LOCUS       c00536_gnlPro..        15150 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|ONGKLIMM_536.
ACCESSION   c00536_gnlPro..
VERSION     c00536_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-06 01:43:47
            Original ID  :: gnl|Prokka|ONGKLIMM_536
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 15150
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..15150
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[290:5150]"
                     /cutoff="10000"
                     /detection_rule="(TPP_enzyme_C and (minimum(2, [ACD1_car,
                     ACP_syn_III_C, AcetylCoA_hyd_C, AcetylCoA_hydro,
                     Acyl-CoA_dh_1, Acyl-CoA_dh_2, Butyrate_kinase,
                     CT_Propionyl_CoA1, CT_Propionyl_CoA2, CT_Propionyl_CoA3,
                     Carboxyl_trans, CoA_trans, CoA_trans_230_acto,
                     CoA_trans_2_CAF, CoA_trans_6_Glutaconate, E1_dh, ECH_1,
                     ECH_2, HBT, HBT_2, HCDH, HpaB, Ketoacyl-synt_C, Thiolase_C,
                     Thiolase_N, adh_short, adh_short_C2]) or FA_synthesis) and
                     not (PFL-like or PFL_6_pcresol or PFL_9_tma or Gly_radical
                     or Gly_430_pcre or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and not
                     (POR or POR_N))"
                     /neighbourhood="10000"
                     /product="TPP_fatty_acids"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      291..5150
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(TPP_enzyme_C and (minimum(2, [ACD1_car,
                     ACP_syn_III_C, AcetylCoA_hyd_C, AcetylCoA_hydro,
                     Acyl-CoA_dh_1, Acyl-CoA_dh_2, Butyrate_kinase,
                     CT_Propionyl_CoA1, CT_Propionyl_CoA2, CT_Propionyl_CoA3,
                     Carboxyl_trans, CoA_trans, CoA_trans_230_acto,
                     CoA_trans_2_CAF, CoA_trans_6_Glutaconate, E1_dh, ECH_1,
                     ECH_2, HBT, HBT_2, HCDH, HpaB, Ketoacyl-synt_C, Thiolase_C,
                     Thiolase_N, adh_short, adh_short_C2]) or FA_synthesis) and
                     not (PFL-like or PFL_6_pcresol or PFL_9_tma or Gly_radical
                     or Gly_430_pcre or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and not
                     (POR or POR_N))"
                     /neighbourhood="10000"
                     /product="TPP_fatty_acids"
                     /protocluster_number="1"
     cand_cluster    1..15150
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(TPP_enzyme_C and (minimum(2, [ACD1_car,
                     ACP_syn_III_C, AcetylCoA_hyd_C, AcetylCoA_hydro,
                     Acyl-CoA_dh_1, Acyl-CoA_dh_2, Butyrate_kinase,
                     CT_Propionyl_CoA1, CT_Propionyl_CoA2, CT_Propionyl_CoA3,
                     Carboxyl_trans, CoA_trans, CoA_trans_230_acto,
                     CoA_trans_2_CAF, CoA_trans_6_Glutaconate, E1_dh, ECH_1,
                     ECH_2, HBT, HBT_2, HCDH, HpaB, Ketoacyl-synt_C, Thiolase_C,
                     Thiolase_N, adh_short, adh_short_C2]) or FA_synthesis) and
                     not (PFL-like or PFL_6_pcresol or PFL_9_tma or Gly_radical
                     or Gly_430_pcre or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and not
                     (POR or POR_N))"
                     /kind="single"
                     /product="TPP_fatty_acids"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..15150
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="TPP_fatty_acids"
                     /region_number="1"
                     /rules="(TPP_enzyme_C and (minimum(2, [ACD1_car,
                     ACP_syn_III_C, AcetylCoA_hyd_C, AcetylCoA_hydro,
                     Acyl-CoA_dh_1, Acyl-CoA_dh_2, Butyrate_kinase,
                     CT_Propionyl_CoA1, CT_Propionyl_CoA2, CT_Propionyl_CoA3,
                     Carboxyl_trans, CoA_trans, CoA_trans_230_acto,
                     CoA_trans_2_CAF, CoA_trans_6_Glutaconate, E1_dh, ECH_1,
                     ECH_2, HBT, HBT_2, HCDH, HpaB, Ketoacyl-synt_C, Thiolase_C,
                     Thiolase_N, adh_short, adh_short_C2]) or FA_synthesis) and
