LOCUS       gnlProkkaEPPGJGLP_27   12668 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|EPPGJGLP_27.
ACCESSION   gnlProkkaEPPGJGLP_27
VERSION     gnlProkkaEPPGJGLP_27
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2024-12-01 00:29:03
            Original ID  :: gnl|Prokka|EPPGJGLP_27
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 12668
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..12668
                     /aStool="rule-based-clusters"
                     /category="PKS"
                     /contig_edge="True"
                     /core_location="[1:2840]"
                     /cutoff="20000"
                     /detection_rule="(APE_KS1 or APE_KS2)"
                     /neighbourhood="20000"
                     /product="arylpolyene"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      2..2840
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(APE_KS1 or APE_KS2)"
                     /neighbourhood="20000"
                     /product="arylpolyene"
                     /protocluster_number="1"
     cand_cluster    1..12668
                     /SMILES=""
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(APE_KS1 or APE_KS2)"
                     /kind="single"
                     /product="arylpolyene"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..12668
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="arylpolyene"
                     /region_number="1"
                     /rules="(APE_KS1 or APE_KS2)"
                     /tool="antismash"
     CDS             2..1255
                     /NRPS_PKS="Domain: PKS_KS(Iterative-KS) (26-210). E-value:
                     9.5e-23. Score: 72.6. Matches aSDomain:
                     nrpspksdomains_ctg27_1_PKS_KS.1"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     arylpolyene: APE_KS2"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1022:Beta-ketoacyl synthase (Score: 141; E-value:
                     9.3e-43)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg27_1"
                     /sec_met_domain="APE_KS2 (E-value: 4.1e-79, bitscore:
                     255.9, seeds: 16, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKRVIVAGGDILSHFITSGFLSFRSVSAHRCRPYDIQRDGLSLGE
                     ACGAVLLETQGNANHIILSGGAISNDANHISGPSRTGDGLALAINQAMEEAGALPEDIS
                     FINAHGTATVYNDEMESKAIHLAGLSAVPVNSLKPYFGHTLGASGIIETILCIEQLKEG
                     IYYGTLGYETLGVPMPIIVYSTHQPMPMKCCIKTASGFGGCNAALVLSLPDAHLKQKTD
                     SLASCKAAVESANTVTIKPGVVENQGTAIFNSSETDFAPFIREAYKHLGENNMKFYKMD
                     NLCKLGYVAAGYLLKDTNYRPEEIGIILANASASLDTDCRHQAIINKEGDKAASPAVFV
                     YTLPNVVLGEICIRHKIQGENTFFVCQQSDTASLEDYARIVMAKGKLRTCIIGWCELLD
                     GHYQAEFKQLNNISTIYE"
     aSDomain        80..631
                     /aSDomain="PKS_KS"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg27_1_PKS_KS.1"
                     /domain_subtypes="Iterative-KS"
                     /evalue="9.50E-23"
                     /label="ctg27_1_PKS_KS.1"
                     /locus_tag="ctg27_1"
                     /protein_end="210"
                     /protein_start="26"
                     /score="72.6"
                     /tool="antismash"
                     /translation="SAHRCRPYDIQRDGLSLGEACGAVLLETQGNANHIILSGGAISND
                     ANHISGPSRTGDGLALAINQAMEEAGALPEDISFINAHGTATVYNDEMESKAIHLAGLS
                     AVPVNSLKPYFGHTLGASGIIETILCIEQLKEGIYYGTLGYETLGVPMPIIVYSTHQPM
                     PMKCCIKTASGFGGCNAALVL"
     CDS             1248..1529
                     /NRPS_PKS="Domain: PP-binding (22-68). E-value: 5.7e-11.
