LOCUS       c00033_gnlPro..        13252 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|AEAHADKA_33.
ACCESSION   c00033_gnlPro..
VERSION     c00033_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-04 00:40:49
            Original ID  :: gnl|Prokka|AEAHADKA_33
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 13252
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     CDS             1..807
                     /locus_tag="ctg33_1"
                     /transl_table=11
                     /translation="KTVRKEWLEDLVIAETMKLIQDDAVIDAIVADVMELQDQENTTLP
                     LLEKQMREVENGIENMLNAIQAGVLTNSTKSRLEKLEAQQKELEVRIAEEKIARPRLSE
                     NQVRFWLTRFRKLDPNVKSHRETLINTFVNAVYLYDEKVLIAFNYKDGTKTISFNEIAA
                     KDASEGNGSDLGCFAPPRTPVSNGYRSFCFTCLEKGAARVDSNSCGAVAEDSAKTAQWA
                     VFSSAARAIHTRPPRTPVSEPGTGVSVLSALKRGCKGGFEQHRPAE"
     protocluster    1..13252
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[6003:10246]"
                     /cutoff="10000"
                     /detection_rule="(minimum(2, [AdoMet_dc, Spermine_synt_N,
                     Spermine_synth]) or (Orn_DAP_Arg_deC and Sacchrp_dh_C))"
                     /neighbourhood="10000"
                     /product="Putrescine2spermidine"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      6004..10246
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(minimum(2, [AdoMet_dc, Spermine_synt_N,
                     Spermine_synth]) or (Orn_DAP_Arg_deC and Sacchrp_dh_C))"
                     /neighbourhood="10000"
                     /product="Putrescine2spermidine"
                     /protocluster_number="1"
     cand_cluster    1..13252
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(minimum(2, [AdoMet_dc, Spermine_synt_N,
                     Spermine_synth]) or (Orn_DAP_Arg_deC and Sacchrp_dh_C))"
                     /kind="single"
                     /product="Putrescine2spermidine"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..13252
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="Putrescine2spermidine"
                     /region_number="1"
                     /rules="(minimum(2, [AdoMet_dc, Spermine_synt_N,
                     Spermine_synth]) or (Orn_DAP_Arg_deC and Sacchrp_dh_C))"
                     /tool="gutsmash"
     CDS             1054..1530
                     /locus_tag="ctg33_2"
                     /transl_table=11
                     /translation="MIYDTLNNLPNYLGVSDNLDTVIEYIMARDITTLPAGRTRIDGDK
                     AVVTVSTVTPQTSDKALFQRHDNHITLETDLDGSELFEVSLAELTPTKPTDEAADTTVG
                     TAGTSIAGMLCEGRFALYLAGEPYKSGLKAQGCGKLKKAVFSIELDPDEEETEE"
     CDS             1550..1789
                     /locus_tag="ctg33_3"
                     /transl_table=11
                     /translation="MGFFAVLAASLFAVFIFTVFGGYSLLLWCQQSLWMVVPPALVLAV
                     LVWTFLKMDDKITALQKRVDELEAAQKSTEKLEK"
     CDS             complement(1876..3192)
                     /locus_tag="ctg33_4"
                     /transl_table=11
                     /translation="MDLALFGRYFLDFALLYPSAFLCLASLWEKLRTPRRTACIAAGCI
                     TLLCIGCAALCAVFGLNSNSLLPAIVLVSFWLLRWRVTPEVTVSQTAFLFSISAVMMAV
                     CSLLSTLLNAHTEISNPQTVCLASTALLRLGLAAMLTVLFWFTAVQWSRWLLREYSGEA
                     FWQSAWPLLALYAVFLVYCMPLNPAVVLVGRLKIISVLAVSISLFGIFLLLYEMYRVAR
                     EFTRNARLDRENQLLAMESRRYMELQTYLDNTRRLRHDFRQHLHVIAGLTETGQLEELK
                     SYLHQYESELSEHRPSLCANAAVDALAGYYDHAAGQQSVPVEWKLALPRQLPMPEADLC