                     not (PFL-like or PFL_6_pcresol or PFL_9_tma or Gly_radical
                     or Gly_430_pcre or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and not
                     (POR or POR_N))"
                     /tool="gutsmash"
     CDS             complement(291..1115)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_fatty_acids: ECH_1"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg536_1"
                     /sec_met_domain="ECH_1 (E-value: 1.6e-82, bitscore: 266.7,
                     seeds: 9, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSTQREWTTIREYDDILFDYYNGIARITINRERYRNAFTPTTTAE
                     MSDALRICREEADIDVIVITGAGDKAFCSGGDQNVKGRGGYIGKDGVPRLSVLDVQKQI
                     RSIPKPVIAAVNGFAIGGGHVLHVVCDLSIASENAIFGQTGPRVGSFDAGFGASYLARV
                     VGQKKAREIWFLCRKYNAQEALDMGLVNKVVPLEQLEDEYVQWAEEMMLLSPLALRMIK
                     AGLNAELDGQAGIQELAGDATLLYYLTDEAQEGKNAFLEKRKPNFKQYPKFP"
     CDS             complement(1119..2786)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_fatty_acids: TPP_enzyme_C"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg536_2"
                     /sec_met_domain="TPP_enzyme_C (E-value: 1.6e-07, bitscore:
                     21.5, seeds: 323, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MYTDKKNILQLVALLEAHGITKVVLCPGSRNTPIVHTLSNHPNFT
                     CYPVTDERSAGYFAIGLALNGGKPAAVCCTSGTALLNLHPAVAEAFYQNVPLVIISADR
                     PAAWIGQMDGQTVPQPGVFQTLVKKSVNLPEIHTEEDEWYCNRLVNEALLETNHHGKGP
                     VHINIPISEPLFQFTVDSLPEVRVITRYQGLNVYDRDYNDLVDRMNKYQKRMIIIGQMN
                     LIYLFEKRYIKLLYKHFAWLTEHIGNQTVPGIPVKNFDAALYAMPEEKVDQMVPELLIT
                     YGGHVVSKRLKKLLRQHPPKEHWHVSPDGEVVDLYGSLTTVIEMDPFEFLEKIASLLDN
                     RTPEYPRVWENYCKIIPEPEFAYSEMSAVGTLLKALPESCALHLANSSVVRYAQLYSIP
                     STIEVCCNRGTNGIEGSLSTAVGYAAASDKLNFIAIGDLSFFYDMNALWNVNVRSNLRV
                     LLLNNGGGEIFHTLPGLDMSGTSHKFIAAVHKTSAKGWAEERGFLYLQAQNDEELAEAM
                     KTFTQPEAMEQPVLLEVFTNKNKDARMLKNYYHQLKQK"
     CDS             complement(2806..3921)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Chorismate_bind"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg536_3"
                     /sec_met_domain="Chorismate_bind (E-value: 4.9e-57,
                     bitscore: 183.6, seeds: 119, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTDEEISNLTTIDAFIQRKQPFAVYRIPGEKVPRLLTQAEGVVRL
                     IYDLKELNGQRGFVIAPFQVNESCPVVLIQPDQWGQPLPVDDDTEEDREIALRLQGQES
                     FLTSSTEEYTACFHTFINALRDRTFDKLVLSRHLTVDKVADFSPSSIFRAACKRYIHSY
                     IYLCYTPQTGIWLGSTPEIILSGEKDEWHTVALAGTQPLQDGRLPQVWDEKNRKEQDYV
                     SSYIRRQLLSLDIHATENGPYPAYAGALSHLKTDFRFALKDNKGLGDLLKVLHPTPAVC
                     GLPKEEAYQFILQNEGYDRRYYSGFIGWLDPEGRTDLYVNLRCMHIEDKQLTLYAGGGL
                     LASSELNDEWLETEKKLQTIKRLIAVPPLKS"
     CDS             complement(3918..5150)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_fatty_acids: HBT"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg536_4"
                     /sec_met_domain="HBT (E-value: 2.7e-18, bitscore: 56.5,
                     seeds: 132, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKYKLLVLDVDGTLLNDAKEISKRTLAALLKVQQMGVRIVLASGR
                     PTYGLMPLAKMLELGNYGGFILSYNGCQIINAQNGEILFERRINPEMLPYLEKKARKNG
                     FALFTYHDDTIITDSPENEHIQNEARLNNLQIIKEEEFSAAVDFAPCKCMLVSDDEEAL
                     VGLEDHWKRRLNGALDVFRSEPYFLEVVPCAIDKANSLGALLEVLDVKREEVIAVGDGV
                     CDVTMIQLAGLGVAMGHSQDSVKACADYVTASNEEDGVAVAVEKAIIAEVRAAEIPLDQ
                     LNAQARHALMGNLGIQYTYADEDRVEATMPVDHRTRQPFGILHGGATLALAETVAGLGS
                     MILCQPDEIVVGMQVSGNHISSAHEGDTVRAVGTVVHKGRSSHVWNVDVFTSTNKLVSS
                     IRVVNSVMKKR"
     CDS             complement(5235..5597)
                     /locus_tag="ctg536_5"
                     /transl_table=11
                     /translation="MIQVRIKRVYEDFSETDGYRVLVDKLWPRGMKKEWLKYDYWAKDI
                     TPSSTLRRWFHEDIPGHWEDFVIQYQKELDASPSMADFLTLIKPHPVITLLYASKEPVY
