggaatctg
     9901 tttccaggat tcctgccttt tattatgtac aaagtatttc tacttattat tcagctgtat
     9961 cagctcccca gttttctctg gcaagacgtt tgtagctgtt gtaacgccat ttagcgtttt
    10021 cttcagcagc tttaaacagt tcttcagctt cagcaggata ttgtttcatt acagaagcgt
    10081 aacgaacttc acccttcaag aaaccttgga agtcttccca gttaggttct ttgctatcca
    10141 gttggaacgg attcttgcct tcttcttcca aagcagggtt gtaacgccac aagtgccagt
    10201 aaccgcactt aacagccttt tcttcttctt cctggctctt acccataccg gctttcagac
    10261 cgtggttgat acatggagcg taagcgatga tcagtgatgg tcccggatat gcttcagctt
    10321 cacggatagc tttcagagtc tgagcctggt cagcacccat agcaatctga gcaacatata
    10381 cataaccgta agtagtagcc atcagaccga ggtctttctt acgtacacgc ttacctgcag
    10441 cagcaaactt agcgatagcg cctaccggag tagctttaga agactgacca cctgtgttag
    10501 agtaaacctc agtatccaat acaaggatgt taacgtcctt accggaagcg attacatggt
    10561 caagaccacc gtaaccgata tcataagaag caccgtcacc accgatgatc cattggctgc
    10621 gtttaacaag atattgttgc agatcagcga tttgcttgca gtggttgcat ttatctttag
    10681 cagcttctac catcggaatg atcttttcgg ccagttcctt agtcttttct gcatccagca
    10741 tattgttgat ccattcagca aatacttctt tgtattcagc cgggcagcaa tcagaagcga
    10801 tagcttcgtt cattactttc accagacggg cacgcatctt ttcgttagcc agttccatac
    10861 ccagaccaaa ttcacagaag tcttcgaaca aggagttagc ccatgcagga ccgtgaccct
    10921 tttcgttcat agtgtacgga gtagaaggaa ctgaaccgga gtagatagaa gaacatcctg
    10981 tagcgttagc aaccatttca cggtcaccga acaactgaga aatcagtttc acgtacggag
    11041 tttcaccaca accggagcaa gcgcctgaga actcaaacaa cggagttgcg aactgagagt
    11101 tcttcacgtt agccttgatg tctaccaggt gttgtttgct cttcacgttt tcagcgcagt
    11161 aagtccagtt atcagcttcg gccaactggc tttcaaggtg tttcatggtc aatgccttgc
    11221 cacccttctt cggattaccc ggacagatgt cggcacagtt accgcaaccc agacaatcga
    11281 gaacgtctac ctgaatacgg aatgtcatac catcgaatgc tttacctaca gctttcagtt
    11341 gctcgaactt agcacccttc tgctcttcag catcgagtac gaacggacgg atagaagcgt
    11401 gaggacaaac gtaagcacac ttgttacact gaatacagtt ttcagcattc cattcgggaa
    11461 cgaatgcagc tacaccacgt ttttcgtatt tggaagtacc ttgataccaa gtaccgtctt
    11521 cgataccctt gaatgcagat accggcagca agtcaccgtc ctgtgcattg atcggacgaa
    11581 ctacttcgtt gatgaaagca ggatcattgt tttctgcttt tgcatcatcc ggcaggttag
    11641 cccaagcagg atcgacagtc agagtcttgt attcaccacc gcggtctaca gcagcgtagt
    11701 tcttgttaac aacgtcttca cccttcttgc cgtaagactt aacgatgaat ttcttcatct
    11761 gttcaacagc ttgatctaca gggattacgc ctgtgatacg gaagaatgca gactgaagga
    11821 ttgtattggt acggttgccc aaaccaattt ccattgcaat ctgagttgcg ttgatatagt
    11881 atacagagat gttgttctgt gcaaagtatt tcttcacctt gttaggcagg ttcttagcca
    11941 gttcttcgcc ttcccagatg gtattcagca agaaagaacc gttcttacgc aaaccacgtg
    12001 ttacgtcgta catgtgcagg taagcctgaa cgtgacaagc aacgaagttc ggagtattta
    12061 ccaagtaagt agaacggatc ggagtatcac cgaaacgcaa gtgagaacaa gtgaaaccac
    12121 ccgacttctt ggagtcgtaa gagaagtaag cctgacagtg tttgtcggtg ttgtcaccga
