LOCUS       gnlProkkaJIHPFFOD_5    12575 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|JIHPFFOD_5.
ACCESSION   gnlProkkaJIHPFFOD_5
VERSION     gnlProkkaJIHPFFOD_5
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2025-04-28 08:30:51
            Original ID  :: gnl|Prokka|JIHPFFOD_5
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 27694
            Orig. end    :: 40269
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..12575
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="True"
                     /core_location="[10000:12556]"
                     /cutoff="10000"
                     /detection_rule="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /neighbourhood="10000"
                     /product="RRE-containing"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..12556
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /neighbourhood="10000"
                     /product="RRE-containing"
                     /protocluster_number="1"
     cand_cluster    1..12575
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /kind="single"
                     /product="RRE-containing"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..12575
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="RRE-containing"
                     /region_number="2"
                     /rules="minimum(1, [Bottromycin_Methyltransferase_RRE,
                     Cyanobactin_D_RRE, Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /tool="antismash"
     CDS             1266..2069
                     /NRPS_PKS="Domain: PKS_KR (11-172). E-value: 3.5e-08.
                     Score: 25.4. Matches aSDomain:
                     nrpspksdomains_ctg5_35_PKS_KR.1"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) adh_short"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1001:short-chain dehydrogenase/reductase SDR (Score:
                     187; E-value: 7.1e-57)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg5_35"
                     /sec_met_domain="adh_short (E-value: 7.7e-33, bitscore:
                     105.5, seeds: 230, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSENWLNLNEKVYIVTGGSSGIGEAIVKELLNDGAYVYDADLQPA
                     KEEHDHLTFVETDVTNKGQVDALVARVVEEHGHVDGVVNNAGINLPRLLVDAKESNSKY
                     ELTENDFDKMFNVNVKSVFLMSQAVARQLVKQKSGVIVNMASEAGLEGSQGQSIYSGTK
                     AAIVGLTRSWAKELGEFNVRVVGVAPGIMEATGLRTLAYEEALAYTRHKTVEDVRAGYK
                     SKSTTPLGRSGKLSEVADLVAYYLSDRSSYITGVTTNVAGGKSRG"
     CDS_motif       1299..1370
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ctg5_35_0001"
                     /evalue="8.90E-06"
                     /label="PKSI-KR_m1"
                     /locus_tag="ctg5_35"
                     /protein_end="35"
                     /protein_start="11"
                     /score="18.4"
                     /tool="antismash"
                     /translation="VYIVTGGSSGIGEAIVKELLNDGA"
     aSDomain        1299..1781
                     /aSDomain="PKS_KR"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg5_35_PKS_KR.1"
                     /evalue="3.50E-08"
                     /label="ctg5_35_PKS_KR.1"
                     /locus_tag="ctg5_35"
                     /protein_end="172"
                     /protein_start="11"
                     /score="25.4"
                     /specificity="KR activity: inactive"
