LOCUS       gnlProkkaBEJHNKKA_22   16002 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|BEJHNKKA_22.
ACCESSION   gnlProkkaBEJHNKKA_22
VERSION     gnlProkkaBEJHNKKA_22
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2025-04-28 09:21:44
            Original ID  :: gnl|Prokka|BEJHNKKA_22
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 71422
            Orig. end    :: 87424
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..16002
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="True"
                     /core_location="[10000:12571]"
                     /cutoff="20000"
                     /detection_rule="(micKC and not PKS_KS)"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-iii"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..12571
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(micKC and not PKS_KS)"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-iii"
                     /protocluster_number="1"
     cand_cluster    1..16002
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(micKC and not PKS_KS)"
                     /kind="single"
                     /product="lanthipeptide-class-iii"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..16002
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="lanthipeptide-class-iii"
                     /region_number="1"
                     /rules="(micKC and not PKS_KS)"
                     /tool="antismash"
     CDS             7..882
                     /gene_functions="regulatory (smcogs) SMCOG1287:AraC family
                     transcriptional regulator (Score: 70; E-value: 3.1e-21)"
                     /gene_kind="regulatory"
                     /locus_tag="ctg22_76"
                     /transl_table=11
                     /translation="MKNFVIDQNLKELTEHRTVELPVACYETRINQNINGYIPLHWHDE
                     IQFVLILKGIALFQINEEKIEVHEGDGLFINSGCLHMAEEKEGSDCTYICLNVSPHFVL
                     SQELYSSYVQPYMFSTNLSYLFLDGNQQWAKNILDAVKKINQLIQQKTSLYEIDITMQL
                     TLMWKNLVVNGFQLEYDQSEMIKSHRMKQMLNWIHLHYAEKITLEDIAKAGQLSRSECC
                     RYFKRMLNKTPLRYVMDYRIQKSLLLLQHPESNVTEVSYQVGFNSTSYFISKFQQTMNM
                     TPLSYKKMNL"
     CDS             1113..1997
                     /gene_functions="transport (smcogs) SMCOG1166:transporter,
                     EamA family (Score: 169.5; E-value: 1.7e-51)"
                     /gene_kind="transport"
                     /locus_tag="ctg22_77"
                     /transl_table=11
                     /translation="MKNTLLGSIYLALAASIWGGMYVVVKVVVAVIPPFELVWIRYVIA
                     ILALLIVGLIRKQSWKIHKRDLLLIVAIGIVGNTISIVTQEYGTMLSSAQMGAIITSST
                     PAFMVIFASLLLKEPLNIKKGTSIILATTGVLFIVGNGHIDTSNQLGGISLLVAALTWA
                     LMSVLIKRVPNSYSPILVTTYSTFVAIVALTPFVKPSTIFTPQLHDPKILGGLLYLGIV
                     STACAFLLWNRGLQLLNASSGGLFFFFQPLVGTLLGWILLGEQIGGTFWIGSFLILSGV
                     LLVIKEKEKEVNS"
     CDS             2638..3099
                     /locus_tag="ctg22_78"
                     /transl_table=11
                     /translation="MFQIGDNIVYPMHGAGIIEAIEEKEFLEEKQQYYVIRMSISNMTV
                     MIPTRKILSSNIRPVTDILALKHIMHIFQHGESDRLLPWKQRYKINTDKIKTGEIQEGA
                     EVVRDLMRMKKEKALNASEKKMLDNAYEFLISELEVIKGITEKQIKSFG"
     CDS             complement(3786..3986)
                     /gene_functions="regulatory (smcogs) SMCOG1255:cold-shock
                     DNA-binding domain protein (Score: 96.8; E-value: 1e-29)"
                     /gene_kind="regulatory"
                     /locus_tag="ctg22_79"
                     /transl_table=11
                     /translation="MEQGTVKWFNAEKGFGFIERENGDDVFVHFSAIQSDGFKSLDEGQ
                     KVSFDVEQGARGAQAANVQKA"
     CDS             4694..5722
                     /locus_tag="ctg22_80"
                     /transl_table=11
                     /translation="MKEQNLRTLRKLVTPYEKSDLHKSICQIINTLVPFFLLWCLAYKS
                     LSISYFLTLAISVVAAGFLVRTFIIFHDCCHYSFFKNRKANRILGTLTGILTLHPFDHW
                     AHDHSVHHATSSNLDKRGTGDIWVLTVEEYKEASTKTKIMYRLYRNPFVMFIIGPIYVF
                     GIANRFNRKGAKRKERMNTFVTNLGIVALAALLCWAIGWQNFLLVQVPIFMISGSLGIW
