LOCUS       gnlProkkaIBBNHGCA_290  24912 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|IBBNHGCA_290.
ACCESSION   gnlProkkaIBBNHGCA_290
VERSION     gnlProkkaIBBNHGCA_290
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2024-12-01 00:42:44
            Original ID  :: gnl|Prokka|IBBNHGCA_290
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 24912
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..24912
                     /aStool="rule-based-clusters"
                     /category="PKS"
                     /contig_edge="True"
                     /core_location="[1:4912]"
                     /cutoff="20000"
                     /detection_rule="(APE_KS1 or APE_KS2)"
                     /neighbourhood="20000"
                     /product="arylpolyene"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      2..4912
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(APE_KS1 or APE_KS2)"
                     /neighbourhood="20000"
                     /product="arylpolyene"
                     /protocluster_number="1"
     cand_cluster    1..24912
                     /SMILES=""
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(APE_KS1 or APE_KS2)"
                     /kind="single"
                     /product="arylpolyene"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..24912
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="arylpolyene"
                     /region_number="1"
                     /rules="(APE_KS1 or APE_KS2)"
                     /tool="antismash"
     CDS             complement(2..565)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     arylpolyene: APE_KS2"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg290_1"
                     /sec_met_domain="APE_KS2 (E-value: 7.6e-22, bitscore: 69.7,
                     seeds: 16, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MEYPLNIYITAHTLISSLGFGISENKKAIHDYRSGIRMQEAGRIS
                     DSPILAGMIDSVELEKRAKELLEKRAKELDISSYTRLEQLFILTIQEVISQSGVNLQES
                     DCALLLSTTKGNIDLLSNQEKRTNSDKPSGSVQSTIDNPSFLQELSADSPTFLWKMAER
                     IGHFFEAANQVEVISNACISGVSAL"
     CDS             complement(550..993)
                     /locus_tag="ctg290_2"
                     /transl_table=11
                     /translation="MKRKTNQQIAALTNRTTFRVRFSEIDSMQIVWHGEYVRYFEDGRE
                     AFGKQYGLDYMSIYREGYMVPIVDLTCQFKQSLSFGEEAIIETRYIACEAAKIKFEYVI
                     YRATDQSVVATGSTIQVFLNLNKELELINPPFYLEWKKKWNIL"
     CDS             complement(990..1424)
                     /locus_tag="ctg290_3"
                     /transl_table=11
                     /translation="MNREAVIQGEGILNLIPQRPPIVMVDSFFGFEENRSYSGLTVTTD
                     NLFCEAGRLQEPGIIEHIAQSAAARIGFIYTRQGEKVPLGFIGSVDKLKIYNLPEAGMK
                     LFTEITVVQEVFDITLISAQVKTEEELIAECKMKIFIKKE"
     CDS             complement(1421..2491)
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1042:O-methyltransferase (Score: 126.4; E-value:
                     2.4e-38)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg290_4"
                     /transl_table=11
                     /translation="MQQNKYDKEPLTAVEAQRLAQEIAFGPIVFQVSRLMLKFGIFQLL
                     ADERKGMTQEEISKACGLPSYGAQVLLEASLTIGTVLLREGRYCLAKAGWFLLNDKMVR
                     VNMDFNHDVNYQGMFHLEEAITNGRPEGLKVFGEWSTIYEGLSSLPSQVQKSWFGFDHY
                     YSDCSFDEALAIVFARHPKTLLDVGGNTGRWATKCVSYDDTVEVTIMDLPQQLEMMRQQ
                     TKELPGATRIHGHGANLLDPEVPFPTRFDAIWMSQFLDCFSEEEVTSILTRAARSMNRE
                     SRLYIMETFWNRQKFDTAAYCLTQISLYFTAMANGNSKMYHSDDMQRCIEAAGLEIEEI
                     HDHLGMGHSIVQCRLK"
     CDS             complement(2478..3413)
                     /locus_tag="ctg290_5"
                     /transl_table=11
                     /translation="MSTWKGKTRGGTFGYLFFIYLIKYLGITAAYLFLSLVVLYFIPFA
                     PKATKSTWFYARNILKYNRIHSLKMLLLNYYRLGQILIDKVAIGNGKVNQYQFKFERYP
                     EFLQLLNSEQGVIMIGAHVGNWEIGVPFFDDYGKKINIVMYDAEHRRIKEILEKNGQDK
                     EFKIIPVNEDNLTHVFRITEAINQKEYVCFQGDRYLNKEKLLPGILLGQKAPFPAGPFL
                     LASRMKVPVVFYFAMREPGRTYRFHFIIAEPVVRTKEKKAEMALLEQYTVALEQILKRY
                     PEQWFNYYPFWEPAGKQSPDLKEKQKDATE"
     CDS             complement(3416..3667)
                     /NRPS_PKS="Domain: PP-binding (7-75). E-value: 3.8e-14.
                     Score: 44.9. Matches aSDomain:
                     nrpspksdomains_ctg290_6_PP-binding.1"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PP-binding"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg290_6"
                     /sec_met_domain="PP-binding (E-value: 3.8e-14, bitscore:
                     44.9, seeds: 164, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTNEEIIEKIRTTLAEEFEVDIDVIQPDAPLMETLELDSLDLVDM
                     VVLVEKNFGFNVTGQDFAGIKTFQDFYDLVITRMQEAK"
     aSDomain        complement(3443..3646)
                     /aSDomain="PP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg290_6_PP-binding.1"
                     /evalue="3.80E-14"
                     /label="ctg290_6_PP-binding.1"
                     /locus_tag="ctg290_6"
                     /protein_end="75"
                     /protein_start="7"
                     /score="44.9"
                     /tool="antismash"
                     /translation="EKIRTTLAEEFEVDIDVIQPDAPLMETLELDSLDLVDMVVLVEKN
                     FGFNVTGQDFAGIKTFQDFYDLV"
     CDS             complement(3689..4912)
                     /NRPS_PKS="Domain: PKS_KS(Iterative-KS) (65-405). E-value:
                     1.8e-53. Score: 173.8. Matches aSDomain:
                     nrpspksdomains_ctg290_7_PKS_KS.1"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     arylpolyene: APE_KS1"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1022:Beta-ketoacyl synthase (Score: 296.3; E-value:
                     6.6e-90)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg290_7"
                     /sec_met_domain="APE_KS1 (E-value: 8.6e-159, bitscore:
                     520.4, seeds: 15, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKRVVITGMGIYSCIGKNLDEVKDSLYNGKSGIGIDPVRKELGYF
                     SALTGILERPDLKKLLDRRKRLCLPEQGEYAYLATLEAFRNAGIDEAFLEANEVGILYG
                     NDSSAAPVINAVDIIREKKNTALVGSGSIFQSMNSTVTMNLSVIFKLRGVNFTIAGACA