                     TILGNLLENALHASQKLPPEQRRVQVMAQMLSPAMLGLVVENRYDGMLKKQQGILHSTK
                     HEGTGIGLVSAETVVHKYNGNLHLETEEQIFRVNVLLNL"
     CDS             complement(3210..3953)
                     /locus_tag="ctg33_5"
                     /transl_table=11
                     /translation="MEKEGVWMALPIAIVEDQAADARRLEELLQQQLPAAECTWFTCGD
                     DFLRAAAEPGLYAVVFLDICMAGTNGIETARRLRQADPEVLIVFVTSSPEYVWDAFPVH
                     PFDYLLKPYQKEKFEHLAAELRRALRCQEPELEIRIARQSIQLPLRKVLYAIARNHYVL
                     ITTEDGEYRAMCSFAQIEEKLTALENFMSCNRGVIINMDKVLRFGEDCIEILDGTRLPV
                     RQKDKCTLLAHFTQYQFRHMRQELH"
     CDS             4525..5991
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) OKR_DC_1_C"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) OKR_DC_1_7_arginine"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg33_6"
                     /sec_met_domain="OKR_DC_1_C (E-value: 4.7e-12, bitscore:
                     36.3, seeds: 113, tool: rule-based-clusters)"
                     /sec_met_domain="OKR_DC_1_7_arginine (E-value: 1.8e-123,
                     bitscore: 401.9, seeds: 39, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNENKARSRLDQRRAPIYEALERFRQMRVVPFDVPGHKRGRGNPE
                     LTAFLGQQCVGVDVNSMKPLDNLCHPVSVIREAEELAADAFGAAHAFLMVGGTTSSVQS
                     MVLTACKRGDEIILPRNVHRSVLNALVLCGAVPVYVNPEVDKRLGISLGMKREQVAKAI
                     KEHPNAVAVLVNNPTYYGICSDLRAIVKMAHDAGMLCLADEAHGTHFYFGGGLPVSAMA
                     AGADMASVSMHKSGGSLTQSSLLLIGPNVHQGYVRQIINLTQTTSGSYLLMSSLDISRR
                     NLALRGRQVFHQVADIAEYAREEINAVGGYYAFGKELCNGDSVFDFDTTKLSVHTLDIG
                     LAGIEVYDILRDEYDIQIEFGDIGNILAYLSIGDRPQEVERLVSALAEIKRRYRTDGSG
                     LLSQEYIDPVVAASPQEAFYAPKKSLPLRETEGMVCSEFVMCYPPGIPILAPGERITKE
                     ILNYIEYAKAKGCSMTGPEDPEILHLNVLA"
     CDS             6004..6861
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Putrescine2spermidine: Spermine_synth"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Putrescine2spermidine: Spermine_synt_N"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg33_7"
                     /sec_met_domain="Spermine_synth (E-value: 3.2e-54,
                     bitscore: 173.1, seeds: 15, tool: rule-based-clusters)"
                     /sec_met_domain="Spermine_synt_N (E-value: 3.4e-23,
                     bitscore: 71.4, seeds: 13, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MEFWFSEFHTPDVKHSIRVNKQLYSKQSDYQRIDIFETPEFGRVL
                     TLDGNVMLTERDEFIYDEMIVHVPMAVHKEAKDILVIGAGDGGVVRELTRYDRVERIDL
                     VEMDPQVVEACRAYLPGNACRMDDRRVHIYFENALKYIRRCEEEYDLIIVDSSDPFGPS
                     EGLFTREFYGSCFNALKEDGIMVNQQGSPFYAEDASAMQRSHKRIASTFPISRVYQAHI
                     PTFAAGYWLFGFASKKYHPIDDLDAEAWKALNMRTRYYTTKLHIGAFYLPAFLEEMLRE
                     VEEH"
     CDS             6861..7736
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Arginase"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg33_8"
                     /sec_met_domain="Arginase (E-value: 3e-77, bitscore: 249.7,
                     seeds: 235, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MHPNVETFIGCDSSYRAASIVLYGAPYDSTTSYRPGARFGPAAVR
                     HESYGLETYSPYQNADLTDFDVFDSGDLELCFGSSELALADIEARAEEILKDGKFPLLL
                     GGEHLVTLGAVRAAVKKYPDLHIVHFDAHADLRDDYLGAKLSHACVLRRCHELVGDGHI
                     HQFCIRSGDRAEFEFAAQHTEMHKFDFTGLAELTAQLCESKVPVYLTIDLDCLDPSCFP
