LOCUS       c00014_gnlPro..        11606 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|MEMKEIBP_14.
ACCESSION   c00014_gnlPro..
VERSION     c00014_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2025-04-30 09:15:21
            Original ID  :: gnl|Prokka|MEMKEIBP_14
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 11606
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..11606
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[1176:11443]"
                     /cutoff="10000"
                     /detection_rule="(TPP_enzyme_C and not (PFL-like or
                     PFL_6_pcresol or PFL_9_tma or Gly_radical or Gly_430_pcre
                     or Gly_8-9_TMA or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and
                     minimum(2, [ALS_ss_C, AlaDh_PNT_C, Arginase, BKACE,
                     BcrAD_BadFG, Beta_elim_lyase, CPSase_L_D2, Cys_Met_Meta_PP,
                     ELFV_dehydrog, GRDB, Glu_syn_central, Glu_synthase,
                     Gly_reductase, HAAA1, HG2B1, HG2B2, HGD-D, HleuD1, HleuD2,
                     HleuS1, HleuS2, Homoserine_dh, ILVD_EDD, IlvC,
                     Lactoyl-CoA1, Lactoyl-CoA2, Lyase_aromatic, MAAL_C,
                     OKR_DC_1_5_lysine, OKR_DC_1_5_ornithine,
                     OKR_DC_1_7_arginine, OKR_DC_1_C, OTCace, PALP,
                     Proline_reductase, Sacchrp_dh_C, TPL, Thr_dehydrat_C, TnaA,
                     Urocanase]) and not (POR or POR_N or PFOR_II))"
                     /neighbourhood="10000"
                     /product="TPP_AA_metabolism"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      1177..11443
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(TPP_enzyme_C and not (PFL-like or
                     PFL_6_pcresol or PFL_9_tma or Gly_radical or Gly_430_pcre
                     or Gly_8-9_TMA or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and
                     minimum(2, [ALS_ss_C, AlaDh_PNT_C, Arginase, BKACE,
                     BcrAD_BadFG, Beta_elim_lyase, CPSase_L_D2, Cys_Met_Meta_PP,
                     ELFV_dehydrog, GRDB, Glu_syn_central, Glu_synthase,
                     Gly_reductase, HAAA1, HG2B1, HG2B2, HGD-D, HleuD1, HleuD2,
                     HleuS1, HleuS2, Homoserine_dh, ILVD_EDD, IlvC,
                     Lactoyl-CoA1, Lactoyl-CoA2, Lyase_aromatic, MAAL_C,
                     OKR_DC_1_5_lysine, OKR_DC_1_5_ornithine,
                     OKR_DC_1_7_arginine, OKR_DC_1_C, OTCace, PALP,
                     Proline_reductase, Sacchrp_dh_C, TPL, Thr_dehydrat_C, TnaA,
                     Urocanase]) and not (POR or POR_N or PFOR_II))"
                     /neighbourhood="10000"
                     /product="TPP_AA_metabolism"
                     /protocluster_number="1"
     cand_cluster    1..11606
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(TPP_enzyme_C and not (PFL-like or
                     PFL_6_pcresol or PFL_9_tma or Gly_radical or Gly_430_pcre
                     or Gly_8-9_TMA or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and
                     minimum(2, [ALS_ss_C, AlaDh_PNT_C, Arginase, BKACE,
                     BcrAD_BadFG, Beta_elim_lyase, CPSase_L_D2, Cys_Met_Meta_PP,
                     ELFV_dehydrog, GRDB, Glu_syn_central, Glu_synthase,
                     Gly_reductase, HAAA1, HG2B1, HG2B2, HGD-D, HleuD1, HleuD2,
                     HleuS1, HleuS2, Homoserine_dh, ILVD_EDD, IlvC,
