LOCUS       gnlProkkaMEGPPFDI_255  15243 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|MEGPPFDI_255.
ACCESSION   gnlProkkaMEGPPFDI_255
VERSION     gnlProkkaMEGPPFDI_255
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2024-11-30 23:24:15
            Original ID  :: gnl|Prokka|MEGPPFDI_255
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 15243
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..15243
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="True"
                     /core_location="[4868:5243]"
                     /cutoff="10000"
                     /detection_rule="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /neighbourhood="10000"
                     /product="RRE-containing"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      4869..5243
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /neighbourhood="10000"
                     /product="RRE-containing"
                     /protocluster_number="1"
     cand_cluster    1..15243
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /kind="single"
                     /product="RRE-containing"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..15243
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="RRE-containing"
                     /region_number="1"
                     /rules="minimum(1, [Bottromycin_Methyltransferase_RRE,
                     Cyanobactin_D_RRE, Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /tool="antismash"
     CDS             2..187
                     /locus_tag="ctg255_1"
                     /transl_table=11
                     /translation="MDIAGKGVACEDSFRQAIYVAIDVFRNRQREKVARANPLRKQYYE
                     KRDDSDKLKLDTVDED"
     CDS             197..1438
                     /gene_functions="regulatory (smcogs) SMCOG1112:sigma-54
                     dependent trancsriptional regulator (Score: 390.2; E-value:
                     2.3e-118)"
                     /gene_kind="regulatory"
                     /locus_tag="ctg255_2"
                     /transl_table=11
                     /translation="MTKAEIQQVKQRFGIIGNTEALSRAIDVAIQVAPTDLSVLITGES
                     GVGKESFPQIIHQYSRRKHGQYIAVNCGAIPEGTIDSELFGHEKGAFTGAIGERKGYFG
                     EADGGTIFLDEVGELPMSTQARLLRVLESGEFMKVGSSKVQKTDVRVVAATNVNLTQAI
                     AEGRFREDLYYRLNTVPIQIPPLRERGDDVLLLFRKFSADFAEKYRMPAIQLTEDAKKE
                     LLAYPWPGNVRQLKNITEQISIIETNREISAAILQNYLPAQNTQRLPALMGTRESKGFE
                     SEREILYSVLFDMRQEVAELKKMVHNLMAERAGQVGQVGQMGTVVTTPVVTAHQPSVPA
                     IIHTMQPTVCKDDDDIQDTEEYVEESPLSLDEVEKEMIRKALERHHGKRKSAAKDLNIS
                     ERTLYRKIKEYELD"
     CDS             1425..1952
                     /locus_tag="ctg255_3"
                     /transl_table=11
                     /translation="MNWIKKIIRPLLLFGLPLVVIACTVSYKFNGSSINYDKVKTISIA
                     DFPIKSEYVYAPLATKFNEDLKDIFIRQTRLQLLKPSQNADLQIDGEITGYNQYNQAVS
                     ADGYSSETKLTITVNVRFVNNTNHAEDFEQQFSAFRTYDSTQLLTAVQDGLIAEMSKEI
                     TDQIFNATVANW"
     CDS             1958..2731
                     /locus_tag="ctg255_4"
                     /transl_table=11
                     /translation="MTSVNFQQWIQHPETLNRDTLYELRNLLARYPYFQSLRLLYLKNL
                     YILHDISFGGELRKAVLYIADRRQLFRLIEGDRYDVQARKKGVPLTEVLKDEPSVDRTL
                     ALIDAFLSTVPEEVTARTSFDYSMDYTSYLLEETPATEQSAEETPKLKGYELIDDFIEK
                     SESDSPLCKKPLREEMPSSPTSSDELTEEETMKEEEEDDSCFTETLAKIYVKQQRYSKA
                     LEIIKKLSLKYPKKNAYFADQIRFLEKLIINANSK"
     CDS             2738..3133
                     /locus_tag="ctg255_5"
                     /transl_table=11
                     /translation="MYLLFVILMVIAALLMCFIVLIQNSKGGGLASGFSSSNAIMGVRK
                     TTDFLEKATWGLAIFMVVMSIATAYVVPRSAVAKDAVLEQAQKEQQTNPYNLPAGTAAP