                     MFYIQHTFEDSYFEEDEHWEYVKAAVEGSSFYKLPKVMQWLTGNIGFHHVHHLSPRVPN
                     YKLEKVHNNTEPLQNVPTITLATSLKSLKFRLWDEEGKKFVSFSHLKKASKSQVSARLT
                     TD"
     CDS             complement(6080..6433)
                     /locus_tag="ctg22_81"
                     /transl_table=11
                     /translation="MKMNSITDTITNAIFSPLKSWAEHSPGNWNILIGSGFVLLVVGLI
                     LTFVFTKKMGKTDERTNQIALKGSLCTLCALIFCDLLFPKEYMWQVFFLFKYSIAFFAS
                     AIYLAVRYKKDFL"
     CDS             complement(6430..6663)
                     /locus_tag="ctg22_82"
                     /transl_table=11
                     /translation="MKKDFGDSISNKVYEYRVLARLSQQELAKKVGVSKQTIFVMEKGN
                     YVPTLLLAFRIAEFFNVDVNEIFTYEKGNDQK"
     CDS             complement(6854..7165)
                     /locus_tag="ctg22_83"
                     /transl_table=11
                     /translation="MEKGVGHYKGSYYPDENGQIVLSGHRDTVFRRTGELKKGDQLKVK
                     LPYGSFSYEIDKTKIVDKTDKSIITLQHNKEELILTTCYPFSYIGNAPKRYIIYGKRI"
     CDS             complement(7481..7855)
                     /locus_tag="ctg22_84"
                     /transl_table=11
                     /translation="MVKRFFLVLLTLIMSIVVMLVAAKNSPGDNVISFEQPRILMISIG
                     IVVFLFIPPLVMSFFGNWVVRIVSGVYQCFIVLTFLGLIPIGFLIPDGFLTIVVSIAGT
                     LISIVSVVVTFIDRNKEVKS"
     CDS             complement(8178..9911)
                     /gene_functions="resistance (resist) ABC_efflux (Score:
                     263.3; E-value: 2.6e-80)"
                     /gene_functions="transport (smcogs) SMCOG1288:ABC
                     transporter related protein (Score: 310.2; E-value:
                     4.7e-94)"
                     /gene_kind="transport"
                     /locus_tag="ctg22_85"
                     /transl_table=11
                     /translation="MRPKNPLFFLLCKIKLPLLLILFAISISSIGSISGLFIPLFTGKV
                     VDKFSENTFDWRFIVIFLCMFLINAILSGIGLYLLSKIGEKMIMAIRFMLWEHIIKLKT
                     SFFDNNESGSIMSRITDDTNVINAFVSQKLPNIIPSIITILGSVIILLRMDWQMTLITL
                     IIVPIFLAIIIPLGGMVRKISKKAQSEVASFSGLLGRVLTEIRLVKISNTENQELKNAY
                     NNLFEIYKLGLKESKIISIIQPLTSLILLLTIGIILGFGGIRVSTGVISAGTLVAMIFY
                     VIQLSGPLTNFSTLLTDYQRAIGASQRLSEILLEHKEELESNKNALDIDFSNQNLKFSE
                     VSFKYDDKPILNEITFDIPSRKVTAFVGPSGSGKSTIFNLIARLYELPPSNGSISLEGI
                     PINEFNLSDWRNKIGYVMQTNAMINGTVKDNITYGIKREISEDEIIKYSKLSNCHEFVM
                     LLDKGYSTIIGEKGVKLSGGQRQRIDIARNFIKDPDILLLDEATASLDSESERKIQNSL
                     EELMKNRTTVIIAHRLATIKKADQIIFLDQGVITGKGTHDQLMLTHEKYRRFVSAQKLA
                     N"
     CDS             complement(10001..12571)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-iii: micKC"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Pkinase"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) LANC_like"
                     /gene_functions="regulatory (smcogs)
                     SMCOG1030:serine/threonine protein kinase (Score: 70.9;
                     E-value: 2.1e-21)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg22_86"
                     /sec_met_domain="micKC (E-value: 2.3e-147, bitscore: 484.8,
                     seeds: 18, tool: rule-based-clusters)"
                     /sec_met_domain="Pkinase (E-value: 4.4e-14, bitscore: 45.0,
                     seeds: 54, tool: rule-based-clusters)"
                     /sec_met_domain="LANC_like (E-value: 2.4e-19, bitscore:
                     61.8, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDLRYLNYLSSTNNSFYTKPDIPNRESALYISNIPNNYETIKENH
                     WIHIMNKDYELPMQGWKIHISTTIDSAEKTLEIVSNILFAYKVSFKYVKSLWELSIKNS
                     KYSDRSSAGKFITIFPSNEEVFLNLLKILSRQLDTLPKGPYILTDKRWYDSNVYFRYGA
                     FIGMYFYEDNKKVYAIQSPSGDLVEDSRSPHYSIPEFITEPAPIREMDNKLENELAEPT
                     PLDDIEVIHAIHYSNGGGVYLALDKLDKKVILKEGRPNIGLDSLGIDAFTRIKNEAIIL
                     EKLEGTHYPVKIYDFFKAWEHHFIIEEYIEGTSLRTWLATKYPFYTNEPNKEYQYLKSA
                     LNILDQLIDALTEIHNHGIGIGDLQPSNIIITPEENIRLIDFETASFINDSVPSGLKTF
                     GFTGGPNLTRKQADWFALLRISRYLFLPIGPVQDISSKILEIHDRYIENYFGSEAIKII
