LOCUS       gnlProkkaHMELDMJP_306  15200 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|HMELDMJP_306.
ACCESSION   gnlProkkaHMELDMJP_306
VERSION     gnlProkkaHMELDMJP_306
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2024-11-17 03:46:49
            Original ID  :: gnl|Prokka|HMELDMJP_306
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 10809
            Orig. end    :: 26009
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..15200
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="True"
                     /core_location="[10000:10231]"
                     /cutoff="10000"
                     /detection_rule="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /neighbourhood="10000"
                     /product="RRE-containing"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..10231
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /neighbourhood="10000"
                     /product="RRE-containing"
                     /protocluster_number="1"
     cand_cluster    1..15200
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /kind="single"
                     /product="RRE-containing"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..15200
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="RRE-containing"
                     /region_number="1"
                     /rules="minimum(1, [Bottromycin_Methyltransferase_RRE,
                     Cyanobactin_D_RRE, Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /tool="antismash"
     CDS             complement(334..999)
                     /locus_tag="ctg306_9"
                     /transl_table=11
                     /translation="MFEIKVSKEIKDACPVFAGAAVYAVVKNTAYSEGLWQEIDAFTKQ
                     LTSTTQMEDIKHQPVIFATREAYKRCGKDPGRYRPSAEALRRRLMRGIPLYQIDTLVDL
                     INLVSLRTGHSIGGFDADKIQGTHLELGIGKAGEPFEGIGRGVLNIEGLPVYRDSFGGI
                     GTPTSDHERTKMDLETTHILAIVNGYNGKEGLQEAVEMIQTLLRNYTESDGGEIVFFE"
     CDS             complement(1050..1862)
                     /locus_tag="ctg306_10"
                     /transl_table=11
                     /translation="MISLTKHNELKGYKSLEAYPEVAHFVTTRHEGISTGAYGSFNCSP
                     YTNDSCMNVNRNQSWLFQCMNHQIKELFIPEQSHGCASLIINESFFKESLEMRRLLLRG
                     MDALITNVPGYCVCVTTADCVPVLLYDKKQHVVAAVHAGWKGTVKHIVSHVMDHLNKMF
                     GTQGEDVIACIGPSISLESFEVGDEVYDAFEESGFDMSLISMKKKETGKYHIDLWEANR
                     IELLNLGVPAEQIEVAGICTYIHHDEFFSARRLGIDSGRTLSGIMIRK"
     CDS             complement(1859..2947)
                     /locus_tag="ctg306_11"
                     /transl_table=11
                     /translation="MRREKYCPNGGPDGGDGGRGGHIILRGNRNYWTLLHLKYDRHAMA
                     GHGESGSKGRSFGKDGADKIIEVPCGTVVYNAETGEYLCDVTEDGQEVVLLKGGRGGQG
                     NWHFKTATRQAPRFAQPGEPMQEMTVIMELKLLADVGLVGFPNAGKSTLLSSISAAKPK
                     IADYPFTTLEPNLGIVSYHGGKSFVMADIPGIIEGASQGKGLGLRFLRHIERNSLLLFM
                     VPADSDDIRKEYEVLLNELRTFNPEMLDKQRVLAVTKSDMLDQELMDEIEPTLPEGIPH
                     VFISSVSGLGISVLKDILWEELNKESNKIEDIVHRPKDVTRLQQELKDMGEDEDIVYEY
                     EEDVDDDDDIDYEYEEEDWEEK"
     CDS             complement(3112..3681)
                     /locus_tag="ctg306_12"
                     /transl_table=11
                     /translation="MLNIVIFGAPGSGKGTQSERIVEKYGINHISTGDVLRAEIKNGTE
                     LGKTAKGYIDQGQLIPDELMIDILASVFDSFKDSKGVIFDGFPRTIAQAEALKKMLAER
                     GQDVSVMVDLDVPEEELMVRLIKRGKDSGRADDNEETIKKRLHVYHSQTAPLIDWYKNE
                     KKYQHINGLGTMEGIFAEICEAVDKL"
     CDS             complement(3741..4277)
                     /locus_tag="ctg306_13"
                     /transl_table=11
                     /translation="MDTIQIKDKLFTVSIKEQEIQKEVIRVANEINRDLAGKNPLFLSV