                     QTEAPATNAPATETPAPATETPAPAAE"
     CDS             3383..4771
                     /gene_functions="transport (smcogs) SMCOG1106:major
                     facilitator transporter (Score: 92.3; E-value: 4.1e-28)"
                     /gene_kind="transport"
                     /locus_tag="ctg255_6"
                     /transl_table=11
                     /translation="MTEHLKQKLNDSAVLRWSVLALVAFTMLCGYFLTDVMSPLKPMLE
                     KELLWDSLDYGFFTSAYGWFNVFLLMLIFGGIILDKMGVRFTGMGACLLMVFGCGLKYY
                     AISTTFPEGAMLFGFKTQVTLAALGYAIFGVGVEIAGITVSKIIVKWFKGKEMALAMGL
                     EMATARIGTTLAMVLTVPLADFFGSTDESGTFHTNIPAPILFCLIMLCVGTIAFFLYTF
                     YDKKLDASLDAEGLEPEEPFRMKDIVYIITNKGFWLIALLCVLFYSAVFPFIKYAADLM
                     VQKYNVDPKLAGTIPGLLPIGAIILTPLFGSLYDRIGKGATLMIIGSVMLIFVHTMFAL
                     PILNIWWFATIIMIILGFAFSLVPSAMWPSVPKIIPEKQLGTAYALIFWVQNWGLMGVP
                     LLIGWVLNTYCKGPVVDGAQTYDYTLPMTIFALFGVLALIVALMLKAENKKKGYGLEEA
                     NIQK"
     CDS             4869..5243
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RRE-containing: PqqD_RRE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF05402"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg255_7"
                     /sec_met_domain="PqqD_RRE (E-value: 3.3e-11, bitscore:
                     34.1, seeds: 9, tool: rule-based-clusters)"
                     /sec_met_domain="PF05402 (E-value: 1.2e-17, bitscore: 55.3,
                     seeds: 461, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAAKEKINLLEVIPCRSEHITAEREGETIVLSFPRFKYPWMQRFL
                     VPKGMSKELHVKLEEHGTAVWELIDGKRNVREIIEKLADHFQNEEGYESRVSAYLSQMQ
                     KDGFIKLVIPVVYRNLLLFI"
     CDS             complement(5236..5520)
                     /locus_tag="ctg255_8"
                     /transl_table=11
                     /translation="MVGEGHAFDMIRRIKEGREASRLRRERANDKLKHLNRANEPYPLP
                     NTTPEEMERIIHDSEKKKEKDSNYFVWGTLIIMGVLIAIAVILWAVFIK"
     CDS             complement(5557..6624)
                     /locus_tag="ctg255_9"
                     /transl_table=11
                     /translation="MKKLIIAAGLLMTTSAYAQTEVLTGVTRGKDYGVVYSLPKTQIEL
                     EIKANKVNYTPGEFSKYADRYLRLTNVSADPEEYWELASVKVKSVGVPNSETTYFVKLK
                     DKTVAPLMELTEDGIVKTINVPYSNSSVGKKAAPAPAVLQKKANPREFLTEEILMASST
                     AKMAELVAKEIYNIRESKNALLRGQADNMPSDGAQLKIMLDNLNAQEEAMTQMFSGTCN
                     KEERTFTVRLTPDKEFNNEVAFRFSKKLGVVANNDLAGTPFYISLKDLKSVKMPQEDGK
                     KKKDLDGIAYNVPGQAMVTLTDGKKKLYEGELPITQFGVIEYLAPVLFNKNSTIKVYFD
                     PNTGGLLKVDREEGK"
     CDS             complement(6697..8208)
                     /locus_tag="ctg255_10"
                     /transl_table=11
                     /translation="MKIFPSSSIKKLDAYTIENEPIASIDLMERAATVLTKAITDRWNT
                     ETPVTIFAGPGNNGGDALAVARMMAEKGYKIEVFLFNTKGELSPDCQTNKELVEMMEEV
                     KFHEISTQFVPPVLTPDHLVIDGLFGSGLNKPLSGGFAAVVKYINSSPAMVVAIDIPSG
                     LMGEENTFNVKANIIRADVTFSLQLPKLAFLFAENTEFVGEWEVLDIQLSEDGIEEMET
                     NYEMLEIEQIRSLIKPRKQFAHKGNFGHALLIAGSKGMAGASVLAARACLRSGVGLLTV
                     HAPMCNNDILQTSIPEAIVETDINETCFAVPTDTDDYQAVGIGPGLGRNEETEAALLEQ
                     LEHCQTPVVVDADALNILANHRHALTHLPKGSILTPHPKELERLTGKCQDSYERLMKAC
                     ELARAAHVHIILKGAYSAIITPEGKCFFNPTGNPGMATGGSGDVLTGVILALLAQGYPT
                     EEAAKIGTYIHGLAGDVAQKKQGMIGMIASDIITCLPTAWRLVSE"
     CDS             complement(8483..8599)
                     /locus_tag="ctg255_11"
                     /transl_table=11
                     /translation="MRNTLKYYENKVAFEPKYGRTYEKYRFEKVFLIRYLFD"
     CDS             9270..9494
                     /locus_tag="ctg255_12"
                     /transl_table=11
