LOCUS       gnlProkkaJNNEHKAM_23   15358 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|JNNEHKAM_23.
ACCESSION   gnlProkkaJNNEHKAM_23
VERSION     gnlProkkaJNNEHKAM_23
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2024-11-17 05:33:28
            Original ID  :: gnl|Prokka|JNNEHKAM_23
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 21295
            Orig. end    :: 36653
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..15358
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="True"
                     /core_location="[10000:10588]"
                     /cutoff="20000"
                     /detection_rule="(TIGR04223 or AgrB)"
                     /neighbourhood="10000"
                     /product="cyclic-lactone-autoinducer"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..10588
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(TIGR04223 or AgrB)"
                     /neighbourhood="10000"
                     /product="cyclic-lactone-autoinducer"
                     /protocluster_number="1"
     cand_cluster    1..15358
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(TIGR04223 or AgrB)"
                     /kind="single"
                     /product="cyclic-lactone-autoinducer"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..15358
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="cyclic-lactone-autoinducer"
                     /region_number="1"
                     /rules="(TIGR04223 or AgrB)"
                     /tool="antismash"
     CDS             230..1246
                     /locus_tag="ctg23_20"
                     /transl_table=11
                     /translation="MIFKPAQLGMAKLDPQELEADKKACRKIGPCGVGKKALYLNSFYI
                     DRRYYLPYGSITRVFKRVAMSSGGFSGKGVFASMAYLVVEYDGGKQKQCNFKDERDVDA
                     LLEVLAKEQPQLHLLSAAGEQALEKKAAEKAARKLPELSEDAQHSLTVLRRAKEYLDAK
                     PELSAELSAAQRRKRAQLQSKPVYRYVALAIFVLGVAAAAYGLYSVFSHTGSYGVYFAL
                     FGFAAIFLFSSYNMLPTAHNNNNAIMKRAEKAEAAMAEYVKHYPYGAFPVKSWYAHPIV
                     LKQMMDAVEEGRAVTVPEALDAVKARLKSLNADVEVEQEEYDEVVVIKALFLNHDYQ"
     CDS             complement(1566..2483)
                     /gene_functions="regulatory (smcogs) SMCOG1014:LysR family
                     transcriptional regulator (Score: 142; E-value: 3.8e-43)"
                     /gene_kind="regulatory"
                     /locus_tag="ctg23_21"
                     /transl_table=11
                     /translation="MTIYQLECFIAVAEELNFSAAAERLFTTQPAITYQINALEKETGL
                     HLFERTTRRTKLTAAGQSFYLDMVQMTSFGRQALKKAQDIQDADRSHLTVGLRQLFDYS
                     TFSSILAQFQHQFPNACVDVVPQDNRRPLEQLRSGQLDIGFFYATEHSRDRDISFTPLF
                     SLGYHALMNPNSPLADRRALHLADLKGQSVVSSGAFDSFLSACQGPSLEQLAQVGVDCS
                     KITPSFEGALIMIQMGTAMSIVPCLSTAVIPGIVKVPLLDFPPVTVEIAAMRHAPRLEV
                     QSFIEIAKQKYAHHPDPLRMEALI"
     CDS             2704..4617
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Pyr_redox_2"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) DAO"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg23_22"
                     /sec_met_domain="Pyr_redox_2 (E-value: 2.1e-09, bitscore:
                     28.2, seeds: 64, tool: rule-based-clusters)"
                     /sec_met_domain="DAO (E-value: 5.2e-13, bitscore: 40.5,
                     seeds: 521, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAKISRRNFMRGAAVGTMGAAAAGLLTACGNSASSTTGAPASSAA
                     SSAASSAVTKPSSPVDGKYVTKAMGHESWVHVATTFFDGKITACEVLSHEETIGIGNYA
                     CSRIPAAIVEHQSVNVPNLRGSSITSMAVKAAVKEAIELAGYNVDDFSKEVTIAASNEV
                     IEEEADVVIMGAGTSGLTCACRLLEAGYSVILVEKRDIPGGSMSMTYGGVATAGSKLQY
                     NYDVDGSFRSSAMGTLEGMMNFWQTMEKYHRTEFFNGEMPYMTKQYTVAGDLVDWMAGI