                     NKIQNICSRVQANPAKDLLNYEYKYKHIKEMTLNEMKISLQNNIIKNMFVDERVISGDI
                     RQYELNNGLFNILTGGFGAVLAFNRTNIQNEKLNEWVGNQSLDDLLKMENGLLTGKAGI
                     ATSLWESGYFDKAKHLFDSINHFKNNSDITLSSGLSGIGLAFLGLSYEKDSIKYLNKSI
                     EIANRLEELLEKDVSIVPYDMDIIPRGLINGWSGVSLFYSCLYKRTKNPKWLILSKRSI
                     EKDLITGKFDDYGAYQLEDISRVVPYLDGGSAGVGFALIELSLLLKDDLWREELEGIYK
                     IVKSKCFYNCGLFRGTAGIIAASNAIDKYYNRGINADNLKTLDLHLFKGKVEIYTPGDF
                     GYRLSNDIFSGSLGLLLVIQGIINNTNYMWLPVMNIKKVFESNS"
     CDS             complement(12597..12773)
                     /gene_functions="biosynthetic-additional (lanthipeptides)
                     predicted lanthipeptide"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg22_87"
                     /transl_table=11
                     /translation="MSRGKQISNILKLQSLESGSAYNAGATGTVEGQSLSFYSIAFCAT
                     PLPVSAVSAAFCN"
     CDS_motif       complement(12693..12773)
                     /prepeptide="leader"
                     /note="peptide class: {self.peptide_class}"
                     /note="predicted sequence: MSRGKQISNILKLQSLESGSAYNAGAT"
                     /locus_tag="ctg22_87_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       complement(12597..12692)
                     /prepeptide="core"
                     /locus_tag="ctg22_87_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class III"
                     /score="0.10"
                     /molecular_weight="3012.4"
                     /monoisotopic_mass="3010.5"
                     /core_sequence="GTVEGQSLSFYSIAFCATPLPVSAVSAAFCN"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MSRGKQISNILKLQSLESGSAYNAGAT"
                     /leader_location="[12692:12773](-)"
                     /alternative_weights="3030.4"
                     /alternative_weights="3048.4"
                     /alternative_weights="3066.4"
                     /alternative_weights="3084.5"
                     /alternative_weights="3102.5"
     CDS             complement(12890..13018)
                     /locus_tag="ctg22_88"
                     /transl_table=11
                     /translation="MKKLLSLQHKALDKEVTLLKGRSSVSLGCDKISTVSLYFCGN"
     CDS             complement(13056..13184)
                     /locus_tag="ctg22_89"
                     /transl_table=11
                     /translation="MKKLLSLQHKALDKEVTLLKGKSSVSLGCDKISTVSLYFCGN"
     CDS             complement(13221..13349)
                     /locus_tag="ctg22_90"
                     /transl_table=11
                     /translation="MKKLLSLQHKALDKEVTLLKGRSSVSLGCDKISTVSLYFCGN"
     CDS             complement(13386..13514)
                     /locus_tag="ctg22_91"
                     /transl_table=11
                     /translation="MKKLLSLQHKALDKEVTLLKGKSSVSLGCDKISTVSLYFCAN"
     CDS             complement(13552..13680)
                     /locus_tag="ctg22_92"
                     /transl_table=11
                     /translation="MKKLLSLQHKALDKEVTLLKGRSSVSLGCDKISTVSLYFCGN"
     CDS             complement(13643..16000)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Pkinase"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) LANC_like"
                     /gene_functions="regulatory (smcogs)
                     SMCOG1030:serine/threonine protein kinase (Score: 64.5;
                     E-value: 1.9e-19)"
                     /gene_kind="regulatory"
                     /locus_tag="ctg22_93"
                     /sec_met_domain="Pkinase (E-value: 3.7e-18, bitscore: 58.3,
                     seeds: 54, tool: rule-based-clusters)"
                     /sec_met_domain="LANC_like (E-value: 2.6e-24, bitscore:
                     78.2, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSGKFITIYPYDNKTFLTLLSDLDNLTKALKKGPYILNDKRWKYS
                     NVFFRYGAFVSMYVNKDGQNVPAIQRPDGTLIPDVRAPYYEVPDFVEEPVEIQIMTKKV
                     DAELDKEDTSKFDSYNVISALHFSNGGGVYKVEKNGKTFVMKEGRLGSGLDRLKLDGFK
                     RIYKEAETIKQLSEKPYIVDFYDYFEIWENNYLIEEHVSGISLMEYVSQNFPFSYKEDK
                     DIYMERMMHVIDQLIDALKDLHRSKIALGDLQPNNVLVLEDYSIKLIDLETAVTPESKY
