LOCUS       c00048_gnlPro..        14054 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|JLGOJIDH_101.
ACCESSION   c00048_gnlPro..
VERSION     c00048_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2025-04-29 09:28:49
            Original ID  :: gnl|Prokka|JLGOJIDH_101
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 14054
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..14054
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[4161:10684]"
                     /cutoff="10000"
                     /detection_rule="(TPP_enzyme_C and not (PFL-like or
                     PFL_6_pcresol or PFL_9_tma or Gly_radical or Gly_430_pcre
                     or Gly_8-9_TMA or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and
                     minimum(2, [ALS_ss_C, AlaDh_PNT_C, Arginase, BKACE,
                     BcrAD_BadFG, Beta_elim_lyase, CPSase_L_D2, Cys_Met_Meta_PP,
                     ELFV_dehydrog, GRDB, Glu_syn_central, Glu_synthase,
                     Gly_reductase, HAAA1, HG2B1, HG2B2, HGD-D, HleuD1, HleuD2,
                     HleuS1, HleuS2, Homoserine_dh, ILVD_EDD, IlvC,
                     Lactoyl-CoA1, Lactoyl-CoA2, Lyase_aromatic, MAAL_C,
                     OKR_DC_1_5_lysine, OKR_DC_1_5_ornithine,
                     OKR_DC_1_7_arginine, OKR_DC_1_C, OTCace, PALP,
                     Proline_reductase, Sacchrp_dh_C, TPL, Thr_dehydrat_C, TnaA,
                     Urocanase]) and not (POR or POR_N or PFOR_II))"
                     /neighbourhood="10000"
                     /product="TPP_AA_metabolism"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      4162..10684
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(TPP_enzyme_C and not (PFL-like or
                     PFL_6_pcresol or PFL_9_tma or Gly_radical or Gly_430_pcre
                     or Gly_8-9_TMA or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and
                     minimum(2, [ALS_ss_C, AlaDh_PNT_C, Arginase, BKACE,
                     BcrAD_BadFG, Beta_elim_lyase, CPSase_L_D2, Cys_Met_Meta_PP,
                     ELFV_dehydrog, GRDB, Glu_syn_central, Glu_synthase,
                     Gly_reductase, HAAA1, HG2B1, HG2B2, HGD-D, HleuD1, HleuD2,
                     HleuS1, HleuS2, Homoserine_dh, ILVD_EDD, IlvC,
                     Lactoyl-CoA1, Lactoyl-CoA2, Lyase_aromatic, MAAL_C,
                     OKR_DC_1_5_lysine, OKR_DC_1_5_ornithine,
                     OKR_DC_1_7_arginine, OKR_DC_1_C, OTCace, PALP,
                     Proline_reductase, Sacchrp_dh_C, TPL, Thr_dehydrat_C, TnaA,
                     Urocanase]) and not (POR or POR_N or PFOR_II))"
                     /neighbourhood="10000"
                     /product="TPP_AA_metabolism"
                     /protocluster_number="1"
     cand_cluster    1..14054
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(TPP_enzyme_C and not (PFL-like or
                     PFL_6_pcresol or PFL_9_tma or Gly_radical or Gly_430_pcre
                     or Gly_8-9_TMA or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and
                     minimum(2, [ALS_ss_C, AlaDh_PNT_C, Arginase, BKACE,
                     BcrAD_BadFG, Beta_elim_lyase, CPSase_L_D2, Cys_Met_Meta_PP,
                     ELFV_dehydrog, GRDB, Glu_syn_central, Glu_synthase,
                     Gly_reductase, HAAA1, HG2B1, HG2B2, HGD-D, HleuD1, HleuD2,
                     HleuS1, HleuS2, Homoserine_dh, ILVD_EDD, IlvC,
                     Lactoyl-CoA1, Lactoyl-CoA2, Lyase_aromatic, MAAL_C,
                     OKR_DC_1_5_lysine, OKR_DC_1_5_ornithine,
                     OKR_DC_1_7_arginine, OKR_DC_1_C, OTCace, PALP,
                     Proline_reductase, Sacchrp_dh_C, TPL, Thr_dehydrat_C, TnaA,
                     Urocanase]) and not (POR or POR_N or PFOR_II))"
                     /kind="single"
                     /product="TPP_AA_metabolism"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..14054
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="TPP_AA_metabolism"
