LOCUS       gnlProkkaNECODGLP_111  15007 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|NECODGLP_111.
ACCESSION   gnlProkkaNECODGLP_111
VERSION     gnlProkkaNECODGLP_111
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2024-11-17 05:04:48
            Original ID  :: gnl|Prokka|NECODGLP_111
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 15007
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..15007
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="True"
                     /core_location="[2040:5007]"
                     /cutoff="20000"
                     /detection_rule="cds(LANC_like and DUF4135)"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-ii"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      2041..5007
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="cds(LANC_like and DUF4135)"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-ii"
                     /protocluster_number="1"
     cand_cluster    1..15007
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="cds(LANC_like and DUF4135)"
                     /kind="single"
                     /product="lanthipeptide-class-ii"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..15007
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="lanthipeptide-class-ii"
                     /region_number="1"
                     /rules="cds(LANC_like and DUF4135)"
                     /tool="antismash"
     CDS             complement(541..1917)
                     /gene_functions="transport (smcogs) SMCOG1086:MATE efflux
                     family protein (Score: 335.5; E-value: 7e-102)"
                     /gene_kind="transport"
                     /locus_tag="ctg111_1"
                     /transl_table=11
                     /translation="MELLGSAPIPKALLAMGIPTMIGMMISAIYNLVDAYFVGGLGTSQ
                     MGAISVTYPLSQVIVGLGLLFGNGAGSYISRLLGRGNNDDAKKVASTALYSGLLLGIIF
                     IIGTLAFLEPILKFLGTTESIMPYAIKYARIFIAASIFNIFNVMMNNIITSEGAAKISM
                     FAMLSGALLNMILDPIFINVLNMGVTGAAIASAIGQALSTVVFLSYILMKKSIFTFKIK
                     DCCYSKENMKEILKIGVPTLVFQLLTSLSIILINNQANALSVTHTKEYVDSVIAGMGAV
                     TRIVSMGSLMVFGFIKGFQPIAGYSYGAKNFKRLNESIKTSILWSTVFCALFGLILILF
                     PATIISKFTAGDMELVRIGQASLRANGFSIMLFGFYTVYSSLFLALGKGLEGFILGACR
                     QGICFVPIILLLPSLVGISGILYAQPIADLISAIITVFMAINLHKSLEKERLSYIKNKE
                     "
     CDS             complement(2041..5007)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-ii: LANC_like"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-ii: DUF4135"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1070:lanthionine synthetase C family protein (Score:
                     610.8; E-value: 7.6e-185)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg111_2"
                     /sec_met_domain="DUF4135 (E-value: 1.6e-81, bitscore:
                     265.1, seeds: 79, tool: rule-based-clusters)"
                     /sec_met_domain="LANC_like (E-value: 9.2e-45, bitscore:
                     143.6, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRERYLFERKYIRKDNELKIPSKWEKLIGEDTVKILCKEYKEISS
                     FFSENTQYYEQEAPSNVEYMEILEMYLAGSYKSEIIIENTMKDKLFFTFYIPFFKLARY
                     YSRKKYGDILEKYFSKGIYEELYLALACVATRVLVNEIQFLENKLVGKNANEKYSTYVK
                     MYLSNDEYIEELFQFYPLLLRCILEKICSVVEFYHQLISRWEKNVIEIKKCINIDNTEI
                     TKIKKVGDNHRNGKHTVKIFLKNGNAVFYKPRNLRISKIYYECLNILYEYVGLSCFKYR
                     IADFGEYGWEEEIKYQKCKNKDEVKNYYIRMGCHIALSYILDIQDFHYENLISHGEYPV
                     FIDIEVLCGHITKNYIPLTANEKAKLFVENSVLGSGILPRGNKEMDIFCALSGKGGMKT
                     GRKRLLLINSKTSDMKFVYKDAKTKKGYNSPQINHKEYRYNGFVDEICLGFRKSYEYIW
                     KNNKIFEGRFQNFSSRMLYNHTQNYSKLIQLSYHPMFMTDGGERQLILSKNFFFHIQIN
                     PKNGKDLFESELYAMLKGDIPYFSFLSNKKELYMDNHQMIKEYFTITPEQYIKMRIKSL
                     SSQDLYIQQYLLNNAIKGSTVHLENRMDYMHDTNFSVIKICKQIADYLMKIGIKNSLKT
                     DINWIISLTGTIHISDMFLYEGIAGMIVFFAALNEVAPTRAYFEVQNILLNKLLEYTMN
