LOCUS       gnlProkkaPNBNPLGJ_10   16186 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|PNBNPLGJ_10.
ACCESSION   gnlProkkaPNBNPLGJ_10
VERSION     gnlProkkaPNBNPLGJ_10
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2024-11-17 04:34:28
            Original ID  :: gnl|Prokka|PNBNPLGJ_10
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 16186
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     CDS             complement(1..333)
                     /locus_tag="ctg10_1"
                     /transl_table=11
                     /translation="MINLKIDPEFQSQIPPLTDDEFKQLEENILKEGKLISPLIVWGNT
                     LVDGHNRYEIVQEHPEISFSTMPLPFESREEVLAWICKNQLGRRNLTPEQKLFLIGKQY
                     EAEKSSH"
     protocluster    1..16186
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="True"
                     /core_location="[4706:6186]"
                     /cutoff="20000"
                     /detection_rule="(TIGR04223 or AgrB)"
                     /neighbourhood="10000"
                     /product="cyclic-lactone-autoinducer"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      4707..6186
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(TIGR04223 or AgrB)"
                     /neighbourhood="10000"
                     /product="cyclic-lactone-autoinducer"
                     /protocluster_number="1"
     cand_cluster    1..16186
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(TIGR04223 or AgrB)"
                     /kind="single"
                     /product="cyclic-lactone-autoinducer"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..16186
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="cyclic-lactone-autoinducer"
                     /region_number="1"
                     /rules="(TIGR04223 or AgrB)"
                     /tool="antismash"
     CDS             complement(677..1264)
                     /locus_tag="ctg10_2"
                     /transl_table=11
                     /translation="MSKKCYRFFGGLLNAQAKWLNKMSEKGYQLVRTGTLLYEFEKCKP
                     DEVTYCVEFIGEKSKENATDYADFLEDMGYKVFFKNINLNYSVGKVRWRPWAERGGRIA
                     TNTTTFNREILIVEKTNDGKPFELHTSYDDKEKYYRNLRNPWLFLLLLFALFAIIKHSI
                     VLGIFSLVSAIPSILYQLQIIDVRQKAKTWEK"
     CDS             complement(2564..3829)
                     /locus_tag="ctg10_3"
                     /transl_table=11
                     /translation="MLYYFVEFAGSFANIALLLLFIGRLFPKKEPVSRWFYAYVALLIA
                     GQCALSLFPDWVTQRTIYLLVGGFFLALLFYEVRPWQAVFASGAFFTLIALVEVLAMLL
                     IGLRIPDTDILMQAGAARLVYIVFSNLIQIPLVVLISHFFSRKGNALRILWMLPIIAIQ
                     IASIAVCYVAQYHAADDYFPDYMVGLMAVLLLINILIVFYVEALRENELEKFKVKFNEQ
                     QYNLQMEYYQQLKERQEEVRSLQHDVKKYILAMQAVAEHGDTEELHKIAQAATNVFERS
                     TNISAVGNPVVDALLNYYLRIAERNNIKVKLDVTIPEVLTISSLSLSIIIGNTFDNAIE
                     ACCDLPAEQRIIHLQLRKQYRSLFYRLENPYSDTVRSIRIGEYHGYGLKNINRIVQENH
                     GDFYTKKKDGVFTVQVRLNCEN"
     CDS             complement(3829..4527)
                     /locus_tag="ctg10_4"
                     /transl_table=11
                     /translation="MLKYHVAVCDDEKSDLDGIVQSVQQYDVQGCFDIETYMDGNELLS
                     ELQMQKKSFDLLLLDIEMPSNGFQLAQSLIQMEKHPLVVFVTKRHEYAVQGYGIAFRYL
                     VKPLDQTLFAAAMDAVLQELNSKHFTIEYDGVTMSLETSDIYFLESHGHKVLIHCKEQD
                     LTLRMSIPEALEQLPKRCFVSPHKSYLVNMEHIVYATETAVFLSSGHQLPISRRKRQEF
                     NQIFNAYLGR"
     CDS             4707..5294
                     /gene_functions="biosynthetic (rule-based-clusters)
                     cyclic-lactone-autoinducer: AgrB"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg10_5"
                     /sec_met_domain="AgrB (E-value: 1.7e-35, bitscore: 114.2,
                     seeds: 181, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MWERTLSQKSVRLFCEQKVIDEAKADAYVYGYELLISSVVSVLLV
