LOCUS       gnlProkkaDPMHAFHG_4    15221 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|DPMHAFHG_4.
ACCESSION   gnlProkkaDPMHAFHG_4
VERSION     gnlProkkaDPMHAFHG_4
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2024-11-30 23:35:11
            Original ID  :: gnl|Prokka|DPMHAFHG_4
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 15221
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     CDS             1..189
                     /locus_tag="ctg4_1"
                     /transl_table=11
                     /translation="MYDIAGKGVACEDSFRQAIYVAIDVFRNRQREKVARANPLRKQYY
                     EKRDDSDKLKLDTVDED"
     protocluster    1..15221
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="True"
                     /core_location="[4870:5221]"
                     /cutoff="10000"
                     /detection_rule="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /neighbourhood="10000"
                     /product="RRE-containing"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      4871..5221
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /neighbourhood="10000"
                     /product="RRE-containing"
                     /protocluster_number="1"
     cand_cluster    1..15221
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /kind="single"
                     /product="RRE-containing"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..15221
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="RRE-containing"
                     /region_number="1"
                     /rules="minimum(1, [Bottromycin_Methyltransferase_RRE,
                     Cyanobactin_D_RRE, Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /tool="antismash"
     CDS             199..1440
                     /gene_functions="regulatory (smcogs) SMCOG1112:sigma-54
                     dependent trancsriptional regulator (Score: 390.2; E-value:
                     2.3e-118)"
                     /gene_kind="regulatory"
                     /locus_tag="ctg4_2"
                     /transl_table=11
                     /translation="MTKAEIQQVKQRFGIIGNTEALSRAIDVAIQVAPTDLSVLITGES
                     GVGKESFPQIIHQYSRRKHGQYIAVNCGAIPEGTIDSELFGHEKGAFTGAIGERKGYFG
                     EADGGTIFLDEVGELPMSTQARLLRVLESGEFMKVGSSKVQKTDVRVVAATNVNLTQAI
                     AEGRFREDLYYRLNTVPIQIPPLRERGDDVLLLFRKFSADFAEKYRMPAIQLTEDAKKE
                     LLAYPWPGNVRQLKNITEQISIIETNREISAAILQNYLPAQNTQRLPALMGTRESKGFE
                     SEREILYSVLFDMRQEVAELKKMVHNLMAERAGQVGQVGQMGTVVTTPVVTAHQPSVPA
                     IIHTMQPTVCKDDDDIQDTEEYVEESPLSLDEVEKEMIRKALERHHGKRKSAAKDLNIS
                     ERTLYRKIKEYELD"
     CDS             1427..1954
                     /locus_tag="ctg4_3"
                     /transl_table=11
                     /translation="MNWIKKIIRPLLLFGLPLVVIACTVSYKFNGSSINYDKVKTISIA
                     DFPIKSEYVYAPLATKFNEDLKDIFIRQTRLQLLKPNQNADLQIDGEITGYNQYNQAVS
                     ADGYSSETKLTITVNVRFVNNTNHAEDFEQQFSAFRTYDSSQLLTAVQDGLIAEMSKEI
                     TDQIFNATVANW"
     CDS             1960..2733
                     /locus_tag="ctg4_4"
                     /transl_table=11
                     /translation="MTSVNFQQWIQHPETLNRDTLYELRNLLARYPYFQSLRLLYLKNL
                     YILHDISFGGELRKAVLYIADRRQLFRLIEGDRYDVQARKKGVPLTEVLKDEPSVDRTL
                     ALIDAFLSTAPEEVTARTSFDYSMDYTSYLLEETPATEQPAEETPKLKGYELIDDFIEK
                     SESDSPLCMKPLREEMPSSPTSSDELTEEETMKEEEEDDSCFTETLAKIYVKQQRYSKA
                     LEIIKKLSLKYPKKNAYFADQIRFLEKLIINANSK"
     CDS             2740..3135
                     /locus_tag="ctg4_5"
                     /transl_table=11
                     /translation="MYLLFVILMVIAALLMCFIVLIQNSKGGGLASGFSSSNAIMGVRK