                     NSSSKAYSGAFCGEASIIYTYLVLYKISNEEKYIKYAKIHENKLFASLEKDRMGDLLYG
                     NAGAVIIYLNMYELTMDKKYILRAEIAANYILKNLKETYSIFNNIEGNKISRLDRGIAH
                     GGSGYSICFTRLFGKTKKRKYLNIALELLKYDIIKNKKENQRSRKIYWCHGAAGIVLAQ
                     QEILKYIEDGSYQHIFEDYQTKISMIENNFNIELDSLCLCHGILGNIMIIQQLTGKIPC
                     VPWTSTLSKLNYFIEKNLWTNLENGNPGFMMGLAGIGYAVLYLDENSKKFPNILKLEL"
     CDS             5142..5666
                     /locus_tag="ctg111_3"
                     /transl_table=11
                     /translation="MATIDLIVLGMLKTSALSAYDIQKLVEYRNISKWVKISTPSIYKK
                     VLQLEEKGLIKGTTIKEGKMPEKAIYTLTDTGEKEFEKLMLDISSKPIHIFLDFNAVIV
                     NINNLSPDKQKKCLSDIKNNIEILKAYLEDNINSKEQKPEIPTAGMAVLQQQLILVQAI
                     ENWIATLPNVF"
     CDS             complement(5897..6223)
                     /locus_tag="ctg111_4"
                     /transl_table=11
                     /translation="MENEFTGFNCFMEESSEVGKAYIDMILQQEKASALDNKTRELAYI
                     AVLAATGIMGGLLYHVQSAKKLGASRDEVKSAILVGLPAVGLTIIDPLEAALKAFDGKS
                     DQIL"
     CDS             complement(6253..6414)
                     /gene_functions="biosynthetic-additional (lanthipeptides)
                     predicted lanthipeptide"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg111_5"
                     /transl_table=11
                     /translation="MKTCSERNEQRINSLQLSESLEDEIKELDGKNVEAGDVIFTTDTS
                     SFLTIVCC"
     CDS_motif       complement(6292..6414)
                     /prepeptide="leader"
                     /note="peptide class: {self.peptide_class}"
                     /note="predicted sequence:
                     MKTCSERNEQRINSLQLSESLEDEIKELDGKNVEAGDVIFT"
                     /locus_tag="ctg111_5_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       complement(6253..6291)
                     /prepeptide="core"
                     /locus_tag="ctg111_5_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class II"
                     /score="-4.00"
                     /molecular_weight="1199.4"
                     /monoisotopic_mass="1198.6"
                     /core_sequence="TDTSSFLTIVCC"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MKTCSERNEQRINSLQLSESLEDEIKELDGKNVEAGDVIFT
                     "
                     /leader_location="[6291:6414](-)"
                     /alternative_weights="1217.4"
                     /alternative_weights="1235.4"
                     /alternative_weights="1253.4"
     CDS             complement(6499..7800)
                     /locus_tag="ctg111_6"
                     /transl_table=11
                     /translation="MEEIYILNVLQYLLGYFEIYMCFEILRKVYKKENTKIKQCFEILI
                     CISLAVIEAINRSFRLYSILLIAVVIIVISITFSLIYKIKLRYTLLHTSLYCLSLELLD
                     LFIIFTMGIVLHKEDLGIIIGRQNSISRILALFLGRALMFLISLAIVRYKELIDKNRIG
                     SLVLILLSEIIGVIYFQSVYAGDSIPDLAKGYYMYFVIIILAIMFFAIYSIYRSALEES
                     KIIKLRNRMLERNYEDLKVYYNDSRTLFHDYRAHITLLQKYLEENQIDKACLYLNSINK
                     PLAELEKKIYTGNAVIDLVMNYKLSELKEKNIKIEYDIMPIDFGNYHFEESDIFVILYN
                     LFDNAIEACENIYTREKWIYLSLRLINNMFMLCIQNSYEIEPKYENGELLTIKTDKHFH
                     GIGMKSVKKIVEKYEGQLEYDNKQNIFEVSITLF"
     CDS             complement(7778..8629)
                     /locus_tag="ctg111_7"
                     /transl_table=11
                     /translation="MEYILFNRIALIRYVNYLVESLKSCSQKEKNKAEVINMPRIAIVD
                     DQEEYLEEICNLIEKFYFKNGIPYVVNTFSNAQLLLYEMEEKLYFDIYLLDIEMPGING
                     LSLAEKIRSMDDAGYIVFITSHLKFLINGYDYFAYQFIPKNNLKKKLISTLESLQKRLD
                     IEGEKFYQICTNHRYEKILYKDIYYVYKDEKYAIFVTQNGNIPIRETLKNIYKDLEQKE
                     FIFIDRGYIVNVVHIMSLYKNTIYLRNSKNLKISRTYTEEVKKRIHTYWKEHTTNGRDI
                     HT"
     CDS             8756..9103
                     /gene_functions="other (smcogs) SMCOG1148:hypothetical
                     protein (Score: 62; E-value: 1.5e-18)"
