LOCUS       gnlProkkaMCAJOALH_112  15221 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|MCAJOALH_112.
ACCESSION   gnlProkkaMCAJOALH_112
VERSION     gnlProkkaMCAJOALH_112
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2024-11-30 23:38:07
            Original ID  :: gnl|Prokka|MCAJOALH_112
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 44593
            Orig. end    :: 59814
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     CDS             complement(1..666)
                     /locus_tag="ctg112_53"
                     /transl_table=11
                     /translation="MFEIKVSKEIKDACPVFAGAAVYAAVKNTAYSEGLWQEINAFTGQ
                     LTSTTQMEDIKHQPVIFATREAYKRCGKDPGRYRPSAEALRRRLMRGIPLYQIDTLVDL
                     INLVSLRTGHSIGGFDADKIQGTHLELGIGKAGEPFEGIGRGVLNIEGLPVYRDSFGGI
                     GTPTSDHERTKMDLETTHILAIVNGYNGKEGLREAAEMIQTLLRNYTESDGGEIVFFE"
     protocluster    1..15221
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="True"
                     /core_location="[10000:10231]"
                     /cutoff="10000"
                     /detection_rule="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /neighbourhood="10000"
                     /product="RRE-containing"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..10231
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /neighbourhood="10000"
                     /product="RRE-containing"
                     /protocluster_number="1"
     cand_cluster    1..15221
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /kind="single"
                     /product="RRE-containing"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..15221
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="RRE-containing"
                     /region_number="1"
                     /rules="minimum(1, [Bottromycin_Methyltransferase_RRE,
                     Cyanobactin_D_RRE, Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /tool="antismash"
     CDS             complement(717..1529)
                     /locus_tag="ctg112_54"
                     /transl_table=11
                     /translation="MISLTKHNELKGYKSLEAYPEVAHFVTTRHEGISTGAYGSFNCSP
                     YTNDSCMNVNRNQSWLFQCMNHQIKELFIPEQNHGCASLIINESFFKESLEMRRLLLRG
                     MDALITNVPGYCVCVTTADCVPVLLYDKKQHVVAAVHAGWKGTVKHIVSHVMDHLNKMF
                     GTQGEDVIACIGPSISLESFEVGDEVYDAFEESGFDMSLISMKKKETGKYHIDLWEANR
                     IELLNLGVPAEQIEVAGICTYIHHDEFFSARRLGIDSGRTLSGIMIRK"
     CDS             complement(1526..2614)
                     /locus_tag="ctg112_55"
                     /transl_table=11
                     /translation="MRREKYCPNGGPDGGDGGRGGHIILRGNRNYWTLLHLKYDRHAMA
                     GHGESGSKGRSFGKDGADKIIEVPCGTVVYNAETGEYLCDVTEDGQEVVLLKGGRGGQG
                     NWHFKTATRQAPRFAQPGEPMQEMTVIMELKLLADVGLVGFPNAGKSTLLSSISAAKPK
                     IADYPFTTLEPNLGIVSYHGGKSFVMADIPGIIEGASQGKGLGLRFLRHIERNSLLLFM
                     VPADSDDIRKEYEVLLNELRTFNPEMLDKQRVLAVTKSDMLDQELMDEIEPTLPEGIPH
                     VFISSVSGLGISVLKDILWEELNKESNKIEDIVHRPKDVTRLQQELKDMGEDEDIVYEY
                     EEDVDDDDDIDYEYEEEDWEEK"
     CDS             complement(2779..3348)
                     /locus_tag="ctg112_56"
                     /transl_table=11
                     /translation="MLNIVIFGAPGSGKGTQSERIVEKYGINHISTGDVLRAEIKNGTE
                     LGKTAKGYIDQGQLIPDELMIDILASVFDSFKDSKGVIFDGFPRTIAQAEALKKMLAER
                     GQDVSVMVDLDVPEEELMVRLIKRGKDSGRADDNEETIKKRLHVYHSQTAPLIDWYKNE
                     KKYQHINGLGTMEGIFAEICEAVDKL"
     CDS             complement(3408..3944)
                     /locus_tag="ctg112_57"
                     /transl_table=11
                     /translation="MDTIQIKDKLFTVSIKEQEIQKEVIRVANEINRDLAGKNPLFLSV
                     LNGSFMFTADLLKHITIPCEISFVKLASYQGITSTGVIKEVIGLNEDIAGRTIVIVEDI
