LOCUS       c00280_gnlPro..        13927 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|IBBNHGCA_280.
ACCESSION   c00280_gnlPro..
VERSION     c00280_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-06 04:14:26
            Original ID  :: gnl|Prokka|IBBNHGCA_280
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 13927
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     CDS             1..300
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_fatty_acids: HBT"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg280_1"
                     /sec_met_domain="HBT (E-value: 1e-19, bitscore: 61.0,
                     seeds: 132, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="VDHRTRQPFGILHGGATLALAETVAGLGSMILCQPDEIVVGMQVS
                     GNHISSAHEGDTVRAVGTVVHKGRSSHVWNVDVFTSTNKLVSSIRVVNSVMKKR"
     protocluster    1..13927
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[0:3927]"
                     /cutoff="10000"
                     /detection_rule="(TPP_enzyme_C and (minimum(2, [ACD1_car,
                     ACP_syn_III_C, AcetylCoA_hyd_C, AcetylCoA_hydro,
                     Acyl-CoA_dh_1, Acyl-CoA_dh_2, Butyrate_kinase,
                     CT_Propionyl_CoA1, CT_Propionyl_CoA2, CT_Propionyl_CoA3,
                     Carboxyl_trans, CoA_trans, CoA_trans_230_acto,
                     CoA_trans_2_CAF, CoA_trans_6_Glutaconate, E1_dh, ECH_1,
                     ECH_2, HBT, HBT_2, HCDH, HpaB, Ketoacyl-synt_C, Thiolase_C,
                     Thiolase_N, adh_short, adh_short_C2]) or FA_synthesis) and
                     not (PFL-like or PFL_6_pcresol or PFL_9_tma or Gly_radical
                     or Gly_430_pcre or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and not
                     (POR or POR_N))"
                     /neighbourhood="10000"
                     /product="TPP_fatty_acids"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      1..3927
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(TPP_enzyme_C and (minimum(2, [ACD1_car,
                     ACP_syn_III_C, AcetylCoA_hyd_C, AcetylCoA_hydro,
                     Acyl-CoA_dh_1, Acyl-CoA_dh_2, Butyrate_kinase,
                     CT_Propionyl_CoA1, CT_Propionyl_CoA2, CT_Propionyl_CoA3,
                     Carboxyl_trans, CoA_trans, CoA_trans_230_acto,
                     CoA_trans_2_CAF, CoA_trans_6_Glutaconate, E1_dh, ECH_1,
                     ECH_2, HBT, HBT_2, HCDH, HpaB, Ketoacyl-synt_C, Thiolase_C,
                     Thiolase_N, adh_short, adh_short_C2]) or FA_synthesis) and
                     not (PFL-like or PFL_6_pcresol or PFL_9_tma or Gly_radical
                     or Gly_430_pcre or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and not
                     (POR or POR_N))"
                     /neighbourhood="10000"
                     /product="TPP_fatty_acids"
                     /protocluster_number="1"
     cand_cluster    1..13927
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(TPP_enzyme_C and (minimum(2, [ACD1_car,
                     ACP_syn_III_C, AcetylCoA_hyd_C, AcetylCoA_hydro,
                     Acyl-CoA_dh_1, Acyl-CoA_dh_2, Butyrate_kinase,
                     CT_Propionyl_CoA1, CT_Propionyl_CoA2, CT_Propionyl_CoA3,
                     Carboxyl_trans, CoA_trans, CoA_trans_230_acto,
                     CoA_trans_2_CAF, CoA_trans_6_Glutaconate, E1_dh, ECH_1,
                     ECH_2, HBT, HBT_2, HCDH, HpaB, Ketoacyl-synt_C, Thiolase_C,
                     Thiolase_N, adh_short, adh_short_C2]) or FA_synthesis) and
                     not (PFL-like or PFL_6_pcresol or PFL_9_tma or Gly_radical
                     or Gly_430_pcre or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and not
                     (POR or POR_N))"
                     /kind="single"