                     SGSHAIGMGYLLIKSGLQDCILCGGAQEVNPYAVGSFDGLSAFSTQEAEPEKASKPFDK
                     RRDGLIPSGGAASLVLESYESAVKRGAPILAEVIGYGFSSNGDHISVPNVDGPKRSLQM
                     AIKDAGIALEQISYINAHATSTPVGDLNEAKAIAEVFEGHHPYVTSTKSMTGHEMWMAG
                     ASEVIYSTLMMNNGFIAPNLNFEEPDEASAQLNIPTQRVNLEFDTFLSNSFGFGGTNST
                     LIIRQIKE"
     aSDomain        complement(3698..4717)
                     /aSDomain="PKS_KS"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg290_7_PKS_KS.1"
                     /domain_subtypes="Iterative-KS"
                     /evalue="1.80E-53"
                     /label="ctg290_7_PKS_KS.1"
                     /locus_tag="ctg290_7"
                     /protein_end="405"
                     /protein_start="65"
                     /score="173.8"
                     /tool="antismash"
                     /translation="RLCLPEQGEYAYLATLEAFRNAGIDEAFLEANEVGILYGNDSSAA
                     PVINAVDIIREKKNTALVGSGSIFQSMNSTVTMNLSVIFKLRGVNFTIAGACASGSHAI
                     GMGYLLIKSGLQDCILCGGAQEVNPYAVGSFDGLSAFSTQEAEPEKASKPFDKRRDGLI
                     PSGGAASLVLESYESAVKRGAPILAEVIGYGFSSNGDHISVPNVDGPKRSLQMAIKDAG
                     IALEQISYINAHATSTPVGDLNEAKAIAEVFEGHHPYVTSTKSMTGHEMWMAGASEVIY
                     STLMMNNGFIAPNLNFEEPDEASAQLNIPTQRVNLEFDTFLSNSFGFGGTNSTLIIRQI
                     "
     CDS             complement(4939..5667)
                     /NRPS_PKS="Domain: PKS_KR (3-169). E-value: 1.3e-16. Score:
                     52.9. Matches aSDomain: nrpspksdomains_ctg290_8_PKS_KR.1"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) adh_short"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1001:short-chain dehydrogenase/reductase SDR (Score:
                     212.9; E-value: 8.3e-65)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg290_8"
                     /sec_met_domain="adh_short (E-value: 1.6e-35, bitscore:
                     114.6, seeds: 230, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKYALVTGGSRGIGRAVSCKLAEMGYFILINYQSNDAEAEKTLQL
                     VQEKGSNGEIMKFDVTDPAAIALALNNWASQHPDEYIEVLINNAGIRKDNLMLWMTGEE
                     WNKVLDISLNGFFYVTQPLLKNMLVKRYGRIVNIVSLSGIQGMPGQANYSAAKGGVIAA
                     TKALAQEVAKKKVTVNAVAPGFIRTDMTEGIDENEWKKHIPAGRFGTVEEVADLVGFLA
                     SPASSYITGEVISINGGLYT"
     aSDomain        complement(5161..5658)
                     /aSDomain="PKS_KR"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg290_8_PKS_KR.1"
                     /evalue="1.30E-16"
                     /label="ctg290_8_PKS_KR.1"
                     /locus_tag="ctg290_8"
                     /protein_end="169"
                     /protein_start="3"
                     /score="52.9"
                     /specificity="KR activity: inactive"
                     /specificity="KR stereochemistry: C2"
                     /tool="antismash"
                     /translation="ALVTGGSRGIGRAVSCKLAEMGYFILINYQSNDAEAEKTLQLVQE
                     KGSNGEIMKFDVTDPAAIALALNNWASQHPDEYIEVLINNAGIRKDNLMLWMTGEEWNK
                     VLDISLNGFFYVTQPLLKNMLVKRYGRIVNIVSLSGIQGMPGQANYSAAKGGVIAATKA
                     LAQ"
     CDS_motif       complement(5593..5655)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ctg290_8_0001"
                     /evalue="2.90E-04"
                     /label="PKSI-KR_m1"
                     /locus_tag="ctg290_8"
                     /protein_end="25"
                     /protein_start="4"
                     /score="13.5"
                     /tool="antismash"
                     /translation="LVTGGSRGIGRAVSCKLAEMG"
     CDS             complement(5669..7192)
                     /locus_tag="ctg290_9"
                     /transl_table=11
                     /translation="MIADKSINLDTLYKVLFDNEKLELSKECIRKVEESFDFLQSFSSD
                     KIIYGINTGFGPMAQYRIEDQSLIELQYNIIRSHSTGAGKPLPELYVKAAMIARLYTFL
                     QGKSGVHMELVSLLCEFINRGIYPFIPEHGSVGASGDLVQLAHIALTLIGEGEVFYQGK
                     LRDAATVLEENGLQPFSMRIREGLSVTNGTSVMTGIGIVNLIYAKKLLRWSVAASVMMN
                     EIAASYDDFMAQALNEAKHHKGQQEIAAMMREWVSGSKCVLQRENELYNQVHKEKIFEH
                     KVQPYYSLRCVPQILGPIYDELKNAEEVLINEINSACDNPIVDPDTQNIYHGGNFHGDY
                     ISFEMDKLKIAVTKLTMLCERQINYLFHDRINGILPPFVNLGVLGLNYGLQASQFTATS
                     TTAECQTLSNPMYVHSIPNNNDNQDIVSMGTNSALLAKTVIENSYQVMAIQFMGMAQAI
                     DYLKIQDRLSPKSRQVYEEIRSFFPVFTNDTPKYKEIERMMNYLKKENK"
     CDS             complement(7425..7856)
                     /locus_tag="ctg290_10"
                     /transl_table=11
                     /translation="MEEIVFHHTLPIQLRFNDVDKFGHVNNTVYFSFYDLGKTEYFASV
                     CPGVDWEKIGIVVVHIEADFVKQIFASDHIAVQTAVSKIGTKSFHLIQRVIDTETNEVK
                     CICKSVMVTFDLERHESMPLTEEWIEAICKYEERDLLKA"
     CDS             8125..8733
                     /locus_tag="ctg290_11"
                     /transl_table=11
                     /translation="MCYFCVLFLTEINQEMIEDIKKACQVMNEGGVILYPTDTVWGIGC
                     DATNEEAVRRVYEIKKRADSKAMLVLVDSPVKVDFYVQDVPDVAWDLIEVADKPLTIIY
                     SGARNLAPNLLAEDGSVGIRVTNEDFSRRLCQQFRKAIVSTSANVSGQPGAANFSEISD
                     EIKSAVDYIVGFRQDDMNKPKPSSIIKLEKGGVIKIIRE"
     CDS             8734..10527
                     /locus_tag="ctg290_12"
                     /transl_table=11
                     /translation="MKGEKLSLLQRCIKWREANIKEKQFILILSFLVGIFTAFAALILK
                     FFIHQIQNFLTNNFNATEANYLYLVYPVVGIFLAGWFVRNIVKDDISHGVTKILYAISR
                     RQGRIKRHNIWSSTIASAITIGFGGSVGAEAPIVLTGSAIGSNLGSVFKMEHRTLMLLV
                     GCGAAGAIAGIFKAPIAGLVFTLEVLMIDLTMSSLLPLLISAVTAATVSYIVTGTEAMF
                     KFHLDQAFELERIPFVILLGIFCGLISLYFTRAMNSVEGVFGKLNNPYKKLAFGGVMLS
                     VLIFLFPPLYGEGYDTINLLLNGTSAEEWDTVMNNSMFYGYGNLLLVYLMLIILLKVFA
                     SSATNGGGGCGGIFAPSLYLGCIAGFVFSHFSNDFAFSAYLPEKNFALMGMAGVMSGVM
                     HAPLTGVFLIAELTGGYDLFLPLMIVSVSSYLTIIAFEPHSIYSMRLAKKGQLLTHHKD
                     KAVLTLMKMENVVEKDFVVVHPEMDLGELVKAIAASHRNVFPVTDKKTGELLGIVLLDD
                     IRNIMFRQELYHRFTVNKLMISAPAKIFDTDGMEQVMQTFDDTKAWNLPVVDEEGRYQG
                     FVSKSKIFNSYRQVLVHFSED"
     CDS             10561..11532
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1228:methionyl-tRNA formyltransferase (Score: 221.4;
