GCA_009881295.1 - 6 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

gnlProkkaBOONPHDL_17 (original name was: gnl|Prokka|BOONPHDL_17)

Region	Type	From	To	Most similar known cluster		Similarity
Region 17.1	lanthipeptide-class-ii	107	22,737

gnlProkkaBOONPHDL_19 (original name was: gnl|Prokka|BOONPHDL_19)

Region	Type	From	To	Most similar known cluster		Similarity
Region 19.1	lanthipeptide-class-ii,cyclic-lactone-autoinducer	2,738	38,098	ruminococcin A	RiPP:Lanthipeptide	21%

gnlProkkaBOONPHDL_25 (original name was: gnl|Prokka|BOONPHDL_25)

Region	Type	From	To	Most similar known cluster		Similarity
Region 25.1	NRPS	18,510	57,505	dipeptide aldehydes	NRP	47%

gnlProkkaBOONPHDL_64 (original name was: gnl|Prokka|BOONPHDL_64)

Region	Type	From	To	Most similar known cluster		Similarity
Region 64.1	ranthipeptide	38,042	59,630

gnlProkkaBOONPHDL_71 (original name was: gnl|Prokka|BOONPHDL_71)

Region	Type	From	To	Most similar known cluster		Similarity
Region 71.1	cyclic-lactone-autoinducer	1	7,942

gnlProkkaBOONPHDL_108 (original name was: gnl|Prokka|BOONPHDL_108)

Region	Type	From	To	Most similar known cluster		Similarity
Region 108.1	ranthipeptide	8,413	31,028

Region	Type	From	To	Most similar known cluster	Similarity
Region 17.1	lanthipeptide-class-ii	107	22,737
Region 19.1	lanthipeptide-class-ii,cyclic-lactone-autoinducer	2,738	38,098	ruminococcin A	RiPP:Lanthipeptide	21%
Region 25.1	NRPS	18,510	57,505	dipeptide aldehydes	NRP	47%
Region 64.1	ranthipeptide	38,042	59,630
Region 71.1	cyclic-lactone-autoinducer	1	7,942
Region 108.1	ranthipeptide	8,413	31,028

Compact view

gnlProkkaBOONPHDL_17 - Region 1 - lanthipeptide-class-ii

Download region GenBank file

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Location: 107 - 22,737 nt. (total: 22,631 nt) Show pHMM detection rules used

Region on contig edge.

lanthipeptide-class-ii: cds(LANC_like and DUF4135)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

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Gene details

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Gene overview

KnownClusterBlast

Lanthipeptides

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Similar known gene clusters from MIBiG 3.1

No matches found.

Lanthipeptide predictions

Lanthipeptide(s) for ctg17_10

allorf_01564_01749

Leader:

MSLNFSTYAYITKSPVRYSDAAVFSA

Core:

AAPDYHHPELFPVLLLFHTRELYPHMTEVTCFQTL

Core with dehydrations:

AAPDYHHPELFPVLLLFHDhbRELYPHMDhbEVDhbCysFQDhbL

antiSMASH-DB 4.0 matches for allorf_01564_01749

14.3% NZ_CP058552.1: Lanthipeptides: allorf_1481579_1481740_lanthipeptide

23

YPHMTEVTCFQTL

35

Y H+ + C QT+

6

YKHVQKTNCVQTI

18

allorf_16620_16748

Leader:

MLQLLTILLTPIYFRMHLQAG

Core:

QILTCLVVLMVIFIVTHYTCN

Core with dehydrations:

QILDhbCysLVVLMVIFIVDhbHYDhbCysN

Legend:

Dha: Didehydroalanine
Dhb: Didehydrobutyrine

Lanthipeptides

Core peptide predictions

allorf_01564_01749 - Class II

Cleavage pHMM score: -6.80

RODEO score: 0

Monoisotopic mass: 4093.1 Da

Molecular weight: 4095.7 Da

Number of bridges: 1

Alternative weights: (assuming N unmodified Ser/Thr residues); 4113.7 Da N = 1; 4131.7 Da N = 2; 4149.7 Da N = 3

allorf_16620_16748 - Class II

Cleavage pHMM score: -4.90

RODEO score: 0

Monoisotopic mass: 2368.3 Da

Molecular weight: 2369.9 Da

Number of bridges: 2

Alternative weights: (assuming N unmodified Ser/Thr residues); 2388.0 Da N = 1

gnlProkkaBOONPHDL_19 - Region 1 - cyclic-lactone-autoinducer,lanthipeptide-class-ii

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Location: 2,738 - 38,098 nt. (total: 35,361 nt) Show pHMM detection rules used

Region on contig edge.

lanthipeptide-class-ii: cds(LANC_like and DUF4135)
cyclic-lactone-autoinducer: (TIGR04223 or AgrB)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

KnownClusterBlast

Lanthipeptides

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Similar known gene clusters from MIBiG 3.1

Lanthipeptide predictions

Lanthipeptide(s) for ctg19_16

ctg19_15

Leader:

MSEMRNPITREENFS

Core:

NPAGNVMMELQEADLNKFVAGAGETRNSGGVLCTSTAECYFGTLLKPCCPKK

Core with dehydrations:

