LOCUS       gnlProkkaAMDCGDEF_22   15219 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|AMDCGDEF_22.
ACCESSION   gnlProkkaAMDCGDEF_22
VERSION     gnlProkkaAMDCGDEF_22
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2024-11-17 04:15:13
            Original ID  :: gnl|Prokka|AMDCGDEF_22
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 15219
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..15219
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="True"
                     /core_location="[4868:5219]"
                     /cutoff="10000"
                     /detection_rule="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /neighbourhood="10000"
                     /product="RRE-containing"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      4869..5219
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /neighbourhood="10000"
                     /product="RRE-containing"
                     /protocluster_number="1"
     cand_cluster    1..15219
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /kind="single"
                     /product="RRE-containing"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..15219
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="RRE-containing"
                     /region_number="1"
                     /rules="minimum(1, [Bottromycin_Methyltransferase_RRE,
                     Cyanobactin_D_RRE, Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /tool="antismash"
     CDS             2..187
                     /locus_tag="ctg22_1"
                     /transl_table=11
                     /translation="MDIAGKGVACEDSFRQAIYVAIDVFRNRQREKVARANPLRKQYYE
                     KRDDSDKLKLDTVDED"
     CDS             197..1438
                     /gene_functions="regulatory (smcogs) SMCOG1112:sigma-54
                     dependent trancsriptional regulator (Score: 390.2; E-value:
                     2.3e-118)"
                     /gene_kind="regulatory"
                     /locus_tag="ctg22_2"
                     /transl_table=11
                     /translation="MTKAEIQQVKQRFGIIGNTEALSRAIDVAIQVAPTDLSVLITGES
                     GVGKESFPQIIHQYSRRKHGQYIAVNCGAIPEGTIDSELFGHEKGAFTGAIGERKGYFG
                     EADGGTIFLDEVGELPMSTQARLLRVLESGEFMKVGSSKVQKTDVRVVAATNVNLTQAI
                     AEGRFREDLYYRLNTVPIQIPPLRERGDDVLLLFRKFSADFAEKYRMPAIQLTEDAKKE
                     LLAYPWPGNVRQLKNITEQISIIETNREISAAILQNYLPAQNTQRLPALMGTRESKGFE
                     SEREILYSVLFDMRQEVAELKKMVHNLMAERAGQVGQVGQMGTVVTTPVVTAHQPSVPA
                     IIHTMQPTVCKDDDDIQDTEEYVEESPLSLDEVEKEMIRKALERHHGKRKSAAKDLNIS
                     ERTLYRKIKEYELD"
     CDS             1425..1952
                     /locus_tag="ctg22_3"
                     /transl_table=11
                     /translation="MNWIKKIIRPLLLFGLPLVVIACTVSYKFNGSSINYDKVKTISIA
                     DFPIKSEYVYAPLATKFNEDLKDIFIRQTRLQLLKPNQNADLQIDGEITGYNQYNQAVS
                     ADGYSSETKLTITVNVRFVNNTNHAEDFEQQFSAFRTYDSSQLLTAVQDGLIAEMSKEI
                     TDQIFNATVANW"
     CDS             1958..2731
                     /locus_tag="ctg22_4"
                     /transl_table=11
                     /translation="MTSVNFQQWIQHPETLNRDTLYELRNLLARYPYFQSLRLLYLKNL
                     YILHDISFGGELRKAVLYIADRRQLFRLIEGDRYDVQARKKGVPLTEVLKDEPSVDRTL
                     ALIDAFLSTAPEEVTARTSFDYSMDYTSYLLEETPATEQPAEETPKLKGYELIDDFIEK
                     SESDSPLCMKPLREEMPSSPTSSDELTEEETMKEEEEDDSCFTETLAKIYVKQQRYSKA
                     LEIIKKLSLKYPKKNAYFADQIRFLEKLIINANSK"
     CDS             2738..3133
                     /locus_tag="ctg22_5"
                     /transl_table=11
                     /translation="MYLLFVILMVIAALLMCFIVLIQNSKGGGLASGFSSSNAIMGVRK