                     VDTGLTMQRLLETLGTRNPEAIHIASLLVKPEKLKVNLNIEYVAMEIPNDFIVGYGLDY
                     DGFGRNYPDIYTVVD"
     CDS             complement(3985..5529)
                     /gene_functions="transport (smcogs) SMCOG1202:major
                     facilitator transporter (Score: 46.8; E-value: 2.5e-14)"
                     /gene_kind="transport"
                     /locus_tag="ctg112_58"
                     /transl_table=11
                     /translation="MSALKGHPKGLYLIFATSTAERFSYYGMRAIFILFLTQALLFDKE
                     AAASIYGSYTGLVYLTPLIGGYIADKYWGIRRSVFWGAVMMAVGQFLMFMSASTLDNTN
                     LAHWMMYGGLGFLILGNGCFKPTVSSLVGQLYEPGDRRLDAAYTIFYMGVNVGSFAAPL
                     ICGYLGDTGDPHDFKWGFLAAGIMTLFTVVLFETQKNKYLFSPSGEPIGIIPDAKREKK
                     EDKADHISHPKMDKRTKVRNTLVITILTIALIAFFNYAFEGDWVSIGIFTACIVFPVLI
                     LLDGSLTKIERSRIFVIYIVAFFVIFFWAAYEQAGASLTLFASEQTNRDIFGWEMPASW
                     FQSFNPLFVVVLAYIMPGVWGFLNKRKMEPASPTKQAIGLLLLSLGYLFICFGVKDAVP
                     GVKVSMIWLTGLYFIHTMGEIALSPIGLSMVNKLSPLRFASLMMGIWYLSTATANKFAG
                     MLSGLYPEAGKVKSIFGYQIATMYDFFMVFVVMSGVASLILFLLSKKLQKMMHGVE"
     CDS             complement(5722..5946)
                     /locus_tag="ctg112_59"
                     /transl_table=11
                     /translation="MMEKTKIGLNAGKVWRILNEKGELSMFDLCRELSLTFEDVALAIG
                     WLAREDKIFLRKREGMLFASIENVEFTFG"
     CDS             6617..6733
                     /locus_tag="ctg112_60"
                     /transl_table=11
                     /translation="MRNTLKYYENKVAFEPKYGRTYEKYRFEKVFLIRYLFD"
     CDS             complement(7049..7210)
                     /locus_tag="ctg112_61"
                     /transl_table=11
                     /translation="MRATARASPPLFPGPAKIVTGVSVFHLSVMAFVNTVAARSIRSID
                     AIGSFSMV"
     CDS             7212..8519
                     /locus_tag="ctg112_62"
                     /transl_table=11
                     /translation="MAEKGYKIEVFLFNTKGELSPDCQTNKELVEMMEEVKFHEISTQF
                     VPPVLTPDHLVIDGLFGSGLNKPLSGGFAAVVKYINSSPAMVVAIDIPSGLMGEENTFN
                     VKANIIRADVTFSLQLPKLAFLFAENTEFVGEWEVLDIQLSEDGIEEMETNYEMLEIEQ
                     IRSLIKPRKQFAHKGNFGHALLIAGSKGMAGASVLAARACLRSGVGLLTVHAPMCNNDI
                     LQTSIPEAIVETDINETCFAVPTDTDDYQAVGIGPGLGRNEETEAALLEQLEHCQTPVV
                     VDADALNILANHRHALTHLPKGSILTPHPKELERLTGKCQDSYERLMKACELARAAHVH
                     IILKGAYSAIITPEGKCFFNPTGNPGMATGGSGDVLTGVILALLAQGYSTEEAAKIGTY
                     IHGLAGDVAQKKQGMIGMIASDIITCLPTAWQLVSE"
     CDS             8593..9660
                     /locus_tag="ctg112_63"
                     /transl_table=11
                     /translation="MKKLIIAAGLLMTTSAYAQTEVLTGVTRGKDYGVVYSLPKTQIEL
                     EIKANKVNYTPGEFSKYADRYLRLTNVSADPEEYWELASVKVKSVGVPNSETTYFVKLK
                     DKTVAPLMELTEDGIVKTINVPYSNSSVGKKAAPAPAVLQKKANPREFLTEEILMASST
                     AKMAELVAKEIYNIRESKNALLRGQADNMPSDGAQLKIMLDNLNAQEEAMTQMFSGTCN
                     KEERTFTVRLTPDKEFNNEVAFRFSKKLGVVANNDLAGTPFYISLKDLKSVKMPQEDGK
                     KKKDLDGIAYNVPGQAMVTLTDGKKKLYEGELPITQFGVIEYLAPVLFNKNSTIKVYFD
                     PNTGGLLKVDREEGK"
     CDS             complement(10001..10231)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RRE-containing: PqqD_RRE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF05402"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg112_64"
                     /sec_met_domain="PqqD_RRE (E-value: 6.8e-11, bitscore:
                     34.0, seeds: 9, tool: rule-based-clusters)"
                     /sec_met_domain="PF05402 (E-value: 4.9e-17, bitscore: 54.3,
                     seeds: 461, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MQRFLVPKGMSKELHVKLEEHGTAVWELIDGKRNVREIIEKLADH