                     GTGTPEAGGVSFLQLLEAIRTVTKANIIGADLNELAPTLDTTGVSTATACKVLRETLIA
                     LDKGWPGFQV"
     CDS             7776..9035
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Putrescine2spermidine: Sacchrp_dh_C"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Sacchrp_dh_NADP"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg33_9"
                     /sec_met_domain="Sacchrp_dh_C (E-value: 3.9e-45, bitscore:
                     144.9, seeds: 375, tool: rule-based-clusters)"
                     /sec_met_domain="Sacchrp_dh_NADP (E-value: 1.7e-33,
                     bitscore: 105.6, seeds: 81, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSKVLIIGCGGVASVAIHKCCQVPEVFTEICIASRTKAKCDKLAA
                     ELAPTTATKITTAQVDADKVEEVIALIKAYQPDLVMNIALPYQDLTIMDACLACGVNYM
                     DTANYEPENTDDPEWRAIYEKRCKEAGFSAYFDYSWQWAYAKKFEEAGLTALLGSGFDP
                     GVTQAYCAYAKKHEFDTIDTIDILDCNGGDHGYAFATNFNPEINLREVSAPGSYWENGH
                     WVEIPAMSIKREYNFDQVGDKDMYLLHHEEIESLAKNIPEAKRIRFFMTFGQSYLDHMR
                     CLEDVGMLSTTPVNFNGQEIVPIQFLKALLPDPASLGPRTKGKTNIGCIFTGKKDGKDK
                     TYYIYNVCDHQECYKEVGSQAISYTTGVPAMCGALMLLTGKWTTKGVHTVEEFDPDPYL
                     DALDKYGLPRSESHNPALVD"
     CDS             9035..10246
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Putrescine2spermidine: Orn_DAP_Arg_deC"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg33_10"
                     /sec_met_domain="Orn_DAP_Arg_deC (E-value: 8.5e-15,
                     bitscore: 44.8, seeds: 500, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRVRDSRPPFAGLANLSEEQLHRLPTPCYLLDEAQLRRNGEILLG
                     VQQRTGCRILLAQKAFSNFNVYPVLAPYLAGTEASGLYESRLGREELPEKENHVFCAAY
                     RTDEFEELLQYADHIVFNSPSQLAKFGPAAKAAGKSIGLRINPECSTQEGHEIYDPCAP
                     GSRLGTTRAQWDAAVAAHPELPALLDGLHFHTLCEQDADALAVTLAAVEKKFADLLPRM
                     KWLNFGGGHHITRPGYALATLENCILSVRQKYGVQVYLEPGEAWALNAGYLVTTVLDTL
                     RNGDTSLAILDMSAACHTPDVIEMPYRPPLLDAGEAGEKAHTVRLGGPTCLAGDIIGDY
                     SFDAPLAEGDKLIFGDMAIYTTCKNNTFNGMPLPPIWLLGADGNCRELVHFGYQDFKMR
                     LGAQ"
     CDS             complement(10262..10420)
                     /locus_tag="ctg33_11"
                     /transl_table=11
                     /translation="MDCKRVTVIRIGPVISTRMKALHGNVWCFFVLSAVHLTSPFMKKA
                     FVAARRP"
     CDS             10911..11780
                     /locus_tag="ctg33_12"
                     /transl_table=11
                     /translation="MALDYFYGQVGELFSFYRIPKALFLESRFQNLSTDAKTLYGILLD
                     RMSLSAKNGWLDEQGRVFIIFTIEDVKRALCCADNKATKLLRELEEFGLIERKRRGLGR
                     PSLVYVKNFSAESSKSIFQNRDFHDSGGFKSASQDPAKSRCNKTEENSTEKSETYPFYS
                     EEDDGMSKHEQLEEYFSQSLELDILLRLCPDDEDTIYQIVDLLVDTCATNRKMLRIAGD
                     DKPAEVVRSRFMKLNADHIRFVLKCLAENSSPIRNMKQYLLASLYNAPTTMQLSYQNQT
                     NHDLANRR"
     CDS             11777..12613
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) CbiA"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg33_13"
                     /sec_met_domain="CbiA (E-value: 8.5e-27, bitscore: 83.7,
                     seeds: 79, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="VIKISKKATTIAIVNQKGGTGKTTTCENLGIGLAMEGKKVLLVDA
                     DPQGSLTISMGWQQPDELPTTLSTLMQKAINDQSIPPGEGVLHHAEGVDLIPANIELAG
                     MEVSLVNCMNREKMLKQVLDSAKREYDFILLDCTPSLGMLTVNALAAADTTLIPVQAQY