                     LNGSFMFTADLLKHITIPCEISFVKLASYQGITSTGVIKEVIGLNEDIAGRTIVIVEDI
                     VDTGLTMQRLLETLGTRNPEAIHIASLLVKPEKLKVNLNIEYVAMEIPNDFIVGYGLDY
                     DGFGRNYPDIYTVVD"
     CDS             complement(4318..5862)
                     /gene_functions="transport (smcogs) SMCOG1202:major
                     facilitator transporter (Score: 46.8; E-value: 2.5e-14)"
                     /gene_kind="transport"
                     /locus_tag="ctg306_14"
                     /transl_table=11
                     /translation="MSALKGHPKGLYLIFATSTAERFSYYGMRAIFILFLTQALLFDKE
                     AAASIYGSYTGLVYLTPLIGGYIADKYWGIRRSVFWGAVMMAVGQFLMFMSASTLDNTN
                     LAHWMMYGGLGFLILGNGCFKPTVSSLVGQLYEPGDRRLDAAYTIFYMGVNVGSFAAPL
                     ICGYLGDTGDPHDFKWGFLAAGIMTLFTVVLFETQKNKYLFSPSGEPIGIIPDAKREKK
                     EDKADHISHPKMDKRTKVRNTLVITILTIALIAFFNYAFEGDWVSIGIFTACIVFPVLI
                     LLDGSLTKIERSRIFVIYIVAFFVIFFWAAYEQAGASLTLFASEQTNRDIFGWEMPASW
                     FQSFNPLFVVVLAYIMPGVWGFLNKRKMEPASPTKQAIGLLLLSLGYLFICFGVKDAVP
                     GVKVSMIWLTGLYFIHTMGEIALSPIGLSMVNKLSPLRFASLMMGIWYLSTATANKFAG
                     MLSGLYPEAGKVKSIFGYQIATMYDFFMVFVVMSGVASLILFLLSKKLQKMMHGVE"
     CDS             complement(6057..6281)
                     /locus_tag="ctg306_15"
                     /transl_table=11
                     /translation="MMEKTKIGLNAGKVWRILNEKGELSMFDLCRELSLTFEDVALAIG
                     WLAREDKIFLRKREGMLFASIENVEFTFG"
     CDS             7211..8521
                     /locus_tag="ctg306_16"
                     /transl_table=11
                     /translation="MMAEKGYKIEVFLFNTKGELSPDCQTNKELVEMMEEVKFHEISTQ
                     FVPPVLTPDHLVIDGLFGSGLNKPLSGGFAAVVKYINSSPAMVVAIDIPSGLMGEENTF
                     NVKANIIRADVTFSLQLPKLAFLFAENTEFVGEWELLDIQLSEDGIEEMETNYEMLEIE
                     QIRSLIKPRKQFAHKGNFGHALLIAGSKGMAGASVLAARACLRSGVGLLTVHAPMCNND
                     ILQTSIPEAIVETDINETCFAVPTDTDDYQAVGIGPGLGRNEETEAALLEQLEHCQTPV
                     VVDADALNILANHRHALTHLPKGSILTPHPKELERLTGKCQDSYERLMKACELARAAHV
                     HIILKGAYSAIITPEGKCFFNPTGNPGMATGGSGDVLTGVILALLAQGYPTEEAAKIGT
                     YIHGLAGDVAQKKQGMIGMIASDIITCLPTAWRLVSE"
     CDS             8594..9661
                     /locus_tag="ctg306_17"
                     /transl_table=11
                     /translation="MKKLIIAAGLLMTTSAYAQTEVLTGVTRGKDYGVVYSLPKTQIEL
                     EIKANKVNYTPGEFSKYADRYLRLTNVSADPEEYWELASVKVKSVGVPNSETTYFVKLK
                     DKTVAPLMELTEDGIVKTINVPYSNSSVSKKVAPAPAVLQKKANPREFLTEEILMASST
                     AKMAELVAKEIYNIRESKNALLRGQADNMPSDGAQLKIMLDNLNAQEEAMTQMFSGTCN
                     KEERTFTVRLTPDKEFNNEVAFRFSKKLGVVANNDLAGTPFYISLKDLKSVKIPQEDDK
                     KKKDLDGIAYNVPGQAMVTLTDGKKKLYEGELPITQFGVIEYLAPVLFNKNSTIKVYFD
                     PNTGGLLKVDREEGK"
     CDS             complement(10001..10231)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RRE-containing: PqqD_RRE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF05402"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg306_18"
                     /sec_met_domain="PqqD_RRE (E-value: 7.2e-12, bitscore:
                     35.7, seeds: 9, tool: rule-based-clusters)"
                     /sec_met_domain="PF05402 (E-value: 4.2e-18, bitscore: 56.2,
                     seeds: 461, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MQRFLVPKGMSKELHVKLEEHGTAVWELIDGKRNVREIIEKLADH
                     FQNEEGYESRVSAYLSQMQKDGFIKLVIPVV"
     CDS             complement(10449..11759)
                     /gene_functions="transport (smcogs) SMCOG1106:major
                     facilitator transporter (Score: 85.2; E-value: 5.8e-26)"