                     Lactoyl-CoA1, Lactoyl-CoA2, Lyase_aromatic, MAAL_C,
                     OKR_DC_1_5_lysine, OKR_DC_1_5_ornithine,
                     OKR_DC_1_7_arginine, OKR_DC_1_C, OTCace, PALP,
                     Proline_reductase, Sacchrp_dh_C, TPL, Thr_dehydrat_C, TnaA,
                     Urocanase]) and not (POR or POR_N or PFOR_II))"
                     /kind="single"
                     /product="TPP_AA_metabolism"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..11606
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="TPP_AA_metabolism"
                     /region_number="1"
                     /rules="(TPP_enzyme_C and not (PFL-like or PFL_6_pcresol or
                     PFL_9_tma or Gly_radical or Gly_430_pcre or Gly_8-9_TMA or
                     PFL_acetate1 or PFL_acetate2 or Gly_radical_scatole or
                     PFL_proline or PFL_toluene) and minimum(2, [ALS_ss_C,
                     AlaDh_PNT_C, Arginase, BKACE, BcrAD_BadFG, Beta_elim_lyase,
                     CPSase_L_D2, Cys_Met_Meta_PP, ELFV_dehydrog, GRDB,
                     Glu_syn_central, Glu_synthase, Gly_reductase, HAAA1, HG2B1,
                     HG2B2, HGD-D, HleuD1, HleuD2, HleuS1, HleuS2,
                     Homoserine_dh, ILVD_EDD, IlvC, Lactoyl-CoA1, Lactoyl-CoA2,
                     Lyase_aromatic, MAAL_C, OKR_DC_1_5_lysine,
                     OKR_DC_1_5_ornithine, OKR_DC_1_7_arginine, OKR_DC_1_C,
                     OTCace, PALP, Proline_reductase, Sacchrp_dh_C, TPL,
                     Thr_dehydrat_C, TnaA, Urocanase]) and not (POR or POR_N or
                     PFOR_II))"
                     /tool="gutsmash"
     CDS             complement(2..295)
                     /locus_tag="ctg14_1"
                     /transl_table=11
                     /translation="MDMSGTYMPLAKKLFPNAKIVLDRFHIIQHLGRAFLKTRIAIMNQ
                     FDKKSLPYRALKNHWRLFQKDSRKLSLNSFYSKTFRQTLAPHEVVEKTLDFSE"
     CDS             complement(404..922)
                     /locus_tag="ctg14_2"
                     /transl_table=11
                     /translation="MRLIKNTTELIGIKDQNIKISLVFETDTHIEIQAKLDYPAPSCPH
                     CHGKMIKYDFQKPSKIPLLEQAGTPTLLRLKKRRFQCKNCRRVTVAETSIVEKNCQISN
                     LVRQKVTQLLTEKMSLTDIARKLRVSTSTVYRKLDQFTFKEHYDKLPTVMSWDEFGFKK
                     GEFAFVAQN"
     CDS             1177..2661
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: PALP"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg14_3"
                     /sec_met_domain="PALP (E-value: 2e-17, bitscore: 52.8,
                     seeds: 146, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTLVYQSTRDENNKVTASQAILQGLATDGGLFTPLSTPEVTLNFD
                     QLKDASYQEVAKLVLSAFLDDFTEEELDYCITNAYDDKFDTAAIAPVVKLKNHYNLELF
                     HGSTIAFKDMALSILPYLLTTSAKKQGVDNKIVILTATSGDTGKAAMAGFADVPGTEII
                     VFYPKDGVSKIQELQMTTQTGANTHVIAIDGNFDDAQTDVKRMFNDVDLREKLLAHHTQ
                     FSSANSMNVGRLVPQVVYYVYAYAQLVKAGHIQNGDKVNFTVPTGNFGNILAAYYAHQI
                     GVPVGKLICASNENNVLTDFFATGTYDKKRDFKVTTSPSMDILVSSNLERLIFHLLGND
                     ATKTKELMDALVTKGEYTLADADKDILDLFAAGFATEDETAAEIKRVYDEDKYIEDPHT
                     AVASAVYEAYVQKTDDHTPTVIASTASPYKFPRVAVSAVTGKDSGDDFKAVEDLHQLSG
                     VAIPAAVDGLEHAEVRHKTVVAAADMQKAVESYLGV"
     CDS             2722..4008
                     /locus_tag="ctg14_4"