                     /product="TPP_fatty_acids"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..13927
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="TPP_fatty_acids"
                     /region_number="1"
                     /rules="(TPP_enzyme_C and (minimum(2, [ACD1_car,
                     ACP_syn_III_C, AcetylCoA_hyd_C, AcetylCoA_hydro,
                     Acyl-CoA_dh_1, Acyl-CoA_dh_2, Butyrate_kinase,
                     CT_Propionyl_CoA1, CT_Propionyl_CoA2, CT_Propionyl_CoA3,
                     Carboxyl_trans, CoA_trans, CoA_trans_230_acto,
                     CoA_trans_2_CAF, CoA_trans_6_Glutaconate, E1_dh, ECH_1,
                     ECH_2, HBT, HBT_2, HCDH, HpaB, Ketoacyl-synt_C, Thiolase_C,
                     Thiolase_N, adh_short, adh_short_C2]) or FA_synthesis) and
                     not (PFL-like or PFL_6_pcresol or PFL_9_tma or Gly_radical
                     or Gly_430_pcre or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and not
                     (POR or POR_N))"
                     /tool="gutsmash"
     CDS             297..1412
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Chorismate_bind"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg280_2"
                     /sec_met_domain="Chorismate_bind (E-value: 7.5e-58,
                     bitscore: 186.3, seeds: 119, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTDEEISNLTTIDAFIQRKQPFAVYRIPGEKVPRLLTQAEGAVRL
                     IYDLKELNGQRGFVIAPFQVSESCPVVLIQPDQWGQPLPVDDDTEEDREIALRLQGQES
                     FLTSSTEEYAACFHTFINALRDRTFDKLVLSRHLTVDKVADFSPLSIFRAACKRYIHSY
                     IYLCYTPQTGIWLGSTPEIILSGEKDEWHTVALAGTQPLQDGRLPQVWDEKNRKEQDYV
                     ASYIRRQLLSLDIHSTENGPYPAYAGALSHLKTDFRFSLKDNKGLGDLLKVLHPTPAVC
                     GLPKEEAYQFILQNEGYDRRYYSGFIGWLDPEGRTDIYVNLRCMHIEDKQLTLYAGGGL
                     LASSELNDEWLETEKKLQTIKRLIAVPPLKS"
     CDS             1690..3099
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_fatty_acids: TPP_enzyme_C"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg280_3"
                     /sec_met_domain="TPP_enzyme_C (E-value: 1.1e-07, bitscore:
                     22.0, seeds: 323, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="VAEAFYQNVPLVIISADRPAAWIGQMDGQTVPQPGVFQTLVKKSV
                     NLPEIHTEEDEWYCNRLVNEALLETNHHGKGPVHINVPISEPLFQFTVDSLPEVRVITR
                     YQGLNVYDRDYNDLVDRMNKYQKRMIIIGQMNLIYLFEKRYIKLLYKHFAWLTEHIGNQ
                     TVPGIPVKNFDAALYAMPEEKVGQMVPELLITYGGHVVSKRLKKFLRQHPPKEHWHVSP
                     DGEVVDLYGSLTTVIEMDPFEFLEKIASLLDNRTPEYPRVWENYCKIIPEPEFAYSEMS
                     AVGTLLKALPESCALHLANSSVVRYAQLYSIPSTIEVCCNRGTNGIEGSLSTAVGYAAA
                     SDKLNFIAIGDLSFFYDMNALWNVNVRSNLRVLLLNNGGGEIFHTLPGLDMSGTSHKFI
                     AAVHKTSAKGWAEERGFLYLQAQNDEELAEAMKTFTQPEAMEQPVLLEVFTNKNKDARM
                     LKNYYHQLKQK"
     CDS             3103..3927
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_fatty_acids: ECH_1"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg280_4"
                     /sec_met_domain="ECH_1 (E-value: 1.6e-82, bitscore: 266.7,
                     seeds: 9, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSTQREWTTIREYDDILFDYYNGIARITINRERYRNAFTPTTTAE
                     MSDALRICREEADIDVIVITGAGDKAFCSGGDQNVKGRGGYIGKDGVPRLSVLDVQKQI
                     RSIPKPVIAAVNGFAIGGGHVLHVVCDLSIASENAIFGQTGPRVGSFDAGFGASYLARV
                     VGQKKAREIWFLCRKYNAQEALDMGLVNKVVPLEQLEDEYVQWAEEMMLLSPLALRMIK
                     AGLNAELDGQAGIQELAGDATLLYYLTDEAQEGKNAFLEKRKPNFKQYPKFP"
     CDS             4100..5125
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) MR_MLE_C"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg280_5"
                     /sec_met_domain="MR_MLE_C (E-value: 9.3e-30, bitscore:
                     94.0, seeds: 401, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNCKIEIIPRLLHFKQPAGTSRGTYTTRKVWYLHFTSPDFPGRVG
                     IGECAPLPALSCDDLPDYEDILKRFCRQVEKEQGMWDKDVLCQYPSILFGLETAIWHFF
                     AGSWALSDTAFSRGEVGIQINGLIWMGDFDHMLSQIEKKMEAGFRCVKLKIGAIDFEKE
                     LALLRHIRTHFSSKEIELRVDANGAFSPGDAMEKLKRLSEFDLHSIEQPIRAGQWEEMA
                     RLTSESPLPIALDEELIGCNTLDEKKKLLATIRPQYIIIKPSLHGGICGGDEWIMEAEK
                     QHIGWWITSALESNIGLNAIAHWCATFNNPLPQGLGTGMLFTDNIEVPLEIRKDCLWFC
                     K"
     CDS             5157..6296
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) AMP-binding"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) AMP-binding_C"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1025:AMP-binding enzyme (Score: 53.7; E-value:
                     4.4e-17)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg280_6"
                     /sec_met_domain="AMP-binding (E-value: 1.3e-17, bitscore:
                     53.7, seeds: 145, tool: rule-based-clusters)"
                     /sec_met_domain="AMP-binding_C (E-value: 1.9e-09, bitscore:
                     28.8, seeds: 272, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIFDRQQQRLLLEGKEYTFEDISQLIAGGAEAHSSAYWNLYLFLN
                     EWFNDSPVITVHTSGSTGIPKELMVRKDQMMQSARLTCEFLNLKKGESALLCMNLRYIG
                     AMMVVVRSLVVGLNLIVRPASGHPLADIKEPLRFVAMVPLQVYNTLQVPEEKERLKQTD
                     ILIIGGGAVDEALETEIKYLPTAVYSTYGMTETLSHIALRRLNGASASEHYYPFPSVKL
                     SLSVENTLVIDAPLVCDEILQTNDIARIYPDGSFMILGRKDNVINSGGIKIQAEEMEKL
                     LRPFIPASFVITSVPDQRLGQAVTLLIVGQLDTRELENKLQTTLEPYYRPKHIFITESI
                     PQTENGKIDRVGCRTLAASYLSHSQQFPSIELHDDAKCS"
     CDS             complement(6864..7349)
                     /locus_tag="ctg280_7"
                     /transl_table=11
                     /translation="LYAKRFVDDKETREDIVSDVFTSLWDKLDTDSFDLQSNTALAYIK
                     MCVKNNCLNFLKHQEYEWSYAENIKKKTPIYETEPDSIYTLDELYRMLYETLDKLPENY
                     RTVFMKSFFEGKTHVEIAEEMNLSVKSINRYKQKTMELLRNELKDYLPLLLLLFYRT"
     CDS             complement(7534..7764)
                     /locus_tag="ctg280_8"
                     /transl_table=11
                     /translation="MINSLSIPGSVCETPDYESKNKRRRLLIKVRSVIQLKYIYSIGYY
                     FKFNNINNTNRMPKKDREIKLFFIFFRIQLK"
     CDS             7805..9100
                     /locus_tag="ctg280_9"
                     /transl_table=11
                     /translation="VKQDEFVGNIESFSNKFINQQKLKNMKRLSFLLMAVVCVIFFSCG
                     EDEDKQGHSITAFTGYGGAIATADKEIAVAGEAVTVTATPADGFLFKEWKVRVGNTIVE
                     NVQANPSTFTMPMEDVVIVATFMIRNDVLERITDPALKAYCQSRMDTEQEIDGVTYPKW
                     DTNGNGVLSPDEASAVKAIDITGGVNGVKIKSVDELVEFAGLEVLKISGNELTTLNVAW
                     PKLAQLDCSHNKLSNLSVGKSENLKELYCNNNHLSSLKLKAMLYEDGFMLHCGNQTTID
                     GEARTVEVLLSEEQIAFWESNLKKLNENVNVEVQTMPNTDVYLTMTDAYKYSYGSLTLI
                     LSDDDSNRIQLSLKLSELQPGEYSKAQINSAYVTVTGGGSYRSLDSDDPGSFIVKYDAV
                     SDIYTIEGVLNLRADASYPSVNIVGFEYTGPL"
     CDS             9273..10193
                     /locus_tag="ctg280_10"
                     /transl_table=11
                     /translation="MNNKELEASFRKAKALGDDIREMESIDALAAYRQSQMKIRGLKRT
                     RLHNQLIRCAAFLAIPLLLASLILGYLYFAESEEEIRYAEVISTMGTVVRYELPDHSVV
                     WLNSGSKLRYPTVFQKDNRNVELTGEAYFQVEAEPERPFYVNTPNGLSVYVYGTQFNVT
                     AYEDDNYIETVLEKGKVNVLPPGQKTITLLPGEQLVYDKQTRQVQKNKVDVYGKVAWKD
                     GKLIFRNASLEEIIKRLERHFNVDIEFNNHLGKEYSYRATFRTETLTQILDYLAKSANL
                     KWKILTPEQREDDTFTKTKIIVDLY"
     CDS             10378..13767
                     /locus_tag="ctg280_11"
                     /transl_table=11
                     /translation="MKKNHSFIALCFKYALNLKLPLVMRISLTLLFAVVLQLSAANGYA