                     TTDFLEKATWGLAIFMVVMSIATAYVVPRSAVAKDAVLEQAQKEQQTNPYNLPAGTAAP
                     QTEAPATNAPATETPAPAAETPAPAAE"
     CDS             3383..4771
                     /gene_functions="transport (smcogs) SMCOG1106:major
                     facilitator transporter (Score: 92.3; E-value: 4e-28)"
                     /gene_kind="transport"
                     /locus_tag="ctg22_6"
                     /transl_table=11
                     /translation="MTEHLKQKLNDSAVLRWSVLALVAFTMLCGYFLTDVMSPLKPMLE
                     KELLWDSLDYGFFTSAYGWFNVFLLMLIFGGIILDKMGVRFTGMGACLLMVFGCGLKYY
                     AISTTFPEGAMLFGFKTQVTLAALGYAIFGVGVEIAGITVSKIIVKWFKGKEMALAMGL
                     EMATARIGTTLAMVLTVPLADFFGSTDESGTFHTNIPAPILFCLIMLCVGTIAFFLYTF
                     YDKKLDASLDAEGLEPEEPFRMKDIVYIITNKGFWLIALLCVLFYSAVFPFIKYAADLM
                     VQKYNVDPKLAGTIPGLLPIGAIILTPLFGSLYDRIGKGATLMIIGSVMLIFVHTMFAL
                     PILNIWWFATIIMIILGFAFSLVPSAMWPSVPKIIPEKQLGTAYALIFWVQNWGLMGVP
                     LLIGWVLNTYCKGPVVDGAQTYDYTLPMAIFALFGVLALIVALMLKAENKKKGYGLEEA
                     NIQK"
     CDS             4869..5219
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RRE-containing: PqqD_RRE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF05402"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg22_7"
                     /sec_met_domain="PqqD_RRE (E-value: 7.1e-11, bitscore:
                     34.4, seeds: 9, tool: rule-based-clusters)"
                     /sec_met_domain="PF05402 (E-value: 2.6e-17, bitscore: 55.6,
                     seeds: 461, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAAKEKINLLEVIPCRSEHITAEREGETIVLSFPRFKYPWMQRFL
                     VPKGMSKELHVKLEEHGTAVWELIDGKRNVREIIEKLADHFQNEEGYESRVSAYLSQMQ
                     KDGFIKLVIPVA"
     CDS             complement(5238..5522)
                     /locus_tag="ctg22_8"
                     /transl_table=11
                     /translation="MVGEGHAFDMIRRIKEGREASRLRRERANDKLKHLNRANEPYPLP
                     NTTPEEMERIIHDSEKKKEKDSNYFVWGTLIIMGVLIAIAVILWAVFIK"
     CDS             complement(5559..6626)
                     /locus_tag="ctg22_9"
                     /transl_table=11
                     /translation="MKKLIIAAGLLMTTSAYAQTEVLTGVTRGKDYGVVYSLPKTQIEL
                     EIKANKVNYTPGEFSKYADRYLRLTNVSADPEEYWELASVKVKSVGVPNSETTYFVKLK
                     DKTVAPLMELTEDGIVKTINVPYSNSSVGKKVAPAPAVLQKKANPREFLTEEILMASST
                     AKMAELVAKEIYNIRESKNALLRGQADNMPSDGAQLKIMLDNLNAQEEAMTQMFSGTCN
                     KEERTFTVRLTPDKEFNNEVAFRFSKKLGVVANNDLAGTPFYISLKDLKSVKMPQEDGK
                     KKKDLDGIAYNVPGQAMVTLTDGKKKLYEGELPITQFGVIEYLAPVLFNKNSTIKVYFD
                     PNTGGLLKVDREEGK"
     CDS             complement(6700..8211)
                     /locus_tag="ctg22_10"
                     /transl_table=11
                     /translation="MKIFPSSSIKKLDAYTIENEPIASIDLMERAATVLTKAITDRWNT
                     ETPVTIFAGPGNNGGDALAVARMMAEKGYKIEVFLFNTKGELSPDCQTNKELVEMMEEV
                     KFHEISTQFVPPALTPDHLVIDGLFGSGLNKPLSGGFAAVVKYINSSPAMVVAIDIPSG
                     LMGEENTFNVKANIIRADVTFSLQLPKLAFLFAENTEFVGEWELLDIQLSEDGIEEMET
                     NYEMLEIEQIRSLIKPRKQFAHKGNFGHALLIAGSKGMAGASVLAARACLRSGVGLLTV
                     HAPMCNNDILQTSIPEAIVETDINETCFAVPTDTDDYQAVGIGPGLGRNEETEAALLEQ
                     LEHCQTPVVVDADALNILANHRHTLTHLPKGSILTPHPKELERLTGKCQDSYERLMKAC
                     ELARAAHVHIILKGAYSAIITPEGKCFFNPTGNPGMATGGSGDVLTGVILALLAQGYPT
                     EEAAKIGTYIHGLAGDVAQKKQGMIGMIASDIITCLPTAWRLVSE"
     CDS             9434..9658
                     /locus_tag="ctg22_11"
                     /transl_table=11
                     /translation="MMEKTKIGLNAGKVWRILNEKGELSMFDLCRELSLTFEDVALAIG
