LOCUS       c00018_gnlPro..        10699 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|IPGDNACK_18.
ACCESSION   c00018_gnlPro..
VERSION     c00018_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2025-04-29 10:06:44
            Original ID  :: gnl|Prokka|IPGDNACK_18
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 10699
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..10699
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[267:10534]"
                     /cutoff="10000"
                     /detection_rule="(TPP_enzyme_C and not (PFL-like or
                     PFL_6_pcresol or PFL_9_tma or Gly_radical or Gly_430_pcre
                     or Gly_8-9_TMA or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and
                     minimum(2, [ALS_ss_C, AlaDh_PNT_C, Arginase, BKACE,
                     BcrAD_BadFG, Beta_elim_lyase, CPSase_L_D2, Cys_Met_Meta_PP,
                     ELFV_dehydrog, GRDB, Glu_syn_central, Glu_synthase,
                     Gly_reductase, HAAA1, HG2B1, HG2B2, HGD-D, HleuD1, HleuD2,
                     HleuS1, HleuS2, Homoserine_dh, ILVD_EDD, IlvC,
                     Lactoyl-CoA1, Lactoyl-CoA2, Lyase_aromatic, MAAL_C,
                     OKR_DC_1_5_lysine, OKR_DC_1_5_ornithine,
                     OKR_DC_1_7_arginine, OKR_DC_1_C, OTCace, PALP,
                     Proline_reductase, Sacchrp_dh_C, TPL, Thr_dehydrat_C, TnaA,
                     Urocanase]) and not (POR or POR_N or PFOR_II))"
                     /neighbourhood="10000"
                     /product="TPP_AA_metabolism"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      268..10534
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(TPP_enzyme_C and not (PFL-like or
                     PFL_6_pcresol or PFL_9_tma or Gly_radical or Gly_430_pcre
                     or Gly_8-9_TMA or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and
                     minimum(2, [ALS_ss_C, AlaDh_PNT_C, Arginase, BKACE,
                     BcrAD_BadFG, Beta_elim_lyase, CPSase_L_D2, Cys_Met_Meta_PP,
                     ELFV_dehydrog, GRDB, Glu_syn_central, Glu_synthase,
                     Gly_reductase, HAAA1, HG2B1, HG2B2, HGD-D, HleuD1, HleuD2,
                     HleuS1, HleuS2, Homoserine_dh, ILVD_EDD, IlvC,
                     Lactoyl-CoA1, Lactoyl-CoA2, Lyase_aromatic, MAAL_C,
                     OKR_DC_1_5_lysine, OKR_DC_1_5_ornithine,
                     OKR_DC_1_7_arginine, OKR_DC_1_C, OTCace, PALP,
                     Proline_reductase, Sacchrp_dh_C, TPL, Thr_dehydrat_C, TnaA,
                     Urocanase]) and not (POR or POR_N or PFOR_II))"
                     /neighbourhood="10000"
                     /product="TPP_AA_metabolism"
                     /protocluster_number="1"
     cand_cluster    1..10699
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(TPP_enzyme_C and not (PFL-like or
                     PFL_6_pcresol or PFL_9_tma or Gly_radical or Gly_430_pcre
                     or Gly_8-9_TMA or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and
                     minimum(2, [ALS_ss_C, AlaDh_PNT_C, Arginase, BKACE,
                     BcrAD_BadFG, Beta_elim_lyase, CPSase_L_D2, Cys_Met_Meta_PP,
