LOCUS       gnlProkkaCLFPKOLF_69    8934 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|CLFPKOLF_69.
ACCESSION   gnlProkkaCLFPKOLF_69
VERSION     gnlProkkaCLFPKOLF_69
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2024-11-30 23:50:57
            Original ID  :: gnl|Prokka|CLFPKOLF_69
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 8934
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..8934
                     /aStool="rule-based-clusters"
                     /category="PKS"
                     /contig_edge="True"
                     /core_location="[367:8150]"
                     /cutoff="20000"
                     /detection_rule="(APE_KS1 or APE_KS2)"
                     /neighbourhood="20000"
                     /product="arylpolyene"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      368..8150
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(APE_KS1 or APE_KS2)"
                     /neighbourhood="20000"
                     /product="arylpolyene"
                     /protocluster_number="1"
     cand_cluster    1..8934
                     /SMILES=""
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(APE_KS1 or APE_KS2)"
                     /kind="single"
                     /product="arylpolyene"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..8934
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="arylpolyene"
                     /region_number="1"
                     /rules="(APE_KS1 or APE_KS2)"
                     /tool="antismash"
     CDS             complement(2..355)
                     /locus_tag="ctg69_1"
                     /transl_table=11
                     /translation="MQPVYIQRIASIHPQGNHSQENNPKVNDSLDVAANRPFLQACEPD
                     YKDIIANATLRRRMSRIVKMGVACGLECMGELSPEKIGGIITATGLGCLVDTEKFLNNL
                     LDNEERMLNPTPFI"
     CDS             complement(368..1675)
                     /NRPS_PKS="Domain: PKS_KS(Iterative-KS) (152-423). E-value:
                     1.2e-38. Score: 125.0. Matches aSDomain:
                     nrpspksdomains_ctg69_2_PKS_KS.1"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     arylpolyene: APE_KS2"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1022:Beta-ketoacyl synthase (Score: 253.5; E-value:
                     6.3e-77)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg69_2"
                     /sec_met_domain="APE_KS2 (E-value: 2.7e-113, bitscore:
                     368.4, seeds: 16, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKIYVTGLGVVSGIGIGVSENIEALQQGKHGIGKVTLFPTALDVP
                     VSEVKRSNEELKQLLSLPPQRTVSRTALLGMIAAKEAMEDAGLNLRISSNQPKNQLPNQ
                     SVTSQKDQQPLRIGFISATSVGGMDLSERFYESFKKNPKQGRLREVISHDCGASTELIA
                     SYLGINDFITTISTACSSAANAIMLGARLIKHGQLNAVIVGGTDALCRFTLNGFNSLMI
                     LDKIHCRPFDRSRSGLNLGEGAGYLVLQSESSLQRVPYCELSGYANTNEAYHQTGSSPE
                     GDGAFLSMSEAIASSGISPEDIDYINVHGTGTPGNDASEGMALRRIFGEHVPPFSSVKA
                     FIGHTLGASEGIEAVYSVLSIDKGMIYPNLNFTEPMPETELLSETGVKSETGLIPETSF
                     QEGVPIRHVLSNSFGFGGNDSSLLFSATNFPKRTNL"
     aSDomain        complement(407..1219)
                     /aSDomain="PKS_KS"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg69_2_PKS_KS.1"
                     /domain_subtypes="Iterative-KS"
                     /evalue="1.20E-38"
                     /label="ctg69_2_PKS_KS.1"
                     /locus_tag="ctg69_2"
                     /protein_end="423"
                     /protein_start="152"
                     /score="125.0"
                     /tool="antismash"
                     /translation="HDCGASTELIASYLGINDFITTISTACSSAANAIMLGARLIKHGQ
                     LNAVIVGGTDALCRFTLNGFNSLMILDKIHCRPFDRSRSGLNLGEGAGYLVLQSESSLQ
                     RVPYCELSGYANTNEAYHQTGSSPEGDGAFLSMSEAIASSGISPEDIDYINVHGTGTPG
                     NDASEGMALRRIFGEHVPPFSSVKAFIGHTLGASEGIEAVYSVLSIDKGMIYPNLNFTE
                     PMPETELLSETGVKSETGLIPETSFQEGVPIRHVLSNSFGFGGNDSSLL"
     CDS             complement(1679..1960)
                     /NRPS_PKS="Domain: PP-binding (22-68). E-value: 5.7e-11.
