LOCUS       gnlProkkaGEKEEBPK_129  15219 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|GEKEEBPK_129.
ACCESSION   gnlProkkaGEKEEBPK_129
VERSION     gnlProkkaGEKEEBPK_129
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2024-11-17 03:55:33
            Original ID  :: gnl|Prokka|GEKEEBPK_129
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 20593
            Orig. end    :: 35812
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..15219
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="True"
                     /core_location="[10000:10231]"
                     /cutoff="10000"
                     /detection_rule="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /neighbourhood="10000"
                     /product="RRE-containing"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..10231
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /neighbourhood="10000"
                     /product="RRE-containing"
                     /protocluster_number="1"
     cand_cluster    1..15219
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /kind="single"
                     /product="RRE-containing"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..15219
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="RRE-containing"
                     /region_number="1"
                     /rules="minimum(1, [Bottromycin_Methyltransferase_RRE,
                     Cyanobactin_D_RRE, Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /tool="antismash"
     CDS             complement(2..667)
                     /locus_tag="ctg129_18"
                     /transl_table=11
                     /translation="MFEIKVSKEIKDACPVFAGAAVYAAVKNTAYSEGLWQEIDAFTRQ
                     LTSTTQMEDIKHQPVIFATREAYKRCGKDPGRYRPSAEALRRRLMRGIPLYQIDTLVDL
                     INLVSLRTGHSIGGFDADKIQGTHLELGIGKAGEPFEGIGRGVLNIEGLPVYRDSFGGI
                     GTPTSDHERTKMDLGTTHILAIVNGYNGKEGLQEAVEMIQTLLRNYTESDGGEIAFFE"
     CDS             complement(718..1530)
                     /locus_tag="ctg129_19"
                     /transl_table=11
                     /translation="MISLTKYNELKGYKSLEAYPEVAHFVTTRHEGISTGAYSSFNCSP
                     YTNDSCMNVNRNQSWLFQCMNHQIKELFIPEQNHGCASLIINESFFKESLEMRRLLLRG
                     MDALITNVPGYCVCVTTADCVPVLLYDKKQHVVAAVHAGWKGTVKHIVSNVMDHLNKMF
                     GTQGEDVIACIGPSISLESFEVGDEVYDAFEESGFDMSLISMKKKETGKYHIDLWEANR
                     IELLNLGVPAEQIEVAGICTYIHHDEFFSARRLGIDSGRTLSGIMIRK"
     CDS             complement(1527..2690)
                     /locus_tag="ctg129_20"
                     /transl_table=11
                     /translation="MAESNFVDYVKIYCRSGKGGRGSTHMRREKYCPNGGPDGGDGGRG
                     GHIILRGNRNYWTLLHLKYDRHAMAGHGESGSKGRSFGKDGADKIIEVPCGTVVYNAET
                     GEYLCDVTEDGQEVVLLKGGRGGQGNWHFKTATRQAPRFAQPGEPMQEMTVIMELKLLA
                     DVGLVGLPNAGKSTLLSSISAAKPKIADYPFTTLEPNLGIVSYHGGKSFVMADIPGIIE
                     GASQGKGLGLRFLRHIERNSLLLFMVPADSDDIRKEYEVLLNELRTFNPEMLDKQRVLA
                     VTKSDMLDQELMDEIEPTLPEGIPHVFISSVSGLGISVLKDILWEELNKESNKIEDIVH
                     RPKDVTRLQQELKDMGEDEDIVYEYEEDVDDDDDIDYEYEEEDWEEK"
     CDS             complement(2780..3349)
                     /locus_tag="ctg129_21"
                     /transl_table=11
                     /translation="MLNIVIFGAPGSGKGTQSERIVEKYGINHISTGDVLRAEIKNGTE
                     LGKTAKGYIDQGQLIPDELMIDILASVFDSFKDSKGVIFDGFPRTIAQAEALKKMLAER
                     GQDVSVMVDLDVPEEELMVRLIKRGKDSGRADDNEETIKKRLHVYHSQTAPLIDWYKNE
                     KKYQHINGLGTMEGIFAEICEAVDKL"
     CDS             complement(3409..3945)
                     /locus_tag="ctg129_22"
                     /transl_table=11
                     /translation="MDTIQIKDKLFTVSIKEQEIQKEVIRVANEINRDLAGKNPLFLSV