                     WLAREDKIFLRKREGMLFASIENVEFTFG"
     CDS             9852..11396
                     /gene_functions="transport (smcogs) SMCOG1202:major
                     facilitator transporter (Score: 46.8; E-value: 2.5e-14)"
                     /gene_kind="transport"
                     /locus_tag="ctg22_12"
                     /transl_table=11
                     /translation="MSALKGHPKGLYLIFATSTAERFSYYGMRAIFILFLTQALLFDKE
                     AAASIYGSYTGLVYLTPLIGGYIADKYWGIRRSVFWGAVMMAVGQFLMFMSASTLDNTN
                     LAHWMMYGGLGFLILGNGCFKPTVSSLVGQLYEPGDRRLDAAYTIFYMGVNVGSFAAPL
                     ICGYLGDTGDPHDFKWGFLAAGIMTLFTVVLFETQKNKYLFSPSGEPIGIIPDAKREKK
                     EDKADHISHPKMDKRTKVRNTLVITILTIALIAFFNYAFEGDWVSIGIFTACIVFPVLI
                     LLDGSLTKIERSRIFVIYIVAFFVIFFWAAYEQAGASLTLFASEQTNRDIFGWEMPASW
                     FQSFNPLFVVVLAYIMPGVWGFLNKRKMEPASPTKQAIGLLLLSLGYLFICFGVKDAVP
                     GVKVSMIWLTGLYFIHTMGEIALSPIGLSMVNKLSPLRFASLMMGIWYLSTATANKFAG
                     MLSGLYPEAGKVKSIFGYQIATMYDFFMVFVVMSGVASLILFLLSKKLQKMMHGVE"
     CDS             11437..11973
                     /locus_tag="ctg22_13"
                     /transl_table=11
                     /translation="MDTIQIKDKLFTVSIKEQEIQKEVIRVANEINRDLAGKNPLFLSV
                     LNGSFMFTADLLKHITIPCEISFVKLASYQGITSTGVIKEVIGLNEDIAGRTIVIVEDI
                     VDTGLTMQRLLETLGTRNPEAIHIASLLVKPEKLKVNLNIEYVAMEIPNDFIVGYGLDY
                     DGFGRNYPDIYTVVD"
     CDS             12033..12602
                     /locus_tag="ctg22_14"
                     /transl_table=11
                     /translation="MLNIVIFGAPGSGKGTQSERIVEKYGINHISTGDVLRAEIKNGTE
                     LGKTAKGYIDQGQLIPDELMIDILASVFDSFKDSKGVIFDGFPRTIAQAEALKKMLAER
                     GQDVSVMVDLDVPEEELMVRLIKRGKDSGRADDNEETIKKRLHVYHSQTAPLIDWYKNE
                     KKYQHINGLGTMEGIFAEICEAIDKL"
     CDS             12692..13846
                     /locus_tag="ctg22_15"
                     /transl_table=11
                     /translation="MAESNFVDYVKIYCRSGKGGRGSTHMRREKYCPNGGPDGGDGGRG
                     GHIILRGNRNYWTLLHLKYDRHAMAGHGESGSKGRSFGKDGADKIIEVPCGTVVYNAET
                     GEYLCDVTEDGQEVVLLKGGRGGQGNWHFKTATRQAPRFAQPGEPMQEMTVIMELKLLA
                     DVGLVGFPNAGKSTLLSSISAAKPKIADYPFTTLEPNLGIVSYHGGKSFVMADIPGIIE
                     GASQGKGLGLRFLRHIERNSLLLFMVPADSDDIRKEYEVLLNELRTFNPEMLDKQRVLA
                     VTKSDMLDQELMDEIEPTLPEGIPHVFISSVSGLGISVLKDILWEELNKESNKIEDIVH
                     RPKDVTRLQQELKDMGEDEDIVYEYEEDGDDDIDYEYEEDWEEE"
     CDS             13843..14655
                     /locus_tag="ctg22_16"
                     /transl_table=11
                     /translation="MISLTKHNELKGYKSLDAYPEVAHFVTTRHGGISTGAYGSFNCSP
                     YTNDSCVNVNRNQNWLFQCMNHQIKELFIPEQSHGCASLIINESFFKESLERRRLLLRG
                     MDALITNVPGYCVCVTTADCVPVLLYDKKQHVVAAVHAGWKGTVKHIVSHVMDNMTQKF
                     GTQGEDVIACIGPSISLESFEVGDEVYDAFEESGFDMSLISMKKKETGKYHIDLWEANR
                     IELLNRRVPAEQIEVAGICTYIHHDEFFSARRLGIDSGRTLSGIMIRK"
ORIGIN
        1 atacgatatt gcaggcaagg gagtggcttg tgaagattct ttccgccagg caatctatgt
       61 tgccatcgac gtgttccgta atcgtcagcg tgaaaaagtg gctcgtgcca atccgttgcg
      121 taaacagtat tacgagaaac gtgacgatag tgataaactg aagctggata cagtagacga
      181 agattaaaaa cgagtgatga cgaaagcaga gatacaacaa gtgaaacagc gttttggtat
      241 tattggaaat actgaagcat tgtcgcgcgc catagatgtt gccattcagg tagctcctac
      301 cgatttgtct gtgctgatta ccggagaaag tggagtcgga aaagaaagtt ttccgcagat
      361 tattcatcaa tatagccgga ggaagcacgg acagtatatt gctgtcaact gtggcgctat
      421 tccggaaggt acgattgatt ccgaactgtt cggacatgag aaaggtgcgt ttaccggtgc