                     /translation="MMEKTKIGLNAGKVWRILNEKGELSMFDLCRELSLTFEDVALAIG
                     WLAREDKIFLRKREGMLFASIENVEFTFG"
     CDS             9687..11231
                     /gene_functions="transport (smcogs) SMCOG1202:major
                     facilitator transporter (Score: 46.8; E-value: 2.5e-14)"
                     /gene_kind="transport"
                     /locus_tag="ctg255_13"
                     /transl_table=11
                     /translation="MSALKGHPKGLYLIFATSTAERFSYYGMRAIFILFLTQALLFDKE
                     AAASIYGSYTGLVYLTPLIGGYIADKYWGIRRSVFWGAVMMAVGQFLMFMSASTLDNTN
                     LAHWMMYGGLGFLILGNGCFKPTVSSLVGQLYEPGDRRLDAAYTIFYMGVNVGSFAAPL
                     ICGYLGDTGDPHDFKWGFLAAGIMTLFTVVLFETQKNKYLFSPSGEPIGIIPDAKREKK
                     EDKADHISHPKMDKRTKVRNTLVITILTIALIAFFNYAFEGDWVSIGIFTACIVFPVLI
                     LLDGSLTKIERSRIFVIYIVAFFVIFFWAAYEQAGASLTLFASEQTNRDIFGWEMPASW
                     FQSFNPLFVVVLAYIMPGVWGFLNKRKMEPASPTKQAIGLLLLSLGYLFICFGVKDAVP
                     GVKVSMIWLTGLYFIHTMGEIALSPIGLSMVNKLSPLRFASLMMGIWYLSTATANKFAG
                     MLSGLYPEAGKVKSIFGYQIATMYDFFMVFVVMSGVASLILFLLSKKLQKMMHGVE"
     CDS             11272..11808
                     /locus_tag="ctg255_14"
                     /transl_table=11
                     /translation="MDTIQIKDKLFTVSIKEQEIQKEVIRVANEINRDLAGKNPLFLSV
                     LNGSFMFTADLLKHITIPCEISFVKLASYQGITSTGVIKEVIGLNEDIAGRTIVIVEDI
                     VDTGLTMQRLLETLGTRNPEAIHIASLLVKPEKLKVNLNIEYVAMEIPNDFIVGYGLDY
                     DGFGRNYPDIYTVVD"
     CDS             11868..12437
                     /locus_tag="ctg255_15"
                     /transl_table=11
                     /translation="MLNIVIFGAPGSGKGTQSERIVEKYGINHISTGDVLRAEIKNGTE
                     LGKTAKGYIDQGQLIPDELMIDILASVFDSFKDSKGVIFDGFPRTIAQAEALKKMLAER
                     GQDVSVMVDLDVPEEELMVRLIKRGKDSGRADDNEETIKKRLHVYHSQTAPLIDWYKNE
                     KKYQHINGLGTMEGIFAEICEAVDKL"
     CDS             12527..13690
                     /locus_tag="ctg255_16"
                     /transl_table=11
                     /translation="MAESNFVDYVKIYCRSGKGGRGSTHMRREKYCPNGGPDGGDGGRG
                     GHIILRGNRNYWTLLHLKYDRHAMAGHGESGSKGRSFGKDGADKIIEVPCGTVVYNAET
                     GEYLCDVTEDGQEVILLKGGRGGQGNWHFKTATRQAPRFAQPGEPMQEMTVIMELKLLA
                     DVGLVGFPNAGKSTLLSSISAAKPKIADYPFTTLEPNLGIVSYHGGKSFVMADIPGIIE
                     GASQGKGLGLRFLRHIERNSLLLFMVPADSDDIRKEYEVLLNELRTFNPEMLDKQRVLA
                     VTKSDMLDQELMDEIEPTLPEGIPHVFISSVSGLGISVLKDILWEELNKESNKIEDIVH
                     RPKDVTRLQQELKDMGEDEDIVYEYEEDVDDDDDIDYEYEEEDWEEK"
     CDS             13687..14499
                     /locus_tag="ctg255_17"
                     /transl_table=11
                     /translation="MISLTKHNELKGYKSLEAYPEVAHFVTTRHEGISTGAYGSFNCSP
                     YTNDSCMNVNRNQSWLFQCMNHQIKELFIPEQNHGCASLIINESFFKESLEMRRLLLRG
                     MDALITNVPGYCVCVTTADCVPVLLYDKKQHVVAAVHAGWKGTVKHIVSNVMDHLNKMF
                     GTQGEDVIACIGPSISLESFEVGDEVYDAFEESGFDMSLISMKKKETGKYHIDLWEANR
                     IELLNLGVPAEQIEVAGICTYIHHDEFFSARRLGIDSGRTLSGIMIRK"
     CDS             14550..15215
                     /locus_tag="ctg255_18"
                     /transl_table=11
                     /translation="MFEIKVSKEIKDACPVFAGAAVYAAVKNTAYNEGLWQEIDAFTRQ
                     LTSTTQMEDIKHQPVIFATREAYKRCGKDPGRYRPSAEALRRRLMRGIPLYQIDTLVDL
                     INLVSLRTGHSIGGFDADKIQGTHLELGIGKAGEPFEGIGRDVLNIEGLPVYRDSFGGI
                     GTPTSDHERTKMDLETTHILAIVNGYNGKEGLREAAEMIQTLLRNYTESDGGEIVFFE"
ORIGIN
        1 atacgatatt gcaggcaagg gagtggcttg tgaagattct ttccgccagg caatctatgt
       61 tgccatcgac gtgttccgta atcgtcagcg tgaaaaagtg gctcgtgcca atccgttgcg
      121 taaacagtat tacgagaaac gtgacgatag tgataaactg aagctggata cagtagacga