                     LNGSFMFTADLLKHITIPCEISFVKLASYQGITSTGVIKEVIGLNEDIAGRTIVIVEDI
                     VDTGLTMQRLLETLGTRNPEAIHIASLLVKPEKLKVNLNIEYVAMEIPNDFIVGYGLDY
                     DGFGRNYPDIYTVVD"
     CDS             complement(3986..5530)
                     /gene_functions="transport (smcogs) SMCOG1202:major
                     facilitator transporter (Score: 46.8; E-value: 2.5e-14)"
                     /gene_kind="transport"
                     /locus_tag="ctg129_23"
                     /transl_table=11
                     /translation="MSALKGHPKGLYLIFATSTAERFSYYGMRAIFILFLTQALLFDKE
                     AAASIYGSYTGLVYLTPLIGGYIADKYWGIRRSVFWGAVMMAVGQFLMFMSASTLDNTN
                     LAHWMMYGGLGFLILGNGCFKPTVSSLVGQLYEPGDRRLDAAYTIFYMGVNVGSFAAPL
                     ICGYLGDTGDPHDFKWGFLAAGIMTLFTVVLFETQKNKYLFSPSGEPIGIIPDAKREKK
                     EDKADHISHPKMDKRTKVRNTLVITILTIALIAFFNYAFEGDWVSIGIFTACIVFPVLI
                     LLDGSLTKIERSRIFVIYIVAFFVIFFWAAYEQAGASLTLFASEQTNRDIFGWEMPASW
                     FQSFNPLFVVVLAYIMPGVWGFLNKRKMEPASPTKQAIGLLLLSLGYLFICFGVKDAVP
                     GVKVSMIWLTGLYFIHTMGEIALSPIGLSMVNKLSPLRFASLMMGIWYLSTATANKFAG
                     MLSGLYPEAGKVKSIFGYQIATMYDFFMVFVVMSGVASLILFLLSKKLQKMMHGVE"
     CDS             complement(5724..5948)
                     /locus_tag="ctg129_24"
                     /transl_table=11
                     /translation="MMEKTKIGLNAGKVWRILNEKGELSMFDLCRELSLTFEDVALAIG
                     WLAREDKIFLRKREGMLFASIENVEFTFG"
     CDS             7010..8521
                     /locus_tag="ctg129_25"
                     /transl_table=11
                     /translation="MKIFPSSSIKKLDAYTIENEPIASIDLMERAATVLTKAITDRWNT
                     ETPVTIFAGPGNNGGDALAVARMMAEKGYKIEVFLFNTKGELSPDCQTNKELVEMMEEV
                     KFHEISTQFVPPALTPDHLVIDGLFGSGLNKPLSGGFAAVVKYINSSPTMVVAIDIPSG
                     LMGEENTFNVKANIIRADVTFSLQLPKLAFLFAENTEFVGEWEVLDIQLSEDGIEEMET
                     NYEMLEIEQIRSLIKPRKQFAHKGNFGHALLIAGSKGMAGASVLAARACLRSGVGLLTV
                     HAPMCNNDILQTSIPEAIVETDINETCFAVPTDTDDYQAVGIGPGLGRNEETEAALLEQ
                     LEHCQTPVVVDADALNILANHRHALTHLPKGSILTPHPKELERLTGKCQDSYERLMKAC
                     ELARAAHVHIILKGAYSAIITPEGKCFFNPTGNPGMATGGSGDVLTGVILALLAQGYPT
                     EEAAKIGTYIHGLAGDVAQKKQGMIGMIASDIITCLPTAWRLVSE"
     CDS             8594..9661
                     /locus_tag="ctg129_26"
                     /transl_table=11
                     /translation="MKKLIIAAGLLMTTSAYAQTEVLTGVTRGKDYGVVYSLPKTQIEL
                     EIKANKVNYTPGEFSKYADRYLRLTNVSADPEEYWELASVKVKSVGVPNSETTYFVKLK
                     DKTVAPLMELTEDGIVKTINVPYSNSSAGKKVAPAPAVLQKKANPREFLTEEILMASST
                     AKMAELVAKEIYNIRESKNALLRGQADNMPSDGAQLKIMLDNLNAQEEAMTQMFSGTCN
                     KEERTFTVRLTPDKEFNNEVAFRFSKKLGVVANNDLAGTPFYISLKDLKSVKIPQEDDK
                     KKKDLDGIAYNVPGQAMVTLTDGKKKLYEGELPITQFGVIEYLAPVLFNKNSTIKVYFD
                     PNTGGLLKVDREEGK"
     CDS             complement(10001..10231)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RRE-containing: PqqD_RRE"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RRE-containing: Stand_Alone_Lasso_RRE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF05402"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg129_27"
                     /sec_met_domain="PqqD_RRE (E-value: 1.2e-11, bitscore:
                     35.4, seeds: 9, tool: rule-based-clusters)"
                     /sec_met_domain="PF05402 (E-value: 5.1e-18, bitscore: 56.3,
                     seeds: 461, tool: rule-based-clusters)"
                     /sec_met_domain="Stand_Alone_Lasso_RRE (E-value: 2.1e-08,
                     bitscore: 25.3, seeds: 25, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MQRFLVPKGMSKELHVKLEEHGTAVWELIDGKRNVREIIEKLADH