                     NHARILRDYLEMRLKE"
     CDS             complement(5663..7420)
                     /locus_tag="ctg536_6"
                     /transl_table=11
                     /translation="MRFFVCILVLLFVHNQFSRADKTLIDDSLYTEKYIRNIYIPEPRR
                     ALQLLDEAENRKTIPLRVVNELRSLSYSNMYMNKLAFMYARKAYLLDSLYQKDPKHMLK
                     MTVHLAEFSAMMSKYNESMRYALDGIRQAQELGNREAKARLFFCMGENNWRLSFKDKAY
                     DYFNRTIELLRGSKEKREMMLLSYYYGAEMSFLMNDSRIEEALKVGFEREKQIERLKAV
                     PQISEDYIDGQYSYLYAKLAYIYCMEKKYEKAEQYYQKYLSKKESHTPDGKMYSVPYLV
                     LSGQYEKVIDNCRGFKELMRTQQDTLNEQYLTVLRQEVKAYLGMHKYKEAAEIRETILT
                     ITDSINTRDRNNAALELNAMYGVSEKEEYIAEQAFQLKIRNITLCFLACIVVLTLFVVW
                     RLWHFNHIVEYKNRMLARLINEKFANRKDGNQLSEVYEQLAVVSEVEPERISPEELEEL
                     ANDTDKESGEEEENKKIFQELNDIVIQKQLYLSSELSREDLAQIVHLNNARFARMIREC
                     TGTNFNGYINELRINYAIELMKKHPNYTIRAIADEAGFNSTPILYNLFKKKTGMTPYEF
                     KKAQDSLQN"
     CDS             complement(7575..8342)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Acetyltransf_1"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg536_7"
                     /sec_met_domain="Acetyltransf_1 (E-value: 1.1e-07,
                     bitscore: 22.4, seeds: 223, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="METNYITLTKENIADEHICCAFSDKKCKDSYELKKAWLKKEFDNG
                     YVFRRIDERAKVFIEYGPAEKAWVPVSAPNYLMINCFWVSGKYKGCGHGKALLQSAIDD
                     AKLQGKDGLVTVVGTSKFHFMSDTKWLLRQGFQTIEKLPYGFSLLALKINPAAPDPSFN
                     DSVLTGECPDRDGIVVYYTHRCPFTEFHVRGSLVNAAKSKDLPLKIIELETMEQAQNAP
                     TPATIFTLFYNGKFVTTDLSACIEARLGKALGL"
     CDS             complement(8392..9327)
                     /locus_tag="ctg536_8"
                     /transl_table=11
                     /translation="MAQKGELHIRNKHNGQYDFPLLIEKYPPLKRFVSLNPLGVQTINF
                     FNPQAVKALNKALLISYYGIRYWDIPKQYLCPPIPGRADYIHYIADLIQPDRVANDLQT
                     EEEDANEQKTKCRCLDVGVGANCIYPIIGHTEYGWTFVGSDIDPVSIENARKIVTCNPV
                     LAHKIDLRLQKDSQKIFDGIIMPGEYFDVTICNPPFHSSKEEAEDGTLRKLSSLKGTKV
                     KKVQLNFGGSANELWCEGGEIRFILNMISESQKYQKNCGWFTSLVSKEKNLEKLCAKLK
                     SVNASEYKIIRMQQGTKSSRILAWRFSNNS"
     CDS             9491..9706
                     /locus_tag="ctg536_9"
                     /transl_table=11
                     /translation="MLKSGETGIRTPGTSQYNGFQDRRNRPLCHLSKTSLSEVLSVESG
                     AKVRIIFKSANILIIFSRINRIFAVH"
     CDS             9720..12221
                     /locus_tag="ctg536_10"
                     /transl_table=11
                     /translation="MIYPQNFEQKIGFDQIRQLLKDKCLSTLGEERVTDMTFSEQHEEV
                     EEKLNQVTEFIRIIQEEDGFPDQFFFDVRPSLKRVRIEGMYLDEQELFDLRRSLETIRD
                     IVRFLHRNEDEEENDTPYPSLKRLAGDIAVFPQLIGKIDGILNKYGKIKDNASTELARI
                     RRELASTMGNISRSLNSILRSAQSEGYVDKDVAPTMRDGRLVIPVAPGLKRKIKGIVHD
                     ESASGKTVFIEPAEVVEANNRIRELEGDERREIIRILTEFSNILRPSIPEILQSYEFLA
                     EIDFIRAKSYFAIQTNSLKPAVENEQLLDWTMAVHPLLQLSLAKHGKKVVPLDIELNQK
                     QRILIISGPNAGGKSVCLKTVGLLQYMLQCGMLIPLHERSHAGIFSSIFIDIGDEQSIE
                     DDLSTYSSHLTNMKIMMKSCNERSLILIDEFGGGTEPQIGGAIAEAVLKRFNQKGTFGV
                     ITTHYQNLKHFAEDHEGVVNGAMLYDRHLMQALFQLQIGNPGSSFAVEIARKIGLPEDV
                     IADASEIVGSEYINADKYLQDIVRDKRYWEGKRQTIRQREKHMEETIARYQTEMEELQK
                     SRKEIIRQAKEEAERMLQESNARIENTIRTIKEAQAEKEKTRQARQELTDFRTSLDALA
                     SKEHEEKIAQKMKKLKEKQERKKNKKNEPKATASSPSSAPKVVPIAVGENVKIKGQTSV
                     GQVMEINGKNATVAFGSIKTTVKIDRLERTNNAPKTEGIAKSTFVSSQTHDQMYEKKLS
                     FKQDIDVRGMRGDEALQAVTYFIDDAILVGMDRVRILHGTGTGILRTLIRQYLATVPGV
                     SHYADEHVQFGGAGITVVDFD"
     CDS             12308..13360
                     /locus_tag="ctg536_11"
                     /transl_table=11
                     /translation="MKNNLLSEKLIYTGDSLTPTHLHLCTYNATEMQESANDTFQAIKG
                     TLNSDRINWLQIHGMKDTETIREICSHFEIDFLVLQDILNADHPTKIEEHDKYIVLILK