                     /specificity="KR stereochemistry: C2"
                     /tool="antismash"
                     /translation="VYIVTGGSSGIGEAIVKELLNDGAYVYDADLQPAKEEHDHLTFVE
                     TDVTNKGQVDALVARVVEEHGHVDGVVNNAGINLPRLLVDAKESNSKYELTENDFDKMF
                     NVNVKSVFLMSQAVARQLVKQKSGVIVNMASEAGLEGSQGQSIYSGTKAAIVGLTRS"
     CDS             2085..3944
                     /locus_tag="ctg5_36"
                     /transl_table=11
                     /translation="MNVLNYQLFKILTTNDSITVDRLVSELQVSKKTLQKYITSLNEEL
                     GEIAEIQEKNQKYYLKVEDYARLAKFQTHYLKTTLDFNNPLKRQAYILLMLIKSKGYML
                     LDDLSEYLMVSKGTINRDIKEIKLLLKDYDTTIRSVSNNGVMLESKEDCQIAFILRNFV
                     CDYYDLGEKLAIEEKQEITKLVRKYDKSKTVRNLIIRHLKILNFLHEHGRKISTTPDCY
                     YELTSSEVNDEILSILKKYLHSKEITEAEKSFLLIPLNINYSNRNTERINKRLMWIDEL
                     FAEIFSQVKENISLDIDYNRVFEQIKYHSIFMINRSATYMRNDDLFSREIVEKYPVAVD
                     LAIMTVNLLESKLHIKISDKELGYLALYYQMEIEDEKRGNPQYHKVAIVGEVSKSIQNL
                     IISRLNETFQGTTEADVFKSSESFKKSSERYLIVFSTLPLESKDVTTPIVRIQSIFKND
                     ELVSKVTLSQVMAGISSQQVKFRIQRFEERISYLKAVENLIDTEISTGELLPEFKLDWK
                     KREEKMSNVFQNGIAIPHMVDKSNHSRILLTVGILSKAVKYQGKEVRIIFLIGIPQNLN
                     SKLSKILSRVYDLIFMISGYDEIYNNLLEYDMDLPLTQITEGI"
     CDS             3945..4442
                     /locus_tag="ctg5_37"
                     /transl_table=11
                     /translation="MIILIGLIVVGAFLLQGLFGIFQIKNFSRNYRELRLLGPYRILIG
                     KNPKRFFSGSLMLIAIDNDGNIKEARLMQGVTVFAKFRTLKKLEGKNIAVLAADYQELK
                     RMNKLTRQCLLNAYKTFVDFKTQKLSASAYDTSVNVFNMPLFTKIGLMANNLKANMSKK
                     FN"
     CDS             4454..4996
                     /locus_tag="ctg5_38"
                     /transl_table=11
                     /translation="MDIVVNLASGFMNLFETGGKTFIGWMKTIVPVVLLLLVLMNTIIA
                     FLGEEKMDKIARGASKNIFTRYLILPFLSAFMLGNPMSFTMARFLPEYYKPSYYAAQAQ
                     FCHTSNGVFPHINPGELFVWMGIAQGVQKLGLNSMDLAIRYLLVGLVMNFIGGWVTDFT
                     TAYVCRTTGIKLSKTVD"
     CDS             5013..6038
                     /locus_tag="ctg5_39"
                     /transl_table=11
                     /translation="MSKWNSIKIVKGSGGWGGPIVVTPTEEKHKVVYVTGGNRPDIVDT
                     IVELTGMEAIDGFKTAIPDEEIALAIVDCGGTLRCGIYPSKNILTVNVLPTGKSGPLAK
                     YITPELYVSAVTPKQISLVNAEDAEAIVKQQNEKATKEEVADDKEDGIDTSKTLTQQGH
                     GGGFIAKIGIGVGKVVATFNQAAKESVQTVLNTIIPFMAFVALLIGIIMGSGIGNWFAK
                     IMVPLAGNVWGLMILGFICSLPFLSPLLGPGAVIAQVIGTLIGVEIGKGHIPPQYALPA
                     LFAINTQNACDFIPVGLGLEEAKPETVEVGVTSVLYSRFLNGLPRVFVAWLASFGLYSG
                     K"
     CDS             6075..6455
                     /locus_tag="ctg5_40"
                     /transl_table=11
                     /translation="MFLQKKKTKLYETEVIEIGEEAKNFKEIKMVILFGEGAPDALRPS
                     CYIIKVNELSGEIKAGMTLQIDDEKYKITAVGNEVQTNLKNLGHIAINFTGDKTATLPG
                     SMYVEEKEYPKINEGTKIAIIK"
     CDS             6522..7202
                     /locus_tag="ctg5_41"
                     /transl_table=11
                     /translation="MEFLLDTVDLKKIKYYCDKLNVKGVTSNPTILKKDGVGDDLFAHL
                     KKIKEIIEDERELHVQVVAPSVSGMIDEAHKIVDEVGKDVYIKVPTTLDGLEVMKKLKA
                     EGIRVTATAIYTEFQGYQAINVGADYLAPYYNRMLNQNINSAEVIRNLSKRINLDNSNT