                     QRIRGVISMNNVSIEQVLNKIEESSDYVFLYNDKAIQKNRIVSVNNNSGKIQDILDEIF
                     RGTSISYTVVDKQIILSAKPFVQKTMEDATIPVKGIVKDVNGEPLIGVNVKVKGSNVGT
                     ITDIDGNFTIRTKKGDVLEFSYVGYTVQNVTITGNTTLNIVLQEDNAVLDEVVVTALGI
                     KRSDKALSYNVQKLGDAQFMSVKEASVPNALNGKVAGVTISQGASGIGGSTKVVMRGSK
                     SVNAEGNNNALYVLDGIPLPDLFPRRGATSNAQYGGVDEGDGISNINMEDIAEVTVLTG
                     PSAAALYGGQAANGVIMLTSKQGGLKDGKPRISFSHYSDFYQPLLLPKLQNTYGSRTDE
                     FSSWGPKLETPANYDPADFFDTGMSFSNSIGAQLGTENHKSYISLSSYNARGVVHNNNL
                     DRYNVSYNGTYTITDKLSLGATFMYTNKKAQNMLSQGDYYNPIVPIYLFPRGDNIDKYK
                     SYERYSADRGFPVQFWPYGDQKRSIQNPYWITHRNFNINHNERFIIGGSLKYTFNEWFN
                     ISARFRTDRDNKKNEIKNYASTLLLLASSSDKGSYLLATEKNIQDYGDVIANFQKTVSD
                     WGFVVNAGASFKNASFDYTANSNKLEFGAPLASVANKFTLNNLTPEPQYQEGKKMKSQA
                     VFFSASVDWKRKIFLDVTGRNEWTSLLANTKNKSFFYPSVGMSFVLTEFFKVPEKILTF
                     SKLRLSYAKVGNVPMSLAGITIPSYPISPGGGVSINPDLPIDNLKFEKTQSFEIGLNAR
                     FLNNKLGLDITYYNANTYDQLFKFRAPESSGYANFYVNAGKVNNKGLEASIDADLTFGD
                     FNYSPKLTVTYNKNKIVELVRNIPNPFTGADMNVSHFDMGGLSYSFRNYIDEGGSIGDI
                     YVNSVKKDGNGYVYVNPNTLSMMVDNENLIYAGNTNPDCSLGFNNAFSYKGFTLSFLID
                     ARIGGKVVSATQAVLDSFGASEQSAKARDNGGVLVNGVLMDAETYYTQVGAGTGVLSNY
                     VYDATNIRLREASLSYRFKPLFKNFVKDLTLSVTGRNLFMIYNKAPFDPQLTSSVGTFY
                     QGIDYFMMPSLRSFGVSLKFTL"
ORIGIN
        1 gtagaccatc gtacccgtca gccttttggc attttgcatg gtggagctac tcttgcgttg
       61 gcggaaacag ttgccggact cggttcgatg attctttgcc agccggacga gattgtagta
      121 ggaatgcagg tcagcggaaa ccatatatct tctgcacatg aaggagatac cgtgcgtgca
      181 gtaggaacag ttgtacataa aggacgttcc tcccacgtat ggaatgtaga cgtgtttact
      241 tcaacaaaca aactggtgtc ttccatacgg gtagtcaaca gtgtgatgaa aaagagatga
      301 ccgacgaaga aataagtaac ttgacaacta ttgatgcatt tattcagcgg aagcagccgt
      361 ttgctgttta ccgtattccc ggagagaaag ttccccgtct gttgacgcag gcggaaggag
      421 cggtccgttt gatatacgat ttgaaagaac tgaatggaca gagaggattt gtaattgctc
      481 cgtttcaggt gagtgagtca tgtccggttg tgttgattca acccgatcag tgggggcagc
      541 ctttacccgt ggatgatgat acggaagaag atcgggagat agccttgcgc ctgcaaggac
      601 aagaatcatt tctgacttct tctacggaag aatatgcggc atgctttcat acctttataa
      661 atgcgttacg tgacaggacg tttgataaac tagtgctttc ccgtcatctt acagttgata
      721 aagttgcgga tttttctcct ttgtccatct ttcgggcggc ttgtaaacgt tatattcatt
      781 cgtatattta cttatgttat actccgcaga cgggcatctg gctgggaagt actcccgaaa
      841 tcattttatc aggtgagaaa gacgaatggc atacggttgc actagccgga acacagcctt
      901 tgcaagatgg cagattgccg caagtatggg atgaaaagaa ccggaaagaa caagattatg
      961 ttgcttctta tatccgtcgg cagcttcttt cactggatat tcattctacg gaaaacgggc
     1021 catatcctgc ttatgccggt gctttgtcac atttaaaaac tgatttccgt ttttctttga
     1081 aagataataa aggtttggga gaccttctga aagttttgca tccgacacct gccgtatgcg
     1141 gcttgccgaa ggaagaagcc tatcagttta ttttgcagaa tgaaggttac gaccgccgct
     1201 attactccgg ctttatcgga tggctcgatc cggaaggacg aacagacatc tatgtaaact
     1261 tacgctgtat gcatatcgaa gataaacaac ttactcttta tgccggcggt ggattattgg
     1321 cctcttcgga attgaatgac gaatggctgg aaacggagaa gaagttgcaa accatcaaac
     1381 ggctgattgc agtgcctcct ttaaaatcat aaactactaa taattatcat catgtataca
     1441 gacaagaaga acatactcca gttggttgcg ttgctcgagg cgcatgggat tactaaggtt
     1501 gtattgtgtc cgggtagtcg taatacgccc atagtacata ctttgtctaa ccatccgaat
     1561 tttacctgct atccggtgac ggatgaacgg agtgccggct attttgccat cggtcttgcg
     1621 ttgaatggtg gtaagcccgc agctgtctgt tgcacttccg gtactgcatt attaaacctt
     1681 catccggctg tggcagaagc attttatcaa aatgttcctc tggtcattat ttctgcggat
     1741 cgtcccgctg cctggatcgg gcagatggat ggacagacag taccacaacc aggcgtattt
