LOCUS       gnlProkkaMMFFGJPD_339  15217 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|MMFFGJPD_339.
ACCESSION   gnlProkkaMMFFGJPD_339
VERSION     gnlProkkaMMFFGJPD_339
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2024-11-30 23:14:36
            Original ID  :: gnl|Prokka|MMFFGJPD_339
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 15217
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..15217
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="True"
                     /core_location="[4986:5217]"
                     /cutoff="10000"
                     /detection_rule="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /neighbourhood="10000"
                     /product="RRE-containing"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      4987..5217
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /neighbourhood="10000"
                     /product="RRE-containing"
                     /protocluster_number="1"
     cand_cluster    1..15217
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /kind="single"
                     /product="RRE-containing"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..15217
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="RRE-containing"
                     /region_number="1"
                     /rules="minimum(1, [Bottromycin_Methyltransferase_RRE,
                     Cyanobactin_D_RRE, Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /tool="antismash"
     CDS             3..185
                     /locus_tag="ctg339_1"
                     /transl_table=11
                     /translation="MIAGKGLACEDSFRQAIYVAIDVFRNRQREKVARANPLRKQYYEK
                     RDDSDKLKLDTVDED"
     CDS             195..1436
                     /gene_functions="regulatory (smcogs) SMCOG1112:sigma-54
                     dependent trancsriptional regulator (Score: 385.8; E-value:
                     4.8e-117)"
                     /gene_kind="regulatory"
                     /locus_tag="ctg339_2"
                     /transl_table=11
                     /translation="MTRAEIQQVKQRFGIIGNTEALSRAIDVAIQVAPTDLSVLITGES
                     GVGKESFPQIIHQYSRRKHGQYIAVNCGAIPEGTIDSELFGHEKGAFTGAIGERKGYFG
                     EADGGTIFLDEVGELPMPTQARLLRVLESGEFIKVGSSKVQKTDVRIVAATNVNLTQAI
                     AEGRFREDLYYRLNTVPIQIPPLRERGDDVLLLFRKFSADFAEKYRMPAIQLTEDAKKE
                     LLAYPWPGNVRQLKNITEQISIIETNREISAAILQNYLPAQNTQRLPALMGTRESKGFE
                     SEREILYSVLFDMRQEVAELKKMVHNLMAERAGQVGQVGQVGTVVTTPVVTTHQPSVPA
                     IIHTMQPAVCKDDDDIQDTEEYVEEPPLSLDEVEKEMIRKALERHHGKRKSAAKDLNIS
                     ERTLYRKIKEYELD"
     CDS             complement(1456..1806)
                     /locus_tag="ctg339_3"
                     /transl_table=11
                     /translation="MIGVVDKTHIDGDSQLRLRRITVGRYCLVVLIVPCDFSVNLQVGI
                     LTRLEQLQTGLPDEDIFQVLIEFGCQRSIYILRLDREVGYRNGLYLIIIDRRSVKLIGN
                     SARNDYQRQAEQ"
     CDS             1956..2729
                     /locus_tag="ctg339_4"
                     /transl_table=11
                     /translation="MTSVNFQQWIQHPETLNRDTLYELRNLLARYPYFQSLRLLYLKNL
                     YILHDISFGGELRKAVLYIADRRQLFRLIEGDRYDVQARKKGIPLTEVLKDEPSVDRTL
                     ALIDAFLSTVPEEVTARTSFDYSMDYTSYLLEETPATEQPAEETPKLKGFELIDDFIEK
                     SESDSPLCMKPLREEMPSSPTSSDELTEEETMKEEEEDDSCFTETLAKIYVKQQRYSKA
                     LEIIKKLSLKYPKKNAYFADQIRFLEKLIINANSK"
     CDS             2736..3131
                     /locus_tag="ctg339_5"
                     /transl_table=11
                     /translation="MYLLFVILMVIAALLMCFIVLIQNSKGGGLASGFSSSNAIMGVRK
                     TTDFLEKATWGLAIFMVVMSIATAYVVPRSAVAKDAVLEQAQKEQQTNPYNLPAGTAAP
                     QTEAPATNAPATETPAPAAETPAPAAE"