                     Score: 34.7. Matches aSDomain:
                     nrpspksdomains_ctg69_3_PP-binding.1"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PP-binding"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg69_3"
                     /sec_met_domain="PP-binding (E-value: 1.1e-11, bitscore:
                     34.7, seeds: 164, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNNLDQTKRELMDEVKGKLIEELNLEEITPEDIDDEAPLFGDEGL
                     GLDSIDALEIILILEREYGIKIENPSEGKQIFYSVCTLTDYIIANRKA"
     aSDomain        complement(1757..1894)
                     /aSDomain="PP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg69_3_PP-binding.1"
                     /evalue="5.70E-11"
                     /label="ctg69_3_PP-binding.1"
                     /locus_tag="ctg69_3"
                     /protein_end="68"
                     /protein_start="22"
                     /score="34.7"
                     /tool="antismash"
                     /translation="LNLEEITPEDIDDEAPLFGDEGLGLDSIDALEIILILEREYGIKI
                     E"
     CDS             complement(1953..3803)
                     /NRPS_PKS="Domain: PKS_KS(Iterative-KS) (159-409). E-value:
                     3.3e-29. Score: 93.8. Matches aSDomain:
                     nrpspksdomains_ctg69_4_PKS_KS.1"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     arylpolyene: APE_KS2"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1022:Beta-ketoacyl synthase (Score: 178.3; E-value:
                     4.1e-54)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg69_4"
                     /sec_met_domain="APE_KS2 (E-value: 2.8e-109, bitscore:
                     355.2, seeds: 16, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MEYPLNIYITAHTLISSLGFGISENKKAIHDYRSGIRMQEAGRIS
                     DSPILAGMIDSVELEKRAKELLEKRAKELDISSYTRLEQLFILTIQEVISQSGVNLQES
                     DCALLLSTTKGNIDLLSNQEKRTNSDKPSGSVQSTIDNPSFLQELSADSPTFLWKMAER
                     IGHFFEAANQVEVISNACISGVSALVVAKRWIESGRYKRVIVAGGDILSHFITSGFLSF
                     RSVSAHRCRPYDIQRDGLSLGEACGAVLLETQGNANHIILSGGAISNDANHISGPSRTG
                     DGLALAINQAMEEAGALPEDISFINAHGTATVYNDEMESKAIHLAGLSAVPVNSLKPYF
                     GHTLGASGIIETILCIEQLKEGIYYGTLGYETLGVPMPIIVYSTHQPMPMKCCIKTASG
                     FGGCNAALVLSLPDAHLKQKTDSLASCKAAVESANTVTIKPGVVENQGTAIFNSSETDF
                     APFIREAYKHLGENNMKFYKMDNLCKLGYVAAGYLLKDTNYRPEEIGIILANASASLDT
                     DCRHQAIINKEGDKAASPAVFVYTLPNVVLGEICIRHKIQGENTFFVCQQSDTASLEDY
                     ARIVMAKGKLRTCIIGWCELLDGHYQAEFKQLNNISTIYE"
     aSDomain        complement(2577..3326)
                     /aSDomain="PKS_KS"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg69_4_PKS_KS.1"
                     /domain_subtypes="Iterative-KS"
                     /evalue="3.30E-29"
                     /label="ctg69_4_PKS_KS.1"
                     /locus_tag="ctg69_4"
                     /protein_end="409"
                     /protein_start="159"
                     /score="93.8"
                     /tool="antismash"
                     /translation="MAERIGHFFEAANQVEVISNACISGVSALVVAKRWIESGRYKRVI
                     VAGGDILSHFITSGFLSFRSVSAHRCRPYDIQRDGLSLGEACGAVLLETQGNANHIILS
