LOCUS       c00016_gnlPro..        10734 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|JPOMIHPE_16.
ACCESSION   c00016_gnlPro..
VERSION     c00016_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2025-04-29 09:50:02
            Original ID  :: gnl|Prokka|JPOMIHPE_16
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 10734
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..10734
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[304:10571]"
                     /cutoff="10000"
                     /detection_rule="(TPP_enzyme_C and not (PFL-like or
                     PFL_6_pcresol or PFL_9_tma or Gly_radical or Gly_430_pcre
                     or Gly_8-9_TMA or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and
                     minimum(2, [ALS_ss_C, AlaDh_PNT_C, Arginase, BKACE,
                     BcrAD_BadFG, Beta_elim_lyase, CPSase_L_D2, Cys_Met_Meta_PP,
                     ELFV_dehydrog, GRDB, Glu_syn_central, Glu_synthase,
                     Gly_reductase, HAAA1, HG2B1, HG2B2, HGD-D, HleuD1, HleuD2,
                     HleuS1, HleuS2, Homoserine_dh, ILVD_EDD, IlvC,
                     Lactoyl-CoA1, Lactoyl-CoA2, Lyase_aromatic, MAAL_C,
                     OKR_DC_1_5_lysine, OKR_DC_1_5_ornithine,
                     OKR_DC_1_7_arginine, OKR_DC_1_C, OTCace, PALP,
                     Proline_reductase, Sacchrp_dh_C, TPL, Thr_dehydrat_C, TnaA,
                     Urocanase]) and not (POR or POR_N or PFOR_II))"
                     /neighbourhood="10000"
                     /product="TPP_AA_metabolism"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      305..10571
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(TPP_enzyme_C and not (PFL-like or
                     PFL_6_pcresol or PFL_9_tma or Gly_radical or Gly_430_pcre
                     or Gly_8-9_TMA or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and
                     minimum(2, [ALS_ss_C, AlaDh_PNT_C, Arginase, BKACE,
                     BcrAD_BadFG, Beta_elim_lyase, CPSase_L_D2, Cys_Met_Meta_PP,
                     ELFV_dehydrog, GRDB, Glu_syn_central, Glu_synthase,
                     Gly_reductase, HAAA1, HG2B1, HG2B2, HGD-D, HleuD1, HleuD2,
                     HleuS1, HleuS2, Homoserine_dh, ILVD_EDD, IlvC,
                     Lactoyl-CoA1, Lactoyl-CoA2, Lyase_aromatic, MAAL_C,
                     OKR_DC_1_5_lysine, OKR_DC_1_5_ornithine,
                     OKR_DC_1_7_arginine, OKR_DC_1_C, OTCace, PALP,
                     Proline_reductase, Sacchrp_dh_C, TPL, Thr_dehydrat_C, TnaA,
                     Urocanase]) and not (POR or POR_N or PFOR_II))"
                     /neighbourhood="10000"
                     /product="TPP_AA_metabolism"
                     /protocluster_number="1"
     cand_cluster    1..10734
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(TPP_enzyme_C and not (PFL-like or
                     PFL_6_pcresol or PFL_9_tma or Gly_radical or Gly_430_pcre
                     or Gly_8-9_TMA or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and
                     minimum(2, [ALS_ss_C, AlaDh_PNT_C, Arginase, BKACE,
                     BcrAD_BadFG, Beta_elim_lyase, CPSase_L_D2, Cys_Met_Meta_PP,