                     ELFV_dehydrog, GRDB, Glu_syn_central, Glu_synthase,
                     Gly_reductase, HAAA1, HG2B1, HG2B2, HGD-D, HleuD1, HleuD2,
                     HleuS1, HleuS2, Homoserine_dh, ILVD_EDD, IlvC,
                     Lactoyl-CoA1, Lactoyl-CoA2, Lyase_aromatic, MAAL_C,
                     OKR_DC_1_5_lysine, OKR_DC_1_5_ornithine,
                     OKR_DC_1_7_arginine, OKR_DC_1_C, OTCace, PALP,
                     Proline_reductase, Sacchrp_dh_C, TPL, Thr_dehydrat_C, TnaA,
                     Urocanase]) and not (POR or POR_N or PFOR_II))"
                     /kind="single"
                     /product="TPP_AA_metabolism"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..10699
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="TPP_AA_metabolism"
                     /region_number="1"
                     /rules="(TPP_enzyme_C and not (PFL-like or PFL_6_pcresol or
                     PFL_9_tma or Gly_radical or Gly_430_pcre or Gly_8-9_TMA or
                     PFL_acetate1 or PFL_acetate2 or Gly_radical_scatole or
                     PFL_proline or PFL_toluene) and minimum(2, [ALS_ss_C,
                     AlaDh_PNT_C, Arginase, BKACE, BcrAD_BadFG, Beta_elim_lyase,
                     CPSase_L_D2, Cys_Met_Meta_PP, ELFV_dehydrog, GRDB,
                     Glu_syn_central, Glu_synthase, Gly_reductase, HAAA1, HG2B1,
                     HG2B2, HGD-D, HleuD1, HleuD2, HleuS1, HleuS2,
                     Homoserine_dh, ILVD_EDD, IlvC, Lactoyl-CoA1, Lactoyl-CoA2,
                     Lyase_aromatic, MAAL_C, OKR_DC_1_5_lysine,
                     OKR_DC_1_5_ornithine, OKR_DC_1_7_arginine, OKR_DC_1_C,
                     OTCace, PALP, Proline_reductase, Sacchrp_dh_C, TPL,
                     Thr_dehydrat_C, TnaA, Urocanase]) and not (POR or POR_N or
                     PFOR_II))"
                     /tool="gutsmash"
     CDS             268..1752
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: PALP"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg18_1"
                     /sec_met_domain="PALP (E-value: 1.6e-17, bitscore: 52.8,
                     seeds: 146, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTLVYQSTRDENNKVTASQAILQGLATDGGLFTPLSTPEVTLNFD
                     QLKDASYQEVAKLVLSAFLDDFTEEELDYCITNAYDDKFDTAAIAPVVKLKNHYNLELF
                     HGSTIAFKDMALSILPYLLTTSAKKQGVDNKIVILTATSGDTGKAAMAGFADVPGTEII
                     VFYPKDGVSKIQELQMTTQTGANTHVIAIDGNFDDAQTDVKRMFNDVDLREKLLAHHTQ
                     FSSANSMNVGRLVPQVVYYVYAYAQLVKAGHIQNGDKVNFTVPTGNFGNILAAYYAHQI
                     GVPVGKLICASNENNVLTDFFATGTYDKKRDFKVTTSPSMDILVSSNLERLIFHLLGND
                     ATKTKELMDALVTKGEYTLADADKDILDLFAAGFATEDETAAEIKRVYDEDKYIEDPHT
                     AVASAVYEAYVQKTDDHTPTVIASTASPYKFPRVAVSAVTGKDSGDDFKAVEDLHQLSG
                     VAIPAAVDGLEHAEVRHKTVVAAADMQKAVESYLGV"
     CDS             1813..3099
                     /locus_tag="ctg18_2"
                     /transl_table=11
                     /translation="MTETKKILNIALPAMAENLLQMLMGVVDSYLVAQVGIVAISGVSV
                     ANNIITIYQAIFIALGASSASVIARSLGKGDVKATNRDTWDAIIITLALSLILGLLSIF