      181 agattaaaaa cgagtgatga cgaaagcaga gatacaacaa gtgaaacagc gtttcggtat
      241 tattggaaat actgaagcat tgtcgcgcgc catagatgtt gccattcagg tagctcctac
      301 cgatttgtct gtgctgatta ccggagaaag tggagtcgga aaagaaagtt ttccgcagat
      361 tattcatcaa tatagccgga ggaagcacgg acagtatatt gctgtcaact gtggcgctat
      421 tccggaaggt acgattgatt ccgaactgtt cggacatgag aaaggtgcgt ttaccggtgc
      481 gattggcgaa cggaaagggt actttggcga agccgacggc ggtactattt ttcttgatga
      541 agtaggggag ttgccgatgt ctacccaggc acgtttgctc cgtgtactgg agagtggcga
      601 gtttatgaaa gtaggttcgt ccaaagtaca aaaaacggat gtgcgtgtgg tggcggctac
      661 caatgtcaat ctgacacaag cgattgcaga aggacgtttc cgtgaagatt tatattaccg
      721 gttgaatacg gtgcctatcc aaataccgcc tttgcgtgaa cgtggtgacg atgtactttt
      781 gttgttccgt aagttttccg cagactttgc agagaaatac cggatgcctg ctattcagtt
      841 gacggaggat gcgaagaaag agttgttggc ttacccgtgg cccggaaacg tgcgccagtt
      901 gaagaacatc accgagcaaa tatctatcat tgaaaccaac agggagatct ctgctgctat
      961 cttgcagaat tatcttcccg cacaaaatac gcaacgtctt cccgcgctga tgggaacgcg
     1021 tgagagtaaa ggctttgaga gcgaacggga gattctttat tctgttctgt tcgatatgcg
     1081 ccaggaagtg gcggagctga agaagatggt gcacaacctg atggcggaac gtgccggaca
     1141 ggtggggcag gtaggacaaa tgggaacggt ggttactact ccggtagtga cggcgcatca
     1201 accttcggta cctgctatta ttcacaccat gcagcccacg gtttgcaagg atgatgatga
     1261 catacaagac acggaagaat atgtagaaga atctcctttg tcactggacg aagtggagaa
     1321 agaaatgata cgcaaagcac ttgagaggca tcatggaaag cggaagagtg cggccaagga
     1381 cttgaatatt tccgagcgta cactttatag aaaaataaaa gaatatgaat tggattaaga
     1441 aaataatacg ccctttgtta ctgttcggct tgccgttggt agtcattgcg tgcactgttt
     1501 cctataagtt taacggatcg tctatcaatt atgataaggt aaagaccatt tcgatagccg
     1561 acttcccgat caagtcggag tatgtgtatg ctccgttggc aaccaagttc aatgaggacc
     1621 tgaaagatat cttcatccgg cagactcgtc tgcaactgct caagccgagt caaaatgccg
     1681 acttgcagat tgacggagaa atcacagggt acaatcagta caatcaggca gtatctgccg
     1741 acggttattc ttcggagacg aagttgacta tcaccgtcaa tgtacgtttt gtcaacaaca
     1801 ccaatcatgc cgaagacttt gaacaacagt tttctgcgtt ccgtacctac gactctaccc
     1861 agttgctgac tgctgtacag gacggattga ttgctgaaat gtctaaagag atcaccgacc
     1921 aaatttttaa tgcaactgta gcaaactggt aatataaatg acttctgtta actttcaaca
     1981 atggattcag catcccgaga cgctgaatag ggatactttg tacgaactgc gcaatcttct
     2041 tgcgaggtat ccgtattttc agtcacttcg tctgctgtat ctgaagaatc tgtatattct
     2101 ccatgatatt agttttggtg gagaactgcg gaaagcagtt ctttacattg cagacagacg
     2161 gcagttgttc cggttgattg aaggtgaccg ctatgatgtg caggcacgga aaaagggagt
     2221 acctcttacg gaggtactga aagacgaacc gtccgtagac cgcacattag cattgatcga
     2281 cgctttcttg tccacagtac ccgaagaggt gactgcccgc accagcttcg actattcgat
     2341 ggattacacc tcttatcttt tggaggagac tccggccacg gaacagtcgg ccgaagaaac
     2401 gcccaaactc aaaggctacg aactgattga cgactttata gaaaagagcg agagcgactc
     2461 tcccctctgc aagaaacctt taagagaaga aatgccatct tcgccaacct cttcggacga
     2521 acttaccgaa gaagaaacga tgaaggaaga agaggaagat gacagctgtt ttacggaaac
     2581 tttggcaaaa atctatgtta aacagcaacg atattcaaaa gctcttgaaa taattaaaaa
     2641 attaagcttg aaatatccaa aaaaaaatgc ttactttgca gaccaaatca gatttttgga
     2701 gaaattgatt attaacgcta attcaaaata actaaaaatg tacttattat tcgttatctt
     2761 aatggttatt gcagccttgt tgatgtgttt catcgtgctg attcagaact caaaaggagg
     2821 cggacttgct tctggtttct cttcatctaa cgccatcatg ggcgtgcgca agactacaga
     2881 ttttctggaa aaagcaacat ggggcttagc tatcttcatg gtggtaatga gcattgctac
     2941 tgcttatgta gttcctcgct ctgctgttgc taaagacgca gtgttggaac aggcacagaa
     3001 agaacaacag actaacccgt ataacttacc cgcaggtacg gctgcgccgc aaactgaagc
     3061 tcctgctacc aatgcacctg ctacagaaac tccggcaccg gctactgaaa ctcctgctcc
     3121 tgcagcagag taattcactc cgttgtcagg taagactttg gggtaaaacc attaatggga