     CDS             3459..4769
                     /gene_functions="transport (smcogs) SMCOG1106:major
                     facilitator transporter (Score: 85.5; E-value: 4.7e-26)"
                     /gene_kind="transport"
                     /locus_tag="ctg339_6"
                     /transl_table=11
                     /translation="MLCGYFLTDVMSPLKPMLEKELLWDSLDYGFFTSAYGWFNVFLLM
                     LIFGGIILDKMGVRFTGMGACLLMVFGCGLKYYAISTTFPEGAMLFGFKTQVTLAALGY
                     AIFGVGVEIAGITVSKIIVKWFKGKEMALAMGLEMATARIGTTLAMVLTVPLADFFGST
                     DESGTFHTNIPAPILFCLIMLCVGTIAFFLYTFYDKKLDASLDAEGLEPEEPFRMKDIV
                     YIITNKGFWLIALLCVLFYSAVFPFIKYAADLMVQKYNVDPKLAGTIPGLLPIGAIILT
                     PLFGSLYDRIGKGATLMIIGSVMLIFVHTMFALPILNIWWFATIIMIILGFAFSLVPSA
                     MWPSVPKIIPEKQLGTAYALIFWVQNWGLMGVPLLIGWVLNTYCKGPVVDGAQTYDYTL
                     PMAIFALFGVLALIVALMLKAENKKKGYGLEEANIQK"
     CDS             4987..5217
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RRE-containing: PqqD_RRE"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RRE-containing: Stand_Alone_Lasso_RRE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF05402"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg339_7"
                     /sec_met_domain="PqqD_RRE (E-value: 8.2e-12, bitscore:
                     35.4, seeds: 9, tool: rule-based-clusters)"
                     /sec_met_domain="PF05402 (E-value: 3.6e-18, bitscore: 56.3,
                     seeds: 461, tool: rule-based-clusters)"
                     /sec_met_domain="Stand_Alone_Lasso_RRE (E-value: 1.5e-08,
                     bitscore: 25.3, seeds: 25, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MQRFLVPKGMSKELHVKLEEHGTAVWELIDGKRNVREIIEKLADH
                     FQNEEGYESRVSAYLSQMQKDGLIKLVIPVV"
     CDS             complement(5236..5520)
                     /locus_tag="ctg339_8"
                     /transl_table=11
                     /translation="MVGEGHAFDMIRRIKEGREASRLRRERANDKLKHINRANEPYPLP
                     NTTPEEMERIIHDSEKKKEKDSNYFVWGTLIIMGVLIAIAVILWAVFIK"
     CDS             complement(5557..6624)
                     /locus_tag="ctg339_9"
                     /transl_table=11
                     /translation="MKKLIIAAGLLMTTSAYAQTEVLTGVTRGKDYGVVYSLPKTQIEL
                     EIKANKVNYTPGEFSKYADRYLRLTNVSADPEEYWELASVKVKSVGVPNSETTYFVKLK
                     DKTVAPLMELTEDGIVKTINVPYSNSSAGKKVAPAPAVLQKKANPREFLTEEILMASST
                     AKMAELVAKEIYNIRESKNALLRGQADNMPSDGAQLKIMLDNLNAQEEAMTQMFSGTCN
                     KEERTFTVRLTPDKEFNNEVAFRFSKKLGVVANNDLAGTPFYISLKDLKSVKIPQEDDK
                     KKKDLDGIAYNVPGQAMVTLTDGKKKLYEGELPITQFGVIEYLAPVLFNKNSTIKVYFD
                     PNTGGLLKVDREEGK"
     CDS             complement(6697..8208)
                     /locus_tag="ctg339_10"
                     /transl_table=11
                     /translation="MKIFPSSSIKKLDAYTIENEPIASIDLMERAATVLTKAITDRWNT
                     ETPVTIFAGPGNNGGDALAVARMMAEKGYKIEVFLFNTKGELSPDCQTNKELVEMMEEV
                     KFHEISTQFVPPALTPDHLVIDGLFGSGLNKPLSGGFAAVVKYINSSPTMVVAIDIPSG
                     LMGEENTFNVKANIIRADVTFSLQLPKLAFLFAENTEFVGEWEVLDIQLSEDGIEEMET
                     NYEMLEIEQIRSLIKPRKQFAHKGNFGHALLIAGSKGMAGASVLAARACLRSGVGLLTV
                     HAPMCNNDILQTSIPEAIVETDINETCFAVPTDTDDYQAVGIGPGLGRNEETEAALLEQ
                     LEHCQTPVVVDADALNILANHRHALTHLPKGSILTPHPKELERLTGKCQDSYERLMKAC
                     ELARAAHVHIILKGAYSAIITPEGKCFFNPTGNPGMATGGSGDVLTGVILALLAQGYPT
                     EEAAKIGTYIHGLAGDVAQKKQGMIGMIASDIITCLPTAWRLVSE"
     CDS             9270..9494
                     /locus_tag="ctg339_11"
                     /transl_table=11
                     /translation="MMEKTKIGLNAGKVWRILNEKGELSMFDLCRELSLTFEDVALAIG