                     KILAASFHNVAQVNEALSNGAQAVTVGPDIVASAFKMPSISQAMADFRNDWESLYGDKN
                     INNL"
     CDS             complement(7265..8260)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) 2-Hacid_dh_C"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1072:dehydrogenase (Score: 307.9; E-value: 9.3e-94)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg5_42"
                     /sec_met_domain="2-Hacid_dh_C (E-value: 8.5e-54, bitscore:
                     173.1, seeds: 135, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MVSIKMFGVRDEERPMAENWAKEHNVKIDMTSDILTSDTIDEVKG
                     FDGLTLMQVAEVTDDLYPKLKEFGIKQIAQRSAGYDMYNLDAAKENGIIITNVPSYSPE
                     SIAEYTVTTALNLVRKFPLIEKRVKEHNFSWEPEIRGRVIGDMTVAVIGTGRIGYHVAK
                     IFHGFGAKVVGYDLYPSDKLDGILEYRDSVEDAIRDADIISLHMPAFKENHHMFNYEMF
                     KKFKSDAVLVNMARGALIDTEDLLKALDDGLLAGAGLDVYEHEGPLVPIDLTGKDIEDE
                     TFKKVLESDKIIYSPHVAYYTDEAVRNLVEGGLNATLEVLETGDASTRVN"
     CDS             8467..9516
                     /locus_tag="ctg5_43"
                     /transl_table=11
                     /translation="METTKITPKVFIDRVLGGTAIGIIVGLIPNAVLAAILKMFGTNPF
                     AVHLGQAAIIFQLGTPLIIGTLIAQKFGFDGMKMTVVGGAAFVGSGVIKYFPALNKTGA
                     YVGAGTGDIINTMLTASIAVGLILLIGDKFGSVAIVLTPIVVGTGAGLIGFYMYPYVTA
                     ITSAIGNVINTFTELQPVLMCILIACSFAVLIISPISTVAIAMAIQVNGLAAGAAAMGV
                     AATTLVLVVNSWKVNKPGVTIAIALGAMKMMMPNLFRRPIILVPCFFTAIISAVPVALM
                     SISGSPASGGFGLVGLVGPLASIEKGLGVVAALLAWLVIPVIASLVGQFLFEKVFKLYD
                     RKDVFEFLG"
     CDS             9742..9921
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) TIGR03731"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) mature_a"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg5_44"
                     /sec_met_domain="TIGR03731 (E-value: 1e-16, bitscore: 52.3,
                     seeds: 23, tool: rule-based-clusters)"
                     /sec_met_domain="mature_a (E-value: 3.1e-07, bitscore:
                     21.4, seeds: 5, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSVNDFKLDLVKVSKESTNSNYSVKITSYSLCTPGCKTGALMGCT
                     MKTASCGCHVHISK"
     CDS             10001..12556
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RRE-containing: Lanthipeptide_LanB_RRE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Lant_dehydr_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Lant_dehydr_C"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1155:Lantibiotic dehydratase domain protein (Score:
                     676; E-value: 1.4e-204)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg5_45"
                     /sec_met_domain="Lant_dehydr_N (E-value: 2.8e-90, bitscore:
                     294.7, seeds: 73, tool: rule-based-clusters)"
                     /sec_met_domain="Lanthipeptide_LanB_RRE (E-value: 3.9e-12,
                     bitscore: 38.4, seeds: 20, tool: rule-based-clusters)"
                     /sec_met_domain="Lant_dehydr_C (E-value: 6.6e-18, bitscore:
                     56.8, seeds: 35, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNNFNVSDVMIRNTIQTYEKSQNFNNYKEFIEIIKNDNIFLEQIL
                     LANPKLYGMLKKYNAGKLKKKKEKNFFESIYKYYKRSYYRATPFGLFSETSNGKFTVKG
                     DKKELGKTHKVVFIDIKWLTDVIFKLEKDYQSNLSFISNNGNYISGNRVMQLYSINDQD