                     Score: 34.7. Matches aSDomain:
                     nrpspksdomains_ctg27_2_PP-binding.1"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PP-binding"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg27_2"
                     /sec_met_domain="PP-binding (E-value: 1.1e-11, bitscore:
                     34.7, seeds: 164, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNNLDQTKRELMDEVKGKLIEELNLEEITPEDIDDEAPLFGDEGL
                     GLDSIDALEIILILEREYGIKIENPSEGKQIFYSVCTLTDYIIANRKA"
     aSDomain        1314..1451
                     /aSDomain="PP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg27_2_PP-binding.1"
                     /evalue="5.70E-11"
                     /label="ctg27_2_PP-binding.1"
                     /locus_tag="ctg27_2"
                     /protein_end="68"
                     /protein_start="22"
                     /score="34.7"
                     /tool="antismash"
                     /translation="LNLEEITPEDIDDEAPLFGDEGLGLDSIDALEIILILEREYGIKI
                     E"
     CDS             1533..2840
                     /NRPS_PKS="Domain: PKS_KS(Iterative-KS) (152-423). E-value:
                     1.2e-38. Score: 125.0. Matches aSDomain:
                     nrpspksdomains_ctg27_3_PKS_KS.1"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     arylpolyene: APE_KS2"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1022:Beta-ketoacyl synthase (Score: 253.5; E-value:
                     6.3e-77)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg27_3"
                     /sec_met_domain="APE_KS2 (E-value: 2.7e-113, bitscore:
                     368.4, seeds: 16, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKIYVTGLGVVSGIGIGVSENIEALQQGKHGIGKVTLFPTALDVP
                     VSEVKRSNEELKQLLSLPPQRTVSRTALLGMIAAKEAMEDAGLNLRISSNQPKNQLPNQ
                     SVTSQKDQQPLRIGFISATSVGGMDLSERFYESFKKNPKQGRLREVISHDCGASTELIA
                     SYLGINDFITTISTACSSAANAIMLGARLIKHGQLNAVIVGGTDALCRFTLNGFNSLMI
                     LDKIHCRPFDRSRSGLNLGEGAGYLVLQSESSLQRVPYCELSGYANTNEAYHQTGSSPE
                     GDGAFLSMSEAIASSGISPEDIDYINVHGTGTPGNDASEGMALRRIFGEHVPPFSSVKA
                     FIGHTLGASEGIEAVYSVLSIDKGMIYPNLNFTEPMPETELLSETGVKSETGLIPETSF
                     QEGVPIRHVLSNSFGFGGNDSSLLFSATNFPKRTNL"
     aSDomain        1989..2801
                     /aSDomain="PKS_KS"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg27_3_PKS_KS.1"
                     /domain_subtypes="Iterative-KS"
                     /evalue="1.20E-38"
                     /label="ctg27_3_PKS_KS.1"
                     /locus_tag="ctg27_3"
                     /protein_end="423"
                     /protein_start="152"
                     /score="125.0"
                     /tool="antismash"
                     /translation="HDCGASTELIASYLGINDFITTISTACSSAANAIMLGARLIKHGQ
                     LNAVIVGGTDALCRFTLNGFNSLMILDKIHCRPFDRSRSGLNLGEGAGYLVLQSESSLQ
                     RVPYCELSGYANTNEAYHQTGSSPEGDGAFLSMSEAIASSGISPEDIDYINVHGTGTPG
                     NDASEGMALRRIFGEHVPPFSSVKAFIGHTLGASEGIEAVYSVLSIDKGMIYPNLNFTE
                     PMPETELLSETGVKSETGLIPETSFQEGVPIRHVLSNSFGFGGNDSSLL"
     CDS             2853..3998
                     /locus_tag="ctg27_4"
                     /transl_table=11
                     /translation="MQPVYIQRIASIHPQGNHSQENNPKVNDSLDVAANRPFLQACEPD
                     YKDIIANATLRRRMSRIVKMGVACGLECMGELSPEKIGGIITATGLGCLVDTEKFLNNL
                     LDNEERMLNPTPFIQSTFNTIGAQIALIHQIHAYNMTYVHRGLSFESALLDAMMKIEEG
                     SENILVGAMDEMTETSYIIQQRLGLLKGIEAGEGAQFFLLSREAGEHPLAEIRGLETFT
                     GQHTTEEISSRIIRFLQRNGLECQGIQWLVTGKNKKQSLQGDYHEQITGYKKSTINEGK