                     IFYPNEHKEEDELDELLQQQVCLILGNNYVLTFLEKETDFFDDVSSALRNDVLKIRSRQ
                     TDYLLSVLLNSIMGNYISTISSIDDALEDLEEELLTITSGDDIGIQIQALRRQYMLMKK
                     SILPLKEQYIKLLRAENLLIHKVNRAFFNDVNDHLQFVLQTIEICRETLSSLVDLYISN
                     NDLRMNDIMKRLTIVSTIFIPLTFLVGVWGMNYKWMPELEWQYGYLFAWIVMAIIGIIV
                     YLYFRKKKWY"
     CDS             13380..14588
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) SDH_alpha"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) SDH_beta"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg536_12"
                     /sec_met_domain="SDH_alpha (E-value: 9e-84, bitscore:
                     271.4, seeds: 645, tool: rule-based-clusters)"
                     /sec_met_domain="SDH_beta (E-value: 1.7e-22, bitscore:
                     70.7, seeds: 368, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKSIKELYRIGTGPSSSHTMGPRKAAEMFLERHPDAASFKVTLYG
                     SLAATGKGHMTDVAIIDTLQPTAPVEIVWQPKVFLPFHPNGMTFAALDNNDKVQENWTV
                     YSIGGGALAENNDNPTIESPDVYGMENMTEILQWCEDTGKSYWEYVKECEEEDIWDYLA
                     EVWATMKDAIHRGLEAEGVLPGPLNLRRKASTYYIRATGYKQSLQSRGLVFSYALAVSE
                     ENASGGKIVTAPTCGSCGVMPAVLYHLQKSRDFSDMRILRALATAGLFGNIVKFNASIS
                     GAEVGCQGEVGVACAMASAAANQLFGGSPAQIEYAAEMGLEHHLGMTCDPVCGLVQIPC
                     IERNAYAAARALDANLYSAFTDGMHRVSFDKVVQVMKQTGHDLPSLYKETSEGGLAKDY
                     KQM"
ORIGIN
        1 agtcaggaga ggtaaaatga agataccaaa ctttacgcgt agtatatgtt cctctggaag
       61 tcccggcagg ttgcttgaaa tggagcaatc ggggaataat ttctatttta caattcatcg
      121 tgaataattt ttcaattcac cacagaataa cacagagcct cacgaagttt taataagtta
      181 tatctcttgc agttctccta ccattctctc ctccacagtc ttgctttgca gaaaatcggg
      241 cttaaacgca ggaaaagcaa actctgtggt actctgtggc aaagccgatt ttaagggaat
      301 ttcggatatt gtttgaagtt cggtttacgt ttctccagaa acgcattctt tccttcctgt
      361 gcttcatcag tcaggtaata gagcaacgtt gcgtcacctg ccaattcctg aatacctgct
      421 tgaccatcca gttcggcatt caatcctgct ttaatcatgc gcaaagccaa cggactaagc
      481 agcatcattt cttctgccca ctgcacatat tcatcttcca actgctccaa aggaactact
      541 ttattcacta atcccatgtc caatgcttct tgtgcattat acttccgaca gaggaaccag
      601 atttcgcgtg ctttcttctg acctaccaca cgtgccagat aagacgcacc gaatccggca
      661 tcaaagctac ctacacgagg acccgtctga ccgaaaatag cattttccga cgcaatggac
      721 aaatcacata ccacatgaag cacatgtccg ccaccaatag caaaaccgtt cacggcagca
      781 atcaccggtt tcgggatgct gcgaatctgc ttttgcacat ccaatacgct tagacgaggc
      841 acaccgtctt ttccgatata tccgccacgt cctttcacat tctggtcgcc acccgaacaa
      901 aacgccttat caccggctcc ggtaatcaca atcacatcaa tatccgcttc ttcacggcag
      961 atgcgcaatg cgtcactcat ttcagcagta gttgtcggag taaacgcatt ccgatagcgc
     1021 tcacggttga tcgtgatacg ggcaattcca ttataataat caaaaagaat atcgtcgtat
     1081 tctctaatgg ttgtccactc tctttgtgtt gacataatct atttttgttt taattgatga
     1141 taataattct tcaacatgcg cgcgtccttg tttttgttgg taaacacctc caagagcaca
     1201 ggctgctcca tagcttccgg ttgagtgaaa gttttcatcg cttcagccag ttcttcgtca
     1261 ttttgcgctt gcagatagag aaacccacgc tcttctgccc aacctttggc cgatgtttta
     1321 tgaactgccg caataaattt atgtgaggta cccgacatat ccaatcccgg caaggtatgg
     1381 aaaatctctc ctcctccatt atttaacaga agaacacgca gattggagcg aacattgacg
     1441 ttccacaacg cattcatatc atagaagaag ctcaaatctc cgatagctat aaagttcagt
     1501 ttgtcggaag ctgccgcata accgacagcc gtagacagcg agccttcaat gccgtttgtt
     1561 ccccggttgc aacaaacttc aatcgtagaa ggaatggagt ataattgcgc atagcgcacc
     1621 accgaactgt tagccagatg caacgcacat gactccggca aggctttcaa caacgtaccg
     1681 acagcagaca tttccgaata agcaaactcc ggttcaggaa tgatcttgca atagttttcc
     1741 cacacacggg gatattcagg agtccgattg tccagcaaac tggctatctt ctccagaaac
     1801 tcgaacgggt ccatttcgat caccgtagtt aatgagccat acaaatcgac cacctcaccg
     1861 tccggcgata cgtgccaatg ttctttaggc ggatgctgac ggagcaactt cttcaatcgt
     1921 ttggaaacga catgtcctcc ataagtaatc agcagctccg gaaccatctg atctaccttc
     1981 tcttcgggca tggcataaag cgccgcatcg aagttcttta ccggaatacc gggaactgtc
     2041 tggttgccga tatgttccgt caaccaggca aaatgtttat ataataactt gatatatctt