                     LEEVSINNSKVYRIISEECSQTYKTYSEIIEKVITIYGNEYLNLTKEYINDLVENHYLI
                     SNLQENILINFSMSDFIMKVREIDVSKKYVEILTKIQELIEEYTHIEIGSGSDKLIEIY
                     HQMARLNKSDNYIQVDLYNDGNIYIDNSNKQRIEKFSNFITNTVKSVTRTYFDDYKDKF
                     IEKYGIDQDVQLIELFDPIKGIGAPYDYTHPQNEVFELEPPTSYYSHDEKEMYINKYIE
                     ALLNREEINLKCFSNYYRNLNSKESTSIQGIELFFHMVQINKKKTLALSNIIGSNNIGG
                     SSGRFSLLSDKLRDYHMKTLKQVKAANIEEGVTSCEIVFLPENIRHANIMRTSFVREKV
                     LPIFSSTDQSEVRLTNIYIGLDENENFYAYDVSTQEKMKFYVTSMYNKTLFSNELRFLC
                     EISINNNFGYVPWDLIYKDMNFIPRIMFEDIVVSPKTWRIFKFELSNIAIESIIKQRNI
                     PNEIYIVDGDNKLYINRKNSLDVELFMSEIKRNIEKNGHAIIQEYFNNKDMIYKDSEGK
                     ISEIVVPVINSKFDVKKVNKEKQQRISKHVREKLPFNDWLYLKVYMSTRRQEEFIRVYI
                     PLIQKKVEKLDGKLFFLRYMDPVPQIRIRISGNNLYKIYEVIKKDLEQGHRNGILSTFD
                     ISTYDREIERYGGVNAIDIAENIFCEDSKLVIKYLKFIK"
ORIGIN
        1 agtaaggtta gtatcccatt attagctaaa actgcaacaa aaaggaaaag taaggtagtc
       61 attaacaact caaacatctt tattaaagaa ttaagagggt tagtattagc aaaacgtcct
      121 cctaaagtat tgccaatagc gaccattact ccgtaaataa ctaaaataat aacaatggcg
      181 tttgctgaaa agcctactcc ttctaataat ggagaaagat aagtatatgc tgcaaaagtt
      241 cctccatagc caaaagcagt aatcaggaat gatagaacta aaggtttgtt agtaaagata
      301 cgaataaaac catgcaaatc tacttttcca ggaattggta aagatttagg aattagaaaa
      361 taatcagcaa ttaaaccaat aagtcccacg gtagcgatga agataaaaga catattccaa
      421 gaagtttgtt gaccaataaa agtacccaaa ggaacacctg taacagttgc aacagttagt
      481 ccggtaaaca taattgcaat agcactagca cgacgagatg gttcaactac atcagcagct
      541 ataactgttg aaattgacat gaatattcca tgagctaaag cggctaaaat tctacccaat
      601 agtaaaatag caaaaaacgg agcaaaagct gcaagtaaat tacctattat aaataaagtc
      661 atgattccta gcattaagga atggcggctc catttaccag ttaaaatcgt taacaaaggt
      721 gcgccaatag ttacgcctaa agcatacaat gaaacagtta gtccagcttg agataaacta
      781 atattgaaac ttttaacgat cattggaagt aatccaacgc taataaattc agtagaacct
      841 attgcaaaag cattaatagc cagtgcaaat aatgttaaac gaggtgaaat tttattcatc
      901 ttaaaaattc tttcctttca tatattaagt tgatgaagat aatatatact atttagttac
      961 tttttgtaag tacgaacttt aaagtaacat aggtactttt tagtaacttt tgtgtaagtt
     1021 agagaaaata ggaaagaaaa aataataata tcgtattaaa ggatataaga tgataaaaaa
     1081 tattatttaa aataattacc tactatatat tgatttaaat ttatgttaac tgtataattt
     1141 tatttaaata tttaattcat gcaatatttt tctcagattt tagaaattct tggtattaat
     1201 tgttgtaacc gttaacacta aaataagaat tgtaataaag atataaagtt attggaggaa
     1261 ttcttatgag tgagaactgg ctgaacttaa atgaaaaggt gtacattgta acaggtggtt
     1321 cttctggtat cggggaagca attgtaaaag aattattaaa tgacggcgca tatgtatatg
     1381 atgcagattt acaaccagct aaggaagaac atgatcattt aacatttgta gagacagatg
     1441 taacaaataa aggacaagtt gatgcattag ttgctagagt tgttgaagaa catggacatg
     1501 ttgatggtgt tgtaaataat gcaggtatta acttaccaag attgttagta gatgctaagg
     1561 aaagcaatag caaatatgaa ttaactgaaa atgattttga caagatgttt aatgtcaatg
     1621 taaagagtgt atttttgatg tcacaagctg ttgctcgtca attagtaaaa caaaaatcag
     1681 gtgtaattgt taatatggct tctgaagctg gtctggaagg ttcacaagga caaagcattt
     1741 attcaggaac taaagcagca atcgtaggtt taacacgttc atgggcaaaa gaattaggtg
     1801 aattcaatgt tcgtgtagta ggtgtagctc ctggaattat ggaagcaaca ggtttaagaa
     1861 cactagctta tgaagaagct ttggcatata caagacataa aacggttgaa gatgtccgtg