     1801 cagacattgg ttaagaagtc agtaaacctt ccggagattc atacggaaga agatgaatgg
     1861 tattgcaatc gtctggtgaa tgaagctttg ctggaaacga accatcatgg aaaaggaccg
     1921 gtacatatta atgtccctat ttctgaaccg ttgttccagt ttacggttga ttcgcttcct
     1981 gaagtgcgtg tcattacccg ttatcagggg ttgaacgtct acgatcgtga ttataatgat
     2041 ttggtcgatc ggatgaataa ataccagaag cgaatgatta tcatcggtca gatgaatctt
     2101 atctacctgt ttgaaaaaag atatatcaag ttattatata aacattttgc ctggttgact
     2161 gaacatatcg gcaaccagac agttcccggt attccggtaa agaactttga tgcggcgctt
     2221 tatgccatgc ccgaagagaa ggtcggccag atggttccgg agttgttgat tacttatgga
     2281 ggacatgtcg tttccaaacg gctgaagaag tttctccgtc agcatccgcc taaagaacat
     2341 tggcacgtat cgccggatgg tgaggtggtc gatttgtacg gctcattaac tacggtgatc
     2401 gaaatggacc cgttcgagtt tctggagaag atagccagtt tgctggacaa tcggactcct
     2461 gaatatcccc gtgtgtggga aaactattgc aagatcattc ccgaaccgga gtttgcttat
     2521 tcggaaatgt ctgccgtcgg tacgttattg aaagccttgc cggagtcatg tgcgttgcat
     2581 ctggcaaaca gttcggtggt gcgttatgcg caattatact ccattccttc tacgattgaa
     2641 gtttgttgca accgggggac aaacggcatt gaaggctcac tgtctacggc tgtcggttat
     2701 gcggcagctt ccgacaaact gaactttata gctatcggag atttgagctt tttctatgat
     2761 atgaatgcat tgtggaatgt caatgttcgc tccaatctgc gtgttcttct gttaaataat
     2821 ggaggaggag agattttcca taccttgccg ggattggata tgtcgggtac ctcacataaa
     2881 tttattgcgg cagtccataa aacgtcggcc aaaggttggg cggaggaacg tggattcctc
     2941 tatctgcaag cacaaaatga cgaagaactg gctgaagcga tgaaaacttt cactcaaccg
     3001 gaagctatgg aacagcctgt gctcttggag gtgtttacca acaaaaacaa ggacgcgcgc
     3061 atgttgaaga attattatca tcaattaaaa caaaaataga ttatgtcaac acaaagagag
     3121 tggacaacca ttagagaata cgacgatatt ctttttgatt attataatgg aattgcccgt
     3181 atcacgatca accgtgaacg ctatcggaat gcgtttactc cgacaactac tgctgaaatg
     3241 agtgacgcat tgcgcatctg ccgtgaagaa gcggatattg atgtgattgt gattaccgga
     3301 gccggtgata aggcattttg ttcgggcggc gaccagaatg tgaaaggacg tggcggatat
     3361 atcggaaaag acggtgtgcc tcgtcttagc gtattggatg tgcaaaagca gattcgcagc
     3421 atcccgaaac cggtgattgc tgccgtgaac ggttttgcta ttggtggcgg acatgtgctt
     3481 catgtggtat gtgatttgtc cattgcgtcg gaaaatgcta ttttcggtca gacgggtcct
     3541 cgtgtaggta gctttgatgc tggattcggt gcgtcttatc tggcacgtgt ggtcggtcag
     3601 aagaaagcac gcgaaatctg gttcctctgc cggaagtata atgcacaaga agcattggat
     3661 atgggattag tgaataaagt agttcccttg gagcagttgg aagatgaata tgtgcagtgg
     3721 gcagaagaaa tgatgctgct tagtccgttg gctttgcgca tgattaaagc aggattgaat
     3781 gccgaactgg atggtcaggc aggtattcag gaattggcag gtgacgcaac gttgctctat
     3841 tacctgactg atgaagcaca ggaaggaaag aatgcgtttc tggagaaacg taaaccgaac
     3901 ttcaaacaat atccgaaatt cccttaaaat cggctttgcc acagagtacc acagagtttg
     3961 cttttcctgc gtttaagccc gattttctgc aaagcaagac tgtggaggag agaatggtag
     4021 gagaactgca agagatataa cttgttaaaa cttcgtgagg ctctgtgtta ttctgtggtg
     4081 aattgaaaaa ttattcacga tgaattgtaa aatagaaatt attccccgat tgctccattt
     4141 caagcaacct gccgggactt ccagaggaac atatactacg cgtaaagttt ggtatcttca
     4201 ttttacctct cctgacttcc ctggcagagt gggaataggg gagtgtgcac ctttgcccgc
     4261 tttaagttgt gacgatcttc ctgattacga agatatatta aaaagatttt gtcggcaagt
     4321 agagaaagaa caaggaatgt gggataagga tgttttatgc cagtatcctt ccatcttatt
     4381 tggcttggaa acggctatct ggcatttctt tgcagggagt tgggctttgt ccgatacggc
     4441 tttttctcgt ggagaggtag ggattcaaat taatggtttg atttggatgg gagattttga
     4501 tcacatgtta tcccaaatcg agaaaaagat ggaagccgga ttccgttgtg tcaaactaaa
     4561 gattggtgct atcgattttg aaaaagaatt ggcgttgtta cgccatattc gtacccattt
     4621 ctcttctaaa gaaatagagt tgcgtgtaga tgcaaacggt gctttctctc cgggtgatgc
     4681 aatggaaaaa ctgaaacgtc tgtcggaatt tgatttacat tctatcgaac agccgatccg
     4741 tgccggacaa tgggaggaaa tggcccggct cacttctgaa tctccgttgc cgatagcatt
     4801 ggatgaagag ctgataggat gcaacacgct ggatgaaaaa aagaaactgc tggcaaccat