                     /gene_kind="other"
                     /locus_tag="ctg111_8"
                     /transl_table=11
                     /translation="MKDNNFVNLGKRIREKRLSQNLTQEALAEKADVGTTHISHIETGC
                     TKLSLTTFISIANALDVSADELLCDCINQASNVYETEISLLLKNCSTKEICFIHDLVKN
                     TLISLHNRNLK"
     CDS             complement(9151..10806)
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1059:acetyl-CoA carboxylase, carboxyl transferase,
                     (Score: 442; E-value: 5.3e-134)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg111_9"
                     /transl_table=11
                     /translation="MNDKDNRTDRNKENIPAVPPGMWIKCTKCGKLIYRKELEKNKFIC
                     MKCGKYFRMPSENRILDIIDEGSFVELFTDVLDKNPIDFPGYSEKKEIIKKETNLKEAV
                     ITGKASIGHIEVMLGVCDTRYLMGSMGYIVGEKITKLFENATKAQLPVIMINCSGGARM
                     QEGIISLMQMAKTVDSVKQHSDAGLLYISVLTDPTTGGVAASFAMLGDVILAEPNSLIG
                     FAGPRVIEQTTKQKLPVGFQTSEFLYEHGFLDMIVIRRELKERIYEILKAHQKPKVIER
                     KRKTISVCTFCDYKDSWKKVQLSRKIDRPTTVDYITHVFERFIEFHGDGETGEDQAIIG
                     GIAFLDNIPVTVIGHQKGKTTEERIIRNFGMAHPEGYRKAIHLMKEAEKFRRPIITFID
                     TPGAACGVEAEKRGEASAIAKCIYEMFNLKVPILSILIGEGGSGGALGLAVANEVWAME
                     NSTYSILSPEGFASILWKNEKRAKEAANLMKMTAKDLLDLGVIEKILPEGNGASEFKVI
                     TDFLQVQILDFIYNMSLKNEDEIVASRETRFRSF"
     CDS             complement(10834..12174)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ATP-grasp"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Dala_Dala_lig_C"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1090:acetyl-CoA carboxylase biotin carboxylase (Score:
                     605.8; E-value: 1.8e-183)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg111_10"
                     /sec_met_domain="ATP-grasp (E-value: 3.3e-08, bitscore:
                     24.1, seeds: 20, tool: rule-based-clusters)"
                     /sec_met_domain="Dala_Dala_lig_C (E-value: 4.6e-12,
                     bitscore: 36.6, seeds: 12, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MFEKILIANRGEIAVRIIKVCKEMGIKSVAIYSEADKDALHTKMA
                     DEAICIGPAPSGDSYLNMENIISAAVGTGAQAIHPGFGFLSENSLFAEKCKVCNITFIG
                     PTPEVICKMGNKVEARNMMRNAGVPIISGSRTPVFDVCEAKKVALELGFPIMIKAAAGG
                     GGKGMRISNTEDDFNENFVTAQMEANSSFRDGTMYLERYIEAPNHIEFQILADKYGNVI
                     QLGERDCSIQRHHQKIIEEAPSPKLSVKLRKEMGNIAIKVAKIVNYEGAGTVEFLLDKF
                     GKYYFIEMNTRIQVEHGITEMISNVDIVKEQIKIAAGYSLEFKQENILLQGHAIECRIN
                     AENPKMGFVPCPGKINNVYFPSGNGVRIDTALFNGCSVSPFYDSMLAKIIVYDSERKKA
                     IRKMKNVLKKIKIDGIITNLEFQNAILNHRDFEEGNFTTDFIVDKFS"
     CDS             complement(12186..12602)
                     /locus_tag="ctg111_11"
                     /transl_table=11
                     /translation="MKTEEVVHLLENVYKYNISELSIKSGDEKIIIKNGIDERAVDTVE
                     TVTERIEGESKNRIDEENIIKSPLVGRFYAAPAVGSDNYVKVGDKVEEGQTLAIIEAMK
                     LMNEIKSEYSGTIKSILVKNEELVEYGQPLFVLV"
     CDS             12803..13531
                     /NRPS_PKS="Domain: ACPS (129-186). E-value: 5.1e-07. Score:
                     21.4. Matches aSDomain: nrpspksdomains_ctg111_12_ACPS.1"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1012:4'-phosphopantetheinyl transferase (Score: 106.7;
                     E-value: 1.8e-32)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg111_12"
                     /transl_table=11
                     /translation="MLILHLKFFCSYGKLLIIILREDLLVLVLYLSTISLEWKNIDSDL
                     MQFVSKERRKKINQYFHVLDKKLSLYSALITRIGLSTISGLKHTELYFSYSQNHKPLFL
                     SKPKYDFSISHSNGSIISCISANSPVGADVEKISYPPFDIMDLIFSQPEIQYINNASDV
                     ERIFRFYKIWTQKEAYYKMLRIGLTGTATQCNSLNPDLSKLFYTWQEDHYMYCICGKNV
                     SERSLIKLSETEVQNYFIPI"
     aSDomain        13190..13360
                     /aSDomain="ACPS"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg111_12_ACPS.1"