                     TTDFLEKATWGLAIFMVVMSIATAYVVPRSAVAKDAVLEQAQKEQQTNPYNLPAGTAAP
                     QTEAPATNAPATETPAPAAETPAPAAE"
     CDS             3385..4773
                     /gene_functions="transport (smcogs) SMCOG1106:major
                     facilitator transporter (Score: 92.3; E-value: 4e-28)"
                     /gene_kind="transport"
                     /locus_tag="ctg4_6"
                     /transl_table=11
                     /translation="MTEHLKQKLNDSAVLRWSVLALVAFTMLCGYFLTDVMSPLKPMLE
                     KELLWDSLDYGFFTSAYGWFNVFLLMLIFGGIILDKMGVRFTGMGACLLMVFGCGLKYY
                     AISTTFPEGAMLFGFKTQVTLAALGYAIFGVGVEIAGITVSKIIVKWFKGKEMALAMGL
                     EMATARIGTTLAMVLTVPLADFFGSTDESGTFHTNIPAPILFCLIMLCVGTIAFFLYTF
                     YDKKLDASLDAEGLEPEEPFRMKDIVYIITNKGFWLIALLCVLFYSAVFPFIKYAADLM
                     VQKYNVDPKLAGTIPGLLPIGAIILTPLFGSLYDRIGKGATLMIIGSVMLIFVHTMFAL
                     PILNIWWFATIIMIILGFAFSLVPSAMWPSVPKIIPEKQLGTAYALIFWVQNWGLMGVP
                     LLIGWVLNTYCKGPVVDGAQTYDYTLPMAIFALFGVLALIVALMLKAENKKKGYGLEEA
                     NIQK"
     CDS             4871..5221
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RRE-containing: PqqD_RRE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF05402"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg4_7"
                     /sec_met_domain="PqqD_RRE (E-value: 7e-11, bitscore: 34.4,
                     seeds: 9, tool: rule-based-clusters)"
                     /sec_met_domain="PF05402 (E-value: 2.5e-17, bitscore: 55.6,
                     seeds: 461, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAAKEKINLLEVIPCRSEHITAEREGETIVLSFPRFKYPWMQRFL
                     VPKGMSKELHVKLEEHGTAVWELIDGKRNVREIIEKLADHFQNEEGYESRVSAYLSQMQ
                     KDGFIKLVIPVA"
     CDS             complement(5240..5524)
                     /locus_tag="ctg4_8"
                     /transl_table=11
                     /translation="MVGEGHAFDMIRRIKEGREASRLRRERANDKLKHLNRANEPYPLP
                     NTTPEEMERIIHDSEKKKEKDSNYFVWGTLIIMGVLIAIAVILWAVFIK"
     CDS             complement(5561..6628)
                     /locus_tag="ctg4_9"
                     /transl_table=11
                     /translation="MKKLIIAAGLLMTTSAYAQTEVLTGVTRGKDYGVVYSLPKTQIEL
                     EIKANKVNYTPGEFSKYADRYLRLTNVSADPEEYWELASVKVKSVGVPNSETTYFVKLK
                     DKTVAPLMELTEDGIVKTINVPYSNSSVGKKVAPAPAVLQKKANPREFLTEEILMASST
                     AKMAELVAKEIYNIRESKNALLRGQADNMPSDGAQLKIMLDNLNAQEEAMTQMFSGTCN
                     KEERTFTVRLTPDKEFNNEVAFRFSKKLGVVANNDLAGTPFYISLKDLKSVKMPQEDGK
                     KKKDLDGIAYNVPGQAMVTLTDGKKKLYEGELPITQFGVIEYLAPVLFNKNSTIKVYFD
                     PNTGGLLKVDREEGK"
     CDS             complement(6702..8213)
                     /locus_tag="ctg4_10"
                     /transl_table=11
                     /translation="MKIFPSSSIKKLDAYTIENEPIASIDLMERAATVLTKAITDRWNT
                     ETPVTIFAGPGNNGGDALAVARMMAEKGYKIEVFLFNTKGELSPDCQTNKELVEMMEEV
                     KFHEISTQFVPPALTPDHLVIDGLFGSGLNKPLSGGFAAVVKYINSSPAMVVAIDIPSG
                     LMGEENTFNVKANIIRADVTFSLQLPKLAFLFAENTEFVGEWELLDIQLSEDGIEEMET
                     NYEMLEIEQIRSLIKPRKQFAHKGNFGHALLIAGSKGMAGASVLAARACLRSGVGLLTV
                     HAPMCNNDILQTSIPEAIVETDINETCFAVPTDTDDYQAVGIGPGLGRNEETEAALLEQ
                     LEHCQTPVVVDADALNILANHRHTLTHLPKGSILTPHPKELERLTGKCQDSYERLMKAC
                     ELARAAHVHIILKGAYSAIITPEGKCFFNPTGNPGMATGGSGDVLTGVILALLAQGYPT
                     EEAAKIGTYIHGLAGDVAQKKQGMIGMIASDIITCLPTAWRLVSE"
     CDS             9436..9660
                     /locus_tag="ctg4_11"
                     /transl_table=11
                     /translation="MMEKTKIGLNAGKVWRILNEKGELSMFDLCRELSLTFEDVALAIG