                     GIGFNTMGNYESATQYGASTPYLAPGCYEGGAGYAMMFMAQRVEKYEKGKIIYSTSVTD
                     LIKDESGRVVGFHAKGENGASYTLRGKAVCLASGGFAKNPEMLKKYSPDYADFFFNCAS
                     SMTGEGIQMGIDAGGYVECENRALPAFLSSYKSKFELAFIHQSAPGIMVNIKGDNIGNI
                     VSDNHYTMAKAKLNKDNGDTFYYVFDESSAVKLRDSESYGFNGYVAMFEKGEAVHYDSV
                     EKASEELNLPNLADAIEANNAAALAGEPDEFGRRNCPYIETRDGLWAIRVDPTFYLTTA
                     GLAIDTDCHVLTEDKKAIPGLYAAGDVCGSIEEKDAKQYGMGFDAALTYGYIMGETLKK
                     EI"
     CDS             complement(4703..6064)
                     /gene_functions="transport (smcogs) SMCOG1086:MATE efflux
                     family protein (Score: 286.7; E-value: 4.6e-87)"
                     /gene_kind="transport"
                     /locus_tag="ctg23_23"
                     /transl_table=11
                     /translation="MSSQTNTLTEGPLAKQIFLVSLPLALSNLLQVLFNMSDVAVVGRF
                     AGSTALGAVGSTSTLVTLFTGFLIGLSNGINVLVARFYGARHPKDVEKTVHSAAIISAV
                     AGVALLLIGLLGSPAMLRLLNTKEDLLPGAILYLRVYFLGMPALALYNFGNAVFSSIGD
                     TKKPLLYLSIAGALNIALNLFFVIVCDLSVVGVALASAISQCVSAFLILRALTRVQDCY
                     ALDVHKLQLDPVQAKSILALGVPAGLQNAIFAIANLFIQAGVNSFDSLMVKGNSAAANA
                     DGLIYDCMAAFYMACASFMSQNYGAGRPDRVKKSYFISLGYSFGVGLVLGAALFFCGPA
                     FLALFTTEAAVIDAGMKRVAVMAFAYCVSAFMDCTIAASRGLGKTVVPTVIVVLGSCVF
                     RVIWVYTIFAHFHTIPALYLLYPCSWILTALAEIAYFASCYKRAMAIFRKPAAA"
     CDS             complement(6076..7686)
                     /locus_tag="ctg23_24"
                     /transl_table=11
                     /translation="MTAVIYARYSSDNQREESIEGQIRECTAYAEKNDITIVKHYIDRA
                     ISAKTDNRPQFQQMIKDSDKKLFDIVLVWKLDRFARNRYDSARYKTQLKKNGVKLMSAT
                     EIISEGPEGIILESVLEGYAEYYSADLAEKVVRGQTENILKGRCNGGRGTFGYTLDSER
                     KFHIDPLASPFVLESFTKYRDGLTMKEIRDWLNENGIKNPVGGEFTYNSVEHMLKNRRY
                     IGELKFRDVVVPDAIPPIVPLELFDDVQEKIAKNKKAPARRKAEDDYLLTTKLHCGCCG
                     ALMFGESGTSRTGEVHRYYKCATAKKKKGCKKKTVRKQWLEDLVVNQTMQLVRDDAAME
                     SIIAKVMELQDRENTNLPLYEKQLRDAESGIQNMLNAIQAGILTSSTKERLEQLEETKR
                     ELEARIAEEKLAKPKIKEEFIRFWLMRFRKLDMSLKDQRQALVDTFINSIYLYDDKVLI
                     TFNYKEGTQTITFEEAAQAASKENGSDLDCFTAPRTAAQVLCSSPFYLFYRIHLAKAAQ
                     CLIIEAVPRCARVRLGCIG"
     CDS             complement(7885..8241)
                     /locus_tag="ctg23_25"
                     /transl_table=11
                     /translation="MEGKTDKISQKYLTEETITEYAKRWGKLLNENTSMRIWHANDVKS
                     VNIDYFDQRIISLVSRIPISVGELTADVLKAISAPVSDWYVMKRIEALLKKGVLQVVIP
                     NKIFYNTIVQLNEE"
     CDS             complement(8635..9201)
                     /locus_tag="ctg23_26"
                     /transl_table=11
                     /translation="MTNKIKRLISILLVTVLFLLTIQPAFATGNKRKIDDYSIEELLNL
                     SVQEQENLGFYVLAEVPMRIPVSNTDGSRVVSYIDGTWRVLYTKANGLGFYMSGTTVGI
                     GPDLIKNVSGTDYYTSYSDNIERSCPFSTTALVPEQSIYNTTYTYDFYDVGTYLDCSVG
                     CYFGVVGSSKPIYWSATTQVTIPKL"
     CDS             complement(9613..9750)
                     /locus_tag="ctg23_27"
                     /transl_table=11
                     /translation="MIPVDTLWILQNRTIKLWEAKNEKRQKQLFSYCSFCPLGLHFSMD
                     "
     CDS             complement(9689..9799)
                     /locus_tag="ctg23_28"
                     /transl_table=11
                     /translation="MSNSYYTHCYHDILYSYDSGGHLMDTTKSYHQAVGG"
     CDS             complement(9818..9988)
                     /locus_tag="ctg23_29"
                     /transl_table=11
                     /translation="MKKNKWVLLLIAFVAFLVLVYFIGACLNATAEALTIISLCIGILV
                     IYLVVKAIKSK"