                     /gene_kind="transport"
                     /locus_tag="ctg306_19"
                     /transl_table=11
                     /translation="MLCGYFLTDVMSPLKPMLEKELLWDSLDYGFFTSAYGWFNVFLLM
                     LIFGGIILDKMGVRFTGMGACLLMVFGCGLKYYAISTTFPEGAMLFGFKTQVTLAALGY
                     AIFGVGVEIAGITVSKIIVKWFKGKEMALAMGLEMATARIGTTLAMVLTVPLADFFGST
                     DESGTFHTNIPAPILFCLIMLCVGTIAFFLYTFYDKKLDASLDAEGLEPEEPFRMKDIV
                     YIITNKGFWLIALLCVLFYSAVFPFIKYAADLMVQKYNVDPKLAGTIPGLLPIGAIILT
                     PLFGSLYDRIGKGATLMIIGSVMLIFVHTMFALPILNIWWFATIIMIILGFAFSLVPSA
                     MWPSVPKIIPEKQLGTAYALIFWVQNWGLMGVPLLIGWVLNTYCKGPVVDGAQTYDYTL
                     PMTIFALFGVLALIVALMLKAENKKKGYGLEEANIQK"
     CDS             complement(12087..12458)
                     /locus_tag="ctg306_20"
                     /transl_table=11
                     /translation="MVIAALLMCFIVLIQNSKGGGLASGFSSSNAIMGVRKTTDFLEKA
                     TWGLAIFMVVMSIATAYVVPRSAVAKDAVLEQAQKEQQTNPYNLPAGTAAPQTEAPATN
                     APATETPAPAAETPAPAAE"
     CDS             complement(12489..13262)
                     /locus_tag="ctg306_21"
                     /transl_table=11
                     /translation="MTSVNFQQWIQHPETLNRDTLYELRNLLARYPYFQSLRLLYLKNL
                     YILHDISFGGELRKAVLYIADRRQLFRLIEGDRYDVQARKKGVPLTEVLKDEPSVDRTL
                     ALIDAFLSTVPEEVTARTSFDYSMDYTSYLLEETPATEQSSEETPKLKGYELIDDFIEK
                     SESDSPLCMKPLREEMPSSPTSSDEPTEEETMKEEEEDDSCFTETLAKIYVKQQRYSKA
                     LEIIKKLSLKYPKKNAYFADQIRFLEKLIINANSK"
     CDS             complement(13268..13795)
                     /locus_tag="ctg306_22"
                     /transl_table=11
                     /translation="MNWIKKIIRPLLLFGLPLVVIACTVSYKFNGSSINYDKVKTISIA
                     DFPIKSEYVYAPLATKFNEDLKDIFIRQTRLQLLKPNQNADLQIDGEITGYNQYNQAVS
                     ADGYSSETKLTITVNVRFVNNTNHAEDFEQQFSAFRTYDSSQLLTAVQDGLIAEMSKEI
                     TDQIFNATVANW"
     CDS             complement(13782..15023)
                     /gene_functions="regulatory (smcogs) SMCOG1112:sigma-54
                     dependent trancsriptional regulator (Score: 390.2; E-value:
                     2.3e-118)"
                     /gene_kind="regulatory"
                     /locus_tag="ctg306_23"
                     /transl_table=11
                     /translation="MTKAEIQQVKQRFGIIGNTEALSRAIDVAIQVAPTDLSVLITGES
                     GVGKESFPQIIHQYSRRKHGQYIAVNCGAIPEGTIDSELFGHEKGAFTGAIGERKGYFG
                     EADGGTIFLDEVGELPMSTQARLLRVLESGEFMKVGSSKVQKTDVRVVAATNVNLTQAI
                     AEGRFREDLYYRLNTVPIQIPPLRERGDDVLLLFRKFSADFAEKYRMPAIQLTEDAKKE
                     LLAYPWPGNVRQLKNITEQISIIETNREISAAILQNYLPAQNTQRLPALMGTRESKGFE
                     SEREILYSVLFDMRQEVAELKKMVHNLMAERAGQVGQVGQMGTVVTTPVVTAHQPSVPA
                     IIHTMQPTVCKDDDDIQDTEEYVEESPLSLDEVEKEMIRKALERHHGKRKSAAKDLNIS
                     ERTLYRKIKEYELD"
     CDS             complement(15033..15200)
                     /locus_tag="ctg306_24"
                     /transl_table=11
                     /translation="MVACEDSFRQAIYVAIDVFRNRQREKVARANPLRKQYYEKRDDSD
                     KLKLDTVDED"
ORIGIN
        1 gacatacgca ccactccatc aaaagcagca cgaatcgtat cttttgcaca ggtcttaatg
       61 tctgttcctg aatgtcctcc gcgagttcca taggcagaga ttacttttcc tccgggtaat
      121 gggaaagcat attcgtgatc tttcagagaa tccaaatgca gatagatatg attgctttta
      181 gcaaataatc cgggagtagc tacccgtaca tcagccattt cgcgggcaga gaaggaggat
      241 ttatcctgcc cggcggcagt cagtggcaat aataaaactg tcagtaagat aagtatgttt
      301 ttcatgtctt ttttcttaga gcactcattc taattattcg aagaatacga tttcgcctcc
      361 atccgattct gtatagtttc ttaataaggt ctgtatcatt tcaacagctt cttgcaaacc