                     VLIAVVCGDVRYALSFLIGFIPQRIYIGGYHATSHTRCYLAFSGLALICILLSKAIAAN
                     HLFRILTTVALLGISIFLSPIEAKNKPLSEKKRSSYKMVASVLSSIDFLLAIFNVLPYT
                     RHVVCYYLSKWVLIVFSTIPLVQQKFNANFCR"
     CDS             5307..5477
                     /locus_tag="ctg10_6"
                     /transl_table=11
                     /translation="MKKNKWVLLLIAFVAFLVLVYFIGACLNATAEALTIISLCIGILV
                     IYLVVKAIKSK"
     CDS             5496..6026
                     /locus_tag="ctg10_7"
                     /transl_table=11
                     /translation="MSTRKFIKKLTASLLFIAVVMSFGVQSAFAESNSPKATVKNNVVT
                     FSNLDQLKANEKLAIAVVDSNGDPATITIESVDNSISRVAKSSNSWKVSYKGVVIHAYF
                     YMTVTNNKVTNAWDYSITTLGSTYSDASLTYNSSSAKLTFTSNAYNGIASHTCWLKGTP
                     RGTNNEVDVTYSM"
     CDS             6040..6186
                     /gene_functions="biosynthetic (rule-based-clusters)
                     cyclic-lactone-autoinducer: TIGR04223"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg10_8"
                     /sec_met_domain="TIGR04223 (E-value: 1.4e-13, bitscore:
                     42.7, seeds: 127, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKQNSQKLIFFLSKITCAFAMAIAVLSVNSTCCFTAYQPDVPESL
                     DRN"
     CDS             6785..7351
                     /locus_tag="ctg10_9"
                     /transl_table=11
                     /translation="MTNKIKRLISILLVTVLFLLTIQPAFATGNKRKIDDYSIEELLNL
                     SVQEQENLGFYVLAEVPMRIPVSNTDGSRVVSYIDGTWRVLYTKANGLGFYMSGTTVGI
                     GPDLIKNVSGTDYYTSYSDNIERSCPFSTTALVPEQSIYNTTYTYDFYDVGTYLDCSVG
                     CYFGVVGSSKPIYWSATTQVTIPKL"
     CDS             7745..8101
                     /locus_tag="ctg10_10"
                     /transl_table=11
                     /translation="MEGKTDKISQKYLTEETITEYAKRWGKLLNENTSMRIWHANDVKS
                     VNIDYFDQRIISLVSRIPISVGELTADVLKAISAPVSDWYVMKRIEALLKKGVLQVVIP
                     NKIFYNTIVQLNEE"
     CDS             8300..9910
                     /locus_tag="ctg10_11"
                     /transl_table=11
                     /translation="MTAVIYARYSSDNQREESIEGQIRECTAYAEKNDITIVKHYIDRA
                     ISAKTDNRPQFQQMIKDSDKKLFDIVLVWKLDRFARNRYDSARYKTQLKKNGVKLMSAT
                     EIISEGPEGIILESVLEGYAEYYSADLAEKVVRGQTENILKGRCNGGRGTFGYTLDSER
                     KFHIDPLASPFVLESFTKYRDGLTMKEIRDWLNENGIKNPVGGAFTYNSVEHMLKNRRY
                     IGELKFRDVVVPDAIPPIVPLELFDDVQEKIAKNKKAPARRKAEDDYLLTTKLHCGCCG
                     ALMFGESGTSRTGEVHRYYKCATVKKKKGCKKKTVRKQWLEDLVVNQTMQLVRDDAAME
                     SIIAKVMELQNKENTNIPLYEKQLRDAESGIQNMLNAIQAGILTSSTKERLEQLEETKR
                     ELETRIAEEKLAKPKVTEEFIRFWLLRFRKLDMSLKDQRQALVDTFINAIYLYDDKVLI
                     TFNYKEGTQTVTFGEATEVASEGNGSDLDCFTAPRTAAQVMCSSPFYLFYRIHLAKAAQ
                     CLIIEAVPRCARVRLGCIG"
     CDS             9922..11283
                     /gene_functions="transport (smcogs) SMCOG1086:MATE efflux
                     family protein (Score: 286.5; E-value: 5.2e-87)"
                     /gene_kind="transport"
                     /locus_tag="ctg10_12"
                     /transl_table=11
                     /translation="MSSQTNTLTEGPLAKQIFLVSLPLALSNLLQVLFNMSDVAVVGRF
                     AGSTALGAVGSTSTLVTLFTGFLIGLSNGINVLVARFYGARHPKDVEKTVHSAAIISAV
                     AGVALLLIGLLGSPAMLRLLNTKEDLLPGAILYLRVYFLGMPALALYNFGNAVFSSIGD
                     TKKPLLYLSIAGALNIALNLFFVIVCDLSVVGVALASAISQCVSAFLILRALTRVQDCY
                     ALDVHKLQLDPVQAKSILALGVPAGLQNAIFAIANLFIQAGVNSFDSLMVKGNSAAANA
                     DGLIYDCMAAFYMACASFMSQNYGAGRPDRVKKSYFISLGYSFGVGLVLGAALFFCGPA
                     FLALFTTETAVIDAGMKRVAVMAFAYCVSAFMDCTIAASRGLGKTVVPTVIVVLGSCVF
                     RVIWVYTIFAHFHTIPALYLLYPCSWILTALAEIAYFASCYKRAMAIFRKPAAA"
