LOCUS       gnlProkkaOGMDNEFB_35   15216 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|OGMDNEFB_35.
ACCESSION   gnlProkkaOGMDNEFB_35
VERSION     gnlProkkaOGMDNEFB_35
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2024-11-30 23:39:17
            Original ID  :: gnl|Prokka|OGMDNEFB_35
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 32532
            Orig. end    :: 47748
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..15216
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="True"
                     /core_location="[10000:10351]"
                     /cutoff="10000"
                     /detection_rule="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /neighbourhood="10000"
                     /product="RRE-containing"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..10351
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /neighbourhood="10000"
                     /product="RRE-containing"
                     /protocluster_number="1"
     cand_cluster    1..15216
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /kind="single"
                     /product="RRE-containing"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..15216
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="RRE-containing"
                     /region_number="1"
                     /rules="minimum(1, [Bottromycin_Methyltransferase_RRE,
                     Cyanobactin_D_RRE, Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /tool="antismash"
     CDS             complement(517..1341)
                     /locus_tag="ctg35_32"
                     /transl_table=11
                     /translation="MISLTKRKELKGYKSLKAYPEVAHFVTTRHGGISSGAYASFNCSP
                     YTNDSSMNLIRNRHWLFQLMKWEIQELFIAEQRHGAASMVIDKWYFDTSEGIRQDLLIG
                     IDALITNVPGYCVCVTTADCVPVLLYDKKLQVVAAIHAGWKGTVKHIVSNVLEHMNQKF
                     GTQGEDVIACIGPSISLASFEVGDEVYEAFKESGFDMSLISVKKRKTGKYHIDLWEANR
                     IELLNAGVPAEQIEVAGICSYIHHDEFFSARRLGIDSGRTLSGIMIRKESNN"
     CDS             complement(1338..2501)
                     /locus_tag="ctg35_33"
                     /transl_table=11
                     /translation="MAESNFVDYVKIYCRSGKGGRGSTHMRREKYCPNGGPDGGDGGRG
                     GHIILRGNRNYWTLLHLKYDRHAMAGHGESGSKGRSFGKDGADKIIEVPCGTVVYNAET
                     GEYLCDVTEDGQEVVLLKGGRGGQGNWHFKTATRQAPRFAQPGEPMQEMTVIMELKLLA
                     DVGLVGFPNAGKSTLLSSISAAKPKIADYPFTTLEPNLGIVSYHGGKSFVMADIPGIIE
                     GASQGKGLGLRFLRHIERNSLLLFMVPADSDDIRKEYEVLLKELRTFNPEMLDKQRVLA
                     VTKSDMLDQELMDEIEPTLPEGIPHVFISSVSGLGISVLKDILWEELNKESNKIEDIVH
                     RPKDVTRLQQELKDMGEDEDIVYEYEEDVDDDDDIDYEYEEEDWEEK"
     CDS             complement(2591..3160)
                     /locus_tag="ctg35_34"
                     /transl_table=11
                     /translation="MLNIVIFGAPGSGKGTQSERIVEKYGINHISTGDVLRAEIKNGTE
                     LGKTAKGYIDQGQLIPDELMIDILASVFDSFKDSKGVIFDGFPRTIAQAEALKKMLAER
                     GQDVSVMVDLDVPEEELMVRLIKRGKDSGRADDNEETIKKRLHVYHSQTAPLIDWYKNE
                     KKYQHINGLGTMEGIFAEICEAVDKL"
     CDS             complement(3220..3756)
                     /locus_tag="ctg35_35"
                     /transl_table=11
                     /translation="MDTIQIKDKLFTVSIKEQEIQKEVIRVANEINRDLAGKNPLFLSV
                     LNGSFMFTADLLKHITIPCEISFVKLASYQGITSTGVIKEVIGLNEDIAGRTIVIVEDI
                     VDTGLTMQRLLETLGTRNPEAIHIASLLVKPEKLKVNLNIEYVAMEIPNDFIVGYGLDY
                     DGFGRNYPDIYTVVD"
     CDS             complement(3797..5341)
                     /gene_functions="transport (smcogs) SMCOG1202:major
                     facilitator transporter (Score: 46.8; E-value: 2.5e-14)"
                     /gene_kind="transport"