     2101 ttttcaaaca gatagataag attcatctga ccgatgataa tcatacgctt ctggtattta
     2161 ttcatccggt cgaccaaatc gttataatca cgatcgtaga cgttcaaccc ctgataacgg
     2221 gttatgacac gcacttctgg aagcgaatcg accgtaaact ggaacaatgg ttcagaaata
     2281 gggatattga tatgtaccgg tccttttcca tgatggttcg tctccagcaa tgcttcattc
     2341 accagacgat tgcaatacca ttcatcttct tccgtatgaa tctccggaag gtttaccgac
     2401 ttcttgacca gcgtctgaaa tacgcctggt tgtggtacag tctgtccgtc catttgtccg
     2461 atccaggcag cgggacggtc tgcagaaata atgaccagag gaacattttg ataaaatgct
     2521 tctgccacag ccggatgaag gtttaataat gcagtaccgg aagtgcagca gacagcagca
     2581 ggcttaccac cattcaacgc aagaccgatg gcaaaatagc cggcactccg ttcatccgtc
     2641 accggatagc aggtaaaatt cggatggtta gacaaagtat gcactatggg ggtgttacga
     2701 ctacccggac acaacacaac cttagtaatc ccatgcgcct caagcaacgc aaccaactgg
     2761 agtatgttct tcttgtctgt atacatgatg ataattatta gtagtttatg attttaaagg
     2821 aggcactgca atcagccgtt tgatggtttg caactttttc tccgtttcca gccattcgtc
     2881 attcagttcc gaagaggcca ataatccacc gccggcataa agagtgagtt gtttatcttc
     2941 gatatgcata cagcgcaggt ttacatacaa gtctgttcgc ccttccggat cgagccatcc
     3001 gataaaaccg gagtaatagc ggcggtcgta accttcgttc tgcaaaataa actgataggc
     3061 ttcttccttc ggcaagccgc atacggcagg tgtcggatgc aaaactttca gaaggtctcc
     3121 caaaccttta ttatctttca aagcgaaccg gaaatcggtt tttaaatgtg acaaagcacc
     3181 ggcataagca ggatatggcc cgttttccgt agcatggata tccagtgaaa gaagctgacg
     3241 acggatataa gaagatacat aatcctgttc cttccggttc ttttcatccc atacttgcgg
     3301 cagtctgcca tcttgcaaag gctgtgttcc ggccagcgca accgtatgcc attcgtcttt
     3361 ctcacccgat aaaatgattt cgggagtgct tcccagccag atccctgtct gcggagtata
     3421 acataagtat atatacgaat gaatataacg tttacaagcc gcccgaaaga tggacgaagg
     3481 agagaaatca gctactttat caactgtaag atgacgggaa agcactagtt tatcaaaagt
     3541 cctgtcacgt aacgcattta taaaggtatg aaagcatgcc gtatattctt ccgtggaaga
     3601 agtcagaaat gattcttgcc cttgcaggcg caaggctatc tcccggtctt cttccgtatc
     3661 atcatccacc ggtaaaggct gcccccactg atcgggttga atcaatacaa ccggacatga
     3721 ctcattcacc tgaaacggag caattacaaa tcctctctgt ccgttcagtt ctttcaaatc
     3781 gtatatcaaa cggaccactc cttccgcctg cgtcaacaga cggggaactt tctctccggg
     3841 aatacggtaa acagcaaacg gctgcttccg ctgaataaat gcatcaatag ttgtcaagtt
     3901 acttatttct tcgtcggtca tctctttttc atcacactgt tgactacccg tatggaagac
     3961 accagtttgt ttgttgaagt aaacacgtct acattccata cgtgggagga acgtccttta
     4021 tgtacaactg ttcctactgc acgcacggta tctccttcat gtgcagaaga tatatggttt
     4081 ccgctgacct gcattcctac tacaatctcg tccggctggc aaagaatcat cgaaccgagt
     4141 ccggcaactg tttccgccaa cgcaagagta gctccaccat gcaaaatacc aaaaggctga
     4201 cgggtacgat ggtctaccgg catcgttgct tccacacgat cttcgtcggc gtatgtatat
     4261 tgaattccca agtttcccat taatgcatgg cgtgcctgcg cattcagttg gtcaagggga
     4321 atttcggctg cacgcacttc ggctataata gccttctcca ctgcaacggc cactccgtct
     4381 tcctcattcg aagcagtcac atagtcggca caggctttca ccgagtcttg tgaatgtccc
     4441 atagctacgc ccagcccggc caactgaatc attgttacgt cacacacacc gtcgcccaca
     4501 gcaatcactt cctcacgctt cacatccagt acctccagca aagcacccaa agagttggct
     4561 ttgtcgatag cgcagggaac tacttccaga aaatatggtt ccgaacggaa tacgtccaac
     4621 gctccgttca atcgtctctt ccagtgatct tccagaccaa ccagtgcttc ttcgtcatcg
     4681 ctcaccagca tacacttaca aggagcaaaa tcaacggcag cagaaaattc ttcttctttg
     4741 attatttgca ggttattcaa ccgggcttca ttttggatat gttcattttc aggagaatcc
     4801 gttatgatcg tatcatcatg ataagtgaat aaggcaaaac cgtttttacg ggctttcttt
     4861 tccagatacg gcaacatttc gggattaatc cgacgttcaa acagaatttc cccgttttgt
     4921 gcattgataa tctgacagcc attataggaa aggataaaac ctccatagtt tccaagttca
     4981 agcatcttgg ccagcggcat caggccataa gtaggtctgc cggatgccag cacaatacgt
     5041 actcccattt gctgaacctt caacagggca gccaatgtac gcttactaat ttctttcgca
     5101 tcattgagga gtgttccgtc tacatcaaga accaataatt tatacttcat gattacacga
     5161 ttttgattta gattacaaag gtaggaaatt gagtgaacga cagaaagcgt aaacagataa
     5221 aaattacttt aatttcactc tttcaaacgc atttccagat aatcgcggag gatacgggca
     5281 tgattataca ccggttcttt ggaagcgtaa agcaatgtta tcaccggatg tggcttgata
     5341 agagtcagaa aatcagccat tgagggagaa gcatctagtt ctttctgata ctgtatgaca