                     TPALMTPGYVTDQAETFEQADWYALLRICRFLFLPIENLSDLSIDIEINQDKWIGENFG
                     DEVLNKIQEIQEKTLPTIKKLSKAATLTIPPMKINYKNVNEITEGLRAGIMSHLKPKSE
                     SLISGDIRQFIEKMGSLSIANGGFGGIMALDRTGTLSDSVYQWVDHVLETILNLDTETY
                     KNFPLGLFNGISGILSVLYDIGYKEEAIKLLETMPFPDTEDSDLTLFSGLSGIGLNYLA
                     FYSITQKKDFLDRSIKIGNRIIDAYKEDCSITVRDPYAMPYGLLNGWSGISLYILMLGK
                     ATNDNDLIKLASEIFNKEISKNIEIDSKLELAQIKEYSLGYKRLIPYLGEGAAGIALIM
                     LEFNKNLPDFMTESNTELFKKLTNVTDLYSTFASGIFRGVGGMIILANAMKCAGVNTGS
                     LEYTIKALGNYLLYKKHEGILSPGEYGYRLSLDLQTGNSGLLLALSDIDSDKWSSWLPL
                     PKNNNLNLFEIDKFIKGGETNEKAIITSAQST"
ORIGIN
        1 gtcagaatga agaattttgt gatcgatcaa aatttaaaag aattaacaga gcatcgaacg
       61 gtagaattac cagttgcctg ttacgagaca aggatcaatc aaaatataaa tggctatatt
      121 ccgcttcatt ggcatgatga aatccaattt gttttgatac taaaagggat agctcttttt
      181 caaataaatg aagaaaaaat agaggttcac gaaggggatg gattatttat caatagtggc
      241 tgcctgcaca tggccgaaga aaaggaaggc tcggattgta cgtatatttg cttgaatgtg
      301 tcaccccatt tcgttttatc tcaggaactg tattcaagct atgttcagcc ctatatgttt
      361 tcaaccaatt tgtcctattt atttttggat ggaaatcaac agtgggcaaa aaatattcta
      421 gatgctgtta aaaaaataaa tcaattgatt caacaaaaga catcgctgta tgagattgac
      481 attacgatgc aattaacgtt aatgtggaaa aacctggtcg ttaatggttt tcaattagag
      541 tacgatcaat ctgaaatgat aaaaagtcat cgaatgaaac aaatgttaaa ctggatccat
      601 ctccattatg ctgaaaaaat cacattagag gacattgcaa aagctggcca actgagccgt
      661 tctgagtgct gccgttattt taaacgaatg ctgaataaga cgccattacg ttatgtaatg
      721 gattatagaa ttcaaaaaag cttattatta ctgcaacacc ctgaatccaa tgtgacagaa
      781 gtgtcttatc aagttggatt taacagtacc agttatttca taagtaaatt ccaacaaacg
      841 atgaatatga cgccattatc atacaaaaaa atgaatttat aaagtttatt ctattattaa
      901 atggagtccc cctaaggtgt ttacggcttt aaaaccaaca ttgtataatg atagtcattc
      961 ttaaaaatcg aggtgatcat aacatgtttt tagctccact atttgaaaat gatgttccag
     1021 tagcacttct ctgcccttaa tggagtaaag tgactacttc tctccgttag ggcatttatt
     1081 gacctaattt taaatacgga gggaacaaaa aaatgaaaaa taccctgtta ggttctatat
     1141 atttagcttt agccgctagt atctggggtg gcatgtacgt tgtggttaag gttgttgtcg
     1201 cagtaattcc gccttttgaa ttggtttgga tcaggtacgt catcgctatc cttgcgcttc
     1261 ttattgttgg tttaataagg aaacaatctt ggaaaattca taagcgcgat cttttattaa
     1321 ttgtggccat tggaattgtt ggcaacacca tttcaattgt tacacaagaa tatggaacga
     1381 tgttgtcttc agcacaaatg ggagcaatta ttacgtcctc cacaccagcg ttcatggtta
     1441 tttttgctag tctattactt aaagaaccat tgaatataaa aaaaggaact tcaataattt
     1501 tagcaaccac aggcgtatta tttatagttg gaaacggaca tattgatacc tctaatcagc
     1561 ttggcggtat ttctctgctt gttgcagcac ttacatgggc actgatgtca gtgcttatca
     1621 aacgcgtgcc aaacagctat tcgcctatac ttgttaccac gtattcaact tttgtggcca
     1681 ttgtggcact aactcctttt gtaaaaccta gcacgatttt cacgccacaa ctgcatgacc
     1741 ctaaaattct aggtggtctt ttgtatttgg gaattgtttc aaccgcttgt gcttttttat
     1801 tgtggaaccg cggcttacaa ttattaaatg cttcaagtgg gggcctcttt ttcttttttc
     1861 agcctctggt tggaacctta ctcggatgga ttctgctggg agaacaaata ggcgggacat
     1921 tttggatagg ttcgttttta attcttagcg gtgttttatt agtcattaaa gagaaagaaa
     1981 aagaagtgaa ttcataacaa aaagaaaagc aaactatttt atatagtttg ctttcaatta
     2041 actttgttct ttccccttta cttctttatg ttctggtctt catttataat ccctcctttc
     2101 tttatttttc ttctcacctc aataccattt gaaggttgtc aatttccctg ataataatgc
     2161 caatttggtg gcaaaatgtt cattatcaac aaaccttttt ctgttcgcaa gataagtgaa
     2221 aatgcatcat taagtaagtg ggccgttatc catatcaaat cggtaaagaa attagaactt
     2281 aatcatgtgc tttaaatatt tttagctgac atttcacgaa tatcgttctt tcttatctac
     2341 tcaaatcatt tctgtaatgt cattgagcca agtcatgaat tcctaaagga aattgaataa
     2401 cccattttca atgaaaaact gatctatgtt aattagtcga agttttagga tatacacgga
     2461 tcaattgacc ttttccttga ttggaaatcc gacacgttcc ctattgtttt tgcttgatct
     2521 gtttttttaa aaaaattatt gacatcaaaa attcgatcat gttattatta aaagtttgat
     2581 attccacctc catatatggt aatcttaaga aggttaccat atatggaggt ggatgatatg
     2641 tttcaaattg gcgataacat tgtttatcca atgcacggag caggtataat tgaagccata
     2701 gaagaaaaag aattcttaga ggaaaaacaa cagtattatg tcataagaat gtcaatcagt