                     FQNEEGYELRVSAYLSQMQKDGFIKLVIPVV"
     CDS             complement(10449..11837)
                     /gene_functions="transport (smcogs) SMCOG1106:major
                     facilitator transporter (Score: 91.6; E-value: 6.8e-28)"
                     /gene_kind="transport"
                     /locus_tag="ctg112_65"
                     /transl_table=11
                     /translation="MTEHLKQKLNDSAVLRWSVLALVAFTMLCGYFLTDVMSPLKPMLE
                     KELLWDSLDYGFFTSAYGWFNVFLLMLIFGGIILDKMGVRFTGMGACLLMVFGCGLKYY
                     AISTTFPEGAMLFGFKTQVTLAALGYAIFGVGVEIAGITVSKIIVKWFKGKEMALAMGL
                     EMATARIGTTLAMVLTVPLADFFGSTDESGTFHTNIPAPILFCLIMLCVGTIAFFLYTF
                     YDKKLDASLDAEGLEPEEPFRMNDIVYIITNKGFWLIALLCVLFYSAVFPFIKYAADLM
                     VQKYNVDPKLAGTIPGLLPIGAIILTPLFGSLYDRIGKGATLMIIGSVMLIFVHTMFAL
                     PILNIWWFATIIMIILGFAFSLVPSAMWPSVPKIIPEKQLGTAYALIFWVQNWGLMGVP
                     LLIGWVLNTYCKGPVVDGAQTYDYTLPMAIFALFGVLALIVALMLKAENKKKGYGLEEA
                     NIQK"
     CDS             complement(12087..12482)
                     /locus_tag="ctg112_66"
                     /transl_table=11
                     /translation="MYLLFVILMVIAALLMCFIVLIQNSKGGGLASGFSSSNAIMGVRK
                     TTDFLEKATWGLAIFMVVMSIATAYVVPRSAVAKDAVLEQAQKEQQTNPYNLPAGTAAP
                     QTEAPATNAPATETPAPATETPAPAAE"
     CDS             complement(12489..13262)
                     /locus_tag="ctg112_67"
                     /transl_table=11
                     /translation="MTSVNFQQWIQHPETLNRDTLYELRNLLARYPYFQSLRLLYLKNL
                     YILHDISFGGELRKAVLYIADRRQLFRLIEGDRYDVQARKKGVPLTEVLKDEPSVDRTL
                     ALIDAFLSTVPEEVTARTSFDYSMDYTSYLLEETPATEQPAEETPKLKGYELIDDFIEK
                     SESDSPLCKKPLREEMPSSPTSSDELTEEETMKEEEEDDSCFTETLAKIYVKQQRYSKA
                     LEIIKKLSLKYPKKNAYFADQIRFLEKLIINANSK"
     CDS             complement(13268..13795)
                     /locus_tag="ctg112_68"
                     /transl_table=11
                     /translation="MNWIKKIIRPLLLFGLPLVVIACTVSYKFNGSSINYDKVKTISIA
                     DFPIKSEYVYAPLATKFNEDLKDIFIRQTRLQLLKPSQNADLQIDGEITGYNQYNQAVS
                     ADGYSSETKLTITVNVRFVNNTNHAEDFEQQFSAFRTYDSSQLLTAVQDGLIAEMSKEI
                     TDQIFNATVANW"
     CDS             complement(13782..15023)
                     /gene_functions="regulatory (smcogs) SMCOG1112:sigma-54
                     dependent trancsriptional regulator (Score: 390.2; E-value:
                     2.3e-118)"
                     /gene_kind="regulatory"
                     /locus_tag="ctg112_69"
                     /transl_table=11
                     /translation="MTKAEIQQVKQRFGIIGNTEALSRAIDVAIQVAPTDLSVLITGES
                     GVGKESFPQIIHQYSRRKHGQYIAVNCGAIPEGTIDSELFGHEKGAFTGAIGERKGYFG
                     EADGGTIFLDEVGELPMSTQARLLRVLESGEFMKVGSSKVQKTDVRVVAATNVNLTQAI
                     AEGRFREDLYYRLNTVPIQIPPLRERGDDVLLLFRKFSADFAEKYRMPAIQLTEDAKKE
                     LLAYPWPGNVRQLKNITEQISIIETNREISAAILQNYLPAQNTQRLPALMGTRESKGFE
                     SEREILYSVLFDMRQEVAELKKMVHNLMAERAGQVGQVGQMGTVVTTPVVTAHQPSVPA
                     IIHTMQPTVCKDDDDIQDTEEYVEESPLSLDEVEKEMIRKALERHHGKRKSAAKDLNIS
                     ERTLYRKIKEYELD"
     CDS             complement(15033..15221)
                     /locus_tag="ctg112_70"
                     /transl_table=11
                     /translation="MYDIAGKGVACEDSFRQAIYVAIDVFRNRQREKVARANPLRKQYY
                     EKRDDSDKLKLDTVDED"
ORIGIN
        1 ttattcgaag aatacgattt cgcctccatc cgattctgta tagtttctta ataaggtctg
       61 tatcatttca gcagcttctc gcaaaccttc ttttccgtta taaccgttga ctatggctag
      121 gatatgagta gtttcgaggt ccatcttcgt acgttcatgg tcgcttgtcg gggttccgat