      481 gattggcgaa cggaaagggt actttggcga agctgacggt ggtactattt ttcttgatga
      541 agtaggggag ttgccgatgt ctacccaggc acgtttgctc cgtgtactgg agagtggcga
      601 gtttatgaaa gtaggttcgt ccaaagtaca aaaaacggat gtgcgtgtgg tggcagctac
      661 caacgtcaat ctgacacaag cgattgcaga aggacgtttc cgtgaagatt tatattaccg
      721 gttgaatacg gtgcctatcc aaataccgcc tttgcgtgaa cgtggtgacg atgtactttt
      781 gttgttccgt aagttttccg cagactttgc agagaaatat cggatgcctg ctattcagtt
      841 gacggaggat gcgaagaaag agttgttagc ttacccgtgg cccggaaacg tgcgtcagtt
      901 gaagaacatc accgagcaaa tatctatcat tgaaaccaat agggagatct ctgctgctat
      961 cttgcagaat tatcttcccg cacaaaatac gcaacgtctt cccgcgctga tgggaacgcg
     1021 tgagagtaaa ggctttgaga gcgaacggga gattctttat tccgttctgt tcgatatgcg
     1081 ccaggaagtg gcggagctga agaagatggt gcacaacctg atggcggaac gtgccggaca
     1141 ggtggggcag gtaggacaaa tgggaacggt ggttactact ccggtagtga cggcgcatca
     1201 accttcggta cctgctatta ttcacaccat gcagcctacg gtttgcaagg atgatgatga
     1261 catacaagac acggaagaat atgtagaaga atctcctttg tcactggacg aagtggagaa
     1321 agaaatgata cgcaaggcac ttgagaggca tcatggaaag cggaagagtg cggccaagga
     1381 cttgaatatt tccgagcgta cactttatag aaaaataaaa gaatatgaat tggattaaga
     1441 aaataatacg ccctttgtta ctgttcggct tgccgttggt agtcattgcg tgcactgttt
     1501 cctataagtt taacggatcg tctatcaatt atgataaggt aaagaccatt tcgatagccg
     1561 acttcccgat caagtcggag tatgtatatg ctccgttggc aaccaaattc aatgaggacc
     1621 tgaaagatat cttcatccgg cagacccgtc tgcaactgct caagccgaat cagaatgcgg
     1681 acttgcagat tgacggagaa atcacaggat acaatcagta caaccaggca gtatctgccg
     1741 acggttactc ttcggagacg aagttgacta ttaccgtcaa tgtacgtttt gtcaacaaca
     1801 ccaatcatgc cgaagacttt gaacaacagt tttctgcgtt ccgtacctac gactctagcc
     1861 agttgctgac tgccgtacag gacggattga ttgctgaaat gtctaaagag atcaccgacc
     1921 aaatttttaa tgcaactgta gcaaactggt aatataaatg acttctgtta actttcaaca
     1981 atggattcag catcccgaga cgctgaatag ggatactttg tacgaactgc gcaatcttct
     2041 tgcgaggtat ccgtattttc agtcacttcg tctgctgtat ctgaagaatc tgtatattct
     2101 ccatgatatt agtttcggtg gagaactgcg gaaagcagtt ctttacattg cagacagacg
     2161 gcagttgttc cggttgattg aaggtgaccg ctatgatgtg caagcacgga aaaagggagt
     2221 acctctcacg gaggtactga aagacgaacc atctgtagac cgcacattag cattgatcga
     2281 cgctttcttg tccacagccc ccgaagaagt gactgcccgc accagcttcg actattcgat
     2341 ggattacacc tcttatcttt tggaggagac tccggccacg gaacagccgg ccgaagaaac
     2401 gcccaaactc aaaggctacg aactgattga cgactttata gaaaagagcg agagcgactc
     2461 tcccctctgc atgaaacctt taagagaaga aatgccatct tcgccaacct cttcggacga
     2521 acttaccgaa gaagaaacga tgaaggaaga agaggaagat gacagctgtt ttacggaaac
     2581 tttggcaaaa atctatgtta aacagcaacg atattcaaaa gctcttgaaa taattaaaaa
     2641 attaagcttg aaatatccaa aaaaaaatgc ttactttgca gaccaaatca gatttttgga
     2701 gaaattgatt attaacgcta attcaaaata actaaaaatg tacttattat tcgttatctt
     2761 aatggttatt gcagccttgt tgatgtgttt catcgtgctg attcagaact caaaaggagg
     2821 cggacttgct tctggtttct cttcatctaa cgccatcatg ggcgtgcgca agactacaga
     2881 ttttctggaa aaagcaacat ggggcttagc tatcttcatg gtggtaatga gcattgctac
     2941 tgcttatgta gttcctcgct ctgctgttgc taaagacgca gtgttggaac aggcacagaa
     3001 agaacaacag actaacccgt ataacttacc cgcaggtacg gctgcgccgc aaactgaagc
     3061 tcctgctacc aatgcacctg ctacagaaac tccggcaccg gctgctgaaa ctcctgctcc
     3121 tgcagcagag taattcactc tgtcgtcagg taagactttg gggtaaaacc attaatggga
     3181 aggtgcagac gaatgctgca tttctttgat atttaagtgc ggattacgca gattacacgg
     3241 attttcaatc ttccgcgtgg tcagtgtaat ccgcacttaa ctttttcttg taaaaacaat
     3301 ctctttttga tagaaacaaa cgagatttaa ctacctttgt tggtcgtatg aagattatta
     3361 actactattt ttaaatataa caatgacaga acatttgaaa cagaaattga atgactccgc