                     FQNEEGYESRVSAYLSQMQKDGLIKLVIPVV"
     CDS             complement(10449..11837)
                     /gene_functions="transport (smcogs) SMCOG1106:major
                     facilitator transporter (Score: 92.3; E-value: 4e-28)"
                     /gene_kind="transport"
                     /locus_tag="ctg129_28"
                     /transl_table=11
                     /translation="MTEHLKQKLNDSAVLRWSVLALVAFTMLCGYFLTDVMSPLKPMLE
                     KELLWDSLDYGFFTSAYGWFNVFLLMLIFGGIILDKMGVRFTGMGACLLMVFGCGLKYY
                     AISTTFPEGAMLFGFKTQVTLAALGYAIFGVGVEIAGITVSKIIVKWFKGKEMALAMGL
                     EMATARIGTTLAMVLTVPLADFFGSTDESGTFHTNIPAPILFCLIMLCVGTIAFFLYTF
                     YDKKLDASLDAEGLEPEEPFRMKDIVYIITNKGFWLIALLCVLFYSAVFPFIKYAADLM
                     VQKYNVDPKLAGTIPGLLPIGAIILTPLFGSLYDRIGKGATLMIIGSVMLIFVHTMFAL
                     PILNIWWFATIIMIILGFAFSLVPSAMWPSVPKIIPEKQLGTAYALIFWVQNWGLMGVP
                     LLIGWVLNTYCKGPVVDGAQTYDYTLPMAIFALFGVLALIVALMLKAENKKKGYGLEEA
                     NIQK"
     CDS             complement(12087..12482)
                     /locus_tag="ctg129_29"
                     /transl_table=11
                     /translation="MYLLFVILMVIAALLMCFIVLIQNSKGGGLASGFSSSNAIMGVRK
                     TTDFLEKATWGLAIFMVVMSIATAYVVPRSAVAKDAVLEQAQKEQQTNPYNLPAGTAAP
                     QTEAPATNAPATETPAPAAETPAPAAE"
     CDS             complement(12489..13262)
                     /locus_tag="ctg129_30"
                     /transl_table=11
                     /translation="MTSVNFQQWIQHPETLNRDTLYELRNLLARYPYFQSLRLLYLKNL
                     YILHDISFGGELRKAVLYIADRRQLFRLIEGDRYDVQARKKGIPLTEVLKDEPSVDRTL
                     ALIDAFLSTVPEEVTARTSFDYSMDYTSYLLEETPATEQPAEETPKLKGFELIDDFIEK
                     SESDSPLCMKPLREEMPSSPTSSDELTEEETMKEEEEDDSCFTETLAKIYVKQQRYSKA
                     LEIIKKLSLKYPKKNAYFADQIRFLEKLIINANSK"
     CDS             complement(13268..13795)
                     /locus_tag="ctg129_31"
                     /transl_table=11
                     /translation="MNWIKKIIRPLLLFGLPLVVIACTVSYKFNGSSINYDKVKTISIA
                     DFPIKSEYVYAPLATKFNEDLKDIFIRQTRLQLLKPSQNADLQIDGEITGYNQYNQAVS
                     ADGYSSETKLTITVNVRFVNNTNHAEDFEQQFSAFRTYDSTQLLTAVQDGLIAEMSKEI
                     TDQIFNATVANW"
     CDS             complement(13782..15023)
                     /gene_functions="regulatory (smcogs) SMCOG1112:sigma-54
                     dependent trancsriptional regulator (Score: 385.8; E-value:
                     4.8e-117)"
                     /gene_kind="regulatory"
                     /locus_tag="ctg129_32"
                     /transl_table=11
                     /translation="MTRAEIQQVKQRFGIIGNTEALSRAIDVAIQVAPTDLSVLITGES
                     GVGKESFPQIIHQYSRRKHGQYIAVNCGAIPEGTIDSELFGHEKGAFTGAIGERKGYFG
                     EADGGTIFLDEVGELPMPTQARLLRVLESGEFIKVGSSKVQKTDVRIVAATNVNLTQAI
                     AEGRFREDLYYRLNTVPIQIPPLRERGDDVLLLFRKFSADFAEKYRMPAIQLTEDAKKE
                     LLAYPWPGNVRQLKNITEQISIIETNREISAAILQNYLPAQNTQRLPALMGTRESKGFE
                     SEREILYSVLFDMRQEVAELKKMVHNLMAERAGQVGQVGQVGTVVTTPVVTTHQPSVPA
                     IIHTMQPAVCKDDDDIQDTEEYVEEPPLSLDEVEKEMIRKALERHHGKRKSAAKDLNIS
                     ERTLYRKIKEYELD"
     CDS             complement(15033..15218)
                     /locus_tag="ctg129_33"
                     /transl_table=11
                     /translation="MDIAGKGLACEDSFRQAIYVAIDVFRNRQREKVARANPLRKQYYE
                     KRDDSDKLKLDTVDED"
ORIGIN
        1 attattcgaa gaatgcgatt tcgcctccat ccgattctgt atagtttctt aataaggtct
       61 gtatcatttc aacagcttct tgcaaacctt cttttccgtt ataaccattg actatggcta
      121 ggatatgagt agttccgagg tccatcttcg tacgttcatg gtcgcttgtc ggggttccga
      181 ttcctccgaa agaatcgcga tatacaggta atccttcgat attcaataca ccgcgtccga