     4861 ccgtccgcaa tatatcatca ttaaaccatc tctccacgga ggaatatgcg gaggagatga
     4921 atggattatg gaagcggaaa agcaacatat cggctggtgg atcacttccg ctttagagtc
     4981 caacattggt ttgaacgcta tcgcccattg gtgtgcaaca ttcaataatc cgttgccaca
     5041 aggattggga acgggtatgc tctttactga caatatagaa gtgcctcttg aaatcagaaa
     5101 agattgcctg tggttttgta aatgatggta tttagtggta tttaaaggat attctgatga
     5161 tatttgatcg acaacaacag cgcttgctac tggaaggaaa agaatacact tttgaagata
     5221 taagccaact gatagcagga ggagcagaag ctcattcttc tgcttattgg aatttatatc
     5281 ttttcctgaa cgaatggttt aatgattctc ctgttattac agttcataca tcgggctcca
     5341 cgggtatacc taaagaactg atggtacgca aggatcaaat gatgcaaagt gcgcgtctga
     5401 cttgtgaatt tctgaatttg aagaaaggtg agtcggcatt attatgcatg aatcttcgtt
     5461 atatcggtgc aatgatggtg gtcgtacgtt cattggttgt aggtttgaat ttgattgtac
     5521 gtcctgcttc cggtcatcct ttagcggata taaaagagcc tttgagattt gtggcaatgg
     5581 ttcccctgca agtttataat acgttgcaag ttcccgaaga gaaagaacga ttaaagcaaa
     5641 cggatattct gattatagga ggcggagccg ttgatgaggc tctggaaacg gagataaaat
     5701 atcttccgac tgccgtttat tccacttatg gcatgactga aaccttgtcg catattgccc
     5761 ttcgtcgtct gaatggagca tcggcttcag aacattatta tccatttcct tcagtaaaac
     5821 tgtctttatc cgtagagaac acattggtga ttgatgcccc ccttgtctgt gatgagattt
     5881 tgcaaaccaa tgacattgca cgtatctatc ccgatggaag ttttatgatt ctaggccgga
     5941 aagataatgt gattaacagt ggaggaatta agattcaagc agaagagatg gagaagttac
     6001 ttcgcccgtt tattcctgcg tcctttgtca ttacttcagt tccggatcag cgcttagggc
     6061 aggctgtcac tttattgata gtgggacaat tggatacgag agagctagaa aataagttgc
     6121 agacaacatt ggaaccatac tatcgtccca aacatatttt tattacagaa tctattccac
     6181 agacggaaaa cggcaaaata gaccgggtcg gctgccgcac tttggcagca tcataccttt
     6241 cccattcgca gcagttccca tccatagaac tacatgatga tgcaaaatgt agttgaggtt
     6301 cccggtaaaa ctagtgaact tgtaaattga ggaacttagg gagcctcccc cccccagagt
     6361 gatttggcaa ttctatttct catattctca tgaatataag tcaacctgtt gaaacataat
     6421 gtaatagaat atgagaaata cttttaaaag ttggcatttc tcatattttt cctgtgctct
     6481 gtccctaaaa acaggcattt ctcatactca ttcttgttat ttctcatagc agttgtataa
     6541 caatctactg ctattttacg cttgaatcat taacagtaaa gttattcttc attatagata
     6601 aacttgtttt gggttaatag taaacttgtt ttttacctat tataaactat aattgtaagc
     6661 tttgattata taattgcaag tttcattttt ataaatgcaa cctttgatta taaaaacgaa
     6721 gcttgcattt atagtttatg attagtcaaa agtaacttta tatataaagg attggaagtt
     6781 tgctattagt caaaagcaac tttactatta atatttttca gacggaaaag taatagtttg
     6841 tatgtgatga taaggagaga ctgttatgtg cgatagaata acaaaagtaa caatggcaga
     6901 tagtctttca gttcattgcg caaaagttcc attgtctttt gcttgtaacg gttgatggat
     6961 ttcacactga gattcatctc ttctgcaatt tctacatgcg ttttgccttc aaagaagctt
     7021 ttcataaata ctgtacgata gttttccgga agtttgtcca atgtttcata caacattctg
     7081 tatagttcat caagagtata tatactatcc ggttctgttt cgtaaattgg agttttcttc
     7141 ttaatatttt ccgcatagct ccattcatat tcctgatgtt tcaagaaatt caggcagtta
     7201 tttttcacac acattttaat gtaagctaat gcagtgttcg attgaagatc aaaagagtca
     7261 gtatccagtt tatcccataa tgaagtgaat acatccgaaa cgatgtcctc acgtgtttct
     7321 ttatcgtcaa caaacctttt ggcatacaaa caaaatgggg cataatattc ctcataaagt
     7381 tgcttgaaag cccgttcttt agtctgtttg gaaaaagaaa ttttcattat ttagggattc
     7441 tgtgtttttt cattttgcta caaatatata atacaataat tgattaaccc taatttccca
     7501 ttcttttttt gtgtttcagt tggtattatc gtttcatttt aactgaattc ggaaaaaaat
     7561 aaaaaaaagt ttgatttctc tgtccttttt aggcatccta tttgtattat taatgttgtt
     7621 gaacttaaaa taatagccta tggaatatat atatttcaat tgaataacac tacgaacctt
     7681 gattaacaat cttcttcttt tgtttttaga ttcatagtcc ggggtctcgc aaacgctgcc
     7741 gggaatcgaa agtgagttta tcatcagtat gaatgtggat aagtgaggat aattcaccgc
     7801 cttagtgaaa caagatgagt ttgttggtaa cattgaatca tttagtaata aatttattaa