                     STNQRSIINGESIINEKDIIIKEIMMNESNSIYEELETNLFPESIHLSFKDECGEYPTA
                     SSYAVWKAVKTSINCTTPTNILIYNHHHSINHSLILIRKSV"
     CDS             3995..4675
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1235:polysaccharide deacetylase (Score: 125.9;
                     E-value: 3.4e-38)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg27_5"
                     /transl_table=11
                     /translation="MMIVCLLLCLFLILSFLVYASYSIQSGIYLRSFCKKRTTEKVVAL
                     TFDDGPDPIQTPKVLKVLKEYQATACFFCIGHKIKGNEALLKSMVTEGHLIGNHSYSHS
                     GLFPLYGLSKMKKDLQTCQCELERVTSQPVTLFRPPFGVTNPTIAKAVRQLGYTSIGWS
                     IRTLDTQQSAPDKILARIRKRLEPGAIILLHDRMPGSDQLVKQILDLLKEQGYTVVRPD
                     KLLA"
     CDS             4687..5322
                     /locus_tag="ctg27_6"
                     /transl_table=11
                     /translation="MRTLLLYLSLFFLSIATVHAQSMKKMVQKTEFENRLAKEAQTVKS
                     IESDFTQVKYLDVFDEKVTSKGKFYYQKSNKICMEYFRPMDYLIVINGSKLKIVSDGKK
                     SIMNLSSNKMMAQMQDMLTACMIGDLSKMSSNYQLEYFEDARYYLVKIKPTNKAVQAYI
                     AGIEIYLDKKDMSVHKLRLSETATNYTEYEFYNKKFNSLKNETKFAIR"
     CDS             5297..5857
                     /locus_tag="ctg27_7"
                     /transl_table=11
                     /translation="MRRSLRFVSLTVLLFLGIQVQTSCSPRISGEGSTVPPVIELTQGE
                     ESQKYNIQLDFMKHHMSGMLIVRRMPDNEIRIVASTYFGLSLFDFSLHDDQFNVNSCIE
                     PMKKEKVLKLLEMDFRRLFLNGKDVRVKATKDNATQKRTSGKGFGKSVVYITGDTPGEP
                     AQIKIKHPWIRLTIRLDKLSKEI"
     CDS             5861..6340
                     /locus_tag="ctg27_8"
                     /transl_table=11
                     /translation="MLLDNFYTILSSESSDSTTWTIQIELNPDHTVYQGHFPEHPVVPG
                     VCLLQLIKECAENIRQQKLQIVQVSSCKFLSAINPIETPRIAIVLILKETEEGKFQLQA
                     EGTIKGNTVNKSIVKEDIAKEEIVKENTGKESIIKEENIKDECFIKLKAALTPKA"
     CDS             6337..7527
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Glycos_transf_2"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1123:polyprenol-monophosphomannose synthase ppm1
                     (Score: 83.5; E-value: 3e-25)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg27_9"
                     /sec_met_domain="Glycos_transf_2 (E-value: 6.8e-30,
                     bitscore: 93.7, seeds: 256, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKEQISTAYWHEKLKQLGIIVIIPSYNNGKTLAEVIASVRLYAPE
                     ILVVNDGSTDETPEILNQEANLHIITHPVNQGKGVALKHGLSFAKKQGFRYAITIDSDG
                     QHFASDIPVLIEAIEKEPDTLLVGSRNLTSDNMPGKNTFANKFSNFWFTLETGIKLQDT
                     QSGYRLYPIQRMNVDKWYYTAKYEFELEALVFAAWGGNPVKNIPVHVYYPPQEERVSHF
                     RPFRDFTRISILNTVLVLVTFLWIVPRNFFRKLTWKNCKQFFSNHITHSPESNLRITAA
                     IMLGVFMGIVPAWGYQMLITLFLAHLFRLNKVIAIVAANISIPPMIPFLLYGSYVTGCK
                     VLGEPVNLHLNELSFENVKSVIEQYLIGSVIFAVVCSILAGTIAFILLTACRKKKI"
     CDS             7524..11390
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1035:MMPL domain-containing transport protein (Score:
                     45.7; E-value: 4.5e-14)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg27_10"
                     /transl_table=11
                     /translation="MTQFFIGLYDYFERHKILFYLSLISCVLLMGFFALQVRFEENITQ
                     FFPDTKDSQNTIKVFDNLKIKDKIIIMLSSADTCHQVEPDSLIEAAGQLQQTLTEKAGG
                     TLIKGIFAQVDQSLIGGATDFVYEHLPLFLTDTDYQRFDSLLTEKGIQAIMQKNYTNLL
                     SPAGIALRSYILRDPLGLGSEALKHLQDFQLEANYEIYDEHIFSKDGSTLLMFITPVFS
                     TGSTGKNDELIKILEEELQHVQGESPTIRVEYFGGPSVGVYNARQIKKDTILTSSLALL