                     /transl_table=11
                     /translation="MTETKKILNIALPAMAENLLQMLMGVVDSYLVAQVGIVAISGVSV
                     ANNIITIYQAIFIALGASSASVIARSLGKGDVKATNRDTWDAIIITLALSLILGLLSIF
                     GGGAILNLLGTEQSVTQAGSLYLALVGGGVVFLALMTTFGNILRAKGRPRISMVVSLLT
                     NVLNAILSSLAIFVGHWGIVGVATATVFSRLVGTVILWQAMKLDVKQLEITKPFNRELL
                     GIALPAAGERLMMRAGDVVIVAIIVTFGTAVVGGNAIGENLTQFNYMPGMGVATATVIL
                     VANSLGRGDKTQMKRIIRESYWISTFLMVLVSGSILLFGQGLSGLFTDNKAAIAASQVV
                     ILYSFLGNPVTSGTLVYTAVWQGLGKAKMPFYATTIGMWIIRIFSGYFLGVSLGMGLAG
                     VWIATVVDNVWRAIFLYVMYRRYLVKRKF"
     CDS             4120..4485
                     /locus_tag="ctg14_5"
                     /transl_table=11
                     /translation="MTVKINTKDGQIELSDDVIATVVGGSATEIFGVVGMASKSAIRDN
                     FQALLGKENYAKGVVVKSTDAGITVDVYTVMSYGVKISEVSKNIQERVKFNLENQLGIK
                     AETVNVYVQNIKVVGEN"
     CDS             4485..6152
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Dak2"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg14_6"
                     /sec_met_domain="Dak2 (E-value: 2.4e-44, bitscore: 140.7,
                     seeds: 138, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="VSKITTSLLQEMVQAAATRLGKQAEYVNSLNVFPVPDGDTGTNMG
                     MTMDNGAKAVADQSASTVGEVGQILSKGLLMGARGNSGVITSQLFRGFGQSIKDKTELD
                     GQDLAHAFQAGVEVAYKAVMKPVEGTILTVSRGAASAAIKKAESTNDAVEVMRAALDGA
                     KAALAKTPEMLPVLKEVGVVDSGGQGLVFIYEGFLSALTGEYIASEDFQATPATMTEMI
                     NAEHHKSVAGHVATEDITFGYCTEIMIGLKQGPTYVKDFDYEEFQNYLSNLGDSLLVVN
                     DDEIVKVHVHTEDPGLVMQEGLKYGALVKVKVDNMRNQHDAQVQKEEAIQAAPSAPKDF
                     ALIAVVAGDGLADIFKSQGVDYVISGGQTMNPSTEDIVKAIEQVNAKNVIILPNNKNIF
                     MAAQSAAEVVDVNAAVVETRTVPQGFTSLLAFDPSQSIEANVEAMTASLSDVTSGSVTL
                     AVRDTTIDGLEIHENDILGMVDGKILVSTPDMDQALLDTFDKMIDEDSEIVMIYVGEEG
                     NQEQAQALAEKLEEAHEGIEVEIFQGDQPVYPYLFSVE"
     CDS             6322..8043
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: ILVD_EDD"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg14_7"
                     /sec_met_domain="ILVD_EDD (E-value: 2.8e-225, bitscore:
                     738.1, seeds: 918, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRSDMIKVGVDKAPARGLLYATGQVKSAKDMQKPFIAICNSYIDI
                     VPGHVHLRELADIAKEAIREAGGIPFEFNTIGVDDGIAMGHIGMRYSLPSRELIADSAE
                     TVINAHWFDGVFYIPNCDKITPGMILAAMRTNVPAVFCSGGPMKGGVDMTGHQATLSSL
                     FEAVGTYQAGDMSKEELDYLEKNACPTCGSCSGMFTANSMNCLMEVLGLALPGNGTILA
                     VSDERRELVRQAATKLMDNIKNNVRPRDIVTKEAIDDAFALDMAMGGSTNTVLHTLAIA
                     REAGIDYDLKDINEIAKKTPYLSKIAPSSVYTMHDVHEAGGVPAIINQLIKKGAIKGDR
                     ITVTGKTLKENVAGAEIKNEEIIHPIEHPISPVGGLSILYGNIAQDGAVIKVGGVDPSV
                     KTFRGKAICCDSQDQALELIDNGTVKKGHVVVIRYEGPQGGPGMPEMLAPTSKIVGRGL
                     GKDVALITDGRFSGATRGIAIGHVSPEAAEGGNIALIEDGDEIVIDLPNRTLDLLVDDV
                     TLEERRKHLKPFKSKISSGWLRRYTAFAKSANVGGTLMSDEEFEERKAERQAQEKN"
     CDS             8177..9877
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: TPP_enzyme_C"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg14_8"
                     /sec_met_domain="TPP_enzyme_C (E-value: 1.1e-48, bitscore:
                     154.3, seeds: 323, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="VKKIELEEARSGADLILDTLLELGISTIFGYPGGAVLPLYDAIYK
                     NDKINHILSRHEQGSLHEAEGYAKSTGKLGVALVTSGPGATNAITGIADAMSDSVPLLV
                     FTGQVATSGIGKDAFQEADIVGITMPITKYNYQIRDTADIPRIIREAVHIATTGRPGPV
                     VIDLPKDVVAKETAFINDPEINLPSYQPTLRPNEMQIKKILKQLGKAKKPVIVAGGGVS
                     YSESAKELVAFAERYQIPVVTSLLGQGTIATSHPLFLGMGGMHGSYAANIAMTDADFMI
                     AIGCRFDDRLTGNPKTFAKNAKVVHIDVDPAEIGKIIAVDLPVVGDAKQALEMLLAEPV
                     VQNNTEKWIEKVTKDKERVRSYDKKERMVQPQAVIERIGELTKGDAVVVTDVGQHQMWT
                     AQYYPYQNERQLVTSGGLGTMGFGVPAAIGAKIANPDKEVILFVGDGGFQMTNQELAIL
                     NIYKVPIKVVMLNNHSLGMVRQWQESFYEGRTSESVFDTLPDFQLMAQAYGIKSYKFDN
                     PETIDQDLEVIKEDVPMFIEVDISRKEHVLPIVPAGKSNHEMLGVKFNA"
     CDS             9870..10346
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: ALS_ss_C"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg14_9"
                     /sec_met_domain="ALS_ss_C (E-value: 3.5e-29, bitscore:
                     90.4, seeds: 685, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRRMLTAKLQNRSGVLNRFTGVLSRRQVNIESISVGASEDPNVSR
                     ITIIIDVNSQNEVEQIIKQLNRQIDVIRIRDITDQPHLEREVILVKVSAPTSKRAEILA
                     IIQPFRASVVDVAPSSITIQMTGDAEKSEALLRVIRPYGIKNIARTGATGFTRD"
     CDS             10421..11443
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: IlvC"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) IlvN"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg14_10"
                     /sec_met_domain="IlvN (E-value: 9.6e-81, bitscore: 258.6,
                     seeds: 43, tool: rule-based-clusters)"
                     /sec_met_domain="IlvC (E-value: 1.8e-63, bitscore: 202.6,
                     seeds: 295, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAVQMEYEKDVKVAALDGKKIAVIGYGSQGHAHAQNLRDSGHDVI
                     IGVRPGKSFDKAKEDGFDTYTVAEATKLADIIMVLAPDEIQKDIYKDEIEPNLSAGKAL
                     GFAHGFNIHFEFIKVPKDVDVFMVAPKGPGHLVRRTYTEGFGVPALYAVYQDATGNAKD
                     IAMDWAKGIGSARVGLLVTTFKEETEEDLFGEQAVLMGGLTHLIEAGFEVLTEAGYAPQ
                     LAYFEVLHEMKLIVDLIYEGGFKKMRQSCSNTAEFGDFVTGPRVIGPEVKENMKAALAD
                     IQSGKFAREFVEDHDAGFPRLKAYRKEAEELEIEKIGAELRKAMPFVGQNDDDAFKIYN
                     "
ORIGIN
        1 cttctgaaaa gtctagagtc ttctcaacga cttcatgtgg tgctaaagtt tgtcggaaag
       61 tctttgaata aaaagagttg agcgatagct tacggctgtc cttttgaaag agtcgccagt
      121 gatttttcaa ggctcgatag ggtagtgact tcttatcaaa ctggttcata atagcaattc
      181 ttgtctttaa aaatgctcga ccaaggtgct ggataatgtg gaaacgatca agaacgattt
      241 tggcgtttgg aaaaagtttt ttggctagtg gcatataggt cccagacata tccatcgtga
      301 taaactgtac ctgttgtcgg actttcaatg gatacttcaa aaagtagttt cgtatagtgg
      361 tttggcgacg attatcaagg atggttatga gttcgtttgt ctcttaattc tgggctacaa
      421 aagcgaattc ccctttcttg aacccaaact catcccagga cataacagta gggagcttgt
      481 cataatgttc cttgaaagta aactggtcga gcttacgata gacagtggac gtcgacacac
      541 gaagctttct ggcaatatca gttagtgaca tcttctcagt tagtagttgt gtaacctttt
      601 gtcggacaag gttggagatt tgacagtttt tctcaacgat tgatgtctca gctaccgtga
      661 ctctcctaca atttttacac tggaagcggc gtttcttcag acgtagtagt gttggagttc
      721 ccgcttgttc gagaagaggg attttagaag gcttttgaaa gtcgtacttg atcatttttc
      781 catggcaatg aggacatgat ggtgcaggat aatcgagttt tgcttgaatc tctatatgag