                     /evalue="5.10E-07"
                     /label="ctg111_12_ACPS.1"
                     /locus_tag="ctg111_12"
                     /protein_end="186"
                     /protein_start="129"
                     /score="21.4"
                     /tool="antismash"
                     /translation="VGADVEKISYPPFDIMDLIFSQPEIQYINNASDVERIFRFYKIWT
                     QKEAYYKMLRIG"
     CDS             complement(13792..14271)
                     /locus_tag="ctg111_13"
                     /transl_table=11
                     /translation="MNENKKSAKRYHQFMITALKKKVNDMKDSAYSGLYSEIAFIIGIA
                     VIMIDTFFPPEETKANCVWKIILIAVSIVCMFYFAKKVKTVNEVEEEKKFWPNFFIQWA
                     TSLGYINMPVAMIAILVTFDKGKAWTLFMMGVAVILTGLTLIEALVKTSKIVKRL"
     CDS             complement(14331..14660)
                     /locus_tag="ctg111_14"
                     /transl_table=11
                     /translation="MKYVFPEYKENVVLGNGKLQLNPMSYQVIYEGKEIDLTPREFEVL
                     YLLALKPNWVMPKTNIYHSVWGIYYHDDQIPYRTVEYVIWKIRKKMGHDIIETLVNVGY
                     RLKKL"
ORIGIN
        1 ttgacaagta ttaattgttg aggtaattat ctcaaattac tataataatg tctatatatg
       61 cactatggtg cgcttacctt attgtgtcta taaaacactt tgcattgtca ctcttttatt
      121 gaatatttga tgactcgaaa tcatagatcc ggaaatttat aatcaaaatt ctaatactca
      181 aaaattgcct ttttgtactt aatcattaat acatttatat gagatgaata tccatgtctt
      241 atcatatctg cactatatag caaccttaag ccatttcttc atgaaaattt agaacgcaaa
      301 aaatgatcct caaacatgat ttttatatca ccagactggt gttgaaaaat cattcaggat
      361 actcatttat tctcgtagca aaaattaatg aaatttttta aagagaaagt attttactct
      421 attttgtata tggcatattt attatttgta caaaaaatta gcaggatata actatggaaa
      481 attatatcct gctaattttt attaattctc aattttttaa taataaggca tagtctatca
      541 ttattcttta tttttaatat atgaaagtct ttccttttcc aaacttttgt gtaaatttat
      601 ggccataaac actgtgataa ttgcagaaat aagatctgca attggctgtg catataagat
      661 accacttatt cctaccaaac tcggcaataa caagataatt ggtacaaaac aaatcccttg
      721 tctacaagct cccaaaataa atccttctaa acctttacct aaggcaagaa atagagaaga
      781 atacaccgta taaaatccaa aaagcataat agaaaatcca tttgctctga gtgaagcctg
      841 ccctattcta acaagttcca tatctcctgc tgtaaattta gaaataattg ttgcagggaa
      901 taaaattaat atcaatccaa aaagcgcaca aaacactgtt gaccacaaaa tagatgtttt
      961 aattgattca tttagacgtt taaaattttt cgctccataa ctgtatcctg caatcggttg
     1021 aaaaccttta ataaatccaa ataccattaa acttcccata gaaactattc ttgttacagc
     1081 tcccattccg gcaattactg aatctacata ttcttttgta tgtgttacac tcaaagcatt
     1141 ggcctgatta ttaattaaaa ttattgataa acttgtcaat aactggaata ccaatgttgg
     1201 tactcctatc ttcaaaattt ccttcatatt ttccttagaa taacaacaat ctttaatctt
     1261 aaatgtaaaa atactttttt tcataagaat atatgaaaga aaaacaactg ttgaaagagc
     1321 ctgtccaata gctgaagcaa tagcagctcc tgtaacgccc atatttaata cgtttataaa
     1381 aataggatct aaaatcatat ttaataatgc gcctgacaac attgcaaaca tagatatttt
     1441 agccgcacct tcacttgtta taatattatt catcatcaca ttgaaaatat taaaaataga
     1501 tgcagcaata aaaattcttg catatttaat cgcatatggc atgatacttt ctgttgtacc
     1561 aagaaacttc agaattggct caagaaaagc taacgtgcca attatgaaaa taattccaag
     1621 taaaagacca ctgtataagg ctgtactcgc aactttttta gcatcatcat tattcccacg
     1681 tcctagcagc ctagaaatat atgagcctgc gccattacca aacaatagtc ctaacccaac
     1741 aatcacctga cttaaaggat acgttactga aatcgcaccc atttggctcg ttcccaagcc
     1801 tccaacaaaa taggcatcta ccaaattgta aattgcgctg atcatcattc ctatcatagt
     1861 tggaattccc attgccaata acgcttttgg aatcggtgca ctccctaata attccatttt
     1921 tttgttatgt cctttcattt tttcactcct tttctaatac tataaattat agcgacatct
     1981 attataatac tataatttat agtagtagtc aagaaatttt ctaatttctt gaagagtttt
     2041 ttagagttct agttttaaaa tattaggaaa ttttttagaa ttttcatcta aatacagcac
     2101 tgcatatcca attcctgcca atcccatcat gaatcctgga ttaccatttt ctaaatttgt
     2161 ccacagattt ttttctataa aataatttaa tttactcaga gtgcttgtcc aaggtacaca
     2221 cggaattttt cctgttaatt gttgtataat cataatattt cctaaaatcc catgacataa
     2281 gcataaacta tccagttcta tattaaaatt attttctatc atgctaattt ttgtctgata