                     /region_number="1"
                     /rules="(TPP_enzyme_C and not (PFL-like or PFL_6_pcresol or
                     PFL_9_tma or Gly_radical or Gly_430_pcre or Gly_8-9_TMA or
                     PFL_acetate1 or PFL_acetate2 or Gly_radical_scatole or
                     PFL_proline or PFL_toluene) and minimum(2, [ALS_ss_C,
                     AlaDh_PNT_C, Arginase, BKACE, BcrAD_BadFG, Beta_elim_lyase,
                     CPSase_L_D2, Cys_Met_Meta_PP, ELFV_dehydrog, GRDB,
                     Glu_syn_central, Glu_synthase, Gly_reductase, HAAA1, HG2B1,
                     HG2B2, HGD-D, HleuD1, HleuD2, HleuS1, HleuS2,
                     Homoserine_dh, ILVD_EDD, IlvC, Lactoyl-CoA1, Lactoyl-CoA2,
                     Lyase_aromatic, MAAL_C, OKR_DC_1_5_lysine,
                     OKR_DC_1_5_ornithine, OKR_DC_1_7_arginine, OKR_DC_1_C,
                     OTCace, PALP, Proline_reductase, Sacchrp_dh_C, TPL,
                     Thr_dehydrat_C, TnaA, Urocanase]) and not (POR or POR_N or
                     PFOR_II))"
                     /tool="gutsmash"
     CDS             complement(168..1463)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Lyase_1"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg48_1"
                     /sec_met_domain="Lyase_1 (E-value: 4.8e-64, bitscore:
                     206.4, seeds: 17, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIDRYTSPEMKKIWSLETQYQCWLDVEIAADEAWSKLGHIPAEDV
                     EKIKKNAKFSVEGIAEIEAVTHHDVIAFTRDVSKSLGPERKWVHYGMTSTDVVDTAQGL
                     RLKKANDILRQDIDNFMDVLKELAEKYKYTVCMGRTHGIHAEPTTFGLKAARWYSEMKR
                     NKERFEHATKGVEAGKISGAVGTFAEIDPFVEEYVCKKLGLRPQEISTQVLPRDLHAEY
                     IATIALIGTSMEEMATEIRSLQRTEIHEVEEHFAKGQKGSSAMPHKRNPIGSENITGCA
                     RMLRGFMVPAYEDVSLWHERDISHSSAERMILPDATSLLDYMLRRFGRILKNLDVFPET
                     MKKNMDKTLGLIYSGRVLLKLVNSGMTREAAYDLIQPYTAKCWAEQIPFRPLLEDDPTI
                     QKQLTKEDLDDAFDYHWHLRHVDDIYKRLGLD"
     CDS             complement(1534..2688)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Hacid_dh_C"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Dala_Dala_lig_C"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg48_2"
                     /sec_met_domain="Hacid_dh_C (E-value: 9.4e-11, bitscore:
                     31.2, seeds: 144, tool: rule-based-clusters)"
                     /sec_met_domain="Dala_Dala_lig_C (E-value: 2.6e-13,
                     bitscore: 39.7, seeds: 13, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIKQKKVGSILNKFILQGSTIGIIGGGQLGQMMALDAKQTGMKVI
                     ILDPTPNCPAGQVADEQIVAPYADTKAIEKLADKADVLTYEFENVDLNALEDIQDRVYL
                     PQGTNLLYTTKNRLREKNFLRQAGVKTAPFMAVHTSAELKDAVKKIGYPAVLKTSEGGY
                     DGHGQEVLRNKDDLDKCASILATGDCILEGWVPFNRECSVMVGRNEDGEITAFPVSENI
                     HHDEILHLSIVPARISSELQQKAQKIAVQIAQAINLRGILGVEMFVTDDGEIYINELAP
                     RPHNSGHYSIEACNFSQFAIHNRAICNWPLPQVELLKPVVMVNVLGQHVNGVRQQIQKK
                     ANWHFHDYGKAEVRHNRKMGHVTILTDDIEATLAEIDNAGIWGA"
     CDS             complement(2651..3136)
                     /locus_tag="ctg48_3"
                     /transl_table=11
                     /translation="MSDISVVMGSKSDWPTVKETCDILDEFGVLYEKNVISAHRMPNEM
                     FAFAQNAVDNGVKVIIACAGGAAHLPGMIAANTPLPVIGIPGQTKALGGMDSLLSIVQM
                     PAGIPVATTAIGKAGAKNAALLALQILGITDKHIQQQIIEYRQAMHDQAKESGQYLE"
     CDS             complement(3290..4150)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) GHMP_kinases_C"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) GHMP_kinases_N"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg48_4"
                     /sec_met_domain="GHMP_kinases_C (E-value: 2.7e-10,
                     bitscore: 30.4, seeds: 112, tool: rule-based-clusters)"
                     /sec_met_domain="GHMP_kinases_N (E-value: 2.5e-15,
                     bitscore: 46.4, seeds: 447, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIIQAPASSANLGPGFDSIGIAVSLYLKLEVLGPSDNWQVDHQLG