     CDS             complement(10001..10588)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     cyclic-lactone-autoinducer: AgrB"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg23_30"
                     /sec_met_domain="AgrB (E-value: 9.3e-36, bitscore: 114.2,
                     seeds: 181, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MWERTLSQKSVRLFCEQKVIDEAKADAYVYGYELLISSVVSVLLV
                     VLIAVVCGDVRYALSFLIGFIPQRIYIGGYHATSHTRCYLAFSGLALICILLSKAIAAN
                     HLFRILTTVALLGISIFLSPIEAKNKPLSEKKRSSYKMVASVLSSIDFLLAIFNVLPYT
                     RHVVCYYLSKWVLIVFSTIPLVQQKFNANFCR"
     CDS             10768..11466
                     /locus_tag="ctg23_31"
                     /transl_table=11
                     /translation="MLKYHVAVCDDEKSDLDGIVQSVQQYDVQGCFDIETYMDGNELLS
                     ELQMQKKSFDLLLLDIEMPSNGFQLAQSLIQMEKHPLVVFVTKRHEYAVQGYGIAFRYL
                     VKPLDQTLFAAAMDAVLQELNSKHFTIEYDGVTMSLETSDIYFLESHGHKVLIHCKEQD
                     LTLRMSIPEALEQLPKRCFVSPHKSYLVNMEHIVYATGTAVFLSSGHQLPISRRKRQEF
                     NQIFNAYLGR"
     CDS             11463..12731
                     /locus_tag="ctg23_32"
                     /transl_table=11
                     /translation="MMLYYFVEFAGSFANIALLLLFIGRLFPKKEPVSRWFYAYVALLI
                     AGQCALSLFPDWVTQRTIYLLVGGFFLALLFYEVRPWQAVFASGAFFTLIALVEVLAML
                     LIGLRIPDTDILMQAGAARLVYVVFSNLIQIPLVVLISHFFSRKGNALRILWLLPIIAI
                     QIASIAVCYVAQYHAADDYFPDYMVGLMAVLLLINILIVFYVEALRENELEKFKVKFNE
                     QQYNLQMEYYQQLKERQEEVRSLQHDVKKYILAMQAVAEHGDTEELHKIAQAATNVFER
                     STNISAVGNPVVDALLNYYLRIAERNNIKVKLDVTIPEVLTISSLSLSIIIGNTFDNAI
                     EACCDLPAEQRIIHLQLRKQYRSLFYRLENPYSDTVRSIRIGEYHGYGLKNINRIVQEN
                     HGDFYTKKKDGVFTVQVRLNCEN"
     CDS             12813..13190
                     /locus_tag="ctg23_33"
                     /transl_table=11
                     /translation="MTRIRTYVIIPNKSTEISVKKRFCAVLFPAKIYRPATHPIILPSV
                     SPDKILRLYCVGGIFLFRGRLHLENFMSRPNVIPALQSTPLQNRGRNFVRGKRRFTYMS
                     SGTLYLFLRLNNSETTFGNTF"
     CDS             13187..13534
                     /locus_tag="ctg23_34"
                     /transl_table=11
                     /translation="MSAAVESKNRPVATNFQFLKILCSSGTTLLQRSCVSEVLLVGVAL
                     VGATLLHLLSQTALPLKSPTGAFIAALRCASQTRSHPKPCSWFTPDGANSNGVSCLHNF
                     TEKLSNRQEVQ"
     CDS             14045..14632
                     /locus_tag="ctg23_35"
                     /transl_table=11
                     /translation="MSKKCYRFFGGLLKAQAKWLNKMSEKGYRLVRTGRMLYEFEKCNP
                     DEVAYCVEFIGEKSKENATDYADFLEDMGYKVFFKNINLNYSVGKVRLRPWAETGGCIA
                     TNATTFNRELLIVEKSNDGKPFELHTSYDDKEKYYRTLRNPWLFLLLLFALFAIIKHSI
                     VLGIFSLVSAIPSILYQLQIINVRQKAKTWEK"
     CDS             14676..14963
                     /locus_tag="ctg23_36"
                     /transl_table=11
                     /translation="MLFIEIQKDCPAAFEEQHHAELTVYRAVAAYFKANDITKLPSPKK
                     LEAEYAQLASEKAKFYEQYKEAKEELLKLKTAKQIVVSFFREEKPAQQER"
     CDS             14976..15356
                     /locus_tag="ctg23_37"
                     /transl_table=11
                     /translation="MINLKIDPEFQSQIPPLTDDEFKQLEENILKEGKLLSPLIVWNNT
                     LVDGHNRYAILQKHPEICFSTMPLRFANREEALAWICKNQLGRRNLSPEQKRYLLGKQY
                     EAEKKAAKIFRGNQYTLAKKSGG"
ORIGIN
        1 tcgtctttgc catcgcaatg ctggctctgt tcctccatgc taccaagaag agctctactt
       61 ccaaggcata aggaactgac ggctccatat ttccgtaagt aacttgcgcc cgccgctgcc
      121 tgaccgtaca gcggcgggcg ctgttttttg aaaaaatcag ggcttgcaat tgcccccgtc
      181 ccgtgggaaa ataggggcgt agaatttaaa gcaaagaagg gaactaccca tgattttcaa
      241 acccgcacag ctgggcatgg caaagcttga cccgcaggag ctggaggcag ataaaaaagc