                     /locus_tag="ctg35_36"
                     /transl_table=11
                     /translation="MSALKGHPKGLYLIFATSTAERFSYYGMRAIFILFLTQALLFDKE
                     AAASIYGSYTGLVYLTPLIGGYIADKYWGIRRSVFWGAVMMAVGQFLMFMSASTLDNTN
                     LAHWMMYGGLGFLILGNGCFKPTVSSLVGQLYEPGDRRLDAAYTIFYMGVNVGSFAAPL
                     ICGYLGDTGDPHDFKWGFLAAGIMTLFTVVLFETQKNKYLFSPSGEPIGIIPDAKREKK
                     EDKADHISHPKMDKRTKVRNTLVITILTIALIAFFNYAFEGDWVSIGIFTACIVFPVLI
                     LLDGSLTKIERSRIFVIYIVAFFVIFFWAAYEQAGASLTLFASEQTNRDIFGWEMPASW
                     FQSFNPLFVVVLAYIMPGVWGFLNKRKMEPASPTKQAIGLLLLSLGYLFICFGVKDAVP
                     GVKVSMIWLTGLYFIHTMGEIALSPIGLSMVNKLSPLRFASLMMGIWYLSTATANKFAG
                     MLSGLYPEAGKVKSIFGYQIATMYDFFMVFVVMSGVASLILFLLSKKLQKMMHGVE"
     CDS             complement(5535..5759)
                     /locus_tag="ctg35_37"
                     /transl_table=11
                     /translation="MMEKTKIGLNAGKVWRILNEKGELSMFDLCRELSLTFEDVALAIG
                     WLAREDKIFLRKREGMLFASIENVEFTFG"
     CDS             6430..6546
                     /locus_tag="ctg35_38"
                     /transl_table=11
                     /translation="MRNTLKYYENKVAFEPKYGRTYEKYRFEKVFLIRYLFD"
     CDS             7008..8519
                     /locus_tag="ctg35_39"
                     /transl_table=11
                     /translation="MKIFPSSSIKKLDAYTIENEPIASIDLMERAATVLTKAITDRWNT
                     ETPVTIFAGPGNNGGDALAVARMMAEKGYKIEVFLFNTKGELSPDCQTNKELVEMMEEV
                     KFHEISTQFVPPVLTPDHLVIDGLFGSGLNKPLSGGFAAVVKYINSSPAMVVAIDIPSG
                     LMGEENTFNVKANIIRADVTFSLQLPKLAFLFAENTEFVGEWEVLDIQLSEDGIEEMET
                     NYEMLEIEQIRSLIKPRKQFAHKGNFGHALLIAGSKGMAGASVLAARACLRSGVGLLTV
                     HAPMCNNDILQTSIPEAIVETDINETCFAVPTDTDDYQAVGIGPGLGRNEETEAALLEQ
                     LEHCHTPVVVDADALNILANHRHALTHLPKGSILTPHPKELERLTGKCQDSYERLMKAC
                     ELARAAHVHIILKGAYSAIITPEGKCFFNPTGNPGMATGGSGDVLTGVILALLAQGYST
                     EEAAKIGTYIHGLAGDVAQKKQGMIGMIASDIITCLPTAWQLVSE"
     CDS             8593..9660
                     /locus_tag="ctg35_40"
                     /transl_table=11
                     /translation="MKKLIIAAGLLMTTSAYAQTEVLTGVTRGKDYGVVYSLPKTQIEL
                     EIKANKVNYTPGEFSKYADRYLRLTNVSADPEEYWELASVKVKSVGVPNSETTYFVKLK
                     DKTVAPLMELTEDGIVKTINVPYSNSSVGKKAAPAPAVLQKKANPREFLTEEILMASST
                     AKMAELVAKEIYNIRESKNALLRGQADNMPSDGAQLKIMLDNLNAQEEAMTQMFSGTCN
                     KEERTFTVRLTPDKEFNNEVAFRFSKKLGVVANNDLAGTPFYISLKDLKSVKMPQEDGK
                     KKKDLDGIAYNVPGQAMVTLTDGKKKLYEGELPITQFGVIEYLAPVLFNKNSTIKVYFD
                     PNTGGLLKVDREEGK"
     CDS             9698..9982
                     /locus_tag="ctg35_41"
                     /transl_table=11
                     /translation="MVGEGHAFDMIRRIKEGREASRLRRERANDKLKHLNRANEPYPLP
                     NTTPEEMERIIHDSEKKKEKDSNYFVWGTLIIMGVLIAIAVILWAVFIK"
     CDS             complement(10001..10351)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RRE-containing: PqqD_RRE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF05402"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg35_42"
                     /sec_met_domain="PqqD_RRE (E-value: 1.2e-10, bitscore:
                     32.8, seeds: 9, tool: rule-based-clusters)"
                     /sec_met_domain="PF05402 (E-value: 5.2e-17, bitscore: 53.6,
                     seeds: 461, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAAKEKINLLEVIPCRSEHITAEREGETIVLSFPRFKYPWMQRFL
                     VPKGMSKELHVKLEEHGTAVWELIDGKRNVREIIEKLADHFQNEEGYELRVSAYLSQMQ
                     KDGFIKLVIPVV"
     CDS             complement(10449..11837)
                     /gene_functions="transport (smcogs) SMCOG1106:major