     CDS             complement(11369..13282)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Pyr_redox_2"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) DAO"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg10_13"
                     /sec_met_domain="Pyr_redox_2 (E-value: 3.8e-09, bitscore:
                     28.2, seeds: 64, tool: rule-based-clusters)"
                     /sec_met_domain="DAO (E-value: 9.2e-13, bitscore: 40.5,
                     seeds: 521, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAKISRRNFMRGAAVGTMGAAAAGLLTACGNSASSTTGAPASSAA
                     SSAASSAVTKPSSPVDGKYVTKAMGHESWVHVATTFFDGKITACEVLSHEETIGIGNYA
                     CSRIPAAIVEHQSVNVPNLRGSSITSMAVKAAVKEAIELAGYNVDDFSKEVTIAASNEV
                     IEEEADVVIMGAGTSGLTCACRLLEAGYSVILVEKRDIPGGSMSMTYGGVATAGSKLQY
                     NYDVDGSFRSSAMGTLEGMMNFWQTMEKYHRTEFFNGEMPYMTKQYTVAGDLVDWMAGI
                     GIGFNTMGNYESATQYGASTPYLAPGCYEGGAGYAMMFMAQRVEKYEKGKIIYSTSVTD
                     LIKDESGRVVGFHAKGENGASYTLRGKAVCLASGGFAKNPEMLKKYSPDYADFFFNCAS
                     SMTGEGIQMGIDAGGYVECENRALPAFLSSYKSKFELAFIHQSAPGIMVNIKGDNIGNI
                     VSDNHYTMAKAKLNKDNGDTFYYVFDESSAVKLRDSESYGFNGYVAMFEKGEAVHYDSV
                     EKASEELNLPNLADAIEANNAAALAGEPDEFGRRNCPYIETRDGLWAIRVDPTFYLTTA
                     GLAIDTDCHVLTEDKKAIPGLYAAGDVCGSIEEKDAKQYGMGFDAALTYGYIMGETLKK
                     EI"
     CDS             13508..14425
                     /gene_functions="regulatory (smcogs) SMCOG1014:LysR family
                     transcriptional regulator (Score: 143.2; E-value: 1.7e-43)"
                     /gene_kind="regulatory"
                     /locus_tag="ctg10_14"
                     /transl_table=11
                     /translation="MTIYQLECFIAVAEELNFSAAAERLFTTQPAITYQINALEKETGL
                     HLFERTTRRTKLTAAGQSFYLDMVQMTSFGRQALKKAQDIQDADRSHLTVGLRQLFDYS
                     TFSSILAQFQHQFPNACVDVVPQDNRRPLEQLRSGQLDIGFFYATEHSRDRDISFTPLF
                     ALGYHVLMNPNSPLADRRALHLADLKGQSVVSSGAFDSFLSACQGPSLEQLAQVGVDCS
                     KITPSFEGALIMIQMGTAMSIVPCLSTAVIPGIVKVPLLDFPPVTVEIAAMRHAPRLEV
                     QSFIEIAKQKYAHHPDPLRMEALI"
     CDS             complement(14563..15579)
                     /locus_tag="ctg10_15"
                     /transl_table=11
                     /translation="MIFKPAQLGMAKLDPQELEADKKACRKIGPCGVGKKALYLNSFYI
                     DRRYYLPYGSITRVFKRVAMSSGGFSGKGVFASMAYLVVEYDGGKQKQCNFKDERDVDA
                     LLEVLAKEQPQLHLLSAAGEQALEKKAAEKAARKLPELSEDAQHSLTVLRRAKEYLDAK
                     PELSAELSAAQRRKRAQLQSKPVYRYVALAIFVLGVAAAAYGLYSVFSHTGSYGVYFAL
                     FGFAAIFLFSSYNMLPTAHNNNNAIMKRAEKAEAAMAEYVKHYPHGAFPVKSWYAHPIV
                     LKQMMDAVEEGRAVTVPEALDAVKARLKSLNADVEVEQEEYDEVVVIKALFLNHDYQ"
ORIGIN
        1 atgagaggat ttttccgctt catattgctt cccgatgagg aacagcttct gctccggggt
       61 gaggttgcgc cgccccaact gattcttgca gatccatgcg aggacttctt ctctgctttc
      121 aaacgggagc ggcatggtgg agaaagaaat ttcgggatgc tcctgaacga tttcataacg
      181 attgtggcca tcaacaaggg tgttacccca aacgatcaaa ggagaaatca gcttgccctc
      241 cttgaggata ttttcttcaa gctgcttaaa ttcatcatcg gtcagagggg gaatctggga
      301 ctgaaactcc gggtcgattt tcaagttgat catacgcaca ctcctttatc tctcctgctg
      361 cgtctgttct tcctcccgga aaaggacaca acattctgct ttgcggtttt cagtttgagc
      421 agttcttcct tggtttcctt gtactgctcg tagaactttg ccttttcgga tgccagctgc
      481 gcatactcga cttccagctt tttcgggctg ggcagcttcg tgatgttgtt tgccttgaga
      541 taggctgctg ccgtccggta tgctgtcagt tctgcacggt gctgttcttc aaaggctgcg
      601 gagcaatctt ttttgtattt ctataaataa caatcaagag ggtgacaaca aaagctgtca
      661 ccctcttgat tgttatttat ttttcccacg ttttagcttt ttgtcggaca tctataattt
      721 ggagctggta tagaatgctg ggaattgcag aaaccaatga aaaaataccc aagacaatag
      781 aatgcttgat aatcgcaaac agtgcaaata ggagcagcag gaatagccat gggttacgca