      421 ttcttttccg ttataaccgt tgactatggc taggatatga gtagtttcga ggtccatctt
      481 cgtacgttca tggtcgcttg tcggggttcc gattccgccg aaagaatcac gatatacagg
      541 taatccttcg atattcaata ccccgcgtcc gataccttca aacggttctc ctgctttgcc
      601 gataccgagt tcaagatgcg taccttgtat tttgtccgcg tcaaaaccac cgatcgaatg
      661 tcccgtacga agagacacaa ggttgataag gtctaccaac gtatcaatct gatataaagg
      721 aattccacgc atcaggcggc ggcgtagagc ttcggctgac gggcggtaac gtccggggtc
      781 tttgccacaa cgtttataag cctcacgggt agcaaagata acgggttgat gtttgatgtc
      841 ttccatctgt gttgtggaag tcagttgctt ggtaaaagcg tcgatttcct gccaaagccc
      901 ttcgctgtaa gctgtatttt tcacaacagc atacacagcg gctccggcaa aaaccggaca
      961 tgcgtctttt atttctttag atacttttat ttcaaacata acttatcata aaccaatcat
     1021 cagcgtcctg caataacgga caccaattat tactttctaa tcattattcc cgacaatgta
     1081 cgaccggaat ctattcccag tctacgcgcg gagaagaatt catcatgatg aatataggta
     1141 cagattccgg ccacttctat ctgttctgca ggcactccga gattcagtaa ttcaatccgg
     1201 ttggcttccc acaaatcaat atgatatttg cctgtctcct tcttcttcat agaaataaga
     1261 gacatatcga agccgctttc ttcaaaagca tcatacacct catcacctac ttcaaatgat
     1321 tcgagcgaaa tgctcggccc gatgcaagct atcacatctt caccttgcgt cccgaacatc
     1381 ttattcaagt gatccatcac atgactgaca atatgcttca ccgttccttt ccatccagca
     1441 tgaacggcag ccacaacgtg ttgttttttg tcgtacagca atacaggaac acaatccgcc
     1501 gtcgtgacac aaacgcaata tcccggcaca ttagttatca aggcatccat tcctcgcaga
     1561 agtagccgtc tcatttccaa tgattcttta aaaaatgatt cattgataat cagactggca
     1621 caaccatgac tctgttcagg aataaataat tcttttatct gatgattcat gcactgaaac
     1681 aaccagctct gattgcgatt gacgttcata catgagtcgt tggtataagg cgaacagttg
     1741 aaagagccgt aagctccggt gcttatacct tcgtgacgcg tagttacaaa atgagctact
     1801 tcgggatatg cctccagtga cttatacccc ttcaactcgt tatgttttgt aagtgaaatc
     1861 atttttcttc ccaatcttct tcttcgtatt cataatcgat atcatcgtca tcgtcgacat
     1921 cttcctcata ttcataaacg atgtcttcat cttcgcccat gtctttgagt tcctgttgca
     1981 gacgggtcac gtctttcgga cggtgaacga tgtcctctat cttattgctt tccttgttca
     2041 gttcttccca aaggatgtct ttcaacaccg agatacccaa accggaaaca gaagatatga
     2101 atacatgtgg aatgccttcc ggcaatgtag gttcaatctc gtccatcaac tcctgatcga
     2161 gcatatcact tttggtgaca gccaacacac gttgcttgtc caacatttca ggattgaagg
     2221 tacgcagttc gttcagcaag acttcgtatt ctttacgaat gtcgtcgctg tctgccggaa
     2281 ccataaacag cagtaatgaa ttacgctcga tatgacgcaa gaaacgcagt cccaaacctt
     2341 ttccctgact agcaccttcg ataatacctg gtatgtccgc catcacaaag gattttccac
     2401 cgtgatagga aacgatgccc aagttgggtt cgagcgtagt aaacgggtaa tcggcaattt
     2461 tcggtttggc agccgaaatg gaagaaagca aagttgactt tcccgcattc gggaaaccta
     2521 ccagaccgac atcggcaagc agtttcagct ccatgataac ggtcatttcc tgcatcggct
     2581 ctcccggctg cgcaaaacgc ggagcctgac gggtggccgt cttgaaatgc cagttaccct
     2641 gaccgccgcg gccgcctttg agcaagacca cttcctgtcc gtcttctgtt acgtcacaaa
     2701 gatactcccc tgtctcggca ttataaacta ccgttccgca gggcacttct attattttat
     2761 ccgcaccgtc ttttccgaag ctacgtcctt tgctccccga ttcaccatga ccggccattg
     2821 catgacggtc atacttcaag tgcagcaatg tccagtaatt acggttaccg cgcaagatga
     2881 tatgacctcc tcttccacca tcgcccccgt cgggacctcc gttaggacaa tatttctcgc
     2941 gcctcatgtg cgtagagcct cttccgccct tacccgagcg acagtatatc tttacgtaat
     3001 caacaaaatt cgattcagcc atattttttt aaagagttaa agtagtcagt agttagagca
     3061 gttaattaga acactccggc tactgactta tttatttata atattgtatt attacaattt
     3121 atctactgct tcgcagattt cagcgaagat accttccata gtacccaagc cgttgatgtg
     3181 ttggtatttc ttttcgttct tgtaccagtc gatcagtgga gcagtctgtg aatgatatac
     3241 atgcagacgt ttcttgattg tctcttcgtt atcatcagca cgaccggaat ccttgccacg
     3301 tttaataaga cgtaccatca gttcttcttc cggaacatcc aagtcaacca ttacagaaac