                     ELFV_dehydrog, GRDB, Glu_syn_central, Glu_synthase,
                     Gly_reductase, HAAA1, HG2B1, HG2B2, HGD-D, HleuD1, HleuD2,
                     HleuS1, HleuS2, Homoserine_dh, ILVD_EDD, IlvC,
                     Lactoyl-CoA1, Lactoyl-CoA2, Lyase_aromatic, MAAL_C,
                     OKR_DC_1_5_lysine, OKR_DC_1_5_ornithine,
                     OKR_DC_1_7_arginine, OKR_DC_1_C, OTCace, PALP,
                     Proline_reductase, Sacchrp_dh_C, TPL, Thr_dehydrat_C, TnaA,
                     Urocanase]) and not (POR or POR_N or PFOR_II))"
                     /kind="single"
                     /product="TPP_AA_metabolism"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..10734
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="TPP_AA_metabolism"
                     /region_number="1"
                     /rules="(TPP_enzyme_C and not (PFL-like or PFL_6_pcresol or
                     PFL_9_tma or Gly_radical or Gly_430_pcre or Gly_8-9_TMA or
                     PFL_acetate1 or PFL_acetate2 or Gly_radical_scatole or
                     PFL_proline or PFL_toluene) and minimum(2, [ALS_ss_C,
                     AlaDh_PNT_C, Arginase, BKACE, BcrAD_BadFG, Beta_elim_lyase,
                     CPSase_L_D2, Cys_Met_Meta_PP, ELFV_dehydrog, GRDB,
                     Glu_syn_central, Glu_synthase, Gly_reductase, HAAA1, HG2B1,
                     HG2B2, HGD-D, HleuD1, HleuD2, HleuS1, HleuS2,
                     Homoserine_dh, ILVD_EDD, IlvC, Lactoyl-CoA1, Lactoyl-CoA2,
                     Lyase_aromatic, MAAL_C, OKR_DC_1_5_lysine,
                     OKR_DC_1_5_ornithine, OKR_DC_1_7_arginine, OKR_DC_1_C,
                     OTCace, PALP, Proline_reductase, Sacchrp_dh_C, TPL,
                     Thr_dehydrat_C, TnaA, Urocanase]) and not (POR or POR_N or
                     PFOR_II))"
                     /tool="gutsmash"
     CDS             305..1789
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: PALP"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg16_1"
                     /sec_met_domain="PALP (E-value: 1.6e-17, bitscore: 52.8,
                     seeds: 146, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTLVYQSTRDENNKVTASQAILQGLATDGGLFTPLSTPEVTLNFD
                     QLKDASYQEVAKLVLSAFLDDFTEEELDYCITNAYDDKFDTAAIAPVVKLKNHYNLELF
                     HGSTIAFKDMALSILPYLLTTSAKKQGVDNKIVILTATSGDTGKAAMAGFADVPGTEII
                     VFYPKDGVSKIQELQMTTQTGANTHVIAIDGNFDDAQTDVKRMFNDVDLREKLLAHHTQ
                     FSSANSMNVGRLVPQVVYYVYAYAQLVKAGHIQNGDKVNFTVPTGNFGNILAAYYAHQI
                     GVPVGKLICASNENNVLTDFFATGTYDKKRDFKVTTSPSMDILVSSNLERLIFHLLGND
                     ATKTKELMDALVTKGEYTLADADKDILDLFAAGFATEDETAAEIKRVYDEDKYIEDPHT
                     AVASAVYEAYVQKTDDHTPTVIASTASPYKFPRVAVSAVTGKDSGDDFKAVEDLHQLSG
                     VAIPAAVDGLEHAEVRHKTVVAAADMQKAVESYLGV"
     CDS             1850..3136
                     /locus_tag="ctg16_2"
                     /transl_table=11
                     /translation="MTETKKILNIALPAMAENLLQMLMGVVDSYLVAQVGIVAISGVSV
                     ANNIITIYQAIFIALGASSASVIARSLGKGDVKATNRDTWDAIIITLALSLILGLLSIF