NPAGNVMMELQEADLNKFVAGAGEDhbRNDhaGGVLCysDhbDhaDhbAECysYFGDhbLLKPCysCysPKK

MIBiG 3.1 matches for ctg19_15

15.4% BGC0002110 (QKV49893.1): Lanthipeptide: birimositide

27

NSGGVLCTSTAEC

39

N+GG CT T EC

14

NNGG-WCTLTKEC

25

11.5% BGC0000517 (BAB04173.1): Lanthipeptide: haloduracin β or haloduracin α

30

GVLCTSTAEC

39

G CT T EC

14

GAYCTLTVEC

23

7.7% BGC0001229 (SBI_06990): Lanthipeptide: SBI-06990 A1 or SBI-06989 A2

33

CTSTAEC

39

CT + EC

28

CTLSKEC

34

antiSMASH-DB 4.0 matches for ctg19_15

100.0% NZ_CZAY01000009.1and 12 others:

NZ_CZBA01000009.1 Lanthipeptides: ARA06_RS08755_lanthipeptideNZ_CZBB01000003.1 Lanthipeptides: ARA29_RS04330_lanthipeptideNZ_JADPDU010000003.1 Lanthipeptides: I4V06_RS02990_lanthipeptideNZ_JAOQJU010000001.1 Lanthipeptides: OCV99_RS00835_lanthipeptideNZ_JAQCSY010000025.1 Lanthipeptides: PGZ10_RS13865_lanthipeptideNZ_JAQEDC010000020.1 Lanthipeptides: PHA23_RS12680_lanthipeptideNZ_QRZZ01000001.1 Lanthipeptides: DWV87_RS01465_lanthipeptideNZ_QSUB01000001.1 Lanthipeptides: DXB81_RS03120_lanthipeptideNZ_QUCI01000019.1 Lanthipeptides: DW648_RS14740_lanthipeptideNZ_QULD01000003.1 Lanthipeptides: DXB83_RS07060_lanthipeptideNZ_QULI01000007.1 Lanthipeptides: DXB71_RS08970_lanthipeptideNZ_SLZV01000043.1 Lanthipeptides: EDD74_RS14380_lanthipeptide

Lanthipeptides: ARA07_RS06830_lanthipeptide

1

NPAGNVMMELQEADLNKFVAGAGETRNSGGVLCTSTAECYFGTLLKPCCPKK

52

NPAGNVMMELQEADLNKFVAGAGETRNSGGVLCTSTAECYFGTLLKPCCPKK

1

NPAGNVMMELQEADLNKFVAGAGETRNSGGVLCTSTAECYFGTLLKPCCPKK

52

36.5% NZ_QRHZ01000008.1and 2 others:

NZ_QSRF01000021.1 Lanthipeptides: DXC87_RS15310_lanthipeptideNZ_QUEQ01000033.1 Lanthipeptides: DXA48_RS19000_lanthipeptide

Lanthipeptides: DW272_RS13830_lanthipeptide

22

AGETRNSGGVLCTSTAECYFGTLLKPCC

49

AGE RNSGG+ CTST EC GTL CC

1

AGEPRNSGGMFCTSTGECNMGTLNIFCC

28

32.7% NZ_CYXV01000003.1: Lanthipeptides: ARB75_RS04585_lanthipeptide

22

AGETRNSGGVLCTSTAECYFGTLLKPCC

49

AG RNSGG+ CT T EC GT +K CC

1

AGVARNSGGIACTLTGECNIGTHIKFCC

28

with 44 more sequence matches

25.0% NZ_CP071875.1: Lanthipeptides: J4I02_RS02880_lanthipeptide

23

GETRNSGGVLCTSTAECYFGTLLKPCC

49

G +SGG +CT T EC GT CC

2

GIPNHSGGAICTLTHEC-AGTHWYSCC

27

21.2% NC_009480.1and 10 others:

NZ_CP033724.1 Lanthipeptides: EFE39_RS10220_lanthipeptideNZ_CP047051.1 Lanthipeptides: GRD74_RS10365_lanthipeptideNZ_CP047054.1 Lanthipeptides: GRD61_RS10460_lanthipeptideNZ_CP053860.1 Lanthipeptides: DQP62_RS10825_lanthipeptideNZ_CP076352.1 Lanthipeptides: KN218_RS09900_lanthipeptideNZ_CP085137.1 Lanthipeptides: LHJ48_RS10290_lanthipeptideNZ_CP085140.1 Lanthipeptides: LHJ47_RS10305_lanthipeptideNZ_CP095274.1 Lanthipeptides: MU580_RS10460_lanthipeptideNZ_PSTW01000024.1 Lanthipeptides: C5C03_RS09675_lanthipeptideNZ_SISU01000002.1 Lanthipeptides: EOG37_RS09890_lanthipeptide

Lanthipeptides: CMM_RS10575_lanthipeptide

27

NSGGVLCTSTAECYFGTLLKPC

48

+S G LCT T EC GT++ C

1

SSSGWLCTLTIEC--GTIICAC

20

21.2% NZ_CP036455.1and 1 other:

NZ_JAODUN010000003.1 Lanthipeptides: BXY51_RS10560_lanthipeptide

Lanthipeptides: EKD16_RS25235_lanthipeptide

28

SGGVLCTSTAECYFGTLLKPC

48

S G +CT T EC GTL+ C

1

SSGWVCTLTIEC--GTLVCAC

19

21.2% NZ_CP045267.1and 1 other:

NZ_CP045267.1 Lanthipeptides: FDZ14_RS00155_lanthipeptide

Lanthipeptides: FDZ14_RS00155_lanthipeptide

30

GVLCTSTAECYFGTLLKPCCPKK

52

GV+ T+T+ECY GT CC +

3

GVVKTATSECYLGTFAFACCLAR

25

21.2% NZ_CP061274.1and 1 other:

NZ_JADKRR010000001.1 Lanthipeptides: ITJ40_RS10085_lanthipeptide

Lanthipeptides: H9X71_RS09850_lanthipeptide

28

SGGVLCTSTAECYFGTLLKPC

48

S G LCT T EC GT + C

2

SSGWLCTLTIEC--GTFICAC

20

21.2% NZ_CP117876.1: Lanthipeptides: PQ460_RS01735_lanthipeptide

30

GVLCTSTAECYFGTLLKPCCPKK

52

GV+ T+T+ECY GT+ CC +

3

GVVKTATSECYLGTVAFICCLGR

25

21.2% NZ_FQZK01000006.1and 2 others:

NZ_FQZK01000006.1 Lanthipeptides: BUE45_RS13060_lanthipeptideNZ_FQZK01000006.1 Lanthipeptides: BUE45_RS13060_lanthipeptide

Lanthipeptides: BUE45_RS13060_lanthipeptide

16

NKFVAGAGETRNSGGVLCTSTAEC

39

N +A A +RN+ G CT T EC

11

NPLIACALLSRNNTGRFCTVTVEC

34

21.2% NZ_JAFCGV010000005.1: Lanthipeptides: JQI09_RS04275_lanthipeptide

30

GVLCTSTAECYFGTLLKPCCPKK

52

GV+ T+T+ECY GT CC +

3

GVVKTATSECYLGTFAFVCCLAR

25

21.2% NZ_NTSR01000029.1and 1 other:

NZ_NTSR01000029.1 Lanthipeptides: CN358_RS25180_lanthipeptide

Lanthipeptides: CN358_RS25180_lanthipeptide

9

ELQEADLNKFVAGAGETRNSGGVLCTSTAEC

39

AD K G G G +CT T EC

10

SFNSADYIKLSIGLGNN----GYICTYTVEC

36

19.2% NZ_AUBN01000022.1: Lanthipeptides: G448_RS16025_lanthipeptide

28

SGGVLCTSTAECYFGTLLKPC

48

S G CT T EC GT + C

2

SSGWFCTLTIEC--GTFICAC

20

19.2% NZ_CAKMMP010000011.1: Lanthipeptides: L6H98_RS19925_lanthipeptide

21

GAGETRNSGGVLCTSTAECYFGTL

44

A E SGGV CT + EC++ ++

2

AAIEAAKSGGVFCTVSHECHYNSV

25

19.2% NZ_CP016767.1: Lanthipeptides: BCV50_RS18735_lanthipeptide

27

NSGGVLCTSTAECYFGTL

44

N+ G CT +AEC FGT+

17

NNYGQYCTVSAEC-FGTI

33

19.2% NZ_CP028130.1: Lanthipeptides: C7V51_RS14690_lanthipeptide

28

SGGVLCTSTAECYFGTLLKPC

48

S G +CT T EC GT++ C

2

SSGWMCTLTIEC--GTIICAC

20

19.2% NZ_CP083176.1and 4 others:

NZ_JABUHD010000002.1 Lanthipeptides: HRR08_RS05415_lanthipeptideNZ_LSLF01000001.1 Lanthipeptides: AXE72_RS04025_lanthipeptideNZ_PNHB01000001.1 Lanthipeptides: CJ210_RS02800_lanthipeptideNZ_QJVA01000001.1 Lanthipeptides: D0T19_RS02755_lanthipeptide

Lanthipeptides: K9E37_RS06280_lanthipeptide

30

GVLCTSTAECYFGT--LLKPCC

49

GV+ T T EC+ T L CC

3

GVMHTLTHECHMNTWQFLLTCC

24

19.2% NZ_CP102267.1and 11 others:

NZ_FMUW01000051.1 Lanthipeptides: BLP57_RS16830_lanthipeptideNZ_JAQDBP010000004.1 Lanthipeptides: PGY07_RS07130_lanthipeptideNZ_JAQEHQ010000024.1 Lanthipeptides: PGR68_RS13915_lanthipeptideNZ_JAQESL010000043.1 Lanthipeptides: PG840_RS15980_lanthipeptideNZ_JAQESS010000001.1 Lanthipeptides: PG808_RS00050_lanthipeptideNZ_LN913006.1 Lanthipeptides: BN3261_RS01470_lanthipeptideNZ_QRPQ01000011.1 Lanthipeptides: DWZ74_RS14610_lanthipeptideNZ_QRZZ01000003.1 Lanthipeptides: DWV87_RS03120_lanthipeptideNZ_QSJW01000012.1 Lanthipeptides: DW767_RS16305_lanthipeptideNZ_QSKF01000004.1 Lanthipeptides: DW740_RS06255_lanthipeptideNZ_QUJJ01000004.1 Lanthipeptides: DW748_RS03580_lanthipeptide