     3361 gtcctgtcct ctttctgcca acattttctt taatgcttct gcttgtgcaa ttgttcttgg
     3421 gaaaccgtcg aaaattacac ctttgctatc tttgaagctg tcgaatacgc ttgccagaat
     3481 atcaatcatt aattcatcag gaatcaattg accttggtcg atgtaacctt tagctgtttt
     3541 acccagttct gtgccattct tgatttcagc acgcaataca tctcctgtcg agatgtgatt
     3601 gattccatac ttttctacga tacgttcgct ctgtgttcct tttcctgaac ccggagcacc
     3661 gaaaattacg atgttcaaca ttttgttatt tacaatttaa cgatttacta tttaccattt
     3721 aaactggtac ctatttaata ttaatctact actgtataaa tatcgggata attacgtccg
     3781 aaaccatcat aatccaaccc gtaacctacg ataaagtcgt tcggaatttc catcgctaca
     3841 tattcaatgt tgaggtttac cttgagcttt tcaggtttca ccaacagaga agcgatatgg
     3901 atagcttcgg gattgcgtgt acctaatgtt tcgagcagtc gctgcatcgt cagtcctgtg
     3961 tctacaatat cttctacgat tacaatggta cgtccggcaa tgtcttcatt caggccgatt
     4021 acctctttaa tcactccggt ggaagtgatg ccctgataag acgccaactt cacaaatgag
     4081 atttcacaag ggatggtgat gtgcttcagt aaatcagcgg taaacatgaa cgaaccgttc
     4141 aacacactaa ggaaaagcgg attcttacct gccaaatcgc ggttaatttc gttcgctacg
     4201 cgaatcactt ctttctgaat ttcttgttcc ttaatggaaa cggtaaacaa tttgtctttt
     4261 atctgaatgg tatccataac cggtaattta aaaataacct tgcaaaaata cgatttttta
     4321 ttctaccccg tgcatcatct tctgtaattt cttcgagaga aggaacagaa tcaacgaagc
     4381 aacaccggac atcacgacga ataccataaa gaaatcatac atggtagcaa tctgataacc
     4441 aaagattgac ttcacttttc cggcttccgg atagagtccg ctcaacattc ccgcaaattt
     4501 attagctgtg gcagtagaca gataccagat tcccatcatc aaggaggcga aacgcagcgg
     4561 actcaattta tttaccattg aaagtccgat aggcgacaaa gctatttcac ccatggtatg
     4621 aataaagtaa agtcctgtca gccaaatcat gctcactttc actccgggaa ctgcatcttt
     4681 cactccgaaa cagatgaaaa gataacctaa agaaaggagt aacagaccaa tcgcttgttt
     4741 ggtaggagaa gcaggttcca tctttcgctt gttcaggaaa ccccatacac ccggcatgat
     4801 atatgccagg acaactacaa acagtggatt gaaggattga aaccatgaag ccggcatttc
     4861 ccaaccgaaa atgtcacgat tcgtctgttc ggacgcaaag agagttaaag aagctcccgc
     4921 ctgttcgtag gctgcccaga agaagatgac aaagaaggct actatataga taacgaaaat
     4981 acggctgcgt tctatttttg tcaatgaacc gtctaacagg atcagaacag ggaaaacaat
     5041 gcaggcggta aaaatgccga tactcaccca atcgccttca aatgcatagt taaagaaggc
     5101 tattaaagca atggtaagaa ttgtgattac aagggtatta cgtactttgg tacgtttgtc
     5161 catcttcggg tgtgagatat ggtcggcctt gtcttctttc ttttcacgtt tagcatcggg
     5221 gataatacca atcggttctc cggaaggaga aaaaagatat ttattctttt gagtctcgaa
     5281 aagaacaacg gtgaacagtg tcatgattcc ggctgcaaga aatccccatt taaagtcatg
     5341 cggatcaccg gtatcaccca gataaccaca aatcaaagga gcagcaaaag agcctacatt
     5401 cactcccata taaaaaatgg tgtatgcagc atccaaccgc ctgtctccgg gttcgtagag
     5461 ctgacctacc agagaagaga cagtgggttt gaagcaacca ttgcccaaga tcaggaagcc
     5521 tagtccgcca tacatcatcc agtgggcaag gttcgtatta tctaaagtgg aagcactcat
     5581 aaacatcagg aattgtccga ctgccatcat caccgctccc caaaacacgg aacgacggat
     5641 tccccaatat ttatcggcaa tgtatccgcc aatcaacggg gttaaataaa ctagtccggt
     5701 atagctgccg tagatggatg ctgccgcttc tttgtcaaac aataatgcct gcgtcaggaa
     5761 aagaataaag atcgcacgca taccgtaata actgaaacgt tctgccgtgc ttgtcgcgaa
     5821 aatcaaataa aggcctttcg gatgcccttt caatgcactc atgaatttat gtgtttagta
     5881 gtttatgggg tgcaaaggta cagaaaaagt agattagatg cttctcttat caaacagaat
     5941 aatagggggg aatagtaaaa acgagcataa aaaatcctac tgatccactt cattactttt
     6001 ttagcagtgt aaataataaa gtggagatcc atcttaaatg taggttagct accaccttag
     6061 ccaaaagtaa attcgacatt ttcgatactg gcaaaaagca ttccttctct tttcctcaaa
     6121 aagatcttgt cttctcgggc cagccaacca atagcaagag ctacgtcttc aaacgtcaaa
     6181 cttaattcac ggcacaaatc gaacattgaa agttcacctt tttcatttaa gatgcgccat
     6241 actttcccgg cattcaagcc aatttttgtc ttttccatca tgcaaacttt agaagattaa
     6301 acaatccgtt atttagattc taattcattg tgagcacagg aaattaatgt gatgcacatt