                     GGAISNDANHISGPSRTGDGLALAINQAMEEAGALPEDISFINAHGTATVYNDEMESKA
                     IHLAGLSAVPVNSLKPYFGHTLGASGIIETILCIEQLKEGIYYGTLGYETLGVPMPIIV
                     YSTHQPMPMKCCIKTASGFGGCNAALVL"
     CDS             complement(3788..4231)
                     /locus_tag="ctg69_5"
                     /transl_table=11
                     /translation="MKRKTNQQIAALTNRTTFRVRFSEIDSMQIVWHGEYVRYFEDGRE
                     AFGKQYGLDYMSIYREGYMVPIVDLTCQFKQSLSFGEEAIIETRYIACEAAKIKFEYVI
                     YRATDQSVVATGSTIQVFLNLNKELELINPPFYLEWKKKWNIL"
     CDS             complement(4228..4662)
                     /locus_tag="ctg69_6"
                     /transl_table=11
                     /translation="MNREAVIQGEGILNLIPQRPPIVMVDSFFGFEENRSYSGLTVTTD
                     NLFCEAGRLQEPGIIEHIAQSAAARIGFIYTRQGEKVPLGFIGSVDKLKIYNLPEAGMK
                     LFTEITVVQEVFDITLISAQVKTEEELIAECKMKIFIKKE"
     CDS             complement(4659..5729)
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1042:O-methyltransferase (Score: 126.4; E-value:
                     2.4e-38)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg69_7"
                     /transl_table=11
                     /translation="MQQNKYDKEPLTAVEAQRLAQEIAFGPIVFQVSRLMLKFGIFQLL
                     ADERKGMTQEEISKACGLPSYGAQVLLEASLTIGTVLLREGRYCLAKAGWFLLNDKMVR
                     VNMDFNHDVNYQGMFHLEEAITNGRPEGLKVFGEWSTIYEGLSSLPSQVQKSWFGFDHY
                     YSDCSFDEALAIVFARHPKTLLDVGGNTGRWATKCVSYDDTVEVTIMDLPQQLEMMRQQ
                     TKELPGATRIHGHGANLLDPEVPFPTRFDAIWMSQFLDCFSEEEVTSILTRAARSMNRE
                     SRLYIMETFWNRQKFDTAAYCLTQISLYFTAMANGNSKMYHSDDMQRCIEAAGLEIEEI
                     HDHLGMGHSIVQCRLK"
     CDS             complement(5716..6651)
                     /locus_tag="ctg69_8"
                     /transl_table=11
                     /translation="MSTWKGKTRGGTFGYLFFIYLIKYLGITAAYLFLSLVVLYFIPFA
                     PKATKSTWFYARHILKYNRIRSLKMLLLNYYRLGQILIDKVAIGNGKVNQYQFKFEQYP
                     EFLQLLNSEQGVIMIGAHVGNWEIGVPFFDDYGKKINIVMYDAEHRRIKEILEKNGQDR
                     EFKIIPVNEDNLTHVFRITEAINQKEYVCFQGDRYLNKEKLLPGILLGQKAPFPAGPFL
                     LASRMKVPVVFYFAMREPGRTYRFHFIIAEPVVRTKEKKAEMALLEQYTVALEQILKRY
                     PEQWFNYYPFWEPAGKQSPDLKEKQKDATE"
     CDS             complement(6654..6905)
                     /NRPS_PKS="Domain: PP-binding (7-75). E-value: 3.8e-14.
                     Score: 44.9. Matches aSDomain:
                     nrpspksdomains_ctg69_9_PP-binding.1"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PP-binding"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg69_9"
                     /sec_met_domain="PP-binding (E-value: 7.4e-15, bitscore:
                     44.9, seeds: 164, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTNEEIIEKIRTTLAEEFEVDIDVIQPDAPLMETLELDSLDLVDM
                     VVLVEKNFGFNVTGQDFAGIKTFQDFYDLVITRMQEAK"
     aSDomain        complement(6681..6884)
                     /aSDomain="PP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg69_9_PP-binding.1"
                     /evalue="3.80E-14"
                     /label="ctg69_9_PP-binding.1"
                     /locus_tag="ctg69_9"