      301 ctgccggaag atcggcccct gcggcgtagg caaaaaggcg ctgtacctga acagctttta
      361 catcgaccgc cgctattatc tgccctacgg cagcatcacc cgggtgttca agcgggtggc
      421 tatgagctcc ggcggctttt ccggcaaggg cgtgtttgcc tccatggcct atcttgtggt
      481 ggagtacgac ggcggcaagc agaagcagtg caacttcaag gacgagcggg acgtggacgc
      541 cctgctggaa gtgcttgcca aggagcagcc gcagctgcat ctgctgagcg ccgccggtga
      601 gcaggcgctg gagaaaaagg ctgccgaaaa ggccgcccgc aagctgccgg agctttccga
      661 ggacgcgcag cacagcctta ccgtgctgcg ccgggcaaag gagtatctgg acgcaaagcc
      721 ggagctttcc gccgagctga gcgctgccca gcgccgcaag cgtgcgcagc tgcaaagcaa
      781 gccggtgtac cgctatgtgg cgctggccat ctttgtgctg ggtgttgcgg cggcggccta
      841 cggtctgtac tccgtgttca gccacaccgg cagctacggc gtgtactttg cgctgttcgg
      901 ctttgccgcc atcttcctgt tttccagcta caatatgctg cccaccgccc acaataacaa
      961 caacgccatc atgaagcgtg cggagaaggc cgaggcagcc atggcagagt atgtcaagca
     1021 ctacccctac ggcgctttcc cggtgaaaag ctggtacgcc caccccatcg tgctcaagca
     1081 gatgatggac gccgtggagg agggccgcgc cgtcaccgtg cccgaggcac tggatgcggt
     1141 caaggcacgc ctgaaatcct tgaacgcgga cgtggaggtg gagcaggagg aatacgacga
     1201 ggtggtggtc atcaaggccc tgttcctcaa ccacgattat cagtaaaagc agaaaagtaa
     1261 aaagccgggc agcctgcggg ctgtccggct tttgctttta cagggcagtg ctgctgttca
     1321 gaacaggcgg cgaagcccta tgatataagg ggacttttga agagtcggac attattacca
     1381 cttttttata ttgaatagta ttcaaaagta acgtagtttc gttgtgtttg cgactcttca
     1441 aaactttggc tacttttgaa gagtcggggc aaaaagcaca gtgttctgcg tgttttggcg
     1501 cagaaaaagt aactattcaa aactctatgg gtcatagggg acttttgaac agtcgcagct
     1561 gcgtctcaga tcagcgcctc catccgcagc gggtcggggt gatgggcgta tttctgcttg
     1621 gcgatctcga taaaggactg tacctccagc cggggtgcgt ggcgcatggc ggcgatctcc
     1681 accgtcaccg ggggaaaatc cagcagcggc accttgacga tgcccgggat caccgccgtg
     1741 gaaaggcagg gcacgataga catggcggtg cccatctgga tcatgatcag agcgccctca
     1801 aagctggggg tgatcttgct gcaatccacc cccacctgcg ccagctgctc cagcgaaggt
     1861 ccctgacagg cggacagaaa gctgtcgaat gcgccggagg acaccacgct ctgccccttc
     1921 aggtctgcca gatgcagcgc ccgccggtcg gcaaggggag agtttgggtt catcagcgca
     1981 tggtacccca gcgagaacag gggcgtaaag gagatgtccc ggtcgcggga gtgctcggtg
     2041 gcgtagaaaa agccgatatc cagctgcccg gagcgcagct gttccagcgg gcggcggttg
     2101 tcctgcggca caacgtccac gcaggcgttg ggaaactggt gctggaactg ggccagaatg
     2161 ctggaaaagg tgctgtaatc gaacagctgc cgcagcccga cggtcaggtg ggagcggtca
     2221 gcgtcctgaa tatcctgcgc cttcttcagc gcctgccgcc caaagctggt catctgcacc
     2281 atgtccagat aaaaggactg cccggcagcg gtcagcttgg tgcggcgggt ggtgcgctcg
     2341 aacaggtgca gcccggtctc cttttccagc gcattgatct ggtaggtgat ggcgggctgg
     2401 gtggtgaaca gccgctcggc ggcggcgctg aaattcagct cctctgctac ggcaataaag
     2461 cactccaact ggtaaatcgt catagaacga cgcccctcct tgtgtaaaaa gctggtcatc
     2521 tttattatac aggattccgc acaggccgta aagggaaaac gatttataaa gagatttgat
     2581 aaattctgac acaaatttgt atttcacacc ggggcaaaac tttgctataa tcgtatcaat
     2641 gttcaaaatg cacgaaggaa caggaaaaac gcaaaaaaga agagaaaaag aaaggcgaac
     2701 cttatggcta agatctctcg tcgcaacttt atgcgcggtg ccgctgtggg caccatgggc
     2761 gcagctgctg ccggtctgct gaccgcctgc ggcaactccg cttccagcac caccggtgct
     2821 cccgcttcct ccgcagcttc ctctgctgct tcctccgctg tgaccaagcc ctcctccccg
     2881 gtggacggca agtacgtcac caaggcgatg ggtcacgaaa gctgggtgca cgttgccacc
     2941 accttctttg acggcaagat cactgcctgt gaggtgctgt ctcacgagga gaccatcggc
     3001 atcggcaact atgcctgctc ccgcatcccc gccgccatcg tcgagcacca gagtgtcaac
     3061 gtgcccaacc tgcgcggctc ctccatcacc tccatggctg tcaaggcagc tgtgaaggag
     3121 gccatcgagc tggccggtta taacgtggac gacttctcca aggaggtcac catcgctgct
     3181 tccaacgagg tcatcgagga agaggctgat gtcgtcatca tgggtgccgg cacctccggc
     3241 ctgacctgcg cctgccgcct gctggaggcc ggctacagcg tcattctggt ggagaagcgc