                     GGGAILNLLGTEQSVTQAGSLYLALVGGGVVFLALMTTFGNILRAKGRPRISMVVSLLT
                     NVLNAILSSLAIFVGHWGIVGVATATVFSRLVGTVILWQAMKLDVKQLEITKPFNRELL
                     GIALPAAGERLMMRAGDVVIVAIIVTFGTAVVGGNAIGENLTQFNYMPGMGVATATVIL
                     VANSLGRGDKTQMKRIIRESYWISTFLMVLVSGSILLFGQGLSGLFTDNKAAIAASQVV
                     ILYSFLGNPVTSGTLVYTAVWQGLGKAKMPFYATTIGMWIIRIFSGYFLGVSLGMGLAG
                     VWIATVVDNVWRAIFLYVMYRRYLVKRKF"
     CDS             3248..3613
                     /locus_tag="ctg16_3"
                     /transl_table=11
                     /translation="MTVKINTKDGQIELSDDVIATVVGGSATEIFGVVGMASKSAIRDN
                     FQALLGKENYAKGVVVKSTDAGITVDVYTVMSYGVKISEVSKNIQERVKFNLENQLGIK
                     AETVNVYVQNIKVVGEN"
     CDS             3613..5280
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Dak2"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg16_4"
                     /sec_met_domain="Dak2 (E-value: 1.9e-44, bitscore: 140.7,
                     seeds: 138, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="VSKITTSLLQEMVQAAATRLGKQAEYVNSLNVFPVPDGDTGTNMG
                     MTMDNGAKAVADQSASTVGEVGQILSKGLLMGARGNSGVITSQLFRGFGQSIKDKTELD
                     GQDLAHAFQAGVEVAYKAVMKPVEGTILTVSRGAASAAIKKAESTNDAVEVMRAALDGA
                     KAALAKTPEMLPVLKEVGVVDSGGQGLVFIYEGFLSALTGEYIASEDFQATPATMTEMI
                     NAEHHKSVAGHVATEDITFGYCTEIMIGLKQGPTYVKDFDYEEFQNYLSNLGDSLLVVN
                     DDEIVKVHVHTEDPGLVMQEGLKYGALVKVKVDNMRNQHDAQVQKEEAIQAAPSAPKDF
                     ALIAVVAGDGLADIFKSQGVDYVISGGQTMNPSTEDIVKAIEQVNAKNVIILPNNKNIF
                     MAAQSAAEVVDVNAAVVETRTVPQGFTSLLAFDPSQSIEANVEAMTASLSDVTSGSVTL
                     AVRDTTIDGLEIHENDILGMVDGKILVSTPDMDQALLDTFDKMIDEDSEIVMIYVGEEG
                     NQEQAQALAEKLEEAHEGIEVEIFQGDQPVYPYLFSVE"
     CDS             5450..7171
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: ILVD_EDD"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg16_5"
                     /sec_met_domain="ILVD_EDD (E-value: 2.3e-225, bitscore:
                     738.1, seeds: 918, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRSDMIKVGVDKAPARGLLYATGQVKSAKDMQKPFIAICNSYIDI
                     VPGHVHLRELADIAKEAIREAGGIPFEFNTIGVDDGIAMGHIGMRYSLPSRELIADSAE
                     TVINAHWFDGVFYIPNCDKITPGMILAAMRTNVPAVFCSGGPMKGGVDMTGHQATLSSL
                     FEAVGTYQAGDMSKEELDYLEKNACPTCGSCSGMFTANSMNCLMEVLGLALPGNGTILA
                     VSDERRELVRQAATKLMDNIKNNVRPRDIVTKEAIDDAFALDMAMGGSTNTVLHTLAIA
                     REAGIDYDLKDINEIAKKTPYLSKIAPSSVYTMHDVHEAGGVPAIINQLIKKGAIKGDR
                     ITVTGKTLKENVAGAEIKNEEIIHPIEHPISPVGGLSILYGNIAQDGAVIKVGGVDPSV
                     KTFRGKAICCDSQDQALELIDNGTVKKGHVVVIRYEGPQGGPGMPEMLAPTSKIVGRGL
                     GKDVALITDGRFSGATRGIAIGHVSPEAAEGGNIALIEDGDEIVIDLPNRTLDLLVDDV
                     TLEERRKHLKPFKSKISSGWLRRYTAFAKSANVGGTLMSDEEFEERKAERQAQEKN"
     CDS             7305..9005
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: TPP_enzyme_C"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg16_6"
                     /sec_met_domain="TPP_enzyme_C (E-value: 9.1e-49, bitscore:
                     154.3, seeds: 323, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="VKKIELEEARSGADLILDTLLELGISTIFGYPGGAVLPLYDAIYK
                     NDKINHILSRHEQGSLHEAEGYAKSTGKLGVALVTSGPGATNAITGIADAMSDSVPLLV
                     FTGQVATSGIGKDAFQEADIVGITMPITKYNYQIRDTADIPRIIREAVHIATTGRPGPV
                     VIDLPKDVVAKETAFINDPEINLPSYQPTLRPNEMQIKKILKQLGKAKKPVIVAGGGVS
                     YSESAKELVAFAERYQIPVVTSLLGQGTIATSHPLFLGMGGMHGSYAANIAMTDADFMI
                     AIGCRFDDRLTGNPKTFAKNAKVVHIDVDPAEIGKIIAVDLPVVGDAKQALEMLLAEPV
                     VQNNTEKWIEKVTKDKERVRSYDKKERMVQPQAVIERIGELTKGDAVVVTDVGQHQMWT
                     AQYYPYQNERQLVTSGGLGTMGFGVPAAIGAKIANPDKEVILFVGDGGFQMTNQELAIL
                     NIYKVPIKVVMLNNHSLGMVRQWQESFYEGRTSESVFDTLPDFQLMAQAYGIKSYKFDN
                     PETIDQDLEVIKEDVPMFIEVDISRKEHVLPIVPAGKSNHEMLGVKFNA"
     CDS             8998..9474
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: ALS_ss_C"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg16_7"
                     /sec_met_domain="ALS_ss_C (E-value: 2.8e-29, bitscore:
                     90.4, seeds: 685, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRRMLTAKLQNRSGVLNRFTGVLSRRQVNIESISVGASEDPNVSR
                     ITIIIDVNSQNEVEQIIKQLNRQIDVIRIRDITDQPHLEREVILVKVSAPTSKRAEILA
                     IIQPFRASVVDVAPSSITIQMTGDAEKSEALLRVIRPYGIKNIARTGATGFTRD"
     CDS             9549..10571
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: IlvC"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) IlvN"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg16_8"
                     /sec_met_domain="IlvN (E-value: 7.7e-81, bitscore: 258.6,
                     seeds: 43, tool: rule-based-clusters)"
                     /sec_met_domain="IlvC (E-value: 1.4e-63, bitscore: 202.6,
                     seeds: 295, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAVQMEYEKDVKVAALDGKKIAVIGYGSQGHAHAQNLRDSGHDVI
                     IGVRPGKSFDKAKEDGFDTYTVAEATKLADIIMVLAPDEIQKDIYKDEIEPNLSAGKAL
                     GFAHGFNIHFEFIKVPKDVDVFMVAPKGPGHLVRRTYTEGFGVPALYAVYQDATGNAKD
                     IAMDWAKGIGSARVGLLVTTFKEETEEDLFGEQAVLMGGLTHLIEAGFEVLTEAGYAPQ
                     LAYFEVLHEMKLIVDLIYEGGFKKMRQSCSNTAEFGDFVTGPRVIGPEVKENMKAALAD
                     IQSGKFAREFVEDHDAGFPRLKAYRKEAEELEIEKIGAELRKAMPFVGQNDDDAFKIYN
                     "
ORIGIN
        1 ttttggtctt taattccgat taattctgtg gtattcttaa taagtctcat aagttcttcc
       61 taatgatggt ttggttgctt ttcattatag ttcttatggg actttttgtc tgcattcaaa
      121 aagctctata atctctacag tgattttacc cactacagaa attatagagc cattttttca
      181 tgtctttgag aggagaaaat agggtgatat ccgaatgatt ttttcacaag tcacaaaacg
      241 tgtagaaata ttctgacaat tatgttacaa tagagccaca gactatctaa aaagaggatt
      301 taccatgaca cttgtatacc aatcaacacg tgacgaaaat aataaagtaa cagctagtca
      361 ggctattctt caaggtttgg caacagatgg tggcttgttc acaccgttgt caacgcctga
      421 ggttactttg aactttgatc aattgaaaga tgcttcttac caagaagttg ctaaattagt
      481 cttgtcagct ttcttggatg attttactga agaggaattg gattactgta tcacaaatgc
      541 ttatgatgac aagtttgata cagctgccat tgcaccagta gttaaactta agaaccacta
      601 caaccttgaa cttttccatg gttctactat cgctttcaaa gacatggccc tttcaatctt