                     KLPHDETNMIVTTALSVAPDLPPQHLRVVSEIPIAHGLGSSSSAIVAGIELANQLKNLN
                     LSKEEKVEIASQIEGHPDNVAPTILGGLVVGTHINGHFSAIEAPLFPYAFAAYIPPYNL
                     KTADARAALPYQLEYSQAVHASAVANTFVASLFAKNYNVAFKLMEADRFHEPYRKELVP
                     ELDQIRELGKKHGALATYLSGAGPTVMTVIDNDNYGLFEQAVHAAGLKGKVVRLHPDVE
                     GVKLI"
     CDS             complement(4162..5436)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: Homoserine_dh"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg48_5"
                     /sec_met_domain="Homoserine_dh (E-value: 1.4e-65, bitscore:
                     210.3, seeds: 932, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKNIKLGLLGLGTVGSGVLQMVQQNADKILDVTGCKLTVKTALVR
                     NLGNYNKYADETSLTTDFDEILNDDEIKIVVELMGGIHPAKEYITTLLKNHKNVVTANK
                     DLIASYGPELMTVAHENHCDLMFEASVAGGIPILRTIANSFTADKVTEVKGIVNGTTNY
                     ILTQMSQRGWSYHQALAQAQQLGFAESDPTNDVTGKDAAYKMIILSQFAFGTQLDIKDI
                     AVEGIDRLNDADVQQAASFGYVIKLLGITKLVNNGVFVEVGPVLIPRDHPLATINNEFN
                     AVMVTAQAVGDTLFYGRGAGGLPTANSVLSDITTVTKNIILGTNGNLFNNYQQPYIPAK
                     LADIKYPYYLSLTLPDVPGQMLKLTQMMTDINASFREITQTKDGKIAHIAIITHRMSKE
                     QLQTLLTKVANDQSINLSAAYKVMG"
     CDS             5543..7036
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: PALP"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg48_6"
                     /sec_met_domain="PALP (E-value: 2.7e-14, bitscore: 43.0,
                     seeds: 146, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDYRSTQGDLSTILKSPTAILQGLSPDGGLYVPLHFPQPTYNLAT
                     LISLPYQQLAATILNWFFDEFTSDQLLKNANTAYGSQWDNRLIAPLTPKHASNYYLELF
                     HGPTLAFKDIALQMLPQLVSRAAQNTQLEKQIVILTATSGDTGTASMRGFSNQKDTQVI
                     VFYPAGGVSPVQLRQMLGQPGSNLHAIAIKGNFDDAQTSVKHIFNDQAFNDRLAQNNNC
                     FSSANSMNIGRLIPQIVYYFAAYGQLVHTGGIQLGEKVNFTVPTGNFGDILAGYYAKKL
                     GLPINKLLCASNENNVLTDFFKSGKYERRRNFYLTNSPAMDILVSSNLERLLFDLYDES
                     CVTVAKLMKQLATDGHYQVDSTVLNKLQEQFVAGFATPDEVEAEIKRVYLNDGYVIDPH
                     TAVASYVTHQYQQQSHDTTPTVIVSTASPYKFPETVYHALTNQKVSQSGIPALQQLHDL
                     LGDQLSAGVQALVDQTPRQEKVINPADMETLISKILNLK"
     CDS             complement(7038..7415)
                     /locus_tag="ctg48_7"
                     /transl_table=11
                     /translation="LTLIAEIKFQEQHQQLTVIPRERSKNILAYLHKHYAEKVTINDSA
                     TAVNISPKECIRSFKKNIHQTPIEYLLNYRVEQAKKLLRHSELSITDIALRAGFSTSAY
                     FSKIFKERVGMTLREYRQRQG"
     CDS             complement(7449..7637)
                     /locus_tag="ctg48_8"
                     /transl_table=11
                     /translation="MIVTFPFLLGRYFNSAFYTKYLNPVLKNRSVEVLVIQESNPTGKK
                     FITLLHQLTDVADQPDK"
     CDS             7983..8144
                     /locus_tag="ctg48_9"
                     /transl_table=11
                     /translation="MFDELNDFAQLFTNPESPQQQDNYQRWIELAKIVNMTLYRLRKSA
                     NIIFPSDY"
     CDS             complement(8272..8988)
                     /locus_tag="ctg48_10"
                     /transl_table=11
                     /translation="MTTLYEHGTLAALMAGNFDGTITVGDLLKHGSMGIGTFTGLDGEV
                     VILNNEVYQAVSSGQVNHITDMDATMPFASVHFPAEQQDITLRNVNFAKLNNDFVKEHQ
                     LTNVFAFLQLSGEFKHVKIRIAPKQEKPYPTLLDVAQHQPEFAADNIAGTIIGYYAPEI
                     FGTITAAGWHLHFISDDRQFAGHLLAFDAPELTGSFEIFDNLEQHLPIHNQEFRASEVD
                     MATLRDGIAKSEGNAD"
     CDS             complement(9005..10684)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: TPP_enzyme_C"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg48_11"
                     /sec_met_domain="TPP_enzyme_C (E-value: 1.7e-44, bitscore:
                     141.1, seeds: 323, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MEEKLHGADVVIDSLRKHGVNLVFGIPGAKIDRLFEGLDGQDSED
                     APKLIVTRHEQNAAFMAQAYGRLTGKTGVAITTSGPGVGNLATGIMTANAEGDPMLAIG