      241 taccttcaaa cggttctcct gctttgccga taccgagttc aaggtgcgta ccttgtattt
      301 tgtccgcgtc aaaaccaccg atcgaatgtc ctgtgcgaag agacacaagg ttgataaggt
      361 ctaccaacgt atcaatctga tataaaggaa ttccacgcat caggcggcgg cgtagagctt
      421 cggctgacgg gcggtaacgt ccggggtctt tgccacaacg tttataagcc tcacgggtag
      481 caaagataac gggttgatgt ttgatgtctt ccatctgtgt tgtggaagtc agttgcctag
      541 taaaagcgtc gatctcctgc caaagccctt cgctgtaagc tgtatttttc actgcagcat
      601 acacggcggc tccggcaaaa accgggcatg cgtcttttat ttctttagat acttttattt
      661 caaacataac ttatcataaa ccaatcatca gcgtcctgcg attacggaca ccaattatta
      721 ctttctaatc attattcccg acaatgtacg accggaatct attcccagtc tacgtgcaga
      781 gaagaattca tcatgatgaa tataggtaca gattccggcc acttctatct gttctgcagg
      841 cactccgaga ttcagtaatt caatccggtt agcttcccac aaatcaatat gatatttgcc
      901 tgtttctttc tttttcatag aaataagaga catatcgaag ccgctttctt caaaagcatc
      961 atacacctca tcacctactt caaatgattc gagcgaaatg ctcggcccga tgcaagctat
     1021 cacatcttcg ccttgcgtcc cgaacatctt attcaagtgg tccatcacat tactgacaat
     1081 atgcttcacc gttcccttcc atccggcatg aacggcagcc acaacgtgtt gttttttgtc
     1141 gtacagcaat acaggaacac aatccgccgt cgtgacacaa acgcaatatc ccggcacatt
     1201 agttatcaag gcatccattc ctcgcagaag tagccgtctc atttccaatg attctttaaa
     1261 aaatgattca ttgataatca gactggcaca gccatgattc tgttcaggaa taaataattc
     1321 ctttatctga tgattcatgc actgaaacaa ccagctctga ttacgattga cgttcatgca
     1381 tgagtcgttg gtataaggcg aacagttgaa agagctgtaa gctccggtgc ttataccttc
     1441 gtgacgcgta gttacaaaat gagctacttc gggatatgcc tccagtgact tatatccctt
     1501 caactcgtta tattttgtaa gtgaaatcat ttttcttccc aatcttcttc ttcgtattca
     1561 taatcgatat catcgtcatc gtcgacatct tcctcatatt cataaacgat gtcttcatct
     1621 tcgcccatgt ctttgagttc ctgttgcaga cgggtcacgt ctttcggacg gtgaacgatg
     1681 tcctctatct tattgctttc cttgttcagt tcttcccaaa ggatgtcttt caacaccgag
     1741 atgcccaaac cggaaacaga agatatgaat acatgtggaa tgccttccgg caatgtaggt
     1801 tcaatctcgt ccatcaactc ctgatcgagc atatcgctct tggtgacagc caacacacgt
     1861 tgcttgtcca acatttcagg attgaaggta cgcagttcgt tcagcaagac ttcgtattct
     1921 ttacgaatgt cgtcgctgtc tgccggaacc ataaacagca gtaatgaatt acgttcgata
     1981 tgacgcaaga aacgcagtcc caaacctttc ccctggctgg caccttcgat aatacccggt
     2041 atgtccgcca tcacaaagga ttttccaccg tgataggaaa cgatgcccaa gttgggttcg
     2101 agcgtagtaa acgggtaatc ggcaattttc ggtttggcag ccgaaatgga agaaagcaaa
     2161 gttgactttc ccgcattcgg taaacctacc agaccgacat cggcaagcag tttcagctcc
     2221 atgataacgg tcatttcctg catcggctct cccggctgcg caaaacgcgg agcctgacgg
     2281 gtggccgtct tgaaatgcca gttaccctga ccgccgcggc cgcctttgag caagaccact
     2341 tcctgtccgt cttctgttac gtcacaaaga tactcccctg tctcggcatt ataaactacc
     2401 gttccgcagg gtacttctat tattttatcc gcaccgtctt ttccgaaact acgtcctttg
     2461 ctccccgatt caccatgacc ggccattgca tgacggtcat acttcaagtg cagcaatgtc
     2521 cagtaattac ggttaccgcg caagatgata tgacctcctc ttccaccatc gcccccatca
     2581 ggacctccgt taggacaata tttctcgcgc ctcatgtgcg tagagcctct tccgcccttg
     2641 cccgagcgac agtatatctt tacgtaatca acaaaattcg attcagccat atttttttaa
     2701 agagttaaag tagtcagtag ttagagcagt taattaaaac actccggcta ctgacttatt
     2761 tatttataat atcgtattat tacaatttat ctactgcttc gcagatttca gcgaagatac
     2821 cttccatagt acccaagccg ttgatgtgtt ggtatttctt ttcgttcttg taccagtcga
     2881 tcagtggagc agtctgtgaa tgatatacat gcagacgttt cttgattgtt tcttcgttat
     2941 catcagcacg accggaatcc ttgccacgtt taatgagacg taccatcagt tcttcttccg
     3001 gaacatccaa gtcaaccatt acagaaacgt cctgtcctct ttctgccaac attttcttta
     3061 atgcttctgc ttgtgcaatt gttcttggga aaccgtcgaa aattacccct ttgctatctt
     3121 tgaagctgtc gaatacgctt gccagaatat caatcattaa ttcatcagga atcaattgac
     3181 cttggtcgat ataaccttta gctgttttac ccagttctgt gccattcttg atttcagcac