      181 tccgccgaaa gaatcacgat atacaggtaa tccttcgata ttcaatacac cgcgtccgat
      241 accttcaaac ggttctcctg ctttgccgat accgagttca agatgcgtac cttgtatttt
      301 gtccgcgtca aaaccaccga tcgaatgtcc tgtgcgaaga gacactaaat taataaggtc
      361 taccaacgta tcaatctgat ataaaggaat tccacgcatc aggcggcggc gtagagcttc
      421 ggctgacggg cggtaacgtc cggggtcttt gccacaacgt ttataagcct cacgggtagc
      481 aaagataacg ggttgatgtt tgatgtcttc catctgtgtt gtggaagtca gttgcccggt
      541 aaaagcgtta atttcctgcc aaagcccttc gctgtaagct gtatttttca ctgcagcata
      601 cacggcggct ccggcaaaaa ccgggcatgc gtcttttatt tctttagata cttttatttc
      661 aaacataact tatcataaac caatcatcag cgtcctgcaa taacggacac caattattac
      721 tttctaatca ttattcccga caatgtacga ccggaatcta ttcccagtct acgtgcagag
      781 aagaattcat catgatgaat ataggtacag attccggcca cttctatctg ttctgcaggc
      841 actccgagat tcagtaattc aatccggttg gcttcccaca aatcaatatg atatttgcct
      901 gtttctttct tcttcataga aataagagac atatcgaagc cgctttcttc aaaagcatca
      961 tacacctcat cacctacttc aaatgattcg agcgaaatgc tcggcccgat gcaagctatc
     1021 acatcttcgc cttgcgtccc gaacatctta ttcaagtggt ccatcacatg actgacaata
     1081 tgcttcaccg ttcccttcca tccggcatga acggcagcca caacgtgttg ttttttgtcg
     1141 tacagcaata caggaacaca atccgctgtc gtgacacaaa cgcaatatcc cggcacatta
     1201 gttatcaagg catccattcc tcgcagaagt agccgtctca tttccaatga ttctttaaaa
     1261 aatgattcat tgataatcag actggcacag ccatgattct gttcaggaat aaataattcc
     1321 tttatctgat gattcatgca ctgaaacaac cagctctgat tgcgattgac attcatacat
     1381 gagtcgttgg tataaggcga acagttgaaa gagccgtaag ctccggtgct tataccttcg
     1441 tgacgcgtag ttacaaaatg agctacttcg ggatatgcct ccagtgactt atatcccttc
     1501 aactcgttat gttttgtaag tgaaatcatt tttcttccca atcttcttct tcgtattcat
     1561 aatcgatatc atcgtcatcg tcgacatctt cctcatattc ataaacgatg tcttcatctt
     1621 cgcccatgtc tttgagttcc tgttgcagac gggtcacgtc tttcggacgg tgaacgatgt
     1681 cctctatctt attgctttcc ttgttcagtt cttcccaaag gatgtctttc aacaccgaga
     1741 tgcccaaacc ggaaacagaa gatatgaata catgtggaat gccttccggc aatgtaggtt
     1801 caatctcgtc catcaactcc tgatcgagca tatcactttt ggtgacagcc aacacacgtt
     1861 gcttgtccaa catttcagga ttgaaggtac gcagttcgtt cagcaaaact tcgtattctt
     1921 tacgaatgtc gtcgctgtct gccggaacca taaacagcag taatgaatta cgctcgatat
     1981 gacgcaagaa acgcagtccc aaaccttttc cctgactggc accttcgata atacctggta
     2041 tgtccgccat cacaaaggat tttccaccgt gataggaaac gatgcccaag ttgggttcga
     2101 gcgtagtaaa cgggtaatcg gcaattttcg gtttggcagc cgaaatggaa gaaagcaaag
     2161 ttgactttcc cgcattcggg aaacctacca gaccgacatc ggcaagcagt ttcagctcca
     2221 tgataacggt catttcctgc atcggctctc ccggctgcgc aaaacgcgga gcctgacggg
     2281 tggccgtctt gaaatgccag ttaccctgac cgccgcggcc gcctttgagc aagaccactt
     2341 cctgtccgtc ttctgttacg tcacaaagat actcccctgt ctcggcatta taaactaccg
     2401 ttccgcaggg tacttctatt attttatccg caccgtcttt tccgaagcta cgtcctttgc
     2461 tccccgattc accatgcccg gccattgcgt gacggtcata cttcaagtgc agcaatgtcc
     2521 agtaattacg gttaccgcgc aagatgatat gacctcctct tccaccatcg cccccatcag
     2581 gacctccgtt aggacaatat ttctcgcgcc tcatgtgcgt agagcctctt ccgcccttgc
     2641 ccgagcgaca gtatatcttt acgtaatcaa caaaattcga ttcagccata tttttttaaa
     2701 gagttaaagt agtcagtagt tagagcagtt aattagaaca ctccggctac tgacttattt
     2761 atttataata ttgtattatt acaatttatc tactgcttcg cagatttcag cgaagatacc
     2821 ttccatagta cccaagccgt tgatgtgttg gtatttcttt tcgttcttgt accagtcgat
     2881 cagtggagca gtctgtgaat gatatacatg cagacgtttc ttgattgttt cttcgttatc
     2941 atcagcacga ccggaatcct tgccacgttt aatgagacgt accatcagtt cttcttccgg
     3001 aacatccaag tcaaccatta cagaaacgtc ctgtcctctt tctgccaaca ttttctttaa
     3061 tgcttctgct tgtgcaattg ttcttgggaa accgtcgaaa attacccctt tgctatcttt
     3121 gaagctgtcg aatacgcttg ccagaatatc aatcattaat tcatcaggaa tcaattgacc