                     facilitator transporter (Score: 92.3; E-value: 4e-28)"
                     /gene_kind="transport"
                     /locus_tag="ctg35_43"
                     /transl_table=11
                     /translation="MTEHLKQKLNDSAVLRWSVLALVAFTMLCGYFLTDVMSPLKPMLE
                     KELLWDSLDYGFFTSAYGWFNVFLLMLIFGGIILDKMGVRFTGMGACLLMVFGCGLKYY
                     AISTTFPEGAMLFGFKTQVTLAALGYAIFGVGVEIAGITVSKIIVKWFKGKEMALAMGL
                     EMATARIGTTLAMVLTVPLADFFGSTDESGTFHTNIPAPILFCLIMLCVGTIAFFLYTF
                     YDKKLDASLDAEGLEPEEPFRMKDIVYIITNKGFWLIALLCVLFYSAVFPFIKYAADLM
                     VQKYNVDPKLAGTIPGLLPIGAIILTPLFGSLYDRIGKGATLMIIGSVMLIFVHTMFAL
                     PILNIWWFATIIMIILGFAFSLVPSAMWPSVPKIIPEKQLGTAYALIFWVQNWGLMGVP
                     LLIGWVLNTYCKGPVVDGAQTYDYTLPMAIFALFGVLALIVALMLKAENKKKGYGLEEA
                     NIQK"
     CDS             complement(12087..12482)
                     /locus_tag="ctg35_44"
                     /transl_table=11
                     /translation="MYLLFVILMVIAALLMCFIVLIQNSKGGGLASGFSSSNAIMGVRK
                     TTDFLEKATWGLAIFMVVMSIATAYVVPRSAVAKDAVLEQAQKEQQTNPYNLPAGTAAP
                     QTEAPATNAPATETPAPATETPAPAAE"
     CDS             complement(12489..13262)
                     /locus_tag="ctg35_45"
                     /transl_table=11
                     /translation="MTSVNFQQWIQHPETLNRDTLYELRNLLARYPYFQSLRLLYLKNL
                     YILHDISFGGELRKAVLYIADRRQLFRLIEGDRYDVQARKKGVPLTEVLKDEPSVDRTL
                     ALIDAFLSTVPEEVTARTSFDYSMDYTSFLLEETPATEQPAEETPKLKGFELIDDFIEK
                     SESDSPLCMKPLREEMPSSPTSSDELTEEETMKEEEEDDSCFTETLAKIYVKQQRYSKA
                     LEIIKKLSLKYPKKNAYFADQIRFLEKLIINANSK"
     CDS             complement(13268..13795)
                     /locus_tag="ctg35_46"
                     /transl_table=11
                     /translation="MNWIKKIIRPLLLFGLPLVVIACTVSYKFNGSSINYDKVKTISIA
                     DFPIKSEYVYAPLATKFNEDLKDIFIRQTRLQLLKPSQNADLQIDGEITGYNQYNQAVS
                     ADGYSSETKLTITVNVRFVNNTNHAEDFEQQFSAFRTYDSTQLLTAVQDGLIAEMSKEI
                     TDQIFNATVANW"
     CDS             complement(13782..15023)
                     /gene_functions="regulatory (smcogs) SMCOG1112:sigma-54
                     dependent trancsriptional regulator (Score: 385.8; E-value:
                     4.8e-117)"
                     /gene_kind="regulatory"
                     /locus_tag="ctg35_47"
                     /transl_table=11
                     /translation="MTRAEIQQVKQRFGIIGNTEALSRAIDVAIQVAPTDLSVLITGES
                     GVGKESFPQIIHQYSRRKHGQYIAVNCGAIPEGTIDSELFGHEKGAFTGAIGERKGYFG
                     EADGGTIFLDEVGELPMPTQARLLRVLESGEFIKVGSSKVQKTDVRIVAATNVNLTQAI
                     AEGRFREDLYYRLNTVPIQIPPLRERGDDVLLLFRKFSADFAEKYRMPAIQLTEDAKKE
                     LLAYPWPGNVRQLKNITEQISIIETNREISAAILQNYLPAQNTQRLPALMGTRESKGFE
                     SEREILYSVLFDMRQEVAELKKMVHNLMAERAGQVGQVGQVGTVVTTPVVTTHQPSVPA
                     IIHTMQPAVCKDDDDIQDTEEYVEEPPLSLDEVEKEMIRKALERHHGKRKSAAKDLNIS
                     ERTLYRKIKEYELD"
     CDS             complement(15033..15215)
                     /locus_tag="ctg35_48"
                     /transl_table=11
                     /translation="MIAGKGVACEDSFRQAIYVAIDVFRNRQREKVARANPLRKQYYEK
                     RDDSDKLKLDTVDED"
ORIGIN
        1 acgatataca ggtaatcctt cgatattcaa tacaccgcgt ccgatacctt caaacggttc
       61 tcctgctttg ccgataccga gttcaagatg cgtaccttgt attttgtccg cgtcaaaacc
      121 accgatcgaa tgtcccgtac gaagagacac taaattaata aggtctacca acgtatcaat
      181 ctgatataaa ggaattccac gcatcaggcg gcggcgtaga gcttcggctg acggacggta
      241 acgcccgggg tctttgccac aacgtttata agcctcacgg gtagcaaaga taacaggttg