      661 gccttacttg ctaacaacat cagctaaaaa gcaaggtgtt gataataaga ttgtcatctt
      721 gacagcgaca tcaggtgaca ctggtaaagc tgccatggct ggttttgcag atgttcctgg
      781 aactgaaatc attgtctttt atccaaaaga cggtgtttca aaaatccaag aattgcaaat
      841 gaccactcaa acaggagcta atacgcacgt tattgccatt gatggtaact ttgatgatgc
      901 tcaaacagat gtgaaacgta tgtttaatga tgttgatttg cgtgagaaat tgttggctca
      961 tcatacgcaa ttctcatcag ctaactcaat gaacgttggt cgtttggtac cgcaagtggt
     1021 ttactatgta tatgcctatg cacagttggt taaggcaggt catatccaaa acggagataa
     1081 ggtgaacttc acagtaccaa caggaaactt tggtaatatc ttggcggctt attatgcaca
     1141 tcagattggt gttccagttg gcaaattaat ctgtgcttct aatgaaaata acgtccttac
     1201 agacttcttc gcaacgggta cttatgataa gaaacgtgac ttcaaggtaa caacaagccc
     1261 ttctatggat atcttggtat cttctaactt ggaacgtttg attttccacc ttcttggtaa
     1321 tgatgctact aagactaaag agcttatgga tgcacttgtg actaagggtg agtatacttt
     1381 ggctgatgca gataaagata ttcttgattt gtttgcagca ggttttgcaa ctgaggatga
     1441 aacagctgct gaaatcaagc gtgtctatga tgaagacaag tatatcgaag atcctcatac
     1501 agcagttgcc tcagctgttt acgaagcata tgttcaaaag acagatgacc acacaccaac
     1561 agttatcgct tcaacagcta gcccatacaa attcccacgt gtggcagttt cagctgtcac
     1621 tggtaaagac agtggggatg atttcaaagc agtagaagat ttgcaccaac tttcaggtgt
     1681 agctatccca gcggctgtag atggacttga acatgcagaa gttcgccata aaacagttgt
     1741 tgcggcagct gatatgcaaa aagcagttga aagctatctt ggtgtataag aataaaaaaa
     1801 taggagctga gaaatcagcc ctatttttat caatatagaa aagaatatta tgacagaaac
     1861 aaagaaaatt ctaaacatag ccttgcctgc tatggccgaa aaccttctac aaatgttgat
     1921 gggggttgtc gattcttacc tagtggctca ggtgggtatt gtcgctatat cgggggtttc
     1981 cgtagccaat aatatcatta cgatttacca agctatcttt attgctctag gagcctcaag
     2041 tgccagtgtc attgccagga gtttaggaaa aggtgatgtt aaagcgacta accgagacac
     2101 ttgggatgct attattatta cccttgctct tagtctcatc cttggtctac tttccatttt
     2161 tggtggtggg gccattctta atcttttagg tactgagcaa tctgtgactc aggctggtag
     2221 tctctacctt gctcttgtcg gtggaggagt ggttttccta gccttgatga ccacttttgg
     2281 taacatccta cgggccaagg gacgacctcg tatttccatg gtcgtcagtc ttttgaccaa
     2341 tgttcttaat gctattttat cttctttagc tatctttgtt ggacattggg ggattgttgg
     2401 ggtcgctaca gctacggttt tctctcgtct ggttgggaca gtgatactct ggcaagcgat
     2461 gaaactagat gtgaagcagc ttgaaattac caaacctttt aatagagagt tgttggggat
     2521 tgcactgcca gcagcaggtg aacgactgat gatgcgtgct ggagatgtgg tcatcgtggc
     2581 tattattgtt acctttggta cagccgttgt cggtggtaac gccattggtg aaaacctcac
     2641 ccagtttaac tatatgcctg gtatgggagt cgcaacggct acggttatct tggttgccaa
     2701 tagtctgggt cgaggggata agacgcagat gaagcgtatt atacgagagt cttattggat
     2761 ttccaccttc ttgatggttc tggtttcagg gagtatcttg ctctttggcc aaggattatc
     2821 aggtctcttt acagataata aagcagctat tgcggctagt caggtagtta ttctttattc
     2881 tttccttggg aatcctgtga cttcggggac tttagtttac acagcagttt ggcaaggtct
     2941 gggtaaggct aagatgcctt tctatgcgac aactattggg atgtggatta ttcgaatttt
     3001 ctcaggatac ttccttgggg tgagtctggg aatgggtctt gctggtgtct ggattgcaac
     3061 cgttgttgat aatgtatggc gtgcgatctt cctctacgtg atgtaccgtc gttatctcgt
     3121 aaagagaaag ttttaaggat aaatactgag gagatactct tattcaaagg gtatcttctt