     3181 aggtgcagac ggatgctgca tttctttgat atttaagtgc ggattacgca gattacacgg
     3241 attttcaatc ttccgcgtgg tcagtgtaat ccgcacttaa ctttttcttg taaaaacaat
     3301 ctctttttga tagaaacaaa cgagatttaa ctacctttgt tggtcgtatg aagattatta
     3361 actactattt ttaaatataa caatgacaga acatttgaaa cagaaattga atgactccgc
     3421 cgtactccga tggagtgttc tagcattagt cgcatttact atgctatgcg gctatttcct
     3481 caccgacgta atgtctcctc taaaacccat gcttgagaaa gaactactat gggacagtct
     3541 ggattatggt ttcttcacaa gcgcttacgg gtggtttaat gtattcctat tgatgctgat
     3601 tttcggtggt atcattttgg ataagatggg agttcgtttc accggaatgg gagcttgctt
     3661 attgatggtg tttggttgtg gattgaaata ctatgcgatt tctactactt ttccggaagg
     3721 tgccatgctc ttcggattca aaacacaggt aaccctggct gcattggggt atgctatctt
     3781 cggtgtaggt gtggaaattg ccggtatcac agtttccaag attatcgtaa aatggttcaa
     3841 gggtaaggaa atggcattag ctatgggact tgaaatggct acggcacgta tcggaacaac
     3901 tctggcaatg gtgcttacgg ttcctttggc cgactttttc ggatctacgg atgagagtgg
     3961 cacattccat accaatattc ctgctccgat tttgttttgt ctgattatgt tgtgcgtggg
     4021 tacgattgct ttcttccttt atactttcta tgataagaag ttggatgctt ctttggatgc
     4081 agaaggattg gagccggaag agccgttccg tatgaaagat attgtgtata tcattaccaa
     4141 taaaggattc tggctgattg cattactatg tgtattgttc tactcggctg tattcccctt
     4201 tatcaagtat gctgccgact tgatggtgca gaagtataat gtagatccga agttggcggg
     4261 aacgattccc ggattgttgc cgattggtgc gattatcctg actccgttgt tcggctcgct
     4321 ttatgaccgt attggtaagg gagccacatt gatgataatc ggatcagtga tgcttatttt
     4381 tgtgcatacg atgttcgctc tgcctatact gaatatatgg tggtttgcta ctattatcat
     4441 gattatattg ggatttgcct tctcgttggt gccttcagct atgtggccgt ctgttccgaa
     4501 gattattccg gaaaaacagt tgggtaccgc atacgcattg attttctggg tacagaactg
     4561 gggattgatg ggtgttcctt tgttgatcgg atgggtgttg aatacttatt gcaaaggtcc
     4621 ggtagtagat ggtgcacaga cttatgacta cacgttgccg atgactattt ttgctctttt
     4681 tggtgtgctt gctctgattg tggctttgat gttgaaggca gagaacaaga agaagggata
     4741 cggtttggaa gaggcgaata tccaaaagta actgggaaat tcaataccta aagtaacaaa
     4801 ggaattttgt atcaaggtgt aaacagaaga gtatcagtat aaatactctg aaataaaaaa
     4861 taagaagtat ggctgccaaa gagaaaatca acctgttaga ggtcattccc tgtcgcagtg
     4921 aacatattac agcagaaagg gaaggggaga caattgtgct ctcctttccc cgttttaaat
     4981 atccgtggat gcaacgcttc cttgtgccga aaggaatgtc gaaagaactt catgtgaaat
     5041 tggaagaaca cggtacggct gtatgggaac tgatagatgg aaaacgcaat gttcgtgaga
     5101 ttatagaaaa actcgcagac cactttcaaa atgaagaggg ctacgagtcg cgtgtatcgg
     5161 cttatctttc tcaaatgcag aaagatggat ttataaaact ggtgatacca gtcgtatata
     5221 ggaacttatt attatttatt tgataaatac agcccaaagt atgacggcaa ttgctatcag
     5281 gacccccatg ataataagcg ttccccaaac aaaataattg ctgtctttct ctttcttttt
     5341 ctccgagtcg tggatgatac gctccatttc ttcgggagtg gtgttaggta gtggataagg
     5401 ttcgtttgca cggtttagat gcttcaactt atcgttagca cgttcacgac gtaggcggga
     5461 agcttcccgt ccctctttta ttcggcgtat catgtcgaat gcatgtcctt caccaaccat
     5521 attctttgtt ttttagaagt tcacttcctc gtttttctat ttcccttctt ctctgtccac
     5581 tttgagcaat cctcccgtat tcggatcaaa ataaactttg atggtagaat tcttgttgaa
     5641 caaaaccgga gccagatatt ctatcacacc gaattgggta ataggaagct caccttcgta
     5701 aagtttcttt ttaccgtcgg tcagtgtaac catagcttgt ccggggacgt tgtaggcgat
     5761 tccatccaaa tctttcttct tcttaccgtc ttcctgtggc atcttgaccg atttcaggtc
     5821 tttcagactg atataaaacg gagttcctgc caaatcattg ttggcaacta cacctaactt
     5881 cttcgagaag cggaaagcaa cttcattgtt gaattccttg tcaggggtaa ggcggacagt
     5941 gaatgttctt tcttctttgt tgcaggtgcc ggagaacatt tgtgtcatgg cttcttcctg
     6001 tgcattcaga ttgtcgagca taatcttaag ctgtgcccca tctgaaggca tattatcagc
     6061 ttgtccgcgc aataaggcat ttttgctttc gcggatatta tagatctctt tagccaccag
     6121 ctcggccatc ttggcggtag agctggccat cagaatctcc tcggtcagga attcacgagg