      301 acgtttgatg tcttccatct gcgtagtgga agtcagttgc ccagtaaaag cgttgatttc
      361 ctgccaaaga ccttcgctgt aagctgtatt cttcaccgca gcgtacacag cagctccggc
      421 aaaaaccggg catgtgtctt ttatttcttt agatactttt atttcaaaca taactaatca
      481 taaaccaatc atcagtgccc tgctctatta tggacgctaa ttattacttt cttttctaat
      541 cattattccc gacaatgtac gaccggaatc tatgcccagt ctacgtgcgg agaagaattc
      601 atcatgatga atataggaac aaattccagc cacttctatc tgctctgcag gcactccggc
      661 attcagtaat tcaatccgat ttgcttccca caaatcaata tgatactttc cggtttttct
      721 ctttttaaca gaaataagag acatatcgaa gccactttct ttaaaagctt cgtacacctc
      781 atcacccact tcaaatgatg cgagtgaaat gctcggaccg atacaagcta tcacatcttc
      841 gccctgcgtt ccgaacttct gattcatatg ctccagcaca ttgctgacaa tatgcttcac
      901 tgttcctttc catccggcat gaatggcagc caccacttgc aacttcttgt cgtacaacaa
      961 tacaggtacg caatccgcag ttgtaacgca aacgcaatat cccggtacat tggttatcaa
     1021 agcatcaata cctatcaaaa gatcctgtct tattccttcc gaagtatcaa agtaccattt
     1081 atcaatcacc atacttgcgg caccatgtcg ctgctcggct atgaataatt cttgtatttc
     1141 ccacttcatc aattgaaaca accaatgtcg gttacgaata agattcatag acgagtcgtt
     1201 cgtataaggc gagcaattga atgaggcgta agccccggaa ctaatacctc cgtgacgtgt
     1261 agtcacgaaa tgagcgactt caggatatgc cttgagtgac ttatacccct tcaactcttt
     1321 gcgttttgta agtgaaatca tttttcttcc caatcttctt cctcgtattc ataatcgata
     1381 tcatcgtcgt cgtcgacatc ttcctcatat tcataaacga tgtcttcatc ttcgcccatg
     1441 tctttgagtt cctgttgcag acgggtcacg tctttcggac ggtgaacgat gtcctctatc
     1501 ttattgcttt ccttgttcag ttcttcccaa aggatgtctt tcaacaccga gatgcccaaa
     1561 ccggaaacag aagatatgaa tacatgtgga atgccttccg gcaatgtagg ttcaatctcg
     1621 tccatcaact cctgatcgag catatcactc ttggtgacag ccaacacacg ttgcttgtcc
     1681 aacatttcag gattgaaggt acgcagttct ttcagcaaga cttcatattc tttacgaatg
     1741 tcgtcgctgt ctgccggaac cataaacagc agtaatgaat tacgctcgat atgacgcaag
     1801 aaacgcagtc ccaaaccttt tccctgactg gcaccttcga taatacccgg tatgtccgcc
     1861 atcacaaagg attttccacc gtgataggaa acgatgccca agttgggttc gagcgtagta
     1921 aacgggtaat cggcaatttt cggtttggca gccgaaatgg aagaaagcaa agttgacttt
     1981 cccgcattcg ggaaacctac cagaccgaca tcggcaagca gtttcagctc catgataacg
     2041 gtcatttcct gcatcggctc tcctggctgc gcaaaacgcg gagcctgacg ggtggccgtc
     2101 ttgaaatgcc agttaccctg accgccgcga ccgcctttga gcaagaccac ttcctgtccg
     2161 tcttctgtta cgtcacaaag atactcccct gtctcggcat tataaactac cgttccgcag
     2221 ggcacttcta ttattttatc cgcaccgtct tttccgaagc tacgtccttt gctccccgat
     2281 tcaccatgac cggccattgc atgacggtca tacttcaagt gcagcaatgt ccagtaatta
     2341 cggttaccgc gcaagatgat atgacctcct cttccaccat cgcccccgtc gggacctccg
     2401 ttaggacaat atttctcgcg cctcatgtgc gtagagcctc ttccgccctt acctgagcga
     2461 cagtatatct ttacgtaatc aacaaaattc gattcagcca tattttttta aagagttaaa
     2521 gtagtcagta gttagagcag ttaattagaa cactccggct actgacttat ttatttataa
     2581 tattgtatta ttacaattta tctactgctt cgcagatttc agcgaagata ccttccatag
     2641 tacccaagcc gttgatgtgt tggtatttct tttcgttctt gtaccagtcg atcagtggag
     2701 cagtctgtga atgatataca tgcagacgtt tcttgattgt ctcttcgtta tcatcagcac
     2761 gaccggaatc cttgccacgt ttaataagac gtaccatcag ttcttcttcc ggaacatcca
     2821 agtcaaccat tacagaaacg tcctgtcctc tttctgccaa cattttcttt aatgcttctg
     2881 cttgtgcaat tgttcttggg aaaccgtcga aaattacacc tttgctatct ttgaagctgt
     2941 cgaatacgct tgccagaata tcaatcatta attcatcagg aatcaattga ccttggtcga
     3001 tgtaaccttt agctgtttta cccagttctg tgccattctt gatttcagca cgcaatacat
     3061 ctcctgtcga gatgtgattg attccatact tttctacgat acgttcgctc tgtgttcctt
     3121 ttcctgaacc cggagcaccg aaaattacga tgttcaacat tttgttattt acaatttaac
     3181 gatttactat ttaccattta aactggtacc tatttaatat taatctacta ctgtataaat
     3241 atcgggataa ttacgtccga aaccatcata atccaacccg taacctacga taaagtcgtt