                     WLAREDKIFLRKREGMLFASIENVEFTFG"
     CDS             9854..11398
                     /gene_functions="transport (smcogs) SMCOG1202:major
                     facilitator transporter (Score: 46.8; E-value: 2.5e-14)"
                     /gene_kind="transport"
                     /locus_tag="ctg4_12"
                     /transl_table=11
                     /translation="MSALKGHPKGLYLIFATSTAERFSYYGMRAIFILFLTQALLFDKE
                     AAASIYGSYTGLVYLTPLIGGYIADKYWGIRRSVFWGAVMMAVGQFLMFMSASTLDNTN
                     LAHWMMYGGLGFLILGNGCFKPTVSSLVGQLYEPGDRRLDAAYTIFYMGVNVGSFAAPL
                     ICGYLGDTGDPHDFKWGFLAAGIMTLFTVVLFETQKNKYLFSPSGEPIGIIPDAKREKK
                     EDKADHISHPKMDKRTKVRNTLVITILTIALIAFFNYAFEGDWVSIGIFTACIVFPVLI
                     LLDGSLTKIERSRIFVIYIVAFFVIFFWAAYEQAGASLTLFASEQTNRDIFGWEMPASW
                     FQSFNPLFVVVLAYIMPGVWGFLNKRKMEPASPTKQAIGLLLLSLGYLFICFGVKDAVP
                     GVKVSMIWLTGLYFIHTMGEIALSPIGLSMVNKLSPLRFASLMMGIWYLSTATANKFAG
                     MLSGLYPEAGKVKSIFGYQIATMYDFFMVFVVMSGVASLILFLLSKKLQKMMHGVE"
     CDS             11439..11975
                     /locus_tag="ctg4_13"
                     /transl_table=11
                     /translation="MDTIQIKDKLFTVSIKEQEIQKEVIRVANEINRDLAGKNPLFLSV
                     LNGSFMFTADLLKHITIPCEISFVKLASYQGITSTGVIKEVIGLNEDIAGRTIVIVEDI
                     VDTGLTMQRLLETLGTRNPEAIHIASLLVKPEKLKVNLNIEYVAMEIPNDFIVGYGLDY
                     DGFGRNYPDIYTVVD"
     CDS             12035..12604
                     /locus_tag="ctg4_14"
                     /transl_table=11
                     /translation="MLNIVIFGAPGSGKGTQSERIVEKYGINHISTGDVLRAEIKNGTE
                     LGKTAKGYIDQGQLIPDELMIDILASVFDSFKDSKGVIFDGFPRTIAQAEALKKMLAER
                     GQDVSVMVDLDVPEEELMVRLIKRGKDSGRADDNEETIKKRLHVYHSQTAPLIDWYKNE
                     KKYQHINGLGTMEGIFAEICEAIDKL"
     CDS             12694..13848
                     /locus_tag="ctg4_15"
                     /transl_table=11
                     /translation="MAESNFVDYVKIYCRSGKGGRGSTHMRREKYCPNGGPDGGDGGRG
                     GHIILRGNRNYWTLLHLKYDRHAMAGHGESGSKGRSFGKDGADKIIEVPCGTVVYNAET
                     GEYLCDVTEDGQEVVLLKGGRGGQGNWHFKTATRQAPRFAQPGEPMQEMTVIMELKLLA
                     DVGLVGFPNAGKSTLLSSISAAKPKIADYPFTTLEPNLGIVSYHGGKSFVMADIPGIIE
                     GASQGKGLGLRFLRHIERNSLLLFMVPADSDDIRKEYEVLLNELRTFNPEMLDKQRVLA
                     VTKSDMLDQELMDEIEPTLPEGIPHVFISSVSGLGISVLKDILWEELNKESNKIEDIVH
                     RPKDVTRLQQELKDMGEDEDIVYEYEEDGDDDIDYEYEEDWEEE"
     CDS             13845..14657
                     /locus_tag="ctg4_16"
                     /transl_table=11
                     /translation="MISLTKHNELKGYKSLDAYPEVAHFVTTRHGGISTGAYGSFNCSP
                     YTNDSCVNVNRNQNWLFQCMNHQIKELFIPEQSHGCASLIINESFFKESLERRRLLLRG
                     MDALITNVPGYCVCVTTADCVPVLLYDKKQHVVAAVHAGWKGTVKHIVSHVMDNMTQKF
                     GTQGEDVIACIGPSISLESFEVGDEVYDAFEESGFDMSLISMKKKETGKYHIDLWEANR
                     IELLNRRVPAEQIEVAGICTYIHHDEFFSARRLGIDSGRTLSGIMIRK"
ORIGIN
        1 gcatacgata ttgcaggcaa gggagtggct tgtgaagatt ctttccgcca ggcaatctat
       61 gttgccatcg acgtgttccg taatcgtcag cgtgaaaaag tggctcgtgc caatccgttg
      121 cgtaaacagt attacgagaa acgtgacgat agtgataaac tgaagctgga tacagtagac
      181 gaagattaaa aacgagtgat gacgaaagca gagatacaac aagtgaaaca gcgttttggt
      241 attattggaa atactgaagc attgtcgcgc gccatagatg ttgccattca ggtagctcct
      301 accgatttgt ctgtgctgat taccggagaa agtggagtcg gaaaagaaag ttttccgcag
      361 attattcatc aatatagccg gaggaagcac ggacagtata ttgctgtcaa ctgtggcgct
      421 attccggaag gtacgattga ttccgaactg ttcggacatg agaaaggtgc gtttaccggt