     6181 attcgctttc ttttggagga ctgcgggggc gggagcagct tttttgccta cactgctatt
     6241 gctgtaagga acattgatcg ttttcacaat gccatcctct gtcagttcca tgagcggtgc
     6301 tactgtctta tccttcaatt ttacgaaata cgtagtttcg ctgttgggca cacctacgga
     6361 tttcactttt acgctagcca gttcccagta ctcttcaggg tcggcggaga cgttggtcag
     6421 tcgcaggtaa cgatcagcat atttgctgaa ttctccggga gtatagttga ctttgttggc
     6481 ttttatttca agttctattt gggttttggg aagactgtaa accactccat agtcttttcc
     6541 tcgggtaacc cccgtcagta cttcggtttg tgcataggcg gacgttgtca taagtagtcc
     6601 tgctgctata atcaactttt tcatattcgg ttctttttaa ctggttttga aaacaaagtt
     6661 aatgaagtta ttgaaaaaag ggtaagttct taacttttat tcgcttacaa gtcgccatgc
     6721 tgtcggcaga caggtgataa tatcgcttgc gatcattccg atcattcctt gcttcttttg
     6781 agcgacatcg cccgccagtc cgtgaatgta agtgccgatt ttagcggctt cctcggtggg
     6841 gtaaccttgg gcaagcagtg ccaggattac tccggtcagt acgtcaccgc tacctccggt
     6901 tgccattccc ggatttccgg ttgggttgaa gaaacattta ccttcggggg tgatgatggc
     6961 ggagtaggct ccttttaaaa taatgtgaac atgggcggca cgggccagtt cgcaggcctt
     7021 catcagacgt tcgtaagagt cctggcattt gccggtcaga cgttccagtt ctttcggatg
     7081 cggggtgagg atggaaccct tcggcaggtg ggtaagtgca tgacggtggt tggcgaggat
     7141 attaagtgcg tcggcatcca ctacaacagg agtctggcag tgttccagtt gttccaacaa
     7201 ggcagcttcc gtttcctcgt ttcgtcccag tcccgggccg atgccgactg cttgatagtc
     7261 gtccgtgtcg gtaggtacgg caaaacaggt ttcgttgatg tcggtttcta cgattgcttc
     7321 gggtatggag gtttgcaaga tgtcgttgtt gcacattggc gcatggacag tcagcaaccc
     7381 tactcccgaa cggaggcagg cgcgggcagc gagaacagag gctcctgcca ttccttttga
     7441 accggcaatc aatagtgcat ggccgaagtt ccccttgtgg gcaaactgtt tgcgtggctt
     7501 gatgagtgaa cggatttgct ctatttccaa catttcgtag ttcgtttcca tctcttcaat
     7561 accgtcttcg cttaattgga tgtccagcac ttcccattct ccgacaaatt ccgtgttctc
     7621 tgcgaaaaga aaggcgagct tcggcagttg cagactgaaa gttacgtcgg cacggataat
     7681 attagctttt acgttgaatg tgttttcttc tcccatcagt ccggaaggaa tgtcgatggc
     7741 tactaccata gcaggggagg aattgatgta tttcactacg gcagcgaatc cgccgctcaa
     7801 cggtttgttc agacctgaac cgaataatcc gtcgattacc agatggtcgg gcgtcaggac
     7861 gggaggtacg aattgggtac tgatttcgtg gaattttact tcttccatca tttctaccaa
     7921 ttctttattg gtctggcagt cgggtgaaag ttctcctttc gtgttgaaga gaaatacctc
     7981 gattttatat cctttttcag ccatcatgcg ggctacggcg agagcgtctc cgccattatt
     8041 ccccggtccg gcaaagatag tgaccggcgt ttctgtattc catctgtctg tgatggcttt
     8101 tgttaatacg gttgctgcac gttccatcag atcgattgat gcaataggtt cgttctcaat
     8161 ggtataagcg tccaatttct tgatactgct gcttggaaat attttcattg cgatgttctt
     8221 ttagttttcg gattacaaat gtacatgatt cttctgactt ttcccgtttg ttgtgggaag
     8281 aaaaccataa ttgcaacttt taattcatca ttagttctat ctttgggtca gagaaatatc
     8341 tgcttttgaa ctattaagtg ttagaataac tccgccaaaa aataattcaa tgcagcacca
     8401 ttatgaactt acttttattt ctcctgaaaa agatttcttc atttcatttc tcatattctc
     8461 attgtttttc gataaacgaa agctaatcaa atagatatct tatgagaaac actttttcga
     8521 aacggtattt ctcataagtt ctcccatatt ttggctcaaa agccacctta ttctcatagt
     8581 atttcagggt atttctcata gtcaaaagcc atttgttctt ccttttttct ttcagcctgc
     8641 cttattttta tcaggaaatg aagctactat ttagataaaa tagtggcttt ttgcttgaag
     8701 atgctcattg gtctcgattg tcccatatat tgtgggaaag ttttccttca atatacggga
     8761 atactttcct acaaaatacg ggaatacttt cccaagcctt agggaatctt ttcccacaat
     8821 atgtggaact aagacactgt gtatggaagc aagcaaaagg aatacatagt tttatttatt
     8881 caatgtcagc ttccggcaca ctacactatg agaaatgaag caaaatccgg gttattttgc
     8941 gaagaaacta tgagaaatgc ctgtttttaa atcatttctc atagtctatc ttattagttt
     9001 actgccactt gtttcttatt tatgagaata tgagaaatga aaaatctttt tctgtagagg
     9061 cgcggatgaa aattgtgttt agtttatcgc cataccttct taaacaaatt tttaatgcgg
     9121 ttccccttat taagcctttg attatttgcc gtttccgata aaaatgttat ctttggagat
     9181 agataatgtg catcacatca ttttccagtg ctcacaatga aaatgaatta aaatctaaat