Lanthipeptides: NQ550_RS04155_lanthipeptide

32

LCTSTAECYFGTLLKPCC

49

CTST EC +GT++ CC

2

FCTSTKECNWGTIMFVCC

19

19.2% NZ_FMVM01000006.1and 2 others:

NZ_RIAS01000010.1 Lanthipeptides: EC604_RS18225_lanthipeptideNZ_VEJI01000010.1 Lanthipeptides: FS576_RS22075_lanthipeptide

Lanthipeptides: BLQ13_RS10365_lanthipeptide

21

GAGETRNSGGVLCTSTAECYFGTL

44

A E + SGGV CT + EC++ ++

2

AAIEDKKSGGVFCTVSHECHYNSV

25

19.2% NZ_GG666304.1: Lanthipeptides: HMPREF0077_RS09155_lanthipeptide

26

RNSGGVLCTSTAECYFGTLL

45

++S G CT T EC F TL+

13

KDSCGHGCTITTECPFATLI

32

19.2% NZ_JAESIP010000017.1and 3 others:

NZ_LT907978.1 Lanthipeptides: EHLA_RS12685_lanthipeptideNZ_QRYY01000029.1 Lanthipeptides: DWW21_RS18370_lanthipeptideNZ_SPFW01000044.1 Lanthipeptides: FGQ81_RS16590_lanthipeptide

Lanthipeptides: JMK14_RS12260_lanthipeptide

28

SGGVLCTSTAECYFGTLL

45

S G LCT TAEC T++

15

SCGRLCTGTAECPIMTII

32

19.2% NZ_JALAMD010000003.1and 1 other:

NZ_JALAMZ010000007.1 Lanthipeptides: MOC43_RS14030_lanthipeptide

Lanthipeptides: MOB22_RS05100_lanthipeptide

27

NSGGVLCTSTAECYFGTL

44

N+ G CT +AEC FGT+

17

NNYGKYCTVSAEC-FGTI

33

17.3% NZ_ALVU02000002.1and 1 other:

NZ_ALVU02000002.1 Lanthipeptides: SYN7509_RS28800_lanthipeptide

Lanthipeptides: SYN7509_RS28800_lanthipeptide

16

NKFVAGAGETRNSGGVLCT

34

KF G E+ NSG + CT

1

RKFTYGGDESCNSGIIACT

19

17.3% NZ_BMRY01000003.1and 28 others:

NZ_BMRY01000003.1 Lanthipeptides: IE140_RS12370_lanthipeptideNZ_BMSZ01000006.1 Lanthipeptides: IE135_RS12780_lanthipeptideNZ_BMSZ01000006.1 Lanthipeptides: IE135_RS12780_lanthipeptideNZ_BNBJ01000003.1 Lanthipeptides: IE304_RS05285_lanthipeptideNZ_BNBJ01000003.1 Lanthipeptides: IE304_RS05285_lanthipeptideNZ_CP021707.1 Lanthipeptides: CCZ36_RS18205_lanthipeptideNZ_CP079114.1 Lanthipeptides: KV381_RS19425_lanthipeptideNZ_CP079114.1 Lanthipeptides: KV381_RS19425_lanthipeptideNZ_CP084357.1 Lanthipeptides: LEL86_RS34965_lanthipeptideNZ_CP084357.1 Lanthipeptides: LEL86_RS34965_lanthipeptideNZ_CP116355.1 Lanthipeptides: KPP03845_RS17815_lanthipeptideNZ_CP116355.1 Lanthipeptides: KPP03845_RS17815_lanthipeptideNZ_JALDPQ010000054.1 Lanthipeptides: MQC87_RS11020_lanthipeptideNZ_JALDPQ010000054.1 Lanthipeptides: MQC87_RS11020_lanthipeptideNZ_JAMFLF010000021.1 Lanthipeptides: M1212_RS32880_lanthipeptideNZ_JAMFLF010000021.1 Lanthipeptides: M1212_RS32880_lanthipeptideNZ_JNLT01000014.1 Lanthipeptides: CD02_RS38630_lanthipeptideNZ_JNLT01000014.1 Lanthipeptides: CD02_RS38630_lanthipeptideNZ_JNZV01000231.1 Lanthipeptides: BG84_RS0100145_lanthipeptideNZ_JNZV01000231.1 Lanthipeptides: BG84_RS0100145_lanthipeptideNZ_KZ819178.1 Lanthipeptides: DBP20_RS18455_lanthipeptideNZ_KZ819178.1 Lanthipeptides: DBP20_RS18455_lanthipeptideNZ_LZRD01000017.1 Lanthipeptides: A3Q37_RS19720_lanthipeptideNZ_LZRD01000017.1 Lanthipeptides: A3Q37_RS19720_lanthipeptideNZ_NNBN01000001.1 Lanthipeptides: CG717_RS03735_lanthipeptideNZ_NNBN01000001.1 Lanthipeptides: CG717_RS03735_lanthipeptideNZ_WHOM01000078.1 Lanthipeptides: GCN81_RS29300_lanthipeptideNZ_WHOM01000078.1 Lanthipeptides: GCN81_RS29300_lanthipeptide