                     E-value: 2.3e-67)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg290_13"
                     /transl_table=11
                     /translation="MKKEDLRIVYMGTPDFAVEALRQLVEGGYNVVGVITMPDKPAGRG
                     HKIQYSPVKQYALEQNLPLLQPEKLKDEAFVEALCEWKADLQIVVAFRMLPEVVWNMPR
                     LGTFNLHASLLPQYRGAAPINWAVINGDTETGITTFFLKHEIDTGEVIQQVRVPIADTD
                     NVEVVHDKLMMLGGKLVLETVDAILNGTVKPIPQEEMAVVGELRPAPKIFKETCRIDWN
                     QPVKKIYDFIRGLSPYPAAWSELIASEKAESVVVKIFESEKVYESHQLAAGTIVTDGKK
                     FMKVAVSDGFVSILSLQLPGKKRLKTDELLRGYHLEDGCKMK"
     CDS             11600..12250
                     /locus_tag="ctg290_14"
                     /transl_table=11
                     /translation="MKPIIAPSILSADFGYLAKDIEMVNRSEAEWVHIDIMDGVFVPNI
                     SFGFPVLKYVAKLSKKPLDVHLMIVNPEKFIPEVKALGAHTMNVHYEACPHLHRVIQQI
                     REAGMQPAVTINPATPVALLQDIIRDVYMVLIMSVNPGFGGQKFIEHSVEKVRELRALI
                     ERTGSKALIEVDGGVNLETGARLVEAGADALVAGNAVFGAQDPVEMIRQLHEL"
     CDS             12259..14406
                     /locus_tag="ctg290_15"
                     /transl_table=11
                     /translation="MNSFYIHRYPFIRLLIPWIAGIFCGDHFFDRSWDPLCGILFFGFF
                     AVLSFALYFLKRYSLRWCFGIAISALCFTGGWLGMTGQLQQAVCSFPKEETVYRVLITD
                     VPQPKEHTYLCQALLKERRDTAGIYPIGHTAVLYLQQDSSASRLKSGDELLISARISPP
                     LNNRNFDEFDYARFLMRKDISGTGYVASGKWTILSSSKPPLSSANPSISLRQDGMNNFD
                     LKSVASSCRRNVVSLYQELGFNGDELAVLSALTIGDKTELSDSVRESYSVAGASHILAL
                     SGLHIGLLYTMIFFILKPIARRGNIGRCVRSVFLLVLLWTFAFFTGLSPSVVRSVSMFS
                     ILAMADMTGREPLSLNTLAVAAWLMLFCNPAWLFDVGFQLSFLAVASILLIQKPIYHLI
                     TVKSRIGKYVWGLMSISVAAQIGTAPLVLFYFSRFSVHFLLTNLVVIPLITIILYAAVV
                     MLLLAPFSWLQIGVAGGVKKLLEGLNFFVRWVEQLPCASIDGIWLYQSEVLGIYIVIAL
                     LTYYFMNRRYRNLQICLFSILLMGTYHATLYWQDRPQTSLVFYNVRGCPAVHCIKSDGQ
                     SWINYMDTLSNEKRLKHMTANYWKRHHLLPPQEITADCRHAELNRQQQIISYHGCRVCV
                     INDNRWRNKSTVSPLYIQYLYLCKGYDGHLEELAQVFSFSYVILDASLSEYRKHLLESE
                     CKKSGLRFISLADEGSVRFLL"
     CDS             14453..15490
                     /locus_tag="ctg290_16"
                     /transl_table=11
                     /translation="MLTKVIEQAKIDHFTKWFERADKIVIVSHVSPDGDAIGSSLGLYH
                     FLDSQEKTVNVIVPNAFPDFLRWMPGSKDILLYDRYKDFADKLIAEADVICCLDFNALK
                     RIDDMADAVAASPARKIMIDHHLYPEDFCKIVMSYPKISSTSELIFRLICRMGYFSDIT
                     KEGAECIYTGMMTDTGGFTYNSNNREIYFIISELLSKGIDKDDIYRKVYNTYSESRLRL
                     MGYVLSNMTVYPDCNSALITLTKAEQSKFNYIKGDSEGFVNIPLSIKNVCFSCFLREDT
                     EKPMIKISLRSVGTFPCNQLAAEFFNGGGHLNASGGEFFGTMEEAKAVFEKALEKYKPL
                     LTAKS"
     CDS             15609..16304
                     /locus_tag="ctg290_17"
                     /transl_table=11
                     /translation="MKKLVFLFLSLLTAGSLFQACDNSKTYAEMLEDEKNAVNKFIKDN
                     DIRVISLEEFERDTVTASKEAGDGYDEYVAFSNGVYMQIVDRGGKEEGENGVEFINEVD
                     TFANNNVICTRYVEKDMMTGEVTCFNVPLEEWMDAPDYYKFPLTFRYVQNASTVYGIVL
                     SGSLEYDLLWVNQGYGTAIPSGWLIALPYLRNNAHVRLIVPSKMGHTTAQQYVNPYFYD
                     IWKFEKAKS"
     CDS             16342..17730
                     /locus_tag="ctg290_18"
                     /transl_table=11
                     /translation="MTLIKSISGIRGTIGGGAGEGLNPLDIVKFTSAYATLIRKTCKAK
                     SNKIVVGRDARISGEMVKNVVVGTLMGMGWDVVDIDLASTPTTELAVTMEGACGGIILT
                     ASHNPKQWNALKLLNEHGEFLNAAEGNEVLRIAEAEEFDYADVDHLGSYRKDLTYNQKH
                     IDSVLALDLVDVEAIKKADFRVAIDCVNSVGGIILPELLERLGVKHVEKLYCEPTGNFQ
                     HNPEPLEKNLGDIMNLMKGGKADVAFVVDPDVDRLAMICENGVMYGEEYTLVTVADYVL
                     KHTPGNTVSNLSSTRALRDVTRKYGMEYSASAVGEVNVVTKMKATNAVIGGEGNGGVIY
                     PASHYGRDALVGIALFLSHLAHEGKKVSELRATYPPYFIAKNRVDLTPEIDVDAILAKV
                     KEIYKNEEINDIDGVKIDFADKWVHLRKSNTEPIIRVYSEASTMEAAEEIGQKIMDVIN
                     ELAK"
     CDS             18546..22505
                     /gene_functions="regulatory (smcogs) SMCOG1287:AraC family
                     transcriptional regulator (Score: 65.3; E-value: 8.2e-20)"
                     /gene_kind="regulatory"
                     /locus_tag="ctg290_19"
                     /transl_table=11
                     /translation="MINTMKMRLIFPFVLLIYSLICQADGGKDSYIFRKVDYQQGLSNS
                     AVLCLFQDNTGLMWFGTYDGVNCYDGRSMEVFRSDFSAPKALSNNVIHSIQQADNNCLW
                     ISTHLGINRLSQNSRQVVGYYDFTDDYYLHSNSKGNTWVVSHGGIFYYNTSYKRFVQIK
                     NLKVPVEDMDKRAFVTDDGVLWIFTQQTGELLQVSQDAFDCDTLSIHSTVSSTNFHAKP
                     IEDVFYQNGVLCFIDSEHDLYVYDISRQSKIYIRNLSSLVQKNGTIAGIALFYEDIIIG
                     FRTNGLVRLRTSQKYKEEVVDRNVRIYSIYRDPHQNVLWVASDGQGTIMYAKKYSIATN
                     LMLNQLSSNLSRQVRSVMTDNSGGLWFGTKGDGLLHIPDYRENEEASAVTVYSPEGKQN
                     VVSYIRWNKEFPVYKLVQSRYMDGFWIGSGDPGLFYYSFEDKALHSVENLPAQPTEIHG
                     IYEENDSVLYVVTAGSGFHKLILEKQAGTIRFKSQKSYHFFHGQREITMFYPMLPEGDS
                     ILWLGSREKGLVRFDKRTEEYKVISLKEMLHKSVDDVLSLYRTKEGLLYVGTTSGLVCL
                     NSNGKQMKATYIGREQGLLNDMIHGVLEDENGLLWLGTNRGLIKYNPINGSSHAYFYSA
                     GVQIGEFSDDAYYMCPYTQELFFGGIDGLLYLDKEVQAAPEFYPDILLRKLTVGHTQVV
                     QGDGDYYTDDGKALQLKGTEVSFALSFVVPDFLSGEDIEYSYQLEGYDKDWTSFSSINE
                     ASYTGVPAGDYIFKVRYKRDVFDTEYRHFSIPVYILSPWYRSVAAYFVYLVIFLLLLGY
                     VIYLLRKNYLQERMMKTLMGTESCRKSETVYTNRRMLEDFTLIYNYCDQLRAENLSYEQ
                     CLEKVSLIRETVMNALLNPDALFLEELKQFFPDRFIVSARMSIQGVSQEVLRTLEEQGI
                     DHSSISSMIPEHLTFPVYKNALYSILYCCYLRITEMKGTHGVIVEMSEQDGKMQLHFSS
                     KDATAKALYEYLSDKASSVTEKDSDHVFAVHLLLGFVRSALERIHAVLRYDDDESGSRL
                     TIIFEPAVLTVAGEQGKKTVLLLEDRDEMTWLISNFLADEYVVHQVKSVQLAFDEIRRS
                     APALLLVDMTMYANAESTFMEYVSRNRTLLSKTAFIPLLTWKVGSAIQRELILWSDSYI
                     VLPYDILFLREVVHNAIYGKREAKQIYMEELGDLAGQIVCTTTEQADFIRKLLKVIEEN
                     LDKEELGSTLIADRMAMSSRQFYRKFKEISNTAPGDLIKSYRMEKAARLLLDEELSIQD
                     VIMEVGISSRSYFYKEFTRRFGMTPKDYREQRKVC"
ORIGIN
        1 ccagtgccga gactccagat atacaggcgt tggagattac ttctacctga ttggctgcct