      841 aattgcggta gtatttttct ttatcgtcat aagaggtatg gagttcaaaa ggctttccat
      901 catttgtttt ttctacaatc aatatttctc gattaaaagt tgttgtgttt gtcgcaatac
      961 gaccgcccct ttctgcccat gggcgccaac gaacttttcc aacagaatag tttagattga
     1021 tgtttttgaa aaataccttg tagcccatat cctccaagaa atcagcgtag tccgttgcgt
     1081 tctcttttga tttttctccg ataaactcta cacaataggt cacttcatcg ggcttgcatt
     1141 tctcaaattc gtataaaagt gttcccgtcc gaacaagttg atagcctttt tcggacattt
     1201 tgtttaacca ttttgcctgt gcatttagca atccgccaaa aaatcgataa cattttttac
     1261 tcatactgca cctccaataa tttcacttgc gacgcttaca agttcattta gtcttgcaag
     1321 ctctttttct gcaatttctt ttccctgtgc tgtaatgtgg tattcttttt ttcttccctc
     1381 actatctcca taaggttcaa tccacttctt gtcctgcaaa gaatttaatg ctccatataa
     1441 agtgcctgcg cctagggaaa gccgtccgtc tgttttttct tcaataaact gcataacagc
     1501 gtatccgtgt tttggtgtat aaagagagag cagaatataa aaggtgactt ctgtaagcgc
     1561 gccacctttt gcattgtcgc gcatggtttg cctccttatt acggttactg taataaatat
     1621 atcactaacc gtaatattcg tcaagcggat tcaggaaaat tatttaatgg gtgtgtgaaa
     1681 gaagaacggt ctgctcttta tttgttttgt tgttcggcgt gtcgtggtgc tgggaattgc
     1741 taggggtcga ttgaacattc gttttggtca ttgtacctcc tgtctgttcg ataactcctc
     1801 ggtgaagtta tgtaagcacg acacgccgtt ccattcgtgc cgtaaggcac gaatgatgag
     1861 cagggtttgg ggtgggaccg cgtttgcgaa gcgcagcgca gcaatgaaag ccccagtggg
     1921 gcttttaagc ggcagcgcgg tctgcgacag cagatggagg ggcgttgccc cgacaagcgc
     1981 taccccaaca agatcacttc ggaaatgcag acgcattgca gaagtgaagt cccagtggag
     2041 cacaacattt tcaagaattg aaaatttgtg gccacgggac ggttcttgct ctccactgct
     2101 gcgctcaaaa cgtatttccg aaagttgttt ccgaattgtt aagacgcaaa aataagtaga
     2161 gagttccact gctcatatat gtgaatcgcc gtttgccccg aacgaagttc ctgcccctgt
     2221 tttgcagcgg cgttgactgg agagccggta tcacgttcgg tcggctcatg aaattttcaa
     2281 ggtgcaatct tccccggaaa agaaaaatac cgcccacgca gtacaggcga aggattttgt
     2341 cgggtgaaac agacggcaaa atgatcgggt gtgttgcggg gcggtaaatc ttcgcaggaa
     2401 ataaaaccgc acagaatcgt ttctttacag aaatctctgt ggatttgttg ggaatgataa
     2461 cataagtacg aatgcgtgtc aacacttcag gataatgaat acatcagatg aacgaaacac
     2521 acaaagtaca agcgaaagca aggctgcgtt ttagaagaat gttttaattt tcgcagttca
     2581 ggcggacttg gacggtaaac acaccgtcct tcttctttgt gtagaagtcg ccatggttct
     2641 cttgaacgat acgatttatg ttctttagtc cgtaaccgtg atactctccg atgcggatgc
     2701 tgcgaacggt atcgctgtat ggattctcaa gccggtaaaa gagactgcga tactgcttgc
     2761 gcagctgtag atgaatgatt cgctgttctg ctggcaagtc gcagcaggct tcaatggcat
     2821 tgtcaaatgt gtttccgatg atgatgctca aagacaacga tgagatcgtc agaacttcag
     2881 gaatcgtcac atccagtttg actttgatgt tattcctttc cgcaattcgt aagtaataat
     2941 tcaaaagagc atcaacaaca ggatttccga cagcagaaat atttgtggaa cgctcgaaaa
     3001 cattcgtggc ggcctgtgcg atcttgtgaa gttcttcggt atcaccgtgt tctgcaactg
     3061 cctgcatcgc cagaatgtat ttcttcacat catgctgtag agaacggact tcttcctgac
     3121 gttctttgag ctgctggtag tattccattt gaaggttgta ctgctgctca ttgaacttga
     3181 ctttgaattt ttctagctca ttttcccgga gagcttccac atagaacacg atcaggatgt
     3241 ttataaggag aagtacagcc ataaggccga ccatataatc agggaaataa tcatccgcag
     3301 catgatactg tgccacataa cagaccgcga tacttgcgat ttgaatcgca atgatcggca
     3361 acatccatag gatgcgcaga gcatttccct ttcggctgaa aaaatgtgaa atcagaacta
     3421 cgagtggaat ttgaatcagg tttgaaaaaa caatatagac caaccgtgct gccccagcct
     3481 gcattagaat gtcggtatcc gggatacgca gcccaatcag aagcattgca agcacttcca
     3541 ccaaagcaat cagtgtgaag aaagctccgc ttgcaaaaac cgcctgccac ggtcgaacct
     3601 catagaacag caatgcaagg aaaaatccgc caactaaaag atagatcgtg cgctgcgtca
     3661 cccaatccgg gaataaactc aaagcacact gcccagcaat caagagtgca acataggcat
     3721 agaaccacct tgagacgggc tcctttttgg gaaacagccg accgataaaa agcagcaaca
     3781 gggcaatgtt ggcaaagctc cctgcaaact caacgaaata ataaagcatc atcttcccaa
     3841 ataagcgttg aagatctgat tgaactcctg acgcttcctc ctgctgatcg gcagctgatg
     3901 tccgctggaa agaaaaacag cggtttccgt agcgtaaaca atgtgttcca tgttgacgag