                     LSAKGLEQLLQTVQKVRRQINPKLKIEGILLTITDSRTNYGQQIDNLIRGAYGSKIKVF
                     DQTIPRSVRAAEISAVGKSIFQHDPKGKVAEAYQSLTKEVLANAEKQLKRVAERGR"
     CDS             12570..13250
                     /locus_tag="ctg33_14"
                     /transl_table=11
                     /translation="MPKSSLSVSLKGADDIFSTEESRQEQQREQVQRIPIGELFPFKDH
                     PFKVLDDESMQRTVESVEQYGVLSPLIARPRPEGGYEIISGHRRQHAAQLAGLDALPVI
                     VRQMDDDAAVLLMVDSNLQRENILPSERAFAYKMKLEALKNQGARSDLTSCQVGTKFRA
                     DELLAENSSESARNVQRFIRLTSLIPELLDMVDEKKIAFNPAVELSYLDEAQQRDFLEA
                     MNDTQ"
ORIGIN
        1 aagaccgtcc gtaaagagtg gctggaagat ttggtcatag ctgaaaccat gaagctgatt
       61 caggacgatg ccgtgattga tgccatcgtt gcagacgtga tggagttgca ggatcaggaa
      121 aacaccactc tccctttgct ggaaaagcag atgcgcgagg tagagaacgg cattgagaat
      181 atgctgaacg ccattcaagc tggtgtgctg accaattcca ccaagtcgcg tttggaaaag
      241 ctggaagccc agcagaaaga acttgaggtt cggatcgccg aagaaaaaat cgctcggcca
      301 cggttaagcg aaaatcaggt tcgtttctgg ctgacccggt tccgcaaact cgacccgaac
      361 gtgaaaagcc accgggagac gcttatcaac acgttcgtga acgccgttta tctttatgat
      421 gaaaaagttt tgattgcatt caactacaaa gacggcacaa aaaccatctc tttcaatgaa
      481 attgccgcca aagatgcctc agagggcaat ggttcggatt tgggttgctt cgctccacca
      541 agaactccgg tatccaatgg gtaccggagt ttctgtttta cctgccttga aaaaggggct
      601 gcaagggtgg attcgaacag ctgcggcgct gtcgcagaag acagcgcaaa aacagcccag
      661 tgggctgttt ttagcagcgc ggctcgcgca atccacacgc gcccaccaag gactccagta
      721 tccgaaccgg gtactggagt ttctgtttta tctgccttga aaaggggctg caagggtgga
      781 ttcgaacagc atcgacccgc cgaatagtcc ggcgggggaa agcccctgtg caacagcgac
      841 gaccgctgcc agcggcagaa acagggagga gctgttgggg ctgcggccag caggatgcgc
      901 gtgccgccca aggcacgatg cagccgctgg gagccgcgac ccgggttcct tttctgcgcg
      961 gctcgcgaca tctgcccgca cacatattgc atctgtccct gacctgtgat accatacagg
     1021 taactgaaac aacacagacg gaggactttt tctatgatct acgataccct gaacaacctg
     1081 cccaactatc tgggcgtaag cgacaatctg gacaccgtga tcgagtacat catggcgcgg
     1141 gatatcacca ccctgcctgc cgggcgcacc cgcatcgatg gggacaaggc ggtggtcacc
     1201 gtgagcaccg tcacgcccca gacctccgac aaggcactgt tccagcggca cgacaatcac
     1261 attacgctgg agactgactt ggacggcagt gagctgtttg aggtaagcct tgcggagctg
     1321 acgcccacca agccaaccga tgaagccgcc gacaccaccg taggcactgc cggtaccagc
     1381 attgccggaa tgctgtgcga gggacgcttt gccttgtatc tggcagggga accgtataaa
     1441 tccggcctga aggcgcaggg ctgcggaaag ctgaaaaaag ccgtgttcag cattgagctg
     1501 gacccggacg aggaagaaac ggaagaataa ctgaaaggag actttctgta tgggattttt
     1561 tgctgtactg gctgcaagtc tgtttgccgt atttattttt actgtattcg gcggctattc
     1621 gctgctgctc tggtgtcagc agtccctgtg gatggtcgtt cctcccgcgc tggtgctggc
     1681 cgttctggtc tggacatttt tgaaaatgga cgataagatc accgccctgc aaaagcgggt
     1741 ggacgagctg gaagccgcac aaaaaagcac ggagaagctt gaaaaataat acagcgccgc
     1801 ccttcgtaga gaaacctctc tgcaaaggac ggcgctgctt tttttgtgaa cgctttcacg
     1861 ttggcctgcc ggtggttaca gatttaacag aacattcacc cggaagatct gctcctcggt
     1921 ctccaaatgc agattgccgt tatatttgtg cactaccgtc tcggcagata ccagcccgat
     1981 gccggtgccc tcgtgcttgg tggagtgcaa gataccctgc tgctttttca gcatgccgtc
     2041 gtaacggttc tccaccacaa gccccagcat ggcgggactg agcatctgcg ccatcacctg
     2101 cacccggcgc tgctccggcg gcagcttctg gctggcgtgc agggcgtttt ccagcagatt
     2161 gcccagaatg gtgcacaggt cggcctccgg catgggaagc tgccggggca gtgctagctt