       61 caaaaaaatg cccgattcgt tctgccattt tccaaagaaa agtcggacta tcggctgata
      121 attcctgtaa aaaggaagga ttatcaattg ttgattgtac agaaccgctt ggcttgtccg
      181 aattagttct tttttcttga ttgctcaata aatcaatatt tcccttcgta gtagagagca
      241 acaaagcaca gtccgactct tgcagattca ctcccgattg ggaaatcact tcctgaatag
      301 tcaatataaa cagttgctct aaccgggtat aagaggaaat atccagctcc tttgcccgct
      361 tttctaatag ttctttagct ctcttttcca actcgacaga atcaatcatc cctgccagaa
      421 tcggactgtc agaaatccgt ccggcttcct gcatacgaat cccgcttcga tagtcatgga
      481 ttgctttttt gttttccgaa ataccgaaac ctaacgaact aatcagcgta tgggctgtga
      541 tgtatatatt taaaggatat tccatttctt tttccattcc agataaaacg gaggattgat
      601 aagctccagt tctttattca ggttcaggaa cacttgtatg gtgcttccgg tggccactac
      661 actctggtcg gtagcccggt agataacgta ttcgaatttt atcttggctg cctcacaggc
      721 aatatagcgt gtttcgataa tcgcttcttc accaaaggac aatgattgct tgaactggca
      781 ggttaaatct acgatgggaa ccatgtagcc ttcccggtaa atgctcatat aatccaaacc
      841 atactgtttg ccgaaagctt cccgcccatc ttcaaagtag cgcacgtact cgccatgcca
      901 tacaatctgc atggagtcaa tttcgctgaa ccgtactctg aaagtagtcc ggttagtcaa
      961 agctgcaatc tgttgatttg ttttccgttt cattcttttt tgataaatat tttcatctta
     1021 cattcagcaa tcagctcttc ttccgttttc acttgtgccg aaataagcgt aatatcgaat
     1081 acctcttgta cgacggtaat ctctgtaaat aatttcattc cggcttccgg caaattgtag
     1141 attttaagtt tgtctaccga accgataaaa cctaacggaa ctttttcacc ctgccgggta
     1201 taaataaacc cgatacgtgc agccgctgat tgtgcgatat gctcaataat tcccggctct
     1261 tgcagtctgc ctgcctcaca aaataaattg tcggtagtga cagtcagtcc ggaatatgaa
     1321 cggttttctt caaatccgaa gaaactgtcc accataacga ttggcggacg ctgtggaatc
     1381 aggttgagta ttccttctcc ttgtatgacg gcttctctgt tcatttcaat ctgcattgta
     1441 cgatgctgtg tcccattcct aaatggtcat gtatctcttc gatttccaat cctgctgctt
     1501 cgatgcatcg ttgcatatcg tccgaatgat acatcttgct gtttccgttt gccatcgctg
     1561 taaaatagag actgatttgt gtcaggcaat aagcggctgt gtcaaatttc tgtcggttcc
     1621 agaaagtctc cataatatac aggcggctct ctcggttcat agaacgggct gcacgggtca
     1681 atatgctggt aacttcttct tccgagaaac aatcgaggaa ctggctcatc caaatagcat
     1741 cgaaccttgt cgggaaaggc acctccggat caagcagatt ggcaccatga ccgtggatac
     1801 gtgtagctcc gggcagctct ttggtttgtt gacgcatcat ctccaattgt tgcggaagat
     1861 ccatgatggt tacttccact gtgtcgtcgt agcttacgca tttggtcgcc cagcggccgg
     1921 tattgcctcc cacatccaat aaagtcttgg gatggcgggc gaagacaatt gccagtgctt
     1981 catcgaacga acaatccgag taataatgat cgaaaccgaa ccagctcttt tgtacttgtg
     2041 aaggcagact tgacaaccct tcatagatag tactccattc accgaatact ttcagtcctt
     2101 caggacgtcc gttggtgatg gcttcttcca gatgaaacat tccctgatag ttgacatcat
     2161 ggttgaagtc catattgaca cgtaccattt tgtcattgag cagaaaccag ccggctttcg
     2221 caaggcagta tcgcccttca cgcaacaata cggtgccgat agtcaatgat gcctccaaca
     2281 atacttgtgc gccataagag ggcagcccac aagctttgct gatttcttct tgcgtcatac
     2341 ctttgcgctc gtcggccaat aactggaaaa ttccgaattt aagcataagg cgtgatacct
     2401 gaaaaacaat aggcccaaaa gctatttctt gtgccaggcg ttgtgcctct accgctgtca
     2461 acggctcttt gtcatattta ttctgttgca tctttttgtt tctcttttaa atccggtgac
     2521 tgctttccgg caggttccca gaatggataa taattgaacc attgttccgg atagcgtttt
     2581 agtatctgtt ccaaagcaac agtatattgt tcgagcagag ccatctccgc tttcttttct
     2641 tttgttcgta ctaccggttc cgctattata aaatgaaaac ggtaagttct tcccggttcc
     2701 ctcattgcaa agtagaatac caccggaact ttcattcgcg aagcgagcag gaaaggaccg
     2761 gcaggaaaag gagctttctg tcccagtaaa attcctggca gaagtttctc tttgttcaga
     2821 taacggtcgc cctggaaaca tacatattct ttttggttga tcgcctcggt tatgcggaaa
     2881 acgtgtgtca ggttgtcttc attgacaggg ataatcttaa actccttgtc ctgaccgttt
     2941 ttctccagga tctctttgat tctacgatgt tcggcatcgt acatcacgat attgattttc
     3001 tttccgtaat catcaaagaa aggaacgcct atttcccagt ttcccacatg ggcgccaatc
     3061 ataatcactc cctgttcact gttcagcagt tgcagaaact ccggataccg ctcgaatttg
     3121 aactgatatt gatttacttt tccattaccg atggctacct tgtcaatcag gatttgtcct
     3181 aatcggtaat agttgagtag taacattttc aaagaatgta tcctattgta tttcagaatg
     3241 ttacgggcgt aaaaccaggt gcttttggtt gctttcggag caaacggtat gaagtagagc
     3301 actaccaggc ttagaaaaag ataagcggca gtgatgccca gatacttaat caggtaaata
     3361 aagaataagt atccgaacgt tcctccccgg gttttgcctt tccacgtcga catatttact
     3421 tggcttcctg catacgggtg ataacgagat cgtagaagtc ctggaaggtt ttgatacctg
     3481 caaagtcttg tccggttaca ttgaaaccga aattcttttc taccagtacc accatgtcga
     3541 ccaagtcgag actgtccagt tcaagagttt ccattaacgg cgcatccggc tggatgacgt
     3601 cgatgtctac ttcaaactct tctgccagag ttgttcttat tttctcaatg atttcttcat
     3661 ttgtcatata tctgttttct ttagtaattt attctttgat ttggcgtata atcagggtgg
     3721 aattggttcc tccgaatcca aacgaattgg aaaggaacgt gtcaaattcc agatttaccc
     3781 gttgggtagg tatattcaac tgtgcggaag cctcatctgg ttcctcgaaa ttgaggttgg
     3841 gagcgatgaa accgttgttc atcatgaggg tggagtaaat cacttcactg gcacctgcca
     3901 tccacatttc atgtccggtc atagacttcg tggaagtgac atacgggtga tgtccttcaa
     3961 atacttccgc aatggctttc gcttcgttca ggtcgcctac cggagtggaa gtggcgtgtg
     4021 cattgatata actgatttgt tcgagtgcaa tacccgcatc tttgatggcc atctgaagag
     4081 aacgtttcgg accgtccaca ttcggtacgg agatatgatc tccattggaa gagaaaccgt
     4141 aaccgataac ttcggccaaa atgggagctc ccctttttac tgccgattca tagctctcta
     4201 ataccagact ggcggctcct ccactcggaa tcagtccgtc acgtcgttta tcaaaaggtt
     4261 tggaggcttt ctcgggctct gcttcctggg tggaaaatgc gcttagcccg tcgaaactgc
     4321 cgaccgcata aggatttact tcttgtgcac caccgcaaag aatacaatcc tgcaatcctg
     4381 atttaatgag cagataaccc atgccaatag catgagaacc acttgcgcag gctccggcaa
     4441 tggtgaagtt aactcctcta agcttgaaga taaccgacag gttcattgtc acggtagaat
     4501 tcatcgactg gaaaatagaa ccggaaccta ccaacgctgt atttttcttt tcacgaatga
     4561 tgtccactgc gttgataaca ggggcggcac tactatcatt gccatacaag atacccactt
     4621 cattagcttc gagaaaagcc tcgtcaatac cggcgttgcg gaaagcctcc aaagtagcga
     4681 gataagcata ttctccctgt tccggcaggc agagacgttt acgacgatct aatagtttct
     4741 tcaagtcggg acgttccaat atgcccgtta atgcagaaaa atagcccagc tctttccgta
     4801 ccggatctat gccaatcccc gatttcccat tgtatagtga gtcttttact tcatccaggt
     4861 tcttgccgat gcaagagtaa attcccattc ccgtgataac aactcttttc attattttgt
     4921 ctattctatg cttttgtttt aagtatatag tcctccgttg atggaaatca cctctcctgt
     4981 gatataggat gaggccggag atgccagaaa accgacgaga tcggcaacct cttccacagt