     7861 tcaacaaaaa ttgaaaaaca tgaaacgatt gagtttttta ttgatggctg tagtttgtgt
     7921 tatattcttt tcgtgtggag aagatgaaga caagcagggt cattcaatta ctgcatttac
     7981 cggttatggc ggcgccattg caacagctga taaggaaata gccgtagcgg gagaagctgt
     8041 gactgttacg gctactcctg ctgatggatt tttatttaaa gaatggaaag taagagtcgg
     8101 taatactata gttgagaatg tgcaggcaaa tccttccaca tttactatgc ctatggagga
     8161 tgtagtaatt gtagctacat ttatgataag aaatgatgtg cttgaaagaa taaccgaccc
     8221 tgcattgaaa gcttattgtc aatccagaat ggatacagag caggaaatag acggagttac
     8281 ttacccgaag tgggacacga atggtaacgg tgtactttcc cctgatgaag cgtcagcagt
     8341 aaaagctatt gatattaccg gtggggtgaa tggagtcaaa ataaaaagtg tggatgaatt
     8401 ggttgaattt gcaggactgg aagtgttgaa aattagtgga aatgaattga ctacattaaa
     8461 tgtagcatgg cctaaacttg cacaacttga ttgtagccat aataaattga gcaatttgtc
     8521 cgtaggaaaa agtgaaaatc ttaaagagtt atattgtaac aataatcatt tgtcctcatt
     8581 gaagttgaag gctatgctat atgaagatgg ttttatgctt cattgtggta accaaacaac
     8641 aatagatgga gaagcccgga cagttgaagt gttattgtct gaggaacaaa tcgctttttg
     8701 ggaaagtaat ctgaaaaaac tgaatgaaaa tgtaaatgta gaagttcaaa ctatgcctaa
     8761 tactgatgtc tatttaacaa tgactgatgc atataaatat tcgtatggca gtttgacgct
     8821 aatactttcg gatgatgata gtaatcgtat acaattaagt ttgaaattat ccgaattaca
     8881 accgggagaa tattctaaag cccaaataaa tagtgcatat gtgacagtaa caggtggtgg
     8941 cagctataga agcttagact ctgacgatcc cggttcgttt attgtaaaat atgatgcggt
     9001 tagtgatatt tatactatag agggggtatt aaatttgcgg gcagatgcgt cgtatccttc
     9061 tgttaatatt gtgggatttg aatatacagg accgttgtag tctatatcaa tagagaagag
     9121 aatggaaaaa catccgtaga ttttccttat atgtagatta aagagtctac ggatgttttt
     9181 ttcagattat tgaaaaatga ttggcttttg atgtcccttt tcaatgagtc gattgtacta
     9241 ttaatatagt tgcaattata aaaaaaggaa gtatgaataa taaagaactg gaggcatcat
     9301 tccgcaaggc gaaagctttg ggtgatgata ttagagaaat ggagtcgatt gatgcattag
     9361 ctgcttatcg acagtctcaa atgaagatta gagggctgaa aagaacgaga ctgcacaatc
     9421 aactgatacg ttgtgctgca tttctggcca taccgttgct attggcttca ttgattttgg
     9481 gatatttata ttttgcagag tcggaagaag aaataagata cgcagaagtt atttctacca
     9541 tgggaacggt ggtgcgttat gaacttccgg accattctgt tgtctggctt aattctggta
     9601 gtaaattgcg ttatcctact gttttccaaa aagacaaccg caatgtggaa ctgactggtg
     9661 aggcttattt tcaagtggag gcagaaccgg agcgtccgtt ttatgtgaat acgccgaatg
     9721 ggttgagcgt atatgtgtat ggtacgcaat ttaacgtgac agcttacgag gacgataact
     9781 acatagaaac tgtattggaa aaaggtaaag tcaatgtact gcctcctgga caaaaaacga
     9841 ttacattgct tcccggtgaa cagttggttt atgacaaaca gacccgccag gtgcagaaaa
     9901 ataaagtgga tgtttatggg aaggtggctt ggaaggatgg aaaattgata ttccggaatg
     9961 cttcgttgga agaaataatc aagcgtctgg aacgtcattt caacgtagat attgaattca
    10021 ataatcattt gggaaaggag tatagctatc gggccacttt cagaacggaa acattgacgc
    10081 agatattaga ttatttagct aagtcggcaa acctgaaatg gaagattttg actcccgaac
    10141 aacgggaaga tgatacattt acaaagacga aaataatagt agatttatat tagtaatcat
    10201 ctgaaaaaac aaatagccta tgatataaca catattgata atcaaaaaag ggaggagggc
    10261 cgctaccaac ggctgtcttc tcccaaatct aagattcacg gtacagggtc tcgcaaacgc
    10321 taaccggaat caacacctta gttcatttag taataaactt tagtcagcta caaatgtatg
    10381 aaaaaaaatc attcatttat tgcattatgc tttaaatatg ctttaaatct aaaacttcct
    10441 ttagttatga ggattagtct aacattactt tttgcagtcg tattgcaact ttctgcagca
    10501 aatggctatg cccaacgtat acggggagtc atttcgatga ataatgtatc tattgaacag
    10561 gtactgaata agatagagga aagttcggat tatgtgttcc tttataatga taaggcgatt
    10621 cagaagaacc gcattgtttc agtgaataat aattccggca agatacagga tattctggat
    10681 gaaatattcc ggggcacttc tatatcttat acggtggtgg ataaacagat tattctttcc
    10741 gcaaaacctt tcgtacagaa aacaatggaa gatgcgacta ttccggtaaa aggtatagta
    10801 aaggatgtga atggcgaacc tcttattgga gtaaatgtaa aagtaaaagg ttcaaatgtc
    10861 ggtacaatta cagatattga cggtaatttt acgattagga cgaagaaagg agatgtcctt