     3181 ttggtcgata taacctttag ctgttttacc cagttctgtg ccattcttga tttcagcacg
     3241 caatacatct cctgtcgaga tgtgattgat tccatacttt tctacgatac gttcgctctg
     3301 tgttcctttt cctgaacccg gagcaccgaa aattacgatg ttcaacattt tgttatttac
     3361 aatttaacga tttactattt accatttaaa ctggtaccta tttaatatta atctactact
     3421 gtataaatat cgggataatt acgtccgaaa ccatcataat ccagtccgta acctacgata
     3481 aagtcgttcg ggatttccat cgctacatat tcaatgttga ggtttacctt gagcttttca
     3541 ggtttcacca acagagaagc gatatgaata gcttcgggat tgcgtgtacc taatgtttcg
     3601 agcagtcgct gcatcgtcag tcctgtgtct acgatatctt ctacgatcac aatggtacgt
     3661 ccggcaatgt cttcattcag gccgattacc tctttaatca ctccggtgga agtgatgccc
     3721 tgataagacg ccaacttcac aaatgagatt tcacaaggga tggtgatgtg cttcagtaaa
     3781 tcagcagtaa acatgaacga accgttcaac acactaagga aaagcggatt cttacctgcc
     3841 aaatcgcggt tgatttcgtt cgctacgcga atcacttctt tctgaatttc ttgttcctta
     3901 atggaaacgg taaacaattt gtcttttatc tgaatggtat ccataaccgg taatttaaaa
     3961 ataaccttgc aaaaatacga ttttttattc taccccgtgc atcatcttct gtaatttctt
     4021 cgagagaagg aacagaatca acgaagcaac accggacatt acgacgaata ccataaagaa
     4081 atcatacatg gtagcaatct gataaccaaa gattgacttc acttttccgg cttccggata
     4141 gagtccgctc aacattcccg caaatttatt ggctgtggca gtagacagat accagattcc
     4201 catcatcagg gaagcgaaac gcagcggact caatttattt accattgaaa gtccgatagg
     4261 cgacaaagct atttcaccca tggtatgaat aaagtaaagt cctgtcagcc aaatcatgct
     4321 cactttcact ccgggaactg catctttcac tccgaaacag atgaaaagat aacctaaaga
     4381 aaggagtaac agaccaatcg cttgtttggt aggagaagca ggttccatct ttcgcttgtt
     4441 caggaacccc catacacccg gcatgatata tgccaggaca actacaaaca gtggattgaa
     4501 ggattgaaac catgaagccg gcatttccca accgaatatg tcacgattcg tctgttcgga
     4561 tgcgaagaga gttaaagaag ctcccgcctg ttcgtaggct gcccagaaga agatgacaaa
     4621 gaaggctact atatagataa cgaaaatacg gctgcgttct atttttgtca atgaaccgtc
     4681 taacaggatc agaacaggga aaacaatgca ggcggtaaaa atgccgatac tcacccaatc
     4741 gccttcaaat gcatagttaa agaaggctat taaagcaatg gtaagaattg tgattacaag
     4801 ggtattacgt actttggtac gtttgtccat cttcgggtgt gagatatggt cggccttgtc
     4861 ttctttcttt tcacgtttag catcggggat aataccaatc ggttctccgg aaggagaaaa
     4921 aagatattta ttcttttgag tctcgaaaag aacaacggtg aacagtgtca tgattccggc
     4981 tgcaagaaat ccccatttaa agtcatgcgg atcaccggta tcacccagat aaccacaaat
     5041 caaaggagca gcaaaagagc ctacattcac tcccatataa aaaatggtgt atgcagcatc
     5101 caaccgcctg tctccgggtt cgtagagctg acctaccaga gaagagacag tgggtttgaa
     5161 gcaaccattg cctagaatca ggaagccgag tccaccatac atcatccagt gggcaaggtt
     5221 cgtattatct aaagtggagg cactcataaa catcaggaat tgtccgactg ccatcattac
     5281 cgctccccaa aacacggaac gacggattcc ccaatattta tcggcaatgt atccgccaat
     5341 caacggggtt aaataaacta gtccggtata gctgccgtag atggatgctg ccgcttcttt
     5401 gtcaaacaat aatgcctgcg tcaggaaaag aataaagatc gcacgcatac cgtagtaact
     5461 gaaacgttct gccgtgcttg tcgcgaaaat cagataaagg cctttcggat gccctttcaa
     5521 tgcactcatg aatttatgtg tttagtagtt tatggggtgc aaaggtacag aaaaagtaga
     5581 ttagatgctt ctcttatcaa acagaataat agggggaata gtaaaaacga gcataaaaat
     5641 cctactgatc cacttcatta cttttttagc agtgtaaata ataaagtgga gatccatctt
     5701 aaatgtaggt tagctaccac cttagccaaa agtaaattcg acattttcga tactggcaaa
     5761 aagcattcct tctcttttcc tcaaaaagat tttgtcttct cgggccagcc aaccaatagc
     5821 gagagctacg tcttcaaacg tcaaacttaa ttcacggcac aaatcgaaca ttgaaagttc
     5881 acctttttca tttaagatgc gccatacttt cccggcattc aagccaattt ttgtcttttc
     5941 catcatgcaa actttagaag attaaacaat ccgttattta gattttaatt cattttcatt
     6001 gtgagcactg gaaaatgatg tgatgcacat tatctatctc caaagataac atttttatcg
     6061 gaaacggcaa ataatcaaag gcttaataag gggaaccgca ttaaaaattt gtttaagaag
     6121 gtatggcgat aaactaaaca caattttcat ccgcgcctct acagaaaaag atttttcatt