     3961 ataacttttg tgtggtgaca caaagcaccg tttgggaagc tgctccaagg cttcaggaat
     4021 gctcattcgc aatgtaaggt cttgctcctt gcagtgaatc agaactttat gtccgtggct
     4081 ttccagaaag taaatgtccg atgtttccaa ggacatggta acaccatcgt attcgatcgt
     4141 gaaatgtttg gagttcagtt cctgaaggac ggcatccatt gccgcagcga acagcgtctg
     4201 atccaaaggt ttgacaaggt agcggaatgc aatgccatat ccctgcacag cgtactcatg
     4261 ccgcttcgtg acaaatacca ccaaaggatg cttctccatc tgaatcaaag actgcgccag
     4321 ctgaaaaccg ttggatggca tctcgatatc gagaagaagc agatcaaagg atttcttctg
     4381 catttgcaat tcgctcagaa gttcgtttcc atccatgtaa gtttcaatgt caaagcagcc
     4441 ttgcacatcg tactgctgga cgctttgaac aatgccatca aggtctgatt tctcatcatc
     4501 gcagactgca acgtggtact tcagcatttc gacaacctcc acaaaataat gtcctgctac
     4561 tattatagac tgtgcaaagg ctccttacaa gtagcctgac ctaccacttt tgtcaccaga
     4621 acgaccagtt ttgccaaacc tcttgatttt gctgaaattt atgatacagt gaagcaaaaa
     4681 tcagaagata aggtggcgca actgcaatgt gggaacgcac gctgtctcaa aaatcagtcc
     4741 gtcttttctg cgagcaaaaa gtgatagatg aagcaaaggc ggatgcgtat gtctatgggt
     4801 acgagttgct catatcatct gttgtgagcg ttctgcttgt tgttttaatc gctgttgtgt
     4861 gtggtgatgt gcggtacgca ctttcatttt tgattgggtt tatcccacag cgaatctaca
     4921 ttggcggata ccatgcaaca tcgcacacca gatgctattt ggcattctcc ggactggcac
     4981 ttatctgcat tttgctaagt aaggcaatcg cagcaaatca ccttttccgt atcctgacaa
     5041 cagtagctct tttgggcatc tctatctttc tctcacctat cgaagcaaag aataagcctt
     5101 taagtgaaaa gaagcggtca agttacaaga tggtcgcatc tgttctttcg tcaatagatt
     5161 tcctgcttgc catttttaat gtgcttccgt atacacgtca tgtagtttgc tactatctct
     5221 ccaaatgggt attgattgta ttctcaacaa ttcctttggt tcaacaaaaa tttaatgcca
     5281 acttttgtag atagggaggt gataacatga aaaaaaacaa atgggtgctg cttcttatcg
     5341 cttttgttgc atttttggta ttggtttatt ttattggtgc ttgccttaat gcaacggcag
     5401 aggcattgac aattatttcg ctctgcatcg gcatactggt catttattta gtcgtaaaag
     5461 caatcaaatc aaaataagga aaggaaaatg tgatcatgag tacaagaaaa ttcatcaaaa
     5521 aacttacggc gagtctgctt tttattgcgg ttgtaatgtc gtttggcgtt cagtctgcct
     5581 tcgctgaatc gaattcaccg aaagctaccg ttaagaacaa tgttgttact tttagcaatc
     5641 tcgatcaact gaaggcaaac gagaagctcg caattgcggt agttgacagt aatggtgatc
     5701 cagcaactat tactatcgag tcagtggaca attcaatttc tcgtgtagcg aaatcgtcga
     5761 attcttggaa ggtttcgtat aagggagtgg tgattcatgc atatttttat atgacagtga
     5821 cgaataacaa agtcacaaat gcatgggact attcgattac aactttgggt tccacatata
     5881 gtgatgcaag tttgacgtat aactccagtt cggcaaaact cacctttacc agtaacgctt
     5941 ataatggtat tgcttctcat acttgctggc tgaagggaac tcctcgcgga acaaacaatg
     6001 aagtcgatgt aacgtattct atgtaatgtg gaggacaata tgaaacagaa ttcacaaaaa
     6061 ctgatttttt tcctgagtaa aattacatgt gcttttgcaa tggcgattgc agtcttaagt
     6121 gtgaatagca cctgctgctt tacagcgtat cagccggatg tccctgaatc gcttgatcgc
     6181 aactaaactc atatgataga cattacccat tgctatcatg atattttgta ttcgtatgat
     6241 tccggtggac accttatgga tactacaaaa tcgtaccatc aagctgtggg aggctaagaa
     6301 tgaaaaaagg caaaagcaac ttttttctta ttgctccttt tgccctttgg ggctgcattt
     6361 cagtatggac tagtaatctt gtccgattga cagataaaag cgcagtacct tatgcttggg
     6421 cttctttgtt tttctcatat ggaatcgtag cagtgcatta tatccaagtg gcagtatcct
     6481 ccaaaggctg taacaatgcc gaaaacgaaa aaattgcatg ggttcagctt gggctttcaa
     6541 ctttgttctt gatagtagct gttgttctag ctattcaatg aaggaaagca aagtaatcac
     6601 ccaaagcagt gtaaggtcac aatattttct attccagcag tattctagta gtttcagcat
     6661 ttgtatggtt cacatttatt tgccgaggag tatacacctg aaggggaaaa tttaatgaag
     6721 gtgattccaa tggagcttta gtgtattgag tgaagaaaaa aaataaatta ggaggcagta
     6781 tactatgact aacaaaatca aacggctgat ttccattcta ttggtcacgg ttttatttct
     6841 cctgaccatt cagccagcat ttgcaactgg aaataagaga aagatcgatg attattcgat
     6901 agaagaactt ctcaatcttt ctgtgcaaga acaagagaat ctcggatttt atgttttggc
     6961 cgaggttcca atgcgcattc ctgtttctaa tacagacggc tcaagagttg tatcgtatat