     1921 caggatacaa gagtaagagt actacaccat taggaagaag tggtaaatta tcagaagttg
     1981 ctgatttagt tgcctactac ttatcagaca gatcaagtta tataacaggt gttacaacaa
     2041 acgttgccgg aggaaaatct cgcggataga aagtgggata ggttatgaat gtattaaact
     2101 atcaattgtt taagattctt acgacaaatg attcgattac agtagatagg ttagttagtg
     2161 agttacaggt atctaagaaa actttacaaa agtatataac gagtttgaat gaagaattag
     2221 gcgaaatagc tgagattcaa gaaaaaaatc aaaaatatta tttgaaagtc gaagattatg
     2281 ctagattagc taaatttcag acgcattatt taaagacaac tttggatttc aataatcctt
     2341 taaaacgtca agcatatata ttattgatgc tgattaaatc taaaggatat atgttacttg
     2401 atgatttatc tgaatatttg atggtaagta aaggtacaat caatcgtgat attaaagaaa
     2461 taaaacttct attaaaagat tacgatacta ctattcgatc ggtaagtaac aacggagtaa
     2521 tgttagaaag taaggaagac tgtcagattg ctttcattct acgtaacttt gtttgtgact
     2581 actatgattt gggtgagaaa ctagcaattg aagaaaagca ggaaataacc aaattagtta
     2641 gaaagtacga taaaagtaaa acagtacgta atttaataat aagacatttg aaaatactta
     2701 acttcttaca tgagcatggt agaaaaattt caacgacgcc agattgttat tatgaattaa
     2761 ctagttctga agtaaatgac gaaattctat ctatattaaa gaagtattta cattcaaagg
     2821 aaataacaga agcagaaaaa agcttcctat taataccact gaatatcaat tatagtaata
     2881 gaaatactga acgaataaat aaacgcttga tgtggataga tgaattattt gcagaaattt
     2941 ttagtcaagt taaggaaaat atcagtctag atattgatta caatcgagtc tttgaacaga
     3001 taaagtatca ttcaattttc atgataaata gaagtgccac atatatgaga aatgatgatc
     3061 tattcagtcg agaaattgtt gaaaaatatc cagtggcagt agatttagct attatgacag
     3121 ttaatttatt agaaagtaaa ctgcatatta agatttcaga taaagaattg ggttatttag
     3181 cactttatta tcaaatggaa atagaagatg aaaaaagagg gaatcctcaa tatcataaag
     3241 ttgcgattgt tggtgaagta agtaaaagta ttcaaaattt gattattagt aggttaaatg
     3301 aaacttttca aggaacaact gaagcagatg ttttcaagag tagtgaaagt ttcaagaaat
     3361 cgtccgaacg ttacttgatt gtattttcaa ctttaccact tgaaagtaaa gatgttacaa
     3421 ctccaattgt tagaattcag agtatcttta agaatgacga attagttagc aaagtaactc
     3481 tatcgcaagt tatggcggga attagtagcc aacaagtaaa atttagaatt caaagatttg
     3541 aagaaagaat ttcctatttg aaagctgttg agaatttaat tgatacagaa atttcaacag
     3601 gtgaattatt accagaattt aagctagatt ggaagaaaag agaagaaaaa atgagtaatg
     3661 tcttccaaaa tgggattgca attccgcata tggttgataa atctaatcat tctagaatat
     3721 tgttgacagt tggcatctta tcaaaagctg taaaatatca gggaaaagaa gtaagaatca
     3781 ttttcttaat aggtataccg caaaatctaa actctaaatt gagtaagatt ctgtctcgcg
     3841 tatacgactt aatctttatg atttcaggat atgatgaaat ttataataat ttgttggaat
     3901 atgacatgga tttaccatta acacagataa cggagggaat atagatgatt attttaatag
     3961 gattgattgt tgtaggggcg tttctcttac aaggattgtt tggaatcttt caaattaaaa
     4021 atttttccag aaattatcgt gaactaagat tactaggacc ttatcgcatt ctgattggta
     4081 aaaatcctaa acgcttcttt tcaggttcat tgatgttgat agcgatagat aatgatggaa
     4141 atataaaaga agctcgttta atgcaagggg ttacagtgtt cgctaaattt agaacattga
     4201 agaaactcga aggtaaaaac atcgcggttt tagctgcaga ttatcaagag ttaaagagaa
     4261 tgaataaatt gactagacaa tgtttattga atgcttacaa aacttttgtt gattttaaga
     4321 cacaaaaatt gtcagcaagt gcttacgata caagtgtaaa tgtgttcaac atgccattat
     4381 ttacaaagat tggtttaatg gcaaacaatt tgaaggcaaa tatgtcaaag aaatttaatt
     4441 aggagatgat ctcatggata tagttgtaaa tcttgcatca ggttttatga acctctttga
     4501 aacaggtgga aaaacattca ttggttggat gaagacaatc gtaccagttg tattgctatt