     3181 cttatttttt acaagtaggc tcgaatatgg taaaataagc tgataaaaac tttttgaggt
     3241 agtaattatg actgtaaaaa tcaatacaaa agatggtcaa atcgaattgt cagatgatgt
     3301 catcgcaaca gtagttggcg gttcagcaac agaaattttt ggcgttgtcg gtatggcaag
     3361 taagagtgct atccgagata attttcaagc acttcttgga aaagaaaact acgcaaaagg
     3421 agttgtcgtg aaatctactg atgcaggtat cactgttgat gtctacactg ttatgagtta
     3481 cggtgttaag attagtgagg tttcaaaaaa tattcaagaa cgtgtgaaat ttaatcttga
     3541 gaatcaactc ggtatcaagg ctgaaacagt aaatgtttac gttcaaaata ttaaagtcgt
     3601 aggagaaaac tagtgtctaa aattacaaca agcttgcttc aggagatggt ccaagcggca
     3661 gcaacacgtc taggtaagca agcagaatat gtgaattcac tcaatgtctt cccagtacca
     3721 gatggagata ctggaacaaa catgggaatg actatggata acggagctaa agctgtcgca
     3781 gatcaatcag cttcaacagt tggtgaagtt ggtcagattt tgtctaaagg tcttttgatg
     3841 ggtgcccgtg gtaactcagg tgttatcacc tcacaattgt tccgtggatt tggtcaaagt
     3901 atcaaggaca aaacggaact tgacggccaa gatctagctc atgccttcca agcaggggtt
     3961 gaagttgctt ataaagctgt tatgaaacct gttgaaggaa caatccttac agtatcacgt
     4021 ggtgcagctt cagcagcgat taagaaagct gaatctacaa atgatgctgt tgaggttatg
     4081 cgtgcagctc tcgatggagc taaggctgcc ttggctaaga caccagagat gcttccagtt
     4141 ttgaaagaag ttggtgtggt agactcaggt ggtcaaggtt tggtcttcat ttatgaaggt
     4201 ttcttgtcag ccctcacagg tgagtatatc gcttcagagg acttccaagc gacacctgct
     4261 acgatgacag agatgatcaa tgcagaacat cataagtcag ttgctggtca tgttgcaaca
     4321 gaagacatta cttttggtta ctgtacggaa atcatgattg gtctcaaaca aggtccaact
     4381 tatgtgaagg actttgacta tgaagagttc caaaattact tgagcaacct tggggattct
     4441 ctccttgttg ttaatgacga tgaaattgtc aaagttcacg tccacactga ggatccaggt
     4501 cttgtcatgc aagaaggtct taaatatggg gctcttgtca aagttaaggt tgacaacatg
     4561 cgtaaccaac acgatgcaca agttcaaaaa gaagaagcta tccaagctgc accttctgct
     4621 cctaaagact ttgctcttat tgcagttgtt gctggagatg ggcttgcaga tatcttcaaa
     4681 tcacaaggtg ttgactatgt gatttcaggt ggtcaaacaa tgaacccatc aacagaagat
     4741 attgttaagg ctattgagca ggttaatgct aagaatgtta tcatcttgcc aaacaataaa
     4801 aacatcttta tggcagcaca atcagctgct gaagtagtag atgtcaatgc ggcagttgtt
     4861 gaaacgcgta cagtaccaca aggctttaca agcttgcttg cttttgatcc tagccaaagt
     4921 atcgaagcga atgttgaagc tatgacagct agtctttcag atgtaacaag tggtagcgtg
     4981 accttggcgg tacgtgacac aactattgac ggacttgaga ttcatgaaaa tgatatcctt
     5041 ggtatggttg atggtaagat ccttgtgtct acaccagata tggatcaagc ccttcttgac
     5101 acttttgaca agatgattga cgaagacagt gaaattgtta tgatttatgt cggcgaagaa
     5161 ggtaatcaag aacaagctca agcacttgcg gaaaaattgg aagaggctca cgaaggtatc
     5221 gaagttgaaa tcttccaagg agaccaacca gtttatccat acctctttag tgttgaataa
     5281 tattgaaata atcatttagg aagtcttaga gcttcctttt tgttttgtca gttttgatac
     5341 ggctgggaca tcttttcgaa attacagaaa tattctgaaa attccttgac attactttcc
     5401 aaagtggtaa catatgttgt aagaaatttt atagattgaa ggtaacatca tgagaagtga
     5461 tatgattaaa gttggtgttg ataaggcacc agcacgcgga cttttgtatg cgactgggca
     5521 agttaaatct gccaaggata tgcaaaagcc tttcattgct atttgtaact cttatattga
     5581 tattgttcca gggcatgttc acttgcgtga attagcagat attgccaagg aagctatccg
     5641 cgaggctggc ggtattcctt ttgagtttaa taccattggt gtggatgatg ggattgccat