     7021 tgatggaaca tggagagttc tttatacaaa ggccaatgga ttgggctttt atatgagtgg
     7081 aactaccgtc ggtattggcc cggatttaat aaaaaatgtt tcaggaacgg attactacac
     7141 gagctattcc gataacatcg aacgaagctg cccattttca acgacagcac tagttccaga
     7201 acaaagtata tataatacaa cctatacata tgacttctat gatgttggaa cttatcttga
     7261 ttgcagcgtt gggtgttatt ttggagtggt tggctcaagc aaaccaatct attggagtgc
     7321 aactacacaa gttaccatcc cgaaattatg attttgacca gctatggatg aaattgtttt
     7381 tgaacccagt gatgtcaata tgttagcagc tttaggcatc gtcgaaagtg taaagttgtt
     7441 tccgtttatg ttatcaatgg gagaacttca atatgcttgc gattcagaat atcgttgcaa
     7501 acaattcgtg aattgccttt cagaatatta tcctgacagc caaattgaag ctagacaact
     7561 gtggtcgaaa tatcatggta cagcgaatgc ggttcaatgt gatatgataa atcataagcc
     7621 actgcgtgtt tgggtcagga gttctgccga ttgttggtgc ggcatttatt atatttgtta
     7681 ctatgcagca aagtatggta caaatagaat tttgcttgca tccagagaag gtctgaaaga
     7741 atttatggaa gggaaaaccg ataagatctc acaaaagtat ttgacggaag aaactattac
     7801 tgagtatgcc aaaagatggg gaaagctatt aaacgaaaac acctccatgc gtatttggca
     7861 tgcgaacgat gttaaaagcg ttaacataga ttatttcgac cagagaatta ttagtttagt
     7921 atcgagaatt cctatttcgg ttggtgaact taccgcagac gtattaaaag cgatttctgc
     7981 tccggtaagt gactggtatg tcatgaaacg catagaagca cttttgaaaa agggtgttct
     8041 tcaagtcgtt attccaaaca aaatctttta taataccatc gtccagctaa acgaagaata
     8101 aaggaatccg agcaagtcgg cccaacagtc acctcatttc aacgagaggg gtggctgttg
     8161 ggtcaattgt tcaaaaagaa aaactgaaga taataaaaag tcttgatttc tccatcaaaa
     8221 catggtatat acattatacg aaacaatgct ttgaaagaac gctccaccgt tcaatgatgt
     8281 agaatgagag gtgtccgcca tgactgccgt gatctacgcc cgctattcca gtgacaacca
     8341 gcgcgaagaa tccattgaag gccagatccg tgaatgcacg gcctatgccg aaaagaatga
     8401 catcaccatt gtcaagcact acattgaccg tgccatctct gccaagacgg ataaccgccc
     8461 tcaattccag cagatgatca aggacagcga caagaagctg tttgacattg ttctggtctg
     8521 gaaacttgac cgttttgccc ggaaccgcta tgacagtgcc cggtacaaga cccagctgaa
     8581 gaagaacggt gtcaagctca tgtcggctac ggagatcatt tcagaagggc cggagggtat
     8641 cattctggaa tcggtgctgg agggctatgc ggaatactac tccgctgacc ttgccgaaaa
     8701 ggttgtccgt ggacagacag agaacatcct gaaaggacgc tgcaacggtg gtcgtggaac
     8761 atttggatat acgctggatt ccgagcggaa atttcacatc gacccgcttg catccccttt
     8821 cgtactggaa tcgttcacga agtatcggga tggcctcacg atgaaagaga ttcgggactg
     8881 gctgaacgaa aatggcatca agaacccggt cggcggtgcg ttcacctata acagtgtcga
     8941 acatatgctc aagaatcggc ggtacatcgg ggagttgaaa ttccgggatg tggtcgtgcc
     9001 ggatgcgatc ccgcccatcg tgccactgga actgttcgat gatgtgcagg aaaagattgc
     9061 caaaaacaag aaagcccctg cccggagaaa ggcagaggac gattacctgc tgaccaccaa
     9121 gctgcactgt ggctgctgcg gtgcgctgat gtttggcgaa agcggtacaa gccggacggg
     9181 agaagtccac cgctactata aatgtgccac ggtcaaaaag aagaagggct gcaagaagaa
     9241 aaccgtccgc aaacagtggc tcgaagatct ggtggtcaac cagaccatgc agcttgtccg
     9301 ggacgatgcc gctatggaat ccatcattgc caaggtgatg gaactgcaaa acaaggagaa
     9361 caccaacatt cccctctatg agaaacagct tcgggatgcg gaatccggta tccagaatat
     9421 gctgaacgcg atacaggctg gtattctgac cagctccacc aaggagcggc tggagcagct
     9481 ggaagaaacc aagcgtgagc ttgaaacccg cattgcggaa gagaagctgg caaagcccaa
     9541 ggtcacggag gagttcatcc ggttctggct gctgcggttc cgtaagctgg atatgagcct
     9601 gaaagaccag cggcaggcgc tggtggatac cttcatcaat gcgatttacc tgtatgatga
     9661 taaggttttg ataaccttca actataaaga aggaacacag accgtcacct ttggagaagc
     9721 gacagaagtt gcatccgagg gaaatggttc ggatttggat tgctttactg caccaaggac
     9781 tgctgcacag gttatgtgca gcagtccttt ttatttattt tatcgaatcc atcttgcaaa
     9841 agcggcgcag tgccttataa tagaggctgt gccccggtgt gcgcgggtac ggttaggatg
     9901 tataggataa aggaaaaaag tatgagttct caaacgaata cgctgacgga aggccctctg
     9961 gccaagcaga tctttctggt cagtctgccg ttggcgcttt ccaacctgct gcaggtgctg
    10021 ttcaatatgt cggacgtggc ggtggtgggg cgctttgccg ggtctacggc gctgggtgct