     5401 aagtcttccc agtgtccggg aatatcttcg tgaaaccatc tacgcaatgt ggaagacggt
     5461 gtgatgtctt ttgcccaata atcgtactta agccattctt tcttcattcc acgtggccat
     5521 aatttatcta ccagtacccg gtagccatct gtttctgaaa aatcttcgta aacccgcttt
     5581 atccttacct gtatcatctc tattaatagt taattataaa tagataaacc ggaaaatgcg
     5641 aaaattgttt agcagaatcc actcaattct gtaacgaatc ctgtgctttt ttaaattcgt
     5701 aaggagtcat tcccgtcttt ttcttaaaaa gattgtataa aatcggggtg ctattaaatc
     5761 cggcctcatc tgcaatggca cgtatcgtat agttaggatg ctttttcatc agttcaatgg
     5821 cataattaat gcgcaattca ttgatatatc cattgaaatt ggtcccggta cattctctta
     5881 tcatcctcgc aaaacgtgcg ttattcagat gtacgatttg tgccagatct tctctcgaca
     5941 attctgaaga aagatataac tgtttctgaa taacgatatc attcagttcc tgaaatatct
     6001 tcttattctc ttcttcttcc ccactttctt tatctgtatc gttagcaagt tcttccagtt
     6061 cttcgggtga aatacgttcc ggttcaacct ccgacacaac agccagttgt tcgtatactt
     6121 ccgataactg gttcccatct tttctattag caaatttctc gtttataagc ctggcaagca
     6181 tcctgttctt atactcgact atatgattga aatgccacaa acgccaaacg acaaacagag
     6241 tcagtacaac aatacatgca agaaaacaga gggtaatatt ccttattttt aattgaaaag
     6301 cctgttcggc aatatattct tctttttcag agacgccgta cattgcattc aattccaatg
     6361 cagcattgtt tctatcccgg gtattgatac tatctgttat agttaaaatc gtttcacgta
     6421 tctcggcagc ttctttgtat ttatgcatac ccaaatatgc cttcacttcc tgtcgaagga
     6481 cagtcagata ctgttcattc aaagtatcct gctgggttct catcaattcc ttgaaccccc
     6541 tgcaattatc aataaccttt tcatattgtc cggaaagcac taaataagga accgagtaca
     6601 tttttccgtc gggagtatga gattctttct ttgataagta tttctgataa tattgctccg
     6661 ccttctcata tttcttctcc atgcaataga tgtaggctaa tttggcatat aaataactat
     6721 attgaccgtc tatataatct tcagagattt gaggtactgc cttaagccgt tcaatttgct
     6781 tttcacgctc aaaacccact ttcaatgcct cttcaattcg agaatcattc attaaaaagc
     6841 tcatttctgc tccatagtaa taagagagca acatcatttc ccgcttctcc tttgagcccc
     6901 gcaaaagctc aatagtccgg ttaaaataat cgtatgcttt atctttaaaa gataatctcc
     6961 aattattctc tcccatacag aaaaataacc tggctttggc ttccctgttc cctaactctt
     7021 gcgcctgcct gattccatct aatgcataac gcatactttc attatatttg ctcatcattg
     7081 ccgaaaattc agccaaatgt actgtcattt tcagcatgtg tttcggatct ttttgatata
     7141 gggaatcaag caaataagct ttccttgcat acataaatgc tagtttattc atatacatat
     7201 tactatatga taaactacgc aattcattta caacccgcaa aggaatcgtt ttcctgttct
     7261 ccgcttcgtc cagtaattgc agagcacgcc taggttcggg aatataaata ttcctgatat
     7321 atttctccgt atacagagaa tcatcaatta aagttttatc agccctcgaa aattgattgt
     7381 gtacaaataa aagcaccaaa atacatacaa aaaaacgcat aagatcttac cgtgttttaa
     7441 tcattcagca tccaaagata tgtattttcc acaaaaagtg caaggtgcat cttaattttg
     7501 caaaattaaa ataagaaaca ttagctatct tcttatccca atcctagttt ctgataaatc
     7561 ttcatctcac agaatcacaa gcctaaagcc ttccccaacc gggcttcaat acacgcgctc
     7621 aaatcggttg taacaaactt cccattataa aaaagagtaa agatagtggc tggtgtaggc
     7681 gcattttgtg cttgttccat ggtttctaat tctattattt ttaatgggag atccttactc
     7741 ttggctgcat tgaccaaaga accgcgaaca tggaattcag taaacggaca gcgatgagta
     7801 taatacacta ctattccatc ccggtcagga cactcacctg tcaatacact gtcgttgaat
     7861 gaaggatcgg gagcagccgg atttattttc aaagccaaca aactgaatcc gtaaggaagt
     7921 ttttctatag tttggaaacc ttgtcgcagc agccattttg tatcactcat aaaatgaaat
     7981 ttagaagtgc ccactacggt aactaaacca tcttttccct gcaatttcgc atcatcaata
     8041 gcagactgca gcaaagcctt accatgcccg catcctttat atttacccga tacccagaaa
     8101 caatttatca tcagataatt aggagcactg acaggaaccc acgccttttc agcaggacca
     8161 tattcgatga acacttttgc ccgttcgtca atacgtctga aaacataacc attatcaaac
     8221 tcttttttca gccatgcttt ttttaattca taactatctt tgcatttctt atccgaaaag
     8281 gcacagcata tatgttcgtc cgcaatattc tccttcgtca aagtgatgta atttgtttcc
     8341 ataatattat attaataggt ttaaaaataa cagatcgata agcactcatt attatgagtt
     8401 attagaaaat cgccaagcta atattctgct gcttttagtt ccctgctgca ttctgataat
     8461 cttatactcc gatgcattca cagacttcaa tttagcacat agcttttcaa gattcttttc
     8521 ttttgaaacc aagctggtaa accatccaca gttcttctga tatttctgac tctcggagat
     8581 catattcagt ataaaacgga tttctccacc ctcacaccaa agttcattcg cactcccgcc