      481 gcgattggcg aacggaaagg gtactttggc gaagctgacg gtggtactat ttttcttgat
      541 gaagtagggg agttgccgat gtctacccag gcacgtttgc tccgtgtact ggagagtggc
      601 gagtttatga aagtaggttc gtccaaagta caaaaaacgg atgtgcgtgt ggtggcagct
      661 accaacgtca atctgacaca agcgattgca gaaggacgtt tccgtgaaga tttatattac
      721 cggttgaata cggtgcctat ccaaataccg cctttgcgtg aacgtggtga cgatgtactt
      781 ttgttgttcc gtaagttttc cgcagacttt gcagagaaat atcggatgcc tgctattcag
      841 ttgacggagg atgcgaagaa agagttgtta gcttacccgt ggcccggaaa cgtgcgtcag
      901 ttgaagaaca tcaccgagca aatatctatc attgaaacca atagggagat ctctgctgct
      961 atcttgcaga attatcttcc cgcacaaaat acgcaacgtc ttcccgcgct gatgggaacg
     1021 cgtgagagta aaggctttga gagcgaacgg gagattcttt attccgttct gttcgatatg
     1081 cgccaggaag tggcggagct gaagaagatg gtgcacaacc tgatggcgga acgtgccgga
     1141 caggtggggc aggtaggaca aatgggaacg gtggttacta ctccggtagt gacggcgcat
     1201 caaccttcgg tacctgctat tattcacacc atgcagccta cggtttgcaa ggatgatgat
     1261 gacatacaag acacggaaga atatgtagaa gaatctcctt tgtcactgga cgaagtggag
     1321 aaagaaatga tacgcaaggc acttgagagg catcatggaa agcggaagag tgcggccaag
     1381 gacttgaata tttccgagcg tacactttat agaaaaataa aagaatatga attggattaa
     1441 gaaaataata cgccctttgt tactgttcgg cttgccgttg gtagtcattg cgtgcactgt
     1501 ttcctataag tttaacggat cgtctatcaa ttatgataag gtaaagacca tttcgatagc
     1561 cgacttcccg atcaagtcgg agtatgtata tgctccgttg gcaaccaaat tcaatgagga
     1621 cctgaaagat atcttcatcc ggcagacccg tctgcaactg ctcaagccga atcagaatgc
     1681 ggacttgcag attgacggag aaatcacagg atacaatcag tacaaccagg cagtatctgc
     1741 cgacggttac tcttcggaga cgaagttgac tattaccgtc aatgtacgtt ttgtcaacaa
     1801 caccaatcat gccgaagact ttgaacaaca gttttctgcg ttccgtacct acgactctag
     1861 ccagttgctg actgccgtac aggacggatt gattgctgaa atgtctaaag agatcaccga
     1921 ccaaattttt aatgcaactg tagcaaactg gtaatataaa tgacttctgt taactttcaa
     1981 caatggattc agcatcccga gacgctgaat agggatactt tgtacgaact gcgcaatctt
     2041 cttgcgaggt atccgtattt tcagtcactt cgtctgctgt atctgaagaa tctgtatatt
     2101 ctccatgata ttagtttcgg tggagaactg cggaaagcag ttctttacat tgcagacaga
     2161 cggcagttgt tccggttgat tgaaggtgac cgctatgatg tgcaagcacg gaaaaaggga
     2221 gtacctctca cggaggtact gaaagacgaa ccatctgtag accgcacatt agcattgatc
     2281 gacgctttct tgtccacagc ccccgaagaa gtgactgccc gcaccagctt cgactattcg
     2341 atggattaca cctcttatct tttggaggag actccggcca cggaacagcc ggccgaagaa
     2401 acgcccaaac tcaaaggcta cgaactgatt gacgacttta tagaaaagag cgagagcgac
     2461 tctcccctct gcatgaaacc tttaagagaa gaaatgccat cttcgccaac ctcttcggac
     2521 gaacttaccg aagaagaaac gatgaaggaa gaagaggaag atgacagctg ttttacggaa
     2581 actttggcaa aaatctatgt taaacagcaa cgatattcaa aagctcttga aataattaaa
     2641 aaattaagct tgaaatatcc aaaaaaaaat gcttactttg cagaccaaat cagatttttg
     2701 gagaaattga ttattaacgc taattcaaaa taactaaaaa tgtacttatt attcgttatc
     2761 ttaatggtta ttgcagcctt gttgatgtgt ttcatcgtgc tgattcagaa ctcaaaagga
     2821 ggcggacttg cttctggttt ctcttcatct aacgccatca tgggcgtgcg caagactaca
     2881 gattttctgg aaaaagcaac atggggctta gctatcttca tggtggtaat gagcattgct
     2941 actgcttatg tagttcctcg ctctgctgtt gctaaagacg cagtgttgga acaggcacag
     3001 aaagaacaac agactaaccc gtataactta cccgcaggta cggctgcgcc gcaaactgaa
     3061 gctcctgcta ccaatgcacc tgctacagaa actccggcac cggctgctga aactcctgct
     3121 cctgcagcag agtaattcac tctgtcgtca ggtaagactt tggggtaaaa ccattaatgg
     3181 gaaggtgcag acgaatgctg catttctttg atatttaagt gcggattacg cagattacac
     3241 ggattttcaa tcttccgcgt ggtcagtgta atccgcactt aactttttct tgtaaaaaca
     3301 atctcttttt gatagaaaca aacgagattt aactaccttt gttggtcgta tgaagattat
     3361 taactactat ttttaaatat aacaatgaca gaacatttga aacagaaatt gaatgactcc