     2761 aatatgacag ttatgattcc aacgcgtaaa atattgagtt cgaatatacg accagttacc
     2821 gatatacttg cattaaaaca cattatgcac atttttcagc atggagaatc agataggtta
     2881 ctgccatgga agcaaaggta taaaataaac acggacaaaa taaaaacggg tgaaatacaa
     2941 gaaggcgctg aagttgtacg tgatttaatg cgtatgaaga aagaaaaagc acttaatgca
     3001 agcgaaaaaa aaatgctgga taatgcatat gaatttttga ttagtgaact ggaagtaatt
     3061 aaaggaatca ctgaaaagca aataaaaagt ttcggttaga tagtgtattg atcccaaaaa
     3121 atatttcgga atattatgat gaaaagcaaa tcttctctaa cttatgttta gaacattaac
     3181 gacctctttt gttattccta cattctaatc catttttatt atttacattt cttctgcgaa
     3241 gattgaagtt ttaccaaaaa actcaataaa atagtcactt gttattagta tcctgattca
     3301 cactggcacg gacaaggagc cgtaaggatg gaagagaggt agggctttca ttgttttagg
     3361 tatctctaag tgattatttc cagaagaaaa aaacaatcga tctcctcatt atttttaaga
     3421 atttcttata tccactgcca cattgaataa taattgttta tcttcttctc ataaaagaga
     3481 tatgcgagtt gataacatcc agatgaaacc atttttataa ttcatctaat cttacttaaa
     3541 gtaacgaaca ggttagtgaa aaaaagagct atatttgaac aaaaaattaa ataatttata
     3601 tacattccgc atattgtcaa tccagtatgt tatactgtaa acaaaccttt gaagttttaa
     3661 atctttttct attaccttgt agcatctccc tactcgaacg ttgagtaggg ttttttattg
     3721 agtatgatat agacataaaa aaacaggccc tatataaaga gcctgtttgt ataaacgatt
     3781 gaagattaag ctttttgaac gttagcagct tgagctccac gagcaccttg ctcaacgtca
     3841 aacgatactt tttgaccttc gtctaaagat ttgaatccgt cactttggat tgcagaaaag
     3901 tgtacgaata catcgtctcc attttcgcgt tcgataaagc caaaaccttt ttctgcatta
     3961 aaccatttaa ctgtaccttg ttccattttt gttgcctcct agtgtgtaac cacacagtat
     4021 atactatcct tgcccaaagt atcatcaaga cgaaaagtca atcttcatac tatcctttac
     4081 accgaacaaa aataattctt ctttattata tcaggaatcg gaaataactg caaattatat
     4141 ttacgattta ttcatggcat tatttgttaa acatgtgtat accagcgcag aataagaggc
     4201 ctattaaaaa ctatggtttg aaaacaccgt gaaaaatgaa tcacgagttg tcttcaaacc
     4261 tttttctttg cttaatagta cttagctcag ctgtttcttg ttcaagagca agataatctt
     4321 ttaaaagcag ggctgttcac ttgtaaaact ttgtttctgc agatgtttcc aaacagtcac
     4381 tcatggatat acccattact tcattccttt tttcctcaaa caatcaatgt tcacggtcaa
     4441 ataaatcgat ccccatgggg gagcattgag agagtttgac ccaataaagt gctgggtata
     4501 atcttcatac gccttttgta tcccggctga ctctgctaat aataaactgg aaatcagttt
     4561 attatttcca ataattttac agatgaatgg gaagaatact tatcatatat gaggtgtatc
     4621 acgttgggcc ttctaaggct ataaaacgtt ttttacactt agaagatcac cagggaaggg
     4681 gaaacttttg aatatgaaag aacaaaacct aaggactttg agaaaactgg ttacacctta
     4741 tgaaaagtcc gatttacaca aaagcatttg tcaaatcatt aacacattgg tgccattttt
     4801 cctattatgg tgtttggcat ataagagctt gtcgatttct tatttcctta cattagcgat
     4861 ttctgttgtt gcggcaggtt ttttagtgag aaccttcatc atctttcatg attgctgcca
     4921 ctattccttt tttaaaaaca gaaaggcgaa tcgaatcctt ggaacattaa caggaattct
     4981 gactctgcat ccttttgatc attgggcaca cgaccattct gtccatcatg cgacaagcag
     5041 caatctggac aaacgcggta caggcgatat ttgggtactg acggttgagg aatataagga
     5101 agcctcaact aagacaaaaa taatgtaccg attgtacaga aatccgtttg ttatgtttat
     5161 tattgggccg atttacgttt tcgggattgc caatcgtttt aatcgaaaag gggcaaaacg
     5221 caaagaacgg atgaatacgt ttgtaacgaa cctggggatc gtcgctttgg cagcactttt
     5281 atgttgggct attggctggc aaaacttcct gctggttcag gtgccgattt ttatgatatc
     5341 gggctctctc ggaatttgga tgttttatat tcagcatacg tttgaggatt cttattttga
     5401 agaagatgag cattgggaat atgtaaaagc agcagttgaa ggaagctctt tttataagct
     5461 tccaaaagtc atgcagtggc taacaggcaa tatcggtttt catcatgttc atcatttaag
     5521 cccgagagtc ccaaactata agcttgaaaa agtgcataac aacactgaac cattgcaaaa
     5581 cgttccgacc attacactgg caacaagcct taagtcgtta aagttccgcc tatgggatga
     5641 agaaggcaaa aaatttgtta gttttagcca cttaaaaaaa gcttctaaaa gccaagtatc
     5701 ggcgcggcta acaacggatt aaaataaact caccataatc gcagaataaa agtgcagact
     5761 cgcgcaacga tgttgtgcag aggtcagcac ttttttagtg gactccacaa tgcggtacat
     5821 ttgttgccgt attttccgca aaagaataac gccaaagatg gttaaaccct tggtattatt
     5881 gggggtgcgg ccgagagaac ttgaaccttt acgggttatt caccccactg ggccctcaac
     5941 atggtaaatt catatcactg gttatgaaag cttattttca ttacattttc taacttcatt
     6001 ttacttcatt tctaacggtt tatatgaatt gtggttaata attggtgagc agagacacta