      841 tgtcagtttc aaaaacaagt gaaatcttga tgttttggtc tttaattccg attaattctg
      901 tggtattctt aataagtctc ataagttctt cctaatgatg gtttggttgc ttttcattat
      961 agttcttatg ggactttttg tctgcattca aaaagctcta taatctctac agtgatttta
     1021 cccactacag aaattataga gccatttttt catgtctttg agaggagaaa atagggtgat
     1081 atccgaatga ttttttcaca agtcacaaaa cgtgtagaaa tattctgaca attatgttac
     1141 aatagagcca cagactatct aaaaagagga tttaccatga cacttgtata ccaatcaaca
     1201 cgtgacgaaa ataataaagt aacagctagt caggctattc ttcaaggttt ggcaacagat
     1261 ggtggcttgt tcacaccgtt gtcaacgcct gaggttactt tgaactttga tcaattgaaa
     1321 gatgcttctt accaagaagt tgctaaatta gtcttgtcag ctttcttgga tgattttact
     1381 gaagaggaat tggattactg tatcacaaat gcttatgatg acaagtttga tacagctgcc
     1441 attgcaccag tagttaaact taagaaccac tacaaccttg aacttttcca tggttctact
     1501 atcgctttca aagacatggc cctttcaatc ttgccttact tgctaacaac atcagctaaa
     1561 aagcaaggtg ttgataataa gattgtcatc ttgacagcga catcaggtga cactggtaaa
     1621 gctgccatgg ctggttttgc agatgttcct ggaactgaaa tcattgtctt ttatccaaaa
     1681 gacggtgttt caaaaatcca agaattgcaa atgaccactc aaacaggagc taatacgcac
     1741 gttattgcca ttgatggtaa ctttgatgat gctcaaacag atgtgaaacg tatgtttaat
     1801 gatgttgatt tgcgtgagaa attgttggct catcatacgc aattctcatc agctaactca
     1861 atgaacgttg gtcgtttggt accgcaagtg gtttactatg tatatgccta tgcacagttg
     1921 gttaaggcag gtcatatcca aaacggagat aaggtgaact tcacagtacc aacaggaaac
     1981 tttggtaata tcttggcggc ttattatgca catcagattg gtgttccagt tggcaaatta
     2041 atctgtgctt ctaatgaaaa taacgtcctt acagacttct tcgcaacggg tacttatgat
     2101 aagaaacgtg acttcaaggt aacaacaagc ccttctatgg atatcttggt atcttctaac
     2161 ttggaacgtt tgattttcca ccttcttggt aatgatgcta ctaagactaa agagcttatg
     2221 gatgcacttg tgactaaggg tgagtatact ttggctgatg cagataaaga tattcttgat
     2281 ttgtttgcag caggttttgc aactgaggat gaaacagctg ctgaaatcaa gcgtgtctat
     2341 gatgaagaca agtatatcga agatcctcat acagcagttg cctcagctgt ttacgaagca
     2401 tatgttcaaa agacagatga ccacacacca acagttatcg cttcaacagc tagcccatac
     2461 aaattcccac gtgtggcagt ttcagctgtc actggtaaag acagtgggga tgatttcaaa
     2521 gcagtagaag atttgcacca actttcaggt gtagctatcc cagcggctgt agatggactt
     2581 gaacatgcag aagttcgcca taaaacagtt gttgcggcag ctgatatgca aaaagcagtt
     2641 gaaagctatc ttggtgtata agaataaaaa aataggagct gagaaatcag ccctattttt
     2701 atcaatatag aaaagaatat tatgacagaa acaaagaaaa ttctaaacat agccttgcct
     2761 gctatggccg aaaaccttct acaaatgttg atgggggttg tcgattctta cctagtggct
     2821 caggtgggta ttgtcgctat atcgggggtt tccgtagcca ataatatcat tacgatttac
     2881 caagctatct ttattgctct aggagcctca agtgccagtg tcattgccag gagtttagga
     2941 aaaggtgatg ttaaagcgac taaccgagac acttgggatg ctattattat tacccttgct
     3001 cttagtctca tccttggtct actttccatt tttggtggtg gggccattct taatctttta
     3061 ggtactgagc aatctgtgac tcaggctggt agtctctacc ttgctcttgt cggtggagga
     3121 gtggttttcc tagccttgat gaccactttt ggtaacatcc tacgggccaa gggacgacct
     3181 cgtatttcca tggtcgtcag tcttttgacc aatgttctta atgctatttt atcttcttta
     3241 gctatctttg ttggacattg ggggattgtt ggggtcgcta cagctacggt tttctctcgt
     3301 ctggttggga cagtgatact ctggcaagcg atgaaactag atgtgaagca gcttgaaatt
     3361 accaaacctt ttaatagaga gttgttgggg attgcactgc cagcagcagg tgaacgactg
     3421 atgatgcgtg ctggagatgt ggtcatcgtg gctattattg ttacctttgg tacagccgtt
     3481 gtcggtggta acgccattgg tgaaaacctc acccagttta actatatgcc tggtatggga