    12181 taatcttaac agagttcttg ttggcaccta cagtaccgtc agcacccaga ccgtagaatt
    12241 tagcttcgaa cataccttca ccgcccagag cgatttcttc tttctgagga agagaagtga
    12301 acgtaacgtc gtctacgata ccgatagtga agtggttctt cggcattggc atagccaagt
    12361 tttcgaatac agagatgatc tgtgccggag ttgtatcttt tgaacccaga ccgtagcgac
    12421 cgccaacgat aacaggagca ttttctgcgc catagaagca gtctttaacg tcaaggtaaa
    12481 gaggttcgcc gttagcaccc ggttcttttg tacggtcaag cactgcgatg ctctttgcag
    12541 tcttgggtac agcagccagg aagtgtttag cagagaacgg acgatacaag tgtacggcaa
    12601 ccatacctac tttttcgccg tttgctacca agtggtcgat agcttcgcgg gcagcttcag
    12661 ttacagaacc cattgcgata attacgcgtt ctgcatcttc tgcaccgtag taatcgaaca
    12721 aaccgtattt gcggcctgtg atcttggaaa tttcgttcat gtattcttct acgatagcag
    12781 gaactgcttc atagtagtta ttgcatgatt cacgatgttg gaagaagtgg tcggggtttt
    12841 cagccatacc acgggcaacc ggcttcatcg gattcagtgc acgggcacgg aattcagcca
    12901 aagcttcctg gtcgatcagc ggagcgaggt cgtcgttttc caacatttcg atcttctgga
    12961 tttcgtgaga agtacggaaa ccatcgaaga agttcatgaa cggaacgcgt gatttgatag
    13021 tagccagatg agcaacacct gccaaatcca taacttcctg tacagaacct tctgccaaca
    13081 tagcgaagcc ggtttgacga gctgacatta cgtcctgatg gtcaccgaag atacacaatg
    13141 cgtgagaagc cagtgtacga gcagaaacgt ggaatacaca aggcaagaat tcaccggcaa
    13201 tcttgtacat gttagggatc atcaaaagaa gaccctgaga agcagtgtaa gtagtagtca
    13261 atgcaccagc ctgaagagaa ccgtgaactg caccggcagc accaccttca gattgcattt
    13321 cctgtaccaa tactgtttcg ccgaagatgt tcttacgtcc tgcggcagcc cattcgtcta
    13381 cgtactcagc catagtcgaa gaaggagtga tggggtagat agctgctact tcagagaaca
    13441 tatacgagat atgtgctgca gcttggttac catcacatgt gatgaatttc ttctgtttag
    13501 tcataactaa attaaatatt taagtaaata aatcttttta gtataagaat ccgaacatcc
    13561 aaagaggtat ttggttgccg cggcctatct cagccttttg caacgcatac gtcacgtccg
    13621 ggttattctt tatttttgta ccttccgcac aaattttgaa cggcatcact tcgtctacca
    13681 tgaaagagac gtttttatct cctttatgta ccttatggtc tttccataaa gtgttaacga
    13741 agaacgtgtc gagtacatcc tgttcttcca ctttcaccgg ataaatggag tacatcaggt
    13801 tagagttgtg catcataatc tttgacggtt tctttgggaa ttcttctcct ttcgggtaaa
    13861 ccagattaat cagacgcgcg tctgccagat acttgatata gttcattacc gtagcgcggg
    13921 atgtctgtac gtcacttgcc agttggctca cgttcggagc tttcggtccg tccacagcca
    13981 acaaatatag taattttttt atctttgaaa gatatttcag ctcaatttgt ttgatcagca
    14041 agatatccac ttctaccatc atgttcattg ttttcagcag attctccgag aaattacgtt
    14101 tttcaaggaa gaaagggtag aaaccatgat gcaggtaatc ctgaaaataa tccagcggtc
    14161 gtactttgga aagtactcct ttggctatct gttcatgtgt actgaggatt tcttcgaggc
    14221 tgtatgcccg gaatttcatt cctgtctgca ggttcagaaa ttcacggaaa gagaatccgc
    14281 gcaggttata acttttcgca atgtcacgca attcgaggtt ttcctctttg agtcgcatga
    14341 cggaagaacc ggtgaagaca atcttcaggc tggggaaacg gtcatagcac attcgtagct
    14401 ctttgctcca ttcgggatgt ttgaacacct ggtcgatcag cagtactttt ccgccacgtt