     6061 tctttctcgg taattgaatt tacaaaaaat cttttttata tcgaacggct agatagattg
     6121 ctgaagcgaa gaatgcaata gaatacttaa ataagaagaa aacttgccac atatattctt
     6181 ttgggaaaag caagtcgcaa aaaattagtg cacataacgt acagaggcta ccttttaaag
     6241 cgatttggtt tgttctttcg tcagtcttac ccattttttt agtaaatacg aatgtcagaa
     6301 tcaatccgac tacaagcaat acaaacccac tgccaataag aatattccaa tttcccggag
     6361 aatgttcagc ccaggacttt aaaggagaaa aaattgcgtt agtgatcgta tctgtgatcg
     6421 aattcatttt catttttgat catttccttt ctcataagta aaaatctcgt ttacatccac
     6481 attaaaaaat tcggcaattc gaaaagctaa cagcagagtc ggaacataat ttcctttctc
     6541 cattacaaag atggtttgtt tggaaacccc gactttcttt gctaattctt gctgagacaa
     6601 tctggcaagt acacgatatt cataaacctt atttgagatc gaatcaccaa aatctttctt
     6661 catgaccatc acctcttgaa ccaaattata aactcacctt ataaaaaaag taaagtaaac
     6721 ttatacaaaa atataaaata cttttatgtt tactaagatt actttgattt aatcatgaac
     6781 cagaatgcag aaagaacctg acgaaaaagg ctgacgaaaa ttcgtcagcc taatctttga
     6841 tattctggat ttctcaaatc cgttttccat aaataatata ccgctttggt gcattaccga
     6901 tatatgaaaa tgggtaacaa gtagtaagga taagctcctc tttgttatgc tgcagcgtaa
     6961 taatagactt atcggttttg tccacaattt ttgttttgtc tatctcatat gaaaaacttc
     7021 catatggcag cttaaccttt aattgatcac ctttttttag ttctcctgtt cggcggaaga
     7081 cggtatcccg atggcctgat agaacaattt gtccgttttc atctggataa tagcttcctt
     7141 tgtaatggcc gactcctttt tccaaatcat ccgcatccgt tccttctaca gtccgaagct
     7201 ctgcgtctat ttttggaatc tcaaagacac cgagaaatta tggacaagaa attgcagccc
     7261 gttgagagga tttattttat tgtaaatgaa caatttggga gctgtagatt taggaactgt
     7321 taagatacgc cctgtaactc tctttccgag tatctacact aaaagcaacc ataagtcatc
     7381 aagggcgtta gtcattcgca acatataaac ctataaaaaa agaaagctcc tttccttgaa
     7441 attaaggata aagccttcta accttatttt attatttcag ctaagattta acttctttat
     7501 tcctatcaat aaaggttact acaacgctaa ctatgctgat taaagttcct gcaatagaaa
     7561 caacaatggt caaaaagcca tcgggaataa gaaatcctat tggaatgagc cccagaaagg
     7621 ttagaacgat aaaacattgg tatacaccag atacgattct tacaacccag ttaccaaaaa
     7681 aggacatgac taacggggga atgaataaaa ataccactat cccaattgat atcattaata
     7741 ttcgaggctg ttcaaatgaa atgacattat ctccaggaga atttttagca gccactagca
     7801 taacaactat agacataatt agtgtgagta aaaccagaaa aaatcttttt accatcgtta
     7861 taactccttt ttataattac tttaaaaccg ggttatccgt ctttttctat agccatttta
     7921 tgttctcaat caaagtatat gcagtcaaat tacagctaaa gtaatattta ttactactta
     7981 tcaaaacata acatccacag actatgccga ataattagct gcttttcagt ttaactaatg
     8041 caaaaagtat tcctcatctt acattgttaa gattacacta aatttgtaag gtatcttaat
     8101 tcatttaaca taaatgattt agatgatgat attaaattta ctaataaata gattaaaggg
     8161 gcgagctcgt aatttagtta gttagccaat ttttgggctg acacaaatcg cctgtacttt
     8221 tcatgagtaa gcattaattg gtcatgagtt cctttaccag taatcactcc ttgatctaag
     8281 aaaatgattt gatctgcttt tttaattgtt gctaatctgt gagctattat tactgtagtt
     8341 ctatttttca ttaattcttc tagtgaattc tgtatttttc tctcactctc actgtccaaa
     8401 cttgctgttg cctcatccaa taatagaata tcaggatctt taataaagtt tcttgcaata
     8461 tcaattcgtt gacgctgacc tcctgacaac ttcactcctt tttcgccaat tattgtgcta
     8521 taacctttat ctaacaacat aacaaattca tggcaattag acaatttaga atacttaata
     8581 atttcatctt cactaatttc tcttttgatt ccataagtaa tattatcttt tacggtgcca
     8641 tttatcattg cgttggtttg cattacatat ccaattttat tccgccaatc tgataagtta
     8701 aattcgttaa tcggtattcc ttcgagtgat atgctcccat tacttggggg taattcatac
     8761 aaacgtgcaa ttaaattgaa aatagtactt ttaccagaac cagacggtcc tacaaaagca
     8821 gtaacctttc tacttgggat atcaaaagtt atttcattca aaatcggttt atcatcatat
     8881 ttgaaactta cttctgaaaa tttcaaattt tgattgctga aatcaatatc taaagcattc
     8941 ttattggact ctagctcttc tttgtgctca agtagaattt cacttaatct ttggctagct
     9001 cctatcgcac gctgatagtc tgtaagtaac gttgaaaaat tagtcaaagg gcctgataat
     9061 tgtatgacat agaaaatcat agctactagg gtgccagcag atattacacc cgttgagact
     9121 cttataccgc caaatcccag aataattcct atagtcagta aaaggatgag gctagttaaa
     9181 ggttgtataa ttgaaatgat cttagactct tttaacccta atttatatat ttcaaaaagg
     9241 ttgttataag catttttcaa ttcttgattt tctgtattag atatctttac aagacgtatt
     9301 tctgttaaga cacgccctaa taaaccacta aagcttgcga cttcggattg tgcttttttt