     2221 ccactccaca ggaacgctct gctgcccggc tgcatggtca taatatccgg ccagtgcatc
     2281 cacggcggcg ttggcgcaca ggctggggcg gtgctcactg agctcgcttt cgtactggtg
     2341 cagatagctt ttcagctcct ccagctgccc ggtctcggtc agtccggcaa tcacatgcag
     2401 atgctgccgg aagtcgtgcc gcagacggcg ggtgttgtcc agataggtct gtaactccat
     2461 gtaccggcgg gattccatgg ccagcagctg gttttcccgg tccagccggg cattgcgggt
     2521 aaactcccgg gcaacgcggt acatctcgta cagcagcaga aagatgccga acagcgagat
     2581 ggataccgcc agcaccgaga tgatcttcag ccgcccgacc agcaccacgg cggggttcag
     2641 cggcatacag tataccagaa aaacggcata gagggcgagc agcggccacg cagactgcca
     2701 gaaggcttca ccgctgtact cccgcagcag ccaccggctc cactgcacgg cggtgaacca
     2761 gaacagcacg gtgagcatcg cggcaaggcc cagccgcagc agcgccgtgg aggcaaggca
     2821 gacggtctgt gggttggaga tctcggtatg ggcgttgagc agcgtcgaca gcagggaaca
     2881 caccgccatc atcacggcag agatggaaaa cagaaacgcg gtctggctta cggtcacttc
     2941 cggcgttacc cgccagcgca gcagccagaa ggagaccagc acgatggcgg gcaggagaga
     3001 attgctgttc agcccgaaca cggcgcagag cgcggcgcag ccgatgcaca gcagggtgat
     3061 gcatccggca gcgatgcagg cggtgcgcct gggggtgcgc agcttttccc atagggatgc
     3121 cagacacaga aacgcgctgg gatacagcag cgcaaaatcc agaaaataac ggccgaacag
     3181 ggcaagatcc atggcggctg ctcctttcct cagtgcagct cctgccgcat gtggcggaac
     3241 tggtattgtg taaagtgggc aagcagggtg catttatcct tttgccgtac cggcaggcgg
     3301 gtgccgtcca agatctcgat gcagtcctcc ccgaaccgca gcaccttgtc catgttgatg
     3361 ataacgcccc ggttgcagct cataaagttt tccagagcag taagcttttc ttcgatctgc
     3421 gcaaagctgc acatggcacg gtactcacca tcctcggtgg tgataaggac gtagtggttc
     3481 cgggcaatgg cgtacagcac cttgcgcagc ggcagttgaa tgctctggcg ggcaatgcgg
     3541 atctccagct ccggctcctg acagcgcagc gcccgccgca gctcagcggc aagatgctcg
     3601 aatttttcct tctggtaggg tttgagcagg taatcgaagg ggtgcaccgg aaaggcgtcc
     3661 catacatatt ccggggagga ggtcacgaat acgatcagca cctccgggtc ggcctgtcgt
     3721 agccggcggg cggtctcgat gccgttggtg cccgccatgc agatatccag aaacaccacg
     3781 gcgtataagc cgggctctgc tgcggcgcgg agaaaatcat ctccgcaggt aaaccatgtg
     3841 cactcggctg caggcagctg ctgttgcagc agctcctcca gccgccgggc atctgctgcc
     3901 tggtcctcta cgatggcgat tggcagtgcc atccatacac cctctttctc cattcattgt
     3961 tcctttatta tagcatactg cggcgggaag ggtatctgct tttttgcaca aaacgcccca
     4021 ttttgcgcgc cgagcgccgc cctgcgcacc cgcagcgggc gactgccaaa aagttttggt
     4081 tgacagacgg ggcgaatcat gttattcttt tgttgatttt gagagacgcc gccttgcaga
     4141 gtcttttcaa agcaatttac tcgggaccgc ccaaacgggg ctaaggccat acggacagcc
     4201 gggtccactg ccgaccggcg gcgcaagctg ccattattga ttgagtttga agctcaaatt
     4261 ttataagttg gttcctttac aaccatgaaa ttgcgcagcc tatgcgcaga cttgtgaaac
     4321 ggtcaataag agtagtaaaa gtgtagttgc tatatagact ctcatcaccc cgtctttttg
     4381 gatcgcgaat aacgcgcagc accggcactt acggctgggt gctttatcag cgcggaaaaa
     4441 gctgctccaa gcgcaggtct gcatatttgt gcagtgtctg cgcttttttg ttgtgcaaaa
     4501 agaagaacag ggacggagga aatgatgaac gagaacaaag cgcgttcccg gctggatcag
     4561 cgccgtgcgc ccatttacga ggcgctggag cggttccggc agatgcgggt ggtgcctttt
     4621 gacgtgcccg gccacaagcg gggccgcggc aacccggagc tgaccgcttt tctgggtcag
     4681 cagtgcgtgg gcgtggacgt gaacagcatg aagccgctgg ataacctttg ccacccggta
     4741 tcagtcatcc gggaagccga ggagcttgcc gccgatgcct ttggcgcagc acacgccttt
     4801 ttaatggtgg gcggcaccac cagcagcgtg cagagcatgg tgcttaccgc ctgcaagcgg
     4861 ggcgatgaga tcattctgcc ccgcaacgtg caccgcagcg tgctgaacgc gctggtgctg
     4921 tgcggcgctg tgccggtgta tgtgaacccg gaggtggata agcgcctggg catttcgctg