     6181 tctcatattc tcataaataa gaaacaagtg gcagtaaact aataagatag actatgagaa
     6241 atgatttaaa aacaggcatt tctcatagtt tcttcgcaaa ataacccgga ttttgcttca
     6301 tttctcatag tgtagtgtgc cggaagctga cattgaataa ataaaactat gtattccttt
     6361 tgcttgcttc catacacagt gtcttagttc cacatattgt gggaaaagat tccctaaggc
     6421 ttgggaaagt attcccgtat tttgtaggaa agtattcccg tatattgaag gaaaactttc
     6481 ccacaatata tgggacaatc gagaccaatg agcatcttca agcaaaaagc cactatttta
     6541 tctaaatagt agcttcattt cctgataaaa ataaggcagg ctgaaagaaa aaaggaagaa
     6601 caaatggctt ttgactatga gaaataccct gaaatactat gagaataagg tggcttttga
     6661 gccaaaatat gggagaactt atgagaaata ccgtttcgaa aaagtgtttc tcataagata
     6721 tctatttgat tagctttcgt ttatcgaaaa acaatgagaa tatgagaaat gaaatgaaga
     6781 aatctttttc aggagaaata aaagtaagtt cataatggtg ctgcattgaa ttattttttg
     6841 gcggagttat tctaacactt aatagttcaa aagcagatat ttctctgacc caaagataga
     6901 actaatgatg aattaaaagt tgcaattatg gttttcttcc cacaacaaac gggaaaagtc
     6961 agaagaatca tgtacatttg taatccgaaa actaaaagaa catcgcaatg aaaatatttc
     7021 caagcagcag tatcaagaaa ttggacgctt ataccattga gaacgaacct attgcatcaa
     7081 tcgatctgat ggaacgtgca gcaaccgtat taacaaaagc catcacagac agatggaata
     7141 cggaaacgcc ggtcactatc tttgccggac cggggaataa tggcggagac gctctcgccg
     7201 tagcccgcat gatggctgaa aaaggatata aaatcgaggt atttctcttc aacacgaaag
     7261 gagaactttc acccgactgc caaaccaata aagaactggt agaaatgatg gaagaagtaa
     7321 aattccacga aatcagtacc caattcgtac ctcccgtcct gacgcccgac catctggtaa
     7381 tcgacggatt attcggttca ggcctgaaca aaccgttaag cggcggattc gctgccgtag
     7441 tgaaatacat caattcctcc cctgctatgg tagtagccat cgacattcct tccggactga
     7501 tgggagaaga aaacacattc aacgtaaaag ctaatattat ccgtgccgac gtaactttca
     7561 gtctgcaact gccgaagctc gcctttcttt tcgcagagaa cacggaattt gtcggagaat
     7621 gggaagtgct ggacatccaa ttaagcgaag acggtattga agagatggaa acgaactacg
     7681 aaatgttgga aatagagcaa atccgttcac tcatcaagcc acgcaaacag tttgcccaca
     7741 aggggaactt cggccatgca ctattgattg ccggttcaaa aggaatggca ggagcctctg
     7801 ttctcgctgc ccgcgcctgc ctccgttcgg gagtagggtt gctgactgtc catgcgccaa
     7861 tgtgcaacaa cgacatcttg caaacctcca tacccgaagc aatcgtagaa accgacatca
     7921 acgaaacctg ttttgccgta cctaccgaca cggacgacta tcaagcagtc ggcatcggcc
     7981 cagggctggg acgaaacgag gaaacggaag ctgctttatt ggagcaactg gaacattgcc
     8041 agactcctgt tgtggtggat gccgacgcac ttaatatcct cgccaaccac cgtcatgcac
     8101 ttacccacct gccgaagggt tccatcctca ccccgcatcc gaaagaactg gaacgtctga
     8161 ccggcaaatg ccaggactct tacgaacgtc tgatgaaggc ttgcgaattg gctcgtgccg
     8221 cccatgttca cattatttta aaaggagcct actccgccat tatcacccca gaaggtaaat
     8281 gtttcttcaa cccaaccgga aatccgggaa tggcaaccgg aggtagcggt gacgtactga
     8341 ccggagtaat cctggcactg cttgcccaag gttactcaac cgaagaagcc gctaaaatcg
     8401 gcacttacat tcacggattg gcgggcgatg tcgctcaaaa gaagcaagga atgatcggaa
     8461 tgatcgcaag cgatattatc acctgtctgc cgacagcatg gcaacttgta agcgaataaa
     8521 agttaagaac ttaccctttt ttcaataact tcattaactt tgttttcaaa accagttaaa
     8581 aaagaaccga atatgaaaaa gttgattata gcagcaggac tactaatgac aacgtccgcc
     8641 tatgcacaaa ccgaagtact gacaggggtt acccgaggaa aagactatgg agtggtttac
     8701 agtcttccca aaacccaaat agaacttgaa ataaaagcca acaaagtcaa ctatactccg
     8761 ggagaattca gcaaatatgc tgatcgttac ctgcgactga ccaacgtctc cgccgatcct
     8821 gaagagtact gggaactggc tagcgtaaaa gtgaaatccg taggtgtgcc caacagcgaa
     8881 actacgtatt tcgtaaaatt gaaggataag acagtagcac cgcttatgga actgacagag
     8941 gatggcattg tgaaaacgat caatgttcct tacagcaata gcagtgtagg caaaaaagct
     9001 gctcccgccc ccgcagtcct ccaaaagaaa gcgaatcctc gcgaattcct gaccgaagag
     9061 attctgatgg ctagctctac cgccaagatg gccgagctgg tggctaaaga aatctataac
     9121 atccgcgaaa gcaaaaatgc cttattgcgc ggacaggctg acaatatgcc ttcagacgga