                     WLAREDKIFLRKREGMLFASIENVEFTFG"
     CDS             9688..11232
                     /gene_functions="transport (smcogs) SMCOG1202:major
                     facilitator transporter (Score: 46.8; E-value: 2.5e-14)"
                     /gene_kind="transport"
                     /locus_tag="ctg339_12"
                     /transl_table=11
                     /translation="MSALKGHPKGLYLIFATSTAERFSYYGMRAIFILFLTQALLFDKE
                     AAASIYGSYTGLVYLTPLIGGYIADKYWGIRRSVFWGAVMMAVGQFLMFMSASTLDNTN
                     LAHWMMYGGLGFLILGNGCFKPTVSSLVGQLYEPGDRRLDAAYTIFYMGVNVGSFAAPL
                     ICGYLGDTGDPHDFKWGFLAAGIMTLFTVVLFETQKNKYLFSPSGEPIGIIPDAKREKK
                     EDKADHISHPKMDKRTKVRNTLVITILTIALIAFFNYAFEGDWVSIGIFTACIVFPVLI
                     LLDGSLTKIERSRIFVIYIVAFFVIFFWAAYEQAGASLTLFASEQTNRDIFGWEMPASW
                     FQSFNPLFVVVLAYIMPGVWGFLNKRKMEPASPTKQAIGLLLLSLGYLFICFGVKDAVP
                     GVKVSMIWLTGLYFIHTMGEIALSPIGLSMVNKLSPLRFASLMMGIWYLSTATANKFAG
                     MLSGLYPEAGKVKSIFGYQIATMYDFFMVFVVMSGVASLILFLLSKKLQKMMHGVE"
     CDS             11273..11809
                     /locus_tag="ctg339_13"
                     /transl_table=11
                     /translation="MDTIQIKDKLFTVSIKEQEIQKEVIRVANEINRDLAGKNPLFLSV
                     LNGSFMFTADLLKHITIPCEISFVKLASYQGITSTGVIKEVIGLNEDIAGRTIVIVEDI
                     VDTGLTMQRLLETLGTRNPEAIHIASLLVKPEKLKVNLNIEYVAMEIPNDFIVGYGLDY
                     DGFGRNYPDIYTVVD"
     CDS             11869..12438
                     /locus_tag="ctg339_14"
                     /transl_table=11
                     /translation="MLNIVIFGAPGSGKGTQSERIVEKYGINHISTGDVLRAEIKNGTE
                     LGKTAKGYIDQGQLIPDELMIDILASVFDSFKDSKGVIFDGFPRTIAQAEALKKMLAER
                     GQDVSVMVDLDVPEEELMVRLIKRGKDSGRADDNEETIKKRLHVYHSQTAPLIDWYKNE
                     KKYQHINGLGTMEGIFAEICEAVDKL"
     CDS             12603..13691
                     /locus_tag="ctg339_15"
                     /transl_table=11
                     /translation="MRREKYCPNGGPDGGDGGRGGHIILRGNRNYWTLLHLKYDRHAMA
                     GHGESGSKGRSFGKDGADKIIEVPCGTVVYNAETGEYLCDVTEDGQEVVLLKGGRGGQG
                     NWHFKTATRQAPRFAQPGEPMQEMTVIMELKLLADVGLVGLPNAGKSTLLSSISAAKPK
                     IADYPFTTLEPNLGIVSYHGGKSFVMADIPGIIEGASQGKGLGLRFLRHIERNSLLLFM
                     VPADSDDIRKEYEVLLNELRTFNPEMLDKQRVLAVTKSDMLDQELMDEIEPTLPEGIPH
                     VFISSVSGLGISVLKDILWEELNKESNKIEDIVHRPKDVTRLQQELKDMGEDEDIVYEY
                     EEDVDDDDDIDYEYEEEDWEEK"
     CDS             13688..14500
                     /locus_tag="ctg339_16"
                     /transl_table=11
                     /translation="MISLTKYNELKGYKSLEAYPEVAHFVTTRHEGISTGAYSSFNCSP
                     YTNDSCMNVNRNQSWLFQCMNHQIKELFIPEQNHGCASLIINESFFKESLEMRRLLLRG
                     MDALITNVPGYCVCVTTADCVPVLLYDKKQHVVAAVHAGWKGTVKHIVSNVMDHLNKMF
                     GTQGEDVIACIGPSISLESFEVGDEVYDAFEESGFDMSLISMKKKETGKYHIDLWEANR
                     IELLNLGVPAEQIEVAGICTYIHHDEFFSARRLGIDSGRTLSGIMIRK"
     CDS             14551..15216
                     /locus_tag="ctg339_17"
                     /transl_table=11
                     /translation="MFEIKVSKEIKDACPVFAGAAVYAAVKNTAYSEGLWQEIDAFTRQ
                     LTSTTQMEDIKHQPVIFATREAYKRCGKDPGRYRPSAEALRRRLMRGIPLYQIDTLVDL
                     INLVSLRTGHSIGGFDADKIQGTHLELGIGKAGEPFEGIGRGVLNIEGLPVYRDSFGGI
                     GTPTSDHERTKMDLGTTHILAIVNGYNGKEGLQEAVEMIQTLLRNYTESDGGEIAFFE"
ORIGIN
        1 acgatattgc aggcaaggga ttggcttgtg aagattcttt ccgtcaggca atctatgttg
       61 ccatcgatgt gttccgtaat cgtcagcggg aaaaagtggc tcgtgccaat ccgttgcgta
      121 aacagtatta cgagaaacgt gacgatagtg ataaactgaa gctggataca gtagacgaag
      181 attaaaaacg agtgatgacg agagcagaga tacaacaagt gaaacaacgt ttcggtatta