     4981 ggcatgaagc gggagcaggt ggccaaggcc atcaaggagc accccaacgc tgtggctgtg
     5041 ctggtgaata accccaccta ctacggcatc tgctctgacc tgcgtgccat cgtaaaaatg
     5101 gcgcacgacg ccgggatgct ctgccttgcg gatgaagccc acggcaccca cttctacttt
     5161 ggcggcggcc tgccggtttc tgccatggcg gcgggcgcgg atatggcctc agtctccatg
     5221 cacaaaagcg gcggcagcct gacccagtcc agcctgctgc tcatcggccc caatgtgcat
     5281 cagggctatg tgcgtcagat catcaacctg acccagacta cctccggcag ttacctgctg
     5341 atgtccagtc tggatatctc ccgccgcaat ctggcgctgc ggggacggca ggtgttccat
     5401 caggtggcgg atattgccga gtatgcccgc gaggagatca acgccgtagg cggctactac
     5461 gcctttggca aggaactgtg caacggcgat tccgtctttg atttcgacac caccaaactc
     5521 agcgtccata cgctggatat tggtcttgcc ggcatcgagg tctacgacat cctgcgggac
     5581 gagtatgata tccagattga gttcggcgat atcggcaaca tccttgccta cctgtccatc
     5641 ggcgaccgtc cgcaggaggt ggagcgtctg gtcagtgcac tggcggagat caagcgccgc
     5701 taccgcaccg atggctcggg tctgctgagc caggaataca tcgaccccgt ggtggctgcc
     5761 agcccgcagg aggctttcta cgcccccaaa aagagcctgc ccctgcggga gaccgagggc
     5821 atggtgtgca gcgagttcgt gatgtgctat cccccgggca tccctatcct tgcacccggc
     5881 gagcgcatca ccaaggagat cttgaactac atcgagtacg ccaaggccaa gggctgcagc
     5941 atgaccggcc cggaggaccc cgaaatcttg cacctgaatg ttctggcata aggagggaaa
     6001 gagatggaat tttggttttc agagtttcac accccggatg tgaagcacag cattcgtgta
     6061 aacaagcagc tctactccaa gcagagcgat taccagcgca tcgatatctt tgagaccccg
     6121 gagttcggcc gggtgctcac gctggacggc aacgtgatgc tgaccgagcg cgacgagttc
     6181 atctacgacg aaatgatcgt ccatgtgccc atggcggtgc acaaggaggc caaggatatt
     6241 ctggtcatcg gcgccggaga cggcggcgtg gtgcgggagc tgacccgcta cgaccgcgtg
     6301 gagcgcatcg accttgtgga gatggacccg caggtggtgg aggcttgccg cgcctatctg
     6361 cccggcaatg cctgccgtat ggatgaccgc cgggtgcata tctattttga gaatgccctg
     6421 aagtatatcc gccgctgcga ggaagagtac gacctcatca tcgtggactc ctccgacccc
     6481 ttcggcccct ctgagggtct gttcacccgc gagttctacg gcagctgctt caacgccctg
     6541 aaagaggacg gcatcatggt caaccagcag ggcagtccct tctacgccga agatgccagc
     6601 gccatgcagc gcagccacaa gcgcattgca tccaccttcc ccatcagccg ggtgtatcag
     6661 gcacatatcc ctacctttgc ggcgggctat tggctgttcg gctttgcaag caaaaaatac
     6721 catcccattg atgatctgga cgcagaagcg tggaaggcgc tgaatatgcg cacccgctac
     6781 tacaccacca aactgcatat cggagcattc tacctgccgg cttttctgga ggagatgctg
     6841 cgggaagtgg aggaacactg atgcacccca acgttgagac ctttatcggc tgcgacagca
     6901 gctaccgcgc cgccagcatc gtgctgtacg gtgcgcctta cgattccacc accagctacc
     6961 gccccggtgc acggttcggc ccggcggccg tccggcacga gagctatggt ctggagactt
     7021 acagccccta ccagaacgcc gacctgaccg attttgacgt gttcgacagc ggcgatctgg
     7081 agctgtgctt tggctccagc gagctggcac tggccgatat cgaggcccgg gcagaggaaa
     7141 ttttgaagga cggcaagttc ccgctgctgc tgggtggcga gcatttggtc acgctgggtg
     7201 cggtgcgtgc tgcggtgaag aaataccccg acctgcacat cgtccatttc gacgcccacg
     7261 ccgacctgcg ggacgactat ctgggcgcga agctcagcca cgcttgtgtg ctgcgccgct
     7321 gccacgagct ggtaggggat ggccacatcc atcagttctg catccgcagc ggcgaccggg
     7381 cagagtttga gtttgctgcc cagcacaccg agatgcacaa gtttgatttt accggccttg
     7441 ccgagctgac cgcacagctg tgcgagagca aggtgccggt gtacctgacc attgatctgg
     7501 attgccttga tccctcctgc ttcccgggca ccggtacccc ggaggctggc ggcgtaagct
     7561 ttttgcaact gctggaggcc atccgcactg tgaccaaggc taacatcatc ggtgcagacc
     7621 tgaacgagct tgcccccacg ctggacacca ccggcgtttc caccgccacc gcctgcaagg
     7681 tgctgcgcga gaccctgatc gcgctggaca agggctggcc gggctttcag gtataaatac