                     GGGAILNLLGTEQSVTQAGSLYLALVGGGVVFLALMTTFGNILRAKGRPRISMVVSLLT
                     NVLNAILSSLAIFVGHWGIVGVATATVFSRLVGTVILWQAMKLDVKQLEITKPFNRELL
                     GIALPAAGERLMMRAGDVVIVAIIVTFGTAVVGGNAIGENLTQFNYMPGMGVATATVIL
                     VANSLGRGDKTQMKRIIRESYWISTFLMVLVSGSILLFGQGLSGLFTDNKAAIAASQVV
                     ILYSFLGNPVTSGTLVYTAVWQGLGKAKMPFYATTIGMWIIRIFSGYFLGVSLGMGLAG
                     VWIATVVDNVWRAIFLYVMYRRYLVKRKF"
     CDS             3211..3576
                     /locus_tag="ctg18_3"
                     /transl_table=11
                     /translation="MTVKINTKDGQIELSDDVIATVVGGSATEIFGVVGMASKSAIRDN
                     FQALLGKENYAKGVVVKSTDAGITVDVYTVMSYGVKISEVSKNIQERVKFNLENQLGIK
                     AETVNVYVQNIKVVGEN"
     CDS             3576..5243
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Dak2"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg18_4"
                     /sec_met_domain="Dak2 (E-value: 1.9e-44, bitscore: 140.7,
                     seeds: 138, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="VSKITTSLLQEMVQAAATRLGKQAEYVNSLNVFPVPDGDTGTNMG
                     MTMDNGAKAVADQSASTVGEVGQILSKGLLMGARGNSGVITSQLFRGFGQSIKDKTELD
                     GQDLAHAFQAGVEVAYKAVMKPVEGTILTVSRGAASAAIKKAESTNDAVEVMRAALDGA
                     KAALAKTPEMLPVLKEVGVVDSGGQGLVFIYEGFLSALTGEYIASEDFQATPATMTEMI
                     NAEHHKSVAGHVATEDITFGYCTEIMIGLKQGPTYVKDFDYEEFQNYLSNLGDSLLVVN
                     DDEIVKVHVHTEDPGLVMQEGLKYGALVKVKVDNMRNQHDAQVQKEEAIQAAPSAPKDF
                     ALIAVVAGDGLADIFKSQGVDYVISGGQTMNPSTEDIVKAIEQVNAKNVIILPNNKNIF
                     MAAQSAAEVVDVNAAVVETRTVPQGFTSLLAFDPSQSIEANVEAMTASLSDVTSGSVTL
                     AVRDTTIDGLEIHENDILGMVDGKILVSTPDMDQALLDTFDKMIDEDSEIVMIYVGEEG
                     NQEQAQALAEKLEEAHEGIEVEIFQGDQPVYPYLFSVE"
     CDS             5413..7134
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: ILVD_EDD"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg18_5"
                     /sec_met_domain="ILVD_EDD (E-value: 2.3e-225, bitscore:
                     738.1, seeds: 918, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRSDMIKVGVDKAPARGLLYATGQVKSAKDMQKPFIAICNSYIDI
                     VPGHVHLRELADIAKEAIREAGGIPFEFNTIGVDDGIAMGHIGMRYSLPSRELIADSAE
                     TVINAHWFDGVFYIPNCDKITPGMILAAMRTNVPAVFCSGGPMKGGVDMTGHQATLSSL
                     FEAVGTYQAGDMSKEELDYLEKNACPTCGSCSGMFTANSMNCLMEVLGLALPGNGTILA
                     VSDERRELVRQAATKLMDNIKNNVRPRDIVTKEAIDDAFALDMAMGGSTNTVLHTLAIA
                     REAGIDYDLKDINEIAKKTPYLSKIAPSSVYTMHDVHEAGGVPAIINQLIKKGAIKGDR
                     ITVTGKTLKENVAGAEIKNEEIIHPIEHPISPVGGLSILYGNIAQDGAVIKVGGVDPSV
                     KTFRGKAICCDSQDQALELIDNGTVKKGHVVVIRYEGPQGGPGMPEMLAPTSKIVGRGL
                     GKDVALITDGRFSGATRGIAIGHVSPEAAEGGNIALIEDGDEIVIDLPNRTLDLLVDDV
                     TLEERRKHLKPFKSKISSGWLRRYTAFAKSANVGGTLMSDEEFEERKAERQAQEKN"
     CDS             7268..8968
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: TPP_enzyme_C"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg18_6"
                     /sec_met_domain="TPP_enzyme_C (E-value: 9.1e-49, bitscore:
                     154.3, seeds: 323, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="VKKIELEEARSGADLILDTLLELGISTIFGYPGGAVLPLYDAIYK
                     NDKINHILSRHEQGSLHEAEGYAKSTGKLGVALVTSGPGATNAITGIADAMSDSVPLLV
                     FTGQVATSGIGKDAFQEADIVGITMPITKYNYQIRDTADIPRIIREAVHIATTGRPGPV
                     VIDLPKDVVAKETAFINDPEINLPSYQPTLRPNEMQIKKILKQLGKAKKPVIVAGGGVS
                     YSESAKELVAFAERYQIPVVTSLLGQGTIATSHPLFLGMGGMHGSYAANIAMTDADFMI
                     AIGCRFDDRLTGNPKTFAKNAKVVHIDVDPAEIGKIIAVDLPVVGDAKQALEMLLAEPV
                     VQNNTEKWIEKVTKDKERVRSYDKKERMVQPQAVIERIGELTKGDAVVVTDVGQHQMWT
                     AQYYPYQNERQLVTSGGLGTMGFGVPAAIGAKIANPDKEVILFVGDGGFQMTNQELAIL
                     NIYKVPIKVVMLNNHSLGMVRQWQESFYEGRTSESVFDTLPDFQLMAQAYGIKSYKFDN
                     PETIDQDLEVIKEDVPMFIEVDISRKEHVLPIVPAGKSNHEMLGVKFNA"
     CDS             8961..9437
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: ALS_ss_C"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg18_7"
                     /sec_met_domain="ALS_ss_C (E-value: 2.8e-29, bitscore:
                     90.4, seeds: 685, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRRMLTAKLQNRSGVLNRFTGVLSRRQVNIESISVGASEDPNVSR
                     ITIIIDVNSQNEVEQIIKQLNRQIDVIRIRDITDQPHLEREVILVKVSAPTSKRAEILA
                     IIQPFRASVVDVAPSSITIQMTGDAEKSEALLRVIRPYGIKNIARTGATGFTRD"
     CDS             9512..10534
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: IlvC"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) IlvN"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg18_8"
                     /sec_met_domain="IlvN (E-value: 7.7e-81, bitscore: 258.6,
                     seeds: 43, tool: rule-based-clusters)"
                     /sec_met_domain="IlvC (E-value: 1.4e-63, bitscore: 202.6,
                     seeds: 295, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAVQMEYEKDVKVAALDGKKIAVIGYGSQGHAHAQNLRDSGHDVI
                     IGVRPGKSFDKAKEDGFDTYTVAEATKLADIIMVLAPDEIQKDIYKDEIEPNLSAGKAL
                     GFAHGFNIHFEFIKVPKDVDVFMVAPKGPGHLVRRTYTEGFGVPALYAVYQDATGNAKD
                     IAMDWAKGIGSARVGLLVTTFKEETEEDLFGEQAVLMGGLTHLIEAGFEVLTEAGYAPQ
                     LAYFEVLHEMKLIVDLIYEGGFKKMRQSCSNTAEFGDFVTGPRVIGPEVKENMKAALAD
                     IQSGKFAREFVEDHDAGFPRLKAYRKEAEELEIEKIGAELRKAMPFVGQNDDDAFKIYN
                     "
ORIGIN
        1 taataagtct cataagttct tcctaatgat ggtttggttg cttttcatta tagttcttat
       61 gggacttttt gtctgcattc aaaaagctct ataatctcta cagtgatttt acccactaca
      121 gaaattatag agccattttt tcatgtcttt gagaggagaa aatagggtga tatccgaatg
      181 attttttcac aagtcacaaa acgtgtagaa atattctgac aattatgtta caatagagcc
      241 acagactatc taaaaagagg atttaccatg acacttgtat accaatcaac acgtgacgaa
      301 aataataaag taacagctag tcaggctatt cttcaaggtt tggcaacaga tggtggcttg
      361 ttcacaccgt tgtcaacgcc tgaggttact ttgaactttg atcaattgaa agatgcttct
      421 taccaagaag ttgctaaatt agtcttgtca gctttcttgg atgattttac tgaagaggaa
      481 ttggattact gtatcacaaa tgcttatgat gacaagtttg atacagctgc cattgcacca
      541 gtagttaaac ttaagaacca ctacaacctt gaacttttcc atggttctac tatcgctttc
      601 aaagacatgg ccctttcaat cttgccttac ttgctaacaa catcagctaa aaagcaaggt