     9241 aacggattgt ttaatcttct aaagtttgca tgatggaaaa gacaaaaatt ggcttgaatg
     9301 ccgggaaagt atggcgcatc ttaaatgaaa aaggtgaact ttcaatgttc gatttgtgcc
     9361 gtgaattaag tttgacgttt gaagacgtag ctctcgctat tggttggctg gcccgagaag
     9421 acaaaatctt tttgaggaaa agagaaggaa tgctttttgc cagtatcgaa aatgtcgaat
     9481 ttacttttgg ctaaggtggt agctaaccta catttaagat ggatctccac tttattattt
     9541 acactgctaa aaaagtaatg aagtggatca gtaggatttt tatgctcgtt tttactattc
     9601 cccctattat tctgtttgat aagagaagca tctaatctac tttttctgta cctttgcacc
     9661 ccataaacta ctaaacacat aaattcatga gtgcattgaa agggcatccg aaaggccttt
     9721 atctgatttt cgcgacaagc acggcagaac gtttcagtta ctacggtatg cgtgcgatct
     9781 ttattctttt cctgacgcag gcattattgt ttgacaaaga agcggcagca tccatctacg
     9841 gcagctatac cggactagtt tatttaaccc cgttgattgg cggatacatt gccgataaat
     9901 attggggaat ccgtcgttcc gtgttttggg gagcggtaat gatggcagtc ggacaattcc
     9961 tgatgtttat gagtgcctcc actttagata atacgaacct tgcccactgg atgatgtatg
    10021 gtggactcgg cttcctgatt ctaggcaatg gttgcttcaa acccactgtc tcttctctgg
    10081 taggtcagct ctacgaaccc ggagacaggc ggttggatgc tgcatacacc attttttata
    10141 tgggagtgaa tgtaggctct tttgctgctc ctttgatttg tggttatctg ggtgataccg
    10201 gtgatccgca tgactttaaa tggggatttc ttgcagccgg aatcatgaca ctgttcaccg
    10261 ttgttctttt cgagactcaa aagaataaat atcttttttc tccttccgga gaaccgattg
    10321 gtattatccc cgatgctaaa cgtgaaaaga aagaagacaa ggccgaccat atctcacacc
    10381 cgaagatgga caaacgtacc aaagtacgta acacccttgt aatcacaatt cttaccattg
    10441 ctttaatagc cttctttaac tatgcatttg aaggcgattg ggtgagtatc ggcattttta
    10501 ccgcctgcat tgttttccct gttctgatcc tgttagacgg ttcattgaca aaaatagaac
    10561 gcagccgtat tttcgttatc tatatagtag ccttctttgt catcttcttc tgggcagcct
    10621 acgaacaggc gggagcttct ttaactctct tcgcatccga acagacgaat cgtgacattt
    10681 tcggttggga aatgccggct tcatggtttc aatccttcaa tccactgttt gtagttgtcc
    10741 tggcatatat catgccgggt gtatggggtt tcctgaacaa gcgaaagatg gaacctgctt
    10801 ctcctaccaa acaagcgatt ggtctgttac tcctttcttt aggttatctt ttcatctgtt
    10861 tcggagtgaa agatgcagtt cccggagtga aagtgagcat gatttggctg acaggacttt
    10921 actttattca taccatgggt gaaatagctt tgtcgcctat cggactttca atggtaaata
    10981 aattgagtcc gctgcgtttc gcctccctga tgatgggaat ctggtatctg tctactgcca
    11041 cagctaataa atttgcggga atgttgagcg gactctatcc ggaagccgga aaagtgaagt
    11101 caatctttgg ttatcagatt gctaccatgt atgatttctt tatggtattc gtcgtgatgt
    11161 ccggtgttgc ttcgttgatt ctgttccttc tctcgaagaa attacagaag atgatgcacg
    11221 gggtagaata aaaaatcgta tttttgcaag gttattttta aattaccggt tatggatacc
    11281 attcagataa aagacaaatt gtttaccgtt tccattaagg aacaagaaat tcagaaagaa
    11341 gtgattcgcg tagcgaacga aattaaccgc gatttggcag gtaagaatcc gcttttcctt
    11401 agtgtgttga acggttcgtt catgtttacc gctgatttac tgaagcacat caccatccct
    11461 tgtgaaatct catttgtgaa gttggcgtct tatcagggca tcacttccac cggagtgatt
    11521 aaagaggtaa tcggcctgaa tgaagacatt gccggacgta ccattgtaat cgtagaagat
    11581 attgtagaca caggactgac gatgcagcga ctgctcgaaa cattaggtac acgcaatccc
    11641 gaagctatcc atatcgcttc tctgttggtg aaacctgaaa agctcaaggt aaacctcaac
    11701 attgaatatg tagcgatgga aattccgaac gactttatcg taggttacgg gttggattat
    11761 gatggtttcg gacgtaatta tcccgatatt tatacagtag tagattaata ttaaataggt
    11821 accagtttaa atggtaaata gtaaatcgtt aaattgtaaa taacaaaatg ttgaacatcg
    11881 taattttcgg tgctccgggt tcaggaaaag gaacacagag cgaacgtatc gtagaaaagt
    11941 atggaatcaa tcacatctcg acaggagatg tattgcgtgc tgaaatcaag aatggcacag
    12001 aactgggtaa aacagctaaa ggttacatcg accaaggtca attgattcct gatgaattaa
    12061 tgattgatat tctggcaagc gtattcgaca gcttcaaaga tagcaaaggg gtaattttcg
    12121 acggtttccc aagaacaatt gcacaggcag aagcattaaa gaaaatgttg gcagaaagag
    12181 gacaggacgt ttctgtaatg gttgatctgg atgttccgga agaagaactg atggtacgtc