     3301 gatatccccg gcggctccat gtccatgacc tacggcggcg ttgccaccgc aggctccaag
     3361 ctgcagtaca actacgatgt ggacggcagc ttccgcagct ctgccatggg cacgctggag
     3421 ggcatgatga acttctggca gaccatggag aagtaccacc gcaccgagtt cttcaacggc
     3481 gaaatgccct acatgaccaa gcagtacacc gtcgccggtg atctggtgga ctggatggca
     3541 ggcatcggca tcggcttcaa caccatgggc aactacgaaa gcgctaccca gtacggcgct
     3601 tccaccccgt atctggcacc cggctgctac gagggcggcg caggctacgc catgatgttc
     3661 atggcacagc gcgtggagaa gtacgagaag ggcaagatca tctactccac cagcgtcacc
     3721 gacctgatca aggacgaaag cggccgtgtt gtgggcttcc acgccaaggg cgagaacggc
     3781 gcaagctata ccctgcgcgg caaggcggtc tgccttgctt ccggcggttt tgccaagaac
     3841 cccgaaatgc tgaagaagta cagccccgac tacgccgact tcttcttcaa ttgcgcctcc
     3901 agcatgaccg gcgagggcat ccagatgggt atcgacgccg gcggctatgt ggagtgcgag
     3961 aaccgcgctc tgcccgcctt cctgtccagc tacaagagca agttcgagct ggccttcatc
     4021 caccagtctg cccccggcat catggtcaac atcaagggcg acaacatcgg caacatcgtc
     4081 tccgataacc actacaccat ggccaaggca aagctgaaca aggacaacgg cgataccttc
     4141 tactatgtgt tcgacgagtc ctctgccgtc aagctgcgcg acagcgagtc ctacggcttc
     4201 aacggttacg ttgccatgtt cgagaagggc gaggctgtgc actacgacag cgtggagaag
     4261 gcctctgagg agctgaatct gcccaatctg gcagacgcca tcgaggccaa caacgccgcc
     4321 gctctggctg gcgagcccga tgagttcggc cgccgcaact gcccctacat cgagacccgc
     4381 gacggtctgt gggccatccg cgttgacccc accttctacc tgaccaccgc aggtctggcc
     4441 atcgacaccg attgccacgt cctgaccgag gacaagaagg ccatccccgg cctgtacgct
     4501 gccggcgacg tctgcggctc catcgaggag aaggacgcca agcagtacgg catgggcttc
     4561 gacgccgctc tgacctacgg ctacatcatg ggcgagaccc tgaagaagga gatctgagct
     4621 gcgctctgac cccctgacaa aagcataaat aaagggctgc tgcacaaacc gtgcagcagc
     4681 cctttttata tcatatttcc tcttatgccg ccgcaggctt gcggaagatg gccatggcac
     4741 gcttgtagca gctggcaaaa taggcgatct ctgccagcgc ggtcagtatc cagctgcagg
     4801 gatacagcag gtacagcgcc gggatggtgt ggaagtgggc aaagatggtg tacacccaga
     4861 tcacccggaa cacgcaggag cccagtacca cgatgacggt gggcaccacc gtcttgccca
     4921 gcccgcggga ggcggcgatg gtgcagtcca taaaggcgga gacgcagtag gcaaaggcca
     4981 tcacagccac ccgcttcatg ccggcgtcaa taacggcggc ttcggtggtg aacagcgcaa
     5041 ggaaggccgg cccgcagaag aacagcgccg cgcccagcac aagccccacg ccgaaggagt
     5101 agcccagact gatgaagtag ctcttcttca cccggtcagg ccgtcccgcg ccgtagttct
     5161 ggctcataaa gctggcgcag gccatgtaga aggccgccat gcagtcgtag atcagcccat
     5221 ccgcgttggc ggcggcgctg ttgcccttga ccatcaaaga gtcaaaggag ttgacgcccg
     5281 cctgaatgaa caggttggca atggcaaaaa tagcattctg cagcccggca ggtacgccca
     5341 gcgcaaggat gctcttggcc tgcaccgggt ccagctgtaa tttatgtacg tccagcgcgt
     5401 agcagtcctg cacccgggtc agcgcccgca ggatcagaaa cgcggaaacg cactggctga
     5461 tggcactggc cagtgccacg cccaccacgc tcagatcgca tacgatgaca aagaacaggt
     5521 tcagcgcaat gttcagcgca ccggcaatag aaaggtagag cagcggcttt ttggtgtcgc
     5581 cgatggagct gaacactgcg ttgccgaagt tgtacagagc cagcgccggc atacccagaa
     5641 aatacacccg cagatacaaa atcgcgccgg gcagcagatc ctctttggtg ttcagcagcc
     5701 gcagcatggc gggggagccc agcaggccga tgagcagcaa cgccacaccg gcaacggcgc
     5761 tgatgatggc cgccgagtgg acggtctttt ccacgtcctt ggggtggcgc gcaccgtaaa
     5821 aacgcgccac cagcacgttg atgccgttgc tcagaccgat gagaaagccg gtgaacaggg
     5881 tcaccagcgt gctggtggag cccacagcgc ccagcgccgt agacccggca aagcgcccca
     5941 ccaccgccac gtccgacata ttgaacagca cctgcagcag gttggaaagc gccaacggca
     6001 gactgaccag aaagatctgc ttggccagag ggccttccgt cagcgtattc gtttgagaac
     6061 tcatactttt ttcctttatc ctatacatcc taaccgtacc cgcgcacacc ggggcacagc
     6121 ctctattata aggcactgtg ccgcttttgc aagatggatt cgataaaata aataaaaagg
     6181 actgctgcac aaaacctgtg cagcagtcct tggtgcagta aagcaatcca aatccgaacc
     6241 attttccttt gatgcggctt gggccgcttc ctcaaacgtg atggtctgtg taccttcttt
     6301 atagttaaag gttatcaaaa ccttatcatc gtacagataa atcgaattga tgaacgtatc