Lanthipeptides: IE140_RS12370_lanthipeptide

21

GAGETRNSGGVLCTSTAEC

39

GA + G CT+TAEC

15

GASYVLGNNGNFCTATAEC

33

17.3% NZ_CP034669.1: Lanthipeptides: EJ065_RS32040_lanthipeptide

26

RNSGGVLCTSTAEC

39

RNS G +CT T EC

7

RNSCGYVCTLTTEC

20

17.3% NZ_CP040409.1and 4 others:

NZ_CP040411.1 Lanthipeptides: FE334_RS06825_lanthipeptideNZ_CP040422.1 Lanthipeptides: FE323_RS09430_lanthipeptideNZ_JH601103.1 Lanthipeptides: HMPREF9703_RS02710_lanthipeptideNZ_NAQX01000046.1 Lanthipeptides: B8A46_RS06295_lanthipeptide

Lanthipeptides: FE336_RS08590_lanthipeptide

26

RNSGGVLCTSTAEC

39

R+S G CT TAEC

12

RHSCGRACTITAEC

25

17.3% NZ_CP086242.1and 1 other:

NZ_CP086245.1 Lanthipeptides: LL037_RS25615_lanthipeptide

Lanthipeptides: LL038_RS25355_lanthipeptide

28

SGGVLCTSTAEC-YFGTL

44

S G +CT+T EC YF +

2

SSGAICTATTECTYFSAI

19

17.3% NZ_CP092836.1: Lanthipeptides: MLD62_RS30280_lanthipeptide

14

DLNKFVAGAGETRNSGGVLCTSTAEC

39

+L+ +A A + + G CT +AEC

2

NLSAAIADAAGLKGNYGKFCTYSAEC

27

17.3% NZ_JAENHX010000011.1: Lanthipeptides: JIN86_RS20375_lanthipeptide

15

LNKFVAGAGETRNSGGVLCTSTAEC

39

+++ +A A N+ G+ CT +AEC

7

ISRAIANAVGLGNNYGMACTWSAEC

31

17.3% NZ_QORY01000016.1and 1 other:

NZ_QORY01000016.1 Lanthipeptides: DT250_RS18255_lanthipeptide

Lanthipeptides: DT250_RS18255_lanthipeptide

30

GVLCTSTAECYFGTLLKP

47

G +CT T EC G L P

23

GRICTYTLECTAGCNLNP

40

16.4% NZ_AP023359.1: Lanthipeptides: Prubr_RS34925_lanthipeptide

1

NPAGNVMM--ELQEADLNKFVAGAGET

25

NPAG + + + EAD+ +G G T

13

NPAGPLFLGGKYAEADITATGSGGGAT

39

15.4% NZ_CP018620.1and 1 other:

NZ_CP062165.1 Lanthipeptides: JNUCC31_RS16755_lanthipeptide

Lanthipeptides: BS614_RS05680_lanthipeptide

24

ETRNSGGVLCTSTAECYFGTL

44

+ + SGGV CT + EC++ ++

5

DAQASGGVFCTVSHECHYNSV

25

15.4% NZ_CP022163.1: Lanthipeptides: MEBOL_RS24465_lanthipeptide

27

NSGGVLCTSTAEC

39

NSGG +CT + EC

10

NSGGWICTYSTEC

22

15.4% NZ_CP030280.1and 5 others:

NZ_CP030280.1 Lanthipeptides: DQQ01_RS07655_lanthipeptideNZ_CP030280.1 Lanthipeptides: DQQ01_RS07650_lanthipeptideNZ_CP030280.1 Lanthipeptides: DQQ01_RS07645_lanthipeptideNZ_CP030280.1 Lanthipeptides: DQQ01_RS07650_lanthipeptideNZ_CP030280.1 Lanthipeptides: DQQ01_RS07645_lanthipeptide

Lanthipeptides: DQQ01_RS07655_lanthipeptide

23

GETRNSG--GVLCTSTAEC

39

G++++ G G LC+ T EC

1

GKSKDWGNDGYLCSVTVEC

19

15.4% NZ_CP034248.1: Lanthipeptides: EIM92_RS14995_lanthipeptide

28

SGGVLCTSTAECYFGTL

44

SGGV+CT + EC++ ++

6

SGGVICTISHECHYNSV

22

15.4% NZ_CP086142.1and 3 others:

NZ_CP086142.1 Lanthipeptides: LL065_RS25460_lanthipeptideNZ_CP086142.1 Lanthipeptides: LL065_RS25455_lanthipeptideNZ_CP086142.1 Lanthipeptides: LL065_RS25450_lanthipeptide