     2341 atcttcaaaa atatgctgat atgaaccatc ttcaatatat tttaatattt cttgctgcgc
     2401 caatactatt cctgctgccc catgacacca atatatcttt ctacttcttt gattctcttt
     2461 tttatttttt ataatatcat actttaatag ctccaatgca atgtttagat atttcctctt
     2521 ctttgtcttt ccaaataatc ttgtaaaaca aatactatat ccgctacctc catgtgcaat
     2581 ccccctatcc agccgagaaa ttttattacc ttcaatatta ttaaatatgc tatacgtttc
     2641 tttcaaattt ttcaaaatat aattcgccgc aatctcagca cgcaaaatat attttttatc
     2701 cattgttaat tcatacatat ttaaatatat tatgacagca ccggcattac catatagcaa
     2761 atctcccatc ctatcttttt ccaaactagc aaacaactta ttttcatgta tttttgcata
     2821 ttttatatat ttttcttcgt tgcttatctt atataatacc aaatatgtat aaataataga
     2881 tgcctcacca caaaatgcac ctgaatacgc ctttgaagaa gaattattca ttgtatattc
     2941 tagcaactta ttcaataaaa tattctgtac ttcaaaatat gctcttgttg gtgctacttc
     3001 atttaatgct gcaaaaaaaa ctatcatgcc agcaattcct tcatataaaa acatatctga
     3061 tatatgtatg gtaccagtca aggaaataat ccaattaata tctgttttta aactattctt
     3121 tatccctatt ttcataagat aatcagcaat ctgtttgcat attttaataa cggaaaaatt
     3181 tgtatcatgc atataatcca ttcgattttc caaatgaact gttgatcctt ttatagcgtt
     3241 atttaataaa tattgttgaa tatataaatc ctggctagat aatgatttaa tccgcatttt
     3301 aatatactgc tctggtgtaa tggtaaaata ttctttgatc atttgatgat tatccatata
     3361 caattctttt ttattcgata aaaaactaaa gtaaggaata tctcctttaa gcatagcata
     3421 tagctctgat tcaaataaat cttttccatt ttttggatta atttgtatat ggaagaagaa
     3481 attttttgaa aggattagct gtctttctcc tccatctgtc ataaacatag ggtgatatga
     3541 taattgaata agtttagaat agttttgagt atgattatac aacattctgg aactaaagtt
     3601 ttgaaatcgt ccctcaaaaa tcttattatt tttccagata tattcatagc ttttcctaaa
     3661 tcccagacaa atctcatcta caaatccatt atatctatat tctttatgat ttatctgtgg
     3721 actattatat cctttcttcg tttttgcatc tttgtataca aatttcatat ctgaagtttt
     3781 ggaatttatc aggagcaatc tttttctccc agttttcatt ccgccttttc cgcttaaagc
     3841 acaaaatata tccatctcct tatttcccct tggtaaaatc ccacttccta atactgaatt
     3901 ttctacaaat aattttgctt tctcgttagc ggtcaatgga atataatttt ttgtgatatg
     3961 tccacagagc acttcaatat ctataaacac aggatattcc ccatgagaaa tcaagttttc
     4021 ataatggaaa tcctgaatat ctaatatgta actcagtgca atatgacacc ccattctaat
     4081 ataataattt tttacttcat ctttattttt acatttttga tattttattt cttcttccca
     4141 accatactct ccaaaatctg ctattctata tttaaaacat gacaatccta catattcata
     4201 taatatattt aagcattcat aataaatttt tgatatcctc aaatttcttg gtttataaaa
     4261 tacagcattt ccgtttttca aaaaaatttt caccgtatgc tttccatttc tgtgattatc
     4321 ccctactttc ttaatttttg taatctcggt attatctata tttatacatt tttttatttc
     4381 tattacattt ttttcccatc tactgatcaa ttgatgataa aactctacga cactacaaat
     4441 tttctctaaa atgcatctta ataacagagg gtaaaactga aaaagctcct ctatatattc
     4501 atcattactt aaatacattt taacatatgt agaatatttt tcatttgcgt tctttcctac
     4561 caatttgttt tcaagaaact gtatttcatt aactaaaacc ctggttgcca cgcaagctaa
     4621 ggccaaatat aactcctcat aaattccttt agaaaaatat ttttctaaaa tatctccata
     4681 tttttttctt gaataatatc gggctagttt aaaaaatggt atataaaatg taaaaaacaa
     4741 tttatctttc attgtatttt ctataatgat ttcgctttta taactccctg ctaaatacat
     4801 ttctaaaatt tccatatact caacatttga gggagcttcc tgttcataat attgagtatt
     4861 ttcagaaaaa aaagaagaaa tctctttata ctctttgcaa agtatcttaa ctgtatcttc
     4921 tcctattaat ttttcccatt tagaaggaat ttttaactca ttatcttttc ttatatattt
     4981 tctttcaaat aaatagcgtt ctctcattta tattcaccca ataaatcatt tgttattttc
     5041 tatttgtatt gacaccgtaa aattatagta gtataattta taaccaaatc aacaactata
     5101 ctactataat atatagtata tgtcaaggat aggaggtcag catggcaacc attgatttaa
     5161 ttgtattagg tatgttaaag acatcagctt taagcgctta tgatattcaa aaacttgtag
     5221 aatatcgtaa tatatccaaa tgggtaaaaa ttagtacccc ttctatatat aaaaaagttc
     5281 ttcaattaga ggaaaaaggc cttataaaag gaactacgat taaagaagga aaaatgccag
     5341 aaaaggctat ttatacttta acagatacag gggagaaaga atttgagaag ttaatgcttg
     5401 atatttcttc taaaccaatt catatctttc tggattttaa tgcagtaata gtaaatataa
     5461 ataatctttc tcctgataag caaaaaaaat gcctttctga tataaaaaat aacattgaaa