                     /protein_end="75"
                     /protein_start="7"
                     /score="44.9"
                     /tool="antismash"
                     /translation="EKIRTTLAEEFEVDIDVIQPDAPLMETLELDSLDLVDMVVLVEKN
                     FGFNVTGQDFAGIKTFQDFYDLV"
     CDS             complement(6927..8150)
                     /NRPS_PKS="Domain: PKS_KS(Iterative-KS) (65-405). E-value:
                     2.2e-53. Score: 173.5. Matches aSDomain:
                     nrpspksdomains_ctg69_10_PKS_KS.1"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     arylpolyene: APE_KS1"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1022:Beta-ketoacyl synthase (Score: 295.4; E-value:
                     1.2e-89)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg69_10"
                     /sec_met_domain="APE_KS1 (E-value: 1.5e-160, bitscore:
                     523.8, seeds: 15, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKRVVITGMGIYSCIGKNLDEVKDSLYNGKSGIGIDPVRKELGYF
                     SALTGILERPDLKKLLDRRKRLCLPEQGEYAYLATLEAFRNAGIDDAFLEANEVGILYG
                     NDSSAAPVINAVDIIREKKNTALVGSGSIFQSMNSTVTMNLSVIFKLRGVNFTIAGACA
                     SGSHAIGMGYLLIKSGLQDCILCGGAQEVNPYAVGSFDGLSAFSTQEAEPEKASKPFDK
                     RRDGLIPSGGAASLVLESYESAVKRGAPILAEVIGYGFSSNGDHISVPNVDGPKRSLQM
                     AIKDAGIALEQISYINAHATSTPVGDLNEAKAIAEVFEGHHPYVTSTKSMTGHEMWMAG
                     ASEVIYSILMMNNGFIAPNLNFEEADEASAQLNIPTQRVNLEFDTFLSNSFGFGGTNST
                     LIIRQIKE"
     aSDomain        complement(6936..7955)
                     /aSDomain="PKS_KS"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg69_10_PKS_KS.1"
                     /domain_subtypes="Iterative-KS"
                     /evalue="2.20E-53"
                     /label="ctg69_10_PKS_KS.1"
                     /locus_tag="ctg69_10"
                     /protein_end="405"
                     /protein_start="65"
                     /score="173.5"
                     /tool="antismash"
                     /translation="RLCLPEQGEYAYLATLEAFRNAGIDDAFLEANEVGILYGNDSSAA
                     PVINAVDIIREKKNTALVGSGSIFQSMNSTVTMNLSVIFKLRGVNFTIAGACASGSHAI
                     GMGYLLIKSGLQDCILCGGAQEVNPYAVGSFDGLSAFSTQEAEPEKASKPFDKRRDGLI
                     PSGGAASLVLESYESAVKRGAPILAEVIGYGFSSNGDHISVPNVDGPKRSLQMAIKDAG
                     IALEQISYINAHATSTPVGDLNEAKAIAEVFEGHHPYVTSTKSMTGHEMWMAGASEVIY
                     SILMMNNGFIAPNLNFEEADEASAQLNIPTQRVNLEFDTFLSNSFGFGGTNSTLIIRQI
                     "
     CDS             complement(8177..8905)
                     /NRPS_PKS="Domain: PKS_KR (3-169). E-value: 1.3e-16. Score:
                     52.9. Matches aSDomain: nrpspksdomains_ctg69_11_PKS_KR.1"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) adh_short"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1001:short-chain dehydrogenase/reductase SDR (Score:
                     213.3; E-value: 6.4e-65)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg69_11"
                     /sec_met_domain="adh_short (E-value: 3e-36, bitscore:
                     114.6, seeds: 230, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKYALVTGGSRGIGRAVSCKLAEMGYFILINYQSNDAEAEKTLQL