    12241 ttattaaacg tggcaaggat tccggtcgtg ctgatgataa cgaagagaca atcaaaaaac
    12301 gtctgcatgt atatcattca cagactgctc cactgatcga ctggtacaag aacgaaaaga
    12361 aataccaaca catcaacggc ttgggtacta tggaaggtat cttcgctgaa atctgcgaag
    12421 cagtagataa attgtaataa tacaatatta taaataaata agtcagtagc cggagtgttc
    12481 taattaactg ctctaactac tgactacttt aactcttaaa aaaaatatgg ctgaatcgaa
    12541 ttttgttgat tacgtaaaga tatactgtcg ctcgggtaag ggcggaagag gctctacgca
    12601 catgaggcgc gagaaatatt gtcctaacgg aggtcctgac gggggcgatg gtggaagagg
    12661 aggtcatatc atcttgcgcg gtaaccgtaa ttactggaca ttgctgcact tgaagtatga
    12721 ccgtcatgca atggccggtc atggtgaatc ggggagcaaa ggacgtagct tcggaaaaga
    12781 cggtgcggat aaaataatag aagtgccctg cggaacggta gtttataatg ccgagacagg
    12841 ggagtatctt tgtgacgtaa cagaagacgg acaggaagtg attttgctca aaggcggtcg
    12901 cggcggtcag ggtaactggc atttcaagac ggccacccgt caggctccgc gttttgcgca
    12961 gccgggagag ccgatgcagg aaatgaccgt tatcatggag ctgaaactgc ttgccgatgt
    13021 tggtctggta ggtttcccga atgcgggaaa gtcaactttg ctttcttcca tttcggctgc
    13081 caaaccgaaa attgccgatt acccgtttac tacgctcgaa cccaacttgg gcatcgtttc
    13141 ctatcacggt ggaaaatcct ttgtgatggc ggacataccg ggtattatcg aaggagccag
    13201 tcagggaaaa ggtttgggac tgcgtttctt gcgtcatatc gagcgtaatt cattactgct
    13261 gtttatggtt ccggcagaca gcgacgacat tcgtaaagaa tacgaagttt tgctgaacga
    13321 actgcgtacc ttcaatcctg aaatgttgga caagcaacgt gtgttggctg tcaccaaaag
    13381 tgatatgctc gatcaggagt tgatggacga gattgaacct acattgccgg aaggcattcc
    13441 acatgtattc atatcttctg tttccggttt gggcatctcg gtgttgaaag acatcctttg
    13501 ggaagaactg aacaaggaaa gcaataagat agaggacatc gttcaccgtc cgaaagacgt
    13561 gacccgtctg caacaggaac tcaaagacat gggcgaagat gaagacatcg tttatgaata
    13621 tgaggaagat gtcgacgatg acgatgatat cgattatgaa tacgaagaag aagattggga
    13681 agaaaaatga tttcacttac aaaacataac gagttgaagg gatataagtc actggaggca
    13741 tatcccgaag tagctcattt tgtaactacg cgtcacgaag gtataagcac cggagcttac
    13801 ggctctttca actgttcgcc ttataccaac gactcatgta tgaatgtcaa tcgcaatcag
    13861 agctggttgt ttcagtgcat gaatcatcag ataaaggaat tatttattcc tgaacagaat
    13921 catggctgtg ccagtctgat tatcaatgaa tcatttttta aagaatcatt ggaaatgaga
    13981 cggctacttc tgcgaggaat ggatgccttg ataactaatg tgccgggata ttgcgtttgt
    14041 gtcacgacgg cggattgtgt tcctgtattg ctgtacgaca aaaaacaaca cgttgtggct
    14101 gccgttcatg ccggatggaa aggaacagtg aagcatattg tcagtaatgt gatggaccac
    14161 ttgaataaga tgttcgggac gcaaggcgaa gatgtgatag cttgcatcgg gccgagcatt
    14221 tcgctcgaat catttgaagt aggtgatgag gtgtatgatg cttttgaaga aagcggcttc
    14281 gatatgtctc ttatttctat gaagaagaag gagacgggca aatatcatat tgatttgtgg
    14341 gaagccaacc ggattgaatt actgaatctc ggagtgcctg cagaacagat agaagtggcc
    14401 ggaatctgta cctatattca tcatgatgaa ttcttctctg cacgtagact gggaatagat
    14461 tccggtcgta cattgtcggg aataatgatt agaaagtaat aattagcgtc cgtaatcgca
    14521 ggacgctgat gattggttta tgataagtta tgtttgaaat aaaagtatct aaagaaataa
    14581 aagacgcatg cccggttttt gccggagccg ccgtgtatgc tgcggtgaag aatactgctt
    14641 acaacgaagg gctttggcag gaaatcgacg cttttactag gcaactgact tccacaacac
    14701 agatggaaga catcaaacat caacccgtta tctttgctac ccgtgaggct tataaacgtt
    14761 gtggcaaaga ccccggacgt tatcgtccgt cagccgaagc tctacgccgc cgcctgatgc
    14821 gtggaattcc tttatatcag attgatacgt tggtagacct tattaattta gtgtctcttc
    14881 gcacaggaca ttcgatcggt ggttttgacg cggacaaaat acaaggtacg catcttgaac
    14941 tcggtatcgg caaagcagga gaaccgtttg aaggtatcgg acgcgatgta ttgaatatcg
    15001 aaggattacc tgtatatcgt gattctttcg gcggaatcgg aaccccgaca agcgaccatg
    15061 aacgtacgaa gatggacctc gaaactactc atatcctagc catagtcaac ggttataacg
    15121 gaaaagaagg tttgcgagaa gctgctgaaa tgatacagac cttattaaga aactatacag
    15181 aatcggatgg aggcgaaatc gtattcttcg aataattaga atgagtgctc taagaaaaaa
    15241 gac
//