     9181 gcacagctta agattatgct cgacaatctg aatgcacagg aagaagccat gacgcaaatg
     9241 ttctccggca cctgcaacaa agaagagaga acattcactg tccgccttac ccctgacaag
     9301 gaattcaaca atgaagttgc tttccgcttc tcgaagaagt taggtgtagt tgccaacaat
     9361 gatttggcag gaactccgtt ttatatcagt ctgaaagacc tgaaatcggt caagatgcca
     9421 caggaagatg gtaagaagaa gaaagatttg gatggaatcg cctacaacgt acccggacaa
     9481 gctatggtta cactgaccga cggtaaaaag aaactttacg aaggtgagct tcctattacc
     9541 caatttggtg tgatagaata tctggctccg gttttgttca acaagaattc taccatcaaa
     9601 gtttattttg atccgaatac gggaggattg ctcaaagtgg acagagaaga agggaaatag
     9661 aaaaacgaag gaagtgaact tctaaaaaac aaagaatatg gttggtgaag gacatgcatt
     9721 cgacatgata cgccgaataa aagagggacg ggaagcttcc cgcctacgtc gtgaacgtgc
     9781 taacgataag ttgaagcatc taaaccgtgc aaacgaacct tatccactac ccaacaccac
     9841 ccccgaagaa atggaacgta tcatccacga ctcggagaaa aagaaagaga aagacagcaa
     9901 ttattttgtt tggggaacgc ttattatcat gggagtcctg atagcaattg ccgtcatact
     9961 ttgggctgta tttatcaaat aaataataat aagttcctat ttatacgact ggtatcacca
    10021 gttttataaa tccatctttc tgcatttgag aaagataagc cgatacacgc aactcgtagc
    10081 cctcttcatt ttgaaagtgg tctgcgagtt tttctataat ctcacgaaca ttgcgttttc
    10141 catctatcag ttcccataca gctgtaccgt gttcttccaa tttcacatga agttctttcg
    10201 acattccttt tggcacaagg aagcgttgca tccacggata tttaaaacgg ggaaaggaga
    10261 gcacaattgt ctccccttcc ctttctgctg taatatgttc actgcgacag ggaatgacct
    10321 ctaacaggtt gattttctct ttggcagcca tacttcttat tttttatttc agagtattca
    10381 tactgatact cttctgttta caccttgata caaaattcct ttgttacttt aggtattgaa
    10441 tttcctagtt acttttggat attcgcctct tccaaaccgt atcccttctt cttgttctct
    10501 gccttcaaca tcaaagccac aatcagagca agcacaccaa agagagcaaa aatagccatc
    10561 ggcaacgtgt aatcataagt ctgtgcaccg tctactaccg gacctttgca ataagtattc
    10621 aacacccatc cgatcaacaa aggaacaccc atcaatcccc agttctgtac ccagaaaatc
    10681 aatgcatatg cggtacccaa ctgtttttcc ggaataatct tcggaacaga cggccacata
    10741 gctgaaggca ccaacgagaa ggcaaatccc aatataatca tgatgatagt agcaaaccac
    10801 catatattca gtataggcag agcaaacatc gtatgcacaa aaataagcat cactgatccg
    10861 attatcatca atgtggctcc cttaccaata cggtcataaa gcgagccgaa caacggagtc
    10921 aggataatcg caccaatcgg caacaatccg ggaatcgttc ccgccaactt cggatctacg
    10981 ttatacttct gcaccatcaa gtcggcagca tacttgataa aggggaatac agccgagtag
    11041 aacaatacac atagtaatgc aatcagccag aatcctttat tggtaatgat atacacaata
    11101 tcattcatac ggaacggctc ttccggctcc aatccttctg catccaaaga agcatccaac
    11161 ttcttatcat agaaagtata aaggaagaaa gcaatcgtac ccacgcacaa cataatcaga
    11221 caaaacaaaa tcggagcagg aatattggta tgaaatgtgc cactctcatc cgtagatccg
    11281 aaaaagtcgg ccaaaggaac cgtgagcacc attgccagag ttgttccgat acgtgccgta
    11341 gccatttcaa gtcccatagc caatgccatt tccttaccct tgaaccattt cacgataatt
    11401 ttggaaactg tgataccggc aatttccaca cctacaccga agatagcata ccccaatgca
    11461 gccagggtta cctgtgtttt gaatccgaag agcatggcac cttccggaaa agtagtagaa
    11521 atcgcatagt atttcaatcc acaaccaaac accatcaata agcaagctcc cattccggta
    11581 aaacgaactc ccatcttatc caaaatgata ccaccgaaaa tcagcatcaa taggaataca
    11641 ttaaaccacc cgtaagcact tgtgaagaaa ccataatcaa gactgtccca tagtagttct
    11701 ttctcaagca tgggttttag aggagacatt acgtcggtga ggaaatagcc gcatagcata
    11761 gtaaatgcga ccaatgctag aacactccat cggagtacgg cggagtcatt caatttctgt
    11821 ttcaaatgtt ctgtcattgt tatatttaaa aatagtagtt aataatcttc atacgaccaa
    11881 caaaggtagt taaatctcgt ttgtttctat caaaaagaga ttgtttttac aagaaaaagt
    11941 taagtgcgga ttacactgac cacgcggaag attgaaaatc cgtgtaatct gcgtaatccg
    12001 cacttaaata tcaaagaaat gcagcatccg tctgcacctt cccattaatg gttttacccc
    12061 aaagtcttac ctgacaacgg agtgaattac tctgctgcag gagcaggagt ttcagtagcc
    12121 ggtgccggag tttctgtagc aggtgcattg gtagcaggag cttcagtttg cggcgcagcc
    12181 gtacctgcgg gtaagttata cgggttagtc tgttgttctt tctgtgcctg ttccaacact