      661 gttgataata agattgtcat cttgacagcg acatcaggtg acactggtaa agctgccatg
      721 gctggttttg cagatgttcc tggaactgaa atcattgtct tttatccaaa agacggtgtt
      781 tcaaaaatcc aagaattgca aatgaccact caaacaggag ctaatacgca cgttattgcc
      841 attgatggta actttgatga tgctcaaaca gatgtgaaac gtatgtttaa tgatgttgat
      901 ttgcgtgaga aattgttggc tcatcatacg caattctcat cagctaactc aatgaacgtt
      961 ggtcgtttgg taccgcaagt ggtttactat gtatatgcct atgcacagtt ggttaaggca
     1021 ggtcatatcc aaaacggaga taaggtgaac ttcacagtac caacaggaaa ctttggtaat
     1081 atcttggcgg cttattatgc acatcagatt ggtgttccag ttggcaaatt aatctgtgct
     1141 tctaatgaaa ataacgtcct tacagacttc ttcgcaacgg gtacttatga taagaaacgt
     1201 gacttcaagg taacaacaag cccttctatg gatatcttgg tatcttctaa cttggaacgt
     1261 ttgattttcc accttcttgg taatgatgct actaagacta aagagcttat ggatgcactt
     1321 gtgactaagg gtgagtatac tttggctgat gcagataaag atattcttga tttgtttgca
     1381 gcaggttttg caactgagga tgaaacagct gctgaaatca agcgtgtcta tgatgaagac
     1441 aagtatatcg aagatcctca tacagcagtt gcctcagctg tttacgaagc atatgttcaa
     1501 aagacagatg accacacacc aacagttatc gcttcaacag ctagcccata caaattccca
     1561 cgtgtggcag tttcagctgt cactggtaaa gacagtgggg atgatttcaa agcagtagaa
     1621 gatttgcacc aactttcagg tgtagctatc ccagcggctg tagatggact tgaacatgca
     1681 gaagttcgcc ataaaacagt tgttgcggca gctgatatgc aaaaagcagt tgaaagctat
     1741 cttggtgtat aagaataaaa aaataggagc tgagaaatca gccctatttt tatcaatata
     1801 gaaaagaata ttatgacaga aacaaagaaa attctaaaca tagccttgcc tgctatggcc
     1861 gaaaaccttc tacaaatgtt gatgggggtt gtcgattctt acctagtggc tcaggtgggt
     1921 attgtcgcta tatcgggggt ttccgtagcc aataatatca ttacgattta ccaagctatc
     1981 tttattgctc taggagcctc aagtgccagt gtcattgcca ggagtttagg aaaaggtgat
     2041 gttaaagcga ctaaccgaga cacttgggat gctattatta ttacccttgc tcttagtctc
     2101 atccttggtc tactttccat ttttggtggt ggggccattc ttaatctttt aggtactgag
     2161 caatctgtga ctcaggctgg tagtctctac cttgctcttg tcggtggagg agtggttttc
     2221 ctagccttga tgaccacttt tggtaacatc ctacgggcca agggacgacc tcgtatttcc
     2281 atggtcgtca gtcttttgac caatgttctt aatgctattt tatcttcttt agctatcttt
     2341 gttggacatt gggggattgt tggggtcgct acagctacgg ttttctctcg tctggttggg
     2401 acagtgatac tctggcaagc gatgaaacta gatgtgaagc agcttgaaat taccaaacct
     2461 tttaatagag agttgttggg gattgcactg ccagcagcag gtgaacgact gatgatgcgt
     2521 gctggagatg tggtcatcgt ggctattatt gttacctttg gtacagccgt tgtcggtggt
     2581 aacgccattg gtgaaaacct cacccagttt aactatatgc ctggtatggg agtcgcaacg
     2641 gctacggtta tcttggttgc caatagtctg ggtcgagggg ataagacgca gatgaagcgt
     2701 attatacgag agtcttattg gatttccacc ttcttgatgg ttctggtttc agggagtatc
     2761 ttgctctttg gccaaggatt atcaggtctc tttacagata ataaagcagc tattgcggct
     2821 agtcaggtag ttattcttta ttctttcctt gggaatcctg tgacttcggg gactttagtt
     2881 tacacagcag tttggcaagg tctgggtaag gctaagatgc ctttctatgc gacaactatt
     2941 gggatgtgga ttattcgaat tttctcagga tacttccttg gggtgagtct gggaatgggt
     3001 cttgctggtg tctggattgc aaccgttgtt gataatgtat ggcgtgcgat cttcctctac
     3061 gtgatgtacc gtcgttatct cgtaaagaga aagttttaag gataaatact gaggagatac
     3121 tcttattcaa agggtatctt cttcttattt tttacaagta ggctcgaata tggtaaaata