     6361 acctatctcc aaagataaca tttttatcgg aaacggcaaa taatcaaagg cttaatcagg
     6421 ggaaccgcat taaaaatttg tttaagaagg tatggagatg aaggaaaccg taaccacaca
     6481 tgaggtatat agcttaatac tgcctaatgt cggcactata cgacaatttt gaagttgagt
     6541 tattaataga caactgaagt cagctattta gtcaactgca gttgaccatg tagccgacag
     6601 tagtcatcta agtagccaac tacagttggc taatatcatg ccaactattt caatccggtc
     6661 ttcaatcata ttcgttctcc tatgtcttgc catattgaag aaacacctaa gcttttgctt
     6721 tgaccgggct tctttcttaa gggtgtgaac agtgtgaaag atgtgaagaa ttaaaaagag
     6781 aaccttaaat cacaacaaac atctgtcaca ctacaactta cgtgtccgtg aaacttgtga
     6841 aaggtacaaa atgattattt ttaataaatc aaaccaccac gagtttgatt catttccctg
     6901 cccccaacaa gtcatctcct tatgattaac aagttttctt cccacaacaa acgggaaaag
     6961 tcagaagaat catgtacatt tgtaatccga aaactaaaag aacatcgcaa tgaaaatatt
     7021 tccaagcagc agtatcaaga aattggacgc ttataccatt gagaacgaac ctattacatc
     7081 aatcgatctg atggaacgtg cagcaaccgt attaacaaaa gccatcacag acagatggaa
     7141 tacggaaacg ccggtcacta tctttgccgg accggggaat aatggcggag acgctctcgc
     7201 cgtagcccgc atgatggctg aaaaaggata taaaatcgag gtatttctct tcaacacgaa
     7261 aggagaactt tcacccgact gccagaccaa taaagaactg gtagaaatga tggaagaagt
     7321 aaaattccac gaaatcagta cccaattcgt acctcccgtc ctaacgcccg atcacctggt
     7381 aatcgacgga ttattcggtt caggcctgaa caaaccgttg agcggcggat tcgctgccgt
     7441 agtgaaatac atcaattcct cccctgccat ggtagtagcc atcgacattc cttccggact
     7501 gatgggagaa gaaaatacat tcaacgtaaa agctaatatt atccgtgccg acgtaacttt
     7561 cagtctgcaa ctgccgaagc tcgcctttct tttcgcagag aacacggaat ttgtcggaga
     7621 atgggaattg ttggacatcc aattgagcga agacggcatt gaagagatgg aaacgaacta
     7681 cgaaatgttg gaaatagagc aaatccggtc actcatcaag ccacgcaaac agtttgccca
     7741 caaggggaac ttcggtcatg cactattgat tgccggttca aaaggaatgg caggagcctc
     7801 tgttctcgct gcccgcgcct gcctccgttc gggagtaggg ttgctgactg tccatgcgcc
     7861 aatgtgcaac aacgacatct tgcaaacctc catacccgaa gcaatcgtag aaaccgacat
     7921 caacgaaacc tgttttgccg tacctaccga cacggacgac tatcaagcag tcggcatcgg
     7981 cccgggactg ggacgaaacg aggaaacgga agctgccttg ttggaacaac tggaacactg
     8041 ccagactcct gttgtggtgg atgccgacgc acttaatatc cttgccaacc accgccatgc
     8101 ccttacccac ctgccgaagg gttccatcct caccccgcat ccgaaagaac tggaacgtct
     8161 gaccggcaaa tgccaggact cttacgaacg tctgatgaag gcttgcgaac tggcccgtgc
     8221 cgcccatgtt cacattattt taaaaggagc ctactccgcc atcatcaccc ccgaaggtaa
     8281 atgtttcttc aacccaaccg gaaatccggg aatggcaacc ggaggtagcg gtgacgtact
     8341 gaccggagta atcctggcgc tgctcgcaca aggttacccc accgaggaag ccgctaaaat
     8401 cggcacttac attcacggac tggcgggcga tgtcgctcaa aagaagcaag gaatgatcgg
     8461 aatgatcgca agcgatatta tcacctgtct gccgacagca tggcgacttg taagcgaata
     8521 aaagttaaga agttaccctt ttttcaataa cttcattaac tttgttttca aaaccagtta
     8581 aaaagaaccg aatatgaaaa agttgattat agcagcagga ctacttatga caacgtccgc
     8641 ctatgcacaa accgaagtac tgacgggggt tacccgagga aaagactatg gagtggttta
     8701 cagtcttccc aaaacccaaa tagaacttga aataaaagcc aacaaagtca actatactcc
     8761 gggagaattc agcaaatatg ctgatcgtta cctgcgactg accaacgtct ccgccgaccc
     8821 tgaagagtat tgggaactag ctagcgtaaa agtgaaatcc gtaggtgtgc ccaacagcga
     8881 aactacgtat ttcgtaaaat tgaaggataa gacagtagca ccgcttatgg aactgacaga
     8941 ggatggcatt gtgaaaacga tcaatgttcc ttacagcaac agcagtgtaa gcaaaaaagt
     9001 tgctcccgcc cccgcagtcc tccaaaagaa agcgaatcct cgcgaattcc tgaccgaaga
     9061 gattctgatg gctagttcta ccgccaagat ggccgagctg gtggctaaag aaatctataa
     9121 catccgcgaa agcaaaaatg ccttattgcg cggacaagct gataatatgc cttcagatgg
     9181 ggcacagctt aaaattatgc tcgacaatct gaatgcacag gaagaagcca tgacgcaaat
     9241 gttctccggc acctgcaaca aagaagagag aacattcact gtccgcctta cccctgacaa