     4561 attggtttta atgaatacaa ttattgcatt cttaggtgaa gaaaagatgg ataagattgc
     4621 tagaggggca tctaagaaca tctttacacg ttatctaatt ttgccattct tatcagcatt
     4681 tatgttaggt aatccaatgt cctttacaat ggctcgtttc ttacctgaat actacaagcc
     4741 aagttactac gctgcacaag ctcaattctg tcatacaagt aatggggtat tccctcacat
     4801 caatccaggt gaattgtttg tatggatggg tatcgcacaa ggtgtacaaa aattaggttt
     4861 gaatagtatg gacttagcta ttagatactt attagtaggt ttagttatga acttcatcgg
     4921 tggttgggta actgacttta caactgctta tgtatgtcgc acaactggaa tcaagttatc
     4981 taagacagtg gattaattgg aggtaatgaa ctatgagtaa atggaacagt attaaaatcg
     5041 taaaaggctc aggtggttgg ggtggtccaa tcgttgtaac accaacagaa gaaaaacata
     5101 aagtagttta tgtaacaggt ggtaatagac cagatattgt tgatacaatt gttgaattaa
     5161 caggtatgga agctattgat ggttttaaga cagcaattcc tgatgaagaa atcgcattag
     5221 caatcgttga ctgtggtggt accttacgtt gtggtattta cccaagtaaa aatattttaa
     5281 cagtaaatgt tcttccaaca ggtaaaagtg gtcctttagc taaatacatt actccagaat
     5341 tatatgtatc tgctgtaact ccaaagcaaa tttcattagt aaatgctgaa gatgcagaag
     5401 caattgttaa acaacaaaat gaaaaggcta ccaaagaaga agttgcagat gataaagaag
     5461 acggaataga tacttctaaa acattgacac aacaaggtca tggtggcgga tttatcgcta
     5521 agattggtat tggtgtaggt aaagttgttg ctacatttaa ccaagctgct aaggaatcag
     5581 tacaaacagt tttgaataca attattccat ttatggcatt tgttgctttg ctaatcggta
     5641 ttatcatggg ttccggtatt ggtaactggt tcgctaaaat catggtacct cttgcaggta
     5701 acgtttgggg cttgatgatt ttaggtttca tttgttcatt gccattctta tcaccattgc
     5761 ttggaccagg tgctgtaatt gcccaagtta tcggtactct aattggtgtt gaaattggta
     5821 aaggtcatat tcctccacaa tatgcattac cagcattgtt cgctatcaat actcaaaatg
     5881 cctgtgactt cattcctgtt ggtttaggtc ttgaagaagc taagccagaa acagttgaag
     5941 ttggggttac atctgtattg tactcacgtt tcttaaacgg tttacctcga gtatttgtag
     6001 catggttagc tagtttcgga ttatattcag gaaaataaaa gtaaaaatga attgatgatg
     6061 aggtgtgatt tgttatgttc ttacaaaaga aaaagactaa gctttatgaa acagaagtta
     6121 tagaaattgg tgaagaagct aagaatttca aggaaattaa gatggttatc ttatttggtg
     6181 aaggggctcc agatgcactt agaccatcct gctacatcat taaagtaaac gaattatctg
     6241 gtgaaataaa ggcaggtatg actttacaaa ttgacgatga aaaatataaa ataacagcag
     6301 taggtaacga agttcaaact aacttgaaga acttaggtca tatagccatt aacttcacag
     6361 gggataaaac tgctacatta ccaggatcaa tgtacgtaga agaaaaggaa taccctaaaa
     6421 ttaatgaagg tacaaagatt gctattataa aataaattag ggaagcatag ggagcgttga
     6481 ggtttctcta tgcttttcta gcatgaaagg acaaaataga tatggaattt ttattagata
     6541 cagttgattt gaaaaagatt aaatattact gtgataaatt aaatgttaaa ggagtaactt
     6601 ctaatccaac gattctaaaa aaagatggag taggcgatga tttattcgca catcttaaaa
     6661 aaataaagga aatcattgaa gatgaaagag aactccacgt acaagttgtg gcaccttcag
     6721 tatctggaat gatagatgaa gctcataaaa ttgtagatga agtaggtaag gatgtataca
     6781 tcaaagttcc aactacttta gatgggttag aagtcatgaa aaaactaaag gctgaaggaa
     6841 ttagggtaac agcaactgca atttatacgg aatttcaagg ttatcaagca atcaacgttg
     6901 gtgctgacta cttggctcct tactataata gaatgttaaa tcaaaatatt aattcagctg
     6961 aagttattag aaatctatct aaaagaatta atttagataa tagcaatact aaaattttag
     7021 ctgcaagttt ccataatgta gcacaagtaa atgaagcatt aagtaatggt gctcaagctg
     7081 taacagttgg tcctgatatt gtagcatctg cttttaagat gccgtctatt tctcaagcta
     7141 tggcagattt tagaaatgac tgggaaagtc tatacggtga taaaaatata aataacttat
     7201 agtaagtata taacaaaaaa cctctgagat ggattctcag aggcttttat taggattaaa