     5041 accgaaacgt cctgcaggaa tgtgtttttt ccattcgttc tcatcaatcc cttccgtcat
     5101 atccgtgcgg ataaatcctg gggctacagc gttgactgtt acctttttct tggcgacttc
     5161 ttgtgccagt gctttggtag cggctattac gccacctttg gctgcggaat agttagcttg
     5221 tccgggcatt ccctgaatac ctgacaagga tacgatattg acaatacgtc cataacgctt
     5281 gaccagcata ttcttcaata aaggctgtgt cacataaaag aatccgttca gactgatatc
     5341 gagcactttg ttccattctt ctcctgtcat ccagagcatc aggttgtctt tacggatgcc
     5401 cgcattgttg atcagtactt cgatgtattc gtcaggatgt tgtgacgccc agttgttcaa
     5461 ggcaagggca atagcggcag ggtctgtcac atcgaacttc atgatttctc cgttacttcc
     5521 tttttcctgc actaactgca acgttttttc tgcttctgcg tcgttactct gataattaat
     5581 cagtataaag tagcccattt ccgccagttt gcaactgaca gcacggccga tacctcgact
     5641 tcctccggtt actaatgcgt atttcatttt atttattttc ttttttgaga tagttcatca
     5701 ttctttctat ctctttatat ttaggtgtgt cattggtaaa tacagggaag aagctacgta
     5761 tctcttcata cacctgccgg cttttgggac ttagacgatc ctgtattttc aggtagtcga
     5821 tggcttgtgc cattcccata aattgtatag ccatcacctg ataagaattc tcaatgactg
     5881 tttttgctaa tagagccgag ttggttccca tgctgacaat atcctgatta tcgttgttgt
     5941 taggaatact gtgcacatac atcggattcg acaatgtctg acattcggcg gtagtggacg
     6001 ttgctgtgaa ttgcgaagcc tgcaaaccgt agttcaatcc aagcactccc aagtttacaa
     6061 aaggaggcag gatgccattg atacggtcgt ggaacagata attgatctgt ctttcgcaaa
     6121 gcatggtcag tttggtcacg gcgattttca gtttatccat ttcgaaagag atgtaatctc
     6181 cgtggaagtt accgccatga taaatatttt gtgtgtccgg atcgacaatc ggattgtcgc
     6241 aggcggaatt tatttcgtta atcaatactt cttccgcatt cttcagctca tcatagatgg
     6301 gaccgaggat ttgcggaaca catcgcaagg aataataggg ctgtactttg tgctcgaaga
     6361 ttttttcttt gtgcacttgg ttgtatagct cattctctct ttgaagtaca catttgctgc
     6421 ccgataccca ttctctcatc atagcggcta tctcttgttg ccctttgtga tgcttggcct
     6481 cgtttaatgc ctgtgccatg aaatcatcat aagaggcggc aatctcattc atcatgacag
     6541 aagcggctac cgaccaacgg agcagctttt tggcataaat cagattgacg ataccgattc
     6601 ctgtcatcac agaagtaccg tttgtgacgg ataatccttc gcggatgcgc attgaaaaag
     6661 gttgcagacc gttttcctca agcacagtag cggcatcacg caatttcccc tgataaaaaa
     6721 cttccccttc tcctattaat gtcagggcaa tatgggccag ttgcacgaga tcgccgctgg
     6781 cacctacact tccatgttcg ggtatgaacg gataaattcc acggttgata aattcacaga
     6841 gaagagatac cagctccatg tgtactcctg atttcccctg tagaaaagtg tacaggcggg
     6901 caatcatagc tgcttttaca taaagttcgg gaagtggttt gccggcaccg gtggaatggc
     6961 ttcgaatgat attgtactga agctcgatca gtgactgatc ttctatccgg tattgtgcca
     7021 ttgggccgaa ccccgtattg ataccataaa taatcttatc gctggaaaaa gattgtagga
     7081 aatcgaagct ttcctctact tttcggatgc attctttaga gagttccagc ttctcattat
     7141 caaacaatac tttataaagg gtatctaaat ttatactttt gtcagctatc attttctgta
     7201 ctagatattt tatgccttat taattaaggt acaaaaatag gcaatttctg ttatatagcg
     7261 gacatgaatc agaataaaac tttttccgga gaattggttt tgcttgtttt gtttctcatt
     7321 tgcgaggggt tttcttttcc gatgctaagg ggtgatttca tccgtgggga aggtgtcctt
     7381 ctccggtttt gaagggaaac ttttatcaat gggaggaaat ctatttatgc ttttagcaag
     7441 tcccgttctt catatttgca gatcgcttct atccattctt ctgtcagtgg catggattca
     7501 tgtctttcaa gatcgaaagt aaccataaca gacttacaga tacattttac ttcattcgtt
     7561 tctgtgtcga taacccgctg gatcaggtga aagcttttgg tgcctatctt agaaacagca
     7621 gtctgtacgg cgatatgatc ggatgcgaat atctgtttga cgaaatccgc ttcgatatgg
     7681 acaacgacaa tcccgatctt ttcccaatct actccggggc atactgaagc gaagtattca
     7741 gtctttccta agtcgtaaaa ggagaagtaa actgtgttgt tgacgtgacc aaatttgtct
     7801 acatcattga atcgcaattg gataggtaat gtgtgatgaa atacgatttc ttccattgtt
     7861 ttctcttaaa cgttttaaat tcgacacaaa aatagcactt ttgctttctt gcttgaaatt
     7921 gaggcaaaga tagagatttc taatgattct gctttcggag ataaggaaga tttttgttaa
     7981 taatcgttta aaacgaagtt ttgggatgtt tgtcctgtta gggaaacacg cttgtataat
     8041 gtaatagtta aattattgtc tgccaatagt tgattttaaa gggtaattta aaaacgtcag
     8101 gatagatttc actaaatgga ataaatgtgt tatttttgcg tcttgttctt aacggaaatt
     8161 aatcaagaaa tgatagaaga tattaaaaaa gcctgtcagg tgatgaatga aggaggagtg
     8221 atcctttatc ccactgatac cgtatggggt ataggctgtg acgcgactaa tgaggaggct
     8281 gtacgccggg tatatgagat caagaaacgt gctgatagca aagctatgtt ggtgttggtg
     8341 gattctccgg ttaaagtgga tttttatgta caggatgtac ctgatgtagc atgggatttg
     8401 attgaagttg ccgacaagcc gttgacgatt atttattccg gggcacgtaa tttagcacct
     8461 aatttgctgg ccgaagatgg tagtgtaggg attcgtgtga cgaatgaaga tttttccaga
     8521 agactctgtc agcagttccg taaagcaatt gtttctactt cggctaatgt cagcgggcag
     8581 ccgggtgctg ctaattttag tgaaatcagt gatgaaatca aatcggcggt agattatatc
     8641 gttggctttc gtcaggatga tatgaataag ccgaaaccct caagtattat taagttggaa
     8701 aaaggtggag tgataaagat aattcgcgaa taaatgaaag gagaaaaact tagtttattg
     8761 cagcgttgta tcaaatggcg ggaagcgaac ataaaggaga agcaatttat cctgatatta
     8821 agtttcttgg tcggaatctt cactgcgttt gctgcgttaa tattgaaatt ctttatccat
     8881 cagatacaga atttcctgac taataatttc aatgcaacag aagctaacta cctgtatttg
     8941 gtatatccgg tagtcggtat tttccttgca ggttggtttg tgcgtaatat tgtaaaggat
     9001 gacatcagtc atggggtcac caagatttta tatgccatct cccgtaggca gggacgtatc
     9061 aagcgacaca atatctggtc gtctactatc gccagtgcca taaccatcgg atttggtgga
     9121 tcggtcggag cagaggcacc aattgtactg acaggttcgg caatcggttc caatctcggg
     9181 agcgtgttta agatggagca tcgcacgttg atgctgctcg taggttgtgg tgcggcaggt
     9241 gccattgccg gtatttttaa agctccgatt gcgggactgg tatttacctt ggaagtgctg
     9301 atgattgact taaccatgtc ttctttgctt cccctgctga tttctgccgt gacagcagca
     9361 actgtttcgt acatagtcac tggtacggag gctatgttta agttccacct cgatcaggca
     9421 ttcgaactgg agcgtattcc tttcgttatc ttgctgggaa ttttttgcgg actgatttcg
     9481 ttgtacttca cacgtgccat gaattcggta gaaggtgtat ttggcaaact caataaccct
     9541 tacaagaaac tggcttttgg tggtgtgatg ttgagtgtat tgattttcct tttcccgcct
     9601 ctttatggtg aaggatatga tacgattaat cttttgttga atggaacgtc tgccgaagag
     9661 tgggatacgg tcatgaacaa ctctatgttt tatggctatg gcaatttgtt gctggtttat
     9721 ctgatgctga ttatcttgtt gaaagtattt gcttccagtg caacaaacgg tggcggtggt
     9781 tgtggtggta tctttgctcc ttcgctttat ttgggatgta ttgccggttt tgttttctct
     9841 cattttagca atgactttgc tttctccgct tatttgccgg agaagaattt cgcattgatg
     9901 ggaatggcgg gagtaatgag tggtgtcatg catgctccat tgacaggggt gttcctgata