     9301 ggaattcaac aatgaagttg ccttccgctt ctcgaagaag ttaggtgtag ttgccaacaa
     9361 tgatttggca ggaactccgt tttatatcag tctgaaagac ctgaaatcgg tcaagatacc
     9421 acaggaagac gataagaaga agaaagattt ggatggaatc gcctacaacg tacccggaca
     9481 agctatggtt acactgactg acggtaaaaa gaaactttac gaaggtgagc ttcctattac
     9541 ccaattcggt gtgatagaat atctggctcc ggttttgttc aacaagaatt ctaccatcaa
     9601 agtttatttt gatccgaata cgggaggatt gctcaaagtg gacagagaag aagggaaata
     9661 gaaaaacgag gaagtgaact tctaaaaaac aaagaatatg gttggtgaag gacatgcatt
     9721 cgacatgata cgccgaataa aagagggacg ggaagcttcc cgcctacgtc gtgaacgtgc
     9781 taacgataag ttgaagcatc taaaccgtgc aaacgaacct tatccactac ccaacaccac
     9841 ccccgaagaa atggaacgta tcatccacga ctcggagaaa aagaaagaga aagacagcaa
     9901 ttattttgtt tggggaacgc ttattatcat ggggggcctg atagcaattg ccgtcatact
     9961 ttgggctgta tttatcaaat aaataataat aagttcctat ttatacgact ggtatcacca
    10021 gttttataaa tccatctttc tgcatttgag aaagataagc cgatacacgc gactcgtagc
    10081 cctcttcatt ttgaaagtgg tctgcgagtt tttctataat ctcacgaaca ttgcgttttc
    10141 catctatcag ttcccataca gccgtaccgt gttcttccaa tttcacatga agttctttcg
    10201 acattccttt cggcacaagg aagcgttgca tccacggata tttaaaacgg ggaaaggaga
    10261 gcacaattgt ctccccttcc ctttctgctg taatatgttc actgcgacag ggaatgacct
    10321 ctaacaggtt gattttctct ttggcagcca tacttcttat tttttatttc agagtattca
    10381 tactgatact cttctgttta caccttgata caaaattcct ttgttacttt aggtattgaa
    10441 tttcccagtt acttttggat attcgcctct tccaaaccgt atcccttctt cttgttctct
    10501 gccttcaaca tcaaagccac aatcagagca agcacaccaa aaagagcaaa aatagtcatc
    10561 ggcaacgtgt agtcataagt ctgtgcaccg tctactaccg gacctttgca ataagtattc
    10621 aacacccatc cgatcaacaa aggaacaccc atcaatcccc agttctgtac ccagaaaatc
    10681 aatgcgtatg cggtacccaa ctgtttttcc ggaataatct tcggaacaga cggccacata
    10741 gctgaaggca ccaacgagaa ggcaaatccc aatataatca tgatgatagt agcaaaccac
    10801 catatattca gtataggcag agcaaacatc gtatgcacaa aaataagcat cactgatccg
    10861 attatcatca atgtggctcc cttaccgata cggtcataaa gcgagccgaa caacggagtc
    10921 aggataatcg caccaatcgg caacaatccg ggaatcgttc ccgccaactt cggatctaca
    10981 ttatacttct gcaccatcaa gtcggcagca tacttgataa aggggaatac agccgagtag
    11041 aacaatacac atagtaatgc aatcagccag aatcctttat tggtaatgat atacacaata
    11101 tctttcatac ggaatggctc ttccggttcc aatccctctg catccaaaga agcatccaac
    11161 ttcttatcat agaaagtata aaggaagaaa gcaatcgtac ccacgcacaa cataatcaga
    11221 caaaacaaaa tcggagcagg aatattggta tggaatgtgc cactctcatc cgtagatccg
    11281 aaaaagtcgg ccaaaggaac cgtaagcacc attgccagag ttgttccgat acgtgccgta
    11341 gccatttcaa gtcccatagc caacgccatt tccttaccct tgaaccattt cacgataatc
    11401 ttggaaactg tgataccggc aatttccaca cctacaccga agatagcata ccccaatgca
    11461 gccagggtta cctgtgtttt gaatccgaag agcatggcac cttccggaaa agtagtagaa
    11521 atcgcatagt atttcaatcc acaaccaaac accatcaata agcaagcccc cattccggtg
    11581 aaacgaactc ccatcttatc caaaatgata ccaccgaaaa tcagcatcaa taggaataca
    11641 ttaaaccacc cgtaagcgct tgtgaagaaa ccataatcaa gactgtccca tagtagttct
    11701 ttctcaagca tgggttttag aggagacatt acgtcggtga ggaaatagcc gcatagcata
    11761 gtaaatgcga ctaatgctag aacactccat cggagtacgg cggagtcatt caatttctgt
    11821 ttcaaatgtt ctgtcattgt tatatttaaa aatagtagtt aataatcttc atacgaccaa
    11881 caaaggtagt taaatctcgt ttgtttctat caaaaagaga ttgtttttac aagaaaaagt
    11941 taagtgcgga ttacactgac cacgcggaag attgaaaatc cgtgtaatct gcgtaatccg
    12001 cacttaaata tcaaagaaat gcagcatccg tctgcacctt cccattaatg gttttccccc
    12061 aaagtcttac ctgacaacgg agtgaattac tctgctgcag gagcaggagt ttcagcagcc
    12121 ggtgccggag tttctgtagc aggtgcattg gtagcaggag cttcagtttg cggcgcagcc
    12181 gtacctgcgg gtaagttata cgggttagtc tgttgttctt tctgtgcctg ttccaacact