     7261 ctaattagtt tacacgtgtt gaagcatcgc cagtttccaa tacttccaaa gtagcattta
     7321 agccaccttc aactaagttt ctaacagctt catcagtgta gtatgctacg tgtggtgagt
     7381 agataatctt atcagattca agtactttct tgaatgtttc gtcttcaata tcttttccag
     7441 ttaggtcaat aggaactaat ggaccttcgt gttcgtaaac gtcaagacca gctccagcca
     7501 aaaggccatc atctaaagct ttcaataaat cttctgtatc aattaaagca ccacgagcca
     7561 tgttaactaa tacagcgtca gatttgaatt tcttgaacat ttcgtagtta aacatgtggt
     7621 ggttttcctt gaaagcaggc atatgtaaag aaataatgtc tgcatcgcgg attgcatctt
     7681 ctacagaatc acgatattcc aagataccgt ctaatttgtc actaggatat agatcatatc
     7741 cgacaacttt agcaccaaaa ccatggaaga ttttagctac atggtaacca atacggccag
     7801 ttccgataac agcaactgtc atgtcaccga taacacgacc tctgatttca ggttcccatg
     7861 agaaattatg ttccttaaca cgtttttcaa ttagtgggaa tttacgtact aagttcaatg
     7921 ctgtagttac agtatattca gcaattgatt ctggggagta gctaggcaca ttagtaataa
     7981 taatgccatt ttctttagca gcatctaaat tgtacatatc ataaccagca ctacgttgtg
     8041 cgatttgttt gataccaaat tctttcaatt taggatataa gtcatctgta acttctgcta
     8101 cttgcattaa agttagaccg tcaaaaccct taacttcatc gatagtatca gatgtaagga
     8161 tgtcactagt catatcaatt ttaacgttgt gttcctttgc ccagttttca gccattggac
     8221 gttcttcatc acgaacacca aacattttga ttgaaaccat taaaaattcc tcctcatata
     8281 aatgataacc tttacaatat atattatatc atcattataa cagaatactt aaatataagt
     8341 gttaaattta attaattttt tacgtttttt tctaataaaa gaaagaaact aaagaaaaat
     8401 atatttacat tgctcacaat ctcacttata ataatgtgta tattttatat aaagaaggtg
     8461 acgaatttgg aaacaacaaa gattacaccc aaagttttca ttgatcgtgt tttaggcggt
     8521 actgccatcg ggattatagt tggtttaatt cctaatgctg ttcttgccgc tatcctcaag
     8581 atgttcggca ctaatccttt tgccgtacat ttaggacaag cagcaattat tttccaatta
     8641 ggaacacctt taattattgg tacattgatt gctcaaaagt ttggctttga tggcatgaag
     8701 atgaccgtag ttggtggagc cgcatttgta ggttctggcg taattaaata cttcccagcg
     8761 ttgaataaaa caggtgccta tgtaggtgct ggaacagggg atattattaa taccatgtta
     8821 acagcatcga ttgcagttgg attaattctg ttgataggcg ataaatttgg atcagtagca
     8881 attgttttaa caccaattgt agtaggaaca ggtgctggct taattggatt ctatatgtat
     8941 ccatatgtta cagcgataac ttccgcaatt ggtaatgtga ttaacacatt tacagaatta
     9001 caaccagttt taatgtgtat tttaattgcc tgctcttttg cagtgttaat tatctctcca
     9061 atttcaacag tagcgattgc aatggctatc caagttaacg gcttggctgc tggtgctgct
     9121 gcaatgggag ttgctgcaac aacacttgta cttgtagtaa actcatggaa agttaacaag
     9181 ccaggggtaa caattgcgat tgccttaggt gcgatgaaga tgatgatgcc taacttattt
     9241 agacgtccaa ttatcttagt accatgtttc tttacagcaa taatttctgc agttcctgta
     9301 gctttgatgt caatttcagg ttctcctgct tccggtggtt ttggtttagt aggtttagta
     9361 ggaccattag catcaattga aaaaggctta ggcgttgtcg cagcattgct agcatggtta
     9421 gttattccag ttattgcgtc acttgtcggt caattcttat ttgaaaaagt atttaagtta
     9481 tatgaccgca aagatgtttt tgaattttta ggttagaaaa tattagaatt gaatctaatt
     9541 aaaaatagtt taagttaaga aaatgctgaa ggttacattg ctgaaatgtt aatctttggc
     9601 attttttatt ttaaagattt ttccatggtt ttaaaattat cagtttaaat aatatgtatt
     9661 ctgaacaaaa tctgaaaata ataacatatt atagtgacgt tctagaacaa acaattaaag
     9721 ggttattagg aggttttcta aatgagtgtt aatgatttta aattggattt agtaaaagta
     9781 tcaaaggaaa gtacaaattc aaattattca gttaaaatta caagctactc actttgtacc
     9841 ccaggttgca aaacaggtgc actaatggga tgtacaatga aaactgcatc atgtggttgt