     5701 ggggcatatt gggatgcgtt acagtcttcc atctcgtgaa ttgattgccg attctgcaga
     5761 aacagttatt aatgcccact ggtttgacgg ggttttctat attcctaact gtgataagat
     5821 tacgccaggg atgattttgg cagccatgcg tactaatgtg ccagcagtat tttgttctgg
     5881 tggccctatg aagggtggcg ttgacatgac tggtcatcaa gcgacgctat caagtttgtt
     5941 tgaagctgta ggtacctatc aggctggaga tatgagcaag gaagagctcg attatttgga
     6001 gaaaaatgct tgtccaactt gtggttcatg ttcaggaatg tttaccgcta actcaatgaa
     6061 ctgtttgatg gaagttttgg gtcttgccct tccaggtaac ggtactatcc tagctgtctc
     6121 agatgaacgt cgtgaattgg ttcgtcaagc agccacaaaa ttgatggata acatcaaaaa
     6181 taatgttcgc ccacgtgata ttgtgaccaa agaagctatc gatgatgcgt ttgctcttga
     6241 tatggctatg ggtggttcaa ccaatactgt tctccatacc cttgctattg cgcgtgaggc
     6301 tggtattgat tatgacctta aggacattaa tgaaattgcc aagaagacac cttatctctc
     6361 taaaattgcc ccttcaagtg tttacaccat gcatgatgtg catgaagctg gtggtgttcc
     6421 agccattatc aatcagttga ttaaaaaggg agccattaag ggtgatcgta ttacagttac
     6481 tggtaaaacc ttgaaagaaa atgtagctgg tgctgaaatc aaaaatgaag aaattatcca
     6541 tccgattgag catcctattt caccagttgg tggtttgtct attctttacg gaaatattgc
     6601 tcaggatgga gctgttatca aggttggtgg tgtagatcca tctgttaaaa ctttccgcgg
     6661 taaagctatt tgttgtgatt cacaagatca agcccttgag ttgattgaca atggaacagt
     6721 taagaaggga catgtcgttg tcattcgata cgaaggtcct cagggtggtc ctggtatgcc
     6781 agaaatgttg gcaccaactt ctaagattgt cggacgcggt cttggtaagg atgtggcact
     6841 gattacggat ggccgtttct caggagctac tcgtggtatt gctattggtc acgtttctcc
     6901 agaagcagca gaaggtggta atatcgccct aatcgaagat ggcgatgaaa tcgtgattga
     6961 tcttccaaac cgtactcttg atctgcttgt cgatgatgta acccttgaag aacgtcgcaa
     7021 acatttgaaa cctttcaaat caaaaatttc aagtggttgg ttgcgtcgct atacagcctt
     7081 tgctaaatca gccaatgtcg gcggaacttt gatgagtgac gaagaattcg aagaacgtaa
     7141 agcagaacgt caagcacaag aaaaaaacta agaacattct ttccgaagag tttgtgatat
     7201 ttttctctga aacccttgca aatttggtta aaaatgttat catagtatac aaggttttga
     7261 atttttagac aattcgaaaa aaacaactac taaaggaggt ccatgtgaag aaaattgaac
     7321 ttgaagaagc acgctctggt gctgatttga ttcttgatac acttcttgaa cttgggattt
     7381 caactatctt tggatatcct ggcggagcgg ttcttccttt gtatgatgct atttacaaaa
     7441 atgacaagat taatcatatc ttatctcgtc atgagcaagg aagtctgcac gaagctgaag
     7501 gttatgccaa atcaactggt aaactcggtg ttgctcttgt aacgagtggt cctggtgcca
     7561 ctaatgctat tacagggatt gcagatgcta tgagtgatag cgtacctctc ctagtcttta
     7621 ctggtcaggt agcaacatca ggtattggta aggatgcctt ccaagaggct gacattgtcg
     7681 gaattaccat gccgattaca aaatacaatt atcagattcg cgatacagct gatattcctc
     7741 gtattattag ggaagcggtt catattgcaa caactggtcg tcctggtcca gttgttatcg
     7801 acctccctaa agatgtcgta gctaaggaaa cagccttcat caacgatcct gaaattaatc
     7861 ttccaagtta ccaaccgacg ctaagaccaa acgaaatgca aatcaagaaa atcttgaagc
     7921 agttggggaa agctaagaaa ccggttattg tagctggagg tggggtgtct tattctgaat
     7981 ctgctaagga gctagttgct tttgcagaac gctaccaaat cccagttgtc acaagtcttc
     8041 taggacaagg gacaattgct actagtcatc cccttttctt gggtatgggt ggtatgcacg
     8101 gttcatatgc ggctaacatt gctatgacgg atgctgactt tatgattgct attggttgtc
     8161 gttttgatga ccgtttgaca ggtaatccta aaacatttgc taagaatgct aaggttgtcc