     3181 agctgataaa aactttttga ggtagtaatt atgactgtaa aaatcaatac aaaagatggt
     3241 caaatcgaat tgtcagatga tgtcatcgca acagtagttg gcggttcagc aacagaaatt
     3301 tttggcgttg tcggtatggc aagtaagagt gctatccgag ataattttca agcacttctt
     3361 ggaaaagaaa actacgcaaa aggagttgtc gtgaaatcta ctgatgcagg tatcactgtt
     3421 gatgtctaca ctgttatgag ttacggtgtt aagattagtg aggtttcaaa aaatattcaa
     3481 gaacgtgtga aatttaatct tgagaatcaa ctcggtatca aggctgaaac agtaaatgtt
     3541 tacgttcaaa atattaaagt cgtaggagaa aactagtgtc taaaattaca acaagcttgc
     3601 ttcaggagat ggtccaagcg gcagcaacac gtctaggtaa gcaagcagaa tatgtgaatt
     3661 cactcaatgt cttcccagta ccagatggag atactggaac aaacatggga atgactatgg
     3721 ataacggagc taaagctgtc gcagatcaat cagcttcaac agttggtgaa gttggtcaga
     3781 ttttgtctaa aggtcttttg atgggtgccc gtggtaactc aggtgttatc acctcacaat
     3841 tgttccgtgg atttggtcaa agtatcaagg acaaaacgga acttgacggc caagatctag
     3901 ctcatgcctt ccaagcaggg gttgaagttg cttataaagc tgttatgaaa cctgttgaag
     3961 gaacaatcct tacagtatca cgtggtgcag cttcagcagc gattaagaaa gctgaatcta
     4021 caaatgatgc tgttgaggtt atgcgtgcag ctctcgatgg agctaaggct gccttggcta
     4081 agacaccaga gatgcttcca gttttgaaag aagttggtgt ggtagactca ggtggtcaag
     4141 gtttggtctt catttatgaa ggtttcttgt cagccctcac aggtgagtat atcgcttcag
     4201 aggacttcca agcgacacct gctacgatga cagagatgat caatgcagaa catcataagt
     4261 cagttgctgg tcatgttgca acagaagaca ttacttttgg ttactgtacg gaaatcatga
     4321 ttggtctcaa acaaggtcca acttatgtga aggactttga ctatgaagag ttccaaaatt
     4381 acttgagcaa ccttggggat tctctccttg ttgttaatga cgatgaaatt gtcaaagttc
     4441 acgtccacac tgaggatcca ggtcttgtca tgcaagaagg tcttaaatat ggggctcttg
     4501 tcaaagttaa ggttgacaac atgcgtaacc aacacgatgc acaagttcaa aaagaagaag
     4561 ctatccaagc tgcaccttct gctcctaaag actttgctct tattgcagtt gttgctggag
     4621 atgggcttgc agatatcttc aaatcacaag gtgttgacta tgtgatttca ggtggtcaaa
     4681 caatgaaccc atcaacagaa gatattgtta aggctattga gcaggttaat gctaagaatg
     4741 ttatcatctt gccaaacaat aaaaacatct ttatggcagc acaatcagct gctgaagtag
     4801 tagatgtcaa tgcggcagtt gttgaaacgc gtacagtacc acaaggcttt acaagcttgc
     4861 ttgcttttga tcctagccaa agtatcgaag cgaatgttga agctatgaca gctagtcttt
     4921 cagatgtaac aagtggtagc gtgaccttgg cggtacgtga cacaactatt gacggacttg
     4981 agattcatga aaatgatatc cttggtatgg ttgatggtaa gatccttgtg tctacaccag
     5041 atatggatca agcccttctt gacacttttg acaagatgat tgacgaagac agtgaaattg
     5101 ttatgattta tgtcggcgaa gaaggtaatc aagaacaagc tcaagcactt gcggaaaaat
     5161 tggaagaggc tcacgaaggt atcgaagttg aaatcttcca aggagaccaa ccagtttatc
     5221 catacctctt tagtgttgaa taatattgaa ataatcattt aggaagtctt agagcttcct
     5281 ttttgttttg tcagttttga tacggctggg acatcttttc gaaattacag aaatattctg
     5341 aaaattcctt gacattactt tccaaagtgg taacatatgt tgtaagaaat tttatagatt
     5401 gaaggtaaca tcatgagaag tgatatgatt aaagttggtg ttgataaggc accagcacgc
     5461 ggacttttgt atgcgactgg gcaagttaaa tctgccaagg atatgcaaaa gcctttcatt
     5521 gctatttgta actcttatat tgatattgtt ccagggcatg ttcacttgcg tgaattagca
     5581 gatattgcca aggaagctat ccgcgaggct ggcggtattc cttttgagtt taataccatt
     5641 ggtgtggatg atgggattgc catggggcat attgggatgc gttacagtct tccatctcgt