                     IIIVFISLVFKRKRSIPLIITPVLFGGLFALFLIFFIKGSISAIAVGAGSAVMGIALSY
                     SIHMLAHQNHVSTVQQLIKEIAYPLTVGSFTTIGAFMGLIFTSSDLLRDFGLFASLALV
                     GTTLFCLIYLPHFLKGQADVKQGCILRIIEKINAYSYEKNKWLVGGILLITVICLFTSQ
                     KVGFNNDMMSLNYEPQHLKQSEEKLMQLFDSDEKTVLFVSVGKDMNQATETYAMTNQKL
                     LALKDQGLIKDYASASQFLISPQEQQLRLKKWKDYWTDEKQQQIREQLETAAAEYRFRP
                     GSFDPFYQWLNQPFGEYHYTAQEDDLSGKLLNEWQTSADSITMLISQIRISDQNKETVY
                     QHFSKDQDVVIFDRSYFANKWVSAINDDFYLILYISSFLIFFALWFSYGRIELTLMSFL
                     PMLVSWVIILGLMGILGIEFNIINIILSTFIFGIGDDFSIFIMDGLQNKYRTGQKVLNS
                     HKTAIFFSAFTTVVGMGALVFAKHPALQSISLISILGMIAVVLVAYTIQPLIFRFFIAG
                     PASKGLPPYTLIGLIRTVLLFLLFFIGCIFLRVLIAVLYLVPVRKSSKQRLVCRLIQIT
                     CKGILLLATAVKKEHINKANERFQHPAIIIANHQSFIDILVLLSLSSKILMVTNHWVWH
                     SPFFGAIIRYVDFYYIGEGYEQYMERMRKKVKEGYSIAIFPEGTRTYNGKMKRFHKGAF
                     YLAETLQLDILPILLYGNNKIIAKAQPFNIRKGIIYTEILPRIPGDDLSFGTTYQERTK
                     RISAYMKEGYARICREKNTTDNPAFYEALIQNYIYKGPVVEWYIRIKVKMERNYRLFNR
                     LIPVQGQITDIGCGYGPLCYMLSLLSEDREILGIDYDEDKIALAQHGWLRNEHLQFRHG
                     NALEYPLPESDVFILNDMLHYMSYEHQRTLLLKCADRLRSQGMIIIRDGNSANTSKHRL
                     TRFTELLSTRIFNFNRTAGELHFTTETQLREIAVTCGMNVEIIPNDKYTSNTIYIFRKP
                     NEHE"
     CDS             11383..12666
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) DAO"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1222:dehydrogenase (Score: 147; E-value: 1.6e-44)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg27_11"
                     /sec_met_domain="DAO (E-value: 3.5e-10, bitscore: 29.4,
                     seeds: 521, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSKYDIIIIGSGLGGLECGAILSKEGFNVCVVEKNTQFGGCFQTY
                     RRKGHLFDTGIHYVGSLDEGQVMNQYFRYFGIMDKLKLKRLDDEAFDTIYYKGKTYDYA
                     MGYPQFIETICRSFPHEKENLKRYAEQLQTVGNLISVDHLKQGTLALEGMKYFCTSAAG
                     LIADITPDPTLQNVLAGSALLYGGLKDVSTFYEHAMINHSYIEGAYRFVDGSMQVSLEL
                     INVIRANGGTVLNNSEATRIIVENEKVQGVIINGEERLESDYVISNMHPQRTLEILDKN
                     RSIKNAYISRIRSLENTYGIFTLYLVMKKKSTPYQNRNLYLHGDHKVWYDKQLYPGRTT
                     NCMISMQASSEDSQYASVISILTPMYMDELSAWKDTTPEHRGESYRSFKKEKTEQLLRF
                     IRSHGIDFSDNIEEIHTTTPLSYRDYTGT"
ORIGIN
        1 ttacaaacgg gtgattgtcg ccggcgggga tattctttct cattttatta ccagcggttt
       61 cttgtctttc cggtcagtca gcgcacaccg atgccggcca tacgatatac aacgggacgg
      121 attaagtcta ggcgaagcct gtggagctgt gcttttagaa actcaaggaa acgcaaatca
      181 tattattcta tccggaggag cgatcagcaa tgatgccaac catatatccg gtccttcccg
      241 gacaggagac ggactggcgc tggctatcaa tcaggcaatg gaagaagccg gagcacttcc
      301 tgaagatatc agctttatca atgcacacgg aacagctacg gtttataatg acgaaatgga
      361 atccaaagcc atacatttgg caggattgtc tgcagttccg gtaaatagtc ttaagcctta
      421 tttcgggcat acattaggag cttcaggcat tattgaaacc atactttgca tagagcaact
      481 aaaagaagga atatactacg gaactttagg atatgagaca ctgggtgttc ccatgcctat
      541 catcgtttat agcactcatc agccgatgcc aatgaaatgc tgtatcaaaa ccgcttccgg
      601 tttcggaggc tgtaatgctg cactggtatt atctctccca gatgctcatt tgaaacagaa
      661 aactgattct ttggcatcct gtaaagctgc cgtagaatca gccaatacag tcacgatcaa
      721 accgggagtg gtagaaaacc aaggaacagc tatattcaat tcttcggaga ctgactttgc
      781 gccgtttatc cgggaagcat acaagcatct gggagaaaac aatatgaagt tctacaagat
      841 ggataatctt tgtaagcttg gatatgtagc tgccggatat ttattgaaag ataccaacta
      901 ccgtccagaa gagattggaa tcattctagc caatgcttcc gcctctttgg atacggactg
      961 cagacatcaa gctatcatca ataaagaagg agacaaagcc gccagtcctg ccgtatttgt