      241 ttggaaatac tgaagcattg tcgcgcgcca tagatgttgc cattcaggta gctcctaccg
      301 atttgtctgt gctgattacc ggagaaagtg gagtcggaaa agaaagtttt ccgcagatta
      361 ttcatcaata tagccggagg aagcacggac agtatattgc tgtcaactgt ggtgctattc
      421 cggagggcac gattgattcc gaactgttcg ggcatgagaa gggtgcgttt accggtgcga
      481 ttggcgaacg gaaagggtac tttggcgaag ccgacggtgg tactattttc ctagatgaag
      541 taggggagtt gccgatgcct acccaggcgc gtttgctccg tgtgttggag agtggcgagt
      601 ttataaaagt aggttcgtcc aaagtgcaaa agacggatgt tcgtattgtg gcagctacca
      661 atgtcaatct gacacaagcg attgcagaag gacgtttccg tgaagattta tattaccggt
      721 tgaatacggt gcctatccaa ataccgcctt tgcgtgaacg tggtgacgat gtacttttgt
      781 tgttccgtaa gttttccgca gactttgcag agaaataccg gatgcctgct atccagttga
      841 cggaggatgc gaagaaagag ttattggctt acccgtggcc cggaaacgtg cgtcagttga
      901 agaacatcac cgagcaaata tctatcattg aaaccaacag ggagatctct gctgctatct
      961 tgcagaatta tcttcccgca caaaatacgc aacgtcttcc cgcgctgatg ggaacgcgtg
     1021 agagtaaagg ctttgagagc gaacgggaga ttctttattc tgttctgttc gatatgcgcc
     1081 aggaagtggc ggagctgaag aagatggtgc acaacctgat ggcggaacgt gccggacagg
     1141 tgggacaggt aggacaagtg ggaacggtgg ttactactcc ggtagtgacg acacaccagc
     1201 cttcggtacc tgcgatcatt cataccatgc agcctgcggt ttgcaaggat gatgacgaca
     1261 tacaagacac ggaagaatat gtagaagaac ctcctttgtc actggacgaa gtggaaaaag
     1321 aaatgatacg caaagcactt gaaaggcatc acggaaagcg gaagagtgcg gccaaggact
     1381 tgaatatttc cgagcgtaca ctttatagaa aaataaaaga atatgaattg gattaagaaa
     1441 ataatacgcc ctttgctact gttcggcttg ccgttggtag tcattgcgtg cactgtttcc
     1501 tataagttta acggatcgtc tatcaattat gataaggtaa agaccatttc gatagccgac
     1561 ttcccgatca agtcggagta tgtatatgct ccgttggcaa ccaaattcaa tgaggacctg
     1621 aaagatatct tcatccggca gacccgtctg caactgctca agccgagtca aaatgccgac
     1681 ttgcagattg acggagaaat cacagggtac aatcagtaca accaggcagt atctgccgac
     1741 ggttattctt cggagacgaa gttgactatc accgtcaatg tgcgttttgt caacaacacc
     1801 aatcatgccg aagactttga acaacagttt tctgcgttcc gtacctacga ctctacccag
     1861 ttgttgactg ccgtacagga cggattgatt gctgaaatgt ctaaagagat caccgaccaa
     1921 atttttaatg caactgtagc aaactggtaa tataaatgac ttctgttaac tttcaacaat
     1981 ggattcagca tcccgagacg ctgaataggg atactttgta cgaactgcgc aatcttcttg
     2041 cgaggtatcc gtattttcag tcacttcgtc tgctgtatct gaagaatctg tatattctcc
     2101 atgatattag tttcggtgga gaactgcgga aagcagttct ttacattgca gacagacggc
     2161 agttgttccg gttgattgaa ggtgaccgct atgatgtgca ggcacggaaa aagggaatac
     2221 ctcttacgga ggtgctgaaa gacgaaccgt ccgtagaccg cacattagca ttgatcgacg
     2281 ctttcttgtc cacagtaccc gaagaggtga ctgcccggac cagtttcgac tattcgatgg
     2341 attacacttc ttatcttttg gaggagactc cagccacgga acagccggcc gaagaaacgc
     2401 ccaaactcaa aggcttcgaa ctgattgacg actttataga aaagagcgag agcgactctc
     2461 ccctctgcat gaaaccttta agagaagaaa tgccatcttc gccaacctct tcggacgaac
     2521 ttaccgaaga agaaacgatg aaggaagaag aggaagatga cagctgtttt acggaaactt
     2581 tggcaaaaat ctatgttaaa cagcaacgat attcaaaagc tcttgaaata attaaaaaat
     2641 taagcttgaa atatccaaaa aaaaatgctt actttgcaga ccaaatcaga tttttggaga
     2701 aattgattat taacgctaat tcaaaataac taaaaatgta cttattattc gttatcttaa
     2761 tggttattgc agccttgttg atgtgtttca tcgtgctgat tcagaactca aaaggaggcg
     2821 gacttgcttc tggtttctct tcatctaacg ccatcatggg cgtgcgcaag actacagatt
     2881 ttctggaaaa agcaacatgg ggcttagcta tcttcatggt ggtaatgagc attgctactg
     2941 cttatgtagt tcctcgctct gctgttgcta aagacgcagt gttggaacag gcacagaaag
     3001 aacaacagac taacccgtat aacttacccg caggtacggc tgcgccgcaa actgaagctc
     3061 ctgctaccaa tgcacctgct acagaaactc cggcaccggc tgctgaaact cctgctcctg
     3121 cagcagagta attcactctg tcgtcaggta agactttggg gtaaaaccat taatgggaag
     3181 gtgcagacgg atgctgcatt tctttgatat ttaagtgcgg attacgcaga ttacacggat