     3421 gccgtactcc gatggagtgt tctagcatta gtcgcattta ctatgctatg cggctatttc
     3481 ctcaccgacg taatgtctcc tctaaaaccc atgcttgaga aagaactact atgggacagt
     3541 ctggattatg gtttcttcac aagcgcttac gggtggttta atgtattcct gttgatgctg
     3601 atcttcggtg gtatcatttt ggataagatg ggagttcgtt tcaccggaat gggggcttgc
     3661 ttattgatgg tgtttggttg tggattgaaa tactatgcga tttctactac ttttccggaa
     3721 ggtgccatgc tcttcggatt caaaacacag gtaaccctgg ctgcattggg gtatgctatc
     3781 ttcggtgtag gtgtggaaat tgccggtatc acagtttcca agattatcgt aaaatggttc
     3841 aagggtaagg aaatggcatt ggctatggga cttgaaatgg ctacggcacg tatcggaaca
     3901 actctggcaa tggtgcttac ggttcctttg gccgactttt tcggatctac ggatgagagt
     3961 ggcacattcc ataccaatat tcctgctcct attctgtttt gtctgattat gttgtgcgtg
     4021 ggtacgattg ctttcttcct ttatactttc tatgataaga agttggatgc ttctttggat
     4081 gcagagggat tggagccgga agagccgttc cgtatgaaag atattgtgta tatcattacc
     4141 aataaaggat tctggttgat tgcattacta tgtgtattgt tctactcggc tgtattcccc
     4201 tttatcaagt atgctgccga cttgatggtg cagaagtata atgtagatcc gaagttggcg
     4261 ggaacgattc ccggattgtt gccgattggt gcgattatcc tgactccgtt gttcggctcg
     4321 ctttatgacc gtatcggtaa gggagctacg ttgatgataa tcggatcagt gatgcttatt
     4381 tttgtgcata cgatgttcgc tctgcctata ctgaatatat ggtggtttgc tactatcatc
     4441 atgattatat tgggatttgc cttctcgttg gtgccttcag ctatgtggcc gtctgttccg
     4501 aagattattc cggaaaaaca gttgggtacc gcatacgcat tgattttctg ggtacagaac
     4561 tggggattga tgggtgttcc tttgttgatc ggatgggtgt tgaatactta ttgtaaaggt
     4621 ccggtagtag acggtgcaca gacttatgac tacacgttgc cgatggctat ttttgctctc
     4681 tttggtgtgc ttgctctgat tgtggctttg atgttgaagg cagagaacaa gaagaaggga
     4741 tacggtctgg aagaggcgaa tatccaaaag taactaggaa attcaatacc taaagtaaca
     4801 aaggaatttt gtatcaaggt gtaaacaaaa gggtatcagt atgaatactc tgaaataaaa
     4861 aataagaagt atggctgcca aagagaaaat caacctgtta gaggtcattc cctgtcgcag
     4921 tgaacatatt acagcagaaa gggaagggga gacaattgtg ctctcctttc cccgttttaa
     4981 atatccgtgg atgcaacgct tccttgtgcc gaaaggaatg tcgaaagaac ttcatgtgaa
     5041 attggaagaa cacggtacgg ctgtatggga actgatagat ggaaaacgca atgttcgtga
     5101 gattatagaa aaactcgcag accactttca aaatgaagag ggctacgagt cgcgtgtatc
     5161 ggcttatctt tctcaaatgc agaaagatgg atttataaaa ctggtgatac cagtcgcata
     5221 aataggaact tattattatt tatttgataa atacagccca aagtatgacg gcaattgcta
     5281 tcaggacccc catgataata agcgttcccc aaacaaaata attgctgtct ttctctttct
     5341 ttttctccga gtcgtggatg atacgttcca tttcttcggg agtggtgttg ggtagtggat
     5401 aaggttcgtt tgcacggttt agatgcttca acttatcgtt agcacgttca cgacgtaggc
     5461 gggaagcttc ccgtccctct tttattcggc gtatcatgtc gaatgcatgt ccttcaccaa
     5521 ccatattctt tgttttttag aagttcactt ccttgttttt ctatttccct tcttctctgt
     5581 ccactttgag caatcctccc gtattcggat caaaataaac tttgatggta gaattcttat
     5641 tgaacaaaac cggagccaga tattctatca caccgaattg agtaatagga agctcacctt
     5701 cgtaaagttt ctttttaccg tcggtcagtg taaccatagc ttgtccgggt acgttgtagg
     5761 cgattccatc caaatctttc ttcttcttac cgtcttcctg tggcatcttg acagatttca
     5821 ggtctttcag actgatataa aacggagttc ctgccaaatc attgttggca actacaccta
     5881 acttcttcga gaagcggaaa gcaacttcat tgttgaattc cttgtcaggg gtaaggcgga
     5941 cagtgaatgt tctttcttct ttgttgcagg tgccggagaa catttgcgtc atggcttctt
     6001 cctgtgcatt cagattgtcg agcataatct taagctgtgc tccgtctgaa ggcatattgt
     6061 cagcctgtcc gcgcaataag gcatttttgc tttcgcggat gttatagatt tctttagcca
     6121 ccagctcggc catcttggcg gtagagctag ccatcagaat ctcctcggtc aggaattcgc
     6181 gaggattcgc tttcttttgg aggactgcgg gagcgggagc aacttttttg cctacactgc
     6241 tattgctgta aggaacattg atcgttttca caatgccatc ctctgtcagt tccataagcg
     6301 gtgctactgt cttatccttc aattttacga aatacgtagt ttcgctgttg ggcacaccta