                     GQVQRKDLHRATHQSTPSTEIMAPITQYSAEIQDPNNISEIMANAFEASQDARKGAAFV
                     SLPQDVDDAEVTEKPLPIYETPKMGPADPNDLQKLVELIKNSKMPVILVGQRGADEEIT
                     TALRKLLSDYLLPVVETYQAAGVVSRDLEQQSYFGRIGLFRNQVGDQLLQQSDLVIAVG
                     YDPIEYEPRNWNKEGNLRIVNLDTLPAQIDNHYTPIMQLVGNITTSLTELDKLLKGYEY
                     PLAATEQLAKYKQELDQDKKIQVPASNDASHPLAVVHAIQENVTDDMHVALDVGSHYIW
                     MARHFRCYQPRHLLISNGMQTLGVGLPWAMVAAMLYPEHKSVAVCGDGGFLFSGAELAT
                     AVQHHLNVVTIVWNDGGHYDMVKFQEEMKYSQAAGVKFGNVDIVKYAESFGATGLRVNK
                     PADLTKVISQAFNIDGPVVVDVPVDYSNNKELAANLIDSQLG"
     CDS             complement(10878..12539)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) FTHFS"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg48_12"
                     /sec_met_domain="FTHFS (E-value: 8.9e-261, bitscore: 855.6,
                     seeds: 408, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTDIEIADQATLEPITEIAEKLGLSEDAIEQYGKYKAKIDLNVKP
                     LPDKKHKLILVTSINPTPAGEGKSTVLIGLGDALNQLNYQTTIAMREPSMGPVFGIKGG
                     ATGGGYSQVVPMEDINLNFTGDLHALTSANNTLAALIDNYIMRDNAMNLDPRRIIWKRV
                     EDVNDRALRNVVTGLGGPMAGVPRETGFNITAASELMAILCLSTSLHDLKERISRIVVG
                     YTYDKEPVTVGQLNFQDAITIILKDALKPNLVQTLDHTPTIVHGGPFANIAHGCNSVLA
                     TQTALNLSDYTVTEAGFGADLGGEKFLDIKQRVLGKHPDAIVIVATVRALEYNGGAKLA
                     DLNDENLDALKKGMANLNRHIKNMQLYGLPIVVAINHFVSDTDKEIQMIKDDCAKQNVE
                     AILTDAWAKGGKGTHDLANKVVELADSPSEFTHIYDVQVDDLQTKLEKIAKQIYGAKEV
                     SFSRKAQNQLKRFAKYGWNDLPVCIAKTQYSFTDDQKQLGAPTDFTFHIRELVPKIGAG
                     FVVALAGNMMTMPGLPKEPAAVNMTIDDNGKITGLF"
     CDS             complement(12777..13811)
                     /locus_tag="ctg48_13"
                     /transl_table=11
                     /translation="MTNAWKHFIENVKLRRFTVLLLIIVVLWLMRSMMNLILFTFILTY
                     LVVSWVRLVQRWLPRMSTSLIVIVTYVLLIVLLYLGVTRYLPVLSRQVVKMVNSVVHFY
                     STHQATMIYRYVSHYISTATIMSQVRHGITIAVSTLTSIGAITVSFVMSLILSFFYTLE
                     LKQMNEFSHSFLDSDFGWFFQDIDYFGKKFVNTFGVVLEAQFFIAICNTVITTIGLLFM
                     RMPQIFALSLIVFIFSLVPVAGVIISTIPLAMVGYSVGGIRDVVYIIIMIIIIHTLEAY
                     VLNPKFMSSRTDLPIFYTFIVLLIGEHLFGTWGLIVGVPIFTFLLDVLGVKPIRGAKRI
                     KKEV"
ORIGIN
        1 cgaacttgtt atggttttgc caatcaaaaa tttttctttt taagaatcga ttgtattttt
       61 tcgtaaaaaa atacccccta cattttcgta ggaagtattt ttagtcaacc ataccagttg
      121 acagatatcc acttttttgt tcgtctagcc tcttaaacta acttaaatta gtctaatccc
      181 aaccttttat aaatgtcatc aacatggcgg aggtgccagt ggtaatcaaa ggcatcatca
      241 agatcttctt tagttaattg cttttgaatt gttgggtcat cttccaataa tggacggaac
      301 ggaatctgtt ctgcccagca cttagcggta tatggttgaa tcaaatcata agctgcttcc
      361 cgagtcattc cactgttaac caacttcaaa agaacccgac cactgtaaat taagcccaat
      421 gtcttatcca tattcttctt cattgtttca gggaatacat cgagattctt taagattcga
      481 ccaaaacgcc gcaacatgta atcaagtaat gaagttgcat ctggtaaaat cattcgctct
      541 gcactggaat gagaaatatc ccgttcatgc caaagcgaaa catcttcata agcaggcacc
      601 ataaagccac ggagcatccg cgcacaacca gtaatgtttt ctgagccaat tggattacgc
      661 ttatgtggca tagcagaaga tcctttttgt cccttggcaa agtgttcttc gacttcatgg
      721 atttccgttc gttgaagaga gcgaatctcg gttgccattt cttccatact tgttccaata
      781 agcgcaatgg tagcaatata ttcagcatgt aaatctcgcg gaagaacttg tgtggagatt
      841 tcttgaggac gtaagccaag ttttttgcag acatattcct caacaaatgg gtcaatttca
      901 gcaaaagttc ctactgcacc agaaatttta cccgcttcga cacccttagt agcatgttca
      961 aaacgttctt tattacgctt catttctgaa taccaccgag cagctttcaa gccaaaagtt
     1021 gttggttcag catggatacc atgtgttcgt cccatacaaa ctgtgtactt atatttttca
     1081 gctaattctt taaggacatc cataaagtta tcaatatctt gacgaaggat atcgttcgcc
     1141 ttttttaatc gcaagccttg tgcagtatca actacatctg tactcgtcat tccgtagtga
     1201 acccactttc gttcaggccc caatgattta gaaacatcac gggtaaaagc aatcacatca
     1261 tgatgagtca ctgcttcaat ctctgcaatt ccctccacag aaaacttggc attcttttta