     9361 gagattttcc ttaccattcc gcctaaaggg ataattattg ctaaaaatat aggcactata
     9421 ataagagtta taagagtcat ttgccaatcc attcttaata aaatgataac agagcctaaa
     9481 atagtgatta tagaaggtat tatattgggt aatttttgag atacaaaagc gttgataaca
     9541 ttggtgtcgt ctgtgatacg actcattatt gaaccactct cattattatc aaagaaagag
     9601 gtttttaatt tgattatatg ttcccagagc ataaaacgaa ttgccataat cattttttca
     9661 ccaattttac tgagcaaata taacccaata ccactcaaga tcgcgttaat taaaaacatg
     9721 cataaaaaaa ttactataaa tctccaatca aaggtgttct cagaaaattt atcaacaacc
     9781 ttacctgtaa atagaggtat aaacaaacca ctaatgctgc ctatagatga aatagaaata
     9841 gcaaacaaaa ttaataataa tggaagtttt attttacata ataaaaagaa taaggggttt
     9901 ttaggtctca taataatctc cttttttact tcggatatcc atattcaaaa aaatattaga
     9961 aaagtttcta cctacactct taattgaggg agataaataa ttaagagtta gactcaaata
    10021 cttttttgat gttcatcaca gggagccaca tataattagt attgtttata ataccttgta
    10081 ttacgagcaa caatcctaat gaaccggaaa atatatcatt tgataaacga tacccaaagt
    10141 ctccaggagt atatatttcg acctttcctt taaagaggtg tagatctaaa gttttcaaat
    10201 tatcagcatt tataccccgg ttataatatt tatcaattgc attactagca gcgattatcc
    10261 cagcagtacc tcgaaataac ccacaattgt aaaaacactt tgattttacg attttgtaaa
    10321 tcccttctaa ttcctctctc cataaatcgt cctttaaaag taaactcaat tcaattaatg
    10381 cgaacccaac accagcactt ccaccatcta aataaggaac tactcttgat atatcttcta
    10441 attgataagc tccgtaatca tcaaatttac cagtgatcaa gtctttttca atagatcttt
    10501 tcgataaaat aagccattta ggatttttag ttcttttata taaacaagaa taaaagagtg
    10561 aaacacctga ccacccattg ataagaccac gaggtattat atccatatca taaggaacga
    10621 ttgaaacgtc tttttctaat aattcctcta gccggtttgc aatttctata gatttgttaa
    10681 gatatttgat agagtctttt tcatatgaaa ggcctaaaaa agctaaaccg attccagata
    10741 gtccagatga taatgttata tcactgttat ttttaaaatg attaatgcta tcaaaaagat
    10801 gttttgcttt gtcaaaataa cctgattccc ataaactagt ggctattcca gccttgccag
    10861 tcaaaagtcc attttccatc ttcaataaat cgtctaaaga ttgattacct acccattcgt
    10921 ttaatttttc attttgaata tttgttctat taaaggctaa tacagctcca aaaccgccag
    10981 ttaagatatt aaataatcca ttgtttaatt catactgtct aatatctcct gagattaccc
    11041 tttcatcaac aaacatattt tttattatat tattttgaag tgatatcttc atttcattta
    11101 gtgtcatttc tttaatatgt ttatatttat attcataatt cagtaaatct ttagctggat
    11161 ttgcctgaac tcgtgaacat atattttgta ttttattaat tatttttata gcttcggagc
    11221 caaaataatt ttcaatatat ctatcatgta tctctaaaat ttttgaagaa atatcttgaa
    11281 ctggaccaat aggcaaaaat aaatatctcg atattcttag taatgcaaac caatccgctt
    11341 gttttctagt caaattaggc ccgccagtaa aaccaaatgt ttttaaacct gatggtacac
    11401 tatcattaat aaaactagca gtttcaaagt ctatcaatcg tatattttct tcaggtgtaa
    11461 taataatatt tgagggctgt aaatctccta tccctattcc gtgattatga atttcagtta
    11521 gagcatctat taattgatcc aaaatattta atgctgattt tagatattga tattccttat
    11581 ttggttcatt cgtataaaaa ggatattttg ttgcaagcca agttctaagt gatgtgcctt
    11641 caatatattc ttctataata aaatgatgtt cccaagcctt aaaaaaatca tatattttta
    11701 cgggatagtg cgtcccttca agtttttcca aaattatcgc ttcatttttt attcttgtaa
    11761 aggcatcaat tccaagactg tctaatccga tatttggtct tccttcctta aggataactt
    11821 ttttgtctag tttatctagg gctaagtaga ctccccctcc attactataa tgaattgcat
    11881 ggataacctc tatatcatct aatggagtag gttcagctaa ctcgttttct aatttattat
    11941 ccatctctct tattggagca ggttcagtga taaattcggg tatagaataa tgaggacttc
    12001 ttgagtcttc aactaagtca ccagaaggac tttgaatagc atataccttt ttattatctt
    12061 cataaaaata catgccaata aatgcaccat atctaaagta aacattactg tcgtaccatc
    12121 ttttgtctgt taaaatataa ggacctttag gaagagtgtc tagctgcctg cttaatattt
    12181 tcaacaaatt tagaaatact tcttcatttg acgggaaaat cgtaataaac ttacctgcag
    12241 aagatctgtc gctatacttt gaatttttaa tacttagttc ccataaactt ttaacatatt
    12301 taaaagagac tttataagcg aacaatatat ttgatacaat ttctaatgtt ttttctgcag
    12361 aatctattgt agtacttata tgaattttcc aaccttgcat tggaagttca taatctttat
    12421 tcatgatatg aatccaatga ttttctttta tagtttcata gttattaggt atattagaaa
    12481 tatacaaagc cgactcccta ttagggatat ccggctttgt gtaaaaagaa ttgtttgtcg
    12541 aactaagata atttaaatat cgcaaatcca tatttacaac cctttcaatt gattagttag
    12601 ttgcaaaaag ctgcactcac tgcgctgaca ggaagagggg tagcacaaaa agctatacta
    12661 taaaaagata gtgattggcc ttctacggta cctgtcgccc ctgcattata cgctgaacca