     6361 caccaacgct tgcctctggt ctttcaggct catgtccagt ttacggaagc gcatcagcca
     6421 gaaacggata aattcctctt tgatttttgg ctttgccagc ttttcttccg caatgcgggc
     6481 ttcaagctca cgcttggttt cttcgagctg ttccaaccgt tccttggtgg aactggtgag
     6541 gattccggct tgaattgcgt tgagcatatt ctggataccc gattctgcat cccggagctg
     6601 tttctcatag agaggaaggt tggtgttctc tcggtcttgc agctccatga ccttggcgat
     6661 aatggattcc atggcggcat cgtcccggac aagctgcatg gtctggttca ccaccagatc
     6721 ttccagccac tgtttgcgga cagttttctt cttgcagccc ttcttctttt tggccgtggc
     6781 acatttatag tagcggtgga cttctcccgt ccggcttgtg ccgctttcgc caaacatcag
     6841 cgcaccgcag caaccacagt gcagcttggt tgtcagcagg taatcgtcct ctgcctttct
     6901 tcgggcaggg gctttcttgt ttttggcaat cttttcctgc acatcatcga acagttccag
     6961 cggcacgatg ggcggaatcg catccggcac gaccacatcc cggaatttca gttctccgat
     7021 ataacgccgg tttttgagca tgtgctccac gctgttgtaa gtaaattcgc ctccgaccgg
     7081 gttcttgatg ccgttttcat tcagccagtc ccgaatctct ttcatcgtga ggccatcccg
     7141 atacttcgtg aacgattcca gcacgaaagg ggaggcaagc gggtcgatgt gaaatttccg
     7201 ctcggaatcc agcgtatatc caaacgttcc acgaccaccg ttgcagcggc ctttcaggat
     7261 gttctctgtc tgtccacgga caaccttttc ggcaaggtcg gcagagtagt attctgcata
     7321 gccctccaga accgattcca gaatgatacc ctctggcccc tcggagatga tctccgtagc
     7381 cgacatgagc ttgacaccgt tcttcttcag ctgggtctta taccgggcac tgtcgtagcg
     7441 attccgggca aagcggtcaa gtttccagac cagaacaata tcaaacagct tcttgtcgct
     7501 gtcctttatc atctgttgga attgagggcg attatccgtc ttggcagaga tggcgcggtc
     7561 aatgtagtgc ttgacgatag tgatgtcatt cttttcggca taggccgtgc attcacgaat
     7621 ctggccttcg atggattctt cgcgctggtt atcactggaa tagcgggcgt agatcacagc
     7681 ggtcatggca agcacctctc tttacacgtc attgaacggt ggagcgttct ttcaaagcac
     7741 tgtttcgtat aatgtatata ccatgttttg atggagaaat caagactttt tattatcttc
     7801 agtttttctt tttgaacaat tgacccaaca gccacccctc tcgttgaaat gaggtgactg
     7861 ttgggccgac ttgctcggat tcctttattc ttcgtttagc tggacgatgg tattataaaa
     7921 gattttgttt ggaataacga cttgaagaac accctttttc aaaagtgctt ctatgcgttt
     7981 catgacatac cagtcactta ccggagcaga aatcgctttt aatacgtctg cggtaagttc
     8041 accaaccgaa ataggaattc tcgatactaa actaataatt ctctggtcga aataatctat
     8101 gttaacgctt ttaacatcgt tcgcatgcca aatacgcatg gaggtgtttt cgtttaatag
     8161 ctttccccat cttttggcat actcagtaat agtttcttcc gtcaaatact tttgtgagat
     8221 cttatcggtt ttcccttcca taaattcttt cagaccttct ctggatgcaa gcaaaattct
     8281 atttgtacca tactttgctg catagtaaca aatataataa atgccgcacc aacaatcggc
     8341 agaactcctg acccaaacac gcagtggctt atgatttatc atatcacatt gaaccgcatt
     8401 cgctgtacca tgatatttcg accacagttg tctagcttca atttggctgt caggataata
     8461 ttctgaaagg caattcacga attgtttgca acgatattct gaatcgcaag catattgaag
     8521 ttctcccatt gataacataa acggaaacaa ctttacactt tcgacgatgc ctaaagctgc
     8581 taacatattg acatcactgg gttcaaaaac aatttcatcc atagctggtc aaaatcataa
     8641 tttcgggatg gtaacttgtg tagttgcact ccaatagatt ggtttgcttg agccaaccac
     8701 tccaaaataa cacccaacgc tgcaatcaag ataagttcca acatcataga agtcatatgt
     8761 ataggttgta ttatatatac tttgttctgg aactagtgct gtcgttgaaa atgggcagct
     8821 tcgttcgatg ttatcggaat agctcgtgta gtaatccgtt cctgaaacat tttttattaa
     8881 atccgggcca ataccgacgg tagttccact catataaaag cccaatccat tggcctttgt
     8941 ataaagaact ctccatgttc catcaatata cgatacaact cttgagccgt ctgtattaga
     9001 aacaggaatg cgcattggaa cctcggccaa aacataaaat ccgagattct cttgttcttg
     9061 cacagaaaga ttgagaagtt cttctatcga ataatcatcg atctttctct tatttccagt
     9121 tgcaaatgct ggctgaatgg tcaggagaaa taaaaccgtg accaatagaa tggaaatcag
     9181 ccgtttgatt ttgttagtca cagtatactg cctcctaatt tatttttttt cttcactcaa
     9241 tacactaaag ctccattgga atcaccttca ttaaattttc cccttcaggt gtatactcct
     9301 cggcaaataa atgtgaacca tacaaatgct gaaactacta gaatactgct ggaatagaaa