                     VQEKGSNGEIMKFDVTDPAAIALALNNWASQHPDEYIEVLINNAGIRKDNLMLWMTGEE
                     WNKVLDISLNGFFYVTQPLLKNMLVKRYGRIVNIVSLSGIQGMPGQANYSAAKGGVIAA
                     TKALAQEVAKKKVTVNAVAPGFIRTDMTEGIDENEWKKHIPAGRFGTAEEVADLVGFLA
                     SPASSYITGEVISINGGLYT"
     aSDomain        complement(8399..8896)
                     /aSDomain="PKS_KR"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg69_11_PKS_KR.1"
                     /evalue="1.30E-16"
                     /label="ctg69_11_PKS_KR.1"
                     /locus_tag="ctg69_11"
                     /protein_end="169"
                     /protein_start="3"
                     /score="52.9"
                     /specificity="KR activity: inactive"
                     /specificity="KR stereochemistry: C2"
                     /tool="antismash"
                     /translation="ALVTGGSRGIGRAVSCKLAEMGYFILINYQSNDAEAEKTLQLVQE
                     KGSNGEIMKFDVTDPAAIALALNNWASQHPDEYIEVLINNAGIRKDNLMLWMTGEEWNK
                     VLDISLNGFFYVTQPLLKNMLVKRYGRIVNIVSLSGIQGMPGQANYSAAKGGVIAATKA
                     LAQ"
     CDS_motif       complement(8831..8893)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ctg69_11_0001"
                     /evalue="2.90E-04"
                     /label="PKSI-KR_m1"
                     /locus_tag="ctg69_11"
                     /protein_end="25"
                     /protein_start="4"
                     /score="13.5"
                     /tool="antismash"
                     /translation="LVTGGSRGIGRAVSCKLAEMG"
ORIGIN
        1 gaataaaagg agtaggattc agcatccgct cttcattatc taacaggttg ttcagaaact
       61 tttccgtatc aaccaggcag cccagccctg tggctgtgat aattccccct atcttctcgg
      121 gagatagttc gcccatacat tccaatccgc aagccactcc cattttcaca atacggctca
      181 tgcgcctgcg caaagttgca ttggcaataa tatccttata atcgggttca caagcctgaa
      241 gaaaaggacg gtttgctgca acatcgagcg aatcatttac tttcggatta ttttcttgtg
      301 aatgatttcc ttgtggatgg atagaagcga tgcgttgaat ataaactggc tgcataggct
      361 caaaaactta aaggttcgtt cgtttgggaa aattcgttgc ggaaaagagg agcgacgagt
      421 cgtttcctcc gaagccgaaa gaattggata atacatggcg gatcggcact ccttcctgga
      481 aagatgtttc cggtatcaat cctgtttctg attttactcc tgtttctgac aacagttctg
      541 tttccggcat aggctccgtg aaattcagat tcggataaat catgccttta tctatggaaa
      601 gaacggaata aacagcttca attccttcgg aagctcctaa agtgtgtccg ataaaagctt
      661 ttaccgaact aaacggtgga acatgttctc cgaagattct tcgtagtgcc attccttccg
      721 atgcgtcatt accgggagta cctgtcccat gtacgttgat ataatcaata tcttcaggag
      781 aaatgccact ggaagcgatg gcttcactca ttgatagaaa ggcgccatct ccttcgggag
      841 aacttcctgt ttgatgataa gcttcatttg tattagcata accgcttagt tcacagtaag
      901 gaactctttg gagtgaactt tctgattgaa gcactaaata acccgcgcct tctcccaaat
      961 ttaatccgga acgtgaacgg tcaaaaggac gacaatgtat tttgtccaaa atcatgagag
     1021 agttgaaccc attgagcgta aaccggcaaa gtgcatccgt acctccgacg ataacagcat
     1081 tcagttgtcc atgtttaatc agtctcgctc ccaacataat agcattggct gccgatgaac
     1141 aggctgtact gatggtggtt ataaaatcat tgatacctaa atacgaagct attaattcgg
     1201 tactggctcc gcagtcgtgt gaaatcactt cccgcaatcg tccctgtttc gggtttttct
     1261 tgaaagattc atagaaacgc tcgcttaaat ccataccgcc gacagaggtg gcggaaataa