     7741 gaacctacca ttttacagat aaaggagtaa ccgacatgag caaagttctg atcatcggct
     7801 gcggcggcgt ggcctctgtt gccatccata agtgctgcca ggtgcccgag gtgttcaccg
     7861 agatctgcat cgccagccgt accaaggcaa agtgcgataa actggctgct gagctggctc
     7921 ccaccaccgc caccaagatc accaccgcac aggtggacgc agacaaggtg gaagaggtca
     7981 tcgccctcat caaggcctac cagcctgacc tcgtgatgaa catcgccctg ccttatcagg
     8041 atctgaccat catggacgcc tgccttgcct gcggcgtcaa ctacatggac actgccaact
     8101 atgagcctga gaacaccgac gacccggagt ggcgtgccat ctatgagaag cgctgcaagg
     8161 aggccggctt ctctgcctac tttgattaca gctggcagtg ggcctacgcc aaaaaattcg
     8221 aggaagccgg tctgaccgct ctgctgggca gcggcttcga cccgggtgtg acgcaggctt
     8281 actgcgccta cgcaaaaaag cacgagtttg ataccattga caccatcgat attctggact
     8341 gtaacggcgg cgaccacggc tatgcctttg ccaccaactt taaccccgag atcaacctgc
     8401 gcgaggtgtc cgcccccggc agctactggg agaacggcca ctgggtagag atcccggcca
     8461 tgagcatcaa gcgggagtac aacttcgatc aggtgggcga caaggatatg tacctgctgc
     8521 accacgagga gatcgagtct ctggcaaaga acatcccgga ggcaaagcgc atccgcttct
     8581 tcatgacctt tggccagagc tatctggacc acatgcgctg tctggaggac gtgggcatgc
     8641 tgtccaccac tcctgtcaac ttcaacggac aggagatcgt gcccatccag ttcctcaagg
     8701 cgctgctgcc ggaccccgcc agccttggcc cccgcaccaa gggcaagacc aacatcggct
     8761 gcatctttac cggcaaaaag gacggcaagg ataagaccta ctacatctac aacgtctgcg
     8821 accatcagga gtgctacaag gaagtgggca gtcaggccat cagctacacc accggcgtgc
     8881 ccgccatgtg tggcgccctg atgctgctca ccggcaagtg gaccaccaag ggcgtgcaca
     8941 ctgtcgagga gtttgatccc gatccgtatc tggatgcact ggataagtac ggcctgcccc
     9001 gctccgagag ccacaacccg gctctggtgg actgatgcgg gtgcgcgaca gccgcccgcc
     9061 ctttgcgggg ctggcaaacc tgtccgagga gcagctgcac cgcctgccca ccccctgcta
     9121 tctgctggac gaagcccagc tgcgccgcaa cggcgagatc ctgctggggg tgcagcagcg
     9181 caccggctgc cgcattctgc tggcgcagaa ggctttttcc aacttcaatg tctacccggt
     9241 gctggcaccc tatctggcag gtaccgaggc cagcggcctg tacgagagcc gcttgggcag
     9301 ggaagaactg ccggagaagg agaaccatgt gttctgtgcc gcctaccgga cagatgagtt
     9361 tgaggaattg ctgcaatacg ccgaccacat cgtgttcaac tcgcccagcc agctggcaaa
     9421 gttcggcccg gcggcaaagg cagcgggcaa aagcatcggt ctgcgcatca acccggagtg
     9481 ctccacgcag gagggtcacg aaatttacga cccctgcgca cccggcagcc gtctgggcac
     9541 cacccgtgct cagtgggacg ccgccgtggc agcgcacccg gagctgcccg ccctgctgga
     9601 cggtctgcac tttcataccc tgtgtgagca ggacgccgat gcgctggcgg taacgctggc
     9661 cgcagtggag aaaaagtttg cagacctgct gcccagaatg aaatggctca acttcggcgg
     9721 gggacaccac atcacccgcc cgggctatgc ccttgctacg ctggaaaact gcatcctctc
     9781 ggtgcggcag aagtacggcg tacaggtgta tctggagccc ggcgaggctt gggcgctgaa
     9841 tgcaggctat ctggttacca ccgtgctgga caccctgcgc aacggagata ccagccttgc
     9901 cattctggat atgtccgcag cctgccacac cccggatgtc atcgagatgc cctaccgccc
     9961 gccgctgctg gacgccggcg aggcagggga gaaggcgcac actgtccgct tgggcggccc
    10021 cacctgcctt gcgggggata tcatcgggga ttacagcttt gacgcccccc ttgccgaggg
    10081 tgataagctc atcttcggcg atatggccat ctacaccacc tgcaagaaca acaccttcaa
    10141 cgggatgccc ctgccgccca tctggctgct gggcgcagac ggcaattgca gggaactggt
    10201 gcacttcggc tatcaggact tcaaaatgcg cttgggcgca cagtaaaata aaaagcgttt
    10261 gtcacggcct acgggctgcg acaaacgctt ttttcatgaa aggggacgta aggtgaacgg
    10321 cagataaaac aaaaaagcac cacacgtttc cgtgtagtgc tttcattctg gtggagatta
    10381 ccgggccgat tctgatcacg gtgaccctct tgcagtccat gcacggcact ctcctgggtg
    10441 agctaaaccc tcactcgttt ggcagcaaca aaaaagcacc acacgttttt gtgtagtgct