     3241 gcaatacatc tcctgtcgag atgtgattga ttccatactt ttctacgata cgttcgctct
     3301 gtgttccttt tcctgaaccc ggagcaccga aaattacgat gttcaacatt ttgttattta
     3361 caatttaacg atttactatt taccatttaa actggtacct atttaatatt aatctactac
     3421 tgtataaata tcgggataat tacgtccgaa accatcataa tccagtccgt aacctacgat
     3481 aaagtcgttc gggatttcca tcgctacata ttcaatgttg aggtttacct tgagcttttc
     3541 aggttttacc aacagagaag cgatatgaat agcttcagga ttgcgtgtac ctaatgtttc
     3601 gagcagtcgc tgcatcgtca gtcctgtgtc tacgatatct tccacgatca caatggtacg
     3661 tccggcaatg tcttcattca ggccgattac ctctttaatc actccggtgg aagtgatgcc
     3721 ctgataagac gccaacttca caaatgagat ttcacaaggg atggtgatgt gcttcagtaa
     3781 atcagcggta aacatgaacg aaccgttcaa cacactaagg aaaagcggat tcttacctgc
     3841 caaatcgcgg ttgatttcgt tcgctacgcg aatcacttct ttctgaattt cttgttcctt
     3901 aatggaaacg gtaaacaatt tgtcttttat ctgaatggta tccataaccg gtaatttaaa
     3961 aataaccttg caaaaatacg attttttatt ctaccccgtg catcatcttc tgtaatttct
     4021 tcgagagaag gaacagaatc aacgaagcaa caccggacat cacgacgaat accataaaga
     4081 aatcatacat ggtagcaatc tgataaccaa agattgactt cacttttccg gcttccggat
     4141 agagcccgct caacattccc gcaaatttat tggctgtggc agtagacaga taccagattc
     4201 ccatcatcag ggaggcgaaa cgcagcggac tcaatttatt taccattgaa agtccgatag
     4261 gcgacaaagc tatttcaccc atggtatgaa taaagtaaag tcctgtcaac caaatcatgc
     4321 tcactttcac tccgggaact gcatctttca ctccgaaaca gatgaaaaga taacctaaag
     4381 aaaggagtaa cagaccaatc gcttgtttgg taggagaagc aggttccatc tttcgcttgt
     4441 tcaggaaacc ccatacaccc ggcatgatat atgccaggac aactacaaac agtggattga
     4501 aggattgaaa ccatgaagcc ggcatttccc aaccgaaaat gtcacgattc gtctgttcgg
     4561 acgcaaagag agttaaagaa gctcccgcct gttcgtaggc tgcccagaag aagatgacaa
     4621 agaaggctac tatatagata acgaaaatac ggctgcgttc tatttttgtc aatgaaccgt
     4681 ctaacaagat cagaacaggg aaaacaatgc aggcggtaaa aataccgata ctcacccaat
     4741 cgccttcaaa tgcatagtta aagaaggcta ttaaagcaat ggtaagaatt gtgattacaa
     4801 gggtattacg tactttggta cgtttgtcca tcttcgggtg tgagatatgg tcggccttgt
     4861 cttctttctt ttcacgttta gcatcgggga taataccaat cggttctccg gaaggagaaa
     4921 aaagatattt attcttttga gtctcgaaaa gaacaacggt gaacagtgtc atgattccgg
     4981 ctgcaagaaa tccccattta aagtcatgcg gatcaccggt atcacccaga taaccacaaa
     5041 tcaaaggagc agcaaaagag cctacattca ctcccatata aaaaatggtg tatgcagcat
     5101 ccaaccgcct gtctccgggt tcgtagagct gacctaccag agaagagaca gtgggtttga
     5161 agcaaccatt gcccaagatc aggaagccta gtccgccata catcatccag tgggcaaggt
     5221 ttgtattatc taaagtggag gcactcataa acatcaggaa ttgcccgact gccatcatca
     5281 ccgctcccca aaacacggaa cgacggattc cccaatattt atcggcaatg tatccgccaa
     5341 tcaacggggt taaataaact agtccggtat agctgccgta gatggatgct gccgcttctt
     5401 tgtcaaacaa taatgcctgc gtcaggaaaa gaataaagat cgcacgcata ccgtaataac
     5461 tgaaacgttc tgccgtgctt gtcgcgaaaa tcagataaag gcctttcgga tgccctttca
     5521 atgcactcat gaatttatgt gtttagtagt ttatggggtg caaaggtaca gaaaaagtag
     5581 attagatgct tctcttatca aacagaataa tagggggaat agtaaaaacg agcataaaaa
     5641 atcctactga tccacttcat tactttttta gcagtgtaaa taataaagtg gagatccatc
     5701 ttaaatgtag gttagctacc accttagcca aaagtaaatt cgacattttc gatactggca
     5761 aaaagcattc cttctctttt cctcaaaaag attttgtctt ctcgggccag ccaaccaata
     5821 gcaagagcta cgtcttcaaa cgtcaaactt aattcacggc acaaatcgaa cattgaaagt
     5881 tcaccttttt catttaagat gcgccatact ttcccggcat tcaagccaat ttttgtcttt
     5941 tccatcatgc aaactttaga agattaaaca atccgttatt tagattttaa ttcattttca
     6001 ttgtgagcac tggaaaataa tgtgatgcac attatctatc tccaaagata acatttttat
     6061 cggaaacggc aaataatcaa aggcttaata aggggaaccg cattaaaaat ttgtttaaga
     6121 aggtatggcg ataaactaaa cacaatttcc atccgcgcct ctacagaaaa agatttttca
     6181 tttctcatat tctcataaat aagaaacaag tggcagtaaa ctaataagat agactatgag