     5521 tactgaaagc atatttagaa gataatatta attccaaaga gcaaaaacct gaaattccaa
     5581 ctgcaggtat ggccgttcta caacagcaac ttatattagt ccaagcaatt gaaaattgga
     5641 ttgccacttt accaaacgtc ttttaaaaac aaatattcca ggaagaaacc acaaaccttc
     5701 ccccatttgt cacttactta attttaagaa taatcctcaa ccttaccata tgttcttact
     5761 gtcccggatc cattttattg aataaccttc acagaaacaa gatgggcaat ttttcgtata
     5821 tcttaaaact tttaaaattc tatagaaaca aaagaagaag agctatcact atgtgatagg
     5881 ctcttcttct ttttaatcaa aggatttggt ctgattttcc gtcaaaggct ttaagagcgg
     5941 cttccaacgg atcaataatg gtcaatccga cagccggtaa tcccaccagt attgcactct
     6001 ttacctcatc acgacttgcg cctaactttt tagcagattg tacatgataa agcaaaccac
     6061 ccataattcc tgtagctgca agcactgcaa tatacgctaa ttcacgtgtt ttattatcca
     6121 atgcacttgc cttttcctgc tgcaaaatca tgtcaatata tgccttacct acttcgctac
     6181 tttcttccat aaaacaatta aaaccggtaa attcattttc catattaata tctcctttta
     6241 tttgaaaata ttttagcagc aaactattgt aagaaatgaa gatgtatctg tagtaaaaat
     6301 aacatctcct gcttctacat tctttccatc aagttccttt atttcgtctt ccaaactttc
     6361 tgataattgt aaactattta tccgctgctc atttctttct gaacatgttt tcattttttc
     6421 tcctcctttg attattaaaa taataccata tttttagatt ttgtcagtat tatgtcttaa
     6481 cttacaattt tttgaccttc agaaaagggt tatgctaact tcaaatatat tttgcttatt
     6541 atcatattct aactgtcctt catatttttc aacaattttc ttcacactct tcataccaat
     6601 tccatgaaaa tgtttatctg tttttatagt taaaagttct ccattttcgt atttaggctc
     6661 gatttcgtag ctgttttgta tacaaagcat aaacatatta ttaataagcc ttaatgataa
     6721 ataaatccat ttttctcttg tgtagatatt ttcacaagct tctatagcat tatcgaacaa
     6781 gttgtataaa ataacaaata tatcactttc ttcaaaatgg tagttgccaa aatcgattgg
     6841 cataatatca tattctattt taatattctt ttcttttagt tctgataatt tataattcat
     6901 taccagatca ataactgcat ttcctgtata aattttcttt tccaattccg caagtggttt
     6961 attaatacta ttgagatata aacaggcttt atctatttga ttttcttcca aatatttttg
     7021 cagcaaagta atatgggctc tataatcatg aaataaagtt cgagaatcat tataatatac
     7081 tttaagatct tcataattac gttccaacat tcgatttctc aatttaataa ttttactttc
     7141 ttccaacgca cttcgataaa tcgaatatat agcaaaaaac attatcgcta aaataatgat
     7201 aacgaaatac atataatatc cttttgctaa atcaggaata gaatcgcctg catacactga
     7261 ttgaaaatat ataactccga taatttccga taacaaaatc aacacgagtg atcctatgcg
     7321 gtttttatct ataagttctt tatacctcac tatggctaag gaaattagaa acattaaagc
     7381 tcttcccaaa aacaatgcca atattctgga tatactgttt tgtcttccta taataatccc
     7441 caaatcctct ttatgtaaca ctattcccat tgtgaatatg ataaatagat ctaataattc
     7501 taaactcaaa caatacaatg aggtatgaag caatgtatat cgtaatttga ttttataaat
     7561 caatgagaac gttatactta ttacgattat aacaacagca attaataaaa tagaatataa
     7621 tcgaaagcta cgattaatag cttctattac tgccaaactt atacaaatca atatttcaaa
     7681 acattgtttt atctttgtat tttccttttt ataaactttt cggagtatct caaaacacat
     7741 ataaatctca aaatatccta gtaaatattg gagtacatta agtatgtata tctcttccat
     7801 ttgttgtgtg ttccttccaa taagtgtgaa ttctcttttt tacctcttca gtatatgttc
     7861 tactaatttt aagattttta ctattacgca agtaaatagt atttttatat aaactcataa
     7921 tgtgtacgac attaacaatg tatcctctat ctataaaaat aaattctttt tgttctaaat
     7981 ctttataaat gttcttcaag gtttctcgta taggtatatt tccgttttgg gtaacaaaaa
     8041 tcgcatattt ttcatcttta tacacataat agatatcctt atataaaatt ttctcatatc
     8101 tatgattagt acatatttga taaaactttt ctccttcaat atccagcctt ttttgtaatg
     8161 attctaatgt cgatatcaac ttctttttca aattattttt agggataaac tgatatgcaa
     8221 aataatcata tccatttatt aaaaatttta aatgtgacgt gataaacaca atatatcctg
     8281 catcatccat agaacgtatt ttttcagcta aagatagtcc gtttatccca ggcatttcaa
     8341 tatctaatag ataaatatca aaatacaatt tttcttccat ttcgtatagt aacaactgtg
     8401 catttgaaaa agtattcaca acgtatggaa ttccattttt aaaataaaac ttctctatta
     8461 aattacaaat ttcttctaaa tactcttcct gatcatctac aattgctatt cttggcatat
     8521 ttatcacctc tgccttattt ttttctttct gtgaacatga ttttagcgat tctaccaaat
     8581 agtttacata tcttattagt gcaatccgat taaataatat atattccatg tgctttattt