     3541 gtcgcaacgg ctacggttat cttggttgcc aatagtctgg gtcgagggga taagacgcag
     3601 atgaagcgta ttatacgaga gtcttattgg atttccacct tcttgatggt tctggtttca
     3661 gggagtatct tgctctttgg ccaaggatta tcaggtctct ttacagataa taaagcagct
     3721 attgcggcta gtcaggtagt tattctttat tctttccttg ggaatcctgt gacttcgggg
     3781 actttagttt acacagcagt ttggcaaggt ctgggtaagg ctaagatgcc tttctatgcg
     3841 acaactattg ggatgtggat tattcgaatt ttctcaggat acttccttgg ggtgagtctg
     3901 ggaatgggtc ttgctggtgt ctggattgca accgttgttg ataatgtatg gcgtgcgatc
     3961 ttcctctacg tgatgtaccg tcgttatctc gtaaagagaa agttttaagg ataaatactg
     4021 aggagatact cttattcaaa gggtatcttc ttcttatttt ttacaagtag gctcgaatat
     4081 ggtaaaataa gctgataaaa actttttgag gtagtaatta tgactgtaaa aatcaataca
     4141 aaagatggtc aaatcgaatt gtcagatgat gtcatcgcaa cagtagttgg cggttcagca
     4201 acagaaattt ttggcgttgt cggtatggca agtaagagtg ctatccgaga taattttcaa
     4261 gcacttcttg gaaaagaaaa ctacgcaaaa ggagttgtcg tgaaatctac tgatgcaggt
     4321 atcactgttg atgtctacac tgttatgagt tacggtgtta agattagtga ggtttcaaaa
     4381 aatattcaag aacgtgtgaa atttaatctt gagaatcaac tcggtatcaa ggctgaaaca
     4441 gtaaatgttt acgttcaaaa tattaaagtc gtaggagaaa actagtgtct aaaattacaa
     4501 caagcttgct tcaggagatg gtccaagcgg cagcaacacg tctaggtaag caagcagaat
     4561 atgtgaattc actcaatgtc ttcccagtac cagatggaga tactggaaca aacatgggaa
     4621 tgactatgga taacggagct aaagctgtcg cagatcaatc agcttcaaca gttggtgaag
     4681 ttggtcagat tttgtctaaa ggtcttttga tgggtgcccg tggtaactca ggtgttatca
     4741 cctcacaatt gttccgtgga tttggtcaaa gtatcaagga caaaacggaa cttgacggcc
     4801 aagatctagc tcatgccttc caagcagggg ttgaagttgc ttataaagct gttatgaaac
     4861 ctgttgaagg aacaatcctt acagtatcac gtggtgcagc ttcagcagcg attaagaaag
     4921 ctgaatctac aaatgatgct gttgaggtta tgcgtgcagc tctcgatgga gctaaggctg
     4981 ccttggctaa gacaccagag atgcttccag ttttgaaaga agttggtgtg gtagactcag
     5041 gtggtcaagg tttggtcttc atttatgaag gtttcttgtc agccctcaca ggtgagtata
     5101 tcgcttcaga ggacttccaa gcgacacctg ctacgatgac agagatgatc aatgcagaac
     5161 atcataagtc agttgctggt catgttgcaa cagaagacat tacttttggt tactgtacgg
     5221 aaatcatgat tggtctcaaa caaggtccaa cttatgtgaa ggactttgac tatgaagagt
     5281 tccaaaatta cttgagcaac cttggggatt ctctccttgt tgttaatgac gatgaaattg
     5341 tcaaagttca cgtccacact gaggatccag gtcttgtcat gcaagaaggt cttaaatatg
     5401 gggctcttgt caaagttaag gttgacaaca tgcgtaacca acacgatgca caagttcaaa
     5461 aagaagaagc tatccaagct gcaccttctg ctcctaaaga ctttgctctt attgcagttg
     5521 ttgctggaga tgggcttgca gatatcttca aatcacaagg tgttgactat gtgatttcag
     5581 gtggtcaaac aatgaaccca tcaacagaag atattgttaa ggctattgag caggttaatg
     5641 ctaagaatgt tatcatcttg ccaaacaata aaaacatctt tatggcagca caatcagctg
     5701 ctgaagtagt agatgtcaat gcggcagttg ttgaaacgcg tacagtacca caaggcttta
     5761 caagcttgct tgcttttgat cctagccaaa gtatcgaagc gaatgttgaa gctatgacag
     5821 ctagtctttc agatgtaaca agtggtagcg tgaccttggc ggtacgtgac acaactattg
     5881 acggacttga gattcatgaa aatgatatcc ttggtatggt tgatggtaag atccttgtgt
     5941 ctacaccaga tatggatcaa gcccttcttg acacttttga caagatgatt gacgaagaca
     6001 gtgaaattgt tatgatttat gtcggcgaag aaggtaatca agaacaagct caagcacttg
     6061 cggaaaaatt ggaagaggct cacgaaggta tcgaagttga aatcttccaa ggagaccaac
     6121 cagtttatcc atacctcttt agtgttgaat aatattgaaa taatcattta ggaagtctta
     6181 gagcttcctt tttgttttgt cagttttgat acggctggga catcttttcg aaattacaga