     3241 tttcaatctt ccgcgtggtc agtgtaatcc gcacttaact ttttcttgta aaaacaatct
     3301 ctttgtgata gaaacaaacg agatttaact acctttgttg gtcgtatgaa gattattaac
     3361 tactattttt aaatataaca atgacagaac atttgaaaca aaaattgaat gactccgccg
     3421 tactccgatg gagtgttcta gcattagtcg catttactat gctatgcggc tatttcctca
     3481 ccgacgtaat gtctcctcta aaacccatgc ttgagaaaga actactatgg gacagtctgg
     3541 attatggttt cttcacaagc gcttacggat ggtttaatgt attcctattg atgctgatct
     3601 tcggtggtat cattttggat aagatgggag ttcgtttcac cggaatggga gcttgcttat
     3661 tgatggtgtt tggttgtgga ttgaaatact atgcgatttc tactactttt ccggaaggtg
     3721 ccatgctctt tggattcaaa acacaggtaa ccctggccgc attggggtat gctatcttcg
     3781 gtgtaggtgt ggaaattgcc ggtatcacag tttccaagat tatcgtgaaa tggttcaagg
     3841 gtaaggaaat ggcattagct atgggacttg aaatggctac ggcacgtatc ggaacaactc
     3901 tggcaatggt gcttacggtt cctttggccg actttttcgg atctacggat gagagtggca
     3961 cattccatac caatattcct gctccgattt tgttttgtct gattatgttg tgcgtgggta
     4021 cgattgcttt cttcctttat actttctatg ataagaagtt ggatgcttct ttggatgcag
     4081 agggattgga accggaagag ccgttccgta tgaaagatat tgtgtatatc attaccaata
     4141 aaggattctg gctgattgca ttactatgtg tattgttcta ctcggctgta ttccccttta
     4201 tcaagtatgc tgccgacttg atggtgcaga agtataatgt agatccgaag ttggcgggaa
     4261 cgattcccgg attgttgccg attggtgcga ttatcctgac tccgttgttc ggctcgcttt
     4321 atgaccgtat cggtaaggga gccacattga tgataatcgg atcagtgatg cttatttttg
     4381 tgcatacgat gtttgctctg cctatactga atatatggtg gtttgctact attatcatga
     4441 ttatattggg atttgccttc tcgttggtgc cttcagctat gtggccgtct gttccgaaga
     4501 ttattccgga aaaacagttg ggtactgcat acgcattgat tttctgggta cagaactggg
     4561 gattgatggg tgttcctttg ttgatcggat gggtgttgaa tacttattgc aaaggtccgg
     4621 tagtagacgg tgcacagact tatgactaca cgttgccgat ggctattttt gctctctttg
     4681 gtgtgcttgc tctgattgtg gctttgatgt tgaaggcaga gaacaagaag aagggatacg
     4741 gtctggaaga ggcgaatatc caaaagtaac taggaaattc aatacctaaa gtgacaaagg
     4801 aattttgtat caaggtgtaa acagaagagt atcagtataa atactctgaa ataaaaaata
     4861 agaagtatgg ctgccaaaga gaaaatcaac ctgttagagg tcattccctg tcgcagtgaa
     4921 catattacag cagaaaggga aggggagaca attgtgctct cctttccccg ttttaaatat
     4981 ccgtggatgc aacgcttcct tgtgccgaaa ggaatgtcga aagaacttca tgtgaaattg
     5041 gaagaacacg gtacggctgt atgggaactg atagatggaa aacgcaatgt tcgtgagatt
     5101 atagaaaaac tcgcagacca ctttcaaaat gaagagggct acgagtcgcg tgtatcggct
     5161 tatctttctc aaatgcagaa agatggactt ataaaactgg tgataccagt cgtataaata
     5221 ggaacttatt attatttatt tgataaatac agcccaaagt atgacggcaa ttgctatcag
     5281 gacccccatg ataataagcg ttccccaaac aaaataattg ctgtctttct ctttcttttt
     5341 ctccgagtcg tggatgatac gttccatttc ttcgggggtg gtgttgggta gtggataagg
     5401 ttcgtttgca cggtttatat gcttcaactt atcgttagca cgttcacgac gtaggcggga
     5461 agcttcccgt ccctctttta ttcggcgtat catgtcgaat gcatgtcctt caccaaccat
     5521 attctttgtt ttttagaagt tcacttcctc atttttctat ttcccttctt ctctgtccac
     5581 tttgagcaat cctcccgtat tcggatcaaa ataaactttg atggtagaat tcttgttgaa
     5641 caaaaccgga gccagatatt ctatcacacc aaattgagta ataggaagct caccttcgta
     5701 aagtttcttt ttaccgtcag tcagtgtaac catagcttgt ccgggtacgt tgtaggcgat
     5761 tccatccaaa tctttcttct tcttatcgtc ttcctgtggt atcttgaccg atttcaggtc
     5821 tttcagactg atataaaacg gagttcctgc caaatcattg ttggcaacta cacctaactt
     5881 cttcgagaag cggaaagcaa cttcattgtt gaattccttg tcaggggtaa ggcggacagt
     5941 gaatgttctc tcttctttgt tgcaggtgcc ggagaacatt tgcgtcatgg cttcttcctg
     6001 tgcattcaga ttgtcgagca taattttaag ctgtgcccca tctgaaggca tattatcagc
     6061 ttgtccgcgc aataaggcat ttttgctttc gcggatatta tagatttctt tagccaccag
     6121 ctcggccatc ttagcggtag agctagccat cagaatctct tcggtcagga attcgcgagg
     6181 attcgctttc ttttggagga ctgcgggggc gggagcaact tttttgcctg cactgctatt