Lanthipeptides: LL065_RS25465_lanthipeptide

29

GGVLCTSTAECYFGTL

44

GGV+ T T ECY+ ++

2

GGVITTFTHECYYNSV

17

15.4% NZ_CP091285.1: Lanthipeptides: L2Z92_RS16370_lanthipeptide

23

GETRNSGGVLCTSTAEC

39

G+TR + G C +TA C

1

GKTRTASGSTCDNTAVC

17

15.4% NZ_CP114875.1: Lanthipeptides: O4Z47_RS14375_lanthipeptide

26

RNSGGVLCTSTAEC

39

+NS G +CT T+EC

5

KNSSGDICTLTSEC

18

15.4% NZ_CP115450.1and 1 other:

NZ_CP115450.1 Lanthipeptides: O1G21_RS35415_lanthipeptide

Lanthipeptides: O1G21_RS35415_lanthipeptide

30

GVLCTSTAEC

39

G LCT TAEC

22

GYLCTVTAEC

31

15.4% NZ_JADPCZ010000011.1and 1 other:

NZ_OW659477.1 Lanthipeptides: NMG62_RS06660_lanthipeptide

Lanthipeptides: I4W03_RS06785_lanthipeptide

26

RNSGGVLCTSTAECYFGTLL

45

++S G CT T EC T++

13

KHSCGRACTVTTECPIATII

32

15.4% NZ_JALMDK010000017.1: Lanthipeptides: allorf_059288_059443_lanthipeptide

28

SGGVLCTSTAEC

39

SGG +CT T EC

2

SGGYICTLTWEC

13

13.5% NZ_BCEY01000006.1and 1 other:

NZ_BCEY01000006.1 Lanthipeptides: GOZ53_RS01290_lanthipeptide

Lanthipeptides: GOZ53_RS01290_lanthipeptide

30

GVLCTSTAEC

39

G +CT TAEC

23

GWICTWTAEC

32

13.5% NZ_CP077726.1and 12 others:

NZ_CP077726.1 Lanthipeptides: KTC92_RS18420_lanthipeptideNZ_CP077726.1 Lanthipeptides: KTC92_RS18415_lanthipeptideNZ_CP077726.1 Lanthipeptides: KTC92_RS18410_lanthipeptideNZ_CP077726.1 Lanthipeptides: KTC92_RS18405_lanthipeptideNZ_CP086248.1 Lanthipeptides: LL036_RS19070_lanthipeptideNZ_CP086248.1 Lanthipeptides: LL036_RS19065_lanthipeptideNZ_CP086248.1 Lanthipeptides: LL036_RS19060_lanthipeptideNZ_CP086248.1 Lanthipeptides: LL036_RS19055_lanthipeptideNZ_CP086248.1 Lanthipeptides: LL036_RS19050_lanthipeptideNZ_CP086248.1 Lanthipeptides: LL036_RS19045_lanthipeptideNZ_CP086248.1 Lanthipeptides: LL036_RS19040_lanthipeptideNZ_CP086248.1 Lanthipeptides: LL036_RS19035_lanthipeptide

Lanthipeptides: KTC92_RS18425_lanthipeptide

30

GVLCTSTAECYFGTL

44

GV+ T T ECY+ ++

3

GVITTFTHECYYNSV

17

13.5% NZ_JAQDBP010000004.1and 18 others:

NZ_JAQDBP010000004.1 Lanthipeptides: PGY07_RS07085_lanthipeptideNZ_JAQEAL010000002.1 Lanthipeptides: PGU65_RS02165_lanthipeptideNZ_JAQESL010000010.1 Lanthipeptides: PG840_RS09145_lanthipeptideNZ_JAQEUC010000007.1 Lanthipeptides: PG788_RS06860_lanthipeptideNZ_QRHW01000005.1 Lanthipeptides: DW641_RS05035_lanthipeptideNZ_QROS01000011.1 Lanthipeptides: DW021_RS13630_lanthipeptideNZ_QRPQ01000001.1 Lanthipeptides: DWZ74_RS02490_lanthipeptideNZ_QRZZ01000003.1 Lanthipeptides: DWV87_RS03165_lanthipeptideNZ_QRZZ01000003.1 Lanthipeptides: DWV87_RS03165_lanthipeptideNZ_QSJW01000012.1 Lanthipeptides: DW767_RS16350_lanthipeptideNZ_QSJW01000012.1 Lanthipeptides: DW767_RS16350_lanthipeptideNZ_QSKF01000004.1 Lanthipeptides: DW740_RS06305_lanthipeptideNZ_QSKF01000004.1 Lanthipeptides: DW740_RS06305_lanthipeptideNZ_QTZB01000014.1 Lanthipeptides: DXC15_RS13895_lanthipeptideNZ_QUCI01000011.1 Lanthipeptides: DW648_RS10830_lanthipeptideNZ_QUJJ01000004.1 Lanthipeptides: DW748_RS03630_lanthipeptideNZ_QUJJ01000004.1 Lanthipeptides: DW748_RS03630_lanthipeptideNZ_QUKU01000006.1 Lanthipeptides: DXC27_RS05470_lanthipeptide