     9961 gccgagctga caggtggata tgatttattt cttccgttga tgattgtatc tgtaagttca
    10021 tatctgacaa ttattgcttt tgaacctcat agtatctatt cgatgcgttt ggctaagaag
    10081 ggacagttgc tgacacatca taaggataaa gctgtgttga cgctgatgaa aatggaaaac
    10141 gtggtggaga aagatttcgt tgtcgtacac ccggaaatgg acttgggcga actggtgaaa
    10201 gcaattgctg cttctcatcg aaatgtcttt ccggtgacag ataagaaaac aggtgaattg
    10261 ttgggaattg tattgctcga cgatattcgc aacatcatgt tccggcaaga actttatcat
    10321 cgtttcactg ttaataaatt gatgatatct gctcctgcca aaatcttcga tacggatgga
    10381 atggagcagg ttatgcaaac atttgacgat acgaaagcct ggaatcttcc ggttgtagat
    10441 gaggaaggcc gctatcaggg atttgtctct aaatcaaaga tatttaattc gtatcggcaa
    10501 gtgctggtac atttttctga agactaatcc gtgcctaagt aatgataaca gatttaaaat
    10561 atgaagaaag aagatttaag aatagtatat atggggactc ccgattttgc ggtagaggcc
    10621 ctgcgccaat tggtagaagg cggttataat gtagtgggtg tgattacaat gcccgataaa
    10681 cctgccggac gcggacataa gattcaatat tctcctgtca aacaatatgc gctcgaacag
    10741 aatttaccgt tgcttcaacc ggaaaagttg aaagatgaag cttttgtgga agcgttgtgt
    10801 gagtggaaag cggatttgca gattgtagtt gctttccgta tgttgccgga agtggtatgg
    10861 aatatgccgc gactgggtac atttaatctt catgcttctt tacttcctca atatcgtgga
    10921 gctgctccta tcaactgggc ggttatcaac ggtgatacgg aaaccgggat tacgactttc
    10981 tttttgaagc atgagataga taccggagag gtcattcaac aggtacgtgt gcctattgca
    11041 gatacggata atgtagaagt ggtacatgat aaattgatga tgttgggagg aaaactggtt
    11101 cttgaaacag tagatgcgat actgaatgga acggtcaaac caattcctca agaagaaatg
    11161 gcagttgtcg gtgaactccg tcctgctccg aagatattta aagaaacttg ccggattgac
    11221 tggaaccagc cggtgaagaa gatttacgat tttatccgtg gactatcacc ttaccccgct
    11281 gcctggagtg aactgattgc ttccgaaaaa gcagaaagtg tggtcgtgaa aatatttgaa
    11341 agtgagaaag tttatgaatc acatcaattg gctgccggaa caatcgtgac tgatggcaag
    11401 aaatttatga aagtagctgt atcggatggc tttgtatcta ttctttcttt acaattaccc
    11461 ggtaagaaac gactgaaaac agatgagtta cttcgtggtt atcacctgga agatgggtgt
    11521 aagatgaagt gatctgacaa taagatagaa taaaaaccgt cccgaacacg agacaattag
    11581 aacctaaaat aaaagaatta tgaaaccgat tatcgctcct tctattcttt ctgccgattt
    11641 tggatatttg gcaaaggata ttgaaatggt aaaccgcagt gaagcggagt gggtacatat
    11701 tgatattatg gacggagtat ttgttccgaa tatttcattt ggctttccgg tactgaaata
    11761 tgtagcgaag ttaagtaaga agccgttgga tgtgcatttg atgattgtga atccggagaa
    11821 attcattccg gaagtaaaag cattgggtgc tcatacgatg aatgtgcatt atgaagcttg
    11881 tccacatctg catcgggtga ttcaacaaat cagagaagcc gggatgcagc ctgctgtaac
    11941 gatcaatcct gctactcctg tagctctttt acaagatatt atccgggacg tgtatatggt
    12001 gcttatcatg agcgtgaatc caggatttgg cgggcagaag tttatcgaac attcggtaga
    12061 aaaagttcgt gaactgcgtg ccctgattga acggacaggt tcgaaagccc tgattgaagt
    12121 agacggtggc gtgaacctgg aaacaggagc ccgtctggtt gaggcgggag ccgatgcgct
    12181 ggtggctgga aatgctgtct ttggtgcaca ggatccggta gaaatgattc gtcagttgca
    12241 cgaactgtaa ctaatctatt gaattccttt tatatccatc gatatccatt tatacgcctg
    12301 cttatccctt ggatagcagg cattttttgt ggagatcatt tttttgaccg ttcatgggat
    12361 cccctttgtg gtattctctt ctttggcttt tttgctgtat tgtcttttgc tctttatttt
    12421 ctgaaacgct attcgctgcg atggtgtttt gggatagcta tctccgctct ttgttttacg
    12481 ggaggatggc ttgggatgac tggacaattg caacaggctg tctgctcttt tccgaaagaa
    12541 gaaactgtgt accgggtttt gataacggat gtgcctcaac ctaaagaaca tacttacctc
    12601 tgtcaggcat tattgaaaga acgtcgtgat actgcgggca tatatccgat aggacatact
    12661 gcggttcttt atctacagca agattcgtct gcctcccgtt tgaagagtgg agatgaactg
    12721 ctgatttctg ctcgcatttc tcctcctctc aacaatcgaa actttgatga atttgattat
    12781 gcccgcttcc tgatgcggaa agatattagc ggaacaggat atgttgcatc cgggaaatgg
    12841 acaatcttat cttcaagcaa accaccctta tcttctgcta atccatccat ctctttacga
    12901 caagacggaa tgaataactt tgacctcaaa agtgtagcca gctcttgtag aagaaacgtg
    12961 gtttcacttt atcaggaact gggattcaac ggggatgaac tggcagtact ttcagcacta
    13021 acaataggag ataagacaga attaagtgat tcggttcgtg aaagttattc ggtagcaggt
    13081 gcaagccata ttcttgctct atccggtttg catatcggac ttttatatac aatgatcttt
    13141 ttcattctga aacctattgc ccgaagagga aatataggta gatgtgtgcg ttctgttttt
    13201 cttcttgtct tattgtggac ctttgctttt tttacagggc tttctccgtc ggtagtacgt
    13261 tcggtcagta tgttttcgat tttagctatg gcggatatga ctggtcgtga acctttatct
    13321 ttaaatacat tggcggtagc tgcgtggttg atgttattct gcaatcctgc atggttgttc
    13381 gatgttggtt ttcaactctc tttccttgct gttgcttcta tcttgcttat ccaaaagccg
    13441 atctaccatt tgattaccgt gaaaagtaga ataggaaagt atgtttgggg gctgatgagt
    13501 atatctgttg ccgcacaaat aggaacagct ccgcttgttc tgttttattt ctctcgattc
    13561 tccgtgcatt ttctgttgac gaatttagtt gttatacctt tgattacaat tatcttatat
    13621 gctgctgtcg taatgcttct tctggctcct ttctcctggc ttcagatagg agtggccgga
    13681 ggtgttaaga agctgttgga aggacttaat ttctttgtcc gatgggtaga gcagcttcct
    13741 tgcgcttcta tagatggaat ttggctttat cagtcagaag tgctaggtat ctatattgtc
    13801 atcgctctgc taacctatta tttcatgaat cgccgatacc ggaatctgca aatctgtctt
    13861 ttttctatct tgttgatggg gacttatcat gcaacgctgt attggcagga tcgtcctcaa
    13921 acgagtttag tcttttacaa tgtgcgtggt tgtccggcag tacattgcat aaaaagtgac
    13981 gggcaatcct ggataaacta tatggatact ctctccaatg aaaaacgtct gaaacacatg
    14041 acagctaact attggaagcg tcatcacctt cttcctcccc aagaaataac ggctgattgc
    14101 cggcacgctg aacttaaccg tcaacagcag attatatcct atcatggttg tcgtgtatgt
    14161 gtcataaacg ataaccgttg gcgaaacaaa tccaccgttt ctccgttata tattcagtat
    14221 ctttacttat gcaaaggata tgacggtcat ctggaagaac ttgcccaggt cttttctttc
    14281 tcttacgtca tattggacgc gtccctctcg gaataccgca aacacctcct tgaaagcgaa
    14341 tgcaagaaat ccggtctgcg atttatctct ttggccgacg aaggttctgt ccgctttttg
    14401 ctctaagtac aaagatttat cgtacatttg caccttgata aagtttaaga gtatgttgac
    14461 gaaagtaatt gaacaagcca aaatagacca ttttaccaaa tggtttgaac gagctgacaa
    14521 aatagtaatt gtatcccatg tttctcctga cggcgacgct attggttcat cattgggatt
    14581 gtatcatttc ctggattcac aggaaaaaac agtaaacgta attgtgccga atgcctttcc
    14641 cgatttcctg cgatggatgc cgggcagtaa ggatattctt ttgtatgacc gttacaaaga
    14701 ttttgccgat aagttgatag ccgaagctga cgtaatctgt tgtctcgact tcaatgcatt
    14761 gaagcgtatt gacgatatgg cagatgctgt ggctgcatct cctgcacgta aaatcatgat
    14821 cgatcatcac ctgtatcccg aagatttctg taagattgta atgtcctatc ctaagatttc
    14881 ttctacttcc gaattgatat tccggctgat ttgtcgtatg ggatatttca gtgatatcac