     1021 ctacactctc cccaatgtag tattgggaga aatctgtata cgacacaaaa ttcagggaga
     1081 aaatacattc tttgtctgtc agcaatccga cactgcttcc ttagaggatt acgcaagaat
     1141 tgtgatggcg aaaggtaagt tacgcacatg catcataggc tggtgcgaac tactggacgg
     1201 acattatcaa gcagaattta aacaacttaa taatatatca acgatttatg aataatttag
     1261 atcaaaccaa aagagaactg atggacgaag tgaaaggtaa actaatcgaa gagttgaacc
     1321 ttgaagaaat cactccggaa gatattgacg atgaagcccc tctgtttggc gacgaaggtc
     1381 ttggccttga ctccattgac gcactcgaaa tcatcctgat tttggaacgt gaatatggca
     1441 ttaaaataga gaatcctagt gaaggaaaac aaatcttcta ctcggtatgt acactgactg
     1501 actacatcat tgctaatcgg aaagcttaac ttatgaagat ttacgtcacc ggattgggag
     1561 ttgtttcggg catcggcatc ggagtttccg aaaatataga ggcactacaa caaggaaagc
     1621 atggtatcgg aaaggtaact cttttcccga ctgctctcga tgtacccgta tctgaagtga
     1681 aacgtagcaa tgaagaactt aaacaactat tatctttacc tccgcagcgt acagtatcac
     1741 gcacagcatt gctaggcatg atagccgcca aagaagcgat ggaagatgca ggactaaact
     1801 tgcgtatatc atccaatcag ccaaaaaatc aattaccaaa tcagtcagta acctcgcaaa
     1861 aagaccagca accgttacgt attggtttta tttccgccac ctctgtcggc ggtatggatt
     1921 taagcgagcg tttctatgaa tctttcaaga aaaacccgaa acagggacga ttgcgggaag
     1981 tgatttcaca cgactgcgga gccagtaccg aattaatagc ttcgtattta ggtatcaatg
     2041 attttataac caccatcagt acagcctgtt catcggcagc caatgctatt atgttgggag
     2101 cgagactgat taaacatgga caactgaatg ctgttatcgt cggaggtacg gatgcacttt
     2161 gccggtttac gctcaatggg ttcaactctc tcatgatttt ggacaaaata cattgtcgtc
     2221 cttttgaccg ttcacgttcc ggattaaatt tgggagaagg cgcgggttat ttagtgcttc
     2281 aatcagaaag ttcactccaa agagttcctt actgtgaact aagcggttat gctaatacaa
     2341 atgaagctta tcatcaaaca ggaagttctc ccgaaggaga tggcgccttt ctatcaatga
     2401 gtgaagccat cgcttccagt ggcatttctc ctgaagatat tgattatatc aacgtacatg
     2461 ggacaggtac tcccggtaat gacgcatcgg aaggaatggc actacgaaga atcttcggag
     2521 aacatgttcc accgtttagt tcggtaaaag cttttatcgg acacacttta ggagcttccg
     2581 aaggaattga agctgtttat tccgttcttt ccatagataa aggcatgatt tatccgaatc
     2641 tgaatttcac ggagcctatg ccggaaacag aactgttgtc agaaacagga gtaaaatcag
     2701 aaacaggatt gataccggaa acatctttcc aggaaggagt gccgatccgc catgtattat
     2761 ccaattcttt cggcttcgga ggaaacgact cgtcgctcct cttttccgca acgaattttc
     2821 ccaaacgaac gaacctttaa gtttttgagc ctatgcagcc agtttatatt caacgcatcg
     2881 cttctatcca tccacaagga aatcattcac aagaaaataa tccgaaagta aatgattcgc
     2941 tcgatgttgc agcaaaccgt ccttttcttc aggcttgtga acccgattat aaggatatta
     3001 ttgccaatgc aactttgcgc aggcgcatga gccgtattgt gaaaatggga gtggcttgcg
     3061 gattggaatg tatgggcgaa ctatctcccg agaagatagg gggaattatc acagccacag
     3121 ggctgggctg cctggttgat acggaaaagt ttctgaacaa cctgttagat aatgaagagc
     3181 ggatgctgaa tcctactcct tttattcagt cgacattcaa tacaattggt gcacaaatag
     3241 cactgattca tcaaatacat gcctataaca tgacttatgt tcaccgggga ctaagttttg
     3301 aaagcgcttt gctggatgcc atgatgaaaa tagaagaagg aagcgagaat atactggtgg
     3361 gagccatgga cgaaatgaca gaaaccagtt acatcattca gcaacgcttg ggactgctga
     3421 aaggaataga agccggagaa ggcgctcaat tcttcctatt aagccgggaa gccggagagc
     3481 atccgttagc agaaatacga ggacttgaaa ctttcacggg acaacatacg acagaagaaa
     3541 tcagttcccg aattattcgt tttttacaac gaaacggatt agagtgtcag ggtattcaat
     3601 ggttagttac cggaaagaac aaaaaacaat cccttcaagg tgattaccac gagcaaatca
     3661 ctggttataa gaagagtact ataaatgaag ggaaaagtac gaatcagaga agtattataa
     3721 acggggagag tatcataaat gaaaaagata taataattaa ggagattatg atgaatgaaa
     3781 gcaattctat ctatgaagag cttgaaacca accttttccc ggaaagtatt catcttagtt
     3841 ttaaggacga atgtggagaa tatcctaccg cctcatcgta tgccgtatgg aaagcagtaa
     3901 agacatcaat aaactgtact acccctacca atatactgat ttataatcac caccactcca