    12241 gcgtctttag caacagcaga gcgaggaact acataagcag tagcaatgct cattaccacc
    12301 atgaagatag ctaagcccca tgttgctttt tccagaaaat ctgtagtctt gcgcacgccc
    12361 atgatggcgt tagatgaaga gaaaccagaa gcaagtccgc ctccttttga gttctgaatc
    12421 agcacgatga aacacatcaa caaggctgca ataaccatta agataacgaa taataagtac
    12481 atttttagtt attttgaatt agcgttaata atcaatttct ccaaaaatct gatttggtct
    12541 gcaaagtaag catttttttt tggatatttc aagcttaatt ttttaattat ttcaagagct
    12601 tttgaatatc gttgctgttt aacatagatt tttgccaaag tttccgtaaa acagctgtca
    12661 tcttcctctt cttccttcat cgtttcttct tcggtaggtt cgtccgaaga ggttggcgaa
    12721 gatggcattt cttctcttaa aggtttcatg cagaggggag agtcgctctc gctcttttct
    12781 ataaagtcgt caatcagttc gtagccttta agtttgggcg tttcttcgga cgactgttcc
    12841 gtggccggag tctcctccaa aagataagaa gtgtaatcca tcgaatagtc gaagctggtg
    12901 cgggcagtca cctcttcggg tactgtggac aagaaagcgt cgatcaatgc taatgtgcgg
    12961 tctacggacg gttcgtcttt cagcacctcc gtgagaggta ctcccttttt ccgtgcctgc
    13021 acatcatagc ggtcaccttc aatcaaccga aacaactgcc gtctgtctgc aatgtaaaga
    13081 actgctttcc gcagttctcc accaaaacta atatcatgga gaatatacag attcttcaga
    13141 tacagcagac gaagtgactg aaaatacgga tacctcgcaa gaagattgcg cagttcgtac
    13201 aaagtatccc tattcagcgt ctcgggatgc tgaatccatt gttgaaagtt aacagaagtc
    13261 atttatatta ccagtttgct acagttgcat taaaaatttg gtcggtgatc tctttagaca
    13321 tttcagcaat caatccgtcc tgtacggcag tcagcaactg gctagagtcg taggtacgga
    13381 acgcagaaaa ctgttgttca aagtcttcgg catgattggt attgttgaca aaacgcacat
    13441 tgacggtaat agtcaacttc gtctccgaag aataaccgtc ggcagatact gcctggttgt
    13501 actgattgta tcctgtgatt tctccgtcaa tctgcaagtc cgcattctga ttcggcttga
    13561 gcagttgcag acgggtctgc cggatgaaga tatctttcag gtcctcattg aatttggttg
    13621 ccaacggagc atatacatac tccgacttga tcgggaagtc ggctatcgaa atagtcttta
    13681 ccttatcata attgatagac gatccgttaa acttatagga aacagtgcac gcaatgacta
    13741 ccaacggcaa gccgaacagt aacaaagggc gtattatttt cttaatccaa ttcatattct
    13801 tttatttttc tataaagtgt acgctcggaa atattcaagt ccttggccgc actcttccgc
    13861 tttccatgat gcctctcaag tgctttgcgt atcatttctt tctccacttc gtccagtgac
    13921 aaaggggatt cttctacata ttcttccgtg tcttgtatgt catcgtcatc cttgcaaacc
    13981 gtaggctgca tggtgtgaat gatagcaggt accgaaggtt gatgcgccgt cactaccgga
    14041 gtagtaacca ccgttcccat ttgtcctacc tgccccacct gtccggcacg ttccgccatc
    14101 aggttgtgca ccatcttctt cagctccgcc acttcctggc gcatatcgaa cagaacagaa
    14161 taaagaatct cccgttcgct ctcaaagcct ttactctcac gcgttcccat cagcgcggga
    14221 agacgttgcg tattttgtgc gggaagataa ttctgcaaga tagcagcaga gatctcccta
    14281 ttggtttcaa tgatagatat ttgctcggtg atgttcttca actgacgcac gtttccgggc
    14341 cacgggtaag ctaacaactc tttcttcgca tcctccgtca actgaatagc aggcatccga
    14401 tatttctctg caaagtctgc ggaaaactta cggaacaaca aaagtacatc gtcaccacgt
    14461 tcacgcaaag gcggtatttg gataggcacc gtattcaacc ggtaatataa atcttcacgg
    14521 aaacgtcctt ctgcaatcgc ttgtgtcaga ttgacgttgg tagctgccac cacacgcaca
    14581 tccgtttttt gtactttgga cgaacctact ttcataaact cgccactctc cagtacacgg
    14641 agcaaacgtg cctgggtaga catcggcaac tcccctactt catcaagaaa aatagtacca
    14701 ccgtcagctt cgccaaagta ccctttccgt tcgccaatcg caccggtaaa cgcacctttc
    14761 tcatgtccga acagttcgga atcaatcgta ccctccggaa tagcgccaca gttgacagca
    14821 atatactgcc cgtgcttcct ccgactatat tgatgaataa tctgcggaaa actttctttt
    14881 ccgactccac tttctccggt aatcagcaca gacaaatcgg taggagctac ctgaatggca
    14941 acatctatgg cgcgcgacaa tgcttcagta tttccaataa taccgaaacg ctgtttcact
    15001 tgttgtatct ctgctttcgt catcactcgt ttttaatctt cgtctactgt atccagcttc
    15061 agtttatcac tatcgtcacg tttctcgtaa tactgtttac gcaacggatt ggcacgagcc
    15121 actttttccc gctgacgatt acggaacacg tcgatggcaa catagattgc ctgacggaaa
    15181 gaatcttcac aagccactcc
//