     8221 atattgatgt agatccagct gagattggta aaattattgc agtggacctt ccagttgttg
     8281 gtgatgctaa gcaagctctt gaaatgctct tagcagaacc agtggttcag aataacactg
     8341 aaaaatggat tgaaaaagtc acaaaagaca aagaacgtgt acgttcttac gataagaaag
     8401 aacgtatggt acagcctcag gcagttatcg agcgtatcgg tgaattgact aagggtgatg
     8461 ccgttgttgt tactgacgtt ggacaacatc aaatgtggac agctcagtat tatccatacc
     8521 aaaatgagcg tcaactggtg acctcaggtg gtcttggaac aatgggattc ggtgtcccag
     8581 cagcaattgg tgctaaaatt gctaatcctg ataaagaagt tatcctcttt gttggtgatg
     8641 gtggtttcca aatgacgaac caagaattgg ctatcttaaa tatttacaag gtgccaatca
     8701 aggttgttat gttgaacaac cactcacttg gtatggtacg tcaatggcaa gagtccttct
     8761 acgaagggcg tacatcagag tctgtctttg ataccctccc agatttccaa ttgatggctc
     8821 aagcttacgg cattaagtcc tacaagtttg ataatccaga gacaattgat caggatttgg
     8881 aagttatcaa ggaagacgta ccaatgttca tcgaggtgga tatctctcgt aaagagcatg
     8941 tcttgccaat cgttccggct ggtaagagta atcatgaaat gttgggggtg aagttcaatg
     9001 cgtagaatgt taacagctaa acttcagaac cgttcgggtg tccttaaccg cttcacaggt
     9061 gttctttcac gacgtcaagt taatattgaa agtatctctg taggggcttc tgaggatcct
     9121 aacgtttcac gtattacgat tattattgat gtgaattctc aaaatgaagt ggaacaaatc
     9181 atcaaacagc ttaatcgtca gattgatgtg atccgtatcc gtgatatcac ggatcagcca
     9241 cacttggaac gtgaagttat cctagttaag gtatcagcac caacctctaa gcgtgctgaa
     9301 atcttggcga ttattcaacc tttccgtgct tcggtggttg atgtggcacc aagctctatc
     9361 actatccaga tgactggtga tgctgaaaag agcgaggcgc ttctacgagt tattcgtcct
     9421 tacggaatca agaatatcgc tcgtacgggt gctactggat ttacccgtga ttaaaaaatc
     9481 caacctaaat ttgttaaccc agccttaaaa aggcaataaa atatttttta gaaaagagac
     9541 atattactat ggcagttcaa atggaatatg aaaaagacgt aaaagtagca gcacttgacg
     9601 gtaaaaaaat cgccgttatc ggttacggtt cacaaggtca tgcgcatgca caaaacttgc
     9661 gtgattcagg tcacgatgtg atcatcggtg ttcgtccagg taaatcattt gataaagcta
     9721 aagaagatgg ttttgatact tacacagtag cagaagcaac taaattggct gatatcatta
     9781 tggttttggc accagatgaa attcaaaaag atatctataa agatgaaatt gagccaaact
     9841 tgagtgcagg caaagctctt ggttttgcac acggatttaa catccacttc gaattcatca
     9901 aggttcctaa agatgttgat gtctttatgg ttgctcctaa aggaccaggt cacttggtac
     9961 gccgtacata tacagaaggc tttggtgttc ctgcacttta cgcagtatac caagatgcta
    10021 caggtaatgc taaagatatc gctatggact gggctaaagg tattggttct gcacgtgttg
    10081 gattacttgt aacaacattt aaagaagaaa ctgaagaaga tttgtttggt gaacaagcgg
    10141 ttcttatggg tgggttgaca caccttattg aagctggttt tgaagtcttg actgaagcag
    10201 gctatgcacc acaattagct tactttgaag tgcttcacga aatgaaattg attgttgact
    10261 tgatctacga aggtggattc aagaaaatgc gtcaatcatg ttcaaatact gcagaatttg
    10321 gtgactttgt aactggtcca cgtgtcatcg gtccagaagt caaagaaaac atgaaagctg
    10381 cccttgctga tatccaatca ggtaaatttg cacgtgaatt cgttgaagac catgatgctg
    10441 gcttcccacg tttgaaagct taccgtaaag aagctgaaga gcttgaaatt gaaaagattg
    10501 gtgctgaatt gcgtaaagca atgccattcg ttggtcaaaa cgacgatgac gcattcaaaa
    10561 tctataacta atgtgatagt ctcaaaaacc agtttagtac tggttttttt gtgttctgaa
    10621 gagagtagtt ggtaatcaat cctactgctc ttttttggtc ttgaatatac aatataagtg
    10681 cacaataaaa actcataaga ttttctagta aaatagaatt gaacgaacta gtta
//