     5701 gaattgattg ccgattctgc agaaacagtt attaatgccc actggtttga cggggttttc
     5761 tatattccta actgtgataa gattacgcca gggatgattt tggcagccat gcgtactaat
     5821 gtgccagcag tattttgttc tggtggccct atgaagggtg gcgttgacat gactggtcat
     5881 caagcgacgc tatcaagttt gtttgaagct gtaggtacct atcaggctgg agatatgagc
     5941 aaggaagagc tcgattattt ggagaaaaat gcttgtccaa cttgtggttc atgttcagga
     6001 atgtttaccg ctaactcaat gaactgtttg atggaagttt tgggtcttgc ccttccaggt
     6061 aacggtacta tcctagctgt ctcagatgaa cgtcgtgaat tggttcgtca agcagccaca
     6121 aaattgatgg ataacatcaa aaataatgtt cgcccacgtg atattgtgac caaagaagct
     6181 atcgatgatg cgtttgctct tgatatggct atgggtggtt caaccaatac tgttctccat
     6241 acccttgcta ttgcgcgtga ggctggtatt gattatgacc ttaaggacat taatgaaatt
     6301 gccaagaaga caccttatct ctctaaaatt gccccttcaa gtgtttacac catgcatgat
     6361 gtgcatgaag ctggtggtgt tccagccatt atcaatcagt tgattaaaaa gggagccatt
     6421 aagggtgatc gtattacagt tactggtaaa accttgaaag aaaatgtagc tggtgctgaa
     6481 atcaaaaatg aagaaattat ccatccgatt gagcatccta tttcaccagt tggtggtttg
     6541 tctattcttt acggaaatat tgctcaggat ggagctgtta tcaaggttgg tggtgtagat
     6601 ccatctgtta aaactttccg cggtaaagct atttgttgtg attcacaaga tcaagccctt
     6661 gagttgattg acaatggaac agttaagaag ggacatgtcg ttgtcattcg atacgaaggt
     6721 cctcagggtg gtcctggtat gccagaaatg ttggcaccaa cttctaagat tgtcggacgc
     6781 ggtcttggta aggatgtggc actgattacg gatggccgtt tctcaggagc tactcgtggt
     6841 attgctattg gtcacgtttc tccagaagca gcagaaggtg gtaatatcgc cctaatcgaa
     6901 gatggcgatg aaatcgtgat tgatcttcca aaccgtactc ttgatctgct tgtcgatgat
     6961 gtaacccttg aagaacgtcg caaacatttg aaacctttca aatcaaaaat ttcaagtggt
     7021 tggttgcgtc gctatacagc ctttgctaaa tcagccaatg tcggcggaac tttgatgagt
     7081 gacgaagaat tcgaagaacg taaagcagaa cgtcaagcac aagaaaaaaa ctaagaacat
     7141 tctttccgaa gagtttgtga tatttttctc tgaaaccctt gcaaatttgg ttaaaaatgt
     7201 tatcatagta tacaaggttt tgaattttta gacaattcga aaaaaacaac tactaaagga
     7261 ggtccatgtg aagaaaattg aacttgaaga agcacgctct ggtgctgatt tgattcttga
     7321 tacacttctt gaacttggga tttcaactat ctttggatat cctggcggag cggttcttcc
     7381 tttgtatgat gctatttaca aaaatgacaa gattaatcat atcttatctc gtcatgagca
     7441 aggaagtctg cacgaagctg aaggttatgc caaatcaact ggtaaactcg gtgttgctct
     7501 tgtaacgagt ggtcctggtg ccactaatgc tattacaggg attgcagatg ctatgagtga
     7561 tagcgtacct ctcctagtct ttactggtca ggtagcaaca tcaggtattg gtaaggatgc
     7621 cttccaagag gctgacattg tcggaattac catgccgatt acaaaataca attatcagat
     7681 tcgcgataca gctgatattc ctcgtattat tagggaagcg gttcatattg caacaactgg
     7741 tcgtcctggt ccagttgtta tcgacctccc taaagatgtc gtagctaagg aaacagcctt
     7801 catcaacgat cctgaaatta atcttccaag ttaccaaccg acgctaagac caaacgaaat
     7861 gcaaatcaag aaaatcttga agcagttggg gaaagctaag aaaccggtta ttgtagctgg
     7921 aggtggggtg tcttattctg aatctgctaa ggagctagtt gcttttgcag aacgctacca
     7981 aatcccagtt gtcacaagtc ttctaggaca agggacaatt gctactagtc atcccctttt
     8041 cttgggtatg ggtggtatgc acggttcata tgcggctaac attgctatga cggatgctga
     8101 ctttatgatt gctattggtt gtcgttttga tgaccgtttg acaggtaatc ctaaaacatt
     8161 tgctaagaat gctaaggttg tccatattga tgtagatcca gctgagattg gtaaaattat