    14941 gaaggaaggt gcagaatgta tctacacagg catgatgaca gatacaggag gattcactta
    15001 taattcgaat aaccgggaaa tttattttat cattagcgaa ctactttcca aaggaatcga
    15061 taaggatgat atttaccgta aggtgtacaa tacctattcc gagagccgtt tgcgtttgat
    15121 gggctatgta ttgtcgaaca tgactgttta tccggattgt aattcggcat taatcacatt
    15181 gacaaaagcc gagcaaagta agtttaacta tataaaaggt gatagcgaag gcttcgtaaa
    15241 catccccctt tccatcaaga atgtttgttt ctcctgcttc ttgcgggaag atacagagaa
    15301 gccgatgatt aaaatctccc ttcgttcggt aggaaccttt ccatgtaatc agttagccgc
    15361 tgaatttttc aacggtggcg gacatttgaa cgcttcgggc ggtgagtttt tcggaacgat
    15421 ggaagaggca aaagcggtct ttgagaaagc gcttgagaag tataaacctt tgttaacagc
    15481 aaaaagctaa agatggaagg ttaaaagtga atatggaaag gttaaaagat acgaactttc
    15541 aacttccccc tttcaacttt taatgatttt gagatacatt tgtgcggaat atagctaaat
    15601 aacagataat gaagaaactt gtatttttat ttctctcttt gttaaccgcc ggaagtctgt
    15661 tccaggcatg cgacaattcg aagacttatg cagaaatgct ggaagacgag aaaaatgcgg
    15721 tgaataagtt catcaaagat aatgatattc gtgtcatttc actggaagag ttcgaaagag
    15781 acactgttac ggcttcaaaa gaagctgggg atggatatga cgaatatgtt gctttttcca
    15841 acggcgtata tatgcagatc gtagatcgtg gcgggaaaga ggaaggtgag aatggggttg
    15901 agtttattaa tgaagtagac acttttgcta ataataatgt catttgtact cgttatgtag
    15961 aaaaggatat gatgacagga gaggttactt gtttcaatgt accattagaa gaatggatgg
    16021 atgctcctga ttattataag tttccattaa cattccgtta tgtacaaaac gcgtctactg
    16081 tttatggaat cgttttatcc ggtagtttgg aatatgattt attatgggtt aatcaaggtt
    16141 atggaactgc aattccatcc ggctggttga ttgccttacc ttatttgcgt aataatgcac
    16201 atgtacgctt gattgtacct tctaagatgg ggcatacaac tgcacaacaa tatgtcaatc
    16261 cttatttcta tgatatctgg aagtttgaga aagcaaaaag ctaaagcact aacattagat
    16321 aaatctttta gttaaaaacc tatgactcta atcaaatcta tctctggaat ccgcggaacc
    16381 atcggcggag gagcgggaga aggactgaac ccgcttgaca ttgtaaaatt cacctcggct
    16441 tatgctactt taattcgtaa gacctgcaaa gcgaagagca acaagattgt tgtgggacgc
    16501 gatgcccgca tctcgggtga aatggtaaaa aacgtagtag tcggcacatt aatgggaatg
    16561 ggctgggatg tagtagatat tgatcttgct tctactccga ccacagaact tgctgtgaca
    16621 atggaaggcg cttgtggcgg tatcatcctg acagcttctc ataaccctaa gcagtggaac
    16681 gcactgaagt tactgaatga acatggcgaa tttctgaatg cagctgaagg caacgaagtg
    16741 cttcgtattg ctgaagcaga agaatttgac tatgctgacg tagatcactt gggctcttac
    16801 cgcaaagacc tgacttataa tcagaaacat atcgacagtg tattggctct tgacctggta
    16861 gatgtagaag ctatcaaaaa agcagatttc cgtgtagcca ttgactgtgt aaactcggta
    16921 ggcggtatca ttcttcccga acttcttgaa cgtttggggg tgaaacatgt agaaaaactc
    16981 tactgtgaac ctaccggaaa cttccagcac aaccccgaac cgcttgaaaa gaacctcggt
    17041 gacatcatga acttaatgaa aggtggaaag gccgatgtag cttttgttgt agaccccgac
    17101 gttgaccgtc tggcaatgat ctgcgagaat ggcgtaatgt acggtgaaga atatacactg
    17161 gttactgttg ccgactatgt actgaaacat acccccggta acactgtttc taatttgagc
    17221 tctacccgtg ctttgcgtga tgtaactcgc aagtatggaa tggaatacag cgcttctgcc
    17281 gtaggcgaag taaatgttgt aacgaagatg aaagcaacca atgccgttat cggcggtgag
    17341 ggaaatggtg gagtaattta tcctgccagt cactacggac gtgatgcatt ggtaggcatc
    17401 gcattattcc ttagccatct ggctcacgaa ggaaagaagg ttagcgagct ccgtgctact
    17461 tatcctcctt acttcattgc taaaaaccgt gtagacctga ctccggaaat cgatgtagat
    17521 gctatccttg ccaaagtaaa ggaaatctat aagaacgaag aaatcaatga tatcgatggt
    17581 gtgaaaatag actttgccga caaatgggta catttgcgca agagtaatac agagccgatc
    17641 atccgtgtgt atagtgaagc ttctaccatg gaagctgccg aagaaatcgg tcagaagata
    17701 atggatgtga ttaatgaatt agcaaaataa tatcctgtaa aataggattt tatttataac
    17761 atttgagtct cgtatatcat aaagataact gaataagttg tctcattgat atacgagact
    17821 ttttattagg atgatatcca ctgaatgata atagttactc ttctccttga gtattaacaa
    17881 taaagtttct tttgattaag tctaaacttc ctttcgtcta atagtaaact tctcttttgt
    17941 tatttacaaa cttaaaatga aagcttcatt tttataaatg caagctttgt ttttaaaaac
    18001 ggaacctttg tttttataaa tgaagcttgc atttatagat tggaagggat gaaaagcaac
    18061 tttactgtta ataaaaagaa agtttggact taatcaagag caacttttct attaatagat
    18121 tacatgagaa gtaagcagtg ttgagagaga agtaatcaac aaagcttact tctctgcgtc
    18181 gttagcatag atacaccaca agaatatcaa ttggtataca actttatagg tcttatatca
    18241 atgataaaca catggcttaa atatgcatat tgataaacgt acggcatgaa aataaaactg
    18301 attgcattat ttataatgat gagatcattg aaaaatggaa gaggcagact cttagattgt
    18361 gtgaacttag tagtgaagta attgttgaaa aatagaggta cttgataaaa tagagttgca
    18421 ttttccgtat aaaaacgtat ctttgtgtaa agagaatcaa agacatcgat tattaatggc
    18481 tattttcttt cgcactgcga aacaaaatat ataagcgatt gcctgatatt taatagatga
    18541 tattaatgat taacacaatg aaaatgcgct tgatttttcc ttttgttcta ttgatttatt
    18601 cattgatctg tcaggcagat ggtggtaaag attcatatat cttccggaaa gtagattatc
    18661 agcaaggatt atctaatagc gctgtgcttt gtctttttca agacaataca gggttgatgt
    18721 ggttcggtac ttacgatgga gtcaattgtt atgacggcag aagcatggaa gttttccgtt
    18781 ccgatttttc agctcccaag gctttgagta acaacgtaat ccattctatt cagcaggcgg
    18841 ataataattg tttgtggatt tctactcatt tggggattaa tcgtctttca cagaattcac
    18901 ggcaagttgt cggatattat gactttacag atgattatta tctacattcc aattctaaag
    18961 gaaacacatg ggtggtgagt catggtggaa ttttctacta taatacatct tataaacgat
    19021 ttgtacagat taagaatctg aaagtacccg tagaggatat ggataaacgg gcgttcgtaa
    19081 cggatgatgg tgttttgtgg attttcaccc aacaaacagg ggagctgtta caggtttcgc
    19141 aggatgcttt tgattgtgac acattatcaa ttcattcaac tgtttcatct actaattttc
    19201 atgcgaaacc tattgaagat gtcttttatc agaatggcgt tctctgtttt atcgatagtg
    19261 agcatgatct ttatgtttat gatatttccc gacaatctaa aatttatatt cgtaaccttt
    19321 cttcattagt gcagaagaat ggaactattg caggaatagc ccttttctat gaagatatta
    19381 ttattggttt tcgaacgaat gggttagtcc gtctccgtac ttcacaaaaa tataaagaag
    19441 aagtggtcga ccggaatgta cgtatatata gtatttatcg agatcctcat cagaatgtct
    19501 tatgggttgc ttcggacgga caaggaacga ttatgtatgc taagaaatat tctattgcca
    19561 ccaatttgat gctcaatcaa ctgtcatcta acttaagcag gcaggtacgt tctgttatga
    19621 cagacaatag tggtgggcta tggttcggga cgaaaggtga tggactgctg catataccgg
    19681 attatcgtga gaatgaggag gcttctgccg ttacagttta ctctcctgaa ggaaagcaaa
    19741 atgttgtgtc ttatatacga tggaataaag aatttcccgt ttataaattg gttcaaagcc
    19801 gttatatgga tggcttttgg ataggatctg gagatccggg actattttac tattcttttg
    19861 aagacaaagc tttgcattct gtggagaatc tgccggcaca acccaccgag atacatggca