     6241 aaatgattta aaaacaggca tttctcatag tttcttcgca aaataacccg gattttgctt
     6301 catttctcat agtgtagtgt gccggaagct gacattgaat aaataaaact atgtattcct
     6361 tttgcttgct tccatacaca gtgtcttagt tccacatatt gtgggaaaag attccctaag
     6421 gcttgggaaa gtattccctt attttgtggg aaagtattcc tgtatattga aggaaaactt
     6481 tcccacaata tatgggacaa tcgagaccaa tgagcatctt caagcaaaaa gccactattt
     6541 tatctaaata gtagcttcat ttcctgataa aaataaggca ggctgaaaga aaaaaggaag
     6601 aacaaatggc ttttgactat gagaaatacc ctgaaatact atgagaataa ggtggctttt
     6661 gagccaaaat atgggagaac ttatgagaaa taccgtttcg aaaaagtgtt tctcataaga
     6721 tatctatttg attagctttc gtttatcgaa aaacaatgag aatatgagaa atgaaatgaa
     6781 gaaatctttt tcaggagaaa taaaagtaag ttcataatgg tgctgcattg aattattttt
     6841 tggcggagtt attctaacac ttaatagttc aaaaacagat atttctctga ccaaaagata
     6901 gaactaatga tgaattaaaa gttgcaatta tggttttctt cccacaacaa acgggaaaag
     6961 tcagaagaat catgtacatt tgtaatccga aaactaaaag aacatcgcaa tgaaaatatt
     7021 tccaagcagc agtatcaaga aattggacgc ttataccatt gagaacgaac ctattgcatc
     7081 aatcgatctg atggaacgtg cagcaaccgt attaacaaaa gccatcacag acagatggaa
     7141 tacggaaacg ccggtcacta tctttgccgg accggggaat aatggcggag acgctctcgc
     7201 cgtagcccgc atgatggctg aaaaaggata taaaatcgag gtatttctct tcaacacgaa
     7261 aggagaactt tcacccgact gccagaccaa taaagaactg gtagaaatga tggaagaagt
     7321 aaaattccac gagatcagta cccaattcgt acctcccgcc ctgacgcccg accatctggt
     7381 aatcgacgga ttattcggtt caggcctgaa caaaccgttg agcggcggat tcgctgccgt
     7441 agtaaaatac atcaattcct cccctactat ggtagtagcc atcgacattc cttccggact
     7501 gatgggagaa gaaaatacat tcaacgtaaa agctaatatt atccgtgccg acgtaacttt
     7561 cagtctgcaa ctgccgaagc tcgcctttct tttcgcagag aacacggaat ttgtcggaga
     7621 atgggaagtg ctggacatcc aattaagcga agacggtatt gaagagatgg aaacgaacta
     7681 cgaaatgttg gaaatagagc aaatccgttc actcatcaag ccacgcaaac agtttgccca
     7741 caaggggaac ttcggccatg cactattgat tgccggttca aaaggaatgg caggagcctc
     7801 tgttcttgct gcccgcgcct gcctccgttc gggagtaggg ttactgactg tccatgcgcc
     7861 aatgtgcaac aacgacatct tgcaaacctc catacccgaa gcaatcgtag aaaccgacat
     7921 caacgaaacc tgttttgccg tacctaccga cacggacgac tatcaagcag tcggcatcgg
     7981 tccgggactg ggacgaaacg aggaaacgga agctgccttg ttggaacaac tggaacactg
     8041 ccagactcct gttgtggtgg atgccgacgc acttaatatc cttgccaacc accgccatgc
     8101 ccttacccac ctgccgaagg gttccatcct caccccgcat ccgaaagaac tggaacgtct
     8161 gaccggcaaa tgccaggact cttacgaacg tctgatgaag gcttgcgaac tggcccgtgc
     8221 cgcccatgtt cacattattt taaaaggagc ctactccgcc atcatcaccc ccgaaggtaa
     8281 atgtttcttc aacccaaccg gaaatccggg aatggcaacc ggaggtagcg gtgacgtact
     8341 gaccggagta atcctggcac tacttgccca aggttaccca accgaggaag ccgcaaaaat
     8401 cggcacttac attcacggac tggcgggcga tgtcgctcaa aagaagcaag gaatgatcgg
     8461 aatgatcgca agcgatatta tcacctgtct gccgacagca tggcgacttg taagcgaata
     8521 aaagttaaga agttaccctt ttttcaataa cttcattaac tttgttttca aaaccagtta
     8581 aaaagaaccg aatatgaaaa agttgattat agcagcagga ctacttatga caacgtccgc
     8641 ctatgcacaa accgaagtac tgacaggggt tacccgagga aaagactatg gagtggttta
     8701 cagtcttccc aaaacccaaa tagaacttga aataaaagcc aacaaagtca actatactcc
     8761 cggagaattc agcaaatatg ctgatcgtta cctgcgactg accaacgtct ccgccgaccc
     8821 tgaagagtac tgggaactgg ctagcgtaaa agtgaaatcc gtaggtgtgc ccaacagcga
     8881 aactacgtat ttcgtaaaat tgaaggataa gacagtagca ccgctcatgg aactgacaga
     8941 ggatggcatt gtgaaaacga tcaatgttcc ttacagcaat agcagtgcag gcaaaaaagt
     9001 tgctcccgcc cccgcagtcc tccaaaagaa agcgaatcct cgcgaattcc tgaccgaaga
     9061 gattctgatg gctagctcta ccgctaagat ggccgagctg gtggctaaag aaatctataa
     9121 tatccgcgaa agcaaaaatg ccttattgcg cggacaagct gataatatgc cttcagatgg
     9181 ggcacagctt aaaattatgc tcgacaatct gaatgcacag gaagaagcca tgacgcaaat