     3421 cgtactccga tggagtgttc tagcattagt cgcatttact atgctatgcg gctatttcct
     3481 caccgacgta atgtctcctc taaaacccat gcttgagaaa gaactactat gggacagtct
     3541 ggattatggt ttcttcacaa gcgcttacgg gtggtttaat gtattcctgt tgatgctgat
     3601 cttcggtggt atcattttgg ataagatggg agttcgtttc accggaatgg gggcttgctt
     3661 attgatggtg tttggttgtg gattgaaata ctatgcgatt tctactactt ttccggaagg
     3721 tgccatgctc ttcggattca aaacacaggt aaccctggct gcattggggt atgctatctt
     3781 cggtgtaggt gtggaaattg ccggtatcac agtttccaag attatcgtaa aatggttcaa
     3841 gggtaaggaa atggcattgg ctatgggact tgaaatggct acggcacgta tcggaacaac
     3901 tctggcaatg gtgcttacgg ttcctttggc cgactttttc ggatctacgg atgagagtgg
     3961 cacattccat accaatattc ctgctcctat tctgttttgt ctgattatgt tgtgcgtggg
     4021 tacgattgct ttcttccttt atactttcta tgataagaag ttggatgctt ctttggatgc
     4081 agagggattg gagccggaag agccgttccg tatgaaagat attgtgtata tcattaccaa
     4141 taaaggattc tggttgattg cattactatg tgtattgttc tactcggctg tattcccctt
     4201 tatcaagtat gctgccgact tgatggtgca gaagtataat gtagatccga agttggcggg
     4261 aacgattccc ggattgttgc cgattggtgc gattatcctg actccgttgt tcggctcgct
     4321 ttatgaccgt atcggtaagg gagctacgtt gatgataatc ggatcagtga tgcttatttt
     4381 tgtgcatacg atgttcgctc tgcctatact gaatatatgg tggtttgcta ctatcatcat
     4441 gattatattg ggatttgcct tctcgttggt gccttcagct atgtggccgt ctgttccgaa
     4501 gattattccg gaaaaacagt tgggtaccgc atacgcattg attttctggg tacagaactg
     4561 gggattgatg ggtgttcctt tgttgatcgg atgggtgttg aatacttatt gtaaaggtcc
     4621 ggtagtagac ggtgcacaga cttatgacta cacgttgccg atggctattt ttgctctctt
     4681 tggtgtgctt gctctgattg tggctttgat gttgaaggca gagaacaaga agaagggata
     4741 cggtctggaa gaggcgaata tccaaaagta actaggaaat tcaataccta aagtaacaaa
     4801 ggaattttgt atcaaggtgt aaacaaaagg gtatcagtat gaatactctg aaataaaaaa
     4861 taagaagtat ggctgccaaa gagaaaatca acctgttaga ggtcattccc tgtcgcagtg
     4921 aacatattac agcagaaagg gaaggggaga caattgtgct ctcctttccc cgttttaaat
     4981 atccgtggat gcaacgcttc cttgtgccga aaggaatgtc gaaagaactt catgtgaaat
     5041 tggaagaaca cggtacggct gtatgggaac tgatagatgg aaaacgcaat gttcgtgaga
     5101 ttatagaaaa actcgcagac cactttcaaa atgaagaggg ctacgagtcg cgtgtatcgg
     5161 cttatctttc tcaaatgcag aaagatggat ttataaaact ggtgatacca gtcgcataaa
     5221 taggaactta ttattattta tttgataaat acagcccaaa gtatgacggc aattgctatc
     5281 aggaccccca tgataataag cgttccccaa acaaaataat tgctgtcttt ctctttcttt
     5341 ttctccgagt cgtggatgat acgttccatt tcttcgggag tggtgttggg tagtggataa
     5401 ggttcgtttg cacggtttag atgcttcaac ttatcgttag cacgttcacg acgtaggcgg
     5461 gaagcttccc gtccctcttt tattcggcgt atcatgtcga atgcatgtcc ttcaccaacc
     5521 atattctttg ttttttagaa gttcacttcc ttgtttttct atttcccttc ttctctgtcc
     5581 actttgagca atcctcccgt attcggatca aaataaactt tgatggtaga attcttattg
     5641 aacaaaaccg gagccagata ttctatcaca ccgaattgag taataggaag ctcaccttcg
     5701 taaagtttct ttttaccgtc ggtcagtgta accatagctt gtccgggtac gttgtaggcg
     5761 attccatcca aatctttctt cttcttaccg tcttcctgtg gcatcttgac agatttcagg
     5821 tctttcagac tgatataaaa cggagttcct gccaaatcat tgttggcaac tacacctaac
     5881 ttcttcgaga agcggaaagc aacttcattg ttgaattcct tgtcaggggt aaggcggaca
     5941 gtgaatgttc tttcttcttt gttgcaggtg ccggagaaca tttgcgtcat ggcttcttcc
     6001 tgtgcattca gattgtcgag cataatctta agctgtgctc cgtctgaagg catattgtca
     6061 gcctgtccgc gcaataaggc atttttgctt tcgcggatgt tatagatttc tttagccacc
     6121 agctcggcca tcttggcggt agagctagcc atcagaatct cctcggtcag gaattcgcga
     6181 ggattcgctt tcttttggag gactgcggga gcgggagcaa cttttttgcc tacactgcta
     6241 ttgctgtaag gaacattgat cgttttcaca atgccatcct ctgtcagttc cataagcggt
     6301 gctactgtct tatccttcaa ttttacgaaa tacgtagttt cgctgttggg cacacctacg