     6241 gctgtaagga acattgatcg ttttcacaat gccatcctct gtcagttcca tgagcggtgc
     6301 tactgtctta tccttcaatt ttacgaaata cgtagtttcg ctgttgggca cacctacgga
     6361 tttcactttt acgctagcca gttcccagta ctcttcaggg tcggcggaga cgttggtcag
     6421 tcgcaggtaa cgatcagcat atttgctgaa ttctccggga gtatagttga ctttgttggc
     6481 ttttatttca agttctattt gggttttggg aagactgtaa accactccat agtcttttcc
     6541 tcgggtaacc cctgtcagta cttcggtttg tgcataggcg gacgttgtca taagtagtcc
     6601 tgctgctata atcaactttt tcatattcgg ttctttttaa ctggttttga aaacaaagtt
     6661 aatgaagtta ttgaaaaaag ggtaacttct taacttttat tcgcttacaa gtcgccatgc
     6721 tgtcggcaga caggtgataa tatcgcttgc gatcattccg atcattcctt gcttcttttg
     6781 agcgacatcg cccgccagtc cgtgaatgta agtgccgatt tttgcggctt cctcggttgg
     6841 gtaaccttgg gcaagtagtg ccaggattac tccggtcagt acgtcaccgc tacctccggt
     6901 tgccattccc ggatttccgg ttgggttgaa gaaacattta ccttcggggg tgatgatggc
     6961 ggagtaggct ccttttaaaa taatgtgaac atgggcggca cgggccagtt cgcaagcctt
     7021 catcagacgt tcgtaagagt cctggcattt gccggtcaga cgttccagtt ctttcggatg
     7081 cggggtgagg atggaaccct tcggcaggtg ggtaagggca tggcggtggt tggcaaggat
     7141 attaagtgcg tcggcatcca ccacaacagg agtctggcag tgttccagtt gttccaacaa
     7201 ggcagcttcc gtttcctcgt ttcgtcccag tcccggaccg atgccgactg cttgatagtc
     7261 gtccgtgtcg gtaggtacgg caaaacaggt ttcgttgatg tcggtttcta cgattgcttc
     7321 gggtatggag gtttgcaaga tgtcgttgtt gcacattggc gcatggacag tcagtaaccc
     7381 tactcccgaa cggaggcagg cgcgggcagc aagaacagag gctcctgcca ttccttttga
     7441 accggcaatc aatagtgcat ggccgaagtt ccccttgtgg gcaaactgtt tgcgtggctt
     7501 gatgagtgaa cggatttgct ctatttccaa catttcgtag ttcgtttcca tctcttcaat
     7561 accgtcttcg cttaattgga tgtccagcac ttcccattct ccgacaaatt ccgtgttctc
     7621 tgcgaaaaga aaggcgagct tcggcagttg cagactgaaa gttacgtcgg cacggataat
     7681 attagctttt acgttgaatg tattttcttc tcccatcagt ccggaaggaa tgtcgatggc
     7741 tactaccata gtaggggagg aattgatgta ttttactacg gcagcgaatc cgccgctcaa
     7801 cggtttgttc aggcctgaac cgaataatcc gtcgattacc agatggtcgg gcgtcagggc
     7861 gggaggtacg aattgggtac tgatctcgtg gaattttact tcttccatca tttctaccag
     7921 ttctttattg gtctggcagt cgggtgaaag ttctcctttc gtgttgaaga gaaatacctc
     7981 gattttatat cctttttcag ccatcatgcg ggctacggcg agagcgtctc cgccattatt
     8041 ccccggtccg gcaaagatag tgaccggcgt ttccgtattc catctgtctg tgatggcttt
     8101 tgttaatacg gttgctgcac gttccatcag atcgattgat gcaataggtt cgttctcaat
     8161 ggtataagcg tccaatttct tgatactgct gcttggaaat attttcattg cgatgttctt
     8221 ttagttttcg gattacaaat gtacatgatt cttctgactt ttcccgtttg ttgtgggaag
     8281 aaaaccataa ttgcaacttt taattcatca ttagttctat cttttggtca gagaaatatc
     8341 tgtttttgaa ctattaagtg ttagaataac tccgccaaaa aataattcaa tgcagcacca
     8401 ttatgaactt acttttattt ctcctgaaaa agatttcttc atttcatttc tcatattctc
     8461 attgtttttc gataaacgaa agctaatcaa atagatatct tatgagaaac actttttcga
     8521 aacggtattt ctcataagtt ctcccatatt ttggctcaaa agccacctta ttctcatagt
     8581 atttcagggt atttctcata gtcaaaagcc atttgttctt ccttttttct ttcagcctgc
     8641 cttattttta tcaggaaatg aagctactat ttagataaaa tagtggcttt ttgcttgaag
     8701 atgctcattg gtctcgattg tcccatatat tgtgggaaag ttttccttca atatacagga
     8761 atactttccc acaaaataag ggaatacttt cccaagcctt agggaatctt ttcccacaat
     8821 atgtggaact aagacactgt gtatggaagc aagcaaaagg aatacatagt tttatttatt
     8881 caatgtcagc ttccggcaca ctacactatg agaaatgaag caaaatccgg gttattttgc
     8941 gaagaaacta tgagaaatgc ctgtttttaa atcatttctc atagtctatc ttattagttt
     9001 actgccactt gtttcttatt tatgagaata tgagaaatga aaaatctttt tctgtagagg
     9061 cgcggatgga aattgtgttt agtttatcgc cataccttct taaacaaatt tttaatgcgg
     9121 ttccccttat taagcctttg attatttgcc gtttccgata aaaatgttat ctttggagat
     9181 agataatgtg catcacatta ttttccagtg ctcacaatga aaatgaatta aaatctaaat