     8641 catacactct ctaaacatct taaaactatc attatttagt ctatatgcac atataggtta
     8701 ttaagaaata ttttgattgc acatacaata cacatataat catggaggtg caattatgaa
     8761 agataacaat tttgtaaacc taggtaaacg tattcgtgaa aaacgcctat cccagaatct
     8821 tacccaagaa gctttagcag aaaaagcaga tgttggaaca acacacattt cgcatattga
     8881 aacaggctgt accaaactaa gtttaacaac ctttatttct attgcaaatg ctcttgatgt
     8941 atctgccgat gaattattat gtgactgcat taatcaagca tcaaatgtat atgaaacaga
     9001 aatttctcta cttttaaaaa actgttcaac taaagaaata tgctttatac atgacctagt
     9061 aaaaaataca cttatctctt tacataatcg caacttaaaa taatcaataa agactgaagt
     9121 ttttttcgct tcagtcttta tcaactctat ctaaaaactt ctaaatcttg tttctcttga
     9181 agccactatt tcatcttcat ttttaaggga catattatat ataaaatcaa gaatttgaac
     9241 ttgtagaaaa tctgtaatta ctttgaactc tgatgctcca ttcccttctg gtaatatttt
     9301 ctcaatcact cctaaatcta ataaatcttt tgccgtcatt ttcataaggt ttgctgcctc
     9361 ttttgcacgt ttttcatttt tccataaaat agaagcgaaa ccttctggag aaagtattga
     9421 atatgtagaa ttttccatag cccaaacctc atttgcaaca gctaaaccta aagctcctcc
     9481 actcccacct tcgcctataa gtatactcaa aatcggcact tttaaattga acatttcata
     9541 tatacatttt gctattgcag atgcttctcc tcttttttca gcctcaactc cacatgctgc
     9601 accaggtgta tctataaatg ttataattgg tcttctaaat ttctccgctt ctttcataag
     9661 atgaattgct tttctatatc cttcagggtg tgccattccg aaatttctaa taattctttc
     9721 ttctgtcgtt tttccctttt gatgtcctat aactgtaact ggaatattat ctaaaaaggc
     9781 tatacctcca attattgctt gatcctctcc ggtttcaccg tctccatgaa attctataaa
     9841 tctttcaaat acatgggtga tatagtctac tgtcgtcggt ctatctattt ttcttgataa
     9901 ttgtactttt ttccaactgt ccttataatc acaaaaagtg cacacagaaa ttgttttacg
     9961 ttttctttct ataacctttg gcttttggtg agctttaaga atttcataga tacgttcctt
    10021 taattctctt cttataacaa tcatatcaag gaatccatgt tcatataaaa attctgaggt
    10081 ttgaaatcct acaggcaact tctgttttgt agtttgttca attactcgtg gacccgcaaa
    10141 cccaattaat gaatttggtt cagccaatat cacatcacct aacatagcaa aactagctgc
    10201 caccccaccg gttgtcggat ctgtcaaaac tgatatatac aataaccccg catctgaatg
    10261 ttgttttacc gaatctactg tctttgccat ttgcatcaag gatatgatgc cttcttgcat
    10321 acgtgcgcct cctgaacaat taatcataat aactggtagc tgggctttgg ttgcattttc
    10381 gaataatttt gttattttct cgcctacaat ataccccata cttcccatca gatatcttgt
    10441 atcacataca ccaagcataa cctctatatg ccctattgac gcttttcctg taataacagc
    10501 ttcctttaaa ttagtttcct ttttaattat ctcttttttt tcactatatc ctggaaaatc
    10561 aattggattt ttatccaata catctgtaaa cagttcaaca aatgatcctt catctataat
    10621 atccaaaatt ctattttccg aaggcattct aaaatatttt ccacatttca tacaaataaa
    10681 tttatttttt tctaactctt ttctataaat caattttcca catttcgtac acttaatcca
    10741 cattccaggt ggtactgctg gtatattttc tttatttcta tctgttcgat tatctttgtc
    10801 attcataatg tcattcctct tatttcttta ttatcagcta aacttatcta caataaagtc
    10861 cgttgtaaaa ttcccttctt caaaatcgcg gtgatttaga atagcatttt gaaattctaa
    10921 attagttata attccgtcta tttttatttt ttttaaaaca tttttcattt ttctaatagc
    10981 cttttttcgt tctgaatcat acactataat ttttgcaagc atagaatcat aaaaaggtga
    11041 aacactacaa ccattaaata atgcagtatc aatgcgaaca ccattaccac ttggaaaata
    11101 aacattatta atttttccag gacatgggac aaaacccatc ttcggatttt ccgcattaat
    11161 tctacattcg atagcatgac cctgcaataa gatattttct tgcttaaact caagcgaata
    11221 gcctgctgca atttttatct gttccttaac aatgtcaaca ttagatatca tctctgtaat
    11281 tccatgttct acttgaatac gtgtattcat ttcaataaaa taatactttc cgaacttatc
    11341 aagcaagaat tctactgtac ctgcaccttc gtagtttaca atttttgcaa ctttgatcgc
    11401 tatatttccc atttcttttc ttaattttac cgatagtttt gggctaggag cttcttcaat
    11461 aattttctga tgatgccttt gaatagaaca atctctttct cccaactgta taacatttcc
    11521 atatttatct gcaagtattt gaaattctat atgatttggc gcttctatat acctttctaa
    11581 atacatcgtt ccatctctaa atgaactatt agcttccatc tgggctgtta caaagttttc
    11641 attaaaatca tcttctgtat tggatatcct catacctttt ccgccaccac ctgctgctgc
    11701 ctttatcata attggaaatc caagctctaa tgccactttt tttgcttcac acacatcaaa
    11761 aacgggagtc ctgcttcctg atataatcgg aactcccgca tttctcatca tattacgtgc