     3961 tcaatcactc attgattcta attcggaaaa gcgtatgatg attgtttgcc tccttctatg
     4021 tttattcttg atactgtcct ttctcgttta tgcttcctat agcattcagt cgggaattta
     4081 tctacgatcg ttttgcaaaa aacgtactac ggaaaaagtt gtcgccctga cttttgacga
     4141 cggtcccgat cccattcaaa cgcccaaagt attgaaggta ctaaaagaat atcaggcaac
     4201 tgcctgtttt ttctgtatcg gacacaagat aaaaggaaat gaagccctgt tgaaaagtat
     4261 ggtaacagaa ggtcatctaa ttggaaatca ttcatatagt cattccggtt tatttccgct
     4321 atatggactc tctaaaatga aaaaagacct gcaaacttgt cagtgtgaac tagaacgagt
     4381 aacttcgcag ccggttactt tgtttcgtcc gccattcggt gtcactaatc ctacgattgc
     4441 gaaagctgtc cgacagttag gatacacctc aataggatgg agcatccgta cattagatac
     4501 gcaacagtca gctccggaca aaatacttgc caggattcgg aaacgtcttg aaccgggagc
     4561 catcattctg ttgcacgacc ggatgcccgg cagcgaccag ttagtgaaac aaatactgga
     4621 tttgctaaaa gaacaaggat ataccgttgt ccgtccggac aaactattgg cataaaataa
     4681 aaatgtatga gaactttatt actatactta tcgcttttct tcttgtctat cgccaccgtc
     4741 catgcacaga gcatgaaaaa gatggtgcaa aagaccgagt ttgaaaaccg cctggcaaag
     4801 gaggcacaaa ccgtgaagtc catcgaaagc gattttaccc aagtgaaata tctcgatgta
     4861 ttcgacgaaa aggttacttc caaagggaag ttctactacc aaaagagcaa taaaatctgt
     4921 atggaatact tccgcccaat ggattatctc atcgtgataa acgggagtaa gctcaaaatc
     4981 gtatcggatg gcaagaaaag tattatgaac ctaagttcga acaaaatgat ggcacagatg
     5041 caggatatgc taactgcgtg tatgataggc gacctgtcta agatgtcatc caactaccag
     5101 ctagaatatt ttgaagacgc acgatattat ttggttaaaa ttaagccgac taacaaagca
     5161 gtacaagcct atattgccgg tatcgaaatt tatttggaca agaaagatat gtcggtgcac
     5221 aaactccgtc tgtccgaaac agctacaaac tacacagaat acgaattcta taataaaaag
     5281 ttcaactctc tgaagaatga gacgaagttt gcgattcgtt agcctgacgg ttctgttatt
     5341 cttgggaata caggttcaaa cgtcctgctc tccacgaata agcggggaag gcagtactgt
     5401 gcctcctgtt atcgaactga cacaagggga agaatcacaa aaatacaata tccaactgga
     5461 tttcatgaaa catcacatga gtggtatgct gatagtacgc cgtatgcctg ataacgaaat
     5521 ccggatcgtg gcgtctacct acttcgggtt aagccttttc gatttttctc tgcatgacga
     5581 tcaatttaat gtcaacagct gcattgaacc catgaaaaaa gaaaaggtat tgaaactgtt
     5641 agagatggat ttcaggcgtt tgttcttaaa tggaaaagac gtccgtgtga aagccaccaa
     5701 agacaatgct acccaaaaaa gaaccagtgg aaaaggcttt ggaaaatcag tggtctacat
     5761 taccggcgac actccgggtg aaccggcaca aataaaaatc aaacatccgt ggatacggtt
     5821 aacgatccgt ctggataaac tatctaaaga aatttaatat atgctacttg ataacttcta
     5881 tactatcctt tcctccgagt catcggattc aactacctgg actattcaga tagagttgaa
     5941 tcctgaccac actgtttatc agggacattt tcctgaacat ccggtagttc ccggagtttg
     6001 tctattgcaa cttatcaagg aatgtgcaga aaatattcgt cagcaaaagt tgcaaatagt
     6061 acaagtgtct tcctgcaagt ttctttcggc tatcaatcct atagaaacgc ctcggatagc
     6121 aatcgtactg attctcaaag agacagaaga aggcaagttc cagttacagg cggaaggtac
     6181 tataaaggga aataccgtaa ataaaagcat tgtgaaagag gatattgcaa aagaagaaat
     6241 tgtaaaggag aacacaggaa aagaaagcat tataaaggaa gaaaatataa aagacgaatg
     6301 tttcattaaa ctaaaagctg cacttacccc aaaagcatga aggagcaaat aagtacagcc
     6361 tattggcacg aaaagttgaa acaattaggg atcatcgtca tcatcccgag ttacaacaat
     6421 ggcaagacac tggcagaagt catagcaagt gtacgtcttt atgcaccgga aatccttgtt
     6481 gtcaatgacg gttcaacgga tgaaacacct gaaatactga atcaggaagc taatcttcac
     6541 atcatcaccc accctgtcaa tcaaggaaaa ggagtagcat taaaacatgg actatctttc
     6601 gcaaagaagc aaggattccg atatgccatc accattgatt ccgacggaca gcatttcgct
     6661 tcggacattc ccgtattgat tgaagccata gaaaaggaac cggacacgtt actggtaggc
     6721 tcccgtaatc tgacctcgga caatatgccg ggaaagaata cctttgccaa taagttttcc
     6781 aacttttggt tcaccctcga aaccggtatc aaactacaag atacgcaatc cggctaccgc