     8641 aaaatttaat tgtacttttt tcaccttcgt ccctttcagg ctactcaatt tgcgcaaggt
     8701 tccgtcttcc gcttcttcct tcgagctatg aaacggaggg ttacatatcg taacatcaaa
     8761 atactcgcca ggcatgataa ttccatcaaa aattttctga ctgtctttct gtagtcgcaa
     8821 gtcaatctta tgtgccaata ccgggttgca agtcactatc tttcgtgcat tctcaatcga
     8881 gaccggatca atatcactgc ccacaaatgt ccatccatat tctgtgtgcc ctataatcgg
     8941 ataaatacaa tttgcaccta ccccaacatc cagacatctg catttcgttt tctgttcgtt
     9001 cgcatcttcc tcctctgtct gcaaatcgtt cgctacccta tccggctgaa taagatcggc
     9061 aatataatga atataatccg ctcttccagg aatgggtgga cacaagtatt gtttcggtat
     9121 atcccagtac cgaatgccat aataactgat taataatgct ttatttaaag cttttactgc
     9181 ttgcggatta aaaaagttta tagtttgtac acccagagga ttaagtgata cgaatctctt
     9241 aagtggagga tatttttcta tcaacaacgg aaaatcgtat tgaccattgt gcttatttct
     9301 tatatgtaac tcaccttttt gtgccatgcc ggcaaagata cagagaattt tcctgtctgc
     9361 aaattttccc tgttaataca ctaaattgga atcaaatcac ccaaaaatat cataaaataa
     9421 aaaagcatcc cataaggtca ttttctgata ccttaattag gatgcttatt ctataacgca
     9481 ttgatattca atgcttaaaa gcggagagac agggattcga accccgggta cctcgcagta
     9541 caacggtttt caagaccgcc gcaatcgacc actctgccac ctctccaaaa cttccttatc
     9601 agaagtgctt tccgttgaaa gcggtgcaaa ggtacgaatc atttttaaat ctgcaaacat
     9661 tctgataatt ttttcgcgaa ttaatcgtat ttttgcagtc cattagtaag aacaaagata
     9721 tgatataccc tcaaaatttt gagcaaaaga taggattcga ccagatcaga cagttactaa
     9781 aagataagtg tcttagcact ttaggcgaag aaagagtcac agatatgacc ttttcggagc
     9841 aacatgaaga agttgaggag aaattaaacc aggtaacaga gtttatccgc atcatccagg
     9901 aagaggacgg atttcccgat caatttttct ttgatgtccg cccttcgcta aagcgggtgc
     9961 ggatagaagg aatgtatctg gacgaacaag aactattcga cctgcgccgt tcgttagaaa
    10021 ctatccgcga cattgtacgc tttctccatc ggaatgaaga tgaagaagag aacgataccc
    10081 cctaccccag cctgaaacga ctggcaggag atatagcagt tttccctcaa ctgataggaa
    10141 aaatagacgg tatccttaac aaatatggaa aaatcaagga taatgcttcc accgaattag
    10201 cccgtatacg tcgcgagctt gccagtacga tgggaaatat ttcccgctcg ttaaacagca
    10261 tcctgcgcag cgcacaatcc gaaggatacg tagataaaga cgtagctccc accatgcgtg
    10321 acggacgttt ggtgatcccc gtcgcacccg gactcaagcg aaaaatcaaa ggtattgtac
    10381 acgatgaatc cgccagcgga aaaacagtgt ttatagaacc ggcggaagtc gtagaagcca
    10441 acaaccgtat tcgcgaactc gaaggcgacg aacgacgcga aattattcgc atccttaccg
    10501 agttttcaaa cattctccgt ccgtctatcc cggaaatcct tcaatcatac gaatttctgg
    10561 cagaaataga ttttatccgt gcgaaaagct atttcgccat acagaccaat agtctgaaac
    10621 ccgccgtaga gaatgagcaa ctactggact ggacaatggc tgtgcatcct ttattacaac
    10681 tttcacttgc caaacacgga aagaaagtcg taccactgga tatagaactg aatcaaaaac
    10741 aacgcattct tattatatcc ggtccgaatg ccggaggtaa gtccgtctgc ctcaaaacag
    10801 tcggtttact gcaatatatg ttgcaatgcg gtatgctcat tcccttgcac gaacgcagtc
    10861 acgccggtat attcagcagc atctttatcg atattggtga tgagcaatct attgaagacg
    10921 atttgagtac ctactcttct cacctgacca atatgaaaat catgatgaag agttgcaacg
    10981 agcggagcct catcctgatt gacgagttcg gtggaggtac agaaccgcaa attggaggtg
    11041 ctattgccga agccgttctg aaacgtttca accagaaagg aaccttcgga gtcatcacca
    11101 cccactacca gaatctgaaa cattttgccg aagatcatga aggagtagtg aacggagcca
    11161 tgctttacga ccgccatctc atgcaagcac ttttccagct acaaatcgga aatcccggaa
    11221 gttcgtttgc cgtagaaatc gcacgaaaaa tcggattgcc ggaagatgtc attgcagatg
    11281 cttcggaaat cgtaggaagt gaatatatca atgccgacaa ataccttcag gacatcgtgc
    11341 gcgacaagcg ttactgggaa ggaaaacgtc aaactatccg tcaacgggaa aagcacatgg
    11401 aagaaaccat tgcccgctac caaacggaaa tggaagagtt gcagaaatca cggaaagaga
    11461 tcatccggca agcaaaagaa gaagcggaac ggatgcttca ggaatccaat gcacgcattg
    11521 aaaacacaat acgcacaatc aaggaagcac aagctgaaaa ggaaaagaca cgccaggcac
    11581 gtcaggaact gacagacttc cgtacttctt tagatgcgct ggcttctaaa gagcatgaag
    11641 agaagattgc acagaaaatg aagaaattaa aggagaaaca agaacggaag aaaaataaga
    11701 aaaacgaacc gaaggccaca gcctcttccc catcaagtgc tcctaaagta gtaccgattg
    11761 cagtaggtga aaatgtaaaa atcaaaggac agacaagtgt cggccaagtg atggaaatca
    11821 atggtaaaaa tgcaaccgtt gcttttggga gtataaaaac gaccgtaaaa atagaccgtc