     6241 aatattctga aaattccttg acattacttt ccaaagtggt aacatatgtt gtaagaaatt
     6301 ttatagattg aaggtaacat catgagaagt gatatgatta aagttggtgt tgataaggca
     6361 ccagcacgcg gacttttgta tgcgactggg caagttaaat ctgccaagga tatgcaaaag
     6421 cctttcattg ctatttgtaa ctcttatatt gatattgttc cagggcatgt tcacttgcgt
     6481 gaattagcag atattgccaa ggaagctatc cgcgaggctg gcggtattcc ttttgagttt
     6541 aataccattg gtgtggatga tgggattgcc atggggcata ttgggatgcg ttacagtctt
     6601 ccatctcgtg aattgattgc cgattctgca gaaacagtta ttaatgccca ctggtttgac
     6661 ggggttttct atattcctaa ctgtgataag attacgccag ggatgatttt ggcagccatg
     6721 cgtactaatg tgccagcagt attttgttct ggtggcccta tgaagggtgg cgttgacatg
     6781 actggtcatc aagcgacgct atcaagtttg tttgaagctg taggtaccta tcaggctgga
     6841 gatatgagca aggaagagct cgattatttg gagaaaaatg cttgtccaac ttgtggttca
     6901 tgttcaggaa tgtttaccgc taactcaatg aactgtttga tggaagtttt gggtcttgcc
     6961 cttccaggta acggtactat cctagctgtc tcagatgaac gtcgtgaatt ggttcgtcaa
     7021 gcagccacaa aattgatgga taacatcaaa aataatgttc gcccacgtga tattgtgacc
     7081 aaagaagcta tcgatgatgc gtttgctctt gatatggcta tgggtggttc aaccaatact
     7141 gttctccata cccttgctat tgcgcgtgag gctggtattg attatgacct taaggacatt
     7201 aatgaaattg ccaagaagac accttatctc tctaaaattg ccccttcaag tgtttacacc
     7261 atgcatgatg tgcatgaagc tggtggtgtt ccagccatta tcaatcagtt gattaaaaag
     7321 ggagccatta agggtgatcg tattacagtt actggtaaaa ccttgaaaga aaatgtagct
     7381 ggtgctgaaa tcaaaaatga agaaattatc catccgattg agcatcctat ttcaccagtt
     7441 ggtggtttgt ctattcttta cggaaatatt gctcaggatg gagctgttat caaggttggt
     7501 ggtgtagatc catctgttaa aactttccgc ggtaaagcta tttgttgtga ttcacaagat
     7561 caagcccttg agttgattga caatggaaca gttaagaagg gacatgtcgt tgtcattcga
     7621 tacgaaggtc ctcagggtgg tcctggtatg ccagaaatgt tggcaccaac ttctaagatt
     7681 gtcggacgcg gtcttggtaa ggatgtggca ctgattacgg atggccgttt ctcaggagct
     7741 actcgtggta ttgctattgg tcacgtttct ccagaagcag cagaaggtgg taatatcgcc
     7801 ctaatcgaag atggcgatga aatcgtgatt gatcttccaa accgtactct tgatctgctt
     7861 gtcgatgatg taacccttga agaacgtcgc aaacatttga aacctttcaa atcaaaaatt
     7921 tcaagtggtt ggttgcgtcg ctatacagcc tttgctaaat cagccaatgt cggcggaact
     7981 ttgatgagtg acgaagaatt cgaagaacgt aaagcagaac gtcaagcaca agaaaaaaac
     8041 taagaacatt ctttccgaag agtttgtgat atttttctct gaaacccttg caaatttggt
     8101 taaaaatgtt atcatagtat acaaggtttt gaatttttag acaattcgaa aaaaacaact
     8161 actaaaggag gtccatgtga agaaaattga acttgaagaa gcacgctctg gtgctgattt
     8221 gattcttgat acacttcttg aacttgggat ttcaactatc tttggatatc ctggcggagc
     8281 ggttcttcct ttgtatgatg ctatttacaa aaatgacaag attaatcata tcttatctcg
     8341 tcatgagcaa ggaagtctgc acgaagctga aggttatgcc aaatcaactg gtaaactcgg
     8401 tgttgctctt gtaacgagtg gtcctggtgc cactaatgct attacaggga ttgcagatgc
     8461 tatgagtgat agcgtacctc tcctagtctt tactggtcag gtagcaacat caggtattgg
     8521 taaggatgcc ttccaagagg ctgacattgt cggaattacc atgccgatta caaaatacaa
     8581 ttatcagatt cgcgatacag ctgatattcc tcgtattatt agggaagcgg ttcatattgc
     8641 aacaactggt cgtcctggtc cagttgttat cgacctccct aaagatgtcg tagctaagga
     8701 aacagccttc atcaacgatc ctgaaattaa tcttccaagt taccaaccga cgctaagacc
     8761 aaacgaaatg caaatcaaga aaatcttgaa gcagttgggg aaagctaaga aaccggttat
     8821 tgtagctgga ggtggggtgt cttattctga atctgctaag gagctagttg cttttgcaga
     8881 acgctaccaa atcccagttg tcacaagtct tctaggacaa gggacaattg ctactagtca