     9241 aacggattgt ttaatcttct aaagtttgca tgatggaaaa gacaaaaatt ggcttgaatg
     9301 ccgggaaagt atggcgcatc ttaaatgaaa aaggtgaact ttcaatgttc gatttgtgcc
     9361 gtgaattaag tttgacgttt gaagacgtag ctcttgctat tggttggctg gcccgagaag
     9421 acaaaatctt tttgaggaaa agagaaggaa tgctttttgc cagtatcgaa aatgtcgaat
     9481 ttacttttgg ctaaggtggt agctaaccta catttaagat ggatctccac tttattattt
     9541 acactgctaa aaaagtaatg aagtggatca gtaggatttt ttatgctcgt ttttactatt
     9601 ccccctatta ttctgtttga taagagaagc atctaatcta ctttttctgt acctttgcac
     9661 cccataaact actaaacaca taaattcatg agtgcattga aagggcatcc gaaaggcctt
     9721 tatctgattt tcgcgacaag cacggcagaa cgtttcagtt attacggtat gcgtgcgatc
     9781 tttattcttt tcctgacgca ggcattattg tttgacaaag aagcggcagc atccatctac
     9841 ggcagctata ccggactagt ttatttaacc ccgttgattg gcggatacat tgccgataaa
     9901 tattggggaa tccgtcgttc cgtgttttgg ggagcggtga tgatggcagt cgggcaattc
     9961 ctgatgttta tgagtgcctc cactttagat aatacaaacc ttgcccactg gatgatgtat
    10021 ggcggactag gcttcctgat cttgggcaat ggttgcttca aacccactgt ctcttctctg
    10081 gtaggtcagc tctacgaacc cggagacagg cggttggatg ctgcatacac cattttttat
    10141 atgggagtga atgtaggctc ttttgctgct cctttgattt gtggttatct gggtgatacc
    10201 ggtgatccgc atgactttaa atggggattt cttgcagccg gaatcatgac actgttcacc
    10261 gttgttcttt tcgagactca aaagaataaa tatctttttt ctccttccgg agaaccgatt
    10321 ggtattatcc ccgatgctaa acgtgaaaag aaagaagaca aggccgacca tatctcacac
    10381 ccgaagatgg acaaacgtac caaagtacgt aatacccttg taatcacaat tcttaccatt
    10441 gctttaatag ccttctttaa ctatgcattt gaaggcgatt gggtgagtat cggtattttt
    10501 accgcctgca ttgttttccc tgttctgatc ttgttagacg gttcattgac aaaaatagaa
    10561 cgcagccgta ttttcgttat ctatatagta gccttctttg tcatcttctt ctgggcagcc
    10621 tacgaacagg cgggagcttc tttaactctc tttgcgtccg aacagacgaa tcgtgacatt
    10681 ttcggttggg aaatgccggc ttcatggttt caatccttca atccactgtt tgtagttgtc
    10741 ctggcatata tcatgccggg tgtatggggt ttcctgaaca agcgaaagat ggaacctgct
    10801 tctcctacca aacaagcgat tggtctgtta ctcctttctt taggttatct tttcatctgt
    10861 ttcggagtga aagatgcagt tcccggagtg aaagtgagca tgatttggtt gacaggactt
    10921 tactttattc ataccatggg tgaaatagct ttgtcgccta tcggactttc aatggtaaat
    10981 aaattgagtc cgctgcgttt cgcctccctg atgatgggaa tctggtatct gtctactgcc
    11041 acagccaata aatttgcggg aatgttgagc gggctctatc cggaagccgg aaaagtgaag
    11101 tcaatctttg gttatcagat tgctaccatg tatgatttct ttatggtatt cgtcgtgatg
    11161 tccggtgttg cttcgttgat tctgttcctt ctctcgaaga aattacagaa gatgatgcac
    11221 ggggtagaat aaaaaatcgt atttttgcaa ggttattttt aaattaccgg ttatggatac
    11281 cattcagata aaagacaaat tgtttaccgt ttccattaag gaacaagaaa ttcagaaaga
    11341 agtgattcgc gtagcgaacg aaatcaaccg cgatttggca ggtaagaatc cgcttttcct
    11401 tagtgtgttg aacggttcgt tcatgtttac cgctgattta ctgaagcaca tcaccatccc
    11461 ttgtgaaatc tcatttgtga agttggcgtc ttatcagggc atcacttcca ccggagtgat
    11521 taaagaggta atcggcctga atgaagacat tgccggacgt accattgtga tcgtggaaga
    11581 tatcgtagac acaggactga cgatgcagcg actgctcgaa acattaggta cacgcaatcc
    11641 tgaagctatt catatcgctt ctctgttggt aaaacctgaa aagctcaagg taaacctcaa
    11701 cattgaatat gtagcgatgg aaatcccgaa cgactttatc gtaggttacg gactggatta
    11761 tgatggtttc ggacgtaatt atcccgatat ttatacagta gtagattaat attaaatagg
    11821 taccagttta aatggtaaat agtaaatcgt taaattgtaa ataacaaaat gttgaacatc
    11881 gtaattttcg gtgctccggg ttcaggaaaa ggaacacaga gcgaacgtat cgtagaaaag
    11941 tatggaatca atcacatctc gacaggagat gtattgcgtg ctgaaatcaa gaatggcaca
    12001 gaactgggta aaacagctaa aggttatatc gaccaaggtc aattgattcc tgatgaatta
    12061 atgattgata ttctggcaag cgtattcgac agcttcaaag atagcaaagg ggtaattttc
    12121 gacggtttcc caagaacaat tgcacaagca gaagcattaa agaaaatgtt ggcagaaaga
    12181 ggacaggacg tttctgtaat ggttgacttg gatgttccgg aagaagaact gatggtacgt