    12241 gcgtctttag caacagcaga gcgaggaact acataagcag tagcaatgct cattaccacc
    12301 atgaagatag ctaagcccca tgttgctttt tccagaaaat ctgtagtctt gcgcacgccc
    12361 atgatggcgt tagatgaaga gaaaccagaa gcaagtccgc ctccttttga gttctgaatc
    12421 agcacgatga aacacatcaa caaggctgca ataaccatta agataacgaa taataagtac
    12481 atttttagtt attttgaatt agcgttaata atcaatttct ccaaaaatct gatttggtct
    12541 gcaaagtaag catttttttt tggatatttc aagcttaatt ttttaattat ttcaagagct
    12601 tttgaatatc gttgctgttt aacatagatt tttgccaaag tttccgtaaa acagctgtca
    12661 tcttcctctt cttccttcat cgtttcttct tcggtaagtt cgtccgaaga ggttggcgaa
    12721 gatggcattt cttctcttaa aggtttcttg cagaggggag agtcgctctc gctcttttct
    12781 ataaagtcgt caatcagttc gtagcctttg agtttgggcg tttcttcggc cggctgttcc
    12841 gtggccggag tctcctccaa aagataagag gtgtaatcca tcgaatagtc gaagctggtg
    12901 cgggcagtca cctcttcggg tactgtggac aagaaagcgt cgatcaatgc taatgtgcgg
    12961 tctacggacg gttcgtcttt cagcacctcc gtgagaggta ctcccttttt ccgtgcctgc
    13021 acatcatagc ggtcaccttc aatcaaccgg aacaactgcc gtctgtctgc aatgtaaaga
    13081 actgctttcc gcagttctcc accaaaacta atatcatgga gaatatacag attcttcaga
    13141 tacagcagac gaagtgactg aaaatacgga tacctcgcaa gaagattgcg cagttcgtac
    13201 aaagtatccc tattcagcgt ctcgggatgc tgaatccatt gttgaaagtt aacagaagtc
    13261 atttatatta ccagtttgct acagttgcat taaaaatttg gtcggtgatc tctttagaca
    13321 tttcagcaat caatccgtcc tgtacggcag tcagcaactg gctagagtcg taggtacgga
    13381 acgcagaaaa ctgttgttca aagtcttcgg catgattggt gttgttgaca aaacgtacat
    13441 taacggtgat agtcaacttc gtctccgaag aataaccgtc ggcagataca gcctgattgt
    13501 actgattgta acctgtgatt tctccgtcaa tctgcaagtc ggcattttga ctcggcttga
    13561 gcagttgcag acgggtctgc cggatgaaga tatctttcag gtcctcatta aacttggttg
    13621 ccaacggagc atacacatac tccgacttga tcgggaagtc ggctatcgaa atggtcttta
    13681 ccttatcata attgatagac gatccgttaa acttatagga aacagtgcac gcaatgacta
    13741 ccaacggcaa gccgaacagt aacaaagggc gtattatttt cttaatccaa ttcatattct
    13801 tttatttttc tatagagtgt acgctcggaa atattcaagt ccttggccgc actcttccgc
    13861 tttccatgat gcctctcaag tgctttgcgt atcatttctt tctccacttc gtccagtgac
    13921 aaaggagatt cttctacata ttcttccgtg tcttgtatgt catcatcatc cttgcaaacc
    13981 gtgggctgca tggtgtgaat gatagcaggt accgaaggtt gatgcgccgt cactaccgga
    14041 gtagtaacca ccgttcccat ttgtcctacc tgccccacct gtccggcacg ttccgccatc
    14101 aggttgtgca ccatcttctt cagctccgcc acttcctggc gcatatcgaa cagaacagaa
    14161 taaagaatct cccgttcgct ctcaaagcct ttactctcac gcgttcccat cagcgcggga
    14221 agacgttgcg tattttgtgc gggaagataa ttctgcaaga tagcagcaga gatctcccta
    14281 ttggtttcaa tgatagatat ttgctcggtg atattcttca actgacgcac gtttcctggc
    14341 cacgggtaag ccaacaactc tttcttcgca tcctccgtca actgaatagc aggcatccgg
    14401 tatttctctg caaagtctgc ggaaaactta cggaacaaca ggagcacatc gtcaccacgt
    14461 tcacgcaaag gcggtatctg gataggcacc gtattcaacc ggtaatataa atcttcacgg
    14521 aaacgtcctt ctgcaatcgc ttgtgtcaga ttgacgttgg tagccgccac cacacgcaca
    14581 tccgtttttt gtactttgga cgaacctact ttcataaact cgccactctc cagtacacgg
    14641 agcaaacgtg cctgggtaga catcggcaac tcccctactt catcaagaaa aatagtaccg
    14701 ccgtcagctt cgccaaagta ccctttccgt tcgccaatcg caccggtaaa cgcacctttc
    14761 tcatgtccga acagttcgga atcaatcgta ccctccggaa tagcaccaca gttgacagca
    14821 atatactgcc cgtgcttcct ccggctatat tgatgaataa tctgcggaaa actttctttc
    14881 ccgactccac tttctccggt aatcagcaca gacaaatcgg taggagctac ctgaatggca
    14941 acatctatgg cgcgcgacaa tgcttcagta tttccaataa taccgaaacg ctgtttcact
    15001 tgttgtatct ctgctttcgt catcactcgt ttttaatctt cgtctactgt atccagcttc
    15061 agtttatcac tatcgtcacg tttctcgtaa tactgtttac gcaacggatt ggcacgagcc
    15121 actttttccc gctgacgatt acggaacacg tcgatggcaa catagattgc ctgacggaaa
    15181 gaatcttcac aagccactcc cttacctgca atatcgtatg c
//