     3301 cggaatttcc atcgctacat attcaatgtt gaggtttacc ttgagctttt caggtttcac
     3361 caacagagaa gcgatatgga tagcttcggg attgcgtgta cctaatgttt cgagcagtcg
     3421 ctgcatcgtc agtcctgtgt ctacaatatc ttctacgatt acaatggtac gtccggcaat
     3481 gtcttcattc aggccgatta cctctttaat cactccggtg gaagtgatgc cctgataaga
     3541 cgccaacttc acaaatgaga tttcacaagg gatggtgatg tgcttcagta aatcagcggt
     3601 aaacatgaac gaaccgttca acacactaag gaaaagcgga ttcttacctg ccaaatcgcg
     3661 gttaatttcg ttcgctacgc gaatcacttc tttctgaatt tcttgttcct taatggaaac
     3721 ggtaaacaat ttgtctttta tctgaatggt atccataacc ggtaatttaa aaataacctt
     3781 gcaaaaatac gattttttat tctaccccgt gcatcatctt ctgtaatttc ttcgagagaa
     3841 ggaacagaat caacgaagca acaccggaca tcacgacgaa taccataaag aaatcataca
     3901 tggtagcaat ctgataacca aagattgact tcacttttcc ggcttccgga tagagtccgc
     3961 tcaacattcc cgcaaattta ttagctgtgg cagtagacag ataccagatt cccatcatca
     4021 aggaggcgaa acgcagcgga ctcaatttat ttaccattga aagtccgata ggcgacaaag
     4081 ctatttcacc catggtatga ataaagtaaa gtcctgtcag ccaaatcatg ctcactttca
     4141 ctccgggaac tgcatctttc actccgaaac agatgaaaag ataacctaaa gaaaggagta
     4201 acagaccaat cgcttgtttg gtaggagaag caggttccat ctttcgcttg ttcaggaaac
     4261 cccatacacc cggcatgata tatgccagga caactacaaa cagtggattg aaggattgaa
     4321 accatgaagc cggcatttcc caaccgaaaa tgtcacgatt cgtctgttcg gatgcgaaga
     4381 gagttaaaga agctcccgcc tgttcgtagg ctgcccagaa gaagatgaca aagaaggcta
     4441 ctatatagat aacgaaaata cggctgcgtt ctatttttgt caatgaaccg tctaacagga
     4501 tcagaacagg gaaaacaatg caggcggtaa aaatgccgat actcacccaa tcgccttcaa
     4561 atgcatagtt aaagaaggct attaaagcaa tggtaagaat tgtgattaca agggtgttac
     4621 gtactttggt acgtttgtcc atcttcgggt gtgagatatg gtcggccttg tcttctttct
     4681 tttcacgttt agcatcgggg ataataccaa tcggttctcc ggaaggagaa aaaagatatt
     4741 tattcttttg agtctcgaaa agaacaacgg tgaacagtgt catgattccg gctgcaagaa
     4801 atccccattt aaagtcatgc ggatcaccgg tatcacccag ataaccacaa atcaaaggag
     4861 cagcaaaaga gcctacattc actcccatat aaaaaatggt gtatgcagca tccagccgcc
     4921 tgtctccggg ttcgtagagc tgacctacca gagaagagac agtgggtttg aagcaaccat
     4981 tgcccaagat caggaagcct agtccgccat acatcatcca gtgggcaagg tttgtattat
     5041 ctaaagtgga agcactcata aacatcagga attgtccgac tgccatcatt accgctcccc
     5101 aaaacacgga gcgacggatt ccccaatatt tatcggcaat gtatccgcca atcaacgggg
     5161 ttaaataaac tagtccggta tagctgccgt agatggatgc tgccgcttct ttatcaaaca
     5221 ataatgcctg cgtcaggaaa agaataaaga tcgcacgcat accgtaataa ctgaaacgtt
     5281 ctgccgtgct tgtcgcgaaa atcaaataaa ggcctttcgg atgccctttc aatgcactca
     5341 tgaatttatg tgtttagtag tttatggggt gcaaaggtac agaaaaagta gattagatgc
     5401 ttctcttatc aaacagaata atagggggaa tagtaaaaac gagcataaaa aatcctactg
     5461 atccacttca ttactttttt agcagtgtaa ataataaagt ggagatccat cttaaatgta
     5521 ggttagctac caccttagcc aaaagtaaat tcgacatttt cgatactggc aaaaagcatt
     5581 ccttctcttt tcctcaaaaa gatcttgtct tctcgggcca gccaaccaat agcaagagct
     5641 acgtcttcaa acgtcaaact taattcacgg cacaaatcga acattgaaag ttcacctttt
     5701 tcatttaaga tgcgccatac tttcccggca ttcaagccaa tttttgtctt ttccatcatg
     5761 caaactttag aagattaaac aatccgttat ttagatttta attcattttc attgtgagca
     5821 ctggaaaatg atgtgatgca cattatctat ctccaaagat aacattttta tcggaaacgg
     5881 caaataatca aaggcttaat aaggggaact gcattaaaaa tttgtttaag aaggtatggc
     5941 gataaactaa acacaatttc catccgcccc tctacagaaa aagatttttc atttctcata
     6001 ttctcataaa taagaaacaa gtggcagtaa actaataaga tagactatga gaaatgattt
     6061 aaaaacaggc atttctcata gtttcttcgc aaaataaccc ggattttgct tcatttctca
     6121 tagtgtagtg tgccggaagc tgacattgaa taaataaaac tatgtattcc ttttgcttgc
     6181 ttccatacac agtgtcttag ttccacatat tgtgggaaaa gattccctaa ggcttgggaa
     6241 agtattcccg tattttgtgg gaaagtattc ccgtatattg aaggaaaact ttcccacaat