    10081 gtgggctcca ccagcaccct ggtgaccctg ttcaccggct ttctcattgg tctgagcaac
    10141 ggcatcaacg tgctggtggc gcgtttttac ggcgcgcgcc accccaagga cgtggaaaag
    10201 accgtccact cggcggccat catcagcgcc gttgccggtg tggcgctgct gctcatcggc
    10261 ctgctgggct cccccgctat gctgcggctg ctgaacacca aagaggatct gctgcccggc
    10321 gcgattttgt atctgcgggt gtattttctg ggtatgccgg cgctggcgct gtacaacttc
    10381 ggcaacgcgg tgttcagctc catcggcgac accaaaaagc cgctgctcta cctttctatt
    10441 gccggtgcac tgaacattgc gctgaacctg ttctttgtca tcgtgtgcga tttgagcgtg
    10501 gtgggcgtgg cgctggccag cgccatcagc cagtgcgttt ccgcgtttct gatcctgcgg
    10561 gcgctgaccc gggtgcagga ctgctacgcg ctggacgtac ataaattaca gctggacccg
    10621 gtgcaggcca agagcatcct tgcgctgggc gtacctgccg gattgcagaa tgctattttt
    10681 gccattgcca acctgttcat tcaggcgggc gtcaactcct ttgactcttt gatggtcaag
    10741 ggcaacagcg ccgccgccaa cgcggatggg ctgatctacg actgcatggc ggccttctac
    10801 atggcctgcg ccagctttat gagccagaac tacggcgcgg gacggcctga ccgggtgaag
    10861 aagagctact tcatcagtct gggctactcc ttcggcgtgg ggcttgtgct gggcgcggcg
    10921 ctgttcttct gcggaccggc cttccttgcg ctgttcacta ccgaaaccgc cgttattgat
    10981 gccggcatga agcgggtggc tgtgatggcc tttgcctact gcgtctccgc ctttatggac
    11041 tgcaccatcg ccgcctcccg cgggctgggc aagacggtgg tgcccaccgt catcgtggtg
    11101 ctgggctcct gcgtattccg ggtgatctgg gtgtacacca tctttgccca cttccacacc
    11161 atcccggcgc tgtacctgct gtatccgtgc agctggatac tgaccgcact ggcggagatc
    11221 gcctattttg ccagctgcta caagcgtgca atggccatct tccgcaagcc cgcggcggcg
    11281 taaaaggaaa tatgatataa aaagggctgc tgcacggttt gtgcagcagc cctttattta
    11341 tgcttttgtc agggggtcag agcgcagctc agatctcctt cttcagggtc tcgcccatga
    11401 tgtagccgta ggtcagagcg gcgtcgaagc ccatgccgta ctgcttggcg tccttctcct
    11461 cgatggagcc gcagacgtcg ccggcagcgt acaggccggg gatggccttc ttgtcctcgg
    11521 tcaggacgtg gcaatcggtg tcgatggcca gacctgcggt ggtcaggtag aaggtggggt
    11581 caacgcggat ggcccacaga ccgtcgcggg tctcgatgta ggggcagttg cggcggccga
    11641 actcatcggg ctcgccagcc agagcggcgg cgttgttggc ctcgatggcg tctgccagat
    11701 tgggcaggtt cagctcctca gaggccttct ccacgctgtc gtagtgcaca gcctcgccct
    11761 tctcgaacat agcaacgtaa ccgttgaagc cgtaggactc gctgtcgcgc agcttgacgg
    11821 cagaggactc gtcgaacaca tagtagaagg tgtcgccgtt gtctttattc agctttgcct
    11881 tggccatggt gtagtggtta tcggagacga tgttgccgat gttgtcgccc ttgatgttga
    11941 ccatgatgcc gggggcagac tggtggatga aggccagctc gaacttgctc ttgtagctgg
    12001 acaggaaggc gggcagagcg cggttttcgc actccacata gccgccggcg tcaataccca
    12061 tctggatgcc ctcgccggtc atgctggagg cgcagttgaa gaagaagtcg gcgtagtcgg
    12121 ggctgtactt cttcagcatt tcggggttct tggcaaagcc gccggaggca aggcagaccg
    12181 ccttgccgcg cagggtatag cttgcgccgt tttcgccctt ggcgtggaag cccacaacac
    12241 ggccgctctc gtccttgatc aggtcggtga cgctggtgga gtagatgatc ttgcccttct
    12301 cgtacttctc cacgcgctgt gccatgaaca tcatggcgta gcctgcgccg ccctcgtagc
    12361 agccgggtgc cagatacggg gtggaagcgc cgtactgggt agcgctttcg tagttgccca
    12421 tggtgttgaa gccgatgccg atgcctgcca tccagtccac cagatcaccg gcgacggtgt
    12481 actgcttggt catgtagggc atttcaccgt tgaagaactc ggtgcggtgg tacttctcca
    12541 tggtctgcca gaagttcatc atgccctcca gcgtgcccat ggcagagctg cggaagctgc
    12601 cgtccacatc gtagttgtac tgcagcttgg agcctgcggt ggcaacgccg ccgtaggtca
    12661 tggacatgga gccgccgggg atatcgcgct tctccaccag aatgacgctg tagccggcct
    12721 ccagcaggcg gcaggcgcag gtcagaccgg aggtgccggc acccatgatg acgacatcag
    12781 cctcttcctc gatgacctcg ttggaagcag cgatggtgac ctccttggag aagtcgtcca
    12841 cgttataacc ggccagctcg atggcctcct tcacagctgc cttgacagcc atggaggtga
    12901 tggaggagcc gcgcaggttg ggcacgttga cgctctggtg ctcgacgatg gcggcgggga
    12961 tgcgggagca ggcatagttg ccgatgccga tggtctcctc gtgagacagc acctcacagg
    13021 cagtgatctt gccatcaaag aaggtggtgg caacgtgcac ccagctttcg tgacccattg
    13081 ccttggtgac gtacttgccg tccaccgggg aggagggctt ggtcacagcg gaggaagcag