     1321 atcttttcca catcttctgc tggaatatgc ccaagcttac tccacgcttc atcagcagca
     1381 atctcaacat ctaaccaaca ttggtattgt gtttctaagc tccaaatctt tttcatctct
     1441 ggactggtat aacgatcaat catcagtcaa aaatcctctc tatttttcta aatgtattat
     1501 cgcacaggaa aagcggttac gtaaagccga actttatgca ccccagatac ctgcattgtc
     1561 aatttctgct aaagtagctt caatatcatc agtcaagatt gtaacgtggc ccattttccg
     1621 gttatgacga acttctgctt tcccataatc atgaaaatgc caatttgcct ttttctgaat
     1681 ctgttgtcgg actccattaa catgctgacc taaaacattt accattacca ccggctttaa
     1741 taactctact tgcgggagtg gccagttaca aattgctcga ttatggatgg cgaactgtga
     1801 gaagttacaa gcttcaattg aataatgacc agaattgtga ggacgaggag caagctcatt
     1861 aatatagatc tctccatcat ctgttacaaa catttcaacc cctaaaatcc ctcgcaaatt
     1921 aatcgcttgg gcaatctgca ccgctatttt ttgcgccttt tgttgtaatt cagaagagat
     1981 tcttgctggg acaatgctta aatgtagaat ttcatcatgg tgaatatttt ctgaaacagg
     2041 aaaagccgtt atttctccat cttcattacg tccgaccatt actgaacatt cgcggttaaa
     2101 aggaacccag ccttctaaga tacagtcgcc agtggctaaa atagacgcac acttatcgag
     2161 gtcatcctta ttacgtaata cttcttgacc gtgtccgtca tatccccctt cactagtttt
     2221 caaaactgct gggtaaccga ttttctttac tgcatctttt aattcagcag aagtatgtac
     2281 tgccatgaaa ggtgctgttt ttacccctgc ctgacgtaag aaattctttt cccgtaaacg
     2341 atttttggtc gtgtaaagca aattagttcc ctggggaaga taaacgcgat cctgtatatc
     2401 ttccaaagcg tttaaatcaa cattttcaaa ttcgtaggtt aatacatccg ctttatcagc
     2461 taacttttca atcgctttag tatcggcata aggagcaaca atttgttcat cagcaacctg
     2521 ccccgctgga caatttggtg tcggatctaa aataataacc ttcatccccg tctgtttggc
     2581 atccaatgcc atcatctgtc ccaattggcc accaccaata atgccaatag ttgagccttg
     2641 tagaataaat ttattcaaga tactgcccac tttcttttgc ttgatcatgc atcgcctgtc
     2701 gatattcgat gatttgttgt tgaatatgct tatctgtgat cccaagaatt tgcaatgcta
     2761 ataacgctgc atttttagcg cctgcttttc caatcgcagt ggttgccacc ggaattcccg
     2821 ctggcatttg aacaattgat aaaagcgagt ccatgccacc aagagctttt gtctgtcctg
     2881 ggatcccaat tactggcagg ggggtatttg ccgcaatcat tccgggaaga tgggctgctc
     2941 ccccggcaca tgcaattatt actttgaccc cattatcaac cgcattttgc gcaaacgcga
     3001 acatttcatt tggcatccga tgagcagaaa tcacgttctt ttcatataaa acaccaaatt
     3061 catctaaaat atcacaagtt tctttaacag ttggccagtc tgatttactg cccattacta
     3121 cactaatatc actcataaca atgcctcctc aaatctgctt taaggatagc aaagattttt
     3181 ttataattca atgtaaaaat cgaacttaat aaagttaaaa cataaaatag ttcgttaaaa
     3241 ttcataaaaa agaaaaaagg ccgaatccat ttccagcctc tttcctaaat tatattagtt
     3301 taactccttc aacatctggg tgtaaacgga ctacttttcc ctttagcccc gcagcatgta
     3361 ctgcctgttc aaataatccg taattgtcat tatcgataac tgtcattact gttggtccgg
     3421 cgccgcttaa atatgttgct agtgctccat gtttttttcc taattcacga atttgatcta
     3481 attctggaac tagctctttg cgatatggtt catgaaagcg atctgcctcc attaatttaa
     3541 acgctacatt atagttttta gcaaacaaac tagcaacaaa ggtattagca accgcgctcg
     3601 catgaacagc ttgggaatat tctagttgat atggcaaggc agctcgcgca tcagctgttt
     3661 ttagattata aggcgggata tatgcagcaa aagcataggg gaataagggc gcttcaatcg
     3721 cagaaaaatg cccattaata tgtgtcccca ctactaatcc ccctagaata gtcggtgcga
     3781 cattatcagg atggccttca atctggctgg caatctcaac tttttcttcc ttgctaaggt
     3841 tcaggttctt aagctgattt gctaattcga ttccagcaac aattgcgctt gaactacttc
     3901 ctaatccatg tgctatcgga atttcactga ctacccgcag gtgctgtggc ggcaaatccg
     3961 gtgcaacact taatgccgtt gttacaatca tattcgtctc atcatgaggg agcttcccaa
     4021 gctggtgatc aacttgccag ttatcgcttg gaccaaggac ttctaatttt aaatacaaag
     4081 agactgcaat cccaatcgag tcaaatcccg gaccaagatt agcactggaa gcaggtgctt
     4141 gaataatcat tatacttcct cctatcccat cactttataa gccgccgaca agttaattga
     4201 ctgatcatta gccactttag ttagtaatgt ctgtaattgt tctttgctca tccggtgagt
     4261 aatgattgca atgtgcgcaa ttttgccatc ttttgtttgg gttatttcac gaaaactagc
     4321 attaatatcc gtcatcatct gggttagctt caacatttgc ccaggaacat ccggcaaggt
     4381 taacgataaa taatatggat attttatatc agcaagtttt gccggaatat aaggttgttg
     4441 gtaattatta aagagatttc cattagttcc caggataatg tttttcgtta ccgttgtaat