     6301 atatgggaca atcgagacca atgagcatct tcaagcaaaa agccactatt ttatctaaat
     6361 agtagcttca tttcctgata aaaataaggc aggctgaaag aaaaaaggaa gaacaaatgg
     6421 cttttgacta tgagaaatac cctgaaatac tatgagaata aggtggcttt tgagccaaaa
     6481 tatgggagaa cttatgagaa ataccgtttc gaaaaagtgt ttctcataag atatctattt
     6541 gattagcttt cgtttatcga aaaacaatga gaatatgaga aatgaaatga agaaatcttt
     6601 ggttcttctt caaattccgt gctacttatt tatgttcaat taccttattc atggctattc
     6661 cggagtactt taagatgcat atagtttgga taatttattt gctatttcta atatgccgat
     6721 atccctttat ccatcggcct ttcaatgagc tttactagca cggaatttga ttaagaacca
     6781 aatctttttc aggagaaata aaagtaagtt cataatggtg ctgcattgaa ttattttttg
     6841 gcggagttat tctaacactt aatagttcaa aagcagatat ttctctgacc caaagataga
     6901 actaatgatg aattaaaagt tgcaattatg gttttcttcc cacaacaaac gggaaaagtc
     6961 agaagaatca tgtacatttg taatccgaaa actaaaagaa catcgcaatg aaaatatttc
     7021 caagcagcag tatcaagaaa ttggacgctt ataccattga gaacgaacct attgcatcaa
     7081 tcgatctgat ggaacgtgca gcaaccgtat taacaaaagc catcacagac agatggaata
     7141 cggaaacgcc ggtcactatc tttgccggac cggggaataa tggcggagac gctctcgccg
     7201 tagcccgcat gatggctgaa aaaggatata aaatcgaggt atttctcttc aacacgaaag
     7261 gagaactttc acccgactgc caaaccaata aagaactggt agaaatgatg gaagaagtaa
     7321 aattccacga aatcagtacc caattcgtac ctcccgtcct gacgcccgac catctggtaa
     7381 tcgacggatt attcggttca ggcctgaaca aaccgttaag cggcggattc gctgccgtag
     7441 tgaaatacat caattcctcc cctgctatgg tagtagccat cgacattcct tccggactga
     7501 tgggagaaga aaacacattc aacgtaaaag ctaatattat ccgtgccgac gtaactttca
     7561 gtctgcaact gccgaagctc gcctttcttt tcgcagagaa cacggaattt gtcggagaat
     7621 gggaagtgct ggacatccaa ttaagcgaag acggtattga agagatggaa acgaactacg
     7681 aaatgttgga aatagagcaa atccgttcac tcatcaagcc acgcaaacag tttgcccaca
     7741 aggggaactt cggccatgca ctattgattg ccggttcaaa aggaatggca ggagcctctg
     7801 ttctcgctgc ccgcgcctgc ctccgttcgg gagtagggtt gctgactgtc catgcgccaa
     7861 tgtgcaacaa cgacatcttg cagacctcca tacccgaagc aatcgtagaa accgacatca
     7921 acgaaacctg ttttgccgta cctaccgaca cggacgacta tcaagcagtc ggcatcggcc
     7981 cagggctggg acgaaacgag gaaacggaag ctgctttatt ggagcaactg gaacattgcc
     8041 atactcctgt tgtggtggat gccgacgcac ttaatatcct cgccaaccac cgtcatgcac
     8101 ttacccacct gccgaagggt tccatcctca ccccgcatcc gaaagaactg gaacgtctga
     8161 ccggcaaatg ccaggactct tacgaacgtc tgatgaaggc ttgcgaattg gctcgtgccg
     8221 cccatgttca cattatttta aaaggagcct actccgccat tatcacccca gaaggtaaat
     8281 gtttcttcaa cccaaccgga aatccgggaa tggcaaccgg aggtagcggt gacgtactga
     8341 ccggagtaat cctggcactg cttgcccaag gttactcaac cgaagaagcc gctaaaatcg
     8401 gcacttacat tcacggattg gcgggcgatg tcgctcaaaa gaagcaagga atgatcggaa
     8461 tgatcgcaag cgatattatc acctgtctgc cgacagcatg gcaacttgta agcgaataaa
     8521 agttaagaac ttaccctttt ttcaataact tcattaactt tgttttcaaa accagttaaa
     8581 aaagaaccga atatgaaaaa gttgattata gcagcaggac tactaatgac aacgtccgcc
     8641 tatgcacaaa ccgaagtact gacaggggtt acccgaggaa aagactatgg agtggtttac
     8701 agtcttccca aaacccaaat agaacttgaa ataaaagcca acaaagtcaa ctatactcca
     8761 ggagaattca gcaaatatgc tgatcgttac ctgcgactga ccaacgtctc cgccgatcct
     8821 gaagagtact gggaactggc tagcgtaaaa gtgaaatccg taggtgtgcc caacagcgaa
     8881 actacgtatt tcgtaaaatt gaaggataag acagtagcac cgcttatgga actgacagag
     8941 gatggcattg tgaaaacgat caatgttcct tacagcaata gcagtgtagg caaaaaagct
     9001 gctcccgccc ccgcagtcct ccaaaagaaa gcgaatcctc gcgaattcct gaccgaagag
     9061 attctgatgg ctagctctac cgccaagatg gccgagctgg tggctaaaga aatctataac
     9121 atccgcgaaa gcaaaaatgc cttattgcgc ggacaggctg acaatatgcc ttcagacgga
     9181 gcacagctta agattatgct cgacaatctg aatgcacagg aagaagccat gacgcaaatg