    13141 cagaggaagc tgcggaggaa gcgggagcac cggtggtgct ggaagcggag ttgccgcagg
    13201 cggtcagcag accggcagca gctgcgccca tggtgcccac agcggcaccg cgcataaagt
    13261 tgcgacgaga gatcttagcc ataaggttcg cctttctttt tcttttctct tcttttttgc
    13321 gtttttcctg ttccttcgtg cattttgaac attgatacga ttatagcaaa gttttgtccc
    13381 ggtgtgaaat acaaatttgt accataattt atcaaatctc tttataaatc gttttccctt
    13441 tacggcctgt gcggaatcct gtataataaa gatgaccagc tttttacaca aggaggtgcg
    13501 ccattctatg acgatttacc agttagagtg ctttattgcc gtagcagagg agctgaattt
    13561 cagcgccgcc gccgagcggc tgttcaccac ccagcccgcc atcacctacc agatcaatgc
    13621 gctggaaaag gagaccgggc tgcacctgtt cgagcgcacc acccgccgca ccaagctgac
    13681 cgctgccggg cagtcctttt atctggacat ggtgcagatg accagctttg ggcggcaggc
    13741 gctgaagaag gcgcaggata ttcaggacgc cgaccgctcc cacctgaccg tcgggctgcg
    13801 gcagctgttc gattacagca ccttttccag cattctggcc cagttccagc accagtttcc
    13861 caacgcctgc gtagacgttg tgccgcagga caaccgccgc ccactggaac agctgcgctc
    13921 cgggcagctg gatatcggct ttttctacgc caccgagcac tcccgcgacc gggacatctc
    13981 ctttacgccc ctgttcgccc tgggctacca tgtgctgatg aaccccaact ctccccttgc
    14041 cgaccggcgg gcgctgcatc tggcagacct gaaggggcag agcgtggtgt cctccggcgc
    14101 attcgacagc tttctgtccg cctgtcaggg gccgtcgctg gagcagctgg cgcaggtggg
    14161 ggtggattgc agcaagatca cccccagctt tgagggtgcg ctgatcatga tccagatggg
    14221 caccgccatg tctatcgtgc cctgcctttc cacggcggtg atcccgggca tcgtcaaggt
    14281 gccgctgctg gattttcccc cggtgacggt ggagatcgcc gccatgcgcc acgcaccccg
    14341 gctggaggta cagtccttta tcgagatcgc caagcagaaa tacgcccatc accccgaccc
    14401 gctgcggatg gaggcgctga tctgaggcac agctgctact gttcaaaagt ccccttgtgt
    14461 catagggctt cgccgcctgt tctgaacagc agctcctgcc ctgtaaaagc agaaaaccgg
    14521 acagcctgcg ggctgtccgg ttttttgtgc tatcgaaagg ttttactgat aatcgtggtt
    14581 gaggaacagg gccttgatga ccaccacctc gtcatattct tcctgctcca cctccacgtc
    14641 cgcgttcaag gatttcaggc gtgccttgac tgcatccagt gcctcgggca cggtgacggc
    14701 gcggccctcc tccacggcgt ccatcatctg cttgagcacg atggggtggg cgtaccagct
    14761 tttcaccggg aacgccccgt gggggtagtg cttgacatac tctgccatgg ctgcctcggc
    14821 cttttccgca cgcttcatga tggcgttgtt gttattgtgg gcggtgggca gcatattgta
    14881 gctggaaaac aggaagatgg cggcaaagcc gaacagcgca aagtacacgc cgtagctgcc
    14941 ggtgtggctg aacacggaat acagaccgta ggccgcagcc gcaacgccca gcacaaagat
    15001 ggccagcgcc acatagcggt acaccggttt gctttgcagc tgcgcacgct tgcggcgctg
    15061 ggcagcgctc agctcggcgg aaagctccgg ctttgcgtcc agatactcct ttgcccgacg
    15121 cagcacggta aggctgtgct gcgcgtcctc ggaaagctcc ggcagcttgc gggcggcctt
    15181 ttcagcggcc tttttctcca gcgcctgctc accggcagcg ctcagcagat gcagctgcgg
    15241 ctgctccttg gcaagcactt ccagcagggc gtccacgtcc cgctcgtcct tgaagttgca
    15301 ctgcttctgc ttgccgccgt cgtactccac cacaagatag gccatggagg caaacacgcc
    15361 cttgccggaa aagccgccgg agctcatagc cacccgcttg aacacccggg tgatgctgcc
    15421 gtagggcaga taatagcggc ggtcgatgta aaagctgttc aggtacagcg cctttttgcc
    15481 tacgccgcag gggccgatct tccggcaggc ttttttgtct gcctccagct cctgcgggtc
    15541 aagctttgcc atgcccagct gtgcgggttt gaaaatcatg ggtagttccc ttctttgctt
    15601 taaattctac gcccctattt tcccacggga cgggggcaat tgcaagccct gattttttca
    15661 aaaaacagcg cccgccgctg tacggtcagg cagcggcggg cgcaagttac ttacggaaat
    15721 atggagccgt cagttcctta tgccttggaa gtagagctct tcttggtagc atggaggaac
    15781 agagccagca ttgcgatggc aaagacgatg ccgatggggt aagcaacggc ggtgttgtaa
    15841 gccaccagct tgccgtccgc ataggtgttg atcatcttgc ccaggcactc gggagccagc
    15901 acgaagtagg tgcaggacac agcgctcatg aaggttgcag gcacggcggt gatccagaag
    15961 ttcttcttct ccttgaacag gtacatggaa gcagcccaca ggacgatcat agccagcgtc
    16021 tggttggtcc agctgaagta acgccagatg acggtgtagt tgatgaagcc cagtgcgttg
    16081 ccgatgccaa ggaaagcacc aacgcccagc acggggacac acagcttcag gcggtttgcg
    16141 tagctgtcct gatcgatctt gagccagtcg gccagagtca gacgag
//