     1321 aaccaatacg taacggttgc tggtcttttt gcgaggttac tgactgattt ggtaattgat
     1381 tttttggctg attggatgat atacgcaagt ttagtcctgc atcttccatc gcttctttgg
     1441 cggctatcat gcctagcaat gctgtgcgtg atactgtacg ctgcggaggt aaagataata
     1501 gttgtttaag ttcttcattg ctacgtttca cttcagatac gggtacatcg agagcagtcg
     1561 ggaaaagagt tacctttccg ataccatgct ttccttgttg tagtgcctct atattttcgg
     1621 aaactccgat gccgatgccc gaaacaactc ccaatccggt gacgtaaatc ttcataagtt
     1681 aagctttccg attagcaatg atgtagtcag tcagtgtaca taccgagtag aagatttgtt
     1741 ttccttcact aggattctct attttaatgc catattcacg ttccaaaatc aggatgattt
     1801 cgagtgcgtc aatggagtca aggccaagac cttcgtcgcc aaacagaggg gcttcatcgt
     1861 caatatcttc cggagtgatt tcttcaaggt tcaactcttc gattagttta cctttcactt
     1921 cgtccatcag ttctcttttg gtttgatcta aattattcat aaatcgttga tatattatta
     1981 agttgtttaa attctgcttg ataatgtccg tccagtagtt cgcaccagcc tatgatgcat
     2041 gtgcgtaact tacctttcgc catcacaatt cttgcgtaat cctctaagga agcagtgtcg
     2101 gattgctgac agacaaagaa tgtattttct ccctgaattt tgtgtcgtat acagatttct
     2161 cccaatacta cattggggag agtgtagaca aatacggcag gactggcggc tttgtctcct
     2221 tctttattga tgatagcttg atgtctgcag tccgtatcca aagaggcgga agcattggct
     2281 agaatgattc caatctcttc tggacggtag ttggtatctt tcaataaata tccggcagct
     2341 acatatccaa gcttacaaag attatccatc ttgtagaact tcatattgtt ttctcccaga
     2401 tgcttgtatg cttcccggat aaacggcgca aagtcagtct ccgaagaatt gaatatagct
     2461 gttccttggt tttctaccac tcccggtttg atcgtgactg tattggctga ttctacggca
     2521 gctttacagg atgccaaaga atcagttttc tgtttcaaat gagcatctgg gagagataat
     2581 accagtgcag cattacagcc tccgaaaccg gaagcggttt tgatacagca tttcattggc
     2641 atcggctgat gagtgctata aacgatgata ggcatgggaa cacccagtgt ctcatatcct
     2701 aaagttccgt agtatattcc ttcttttagt tgctctatgc aaagtatggt ttcaataatg
     2761 cctgaagctc ctaatgtatg cccgaaataa ggcttaagac tatttaccgg aactgcagac
     2821 aatcctgcca aatgtatggc tttggattcc atttcgtcat tataaaccgt agctgttccg
     2881 tgtgcattga taaagctgat atcttcagga agtgctccgg cttcttccat tgcctgattg
     2941 atagccagcg ccagtccgtc tcctgtccgg gaaggaccgg atatatggtt ggcatcattg
     3001 ctgatcgctc ctccggatag aataatatga tttgcgtttc cttgagtttc taaaagcaca
     3061 gctccacagg cttcgcctag acttaatccg tcccgttgta tatcgtatgg ccggcatcgg
     3121 tgtgcgctga ctgaccggaa agacaagaaa ccgctggtaa taaaatgaga aagaatatcc
     3181 ccgccggcga caatcacccg tttgtaacgc cctgattcta tccatctctt ggcaacaacc
     3241 agtgccgaga ctccagatat acaggcgttg gagataactt ctacctgatt ggctgcctca
     3301 aaaaaatgcc cgattcgttc tgccattttc caaagaaaag tcggactatc ggctgataat
     3361 tcctgtaaaa aggaaggatt atcaattgtt gattgtacag aaccgcttgg cttgtccgaa
     3421 ttagttcttt tttcttgatt gctcaataaa tcaatatttc ccttcgtagt agagagcaac
     3481 aaagcacagt ccgactcttg cagattcact cccgattggg aaatcacttc ctgaatagtc
     3541 aatataaaca gttgctctaa ccgggtataa gaggaaatat ccagctcctt tgcccgcttt
     3601 tctaatagtt ctttagctct cttttccaac tcgacagaat caatcatccc tgccagaatc
     3661 ggactgtcag aaatccgtcc ggcttcctgc atacgaatcc cgcttcgata gtcatggatt
     3721 gcttttttgt tttccgaaat accgaaacct aacgaactaa tcagcgtatg ggctgtgatg
     3781 tatatattta aaggatattc catttctttt tccattccag ataaaacgga ggattgataa