     6361 cggatttcac ttttacgcta gccagttccc agtactcttc aggatcggcg gagacgttgg
     6421 tcagtcgcag gtaacgatca gcatatttgc tgaattctcc cggagtatag ttgactttgt
     6481 tggcttttat ttcaagttct atttgggttt tgggaagact gtaaaccact ccatagtctt
     6541 ttcctcgggt aacccctgtc agtacttcgg tttgtgcata ggcggacgtt gtcataagta
     6601 gtcctgctgc tataattaac tttttcatat tcggttcttt tttaactggt tttgaaaaca
     6661 aagttaatga agttattgaa aaaactgtaa gttcttaact tttattcgct tacaagtcgc
     6721 catgctgtcg gcagacaggt gataatatcg cttgcgatca ttccgatcat tccttgcttc
     6781 ttttgagcga catcgcccgc caatccgtga atgtaagtgc cgattttagc ggcttcttcg
     6841 gtgggataac cttgggcaag cagtgccagg attactccgg tcagtacgtc accgctacct
     6901 ccggttgcca ttcccggatt tccggttggg ttgaagaaac atttaccttc tggggtgata
     6961 atggcggaat aggctccttt taaaataatg tgaacatggg cggcacgagc caattcgcaa
     7021 gccttcatca gacgttcgta agagtcttgg catttgccgg tcagacgttc cagttctttc
     7081 ggatgcgggg tgaggatgga acccttcggc aggtgggtaa gggtatggcg gtggttggca
     7141 aggatattaa gtgcgtcggc atccactaca acaggagtct ggcaatgttc cagttgctcc
     7201 aataaggcag cttccgtttc ctcgtttcgt cccagtcccg gaccgatgcc gactgcttga
     7261 tagtcgtccg tgtcggtagg tacggcaaaa caggtttcgt tgatgtcggt ttctacgatt
     7321 gcttcgggta tggaggtctg caagatgtcg ttgttgcaca ttggtgcatg aacagtcagc
     7381 aaccctactc ccgaacggag gcaggcacgg gcagcgagaa cagaggctcc tgccattcct
     7441 tttgaaccgg caatcaatag tgcatgaccg aagtttccct tgtgggcaaa ctgtttgcgt
     7501 ggcttgatga gtgaacggat ttgctctatt tccaacattt cgtagttcgt ttccatctct
     7561 tcaataccgt cttcgctcaa ttggatatcc aacaattccc attctccgac aaattctgtg
     7621 ttttctgcga aaagaaaggc gagcttcggc agttgcagac tgaaagttac gtcggcacgg
     7681 ataatattag cttttacgtt gaatgtattt tcttctccca tcagtccgga agggatgtcg
     7741 atggctacta ccatggcagg ggaggaattg atgtatttca ctacggcagc gaatccgccg
     7801 ctcaacggtt tgttcaggcc tgaaccgaat aatccgtcga ttaccagatg gtcgggcgtc
     7861 agggcgggag gtacgaattg ggtactgatc tcgtggaatt ttacttcttc catcatttct
     7921 accagttctt tattggtctg gcagtcgggt gaaagttctc ctttcgtgtt gaagagaaat
     7981 acctcgattt tatatccttt ttcagccatc atgcgggcta cggcgagagc gtctccgcca
     8041 ttattccccg gtccggcaaa gatagtgacc ggcgtttccg tattccatct gtctgtgatg
     8101 gcttttgtta atacggttgc tgcacgttcc atcagatcga ttgatgcaat aggttcgttc
     8161 tcaatggtat aagcgtccaa tttcttgata ctgctgcttg gaaatatttt cattgcgatg
     8221 ttcttttagt tttcggatta caaatgtaca tgattcttct gacttttccc gtttgttgtg
     8281 ggaagaaaac cataattgca acttttaatt catcattagt tctatctttg ggtcagagaa
     8341 atatctgctt ttgaactatt aagtgttaga ataactccgc caaaaaataa ttcaatgcag
     8401 caccattatg aacttacttt tatttctcct gaaaaagatt tctggttctt cgtcaaattt
     8461 ggtggtaaat tctttatctc tttatttcca agttaataat tatccctttt tactcacttt
     8521 cataagaaaa tataggcact gactgaatta gctaaatgag cggagaaaaa cttaccacca
     8581 aatttgacga agaaccagat ttcttcattt catttctcat attctcattg tttttcgata
     8641 aacgaaagct aatcaaatag atatcttatg agaaacactt tttcgaaacg gtatttctca
     8701 taagttctcc catattttgg ctcaaaagcc gccttattct catagtattt cagggtattt
     8761 ctcatagtca aaagccattt gttcttcctt ttttctttca gcctgcctta tttttatcag
     8821 gaaatgaagc tactatttag ataaaatagt ggctttttgc ttgaagatgc tcattggtct
     8881 cgattgtccc atatattgtg ggaaagtttt ccttcaatat acgggaatac tttcccacaa
     8941 aataagggaa tactttccca agccttaggg aatcttttcc cacaatatgt ggaactaaga
     9001 cactgtgtat ggaagcaagc aaaaggaata catagtttta tttattcaat gtcagcttcc
     9061 ggcacactac actatgagaa atgaagcaaa atccgggtta ttttgcgaag aaactatgag
     9121 aaatacctgt tttaaaatca tttctcatag cctatcttat tagtttactg ccacttgttt
     9181 cttatttatg agaatatgag aaatgaaaaa tctttttctg tagaggcgcg gatggaaatt
     9241 gtgtttagtt tatcgccata ccttcttaaa caaattttta atgcggttcc ccttattaag
     9301 cctttgatta tttgccgttt ccgataaaaa tgttatcttt ggagatagat aatgtgcatc