    11821 ttcaacttta tttcccattt tacaaatcac ttctggtgtt ggaccaatga atgtaatatt
    11881 acatactttg cacttttccg caaaaagact attttctgat aaaaatccaa aacctgggtg
    11941 aattgcctga gctcctgttc ctacagctgc actaataata ttttccatat tgagataact
    12001 atctcctgac ggtgcaggtc ctatacatat cgcctcatct gccatttttg tatgtaaagc
    12061 gtctttatct gcctctgaat atatagctac agacttaatt cccatctctt tacatacttt
    12121 tataattcgt acagctattt ctcctctatt agcaataagt attttttcaa acataaaaac
    12181 tcctttcaaa ctaaaacaaa taagggctgt ccatactcca ccagttcttc attttttact
    12241 aatatgcttt taatagttcc gctatattca ctcttaattt cattcattaa tttcattgct
    12301 tcgataatag caagtgtttg cccctcttct actttatctc ccactttaac ataattatca
    12361 cttccgacag caggggctgc ataaaaacgc cccaccaagg gtgattttat aatattttct
    12421 tcatcaattc tatttttact ttcaccctct attctttcag ttacagtttc cacagtatca
    12481 actgcccttt catcaatgcc atttttgatg ataatcttct catctccact ttttatacta
    12541 agctctgata tattatattt gtatacattt tctaataagt gtacaacttc ttctgttttc
    12601 attccttgcc tccatattac atgatgttat aaaaataaga ttattagata gaatattccc
    12661 ttttcttacg ctatctttta tacttttttt aacatagcat attttatatt cttatagacg
    12721 attttggatt tacttgcata tttttgtctt tattacacag aaatatcctt ataagatgct
    12781 cattttgcat tatccttata agatgctcat tttgcatttg aaatttttct gttcctatgg
    12841 taaactactc attattatac ttagggagga tttactcgtg ctagtgctgt atttatcaac
    12901 tatttcactc gaatggaaaa atatagattc tgatttaatg caatttgttt ccaaagaacg
    12961 aagaaagaaa ataaaccaat attttcatgt acttgacaaa aaactttctc tttattctgc
    13021 tcttattact cgtatcggat taagcactat atctggtttg aagcataccg aattatactt
    13081 ttcatattct caaaatcaca agccgctatt tttatctaag cctaaatatg acttcagtat
    13141 ttctcattca aatggttcta taatcagttg tatatcagct aattctccag ttggagccga
    13201 tgtagaaaaa atatcttatc caccatttga tattatggat ctcattttca gtcaaccgga
    13261 aattcaatac attaacaatg cctcagatgt tgaacgaatt tttagatttt acaaaatatg
    13321 gacgcaaaaa gaagcctatt ataaaatgct tagaatcggt cttactggta ctgcaaccca
    13381 atgcaactct ttaaatcctg atttatctaa attattttat acctggcaag aagaccatta
    13441 tatgtattgt atttgtggga aaaatgtatc tgaacgctcc ttaataaaat tgtcagaaac
    13501 ggaagtccaa aattatttta taccgatata aaaacagatt tacaggatat gtaaagattc
    13561 tatttcctgt aaatctgtct aacctttatt atgaactttt ttaaattctg tatcttcaat
    13621 tagtccctat agtaaaagca gctatgtcct cctcatatct gctctatttt tcctctatgt
    13681 gatacatctc atcgccaaac tccagttccc ttttattaca catacctgtt ctatggcatt
    13741 gtgaagatgc tgggaaacgt gatacaattt tttaatcaat tttattttct cttacaacct
    13801 ttttacaatt ttagaagttt ttacaagtgc ttctattaaa gttaaacctg tcaaaattac
    13861 agcaaccccc atcataaata atgtccatgc tttgccctta tcaaatgtta ccaaaatagc
    13921 tatcattgct acaggcatat ttatataccc taaacttgtt gcccattgaa taaaaaaatt
    13981 cggccaaaac tttttctctt cttccacttc attcactgtt ttcacttttt tagcgaaata
    14041 aaacatacag actatagata cagctatcag tattatcttc catacgcaat tagctttcgt
    14101 ttcctctggt ggaaaaaagg tatctatcat gataactgct attccaatga taaacgctat
    14161 ttcactatac aatcctgaat aagcggaatc tttcatgtca tttacttttt tctttaaagc
    14221 agtaatcata aattggtggt accgtttcgc acttttctta ttttcattca tatcatatat
    14281 cctccattcg taataacata ccgtttcatc tcaattatat ctccaggaaa ctacagcttt
    14341 ttcaaccgat accccacatt gaccaatgtt tcgataatat catgtcccat cttttttctt
    14401 atcttccata tcacatattc tactgttcta tatggtatct gatcgtcatg ataataaatc
    14461 ccccatacag aatgataaat atttgtcttt ggcattaccc agtttggctt taaagccagt
    14521 aggtataaaa cttcaaattc cctgggtgtc aggtctatct cctttccttc gtagataacc
    14581 tgataggaca ttggatttaa ctgtaatttc ccattgccca acactacatt ctctttatat
    14641 tctggaaaaa catacttcat gtgtatgcct cctcttgatt tgtaaattca acttttctca
    14701 ttccagaaag aaatactgga cgaaaacttc ccgcccagca cttcttcaat tatcagttat
    14761 tttaatgtac tctctatatc ctccgctgcc ttttctataa tttgaagata ctcctggagc
    14821 ttttcagatt ggatatttcc cttttctgca agtgaattga ttagaaaaca acttgctttt
    14881 atgcagctta gcggatttcg gatattgctc tgcaattgtg cccgcatagt gcgataatca
    14941 ttgtctatat tcagtgtcct tgtcgctgcc ttttcgcaaa ggtccagtaa tggattgatg
    15001 tactctg
//