     3841 gctccagttc tttattcagg ttcaggaaca cttgtatggt gcttccggtg gccactacac
     3901 tctggtcggt agcccggtag ataacgtatt cgaattttat cttggctgcc tcacaggcaa
     3961 tatagcgtgt ttcgataatc gcttcttcac caaaggacaa tgattgcttg aactggcagg
     4021 ttaaatctac gatgggaacc atgtagcctt cccggtaaat gctcatataa tccaaaccat
     4081 actgtttgcc gaaagcttcc cgcccatctt caaagtagcg cacgtactcg ccatgccata
     4141 caatctgcat ggagtcaatt tcgctgaacc gtactctgaa agtagtccgg ttagtcaaag
     4201 ctgcaatctg ttgatttgtt ttccgtttca ttcttttttg ataaatattt tcatcttaca
     4261 ttcagcaatc agctcttctt ccgttttcac ttgtgccgaa ataagcgtaa tatcgaatac
     4321 ctcttgtacg acggtaatct ctgtaaataa tttcattccg gcttccggca aattgtagat
     4381 tttaagtttg tctaccgaac cgataaaacc taacggaact ttttcaccct gccgggtata
     4441 aataaacccg atacgtgcag ccgctgattg tgcgatatgc tcaataattc ccggctcttg
     4501 cagtctgcct gcctcacaaa ataaattgtc ggtagtgaca gtcagtccgg aatatgaacg
     4561 gttttcttca aatccgaaga aactgtccac cataacgatt ggcggacgct gtggaatcag
     4621 gttgagtatt ccttctcctt gtatgacggc ttctctgttc atttcaatct gcattgtacg
     4681 atgctgtgtc ccattcctaa atggtcatgt atctcttcga tttccaatcc tgctgcttcg
     4741 atgcatcgtt gcatatcgtc cgaatgatac atcttgctgt ttccgtttgc catcgctgta
     4801 aaatagagac tgatttgtgt caggcaataa gcggctgtgt caaatttctg tcggttccag
     4861 aaagtctcca taatatacag gcggctctct cggttcatag aacgggctgc acgggtcaat
     4921 atgctggtaa cttcttcttc cgagaaacaa tcgaggaact ggctcatcca aatagcatcg
     4981 aaccttgtcg ggaaaggcac ctccggatca agcagattgg caccatgacc gtggatacgt
     5041 gtagctccgg gcagctcttt ggtttgttga cgcatcatct ccaattgttg cggaagatcc
     5101 atgatggtta cttccactgt gtcgtcgtag cttacgcatt tggtcgccca gcggccggta
     5161 ttgcctccca catccaataa agtcttggga tggcgggcga agacaattgc cagtgcttca
     5221 tcgaacgaac aatccgagta ataatgatcg aaaccgaacc agctcttttg tacttgtgaa
     5281 ggcagacttg acaacccttc atagatagta ctccattcac cgaatacttt cagtccttca
     5341 ggacgtccgt tggtgatggc ttcttccaga tgaaacattc cctgatagtt gacatcatgg
     5401 ttgaagtcca tattgacacg taccattttg tcattgagca gaaaccagcc ggctttcgca
     5461 aggcagtatc gcccttcacg caacaatacg gtgccgatag tcaatgatgc ctccaacaat
     5521 acttgtgcgc cataagaggg cagcccacaa gctttgctga tttcttcttg cgtcatacct
     5581 ttgcgctcgt cggccaataa ctggaaaatt ccgaatttaa gcataaggcg tgatacctga
     5641 aaaacaatag gcccaaaagc tatttcttgt gccaggcgtt gtgcctctac cgctgtcaac
     5701 ggctctttgt catatttatt ctgttgcatc tttttgtttc tcttttaaat ccggtgactg
     5761 ctttccggca ggttcccaga atggataata attgaaccat tgttccggat agcgttttag
     5821 tatctgttcc aaagcaacag tatattgttc gagcagagcc atctccgctt tcttttcttt
     5881 tgttcgtact accggttccg ctattataaa atgaaaacgg taagttcttc ccggttccct
     5941 cattgcaaag tagaatacca ccggaacttt cattcgcgaa gcgagcagga aaggaccggc
     6001 aggaaaagga gctttctgtc ccagtaaaat tcctggcaga agtttctctt tgttcagata
     6061 acggtcgcct tggaaacata catattcttt ttggttgatc gcctcggtta tgcggaaaac
     6121 gtgtgtcagg ttgtcttcat tgacagggat aatcttaaat tccctgtcct gaccgttttt
     6181 ctccaggatc tctttgattc tacgatgttc ggcatcgtac atcacgatat tgattttctt
     6241 tccgtaatca tcaaagaaag gaacgcctat ttcccagttt cccacatggg cgccaatcat
     6301 aatcactccc tgttcactgt tcagcagttg cagaaactcc ggatactgct cgaatttgaa
     6361 ctgatattga tttacttttc cattaccgat ggctaccttg tcaatcagga tttgtcctaa