     9901 catgtacata taagtaaata gtaagaaagt aagggatagc gtagatcaat ttgatgattt
     9961 gctatcccat ttttttaata ggtgaaaggg gcttgaaaaa atgaataatt tcaatgttag
    10021 tgatgtaatg atacgtaata caattcaaac atatgaaaaa agtcaaaatt tcaataatta
    10081 taaggaattt attgaaatta ttaaaaatga taatattttt cttgaacaaa tattattggc
    10141 taatcctaag ctgtatggaa tgcttaaaaa gtataatgca ggaaaactaa agaaaaagaa
    10201 agaaaaaaat ttttttgaat caatatataa atattataaa aggagctatt atcgagcaac
    10261 tccttttgga ctatttagtg aaacttctaa tggtaaattt accgttaagg gtgataagaa
    10321 agaattaggg aaaacacaca aagtagtttt tatagatatt aaatggttaa cagatgtaat
    10381 ttttaaatta gaaaaggact atcaatcaaa cttatctttc atatctaata atggaaatta
    10441 cattagtgga aatcgtgtta tgcaattata ttcaataaat gatcaagatt tagaggaagt
    10501 tagtattaat aactctaaag tttatcgaat tatatcagaa gagtgtagcc aaacttataa
    10561 gacatatagt gaaatcatag aaaaggttat aacaatatat ggtaatgaat acttaaattt
    10621 aacaaaagaa tatattaatg atttagtaga gaatcattat ctaatatcaa atttacaaga
    10681 aaatatacta attaattttt ctatgtcaga cttcataatg aaagttaggg aaatagatgt
    10741 tagtaaaaaa tatgtagaaa tattaacaaa gatacaagag ttaattgaag aatatacaca
    10801 tattgaaata ggttcgggtt ctgataaatt aattgaaata tatcaccaaa tggctagact
    10861 taataaaagt gataattata ttcaagtaga tttatataat gatgggaata tatatattga
    10921 taatagtaat aaacaaagaa tagagaaatt ttcaaatttt ataactaata ctgttaaatc
    10981 agtaactagg acttattttg atgactataa agataaattc attgaaaaat atggtattga
    11041 tcaagatgtg cagttaatag aactatttga tccaataaaa ggaattggcg caccgtatga
    11101 ttatacgcat cctcagaatg aagtttttga attagagcct ccaacgtcat attattccca
    11161 tgatgaaaaa gaaatgtata ttaataaata tatagaagct ttattaaata gagaggaaat
    11221 taatttgaaa tgcttttcta attattatag aaatctgaat tccaaagaaa gtacctcaat
    11281 acaaggaata gaattatttt ttcatatggt ccaaattaat aagaagaaaa ctttagcatt
    11341 aagcaatatt ataggcagta ataatatagg gggatcctct ggaaggttct cattattatc
    11401 agataaatta agggattatc acatgaagac acttaaacaa gtgaaagctg caaatattga
    11461 agaaggggtg acgtcttgtg aaatagtttt tcttcctgaa aatatacgac acgctaatat
    11521 aatgcgaaca tcttttgtaa gagaaaaagt tcttcctatt ttctcaagta ctgatcaatc
    11581 tgaagtaagg ctaactaata tttatattgg attagatgaa aatgaaaatt tttatgcgta
    11641 tgatgtgtct actcaagaaa aaatgaagtt ttatgtaaca agcatgtata acaagacatt
    11701 atttagtaat gaactaagat ttttatgtga aatttcaata aataataatt ttggatatgt
    11761 accatgggat ttaatctata aagatatgaa ttttattcca cgaattatgt ttgaggatat
    11821 agtagtcagt cctaagacat ggagaatatt taaatttgaa ttaagtaata tagcaataga
    11881 gtcgattata aagcagagaa atataccgaa tgaaatttat attgttgacg gtgataacaa
    11941 actatatatt aatcgtaaaa attcacttga tgttgaactg tttatgtcag aaataaaaag
    12001 aaatatagaa aagaatggtc atgccattat acaagaatat tttaataata aagacatgat
    12061 atataaagat agtgaaggaa aaatatcaga gatagtggtt ccagttatta atagtaaatt
    12121 cgatgttaaa aaagtaaaca aggaaaaaca acagagaatc tccaaacatg ttcgagagaa
    12181 attgccattc aatgattggt tatatctaaa agtgtatatg tcgactagga gacaagaaga
    12241 gtttatacga gtttacatac ctctgattca aaaaaaggta gaaaaattag acggaaaact
    12301 atttttctta cgttatatgg atccagtacc acaaataagg ataaggataa gtggtaataa
    12361 tttatataaa atatatgaag ttattaaaaa agatttggag caaggtcata gaaatggtat
    12421 tttatcgact tttgatattt ctacatatga tcgcgaaatt gagagatatg gaggagttaa
    12481 tgcaatagat atagctgaaa atattttctg tgaagattct aaacttgtaa taaagtattt
    12541 gaaatttata aagtaaacac actatagtgt gacat
//