     6841 ctctacccta tccaacgaat gaatgtggac aagtggtatt acactgccaa atatgagttc
     6901 gaactggaag cacttgtttt tgcagcatgg ggaggcaatc ccgtaaaaaa tattccggta
     6961 cacgtttatt atccgccaca ggaagaacgg gtttctcatt tccgcccgtt ccgtgatttc
     7021 acccgtatca gtattctgaa tacggtactg gtactcgtca ctttcctttg gattgttcca
     7081 cggaactttt tccgtaaact gacctggaag aattgcaagc agtttttctc caatcacatc
     7141 acccactccc ccgaatctaa cctgcggatt acagcagcca tcatgctcgg cgtatttatg
     7201 ggcatcgttc cggcatgggg atatcaaatg ctgattacgt tgtttttggc acatttgttc
     7261 cgattaaaca aagtcatagc tattgtagca gccaacatta gcatccctcc gatgatacca
     7321 tttttactgt acggaagtta tgtaaccggc tgtaaagtac tgggagaacc tgtaaacctg
     7381 cacttaaacg aactttcttt tgaaaatgta aaatcagtca tagagcaata tttaatagga
     7441 agtgttatct ttgcagtcgt atgcagcata ctggcaggaa ccatcgcgtt cattctgctc
     7501 acggcgtgta ggaaaaaaaa gatatgaccc agttttttat cggactatat gattattttg
     7561 agaggcacaa gattctgttc tatttgtcac tcatcagttg tgtcctgttg atggggttct
     7621 ttgccctgca agtaagattc gaagagaaca tcacacaatt tttccccgac accaaagact
     7681 cccaaaacac aatcaaggta ttcgacaatc tcaaaatcaa ggataagatt atcattatgc
     7741 tatcctcggc agatacctgt caccaggtag aacctgattc cctgatagaa gctgccggac
     7801 aactgcaaca aaccctgact gaaaaagccg gaggaaccct gattaaggga attttcgcac
     7861 aagtagacca aagcctcatc ggaggagcca cagactttgt ctacgagcat ctcccgttat
     7921 tcctgacaga tacggattat caacgattcg attccctatt gacagagaaa ggtatacaag
     7981 ctatcatgca gaagaactat accaatctcc tctctcctgc cggaatcgca ttaagaagtt
     8041 atattctccg ggacccgctc ggactgggaa gtgaagccct gaaacatttg caggatttcc
     8101 agttggaagc caactacgag atctatgacg aacacatctt ttccaaagac ggttccacct
     8161 tgcttatgtt cattaccccg gtattcagca caggcagtac cggaaagaat gacgaactga
     8221 taaaaatact cgaagaagaa ctccaacacg tacagggaga atctcctacc attcgagtcg
     8281 aatatttcgg cggtccctcc gtaggagtct acaacgcccg tcagatcaag aaagatacga
     8341 ttttgacttc ctcactggca ctgcttatca tcatagtgtt tatctcactc gtgtttaaac
     8401 ggaagcgatc gataccattg attattactc cggtactctt cggaggattg ttcgccctgt
     8461 ttctgatttt ctttatcaaa ggaagtatat cggccattgc cgtgggagcc ggttcggcag
     8521 tgatgggtat tgcactaagc tattccatcc acatgttggc acatcagaac catgtttcca
     8581 ccgtgcaaca actgattaaa gagatagcct atccgcttac agtaggtagt ttcaccacca
     8641 tcggcgcatt tatgggattg atattcacca gttccgatct gttacgcgat ttcgggttgt
     8701 tcgcttccct ggcattggtg ggtactactc ttttctgcct catttacctg cctcatttcc
     8761 tgaaaggaca ggcagacgtc aaacagggat gtatattacg catcatcgag aaaataaacg
     8821 catattctta cgaaaagaat aaatggttgg taggcggtat tctcctcatt acagttatct
     8881 gtttgtttac ctcacaaaag gtcggcttca acaacgacat gatgagcctc aactatgaac
     8941 ctcaacacct caaacaatcg gaagagaaat taatgcagct cttcgacagc gacgaaaaga
     9001 cagtgctttt tgtcagcgta ggcaaagaca tgaatcaggc caccgaaact tatgcaatga
     9061 ccaatcagaa gttattggca ctgaaagatc agggactgat taaagactat gcttccgcct
     9121 cacaatttct gatctcgcca caagagcaac agctacgcct gaaaaaatgg aaagactact
     9181 ggacagatga aaagcaacaa caaatccgtg aacaactgga aacagctgcc gctgaatacc
     9241 gtttccgccc gggaagcttc gatccctttt atcaatggct gaaccaacct ttcggtgaat
     9301 atcactacac cgctcaagaa gacgatttat ccggcaagct actgaacgaa tggcaaactt
     9361 ctgccgattc catcaccatg cttatcagcc agatacggat cagcgaccag aataaggaaa
     9421 ccgtatatca gcacttcagc aaagaccagg atgtagtcat cttcgaccgt tcctactttg
     9481 ccaataaatg ggtatctgcc atcaatgacg acttttacct gattctatat atctcttctt
     9541 tcctgatatt cttcgcatta tggttctcct acggacgtat cgaacttacc ttgatgagtt
     9601 tcctcccgat gctagttagc tgggtaatca tcctgggatt gatgggaatt ttggggattg
     9661 agttcaacat catcaacatt atcctgtcca cctttatctt tggaattgga gacgatttca
     9721 gtatcttcat tatggacggg ctacaaaaca aataccgtac aggccaaaag gtactgaatt