     9361 acatcatttt ccagtgctca caatgaaaat gaattaaaat ctaaataacg gattgtttaa
     9421 tcttctaaag tttgcatgat ggaaaagaca aaaattggct tgaatgccgg gaaagtatgg
     9481 cgcatcttaa atgaaaaagg tgaactttca atgttcgatt tgtgccgtga attaagtttg
     9541 acgtttgaag acgtagctct cgctattggt tggctggccc gagaagacaa aatctttttg
     9601 aggaaaagag aaggaatgct ttttgccagt atcgaaaatg tcgaatttac ttttggctaa
     9661 ggtggtagct aacctacatt taagatggat ctccacttta ttatttacac tgctaaaaaa
     9721 gtaatgaagt ggatcagtag gattttttat gctcgttttt actattcccc ctattattct
     9781 gtttgataag agaagcatct aatctacttt ttctgtacct ttgcacccca taaactacta
     9841 aacacataaa ttcatgagtg cattgaaagg gcatccgaaa ggcctttatt tgattttcgc
     9901 gacaagcacg gcagaacgtt tcagttatta cggtatgcgt gcgatcttta ttcttttcct
     9961 gacgcaggca ttattgtttg acaaagaagc ggcagcatcc atctacggca gctataccgg
    10021 actagtttat ttaaccccgt tgattggcgg atacattgcc gataaatatt ggggaatccg
    10081 tcgttccgtg ttttggggag cggtgatgat ggcagtcgga caattcctga tgtttatgag
    10141 tgcctccact ttagataata caaaccttgc ccactggatg atgtatggcg gactaggctt
    10201 cctgatcttg ggcaatggtt gcttcaaacc cactgtctct tctctggtag gtcagctcta
    10261 cgaacccgga gacaggcggt tggatgctgc atacaccatt ttttatatgg gagtgaatgt
    10321 aggctctttt gctgctcctt tgatttgtgg ttatctgggt gataccggtg atccgcatga
    10381 ctttaaatgg ggatttcttg cagccggaat catgacactg ttcaccgttg ttcttttcga
    10441 gactcaaaag aataaatatc ttttttctcc ttccggagaa ccgattggta ttatccccga
    10501 tgctaaacgt gaaaagaaag aagacaaggc cgaccatatc tcacacccga agatggacaa
    10561 acgtaccaaa gtacgtaata cccttgtaat cacaattctt accattgctt taatagcctt
    10621 ctttaactat gcatttgaag gcgattgggt gagtatcggc atttttaccg cctgcattgt
    10681 tttccctgtt ctgatcttgt tagacggttc attgaccaaa atagaacgca gccgtatttt
    10741 cgttatctat atagtagcct tctttgtcat cttcttctgg gcagcctacg aacaggcggg
    10801 agcttcttta actctctttg cgtccgaaca gacgaatcgt gacattttcg gttgggaaat
    10861 gccggcttca tggtttcaat ccttcaatcc cctgtttgta gttgtcctgg catatatcat
    10921 gccgggtgta tggggtttcc tgaacaagcg aaagatggaa cctgcttctc ctaccaaaca
    10981 agcgattggt ctgttactcc tttctttagg ttatcttttc atctgtttcg gagtgaaaga
    11041 tgctgttccc ggagtgaaag tgagcatgat ttggctgaca ggactttact ttattcatac
    11101 catgggtgaa atagctttgt cgcctatcgg actttcaatg gtaaataaat tgagtccgct
    11161 gcgtttcgcc tccctgatga tgggaatctg gtatctgtct actgccacag ccaataaatt
    11221 tgcgggaatg ttgagcgggc tctatccgga agccggaaaa gtgaagtcaa tctttggtta
    11281 tcagattgct accatgtatg atttctttat ggtattcgtc gtaatgtccg gtgttgcttc
    11341 gttgattctg ttccttctct cgaagaaatt acagaagatg atgcacgggg tagaataaaa
    11401 aatcgtattt ttgcaaggtt atttttaaat taccggttat ggataccatt cagataaaag
    11461 acaaattgtt taccgtttcc attaaggaac aagaaattca gaaagaagtg attcgcgtag
    11521 cgaacgaaat caaccgcgat ttggcaggta agaatccgct tttccttagt gtgttgaacg
    11581 gttcgttcat gtttaccgct gatttattga agcatatcac catcccttgt gaaatctcat
    11641 ttgtgaagtt ggcgtcttat cagggcatca cttccaccgg agtgattaaa gaggtaatcg
    11701 gcctgaatga agacattgcc ggacgtacca ttgtgatcgt agaagatatc gtagacacag
    11761 gactgacgat gcagcgactg ctcgaaacat taggtacacg caatcccgaa gctattcata
    11821 tcgcttctct gttggtgaaa cctgaaaagc tcaaggtaaa cctcaacatt gaatatgtag
    11881 cgatggaaat cccgaacgac tttatcgtag gttacggact ggattatgat ggtttcggac
    11941 gtaattatcc cgatatttat acagtagtag attaatatta aataggtacc agtttaaatg
    12001 gtaaatagta aatcgttaaa ttgtaaataa caaaatgttg aacatcgtaa ttttcggtgc
    12061 tccgggttca ggaaaaggaa cacagagcga acgtatcgta gaaaagtatg gaatcaatca
    12121 catctcgaca ggagatgtat tgcgtgctga aatcaagaat ggcacagaac tgggtaaaac
    12181 agctaaaggt tacatcgacc aaggtcaatt gattcctgat gaattaatga ttgatattct
    12241 ggcaagcgta ttcgacagct tcaaagatag caaaggtgta attttcgacg gtttcccaag