    19921 tttatgagga aaatgatagt gtactttatg tggtgacagc cggttccggt tttcataaat
    19981 taatacttga gaagcaggca ggtaccattc gtttcaagtc gcagaaaagt tatcattttt
    20041 ttcacggtca gcgagaaatt acgatgttct atccaatgtt gcccgaaggg gattctattt
    20101 tgtggcttgg cagtcgggag aaaggactcg tacggtttga taagcggact gaagaatata
    20161 aagtgatttc tttgaaagaa atgcttcata agtcggtaga cgatgtgctc agcctgtatc
    20221 ggaccaaaga agggttgtta tatgtaggga caacatcagg attggtatgt ctgaattcta
    20281 atggaaaaca gatgaaagct acctatatcg gacgggagca aggtttgctc aatgatatga
    20341 ttcatggtgt acttgaagat gagaacggac tcttatggct tggtacgaat cgggggctga
    20401 ttaaatacaa tccgataaat ggctcatcac atgcctactt ttacagtgca ggtgttcaaa
    20461 tcggtgagtt tagcgatgat gcttattaca tgtgtccata tacacaggag ctttttttcg
    20521 gtgggattga cgggttactt tatctggata aagaggtgca ggctgctccg gaattttatc
    20581 cggatatttt gttacgtaag ttgactgttg gacatacgca agtggttcag ggggatggag
    20641 attactatac agacgatggt aaggcattac agttgaaggg gacggaggtt tcatttgcac
    20701 tttcttttgt tgttccggat tttttatcag gagaagatat agaatattct taccagttgg
    20761 aaggatatga taaggattgg acctctttta gtagtattaa tgaagcctca tatacaggag
    20821 tgccggcagg tgattatatc tttaaggtac gctataagag ggatgtattt gatacggaat
    20881 atcggcattt ttctattccg gtatatatcc tttctccctg gtatcgatcg gtggcggctt
    20941 attttgttta tttggtcatt ttcttgttgc tgttagggta cgtgatatat ttactacgta
    21001 aaaactatct tcaggaacgg atgatgaaaa cactgatggg gacagaaagt tgccggaaat
    21061 ccgagactgt atatacaaac cgtaggatgc ttgaagattt tactcttatt tataattatt
    21121 gtgaccaatt gcgtgcagag aatctttctt atgagcaatg tcttgagaaa gtgtcactga
    21181 tacgcgaaac tgtgatgaac gcacttctta atcctgacgc tctgtttttg gaagaactta
    21241 aacaattctt tccggatcgg tttattgttt ctgcacgtat gagtatacag ggagtttctc
    21301 aagaggtgtt acgtacgttg gaagaacaag ggattgatca ttcttctata tcgtcaatga
    21361 ttccggaaca cttaacattt ccagtttaca agaatgcatt atacagtatt ctttattgct
    21421 gctatctccg gattactgaa atgaaaggta ctcatggcgt aatagtagaa atgtcagaac
    21481 aggatggtaa gatgcagcta catttttctt ctaaagatgc tactgcgaaa gcgttgtatg
    21541 aatatctttc agataaagct tcttcagtga cggagaaaga ttccgatcat gtgtttgctg
    21601 tgcatttact tttaggtttt gtacggtcgg ctttggaacg tattcatgcc gttcttcgtt
    21661 atgatgatga tgagagtggt agtcggttga cgattatctt tgaaccggca gtcttgacag
    21721 tggcaggtga acaagggaaa aaaactgtgc ttttgttgga agacagagat gaaatgactt
    21781 ggttgattag taatttcctg gctgatgaat acgtggttca tcaagtaaag agtgtgcagc
    21841 ttgcttttga cgaaattcgt cggtcggctc cggctctatt attagtggat atgacaatgt
    21901 atgccaatgc tgaaagtact tttatggagt atgttagccg gaatcgtact ctgctttcaa
    21961 agacagcttt tattccattg ttaacctgga aagttggttc ggccattcag cgggaactga
    22021 tcttgtggtc tgattcttat attgtacttc cttatgatat attattcttg cgggaagttg
    22081 tccataatgc tatttatgga aagcgggaag cgaagcagat atatatggag gaactgggag
    22141 atttggcggg acagattgtc tgtacaacta ccgaacaagc tgattttatt cgcaaattgt
    22201 taaaggtgat tgaagaaaac ctggacaagg aagaactggg ctcaacgttg atcgctgatc
    22261 gtatggcaat gagttcccgt cagttctatc gtaaattcaa ggaaatctcc aatactgctc
    22321 ccggtgattt aataaagagt taccgtatgg aaaaggcagc ccgcctgtta cttgatgaag
    22381 aactttctat tcaagatgtt attatggagg tcggtatttc cagccggtct tatttttata
    22441 aagagtttac ccgtcggttc gggatgacac cgaaagatta tcgggaacag cgaaaggtat
    22501 gctgattgtc aggttaaatt ctttcgtata ggtgattagt tgggaaacat tattatttat
    22561 ttgtttgtca caaccttgtg ctctaaatcc cttttgttga ttttattatg ttgattatta
    22621 gtgtgttaat ctgtgctcta atttaccatt ctgtgcttta aatatgtgtc tttattttgc
    22681 cgtttttttg gcaaggtaga gcattggact tttattcgaa tagcctttat ttgcaacaat
    22741 ctttttaaag ggaattaacc ttattactaa tcaaatttaa aggaattatg aatgaaaaac
    22801 taaagtatct taccttattt gtaataggta tgatgttgag tttgggcatg aatgctcaat
    22861 ctgtaaaatc aatctccggt acggtaaccg atgatcaggg agaggcggtt atcagtggta
    22921 cggtgaaagt taaaaacggt agtacaggaa caatcactga cattaacggt aaatacactc
    22981 tctctgttcc ttccaatgcc accttggtgt tttcgtatat tggttatatc acacaagaat
    23041 ttaaagtctc ggaattaaag agtaatgttc tgaacgtagt tctgcaatcg gatacgaaag
    23101 cactggacga agtagtcgtt gtaggttatg gtaccatgcg caaatcagac ttgacgggtt
    23161 ccatttccac agccaaaggt aaagacatgc tgaaagcaca atcattcaat gcgcttgacg
    23221 gattgaaggg taaagtggcc ggtgtgaata tcttctctaa taccggtcag ccgggtggag
    23281 aatcacgtgt catcattcgt ggtatttcta ctatcaacgc atcggcatca ccgctgtacg
    23341 tagtagatgg agtggtgatg tcaaacttcg aattgcttaa tccgaatgat atcgaatcta
    23401 tcgaagtatt gaaagatgct tcctctgctg ccatctatgg tgcccgtggt gcgaatggtg
    23461 ttatcatggt gactaccaag cgcggtaatg caggaaaagg agtccatgtt tcctatgatg
    23521 gttcattgtc tatcggtaag atggctagaa aaatagatgt aatggatgct aacgaatgga
    23581 tgtctacctt caagcaggga ttggaaaatg ccaacgaatt tcaaggcaag aacttcacaa
    23641 ctgatctgtc acagatattc acagacgaac gtttgttcaa tgcagacggt tctccgaaat
    23701 ataataccaa ctggcaggat gaagcatccc gcactgccat ctctcataac catcagatca
    23761 gtatccaacg tacaggagaa ggatcttcta tcggagcatt catcaattat accgatcaac
    23821 agggtatttt gttgaattcc tacttcaaac gtatcaatgc aaaattggcg tatgatgaca
    23881 aaccgactga ttggctgtct acttccgtta atttattagt aaatcatact tggggtaata
    23941 gaacttctga taacccttac ggacaaggcg cattgcgtac aatgatcgaa cagttgcctt
    24001 tcttaccggt taagctggat ggtgaatata cgcagacgaa cattattaat acaagctcta
    24061 ttctcaataa tcagactgat cctaatagcg gaaaacaagg attcagcccg gaaggtgtag
    24121 gtaatcccgt tgagttgctc gaacggatgc aggctatgca atatcgtacg cagatttttg
    24181 gtaatgctgc tttgactttc catctcatga aaggattgga tttgaagacc cagttcggta
    24241 tcgactacca caataatcgt gatgctaact atacgccgtt cactccgcgt ccgatgatta
    24301 atcaaagttc cgagggagca gcttctgcaa ataactccaa ctctttgtat tggcaggaag
    24361 aaacctattt gacttatgtg aaagatataa acaaacatca cattaatgca atggcgggta
    24421 tgtcttggca agagtataat tataccaaat tcgaagcttc cgacagtaag tatattgatg
    24481 acttctacgg atattataat ttaggttccg gaacgaaccg tccttctgta ggcaatgatt
    24541 acgacaagtg ggcgatgaac tcttatttct tgcgtctggc atattcttat gacaacaagt
    24601 atatggctac cgtaaccggt cgttatgatg gctcttccaa attcggacag aacaataaat
    24661 atgcattttt cccgtcagtc ggcttgggtt ggatgatttc taatgaagac tttttaaaag
    24721 ataactcatt gattagcaaa ctaaaattgc atacttctta cggtgtgaca ggtaattcgg
    24781 aaattggtac atataaatca ttggctacgg tgagccagtc gaatacgatc attggtgatg
    24841 ctctgcacgt agtgtcttat ctggacaata tgcctaatcc ggacctgaaa tgggaaaaga
    24901 caggacagtg gg
//