     9241 ttctccggca cctgcaacaa agaagagaga acattcactg tccgccttac ccctgacaag
     9301 gaattcaaca atgaagttgc tttccgcttc tcgaagaagt taggtgtagt tgccaacaat
     9361 gatttggcag gaactccgtt ttatatcagt ctgaaagacc tgaaatcggt caagatgcca
     9421 caggaagatg gtaagaagaa gaaagatttg gatggaatcg cctacaacgt acccggacaa
     9481 gctatggtta cactgaccga cggtaaaaag aaactttacg aaggtgagct tcctattacc
     9541 caatttggtg tgatagaata tctggctccg gttttgttca acaagaattc taccatcaaa
     9601 gtttattttg atccgaatac gggaggattg ctcaaagtgg acagagaaga agggaaatag
     9661 aaaaacgaag gaagtgaact tctaaaaaac aaagaatatg gttggtgaag gacatgcatt
     9721 cgacatgata cgccgaataa aagagggacg ggaagcttcc cgcctacgtc gtgaacgtgc
     9781 taacgataag ttgaagcatc taaaccgtgc aaacgaacct tatccactac ccaacaccac
     9841 ccccgaagaa atggaacgta tcatccacga ctcggagaaa aagaaagaga aagacagcaa
     9901 ttattttgtt tggggaacgc ttattatcat gggagtcctg atagcaattg ccgtcatact
     9961 ttgggctgta tttatcaaat aaataataat aagttcctat ttatacgact ggtatcacca
    10021 gttttataaa tccatctttc tgcatttgag aaagataagc cgatacacgc aactcgtagc
    10081 cctcttcatt ttgaaagtgg tctgcgagtt tttctataat ctcacgaaca ttgcgttttc
    10141 catctatcag ttcccataca gctgtaccgt gttcttccaa tttcacatga agttctttcg
    10201 acattccttt tggcacaagg aagcgttgca tccacggata tttaaaacgg ggaaaggaga
    10261 gcacaattgt ctccccttcc ctttctgctg taatatgttc actgcgacag ggaatgacct
    10321 ctaacaggtt gattttctct ttggcagcca tacttcttat tttttatttc agagtattca
    10381 tactgatact cttctgttta caccttgata caaaattcct ttgttacttt aggtattgaa
    10441 tttcctagtt acttttggat attcgcctct tccaaaccgt atcccttctt cttgttctct
    10501 gccttcaaca tcaaagccac aatcagagca agcacaccaa agagagcaaa aatagccatc
    10561 ggcaacgtgt aatcataagt ctgtgcaccg tctactaccg gacctttgca ataagtattc
    10621 aacacccatc cgatcaacaa aggaacaccc atcaatcccc agttctgtac ccagaaaatc
    10681 aatgcatatg cggtacccaa ctgtttttcc ggaataatct tcggaacaga cggccacata
    10741 gctgaaggca ccaacgagaa ggcaaatccc aatataatca tgatgatagt agcaaaccac
    10801 catatattca gtataggcag agcaaacatc gtatgcacaa aaataagcat cactgatccg
    10861 attatcatca atgtggctcc cttaccgata cggtcataaa gcgagccgaa caacggagtc
    10921 aggataatcg caccaatcgg caacaatccg ggaatcgttc ccgccaactt cggatctacg
    10981 ttatacttct gcaccatcaa gtcggcagca tacttgataa aggggaatac agccgagtag
    11041 aacaatacac atagtaatgc aatcagccag aatcctttat tggtaatgat atacacaata
    11101 tctttcatac ggaacggctc ttccggctcc aatccttctg catccaaaga agcatccaac
    11161 ttcttatcat agaaagtata aaggaagaaa gcaatcgtac ccacgcacaa cataatcaga
    11221 caaaacaaaa tcggagcagg aatattggta tgaaatgtgc cactctcatc cgtagatccg
    11281 aaaaagtcgg ccaaaggaac cgtgagcacc attgccagag ttgttccgat acgtgccgta
    11341 gccatttcaa gtcccatagc caatgccatt tccttaccct tgaaccattt cacgataatt
    11401 ttggaaactg tgataccggc aatttccaca cctacaccga agatagcata ccccaatgca
    11461 gccagggtta cctgtgtttt gaatccgaag agcatggcac cttccggaaa agtagtagaa
    11521 atcgcatagt atttcaatcc acaaccaaac accatcaata agcaagctcc cattccggta
    11581 aaacgaactc ccatcttatc caaaatgata ccaccgaaaa tcagcatcaa taggaataca
    11641 ttaaaccacc cgtaagcact tgtgaagaaa ccataatcaa gactgtccca tagtagttct
    11701 ttctcaagca tgggctttag aggagacatt acgtcggtga ggaaatagcc gcatagcata
    11761 gtaaatgcga ccaatgctag aacactccat cggagtacgg cggagtcatt caatttctgt
    11821 ttcaaatgtt ctgtcattgt tatatttaaa aatagtagtt aataatcttc atacgaccaa
    11881 caaaggtagt taaatctcgt ttgtttctat caaaaagaga ttgtttttac aagaaaaagt
    11941 taagtgcgga ttacactgac cacgcggaag attgaaaatc cgtgtaatct gcgtaatccg
    12001 cacttaaata tcaaagaaat gcagcatccg tctgcacctt cccattaatg gttttacccc
    12061 aaagtcttac ctgacaacgg agtgaattac tctgctgcag gagcaggagt ttcagtagcc
    12121 ggtgccggag tttctgtagc aggtgcattg gtagcaggag cttcagtttg cggcgcagcc
    12181 gtacctgcgg gtaagttata cgggttagtc tgttgttctt tctgtgcctg ttccaacact