     8941 tccccttttc ttgggtatgg gtggtatgca cggttcatat gcggctaaca ttgctatgac
     9001 ggatgctgac tttatgattg ctattggttg tcgttttgat gaccgtttga caggtaatcc
     9061 taaaacattt gctaagaatg ctaaggttgt ccatattgat gtagatccag ctgagattgg
     9121 taaaattatt gcagtggacc ttccagttgt tggtgatgct aagcaagctc ttgaaatgct
     9181 cttagcagaa ccagtggttc agaataacac tgaaaaatgg attgaaaaag tcacaaaaga
     9241 caaagaacgt gtacgttctt acgataagaa agaacgtatg gtacagcctc aggcagttat
     9301 cgagcgtatc ggtgaattga ctaagggtga tgccgttgtt gttactgacg ttggacaaca
     9361 tcaaatgtgg acagctcagt attatccata ccaaaatgag cgtcaactgg tgacctcagg
     9421 tggtcttgga acaatgggat tcggtgtccc agcagcaatt ggtgctaaaa ttgctaatcc
     9481 tgataaagaa gttatcctct ttgttggtga tggtggtttc caaatgacga accaagaatt
     9541 ggctatctta aatatttaca aggtgccaat caaggttgtt atgttgaaca accactcact
     9601 tggtatggta cgtcaatggc aagagtcctt ctacgaaggg cgtacatcag agtctgtctt
     9661 tgataccctc ccagatttcc aattgatggc tcaagcttac ggcattaagt cctacaagtt
     9721 tgataatcca gagacaattg atcaggattt ggaagttatc aaggaagacg taccaatgtt
     9781 catcgaggtg gatatctctc gtaaagagca tgtcttgcca atcgttccgg ctggtaagag
     9841 taatcatgaa atgttggggg tgaagttcaa tgcgtagaat gttaacagct aaacttcaga
     9901 accgttcggg tgtccttaac cgcttcacag gtgttctttc acgacgtcaa gttaatattg
     9961 aaagtatctc tgtaggggct tctgaggatc ctaacgtttc acgtattacg attattattg
    10021 atgtgaattc tcaaaatgaa gtggaacaaa tcatcaaaca gcttaatcgt cagattgatg
    10081 tgatccgtat ccgtgatatc acggatcagc cacacttgga acgtgaagtt atcctagtta
    10141 aggtatcagc accaacctct aagcgtgctg aaatcttggc gattattcaa cctttccgtg
    10201 cttcggtggt tgatgtggca ccaagctcta tcactatcca gatgactggt gatgctgaaa
    10261 agagcgaggc gcttctacga gttattcgtc cttacggaat caagaatatc gctcgtacgg
    10321 gtgctactgg atttacccgt gattaaaaaa tccaacctaa atttgttaac ccagccttaa
    10381 aaaggcaata aaatattttt tagaaaagag acatattact atggcagttc aaatggaata
    10441 tgaaaaagac gtaaaagtag cagcacttga cggtaaaaaa atcgccgtta tcggttacgg
    10501 ttcacaaggt catgcgcatg cacaaaactt gcgtgattca ggtcacgatg tgatcatcgg
    10561 tgttcgtcca ggtaaatcat ttgataaagc taaagaagat ggttttgata cttacacagt
    10621 agcagaagca actaaattgg ctgatatcat tatggttttg gcaccagatg aaattcaaaa
    10681 agatatctat aaagatgaaa ttgagccaaa cttgagtgca ggcaaagctc ttggttttgc
    10741 acacggattt aacatccact tcgaattcat caaggttcct aaagatgttg atgtctttat
    10801 ggttgctcct aaaggaccag gtcacttggt acgccgtaca tatacagaag gctttggtgt
    10861 tcctgcactt tacgcagtat accaagatgc tacaggtaat gctaaagata tcgctatgga
    10921 ctgggctaaa ggtattggtt ctgcacgtgt tggattactt gtaacaacat ttaaagaaga
    10981 aactgaagaa gatttgtttg gtgaacaagc ggttcttatg ggtgggttga cacaccttat
    11041 tgaagctggt tttgaagtct tgactgaagc aggctatgca ccacaattag cttactttga
    11101 agtgcttcac gaaatgaaat tgattgttga cttgatctac gaaggtggat tcaagaaaat
    11161 gcgtcaatca tgttcaaata ctgcagaatt tggtgacttt gtaactggtc cacgtgtcat
    11221 cggtccagaa gtcaaagaaa acatgaaagc tgcccttgct gatatccaat caggtaaatt
    11281 tgcacgtgaa ttcgttgaag accatgatgc tggcttccca cgtttgaaag cttaccgtaa
    11341 agaagctgaa gagcttgaaa ttgaaaagat tggtgctgaa ttgcgtaaag caatgccatt
    11401 cgttggtcaa aacgacgatg acgcattcaa aatctataac taatgtgata gtctcaaaaa
    11461 ccagtttagt actggttttt ttgtgttctg aagagagtag ttggtaatca atcctactgc
    11521 tcttttttgg tcttgaatat acaatataag tgcacaataa aaactcataa gattttctag
    11581 taaaatagaa ttgaacgaac tagtta
//