     4501 atcacttaac acactgttag cagttggcaa gccccctgca ccgcggccat agaagagcgt
     4561 atcaccgacc gcttgggctg taaccattac tgcattaaat tcattattga ttgttgctaa
     4621 aggatgatca cgggggatta acactgggcc aacttcgaca aatactccat tgttaaccag
     4681 cttggtaatc cctagtaatt taattacgta tccaaatgac gctgcttgtt gaacatcagc
     4741 gtcattcaat cggtcaatcc cttctaccgc aatgtcctta atatctagtt gagttccaaa
     4801 tgcaaattga cttaatataa tcatcttgta agccgcatcc ttacccgtca cgtcattggt
     4861 tggatcactc tctgcaaatc ccagctgttg tgcttgggca agtgcttggt ggtatgacca
     4921 tccccgctgg ctcatttgcg ttaagatgta attcgttgtt ccatttacaa ttccctttac
     4981 ttcagtaacc ttatctgccg taaagctatt agcaatcgtc cgcaaaatag gaatcccacc
     5041 agccacactc gcttcaaaca ttaagtcaca gtgattttca tgcgcgacag tcatcaattc
     5101 tgggccataa gacgcaatca aatccttgtt cgctgtgacc acgttcttat gattttttaa
     5161 taaggttgta atatattctt tagccggatg aataccaccc ataagttcaa cgacaatttt
     5221 tatttcatca tcattcaaga tttcatcaaa atcagttgtt aaagaagttt catcagcata
     5281 cttattatag ttaccaaggt ttcgaactaa agctgtttta actgttaact tgcacccagt
     5341 aacatcgaga attttatccg cattttgttg aaccatctgt aagactcctg acccgaccgt
     5401 acccagaccg agcagtccca gtttaatgtt tttcattttc ccacctcagt ttctcattgt
     5461 tttttcattt tcagcattgt accatagcat ataagaaaca tacaattaaa ataaaatcac
     5521 ctttgaaatt ggaggaatta tcatggacta ccgtagcact cagggagact tatcaacgat
     5581 tttaaaatca ccaactgcta tcttacaagg actttctcca gatggcggtc tttatgtacc
     5641 gcttcatttt cctcaaccaa cttataacct tgcaacctta atttcgttgc cgtaccaaca
     5701 acttgctgca actattctta actggttttt tgatgaattt acgagcgacc aactactgaa
     5761 aaatgcaaat accgcttatg gtagtcagtg ggataaccgt ttaattgccc cattaacgcc
     5821 caaacacgcc agcaattatt atcttgagct ttttcacggg ccgacactgg catttaagga
     5881 tatcgcctta caaatgttac cccaattagt gtcacgtgct gcacaaaaca cccaactaga
     5941 aaaacaaatc gttatcctta ccgcaacttc tggtgatact ggaacagcct caatgcgagg
     6001 gtttagcaat caaaaagaca cacaggtaat cgtcttctac cctgctggcg gggttagtcc
     6061 ggttcaatta cgccaaatgc tggggcagcc tggatccaac ctccacgcaa tcgcaattaa
     6121 gggtaatttt gatgatgccc aaacaagcgt taaacatatt ttcaacgatc aagcatttaa
     6181 tgaccgcctt gcgcaaaata ataactgctt ttcctcagct aattcaatga atatcgggcg
     6241 gcttatcccc caaattgtgt actattttgc tgcatacgga cagcttgttc atacaggcgg
     6301 gatccaacta ggggagaaag ttaatttcac cgtgccgact ggtaattttg gcgatatcct
     6361 cgctggttac tacgctaaaa aattaggctt accaattaat aagctcctgt gtgcttctaa
     6421 tgaaaacaat gtattgaccg actttttcaa gagcggaaaa tatgagcggc gacgcaactt
     6481 ttacctaact aactcaccag caatggatat tttagtatca agtaatcttg agcggctcct
     6541 ctttgatctt tatgatgaaa gctgcgtaac agttgctaaa ttaatgaagc aattagctac
     6601 tgacggtcac taccaggtag attccaccgt attaaataag cttcaggagc aatttgtggc
     6661 tggttttgcg accccagatg aagttgaagc cgaaattaaa cgagtatatt taaatgatgg
     6721 atatgttatt gacccgcata ctgcagtggc atcatatgta acacatcaat atcagcaaca
     6781 aagccatgac acaactccca cagttatcgt gtcaactgcc agtccatata aattccctga
     6841 aaccgtctac cacgcactaa ccaaccaaaa agttagtcaa agcgggattc ctgctcttca
     6901 acagttacat gatcttctgg gagatcagct tagcgctggt gtccaagcgt tagtagacca
     6961 aacgccgcgc caagaaaaag tcattaaccc agcagacatg gaaacattga taagtaaaat
     7021 tttaaactta aagtaagcta cccttgacgc tgccggtatt cccgtagtgt catccctacc
     7081 cgttccttaa atattttact aaaataggca ctcgtactaa atcccgcccg caaagcaata
     7141 tccgtgatcg aaagctccga atgccgcaat aatttctttg cctgctcaac ccggtaattt
     7201 aataagtatt caattggcgt ttggtgaatg tttttcttaa atgaccgaat acattctttg
     7261 ggactaatat tgaccgcagt tgcactatca ttaattgtta ccttttccgc atagtgtttg
     7321 tgcaaatacg ctaaaatatt tttgctgcgt tcacgtggga taaccgtcaa ttgctggtgt
     7381 tgttcttgaa acttaatttc agcaattagt gtcaaccaag cttgtaaaag gagattgcgg
     7441 atttaaaatt acttatcagg ctggtccgcc acatctgtta gctggtggag taaggtaatg
     7501 aattttttgc cggtcgggtt agattcttga atcaccaaaa cttcaactga acgatttttt
     7561 aaaacagggt ttaggtattt agtataaaaa gcactattga aatacctgcc aagcagaaat
     7621 ggaaatgtca caatcatgtc ctaatgctac cggtgggcac aagggatcag aaagttcttt