    14461 tctgaaactc gttggcgaag tcaacaaggc tgtgaccgga gaaataaaag ttgttcatat
    14521 tgatgaacag acaggaacgg tcggtgccga atttctcttt ggcgtactgc aggaggaaag
    14581 tggtttttcc tacgccacgt gtccctttga taccaatcag acggtcactc cagtcgatct
    14641 cgtccataag atcgcggcga acgggggcat tggtgtgctc aacgaggtag gcgtgtgtgc
    14701 gatagaatga ttccatttcg tttctttgtt tttcggctgg caaatatagt gcttttttta
    14761 ggatttgcaa agtagagata gcaaaaatgt gctttaattt ataagtttct ctttattgtg
    14821 taagttcctg attatttcct gtatatattt gcagaataat gtgttgaatc catctttgac
    14881 atgacgaaaa gacctgttta tatattcaat ccggagcatg atatggcgtt ggcaagcggt
    14941 gagacgaact atatggcgcc ggcttccgcc cgacagatgg cgagtgacct ggcgttgctt
    15001 cctatgtggt atgccgaagc gggaagtgcg gtgcttgcac cgtctgctta taatgcggac
    15061 ttcctgaaaa caaagagtga acttttgggc atggatgtgg ccttgttgac ggaaccggaa
    15121 gtggctgacg gtaaagaccg gaagttctct ccgtgggggt gggaccctgc tttgcggaag
    15181 cgtttgatga cattgggggc agatcagacg gagctgcctt ctgcggatta tatgaatatt
    15241 ctgagagagc attcgcatcg tctgcaggcg gtaaagttgt tgcctgggtt gcggttgaat
    15301 gaatacttct gtggagaatc tttttatttg agtactttgg cggagtgcag tgcgttcgtc
    15361 gaagggcggg aagcgtgctt gttaaaagct ccgctttccg gaagcgggaa aggattgaat
    15421 tggtgtaaag gcatatttac tacttttatt tccggttggt gtgcccgtgt cgctgcttct
    15481 cagggtgggg tggtaggcga acctatatat aataaggtgg aagatttcgc tatggagttt
    15541 tatgctgacg ggagaggaag ggttgttttt gccggatatt cggtcttcca cacgggtggg
    15601 agtgggatgt atgcagggaa tgacttgctg tctgacgaga agattctgca gaaactatcg
    15661 gcttatgtgc cacaagaaga atttatcagg ctgcggactc gtttggaaga agaattgtca
    15721 gctttgttcg gtggctttta tcatggatac ttgggagtgg atatgatgat ttgtcatttt
    15781 ccggatgaag cgcctgttta ccggattcat ccttgtgtcg aaattaatct gcgaatgaat
    15841 atgggggtgg tggcatggct cttgacggat cgttatttgg ctgcggatgc ggaaggagtt
    15901 tttcggattg attattatcc tttagccggt caggctttgg aggaacatcg gcagatgtcg
    15961 gcttcgttcc ctttgtccgt agagaataat cgggtgtgtg ccggatattt gccgttagta
    16021 ccggtgacgc ctcaaagccg gtatcgtgcg tttcttttgc ttactctccc ccagtgaaaa
    16081 agatagtgct tttgctctca tgctctaaca gttcgtctgt atccctttat tcatcgatgt
    16141 tttagctgtt agagatccag tggtagcaga gtgagagcaa ggacttgctc tcactctgca
    16201 tcgtcctgat aaataccgtt tttactgtgt tattctttga tttacaggat gttaatatct
    16261 gatatctcaa ctgttaacgt ttgatttctc agatattaat aattgagaaa tcaagtatta
    16321 aggactgata atttatgtat tattgactga tatatgattt aatgttttca gagagagcag
    16381 tactattgaa gtagctgatg cgttcaatgt gattggaaca tgcggttaag tcaatcaaat
    16441 caacagtagt ttcagatagt ttcgagcgtt tggaactaaa gtttcaagcg tatgaaactc
    16501 tagtttctca ccgatgaaac tacagtttca caccgatgaa actctggttt caagcaatgg
    16561 aaactctttg aagatactgc taaattggaa ttggtgaaca tcggaaaagt catattgtgg
    16621 taatactgtg tacttcccta ataatggttg acttgtttat ctctaatagc tgctatgtgt
    16681 tgactagaaa tattactaac cctggcagct gtttacttta ttatttatta ttcctgcctc
    16741 cggtttactt attt
//