     6421 tcggtaatag ttgagtagta acattttcaa agaacgtatc ctattgtatt tcagaatgtg
     6481 acgggcataa aaccaggtgc ttttggttgc tttcggagca aacggtatga agtagagcac
     6541 taccaggctt agaaaaagat aagcggcagt aatgcccaga tacttaatca ggtaaataaa
     6601 gaataagtat ccgaacgttc ctccccgggt tttgcctttc cacgtcgaca tatttacttg
     6661 gcttcctgca tacgggtgat aacgagatcg tagaagtcct ggaaggtttt gatacctgca
     6721 aagtcttgtc cggttacgtt gaaaccgaaa ttcttttcta ccagtaccac catgtcgacc
     6781 aagtccagac tgtccagttc aagagtttcc attaacggcg catccggctg gatgacgtcg
     6841 atgtctactt caaactcttc tgccagagtt gttcttattt tctcgatgat ttcttcgttt
     6901 gtcatatatc tgttttcttt agtaatttat tctttgattt ggcgtataat cagggtggaa
     6961 ttggttcctc cgaatccaaa cgagttggaa aggaacgtat caaattccag atttacccgt
     7021 tgggtaggta tattcaactg tgcggaagcc tcgtccgctt cctcgaaatt gaggttggga
     7081 gcgatgaaac cgttattcat catgaggatg gagtaaatca cttcactggc acctgccatc
     7141 cacatttcat gtccggtcat agacttcgtg gaagtgacat acgggtgatg tccttcaaat
     7201 acttccgcaa tggctttcgc ttcgttcagg tcgcctaccg gagtggaagt ggcgtgtgcg
     7261 ttgatataac tgatttgttc gagtgcaata cccgcatctt tgatggccat ctgaagagaa
     7321 cgtttcggac cgtccacgtt cggtacggag atatgatctc cattggaaga gaaaccgtaa
     7381 ccgataactt cggccaaaat gggagctccc ctttttactg ccgattcata gctctctaat
     7441 accagactgg cggctcctcc actcggaatc agtccgtcac gtcgtttatc aaaaggtttg
     7501 gaggctttct cgggctctgc ttcctgggtg gaaaatgcgc ttagcccgtc gaaactgccg
     7561 accgcataag gatttacttc ttgtgcgcca ccgcaaagaa tacaatcctg caatcctgat
     7621 ttaatgagca gataccccat gccaatagca tgagaaccac ttgcacaagc tccggcaatg
     7681 gtgaagttaa ctcctctaag cttgaagata accgacaggt tcattgtcac ggtagaattc
     7741 atcgactgga aaatagaacc ggaacctacc aacgctgtgt ttttcttttc acgaatgatg
     7801 tccactgcgt tgatgacagg ggcagcacta ctatcattgc catacaagat acccacttca
     7861 ttagcttcga gaaaagcatc gtcaataccg gcgttgcgga aagcctccaa agtagcgaga
     7921 taagcatact ctccctgttc cggcaggcag agacgtttac gacgatctaa tagtttcttc
     7981 aagtcgggac gttccaatat gcccgttaat gcagaaaaat agcccagttc tttccgtacc
     8041 ggatctatgc caatccccga tttcccattg tatagtgagt cttttacttc atccaggttc
     8101 ttgccgatgc aagagtaaat tcccattccc gtgataacaa ctcttttcat tattttgtct
     8161 attctatgct tttgttttaa gtatatagtc ctccgttgat ggaaatcacc tctcctgtga
     8221 tataggatga ggccggagat gccagaaaac cgacgagatc ggcaacctct tccgcagtac
     8281 cgaaacgtcc tgcaggaatg tgttttttcc attcgttctc atcaatccct tccgtcatat
     8341 ccgtgcggat aaatccagga gcaactgcgt tgactgttac ctttttcttg gccacttctt
     8401 gtgccagtgc tttggtagca gctattacgc cacctttggc tgcggaataa ttggcttgtc
     8461 cgggcattcc ctgaatacct gacaaggata cgatattgac aatacgtcca taacgtttga
     8521 ccagcatatt cttcaataaa ggttgtgtca cataaaagaa tccgttcaga ctgatatcga
     8581 gcactttgtt ccattcttct cctgtcatcc aaagcatcag gttgtctttg cggatgcccg
     8641 cattgttaat cagtacttcg atgtattcgt caggatgttg tgacgcccag ttgttcaagg
     8701 caagggcaat agcggcaggg tctgtcacat cgaacttcat gatttctccg ttacttcctt
     8761 tttcctgcac taactgcaac gttttttccg cttctgcgtc gttactctga taattaatca
     8821 gtataaagta gcccatttcc gccagtttgc aactgacagc acggccgata cctcgacttc
     8881 ctccggttac taatgcgtat ttcattttat ttattttctt ttttgagata gtcc
//