    12241 ctcattaaac gtggcaagga ttccggtcgt gctgatgata acgaagaaac aatcaagaaa
    12301 cgtctgcatg tatatcattc acagactgct ccactgatcg actggtacaa gaacgaaaag
    12361 aaataccaac acatcaacgg cttgggtact atggaaggta tcttcgctga aatctgcgaa
    12421 gcagtagata aattgtaata atacgatatt ataaataaat aagtcagtag ccggagtgtt
    12481 ttaattaact gctctaacta ctgactactt taactcttta aaaaaatatg gctgaatcga
    12541 attttgttga ttacgtaaag atatactgtc gctcgggcaa gggcggaaga ggctctacgc
    12601 acatgaggcg cgagaaatat tgtcctaacg gaggtcctga tgggggcgat ggtggaagag
    12661 gaggtcatat catcttgcgc ggtaaccgta attactggac attgctgcac ttgaagtatg
    12721 accgtcatgc aatggccggt catggtgaat cggggagcaa aggacgtagt ttcggaaaag
    12781 acggtgcgga taaaataata gaagtaccct gcggaacggt agtttataat gccgagacag
    12841 gggagtatct ttgtgacgta acagaagacg gacaggaagt ggtcttgctc aaaggcggcc
    12901 gcggcggtca gggtaactgg catttcaaga cggccacccg tcaggctccg cgttttgcgc
    12961 agccgggaga gccgatgcag gaaatgaccg ttatcatgga gctgaaactg cttgccgatg
    13021 tcggtctggt aggtttaccg aatgcgggaa agtcaacttt gctttcttcc atttcggctg
    13081 ccaaaccgaa aattgccgat tacccgttta ctacgctcga acccaacttg ggcatcgttt
    13141 cctatcacgg tggaaaatcc tttgtgatgg cggacatacc gggtattatc gaaggtgcca
    13201 gccaggggaa aggtttggga ctgcgtttct tgcgtcatat cgaacgtaat tcattactgc
    13261 tgtttatggt tccggcagac agcgacgaca ttcgtaaaga atacgaagtc ttgctgaacg
    13321 aactgcgtac cttcaatcct gaaatgttgg acaagcaacg tgtgttggct gtcaccaaga
    13381 gcgatatgct cgatcaggag ttgatggacg agattgaacc tacattgccg gaaggcattc
    13441 cacatgtatt catatcttct gtttccggtt tgggcatctc ggtgttgaaa gacatccttt
    13501 gggaagaact gaacaaggaa agcaataaga tagaggacat cgttcaccgt ccgaaagacg
    13561 tgacccgtct gcaacaggaa ctcaaagaca tgggcgaaga tgaagacatc gtttatgaat
    13621 atgaggaaga tgtcgacgat gacgatgata tcgattatga atacgaagaa gaagattggg
    13681 aagaaaaatg atttcactta caaaatataa cgagttgaag ggatataagt cactggaggc
    13741 atatcccgaa gtagctcatt ttgtaactac gcgtcacgaa ggtataagca ccggagctta
    13801 cagctctttc aactgttcgc cttataccaa cgactcatgc atgaacgtca atcgtaatca
    13861 gagctggttg tttcagtgca tgaatcatca gataaaggaa ttatttattc ctgaacagaa
    13921 tcatggctgt gccagtctga ttatcaatga atcatttttt aaagaatcat tggaaatgag
    13981 acggctactt ctgcgaggaa tggatgcctt gataactaat gtgccgggat attgcgtttg
    14041 tgtcacgacg gcggattgtg ttcctgtatt gctgtacgac aaaaaacaac acgttgtggc
    14101 tgccgttcat gccggatgga agggaacggt gaagcatatt gtcagtaatg tgatggacca
    14161 cttgaataag atgttcggga cgcaaggcga agatgtgata gcttgcatcg ggccgagcat
    14221 ttcgctcgaa tcatttgaag taggtgatga ggtgtatgat gcttttgaag aaagcggctt
    14281 cgatatgtct cttatttcta tgaaaaagaa agaaacaggc aaatatcata ttgatttgtg
    14341 ggaagctaac cggattgaat tactgaatct cggagtgcct gcagaacaga tagaagtggc
    14401 cggaatctgt acctatattc atcatgatga attcttctct gcacgtagac tgggaataga
    14461 ttccggtcgt acattgtcgg gaataatgat tagaaagtaa taattggtgt ccgtaatcgc
    14521 aggacgctga tgattggttt atgataagtt atgtttgaaa taaaagtatc taaagaaata
    14581 aaagacgcat gcccggtttt tgccggagcc gccgtgtatg ctgcagtgaa aaatacagct
    14641 tacagcgaag ggctttggca ggagatcgac gcttttacta ggcaactgac ttccacaaca
    14701 cagatggaag acatcaaaca tcaacccgtt atctttgcta cccgtgaggc ttataaacgt
    14761 tgtggcaaag accccggacg ttaccgcccg tcagccgaag ctctacgccg ccgcctgatg
    14821 cgtggaattc ctttatatca gattgatacg ttggtagacc ttatcaacct tgtgtctctt
    14881 cgcacaggac attcgatcgg tggttttgac gcggacaaaa tacaaggtac gcaccttgaa
    14941 ctcggtatcg gcaaagcagg agaaccgttt gaaggtatcg gacgcggtgt attgaatatc
    15001 gaaggattac ctgtatatcg cgattctttc ggaggaatcg gaaccccgac aagcgaccat
    15061 gaacgtacga agatggacct cggaactact catatcctag ccatagtcaa tggttataac
    15121 ggaaaagaag gtttgcaaga agctgttgaa atgatacaga ccttattaag aaactataca
    15181 gaatcggatg gaggcgaaat cgcattcttc gaataat
//