     6361 gatttcactt ttacgctagc cagttcccag tactcttcag gatcggcgga gacgttggtc
     6421 agtcgcaggt aacgatcagc atatttgctg aattctcccg gagtatagtt gactttgttg
     6481 gcttttattt caagttctat ttgggttttg ggaagactgt aaaccactcc atagtctttt
     6541 cctcgggtaa cccctgtcag tacttcggtt tgtgcatagg cggacgttgt cataagtagt
     6601 cctgctgcta taattaactt tttcatattc ggttcttttt taactggttt tgaaaacaaa
     6661 gttaatgaag ttattgaaaa aactgtaagt tcttaacttt tattcgctta caagtcgcca
     6721 tgctgtcggc agacaggtga taatatcgct tgcgatcatt ccgatcattc cttgcttctt
     6781 ttgagcgaca tcgcccgcca atccgtgaat gtaagtgccg attttagcgg cttcttcggt
     6841 gggataacct tgggcaagca gtgccaggat tactccggtc agtacgtcac cgctacctcc
     6901 ggttgccatt cccggatttc cggttgggtt gaagaaacat ttaccttctg gggtgataat
     6961 ggcggaatag gctcctttta aaataatgtg aacatgggcg gcacgagcca attcgcaagc
     7021 cttcatcaga cgttcgtaag agtcttggca tttgccggtc agacgttcca gttctttcgg
     7081 atgcggggtg aggatggaac ccttcggcag gtgggtaagg gtatggcggt ggttggcaag
     7141 gatattaagt gcgtcggcat ccactacaac aggagtctgg caatgttcca gttgctccaa
     7201 taaggcagct tccgtttcct cgtttcgtcc cagtcccgga ccgatgccga ctgcttgata
     7261 gtcgtccgtg tcggtaggta cggcaaaaca ggtttcgttg atgtcggttt ctacgattgc
     7321 ttcgggtatg gaggtctgca agatgtcgtt gttgcacatt ggtgcatgaa cagtcagcaa
     7381 ccctactccc gaacggaggc aggcacgggc agcgagaaca gaggctcctg ccattccttt
     7441 tgaaccggca atcaatagtg catgaccgaa gtttcccttg tgggcaaact gtttgcgtgg
     7501 cttgatgagt gaacggattt gctctatttc caacatttcg tagttcgttt ccatctcttc
     7561 aataccgtct tcgctcaatt ggatatccaa caattcccat tctccgacaa attctgtgtt
     7621 ttctgcgaaa agaaaggcga gcttcggcag ttgcagactg aaagttacgt cggcacggat
     7681 aatattagct tttacgttga atgtattttc ttctcccatc agtccggaag ggatgtcgat
     7741 ggctactacc atggcagggg aggaattgat gtatttcact acggcagcga atccgccgct
     7801 caacggtttg ttcaggcctg aaccgaataa tccgtcgatt accagatggt cgggcgtcag
     7861 ggcgggaggt acgaattggg tactgatctc gtggaatttt acttcttcca tcatttctac
     7921 cagttcttta ttggtctggc agtcgggtga aagttctcct ttcgtgttga agagaaatac
     7981 ctcgatttta tatccttttt cagccatcat gcgggctacg gcgagagcgt ctccgccatt
     8041 attccccggt ccggcaaaga tagtgaccgg cgtttccgta ttccatctgt ctgtgatggc
     8101 ttttgttaat acggttgctg cacgttccat cagatcgatt gatgcaatag gttcgttctc
     8161 aatggtataa gcgtccaatt tcttgatact gctgcttgga aatattttca ttgcgatgtt
     8221 cttttagttt tcggattaca aatgtacatg attcttctga cttttcccgt ttgttgtggg
     8281 aagaaaacca taattgcaac ttttaattca tcattagttc tatctttggg tcagagaaat
     8341 atctgctttt gaactattaa gtgttagaat aactccgcca aaaaataatt caatgcagca
     8401 ccattatgaa cttactttta tttctcctga aaaagatttc tggttcttcg tcaaatttgg
     8461 tggtaaattc tttatctctt tatttccaag ttaataatta tcccttttta ctcactttca
     8521 taagaaaata taggcactga ctgaattagc taaatgagcg gagaaaaact taccaccaaa
     8581 tttgacgaag aaccagattt cttcatttca tttctcatat tctcattgtt tttcgataaa
     8641 cgaaagctaa tcaaatagat atcttatgag aaacactttt tcgaaacggt atttctcata
     8701 agttctccca tattttggct caaaagccgc cttattctca tagtatttca gggtatttct
     8761 catagtcaaa agccatttgt tcttcctttt ttctttcagc ctgccttatt tttatcagga
     8821 aatgaagcta ctatttagat aaaatagtgg ctttttgctt gaagatgctc attggtctcg
     8881 attgtcccat atattgtggg aaagttttcc ttcaatatac gggaatactt tcccacaaaa
     8941 taagggaata ctttcccaag ccttagggaa tcttttccca caatatgtgg aactaagaca
     9001 ctgtgtatgg aagcaagcaa aaggaataca tagttttatt tattcaatgt cagcttccgg
     9061 cacactacac tatgagaaat gaagcaaaat ccgggttatt ttgcgaagaa actatgagaa
     9121 atacctgttt taaaatcatt tctcatagcc tatcttatta gtttactgcc acttgtttct
     9181 tatttatgag aatatgagaa atgaaaaatc tttttctgta gaggcgcgga tggaaattgt
     9241 gtttagttta tcgccatacc ttcttaaaca aatttttaat gcggttcccc ttattaagcc
     9301 tttgattatt tgccgtttcc gataaaaatg ttatctttgg agatagataa tgtgcatcac