     9361 atattgtgac cttacactgc tttgggtgat tactttgctt tccttcattg aatagctaga
     9421 acaacagcta ctatcaagaa caaagttgaa agcccaagct gaacccatgc aattttttcg
     9481 ttttcggcat tgttacagcc tttggaggat actgccactt ggatataatg cactgctacg
     9541 attccatatg agaaaaacaa agaagcccaa gcataaggta ctgcgctttt atctgtcaat
     9601 cggacaagat tactagtcca tactgaaatg cagccccaaa gggcaaaagg agcaataaga
     9661 aaaaagttgc ttttgccttt tttcattctt agcctcccac agcttgatgg tacgattttg
     9721 tagtatccat aaggtgtcca ccggaatcat acgaatacaa aatatcatga tagcaatggg
     9781 tatagtagct attactcatg atcacatttt cctttcctta ttttgatttg attgctttta
     9841 cgactaaata aatgaccagt atgccgatgc agagcgaaat aattgtcaat gcctctgccg
     9901 ttgcattaag gcaagcacca ataaaataaa ccaataccaa aaatgcaaca aaagcgataa
     9961 gaagcagcac ccatttgttt tttttcatgt tatcacctcc ctatctacaa aagttggcat
    10021 taaatttttg ttgaaccaaa ggaattgttg agaatacaat caatacccat ttggagagat
    10081 agtagcaaac tacatgacgt gtatacggaa gcacattaaa aatggcaagc aggaaatcta
    10141 ttgacgaaag aacagatgcg accatcttgt aacttgaccg cttcttttca cttaaaggct
    10201 tattctttgc ttcgataggt gagagaaaga tagagatgcc caaaagagct actgttgtca
    10261 ggatacggaa aaggtgattt gctgcgattg ccttacttag caaaatgcag ataagtgcca
    10321 gtccggagaa tgccaaatag catctggtgt gcgatgttgc atggtatccg ccaatgtaga
    10381 ttcgctgtgg gataaaccca atcaaaaatg aaagtgcgta ccgcacatca ccacacacaa
    10441 cagcgattaa aacaacaagc agaacgctca caacagatga tatgagcaac tcgtacccat
    10501 agacatacgc atccgccttt gcttcatcta tcactttttg ctcgcagaaa agacggactg
    10561 atttttgaga cagcgtgcgt tcccacattg cagttgcgcc accttatctt ctgatttttg
    10621 cttcactgta tcataaattt cagcaaaatc aagaggtttg gcaaaactgg tcgttctggt
    10681 gacaaaagtg gtaggtcagg ctacttgtaa ggagcctttg cacagtctat aatagtagca
    10741 ggacattatt ttgtggaggt tgtcgaaatg ctgaagtacc acgttgcagt ctgcgatgat
    10801 gagaaatcag accttgatgg cattgttcaa agcgtccagc agtacgatgt gcaaggctgc
    10861 tttgacattg aaacttacat ggatggaaac gaacttctga gcgaattgca aatgcagaag
    10921 aaatcctttg atctgcttct tctcgatatc gagatgccat ccaacggttt tcagctggcg
    10981 cagtctttga ttcagatgga gaagcatcct ttggtggtat ttgtcacgaa gcggcatgag
    11041 tacgctgtgc agggatatgg cattgcattc cgctaccttg tcaaaccttt ggatcagacg
    11101 ctgttcgctg cggcaatgga tgccgtcctt caggaactga actccaaaca tttcacgatc
    11161 gaatacgatg gtgttaccat gtccttggaa acatcggaca tttactttct ggaaagccac
    11221 ggacataaag ttctgattca ctgcaaggag caagacctta cattgcgaat gagcattcct
    11281 gaagccttgg agcagcttcc caaacggtgc tttgtgtcac cacacaaaag ttatctcgtc
    11341 aacatggaac acattgttta cgctacggga accgctgttt ttctttccag cggacatcag
    11401 ctgccgatca gcaggaggaa gcgtcaggag ttcaatcaga tcttcaacgc ttatttggga
    11461 agatgatgct ttattatttc gttgagtttg cagggagctt tgccaacatt gccctgttgc
    11521 tgctttttat cggtcggctg tttcccaaaa aggagcccgt ctcaaggtgg ttctatgcct
    11581 atgttgcact cttgattgct gggcagtgtg ctttgagttt attcccggat tgggtgacgc
    11641 agcgcacgat ctatctttta gttggcggat ttttccttgc attgctgttc tatgaggttc
    11701 gaccgtggca ggcggttttt gcaagcggag ctttcttcac actgattgct ttggtggaag
    11761 tgcttgcaat gcttctgatt gggctgcgta tcccggatac cgacattcta atgcaggctg
    11821 gggcagcacg gttggtctat gttgtttttt caaacctgat tcaaattcca ctcgtagttc
    11881 tgatttcaca ttttttcagc cgaaagggaa atgctctgcg catcctatgg ctgttgccga
    11941 tcattgcgat tcaaatcgca agtatcgcgg tctgttatgt ggcacagtat catgctgcgg
    12001 atgattattt ccctgattat atggtcggcc ttatggctgt acttctcctt ataaacatcc
    12061 tgatcgtgtt ctatgtggaa gctctccggg aaaatgagct agaaaaattc aaagtcaagt
    12121 tcaatgagca gcagtacaac cttcaaatgg aatactacca gcagctcaaa gaacgtcagg
    12181 aagaagtccg ttctctacag catgatgtga agaaatacat tctggcgatg caggcagttg
    12241 cagaacacgg tgataccgaa gaacttcaca agatcgcaca ggccgccacg aatgttttcg
    12301 agcgttccac aaatatttct gctgtcggaa atcctgttgt tgatgctctt ttgaattatt