     9781 ctcacaaaac agccatcttc ttctctgctt tcaccacagt tgtcggcatg ggagcacttg
     9841 tttttgccaa gcatccggct ttgcaatcca tttcattgat ttccattctc ggcatgatag
     9901 cagtagtgtt ggttgcctat accattcagc cactcatttt ccggttcttc attgcaggac
     9961 ccgcttccaa aggattgccg ccttatacgc ttatcgggct gatacggacc gtattgctct
    10021 tcctgctttt ctttatcggt tgtatcttcc tccgtgtact gatcgctgtc ctttatttgg
    10081 tgcctgtgcg gaaaagcagc aaacaacgtt tggtatgccg actgatacaa atcacctgca
    10141 aagggattct actattggcc actgccgtta aaaaagaaca tatcaacaag gctaacgaac
    10201 gttttcagca tccggcaatt attatcgcca accaccagtc gttcatcgat attctggtat
    10261 tgctgtctct ttcgtctaaa atcctgatgg taaccaatca ttgggtatgg cattctcctt
    10321 tcttcggagc aatcatccgc tatgtcgatt tctattacat aggcgaaggc tacgaacaat
    10381 atatggaacg gatgcggaaa aaagtaaaag agggctactc catcgctatc ttccccgaag
    10441 gtacacgcac ttacaacgga aagatgaagc gtttccacaa aggagctttc tacctggcag
    10501 aaacattgca actggatatt cttccgatcc tcctctacgg caacaacaaa atcattgcaa
    10561 aggcacagcc tttcaatatc cgcaaaggaa tcatctacac ggaaatactt ccccgtatac
    10621 cgggcgacga cctttctttc ggaaccacct accaggaacg caccaaacgc atatccgcgt
    10681 atatgaagga aggttacgcc cgtatctgcc gggaaaagaa cacgacggac aatcctgctt
    10741 tctacgaagc tctgatccaa aactatatat acaaaggacc ggtcgtagaa tggtatatcc
    10801 gtatcaaggt gaagatggaa agaaactatc ggctgttcaa ccgattgatt cccgtccaag
    10861 ggcaaattac agacatcggc tgcggctacg gtccgctctg ttatatgctg tctctgcttt
    10921 ccgaagaccg ggaaatttta ggaattgatt acgatgagga taaaatagcc ttggcacaac
    10981 acggatggtt acgcaacgaa catctccagt tcaggcacgg caacgcattg gaatatccgc
    11041 taccggaaag cgatgtcttt atcctgaacg atatgcttca ctatatgagc tatgaacatc
    11101 aacggacttt gctgttgaaa tgcgctgacc ggctgcgttc gcagggaatg attatcatac
    11161 gcgacggaaa ctcggcaaat acatccaaac accggctgac ccggttcacg gaattgctat
    11221 ccacccgcat cttcaatttc aaccggactg ccggagaatt gcatttcact acagaaaccc
    11281 aactacggga aatagcagtc acctgcggaa tgaatgtaga aatcattcct aatgacaaat
    11341 atacctcgaa cactatttat atattcagaa aaccgaacga acatgagtaa atacgatatc
    11401 atcattatcg gaagcggcct tggcggactg gaatgtggag cgattcttag taaagaagga
    11461 ttcaatgtat gcgtcgtaga gaaaaacacg caattcggcg gatgctttca aacctaccgg
    11521 cgaaaaggac acttattcga tacaggcatt cattatgtag gaagcctgga tgaaggtcaa
    11581 gtgatgaatc agtatttccg ctatttcggc atcatggaca aactaaagct gaaacgtttg
    11641 gacgatgagg ctttcgatac aatctactat aaaggaaaaa catacgatta tgcaatgggg
    11701 tatccgcaat tcatcgaaac gatctgccgg tccttcccgc acgaaaaaga aaacctgaaa
    11761 cgttatgccg aacagcttca gactgttggt aacttgatta gcgtagacca tctgaaacag
    11821 ggcacacttg ccctggaagg aatgaaatac ttctgcacct ccgccgcagg actgattgcg
    11881 gatattactc cggaccctac tttacaaaat gtactggcag gctcggcctt gctctacgga
    11941 ggcttgaaag atgtctccac cttctacgaa catgccatga ttaaccattc ctacatcgaa
    12001 ggagcttatc gttttgtgga cggcagtatg caagtcagcc tggaattgat taacgtgatc
    12061 cgggcgaatg gagggacagt acttaacaac agcgaagcca cccgcatcat tgttgaaaac
    12121 gaaaaagtac agggagtcat catcaacggc gaagagcggt tggaaagcga ctatgtaatt
    12181 tccaacatgc accctcaacg aaccctggag atactggata aaaaccgtag tatcaagaac
    12241 gcctacatat cccgcatccg ttcgctcgaa aacacatacg gcatcttcac gctttatctg
    12301 gtaatgaaaa agaagagcac tccgtaccaa aaccgtaacc tctatctgca tggagatcac
    12361 aaagtgtggt atgacaagca gctctatccg ggacggacca ccaactgcat gatttcgatg
    12421 caagcctctt ccgaagacag tcaatacgcc agtgttattt ctatcctgac accgatgtat
    12481 atggacgaac tctctgcatg gaaagacacc actcccgaac atcggggaga aagctaccgg
    12541 tccttcaaga aggaaaagac ggaacagctg cttcgcttta tccggagcca tggcattgat
    12601 ttctccgaca acatagaaga gattcacacc accactccgt tgagctatcg cgactatacc
    12661 ggaacggt
//