     9361 atcattttcc agtgctcaca atgaaaatga attaaaatct aaataacgga ttgtttaatc
     9421 ttctaaagtt tgcatgatgg aaaagacaaa aattggcttg aatgccggga aagtatggcg
     9481 catcttaaat gaaaaaggtg aactttcaat gttcgatttg tgccgtgaat taagtttgac
     9541 gtttgaagac gtagctctcg ctattggttg gctggcccga gaagacaaaa tctttttgag
     9601 gaaaagagaa ggaatgcttt ttgccagtat cgaaaatgtc gaatttactt ttggctaagg
     9661 tggtagctaa cctacattta agatggatct ccactttatt atttacactg ctaaaaaagt
     9721 aatgaagtgg atcagtagga ttttttatgc tcgtttttac tattccccct attattctgt
     9781 ttgataagag aagcatctaa tctacttttt ctgtaccttt gcaccccata aactactaaa
     9841 cacataaatt catgagtgca ttgaaagggc atccgaaagg cctttatttg attttcgcga
     9901 caagcacggc agaacgtttc agttattacg gtatgcgtgc gatctttatt cttttcctga
     9961 cgcaggcatt attgtttgac aaagaagcgg cagcatccat ctacggcagc tataccggac
    10021 tagtttattt aaccccgttg attggcggat acattgccga taaatattgg ggaatccgtc
    10081 gttccgtgtt ttggggagcg gtgatgatgg cagtcggaca attcctgatg tttatgagtg
    10141 cctccacttt agataataca aaccttgccc actggatgat gtatggcgga ctaggcttcc
    10201 tgatcttggg caatggttgc ttcaaaccca ctgtctcttc tctggtaggt cagctctacg
    10261 aacccggaga caggcggttg gatgctgcat acaccatttt ttatatggga gtgaatgtag
    10321 gctcttttgc tgctcctttg atttgtggtt atctgggtga taccggtgat ccgcatgact
    10381 ttaaatgggg atttcttgca gccggaatca tgacactgtt caccgttgtt cttttcgaga
    10441 ctcaaaagaa taaatatctt ttttctcctt ccggagaacc gattggtatt atccccgatg
    10501 ctaaacgtga aaagaaagaa gacaaggccg accatatctc acacccgaag atggacaaac
    10561 gtaccaaagt acgtaatacc cttgtaatca caattcttac cattgcttta atagccttct
    10621 ttaactatgc atttgaaggc gattgggtga gtatcggcat ttttaccgcc tgcattgttt
    10681 tccctgttct gatcttgtta gacggttcat tgaccaaaat agaacgcagc cgtattttcg
    10741 ttatctatat agtagccttc tttgtcatct tcttctgggc agcctacgaa caggcgggag
    10801 cttctttaac tctctttgcg tccgaacaga cgaatcgtga cattttcggt tgggaaatgc
    10861 cggcttcatg gtttcaatcc ttcaatcccc tgtttgtagt tgtcctggca tatatcatgc
    10921 cgggtgtatg gggtttcctg aacaagcgaa agatggaacc tgcttctcct accaaacaag
    10981 cgattggtct gttactcctt tctttaggtt atcttttcat ctgtttcgga gtgaaagatg
    11041 ctgttcccgg agtgaaagtg agcatgattt ggctgacagg actttacttt attcatacca
    11101 tgggtgaaat agctttgtcg cctatcggac tttcaatggt aaataaattg agtccgctgc
    11161 gtttcgcctc cctgatgatg ggaatctggt atctgtctac tgccacagcc aataaatttg
    11221 cgggaatgtt gagcgggctc tatccggaag ccggaaaagt gaagtcaatc tttggttatc
    11281 agattgctac catgtatgat ttctttatgg tattcgtcgt aatgtccggt gttgcttcgt
    11341 tgattctgtt ccttctctcg aagaaattac agaagatgat gcacggggta gaataaaaaa
    11401 tcgtattttt gcaaggttat ttttaaatta ccggttatgg ataccattca gataaaagac
    11461 aaattgttta ccgtttccat taaggaacaa gaaattcaga aagaagtgat tcgcgtagcg
    11521 aacgaaatca accgcgattt ggcaggtaag aatccgcttt tccttagtgt gttgaacggt
    11581 tcgttcatgt ttaccgctga tttattgaag catatcacca tcccttgtga aatctcattt
    11641 gtgaagttgg cgtcttatca gggcatcact tccaccggag tgattaaaga ggtaatcggc
    11701 ctgaatgaag acattgccgg acgtaccatt gtgatcgtag aagatatcgt agacacagga
    11761 ctgacgatgc agcgactgct cgaaacatta ggtacacgca atcccgaagc tattcatatc
    11821 gcttctctgt tggtgaaacc tgaaaagctc aaggtaaacc tcaacattga atatgtagcg
    11881 atggaaatcc cgaacgactt tatcgtaggt tacggactgg attatgatgg tttcggacgt
    11941 aattatcccg atatttatac agtagtagat taatattaaa taggtaccag tttaaatggt
    12001 aaatagtaaa tcgttaaatt gtaaataaca aaatgttgaa catcgtaatt ttcggtgctc
    12061 cgggttcagg aaaaggaaca cagagcgaac gtatcgtaga aaagtatgga atcaatcaca
    12121 tctcgacagg agatgtattg cgtgctgaaa tcaagaatgg cacagaactg ggtaaaacag
    12181 ctaaaggtta catcgaccaa ggtcaattga ttcctgatga attaatgatt gatattctgg
    12241 caagcgtatt cgacagcttc aaagatagca aaggtgtaat tttcgacggt ttcccaagaa