     8221 tgcagtggac cttccagttg ttggtgatgc taagcaagct cttgaaatgc tcttagcaga
     8281 accagtggtt cagaataaca ctgaaaaatg gattgaaaaa gtcacaaaag acaaagaacg
     8341 tgtacgttct tacgataaga aagaacgtat ggtacagcct caggcagtta tcgagcgtat
     8401 cggtgaattg actaagggtg atgccgttgt tgttactgac gttggacaac atcaaatgtg
     8461 gacagctcag tattatccat accaaaatga gcgtcaactg gtgacctcag gtggtcttgg
     8521 aacaatggga ttcggtgtcc cagcagcaat tggtgctaaa attgctaatc ctgataaaga
     8581 agttatcctc tttgttggtg atggtggttt ccaaatgacg aaccaagaat tggctatctt
     8641 aaatatttac aaggtgccaa tcaaggttgt tatgttgaac aaccactcac ttggtatggt
     8701 acgtcaatgg caagagtcct tctacgaagg gcgtacatca gagtctgtct ttgataccct
     8761 cccagatttc caattgatgg ctcaagctta cggcattaag tcctacaagt ttgataatcc
     8821 agagacaatt gatcaggatt tggaagttat caaggaagac gtaccaatgt tcatcgaggt
     8881 ggatatctct cgtaaagagc atgtcttgcc aatcgttccg gctggtaaga gtaatcatga
     8941 aatgttgggg gtgaagttca atgcgtagaa tgttaacagc taaacttcag aaccgttcgg
     9001 gtgtccttaa ccgcttcaca ggtgttcttt cacgacgtca agttaatatt gaaagtatct
     9061 ctgtaggggc ttctgaggat cctaacgttt cacgtattac gattattatt gatgtgaatt
     9121 ctcaaaatga agtggaacaa atcatcaaac agcttaatcg tcagattgat gtgatccgta
     9181 tccgtgatat cacggatcag ccacacttgg aacgtgaagt tatcctagtt aaggtatcag
     9241 caccaacctc taagcgtgct gaaatcttgg cgattattca acctttccgt gcttcggtgg
     9301 ttgatgtggc accaagctct atcactatcc agatgactgg tgatgctgaa aagagcgagg
     9361 cgcttctacg agttattcgt ccttacggaa tcaagaatat cgctcgtacg ggtgctactg
     9421 gatttacccg tgattaaaaa atccaaccta aatttgttaa cccagcctta aaaaggcaat
     9481 aaaatatttt ttagaaaaga gacatattac tatggcagtt caaatggaat atgaaaaaga
     9541 cgtaaaagta gcagcacttg acggtaaaaa aatcgccgtt atcggttacg gttcacaagg
     9601 tcatgcgcat gcacaaaact tgcgtgattc aggtcacgat gtgatcatcg gtgttcgtcc
     9661 aggtaaatca tttgataaag ctaaagaaga tggttttgat acttacacag tagcagaagc
     9721 aactaaattg gctgatatca ttatggtttt ggcaccagat gaaattcaaa aagatatcta
     9781 taaagatgaa attgagccaa acttgagtgc aggcaaagct cttggttttg cacacggatt
     9841 taacatccac ttcgaattca tcaaggttcc taaagatgtt gatgtcttta tggttgctcc
     9901 taaaggacca ggtcacttgg tacgccgtac atatacagaa ggctttggtg ttcctgcact
     9961 ttacgcagta taccaagatg ctacaggtaa tgctaaagat atcgctatgg actgggctaa
    10021 aggtattggt tctgcacgtg ttggattact tgtaacaaca tttaaagaag aaactgaaga
    10081 agatttgttt ggtgaacaag cggttcttat gggtgggttg acacacctta ttgaagctgg
    10141 ttttgaagtc ttgactgaag caggctatgc accacaatta gcttactttg aagtgcttca
    10201 cgaaatgaaa ttgattgttg acttgatcta cgaaggtgga ttcaagaaaa tgcgtcaatc
    10261 atgttcaaat actgcagaat ttggtgactt tgtaactggt ccacgtgtca tcggtccaga
    10321 agtcaaagaa aacatgaaag ctgcccttgc tgatatccaa tcaggtaaat ttgcacgtga
    10381 attcgttgaa gaccatgatg ctggcttccc acgtttgaaa gcttaccgta aagaagctga
    10441 agagcttgaa attgaaaaga ttggtgctga attgcgtaaa gcaatgccat tcgttggtca
    10501 aaacgacgat gacgcattca aaatctataa ctaatgtgat agtctcaaaa accagtttag
    10561 tactggtttt tttgtgttct gaagagagta gttggtaatc aatcctactg ctcttttttg
    10621 gtcttgaata tacaatataa gtgcacaata aaaactcata agattttcta gtaaaataga
    10681 attgaacgaa ctagttacg
//