    10501 ttggttctgg tggagattac cgggatcgaa ccggtgacct cttgcatgcc atgcaagcgc
    10561 tctcccgaac cacgcactca cgcaccccca cgcaaaggtg cgaggatgga cgatatttgg
    10621 cgttagaacg ctttatttcg agaaagacac attctcaccc aaaagcaacg ctgttgctta
    10681 aacgagtttc attgacgatg tatagtttac atcctgtttc taggtgttgt caagatgttt
    10741 tatccccctt tcgacaccaa acaggttaaa ttcttcttat ttattaagct aaaaagcgca
    10801 attttgattt tcaaaaatcg gaattgcgct tttttatttc aaaaaatcta ttgcgaggag
    10861 attttctaca atgtcaacat cttaccaaca ctatttcaga gcacagccgt atggcccttg
    10921 attacttcta cggacaagtc ggagagcttt tctcattcta ccgcatcccg aaagcactct
    10981 ttttagagtc acgcttccaa aacctgtcaa ccgatgccaa aacactgtac ggtatcctgc
    11041 tcgaccgcat gagcctgtct gctaaaaatg gctggctgga cgagcagggc cgggtgttta
    11101 tcatcttcac aattgaggat gtcaagaggg cattgtgttg cgcagacaac aaagcgacca
    11161 agctgctgcg ggaacttgaa gaatttggtc tgattgaacg aaaacgtcga ggcttgggca
    11221 ggccaagttt ggtgtatgtg aaaaactttt cggcagaatc gtcaaaatca atattccaga
    11281 atcgtgattt tcacgattct ggaggcttca aaagcgcaag tcaagaccct gcaaaatcac
    11341 gatgtaataa gactgaggag aatagtactg aaaagagtga aacttatccc ttctattccg
    11401 aagaagatga tgggatgagc aaacacgaac aactggaaga atatttttcg cagtctttgg
    11461 agttagacat cctgctccgg ctctgcccgg acgatgagga cacaatctat caaatcgtgg
    11521 atctgctggt tgacacctgc gccaccaatc gcaagatgct gcgcattgcc ggggacgaca
    11581 agcccgccga agtggtgcgc agccggttta tgaagctgaa tgccgaccat atccgctttg
    11641 tgctgaagtg ccttgcagag aacagcagcc cgatccgaaa catgaaacaa tatctgctcg
    11701 cttctctgta caacgcaccc accacgatgc agctttccta ccagaaccaa accaaccacg
    11761 acttagcgaa tcggaggtga taaaaatttc aaagaaagca accacgattg ccatcgtcaa
    11821 ccagaaaggc ggcaccggca agaccaccac ctgtgaaaat ctgggcatcg gtctggcgat
    11881 ggagggcaag aaagttctgc tggtggacgc tgacccgcag ggcagcttga ccatcagcat
    11941 gggctggcag cagcccgatg aactgcccac caccctttcc accctgatgc agaaagccat
    12001 aaacgaccag agcattccac ccggcgaggg tgttctgcac catgcagaag gtgttgacct
    12061 aattccggca aacatcgaac tggcagggat ggaagtttcc cttgtgaact gcatgaaccg
    12121 ggaaaagatg ctcaagcagg tgctggacag tgccaagcgg gagtacgatt ttattctgct
    12181 ggactgcact ccttcccttg ggatgctgac cgtcaatgcc ttggcagcgg cagacaccac
    12241 cctgattccc gtgcaggcgc agtatctgtc tgcaaaaggt ttggaacagc ttttgcagac
    12301 tgtgcagaaa gtccgacggc agatcaaccc gaaactgaaa atcgagggca tcctgctgac
    12361 tataacagat agccgcacca actatgggca gcagatcgac aacctgattc ggggtgctta
    12421 cggcagcaag atcaaggtgt tcgaccagac cattccccgg tctgtccgtg ctgcggaaat
    12481 cagcgcagtg ggcaaaagca ttttccagca cgaccccaaa ggtaaggtgg cagaagccta
    12541 ccaatctctg acgaaggagg tgctggcgaa tgccgaaaag cagcttaagc gtgtcgctga
    12601 aaggggcaga tgacattttc tccacggaag aatcccgaca ggaacagcag cgggagcagg
    12661 tgcagcggat tcccattgga gaactgttcc ccttcaaaga ccatcccttt aaggtcttgg
    12721 atgacgagtc catgcagcgc acggtggaaa gcgtagagca gtacggcgtg ttgtctccgc
    12781 tgatcgcccg cccacgcccg gagggtggct atgaaatcat ctccgggcac cgccgtcagc
    12841 acgctgcaca gcttgccggg ctggatgctc tgcctgttat cgtccgtcag atggatgatg
    12901 atgccgcagt tttgctcatg gtggactcga atctccaacg tgaaaacatc ttgcccagtg
    12961 aaagggcttt cgcctacaaa atgaagctgg aagctctaaa aaatcaaggt gctaggtcag
    13021 atttaacttc gtgccaagtt ggcacgaagt tccgggcaga cgaattgctt gcggaaaact
    13081 ccagcgaaag tgcccgaaat gtccaaaggt ttatccgcct gaccagcctt atcccggaac
    13141 tgctggacat ggtagacgaa aagaaaattg cctttaatcc cgctgtggag ttgtcgtatc
    13201 tggacgaagc ccaacagcgg gattttttag aagcgatgaa cgacacccag aa
//