    12721 ctctccaagc tctgcaattt caggatatta ctgatttgct ttcctcttga catttcatcc
    12781 aactcctttt atatttttta gatagtttat tgtatttact ttttgggtaa tacaaagaaa
    12841 agagaggatg atcccctctc ttttctttaa gtagggttgt ccaaaatcat tagttaccac
    12901 agaaatacaa actaactgta ctgatcttat cgcagcctaa gcttactgat gatctgcctt
    12961 ttaatagagt aacctcttta tcaagtgctt tatgctgaag tgataataat tttttcattt
    13021 gttttacctc ctctttagtc taaacagtag taatcttagt taccacagaa atacaaacta
    13081 actgtactga tcttatcgca gcctaagctt actgatgatt tgccttttaa tagagtaact
    13141 tctttatcaa gtgctttgtg ctgaagtgat aatagctttt tcatttattt cacctccttt
    13201 agtctaaaca gtaagtaatc ttagttacca cagaaataca aacttactgt actgatctta
    13261 tcgcagccta agcttactga tgatctgcct tttaatagag taacctcttt atcaagtgct
    13321 ttatgctgaa gtgataatag ctttttcatt tatttcacct cctttagtct aaacagtgag
    13381 taatcttagt tagcacagaa atacaaactt actgtactga tcttatcgca gcctaagctt
    13441 actgatgact tgccttttaa tagagtaacc tctttatcaa gtgctttgtg ctgaagtgat
    13501 aatagctttt tcatttattt cacctccttt agtataaaca gagggtaacc tttagttacc
    13561 gcagaaatac aaacttactg tactgatctt atcgcagcct aagcttactg atgatctgcc
    13621 ttttaataga gtaacctctt tatcaagtgc tttgtgctga agtgataata gctttttcat
    13681 ttgtttcacc tcctttaatg aacttgtcta tttcaaagag attcagatta ttgtttttag
    13741 gtaacggtaa ccaactactc catttatcac tatctatatc agaaagagca agtagtaatc
    13801 cgctgtttcc tgtttgtaag tctaaagata gtcggtaacc atactctcct ggacttaaaa
    13861 ttccttcgtg tttcttatac aggagataat ttccgagtgc tttaatggta tattctaatg
    13921 agcctgtatt tacccctgca catttcattg cattcgcaag aataatcatt cctcccacac
    13981 ctcgaaagat gccacttgca aatgtgctat ataagtctgt aacattagtt agttttttga
    14041 atagttcagt attactttct gtcataaaat caggaagatt tttattgaat tccagcataa
    14101 ttaatgcaat cccagctgca ccttcaccaa gatatggtat caacctttta tagcccaatg
    14161 aatattcttt tatttgtgct aattctaatt tagaatcaat ttcaatgttt ttgcttattt
    14221 ctttattgaa aatttcgcta gccagcttta ttaagtcatt gtcatttgtc gccttgccta
    14281 acattagaat atacaagctg attccagacc agccatttaa caagccatac ggcattgcat
    14341 aaggatccct tacagtgatg gagcagtctt ctttataggc atctattatt ctatttccta
    14401 tttttataga gcgatctaga aagtcttttt tctgagtaat gctataaaac gccaggtagt
    14461 ttaatccaat tcccgataat ccagaaaaca gtgttaaatc tgaatcttca gtatctggaa
    14521 aaggcattgt ctctaacagt ttaattgctt cttctttata tccaatatcg tataaaacgg
    14581 acaatatgcc tgagatacca ttaaataaac cgagcgggaa atttttatat gtttccgtgt
    14641 ctaaattcaa tattgtctcc aatacatgat caacccattg ataaactgaa tcggatagag
    14701 tccctgttct atccaaggcc attattcccc caaatcctcc attagcgatt gatagactgc
    14761 ccattttttc aatgaattgc ctgatatctc cggatattaa actttctgac ttaggtttta
    14821 aatgactcat aattccagct cgcaaacctt cagttatttc attaacattc ttgtagttta
    14881 ttttcattgg tggaattgtt aaagtagcag ctttacttaa tttcttgatg gttggtaatg
    14941 tcttctcttg aatttcttga attttattta aaacttcatc cccaaaattc tctccaatcc
    15001 atttatcttg atttatttca atatcaattg acagatcaga taaattttct atcggtaaaa
    15061 ataaaaacct gcaaattcta agtaatgcat accaatctgc ttgctcaaaa gtttctgctt
    15121 gatccgtaac gtaaccagga gtcattaagg cgggggtgta tttgctttcg ggagttacag
    15181 cagtttctag gtctattaat ttgattgagt aatcctctaa taccaataca ttatttggct
    15241 gtaagtctcc gagtgcaatc ttacttctat gaagatcttt taaagcatca atcaactgat
    15301 ctatcacatg catcatgcgt tccatataaa tatctttatc ttctttatat gaaaacggaa
    15361 agttttgaga tacatattcc ataagagaaa ttcctgatac atgttcttca atcaaatagt
    15421 tattttccca aatctcaaag taatcgtaaa aatcaactat gtaaggcttc tcacttaatt
    15481 gctttattgt ttcagcctct ttataaattc gtttaaaacc atctagtttc aaccgatcca
    15541 aacctgaacc aagtcttcct tctttcataa caaacgtttt cccgtttttt tcaactttat
    15601 atactccacc accattgcta aaatgcagtg cagaaataac attgtatgaa tcaaacttcg
    15661 atgtgtcttc tttatcaagt tctgcatcaa cttttttagt catgatttgt atttcaacag
    15721 gttcttcaac aaagtcagga acttcataat atggagcacg gacatctgga attaatgtgc
    15781 catcaggtcg ctgaattgct ggaacatttt gtccatcttt attcacatac atagatacaa
    15841 atgctccata acgaaagaag acatttgaat acttccagcg tttatcattc aatatataag
    15901 gacctttttt taaagcttta gtcagattat ctaaatctga aagtaatgtt agaaaagtct
    15961 tgttatcata aggatagatt gtaatgaatt tacccgaaga tg
//