    10921 gaattttctt atgtaggata cacggttcaa aatgtaacaa ttacgggaaa tacgactttg
    10981 aatattgtac ttcaagaaga caatgcagtg cttgatgaag tcgttgtcac tgcattgggt
    11041 atcaagcgtt cggacaaggc attgagttat aatgtgcaga aattgggcga tgcacagttt
    11101 atgtctgtca aggaagccag tgtgccgaat gcgttgaacg gtaaggtggc aggtgtcaca
    11161 attagccaag gggcttccgg tatcggtgga tccacaaagg tggtgatgcg tggtagcaag
    11221 tctgtaaacg cggaaggaaa caataatgca ttgtatgtgt tggacggtat accgcttccc
    11281 gatcttttcc cgcggagagg ggctacctct aatgcacagt atggaggagt agacgaaggt
    11341 gacggtatct ccaatatcaa tatggaggat attgcggaag tgactgtgtt gacaggacct
    11401 tcggcagctg ctctctatgg tggtcaggct gcgaatggag taatcatgtt gacctccaaa
    11461 caaggaggac tgaaagacgg aaagcctcgt atttcattct cccattattc cgatttctac
    11521 caaccacttc tcttgccaaa gttgcaaaat acgtacggaa gtcgtacgga tgaattttcc
    11581 agttggggac cgaagctgga gactcctgcg aattatgatc cggcagattt ctttgacacg
    11641 ggtatgagtt tctctaacag catcggggca cagttgggaa cggagaatca taaatcctat
    11701 atttcccttt cttcttacaa tgcccgtggg gtagttcata ataacaacct cgaccgttac
    11761 aatgtttcct ataatggtac atataccatt acggacaaac tttctttggg agctactttt
    11821 atgtatacga acaagaaagc gcagaatatg ctttcgcaag gtgactatta taatccgatt
    11881 gtaccgattt atctgtttcc tcgcggtgat aatatagata agtataaatc ttatgagcgg
    11941 tatagtgcgg acagaggatt cccggttcaa ttctggccct atggcgacca aaagagaagc
    12001 atccagaatc catattggat tacacaccgc aatttcaata taaaccataa tgaacgtttt
    12061 attatcggtg gaagtttgaa atatacgttc aatgaatggt ttaacatcag tgcccgtttc
    12121 cgtacggacc gtgataacaa gaagaatgaa atcaaaaatt atgcttctac attgctgttg
    12181 ctggcttcca gctcggataa aggctcgtac ttgttggcaa cggaaaagaa tatacaggat
    12241 tatggagatg tgattgccaa tttccagaaa acggtatcag actggggatt tgtagtcaat
    12301 gcgggtgcca gctttaagaa tgcttcattc gattatacgg ccaattctaa caaactggaa
    12361 ttcggagcac ctctcgccag cgtagccaat aagtttacat tgaacaacct gactccggaa
    12421 ccccaatatc aggagggtaa aaagatgaag tcgcaagctg tattctttag tgcttctgtg
    12481 gattggaaaa gaaaaatatt ccttgatgta accggacgta acgaatggac ttcgttgctt
    12541 gccaatacca agaacaagag tttcttctat ccgtcggtag gtatgtcttt tgtgttgaca
    12601 gagttcttca aagtgccgga gaaaatattg acgttctcca agcttcgtct gtcgtatgct
    12661 aaggtaggaa atgtgccgat gtcacttgct ggaattacta ttccgtctta tccgattagt
    12721 ccgggcggtg gtgtaagtat caatcccgac cttcctatcg acaatttgaa gtttgaaaag
    12781 acacagtcgt ttgaaattgg tttgaatgcc cgtttcctga ataacaagtt aggattagac
    12841 ataacatatt ataacgctaa cacctacgac cagttgttta agttcagagc accggaaagc
    12901 agcggttatg ccaatttcta tgtgaatgcc ggtaaagtaa acaataaagg tcttgaggct
    12961 tctattgatg cggatttgac attcggagat ttcaattatt caccgaaact tacggtaacc
    13021 tacaataaaa acaaaattgt ggaattggtg agaaatattc ctaatccgtt taccggagcc
    13081 gatatgaatg tttcacattt cgacatggga ggactttctt attcattccg taactatatt
    13141 gatgaaggtg gttctatcgg tgatatatat gtcaattcgg tgaaaaaaga cggaaacgga
    13201 tatgtatatg tgaatccgaa taccttgagc atgatggtgg acaatgagaa tttgatttat
    13261 gcgggaaata ccaatccgga ttgttctttg ggatttaaca atgcgttcag ctataaaggg
    13321 tttacgcttt ccttcctgat tgatgcccgg attggcggaa aagtggtttc tgccacacaa
    13381 gctgttctgg attctttcgg tgcatctgaa cagagtgcaa aggcgcgtga caatggtggc
    13441 gtgcttgtaa acggagtgct gatggatgca gaaacttact atactcaagt gggggcaggt
    13501 acaggcgtgt tgtccaatta tgtatatgat gctaccaata tacgtttgag ggaagcttcg
    13561 ctttcttatc gtttcaaacc attgttcaag aactttgtga aggatttgac tctgtccgtg
    13621 accggacgta atttgtttat gatttataat aaggctcctt ttgacccgca actaacctct
    13681 tcagtgggta ctttctatca aggtatagac tatttcatga tgccgagttt aagaagcttc
    13741 ggtgtgagtc ttaaatttac attataatta aattaacaaa cagatgaaaa tgatactaaa
    13801 taatagatat ttcggcaaaa gtctgcttct ggtttctgct tgttctttgt ggatattagg
    13861 agcttgtaca ggagatttca tggagacaaa taccgatccc aatgctgtga cggaagaaga
    13921 gctggga
//