    12301 caattgcaca agcagaagca ttaaagaaaa tgttggcaga aagaggacag gacgtttctg
    12361 taatggttga cttggatgtt ccggaagaag aactgatggt acgtctcatt aaacgtggca
    12421 aggattccgg tcgtgctgat gataacgaag agacaatcaa gaaacgtctg catgtatatc
    12481 attcacagac tgctccactg atcgactggt acaagaacga aaagaaatac caacacatca
    12541 acggcttggg tactatggaa ggtatcttcg ctgaaatctg cgaagcaata gataaattgt
    12601 aataatacaa tattataaat aaataagtca gtagccggag tgttctaatt aactgctcta
    12661 actactgact actttaactc tttaaaaaaa tatggctgaa tcgaattttg ttgattacgt
    12721 aaagatatac tgtcgctcgg gtaagggcgg aagaggctct acgcacatga ggcgcgagaa
    12781 atattgtcct aacggaggtc ctgatggggg cgatggtgga agaggaggtc atatcatctt
    12841 gcgcggtaac cgtaattact ggacattgct gcacttgaag tatgaccgtc atgcaatggc
    12901 cggtcatggt gaatcgggga gcaaaggacg tagtttcgga aaagacggtg cggataaaat
    12961 aatagaagta ccctgcggaa cggtagttta taatgccgag acaggggagt atctttgtga
    13021 cgtaacagaa gacggacagg aagtggtctt gctcaaaggc ggccgcggcg gtcagggtaa
    13081 ctggcatttc aagacggcca cccgtcaggc tccgcgtttt gcgcagccag gagaaccgat
    13141 gcaggaaatg accgttatca tggagctgaa actgcttgcc gatgttggtc tggtaggttt
    13201 cccgaatgcg ggaaagtcaa ctttgctttc ttccatttcg gctgccaaac cgaaaattgc
    13261 cgattacccg tttactacac tcgaacccaa cttgggcatc gtttcctatc acggtggaaa
    13321 atcctttgtg atggcggaca taccgggtat tatcgaaggt gctagccagg ggaaaggttt
    13381 gggactgcgt ttcttgcgtc atatcgagcg taattcatta ctgctgttta tggttccggc
    13441 agacagcgac gacattcgta aagaatatga agtcttgctg aacgaactgc gtaccttcaa
    13501 tcctgaaatg ttggacaagc aacgtgtgtt ggctgtcacc aagagtgata tgctcgatca
    13561 ggagttgatg gacgagattg aacctacatt gccggaaggc attccacatg tattcatatc
    13621 ttctgtttcc ggtttgggta tctcggtgtt gaaagacatc ctttgggaag aactgaacaa
    13681 ggaaagcaat aaaatagagg acatcgttca ccgtccgaaa gacgtgaccc gtctgcaaca
    13741 ggaactcaaa gacatgggcg aagatgaaga catcgtttat gaatatgagg aagatggcga
    13801 cgatgatatc gattatgagt acgaagaaga ttgggaagaa gaatgatttc tcttacaaaa
    13861 cataacgagt tgaagggata taagtcatta gatgcatatc ccgaagtagc tcatttcgta
    13921 actacacgtc acggaggtat aagcaccgga gcttacggct ctttcaactg ttcgccttat
    13981 accaacgact catgtgtgaa cgtcaatcgc aatcagaact ggttgtttca gtgcatgaat
    14041 catcagataa aggaattatt tattcctgaa cagagtcatg gttgcgccag tctgattatc
    14101 aatgaatcat tttttaaaga atcattggaa aggagacggc tacttctgcg aggaatggat
    14161 gctttgataa cgaatgtgcc gggatattgc gtttgtgtca cgacagcgga ttgtgttcct
    14221 gtattgctgt acgacaaaaa acaacacgtt gtggctgccg ttcatgccgg atggaaggga
    14281 acggtgaagc atattgtcag tcatgtgatg gacaacatga ctcaaaagtt cgggacgcaa
    14341 ggcgaagatg taatagcttg catcgggccg agcatttcgc tcgaatcatt tgaagtaggc
    14401 gatgaagtgt atgatgcttt tgaagaaagc ggtttcgata tgtctcttat ttctatgaag
    14461 aagaaggaga caggcaaata tcatattgat ttgtgggaag ccaaccggat tgaattactg
    14521 aatcgcagag tgcctgcaga gcagatagaa gtggctggaa tctgtaccta tattcatcat
    14581 gatgaattct tctccgcacg tagactggga atagattccg gtcgtacatt gtcgggaata
    14641 atgattagaa agtaataatt ggtgtccgtt attgcaggac gctgatgatt ggtttatgat
    14701 aagttatgtt tgaaataaaa gtatctaaag aaataaaaga cgcatgtccg gtttttgccg
    14761 gagccgctgt gtatgctgtt gtgaaaaata cagcttacag cgaagggctt tggcaggaaa
    14821 tcgacgcttt taccaagcaa ctgacttcca caacacagat ggaagacatc aaacatcaac
    14881 ccgttatctt tgctacccgt gaggcttata aacgttgtgg caaagacccc ggacgttatc
    14941 gtccgtcagc cgaagctcta cgccgccgcc tgatgcgtgg aattccttta tatcagattg
    15001 atacgttggt agaccttatt aatttagtgt ctcttcgtac gggacattcg atcggtggtt
    15061 ttgacgcgga caaaatacaa ggtacgcacc ttgaactcgg tatcggcaaa gcaggagaac
    15121 cgtttgaagg tatcggacgc ggtgtattga atatcgaagg attacctgta tatcgcgatt
    15181 ctttcggagg aatcggaacc ccgacaagcg atcatgaac
//