    12301 aacaattgca caagcagaag cattaaagaa aatgttggca gaaagaggac aggacgtttc
    12361 tgtaatggtt gacttggatg ttccggaaga agaactgatg gtacgtctca ttaaacgtgg
    12421 caaggattcc ggtcgtgctg atgataacga agagacaatc aagaaacgtc tgcatgtata
    12481 tcattcacag actgctccac tgatcgactg gtacaagaac gaaaagaaat accaacacat
    12541 caacggcttg ggtactatgg aaggtatctt cgctgaaatc tgcgaagcaa tagataaatt
    12601 gtaataatac aatattataa ataaataagt cagtagccgg agtgttctaa ttaactgctc
    12661 taactactga ctactttaac tctttaaaaa aatatggctg aatcgaattt tgttgattac
    12721 gtaaagatat actgtcgctc gggtaagggc ggaagaggct ctacgcacat gaggcgcgag
    12781 aaatattgtc ctaacggagg tcctgatggg ggcgatggtg gaagaggagg tcatatcatc
    12841 ttgcgcggta accgtaatta ctggacattg ctgcacttga agtatgaccg tcatgcaatg
    12901 gccggtcatg gtgaatcggg gagcaaagga cgtagtttcg gaaaagacgg tgcggataaa
    12961 ataatagaag taccctgcgg aacggtagtt tataatgccg agacagggga gtatctttgt
    13021 gacgtaacag aagacggaca ggaagtggtc ttgctcaaag gcggccgcgg cggtcagggt
    13081 aactggcatt tcaagacggc cacccgtcag gctccgcgtt ttgcgcagcc aggagaaccg
    13141 atgcaggaaa tgaccgttat catggagctg aaactgcttg ccgatgttgg tctggtaggt
    13201 ttcccgaatg cgggaaagtc aactttgctt tcttccattt cggctgccaa accgaaaatt
    13261 gccgattacc cgtttactac actcgaaccc aacttgggca tcgtttccta tcacggtgga
    13321 aaatcctttg tgatggcgga cataccgggt attatcgaag gtgctagcca ggggaaaggt
    13381 ttgggactgc gtttcttgcg tcatatcgag cgtaattcat tactgctgtt tatggttccg
    13441 gcagacagcg acgacattcg taaagaatat gaagtcttgc tgaacgaact gcgtaccttc
    13501 aatcctgaaa tgttggacaa gcaacgtgtg ttggctgtca ccaagagtga tatgctcgat
    13561 caggagttga tggacgagat tgaacctaca ttgccggaag gcattccaca tgtattcata
    13621 tcttctgttt ccggtttggg tatctcggtg ttgaaagaca tcctttggga agaactgaac
    13681 aaggaaagca ataaaataga ggacatcgtt caccgtccga aagacgtgac ccgtctgcaa
    13741 caggaactca aagacatggg cgaagatgaa gacatcgttt atgaatatga ggaagatggc
    13801 gacgatgata tcgattatga gtacgaagaa gattgggaag aagaatgatt tctcttacaa
    13861 aacataacga gttgaaggga tataagtcat tagatgcata tcccgaagta gctcatttcg
    13921 taactacacg tcacggaggt ataagcaccg gagcttacgg ctctttcaac tgttcgcctt
    13981 ataccaacga ctcatgtgtg aacgtcaatc gcaatcagaa ctggttgttt cagtgcatga
    14041 atcatcagat aaaggaatta tttattcctg aacagagtca tggttgcgcc agtctgatta
    14101 tcaatgaatc attttttaaa gaatcattgg aaaggagacg gctacttctg cgaggaatgg
    14161 atgctttgat aacgaatgtg ccgggatatt gcgtttgtgt cacgacagcg gattgtgttc
    14221 ctgtattgct gtacgacaaa aaacaacacg ttgtggctgc cgttcatgcc ggatggaagg
    14281 gaacggtgaa gcatattgtc agtcatgtga tggacaacat gactcaaaag ttcgggacgc
    14341 aaggcgaaga tgtaatagct tgcatcgggc cgagcatttc gctcgaatca tttgaagtag
    14401 gcgatgaagt gtatgatgct tttgaagaaa gcggtttcga tatgtctctt atttctatga
    14461 agaagaagga gacaggcaaa tatcatattg atttgtggga agccaaccgg attgaattac
    14521 tgaatcgcag agtgcctgca gagcagatag aagtggctgg aatctgtacc tatattcatc
    14581 atgatgaatt cttctccgca cgtagactgg gaatagattc cggtcgtaca ttgtcgggaa
    14641 taatgattag aaagtaataa ttggtgtccg ttattgcagg acgctgatga ttggtttatg
    14701 ataagttatg tttgaaataa aagtatctaa agaaataaaa gacgcatgtc cggtttttgc
    14761 cggagccgct gtgtatgctg ttgtgaaaaa tacagcttac agcgaagggc tttggcagga
    14821 aatcgacgct tttaccaagc aactgacttc cacaacacag atggaagaca tcaaacatca
    14881 acccgttatc tttgctaccc gtgaggctta taaacgttgt ggcaaagacc ccggacgtta
    14941 tcgtccgtca gccgaagctc tacgccgccg cctgatgcgt ggaattcctt tatatcagat
    15001 tgatacgttg gtagacctta ttaatttagt gtctcttcgt acgggacatt cgatcggtgg
    15061 ttttgacgcg gacaaaatac aaggtacgca ccttgaactc ggtatcggca aagcaggaga
    15121 accgtttgaa ggtatcggac gcggtgtatt gaatatcgaa ggattacctg tatatcgcga
    15181 ttctttcgga ggaatcggaa ccccgacaag cgatcatgaa c
//