     9241 gttctccggc acctgcaaca aagaagagag aacattcact gtccgcctta cccctgacaa
     9301 ggaattcaac aatgaagttg ctttccgctt ctcgaagaag ttaggtgtag ttgccaacaa
     9361 tgatttggca ggaactccgt tttatatcag tctgaaagac ctgaaatcgg tcaagatacc
     9421 acaggaagac gataagaaga agaaagattt ggatggaatc gcctacaacg tacccggaca
     9481 agctatggtt acactgactg acggtaaaaa gaaactttac gaaggtgagc ttcctattac
     9541 tcaatttggt gtgatagaat atctggctcc ggttttgttc aacaagaatt ctaccatcaa
     9601 agtttatttt gatccgaata cgggaggatt gctcaaagtg gacagagaag aagggaaata
     9661 gaaaaatgag gaagtgaact tctaaaaaac aaagaatatg gttggtgaag gacatgcatt
     9721 cgacatgata cgccgaataa aagagggacg ggaagcttcc cgcctacgtc gtgaacgtgc
     9781 taacgataag ttgaagcata taaaccgtgc aaacgaacct tatccactac ccaacaccac
     9841 ccccgaagaa atggaacgta tcatccacga ctcggagaaa aagaaagaga aagacagcaa
     9901 ttattttgtt tggggaacgc ttattatcat gggggtcctg atagcaattg ccgtcatact
     9961 ttgggctgta tttatcaaat aaataataat aagttcctat ttatacgact ggtatcacca
    10021 gttttataag tccatctttc tgcatttgag aaagataagc cgatacacgc gactcgtagc
    10081 cctcttcatt ttgaaagtgg tctgcgagtt tttctataat ctcacgaaca ttgcgttttc
    10141 catctatcag ttcccataca gccgtaccgt gttcttccaa tttcacatga agttctttcg
    10201 acattccttt cggcacaagg aagcgttgca tccacggata tttaaaacgg ggaaaggaga
    10261 gcacaattgt ctccccttcc ctttctgctg taatatgttc actgcgacag ggaatgacct
    10321 ctaacaggtt gattttctct ttggcagcca tacttcttat tttttatttc agagtattta
    10381 tactgatact cttctgttta caccttgata caaaattcct ttgtcacttt aggtattgaa
    10441 tttcctagtt acttttggat attcgcctct tccagaccgt atcccttctt cttgttctct
    10501 gccttcaaca tcaaagccac aatcagagca agcacaccaa agagagcaaa aatagccatc
    10561 ggcaacgtgt agtcataagt ctgtgcaccg tctactaccg gacctttgca ataagtattc
    10621 aacacccatc cgatcaacaa aggaacaccc atcaatcccc agttctgtac ccagaaaatc
    10681 aatgcgtatg cagtacccaa ctgtttttcc ggaataatct tcggaacaga cggccacata
    10741 gctgaaggca ccaacgagaa ggcaaatccc aatataatca tgataatagt agcaaaccac
    10801 catatattca gtataggcag agcaaacatc gtatgcacaa aaataagcat cactgatccg
    10861 attatcatca atgtggctcc cttaccgata cggtcataaa gcgagccgaa caacggagtc
    10921 aggataatcg caccaatcgg caacaatccg ggaatcgttc ccgccaactt cggatctaca
    10981 ttatacttct gcaccatcaa gtcggcagca tacttgataa aggggaatac agccgagtag
    11041 aacaatacac atagtaatgc aatcagccag aatcctttat tggtaatgat atacacaata
    11101 tctttcatac ggaacggctc ttccggttcc aatccctctg catccaaaga agcatccaac
    11161 ttcttatcat agaaagtata aaggaagaaa gcaatcgtac ccacgcacaa cataatcaga
    11221 caaaacaaaa tcggagcagg aatattggta tggaatgtgc cactctcatc cgtagatccg
    11281 aaaaagtcgg ccaaaggaac cgtaagcacc attgccagag ttgttccgat acgtgccgta
    11341 gccatttcaa gtcccatagc taatgccatt tccttaccct tgaaccattt cacgataatc
    11401 ttggaaactg tgataccggc aatttccaca cctacaccga agatagcata ccccaatgcg
    11461 gccagggtta cctgtgtttt gaatccaaag agcatggcac cttccggaaa agtagtagaa
    11521 atcgcatagt atttcaatcc acaaccaaac accatcaata agcaagctcc cattccggtg
    11581 aaacgaactc ccatcttatc caaaatgata ccaccgaaga tcagcatcaa taggaataca
    11641 ttaaaccatc cgtaagcgct tgtgaagaaa ccataatcca gactgtccca tagtagttct
    11701 ttctcaagca tgggttttag aggagacatt acgtcggtga ggaaatagcc gcatagcata
    11761 gtaaatgcga ctaatgctag aacactccat cggagtacgg cggagtcatt caatttttgt
    11821 ttcaaatgtt ctgtcattgt tatatttaaa aatagtagtt aataatcttc atacgaccaa
    11881 caaaggtagt taaatctcgt ttgtttctat cacaaagaga ttgtttttac aagaaaaagt
    11941 taagtgcgga ttacactgac cacgcggaag attgaaaatc cgtgtaatct gcgtaatccg
    12001 cacttaaata tcaaagaaat gcagcatccg tctgcacctt cccattaatg gttttacccc
    12061 aaagtcttac ctgacgacag agtgaattac tctgctgcag gagcaggagt ttcagcagcc
    12121 ggtgccggag tttctgtagc aggtgcattg gtagcaggag cttcagtttg cggcgcagcc
    12181 gtacctgcgg gtaagttata cgggttagtc tgttgttctt tctgtgcctg ttccaacact