    12361 acttacgaat tgcggaaagg aataacatca aagtcaaact ggatgtgacg attcctgaag
    12421 ttctgacgat ctcatcgttg tctttgagca tcatcatcgg aaacacattt gacaatgcca
    12481 ttgaagcctg ctgcgacttg ccagcagaac agcgaatcat tcatctacag ctgcgcaagc
    12541 agtatcgcag tctcttttac cggcttgaga atccatacag cgataccgtt cgcagcatcc
    12601 gcatcggaga gtatcacggt tacggactaa agaacataaa tcgtatcgtt caagagaacc
    12661 atggcgactt ctacacaaag aagaaggacg gtgtgtttac cgtccaagtc cgcctgaact
    12721 gcgaaaatta aaacattctt ctaaaacgca gccttgcttt cgcttgtact ttgtgtgttt
    12781 cgttcatctg atgtattcat tatcctgaag tgttgacacg cattcgtact tatgttatca
    12841 ttcccaacaa atccacagag atttctgtaa agaaacgatt ctgtgcggtt ttatttcctg
    12901 cgaagattta ccgccccgca acacacccga tcattttgcc gtctgtttca cccgacaaaa
    12961 tccttcgcct gtactgcgtg ggcggtattt ttcttttccg gggaagattg caccttgaaa
    13021 atttcatgag ccgaccgaac gtgataccgg ctctccagtc aacgccgctg caaaacaggg
    13081 gcaggaactt cgttcggggc aaacggcgat tcacatatat gagcagtgga actctctact
    13141 tatttttgcg tcttaacaat tcggaaacaa ctttcggaaa tacgttttga gcgcagcagt
    13201 ggagagcaag aaccgtcccg tggccacaaa ttttcaattc ttgaaaattc tgtgttcctc
    13261 cgggactaca cttctgcaac gctcgtgcgt ttccgaagtg cttcttgttg gggtagcgct
    13321 tgtcggggcc acgctcctcc atctactgtc gcagaccgcg ctgccgctta aaagccccac
    13381 tggggctttc attgctgcgc tgcgctgcgc ttcgcaaacg cggtcccacc ccaaaccctg
    13441 ctcatggttc acacctgacg gtgcgaacag caacggcgtg tcgtgcttac ataacttcac
    13501 cgagaagtta tcgaacagac aggaggtaca atgaccaaaa cgaatgttca atcgacccct
    13561 agcaattccc agcaccacga cacgccgaac aacaaaacaa gaatagagta gaccgttctt
    13621 ttttcacaca tccctcaaat aatttttctg aatccgcttg acgaatacta cgtttagtga
    13681 tatgtttatt acagtaaccg taataaggag gtcaaaccat gcgagataat acaaaaggtg
    13741 gtgcgcttac agaagtcacc ttttatattt tactctctct ttatacgcca aaacacggat
    13801 acgccgtcat gcaatttatt gaagaaaaaa caggcgggcg gctttcccta ggcgcaggca
    13861 ctttatatgg agcattaaac tctttgcagg acaagaagtg gattgaacct tatggagata
    13921 gtgagggaag aaaaaaagaa taccacatta cagcacaggg aaaagaaatt gcagaaaaag
    13981 agcttgcaag actaaacgaa cttgtacgca tcgcaagtga aattattgga gaggtacaga
    14041 cagtatgagt aaaaaatgct atcgcttctt tggtggattg ctaaaagcac aggcaaaatg
    14101 gttaaacaaa atgtccgaaa aaggctatcg acttgtccgg acaggaagaa tgctctatga
    14161 attcgaaaaa tgtaatcccg atgaagtggc ctattgtgta gagtttattg gagaaaaatc
    14221 aaaagagaac gcaacggact acgctgattt tttggaggat atgggctaca aggtattttt
    14281 caagaatatc aatctaaact attctgtcgg aaaagttcga ttgcgtccat gggcggaaac
    14341 gggcggttgt attgcaacaa acgcaacaac ttttaacagg gaactattga ttgtagaaaa
    14401 atcaaacgac ggaaaacctt ttgaactcca tacctcttat gacgataaag aaaaatacta
    14461 ccgcactttg cgtaacccat ggctattcct gctgctccta tttgcactgt ttgcgattat
    14521 caagcattct attgtcttgg gtattttttc attggtttct gcaattccca gcattctata
    14581 ccagctccaa attataaatg tccgacaaaa agccaaaacg tgggaaaaat aaataacaat
    14641 caagagggtg acaacaaaag ctgtcaccct cttgattgtt atttatagaa atacaaaaag
    14701 attgccccgc agcctttgag gagcagcacc atgcagagct gacagtatac cgggcagtag
    14761 cagcctattt caaggcaaac gacatcacca agctgcccag cccgaaaaag ctggaagccg
    14821 agtatgcgca gttggcatcc gaaaaggcaa agttctacga gcagtacaag gaagccaagg
    14881 aagaactgct caaactgaaa accgcaaagc agattgttgt gtcctttttc cgggaggaaa
    14941 aaccggcgca gcaggagaga taaaggagtg tgcgtatgat caacttgaaa atcgacccgg
    15001 agttccagtc ccagattcct cctctgaccg atgatgaatt taagcagctt gaagaaaata
    15061 tcctgaaaga gggcaagctg ctctctcctt tgatcgtttg gaacaataca cttgttgacg
    15121 gtcacaaccg ttatgcgatt cttcagaaac atcccgaaat ctgcttttct accatgccgc
    15181 tccgctttgc aaatcgtgag gaagcactcg cctggatttg caagaatcag ctggggcggc
    15241 gcaatctttc ccccgaacag aaacgttacc tgctggggaa gcagtatgaa gctgaaaaga
    15301 aagctgcaaa aatctttcgg ggtaatcagt acactttagc aaagaaaagt ggtggtga
//