    12241 gcgtctttag caacagcaga gcgaggaact acataagcag tagcaatgct cattaccacc
    12301 atgaagatag ctaagcccca tgttgctttt tccagaaaat ctgtagtctt gcgtacgccc
    12361 atgatggcgt tagatgaaga gaaaccagaa gcaagtccgc ctccttttga gttctgaatc
    12421 agcacgatga aacacatcaa caaggctgca ataaccatta agataacgaa taataagtac
    12481 atttttagtt attttgaatt agcgttaata atcaatttct ccaaaaatct gatttggtct
    12541 gcaaagtaag catttttttt tggatatttc aagcttaatt ttttaattat ttcaagagct
    12601 tttgaatatc gttgctgttt aacatagatt tttgccaaag tttccgtaaa acagctgtca
    12661 tcttcctctt cttccttcat cgtttcttct tcggtaagtt cgtccgaaga ggttggcgaa
    12721 gatggcattt cttctcttaa aggtttcatg cagaggggag agtcgctctc gctcttttct
    12781 ataaagtcgt caatcagttc gaagcctttg agtttgggcg tttcttcagc cggctgttcc
    12841 gtggccggag tctcctccaa aaggaaagag gtgtaatcca tcgaatagtc gaaactggtc
    12901 cgggcagtca cctcttcggg tactgtggac aagaaagcgt cgatcaatgc taatgtgcgg
    12961 tctacggacg gttcgtcttt cagcacctcc gtgagaggta ctcccttttt ccgtgcctgc
    13021 acatcatagc ggtcaccttc aatcaaccgg aacaactgcc gtctgtctgc aatgtaaaga
    13081 actgctttcc gcagttctcc accgaaacta atatcatgga gaatatacag attcttcaga
    13141 tacagcagac gaagtgactg aaaatacgga tacctcgcaa gaagattgcg cagttcgtac
    13201 aaagtatccc tattcagcgt ctcgggatgc tgaatccatt gttgaaagtt aacagaagtc
    13261 atttatatta ccagtttgct acagttgcat taaaaatttg gtcggtgatc tctttagaca
    13321 tttcagcaat caatccgtcc tgtacggcag tcaacaactg ggtagagtcg taggtacgga
    13381 acgcagaaaa ctgttgttca aagtcttcgg catgattggt gttgttgaca aaacgcacat
    13441 tgacggtgat agtcaacttc gtctccgaag aataaccgtc ggcagatact gcctggttgt
    13501 actgattgta ccctgtgatt tctccgtcaa tctgcaagtc ggcattttga ctcggcttga
    13561 gcagttgcag acgggtctgc cggatgaaga tatctttcag gtcctcattg aatttggttg
    13621 ccaacggagc atatacatac tccgacttga tcgggaagtc ggctatcgaa atggtcttta
    13681 ccttatcata attgatagac gatccgttaa acttatagga aacagtgcac gcaatgacta
    13741 ccaacggcaa gccgaacagt agcaaagggc gtattatttt cttaatccaa ttcatattct
    13801 tttatttttc tataaagtgt acgctcggaa atattcaagt ccttggccgc actcttccgc
    13861 tttccgtgat gcctttcaag tgctttgcgt atcatttctt tttccacttc gtccagtgac
    13921 aaaggaggtt cttctacata ttcttccgtg tcttgtatgt cgtcatcatc cttgcaaacc
    13981 gcaggctgca tggtatgaat gatcgcaggt accgaaggct ggtgtgtcgt cactaccgga
    14041 gtagtaacca ccgttcccac ttgtcctacc tgccccacct gtccggcacg ttccgccatc
    14101 aggttgtgca ccatcttctt cagctccgcc acttcctggc gcatatcgaa cagaacagaa
    14161 taaagaatct cccgttcgct ctcaaagcct ttactctcac gcgttcccat cagcgcggga
    14221 agacgttgcg tattttgtgc aggaagataa ttctgcaaga tagcagcaga gatctccctg
    14281 ttggtttcaa tgatagatat ttgctcggtg atgttcttca actgacgaac gttgccgggc
    14341 cacgggtaag ccaataactc tttcttcgca tcctccgtca actggatagc aggcatccgg
    14401 tatttctctg caaagtctgc ggaaaactta cggaacaaca aaagtacatc gtcaccacgt
    14461 tcacgcaaag gcggtatttg gataggcacc gtattcaacc ggtaatataa atcttcacgg
    14521 aaacgtcctt ctgcaatcgc ttgtgtcaga ttgacattgg tagctgccac aatacgaaca
    14581 tccgtctttt gcactttgga cgaacctact tttataaact cgccactctc caacacacgg
    14641 agcaaacgcg cctgggtagg catcggcaac tcccctactt catcaaggaa aatagtacca
    14701 ccgtcggctt cgccaaagta ccctttccgt tcgccaatcg caccggtaaa cgcacccttc
    14761 tcatgcccga acagttcgga atcaatcgtg ccctccggaa tagcaccaca gttgacagca
    14821 atatactgtc catgcttcct ccggctatat tgatgaataa tctgcggaaa actttctttt
    14881 ccgactccac tttctccggt aatcagcaca gacaaatcgg taggagctac ctgaatggca
    14941 acatctatgg cgcgcgacaa tgcttcggta tttccaataa taccgaaacg ctgtttcact
    15001 tgttgtatct ctgctctcgt catcactcgt ttttaatctt cgtctactgt atccagcttc
    15061 agtttatcac tatcgtcacg tttctcgtaa tactgtttac gcaacggatt ggcacgagcc
    15121 actttttccc gctgacgatt acggaacaca tcgatggcaa catagattgc ctgacggaaa
    15181 gaatcttcac aagccactcc cttgcctgca atatcg
//