    12241 gcgtctttag caacagcaga gcgaggaact acataagcag tagcaatgct cattaccacc
    12301 atgaagatag ctaagcccca tgttgctttt tccagaaaat ctgtagtctt gcgcacgccc
    12361 atgatggcgt tagatgaaga gaaaccagaa gcaagtccgc ctccttttga gttctgaatc
    12421 agcacgatga aacacatcaa caaggctgca ataaccatta agataacgaa taataagtac
    12481 atttttagtt attttgaatt agcgttaata atcaatttct ccaaaaatct gatttggtct
    12541 gcaaagtaag catttttttt tggatatttc aagcttaatt ttttaattat ttcaagagct
    12601 tttgaatatc gttgctgttt aacatagatt tttgccaaag tttccgtaaa acagctgtca
    12661 tcttcctctt cttccttcat cgtttcttct tcggtaagtt cgtccgaaga ggttggcgaa
    12721 gatggcattt cttctcttaa aggtttcatg cagaggggag agtcgctctc gctcttttct
    12781 ataaagtcgt caatcagttc gaagcctttg agtttgggcg tttcttcggc cggctgttcc
    12841 gtggctggag tctcctccaa aagataagaa gtgtaatcca tcgaatagtc gaaactggtc
    12901 cgggcagtca cctcttcggg tactgtggac aagaaagcgt cgatcaatgc taatgtgcgg
    12961 tctacggacg gttcgtcttt cagcacctcc gtaagaggta ttcccttttt ccgtgcctgc
    13021 acatcatagc ggtcaccttc aatcaaccgg aacaactgcc gtctgtctgc aatgtaaaga
    13081 actgctttcc gcagttctcc accgaaacta atatcatgga gaatatacag attcttcaga
    13141 tacagcagac gaagtgactg aaaatacgga tacctcgcaa gaagattgcg cagttcgtac
    13201 aaagtatccc tattcagcgt ctcgggatgc tgaatccatt gttgaaagtt aacagaagtc
    13261 atttatatta ccagtttgct acagttgcat taaaaatttg gtcggtgatc tctttagaca
    13321 tttcagcaat caatccgtcc tgtacggcag tcaacaactg ggtagagtcg taggtacgga
    13381 acgcagaaaa ctgttgttca aagtcttcgg catgattggt gttgttgaca aaacgcacat
    13441 tgacggtgat agtcaacttc gtctccgaag aataaccgtc ggcagatact gcctggttgt
    13501 actgattgta ccctgtgatt tctccgtcaa tctgcaagtc ggcattttga ctcggcttga
    13561 gcagttgcag acgggtctgc cggatgaaga tatctttcag gtcctcattg aatttggttg
    13621 ccaacggagc atatacatac tccgacttga tcgggaagtc ggctatcgaa atggtcttta
    13681 ccttatcata attgatagac gatccgttaa acttatagga aacagtgcac gcaatgacta
    13741 ccaacggcaa gccgaacagt agcaaagggc gtattatttt cttaatccaa ttcatattct
    13801 tttatttttc tataaagtgt acgctcggaa atattcaagt ccttggccgc actcttccgc
    13861 tttccgtgat gcctttcaag tgctttgcgt atcatttctt tttccacttc gtccagtgac
    13921 aaaggaggtt cttctacata ttcttccgtg tcttgtatgt cgtcatcatc cttgcaaacc
    13981 gcaggctgca tggtatgaat gatcgcaggt accgaaggct ggtgtgtcgt cactaccgga
    14041 gtagtaacca ccgttcccac ttgtcctacc tgtcccacct gtccggcacg ttccgccatc
    14101 aggttgtgca ccatcttctt cagctccgcc acttcctggc gcatatcgaa cagaacagaa
    14161 taaagaatct cccgttcgct ctcaaagcct ttactctcac gcgttcccat cagcgcggga
    14221 agacgttgcg tattttgtgc gggaagataa ttctgcaaga tagcagcaga gatctccctg
    14281 ttggtttcaa tgatagatat ttgctcggtg atgttcttca actgacgcac gtttccgggc
    14341 cacgggtaag ccaataactc tttcttcgca tcctccgtca actggatagc aggcatccgg
    14401 tatttctctg caaagtctgc ggaaaactta cggaacaaca aaagtacatc gtcaccacgt
    14461 tcacgcaaag gcggtatttg gataggcacc gtattcaacc ggtaatataa atcttcacgg
    14521 aaacgtcctt ctgcaatcgc ttgtgtcaga ttgacattgg tagctgccac aatacgaaca
    14581 tccgtctttt gcactttgga cgaacctact tttataaact cgccactctc caacacacgg
    14641 agcaaacgcg cctgggtagg catcggcaac tcccctactt catctaggaa aatagtacca
    14701 ccgtcggctt cgccaaagta ccctttccgt tcgccaatcg caccggtaaa cgcacccttc
    14761 tcatgcccga acagttcgga atcaatcgtg ccctccggaa tagcaccaca gttgacagca
    14821 atatactgtc cgtgcttcct ccggctatat tgatgaataa tctgcggaaa actttctttt
    14881 ccgactccac tttctccggt aatcagcaca gacaaatcgg taggagctac ctgaatggca
    14941 acatctatgg cgcgcgacaa tgcttcagta tttccaataa taccgaaacg ttgtttcact
    15001 tgttgtatct ctgctctcgt catcactcgt ttttaatctt cgtctactgt atccagcttc
    15061 agtttatcac tatcgtcacg tttctcgtaa tactgtttac gcaacggatt ggcacgagcc
    15121 actttttccc gctgacgatt acggaacaca tcgatggcaa catagattgc ctgacggaaa
    15181 gaatcttcac aagccaatcc cttgcctgca atatcgtat
//