     7681 attatgatga catggtacaa atctacaaaa tggctaacca ggaaatctag cttatgttac
     7741 gattaggaat tattggaacc catactattt ttgaccagat gattcatgca gcgcaagata
     7801 ctgggaaata ttaacttact gttgtatatt cccgtaagct tagcaccgca aaagcatttg
     7861 gcaataaata taggcttcgc gacacgctaa taattgacag tattttcgat actaagaaag
     7921 tgacttatct taataatcag gggagtattc aagttatcaa taaccactac ttagataaca
     7981 ccatgtttga cgagttaaac gattttgcac aactctttac taaccccgaa tcgccacagc
     8041 agcaggataa ttatcaacga tggattgaac tagctaaaat tgttaatatg actctatacc
     8101 gtctccgtaa atctgcaaat attatttttc caagcgacta ctaattaatc aactcattaa
     8161 aaacgacaac ttaagatgat attttaaaaa tcacaaaaag ggttccagag ttcgttaccg
     8221 agcactggag ccctttttcg gcgttattta taccgccgct tcatttgttc tttagtctgc
     8281 atttccttct gatttagcaa ttccatcacg taaagttgcc atatcaactt cactcgcccg
     8341 aaattcttga ttatgaatcg gcagatgttg ttccaggtta tcaaaaattt caaagctacc
     8401 tgttaattct ggggcatcaa acgccagaag gtgaccagca aattgtcgat catcactgat
     8461 aaagtgaagg tgccatcccg ctgccgttat tgttccaaag atttctggcg catagtagcc
     8521 gatgattgtc cctgcgatat tatcagccgc aaattcaggc tggtgttgcg caacatcgag
     8581 taaagtcggg tatggctttt cttgcttcgg agcaatccga attttgacgt gcttaaactc
     8641 accactcaat tgtaagaatg caaaaacatt agtaagctga tgttctttaa caaaatcatt
     8701 attcagttta gcaaagttta cattccttaa tgttatatcc tgttgttcag caggaaaatg
     8761 gactgaagca aatggcattg tagcatccat atctgtaatg tggttaactt gaccacttga
     8821 aacggcctgg tacacttcat tattcaggat aacaacctca ccgtctaagc cagtaaaagt
     8881 cccaattccc atcgaaccat gttttaataa atcaccgaca gtaattgtgc catcaaaatt
     8941 tcctgccatc aacgcagcta acgttccgtg ttcatataat gttgtcataa tctttgttcc
     9001 cctcttagcc aagttgtgaa tcaatcaagt tggcagctaa ttctttattg ttactgtaat
     9061 caactggaac atctaccaca accgggccat caatattaaa ggcttggctg attaccttag
     9121 taaggtcagc cggcttattt actcgcagtc cagttgcacc aaaactctca gcatacttaa
     9181 cgatatcaac atttccaaat ttaacaccag ctgcttgcga atacttcatc tcttcctgga
     9241 atttaaccat gtcgtaatga ccgccatcat tccatacaat cgttacaaca ttaagatggt
     9301 gttggacggc tgtcgctaat tccgccccag agaagaggaa gcctccatcc ccgcaaactg
     9361 ccactgattt atgttcggga taaagcatcg ctgcaaccat cgcccatggc aagccaactc
     9421 ccagtgtttg catcccgtta ctaattaaca ggtgtcgtgg ttggtagcaa cggaaatgtc
     9481 gtgccatcca gatatagtgg gaacccacat ctagcgcaac gtgcatatca tcagtaacat
     9541 tttcttgaat tgcatgcaca accgctaacg gatgactggc atcattgctt gctggtactt
     9601 gaatcttttt atcttggtca agttcttgct tatacttagc gagttgctca gtggctgcaa
     9661 gaggatattc ataccccttt agtaacttat caagctcagt taagcttgta gtaatattac
     9721 caactagttg catgattggt gtatagtggt tatcaatttg cgctggcaag gtatcaaggt
     9781 ttacaattcg cagattcccc tccttgttcc agttccgtgg ttcatattca atcggatcat
     9841 aaccaacagc aataacaagg tcgctttgtt gaagaagctg atctcctact tgattacgga
     9901 aaaggccaat ccgtccaaag tatgactgtt gttctaagtc acgtgatact actccagccg
     9961 cttgatatgt ttcaacaaca ggcaataaat aatcacttaa taatttgcgg agagcagtcg
    10021 taatttcttc atccgcgccc cgttgaccga ctaagataac cggcatttta ctatttttaa
    10081 ttagttcgac tagtttttgt aagtcatttg gatcagcagg acccatctta ggtgtttcat
    10141 aaattggcaa cggcttttca gttacctcag catcatcaac atcttgtgga agactaacga
    10201 aagctgctcc cttacgtgca tcctgactcg cttcaaatgc attggccata atttctgaaa
    10261 tattattagg gtcttgaatt tcagcgctat attgcgtaat cggtgccata atttcagttg
    10321 aaggcgtgct ttggtgggtt gcgcggtgaa ggtctttccg ttgtacttgt cccccaatcg
    10381 ctaacattgg atctccttct gcgttggctg tcatgatccc agttgctaaa ttaccaactc
    10441 ctgggccaga tgtagtgatc gcgacccctg tttttccggt taagcgacca taagcttggg
    10501 ccataaacgc cgcattttgc tcatgccggg taacaattaa tttaggtgca tcttcactgt
    10561 cttgaccatc tagtccttca aacaaacgat caatcttcgc tccgggaata ccaaagacga
    10621 gattaacccc gtgttttctc aaactatcaa taacaacatc tgcgccatgt agtttctctt
    10681 ccattagcca ttcacctcta cctaattaaa cttataaaac gatatacctt tactgtagtc
    10741 cttattttat aatttcacaa gaaaacgatt aagttcacat agcagtatat caataacttc
    10801 aacccgctaa ccttgaaaat tttgtgaaaa aaacatcgat gtacgttatt gcacaatcga