    11881 tggaacgtac caataacgcc cccaagacgg aaggaatcgc caaaagcacc tttgtcagta
    11941 gccagacgca tgatcagatg tacgaaaaga agcttagctt caaacaagac atcgatgtgc
    12001 gtggaatgcg cggagacgaa gctctgcaag cagtcaccta ttttatcgat gacgccatat
    12061 tagtcggcat ggaccgtgta cgcatccttc acggcacagg aacgggaata cttcgtacat
    12121 tgatccgcca gtatctggcc accgtaccgg gagtgagcca ctatgccgac gaacatgtgc
    12181 agtttggcgg tgccggaatc acagtagtcg attttgacta acctgtaaac aaaacgtcca
    12241 aagaacttgt tctcatttag aaaaccacta cctttgttac agtggttttc taaaacgaga
    12301 ataaagcatg aagaataatc tgttaagcga aaagcttatt tacacaggag acagtcttac
    12361 tcctacccac ttacatcttt gtacttacaa tgctaccgag atgcaggaaa gcgccaacga
    12421 cacctttcaa gccatcaagg gaacactgaa cagcgatcgg atcaattggc tacaaataca
    12481 cggaatgaaa gatacggaga ctatccgaga aatttgcagt cattttgaaa tagacttcct
    12541 agtcctgcaa gatatactga atgcggatca tcctaccaag atagaagagc atgacaaata
    12601 catcgtcctg atcttaaaaa tattctaccc caacgaacat aaagaagaag acgaactgga
    12661 cgagttgctc caacagcaag tttgtcttat tctaggtaat aactacgtac ttactttcct
    12721 cgaaaaagaa accgacttct tcgatgatgt cagctccgcc ctgcgtaatg atgtcctgaa
    12781 gatacgcagc cgccagactg attatctact tagcgtgctg ctcaacagca tcatgggaaa
    12841 ctatatttca acaatctctt ccattgatga cgcactcgaa gatttggaag aagaactgct
    12901 caccatcacc agcggtgatg acatcggaat tcagattcag gcattacgac gccaatatat
    12961 gctgatgaaa aaatccatcc ttccactaaa agaacaatat atcaagttac tacgggcaga
    13021 aaacctgctt attcacaaag tgaaccgtgc ctttttcaat gatgtaaacg accacttgca
    13081 atttgtatta cagaccattg agatctgccg ggaaactctt tcctcattag tcgatctgta
    13141 catctccaac aatgatttac gtatgaacga catcatgaag aggttaacca tcgtatccac
    13201 catctttatc cctttgacat ttctggtcgg agtatgggga atgaattaca aatggatgcc
    13261 cgagctcgaa tggcaatacg ggtatttatt tgcctggatt gtaatggcaa ttatcggtat
    13321 tattgtatat ttgtacttca gaaaaaagaa atggtattaa caaaaacaca tcatcagtca
    13381 tgaaatcgat aaaagagcta tatagaatag gcacaggacc ttccagtagc cacactatgg
    13441 gaccgcgcaa agctgccgaa atgtttctgg aacgtcatcc ggatgctgca tcttttaaag
    13501 taacccttta cggcagttta gctgctacag gcaaaggaca catgacggat gtagccatta
    13561 tagacacttt gcaacccact gccccggtag aaattgtgtg gcagcccaaa gtctttctac
    13621 cgttccatcc gaacggaatg acatttgcag ctctggataa caacgataaa gtgcaggaga
    13681 attggactgt ttatagcatc ggtggtggtg cattggcaga aaataatgac aatccaacca
    13741 tcgaaagccc cgatgtatat ggtatggaaa acatgactga aatactccaa tggtgtgaag
    13801 ataccggaaa aagttattgg gaatacgtaa aggaatgtga ggaagaagat atatgggact
    13861 acctggctga agtatgggct accatgaaag atgccattca ccgtggactc gaagcagagg
    13921 gcgtactacc cggaccacta aatctccggc ggaaagcctc cacttactac atacgtgcta
    13981 ccggatacaa acaatccctg caatccagag gactcgtctt ctcttatgct ttagccgtaa
    14041 gtgaagaaaa tgcttccggt ggcaaaatag taaccgctcc tacctgtggc tcctgcggag
    14101 tcatgcctgc cgtactttat catcttcaaa aaagccgtga ctttagcgat atgcgcattt
    14161 tacgtgcgtt agccactgcc ggtttgtttg gcaacatcgt caaattcaac gcatccattt
    14221 ccggagcaga agtaggttgt cagggagaag taggtgttgc ctgcgcaatg gcttcggctg
    14281 ccgccaatca attgttcggg ggcagtcctg cacaaattga gtatgcagca gaaatgggct
    14341 tggagcacca tttgggaatg acttgcgacc cggtatgcgg attggtacaa attccctgca
    14401 tcgaacgaaa tgcatacgcc gccgcacgtg cgctggatgc taatctttat tcagctttca
    14461 ccgatggcat gcaccgtgtc tctttcgaca aagtagtgca agtgatgaaa cagaccggac
    14521 atgacctacc gtcactctat aaagaaacaa gtgaaggagg attggccaag gattacaaac
    14581 aaatgtaatt ataaaaagca acggaccatt ccttttatag aaatagtccg ttgtcatttt
    14641 tatgattaaa atttattcag ttggcggcca attcgtatca tctccgttac tgatatcttt
    14701 ctcatgtatc aatccgccat cctgcgtgaa ataaagcgag tagcgctggc taccttgttt
    14761 cacctgaatc acagattcca tcggattctg tggaaatgtc aacacatata catctgtcac
    14821 tacccacgcg ttatatttag aatctataaa agccgtataa acagccggca ccaactgatc
    14881 gatactgttc agttcatttt ctgtcatcac ccagttggca ttagcatcaa accagacttc
    14941 caattcatca ttgctcaccc aacagtcagc tacataataa gcacctttca tctcccattc
    15001 tatattctgg gcagccggat atacctgttt caaggcctcc gtaatattac tgggcggaac
    15061 aaaagtatca tcatcgtcat tatcacatgc gccgaaagaa agggcagtca taagcaacac
    15121 tactgcccat gcgctaaact taaatctcca
//