    10861 tgttttgtgt tggttattta gaataatccg gtaattttac cattatcgtc aatcgtcatg
    10921 tttacagccg ctggttcttt agggaggcct ggcattgtca tcatattacc agctaatgcc
    10981 acgacaaagc cggcaccgat ctttggtacc aattcccgaa tatggaaagt aaagtcagtt
    11041 ggggcaccga gttgtttttg gtcatctgta aatgagtact gggtcttagc aatacatact
    11101 ggcaagtcat tccatccata cttagcaaat cgcttcaatt gattttgtgc tttacggcta
    11161 aatgatactt ctttagcacc ataaatctgc ttagcaatct tctctaactt agtttgaagg
    11221 tcatcaactt gaacgtcata gatatgagta aattcacttg gactatcagc aagttcgact
    11281 actttattag ccaaatcatg ggtaccttta ccgcccttag cccaagcatc agtcaaaatt
    11341 gcttcaacat tttgcttagc acagtcatcc ttaatcattt gaatttcttt atcggtatca
    11401 ctgacaaaat ggttgattgc aactacgatt ggtaacccat ataattgcat attcttaatg
    11461 tgacgattaa ggtttgccat tccttttttc agcgcatcaa gattttcatc atttaagtct
    11521 gcaagtttgg caccgccatt gtattctagc gctcggacag tcgctacgat gacaattgca
    11581 tctggatgct taccaagaac acgttgttta atatcaagga atttttcccc accaaggtca
    11641 gccccaaagc cagcttccgt cacagtatag tcagaaaggt taagggcagt ttgcgtcgcc
    11701 aaaacgctat tacacccatg ggcaatgttg gcaaatggtc ccccatgtac gattgttggc
    11761 gtatggtcta aagtttggac aaggttaggc tttaatgcat ctttcaagat aattgtaatt
    11821 gcatcctgaa aattaagctg gccaactgtg accggttctt tatcgtatgt atatcctact
    11881 acaattcgac taatccgttc tttcaagtca tgaagactag ttgatagaca taaaattgcc
    11941 atcaactcgg aagcagctgt gatgttaaag cctgtttcac gtggaacacc agccattgga
    12001 ccgccaagac cggtaactac atttcggaga gcacgatcgt taacgtcttc tacccgtttc
    12061 cagataattc gccgcggatc aaggttcatt gcattatcac gcataatata gttatcaatt
    12121 aaagcggcca aagtattatt agcacttgta agagcatgca agtcaccggt aaagttcagg
    12181 ttaatatctt ccattggaac aacctgacta tatccaccac cagttgcacc acctttgatt
    12241 ccaaaaacag gccccatcga tggttcacgc attgcaatcg ttgtctgata atttaactga
    12301 tttaatgcat cccctaagcc aatgaggaca gtcgacttcc cttcaccagc aggagtaggg
    12361 ttgatggacg taactaaaat tagtttatgt tttttatcag gtaaaggctt tacatttaaa
    12421 tcaattttgg ctttatactt accatattgt tcgattgcgt cttctgaaag tccgagtttc
    12481 tcggcaattt ctgtaattgg ttccagtgtc gcttggtctg caatctcaat gtctgtcatg
    12541 aatatcagct tcctttcttt agacctatct taatttcatt atacactaac tcaagacttt
    12601 ttcagcaatt ttgcaaaata agttcgattt ttattaactt tatccaatga attaacataa
    12661 attgttcgga tagcaaaaac tgggagaaaa ctttttctcc cagccttaac tgtttccatg
    12721 aatagtagca agacattatg gaaatagctt tgcgtcgcca caaggctaac tctcactcac
    12781 acttcttttt ttattctttt tgcaccgcga atgggcttta cgcctaatac atcaagtaag
    12841 aaggtaaaga ttggtacccc cacaatcaat ccccatgtac caaaaagatg ttcaccaatc
    12901 agtaatacga taaaagtata aaagattggt agatctgtcc ggctagacat aaacttagga
    12961 tttaagacgt aggcctccaa agtatggatg atgataatca tgatgataat gtaaaccaca
    13021 tcgcgaattc caccgactga gtaaccaacc atcgccaatg ggattgttga aataattact
    13081 ccagcaaccg gaaccaaact aaagataaac acaattaacg atagggcaaa aatctgcggc
    13141 atccgcataa ataataggcc aatcgtggta atcactgtat tgcaaatagc aataaaaaat
    13201 tgggcctcta atactacccc aaaagtattg acaaattttt taccaaaata atcaatatcc
    13261 tggaaaaacc agccaaaatc actatctaaa aagctatgag aaaattcatt catttgtttt
    13321 aattcaagcg tatagaaaaa gctcaagatt aaagacatta caaatgaaac ggtaattgca
    13381 ccaatacttg tcaaagtgct aaccgcgatt gttatcccat gccgaacctg actcataata
    13441 gtggcggtac ttatgtaatg gctgacataa cgatatatca tcgtcgcttg atgagtacta
    13501 tagaaatgaa ctactgaatt gaccatttta acaacttgcc gagataaaac tggtaaatag
    13561 cgggtcaccc ctaagtataa gagaacaatt aacaatacat aggtaacgat tacaattaaa
    13621 cttgtcgaca ttcgtggtaa ccatcgctgg acgagtctta cccaactaac aacaagataa
    13681 gtaagaataa atgtaaataa aattaaattc atcattgatc tcattagcca gagtacgaca
    13741 atgattaata ataagacagt gaaacgccgt agttttacat tctcaataaa atgcttccag
    13801 gcattcgtca ttcaatcatc tccctatttt tcctaccaat tagcatagta gcaagtttta
    13861 attttttcag caattagttt atcgctttct tatgaaatgt ttttattaat gttagtgtaa
    13921 gattttcata ggttggatga ataattcatc tggtcgtgga aatctttttt gtagaccaat
    13981 ttacttattt acaaaaaaag aaaagaccag tagcctttag tgtgtcgaat actaagcaaa
    14041 ggcaggtctt tcct
//