Lanthipeptides: PGY07_RS07085_lanthipeptide

24

ETRNSGGVLCTSTAEC

39

++ S GV+CT + EC

8

DSLASSGVVCTISVEC

23

13.5% NZ_NTSR01000034.1: Lanthipeptides: CN358_RS26370_lanthipeptide

30

GVLCTSTAECYF

41

G +CT +AEC F

20

GTMCTVSAECMF

31

11.5% NZ_VDYW01000008.1: Lanthipeptides: allorf_137107_137307_lanthipeptide

40

YFGTLLKPCCP

50

Y G +L CCP

10

YVGDILLNCCP

20

9.6% NZ_AP018194.1: Lanthipeptides: CA739_RS01285_lanthipeptide

39

CYFGTLLKPC

48

C+ T++KPC

2

CFVSTIIKPC

11

allorf_006607_006780

Leader:

MHFLWDIGQDLAAS

Core:

AVRSSLYQYPRGNYNWVCTKANLKYDFHITGQLMENHPEYSVA

Core with dehydrations:

AVRDhaDhaLYQYPRGNYNWVCysDhbKANLKYDFHIDhbGQLMENHPEYDhaVA

antiSMASH-DB 4.0 matches for allorf_006607_006780

18.6% NC_015215.1and 5 others:

NC_015215.1 Lanthipeptides: SGGBAA2069_RS00705_lanthipeptideNZ_JAKUYO010000004.1 Lanthipeptides: MK556_RS09795_lanthipeptideNZ_JAKUYO010000004.1 Lanthipeptides: MK556_RS09795_lanthipeptideNZ_JAMDHZ010000003.1 Lanthipeptides: M5Q10_RS05350_lanthipeptideNZ_JAMDHZ010000003.1 Lanthipeptides: M5Q10_RS05350_lanthipeptide

Lanthipeptides: SGGBAA2069_RS00705_lanthipeptide

5

SLYQYPRGNYNWVCT

19

SL GN WVCT

13

SLLSIGLGNDGWVCT

27

18.6% NZ_BCEY01000006.1and 1 other:

NZ_BCEY01000006.1 Lanthipeptides: GOZ53_RS01290_lanthipeptide

Lanthipeptides: GOZ53_RS01290_lanthipeptide

2

VRSSLYQYPRGNYNWVCT

19

V SL + GN W+CT

10

VSCSLISFALGNDGWICT

27

18.6% NZ_CP009288.1and 3 others:

NZ_CP009288.1 Lanthipeptides: PDUR_RS25150_lanthipeptideNZ_CP076607.1 Lanthipeptides: KP014_RS01580_lanthipeptideNZ_CP076607.1 Lanthipeptides: KP014_RS01580_lanthipeptide

Lanthipeptides: PDUR_RS25150_lanthipeptide

4

SSLYQYPRGNYNWVCT

19

S L GN WVCT

11

SILISMTLGNNGWVCT

26

with 6 more sequence matches

18.6% NZ_VTZW01000015.1and 1 other:

NZ_VTZW01000015.1 Lanthipeptides: FZ103_RS15850_lanthipeptide

Lanthipeptides: FZ103_RS15850_lanthipeptide

1

AVRSSLYQYPRGNYNWVCT

19

A S L + GN W CT

10

ACVSCLASWAVGNEGWACT

28

16.3% NZ_FQZK01000006.1and 1 other:

NZ_FQZK01000006.1 Lanthipeptides: BUE45_RS13115_lanthipeptide

Lanthipeptides: BUE45_RS13115_lanthipeptide

4

SSLYQYPRGNYNWVCT

19

S L + GN W CT

16

SCLASWAIGNPGWACT

31

16.3% NZ_JAQCPQ010000017.1: Lanthipeptides: PG021_RS13210_lanthipeptide

12

GNYNWVCTKAN

22

G N+ CTKAN

19

GMTNYCCTKAN

29

14.0% NZ_AP021901.1: Lanthipeptides: allorf_0929005_0929109_lanthipeptide

3

RSSLYQYPRGNYNWVC

18

R+SL++ + WVC

1

RNSLWERACSRWRWVC

16

14.0% NZ_FNUH01000004.1and 1 other:

NZ_FOGM01000011.1 Lanthipeptides: allorf_00913_01050_lanthipeptide

Lanthipeptides: allorf_005918_006055_lanthipeptide

21

ANLKYDFHI

29

+NLK+DF I

17

SNLKFDFKI

25

9.3% NZ_SLWS01000002.1and 3 others:

NZ_SLWS01000002.1 Lanthipeptides: EV192_RS10710_lanthipeptideNZ_SLWS01000002.1 Lanthipeptides: EV192_RS10710_lanthipeptideNZ_SLWS01000002.1 Lanthipeptides: EV192_RS10710_lanthipeptide

Lanthipeptides: EV192_RS10710_lanthipeptide

11

RGNYNWVC

18

RG ++W+C

9

RGTFSWMC

16

allorf_020220_020318

Leader:

MWKKKYRERGKSQGY

Core:

LKVTSRKSQCSWYIITV

Core with dehydrations:

LKVDhbDhaRKDhaQCysDhaWYIIDhbV

antiSMASH-DB 4.0 matches for allorf_020220_020318

100.0% NZ_CZAY01000009.1and 11 others:

NZ_CZBA01000009.1 Lanthipeptides: allorf_046797_046895_lanthipeptideNZ_CZBB01000003.1 Lanthipeptides: allorf_027211_027309_lanthipeptideNZ_JADPDU010000003.1 Lanthipeptides: allorf_107261_107359_lanthipeptideNZ_JAOQJU010000001.1 Lanthipeptides: allorf_163570_163668_lanthipeptideNZ_JAQCSY010000025.1 Lanthipeptides: allorf_10713_10811_lanthipeptideNZ_JAQEDC010000020.1 Lanthipeptides: allorf_15206_15304_lanthipeptideNZ_QRZZ01000001.1 Lanthipeptides: allorf_316866_316964_lanthipeptideNZ_QSUB01000001.1 Lanthipeptides: allorf_0632573_0632671_lanthipeptideNZ_QUCI01000019.1 Lanthipeptides: allorf_10688_10786_lanthipeptideNZ_QULD01000003.1 Lanthipeptides: allorf_363255_363353_lanthipeptideNZ_QULI01000007.1 Lanthipeptides: allorf_134293_134391_lanthipeptide

Lanthipeptides: allorf_037119_037217_lanthipeptide

1

LKVTSRKSQCSWYIITV

17

LKVTSRKSQCSWYIITV

1

LKVTSRKSQCSWYIITV

17

9.3% NZ_BJTV01000007.1: Lanthipeptides: allorf_023321_023548_lanthipeptide

7

KSQCSWYIIT

16

++ CSWY+ T

29

RTACSWYVRT

38

Legend:

Dha: Didehydroalanine
Dhb: Didehydrobutyrine

Lanthipeptides

Core peptide predictions

ctg19_15 - Class II

Cleavage pHMM score: -7.00

RODEO score: 0

Monoisotopic mass: 5354.6 Da

Molecular weight: 5358.1 Da

Number of bridges: 4

Alternative weights: (assuming N unmodified Ser/Thr residues); 5376.2 Da N = 1; 5394.2 Da N = 2

allorf_006607_006780 - Class II

Cleavage pHMM score: -5.40

RODEO score: 0

Monoisotopic mass: 4972.4 Da

Molecular weight: 4975.5 Da

Number of bridges: 1

Alternative weights: (assuming N unmodified Ser/Thr residues); 4993.5 Da N = 1; 5011.6 Da N = 2; 5029.6 Da N = 3; 5047.6 Da N = 4

allorf_020220_020318 - Class II

Cleavage pHMM score: -7.00

RODEO score: 0

Monoisotopic mass: 1921.1 Da

Molecular weight: 1922.3 Da

Number of bridges: 1

Alternative weights: (assuming N unmodified Ser/Thr residues); 1940.3 Da N = 1; 1958.3 Da N = 2; 1976.3 Da N = 3; 1994.4 Da N = 4

gnlProkkaBOONPHDL_25 - Region 1 - NRPS

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Location: 18,510 - 57,505 nt. (total: 38,996 nt) Show pHMM detection rules used

Region on contig edge.

NRPS: cds(Condensation and (AMP-binding or A-OX))

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core biosynthetic genes

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Gene overview

NRPS/PKS domains

KnownClusterBlast

NRPS/PKS modules

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Detailed domain annotation

Selected features only

Show module domains

Similar known gene clusters from MIBiG 3.1

Module view

Legend

NRPS/PKS products

NRPS/PKS substrates

Predicted core structure(s)

For candidate cluster 1, location 18509 - 57505:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (X - X - X)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

ctg25_42

AMP-binding (20..419): X

nrpys: Leu, Trp

SVM prediction details:

Predicted physicochemical class:: N/A
Large clusters prediction:: Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
Small clusters prediction:: Tiny, hydrophilic, transition to aliphatic (Gly, Ala)
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: DVLTDGGISK
Nearest Stachelhaus code(s):: Leu or Trp DVLTDGGISK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

AMP-binding (1033..1421): X

nrpys: Leu, Trp

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
Small clusters prediction:: Aliphatic, branched hydrophobic (Val, Leu, Ile, Abu, Ival)
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: DAMFSGAIFK
Nearest Stachelhaus code(s):: Leu or Trp DAMFSGAIFK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

AMP-binding (2027..2418): X

nrpys: Leu, Trp

SVM prediction details:

Predicted physicochemical class:: N/A
Large clusters prediction:: Aromatic side chain (Phe, Trp, Ph-Gly, Tyr, bOH-Tyr)
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: DAITTGGVSK
Nearest Stachelhaus code(s):: Leu or Trp DAITTGGVSK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

gnlProkkaBOONPHDL_64 - Region 1 - ranthipeptide

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Location: 38,042 - 59,630 nt. (total: 21,589 nt) Show pHMM detection rules used

ranthipeptide: (TIGR03973 or SCIFF or (cds(PF04055 and (TIGR04085 or SPASM)) and minimum(1, [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE, Cytolysin_C_RRE, Goadsporin_CD_RRE, Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE, Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE, Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE, Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE, Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE, Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE, Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE, Thiaglutamate_B_RRE, Thiaglutamate_G_RRE, Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE, Thurincin_rSAM_RRE, Trifolitoxin_RRE]) and not (TIGR01716 or subtilosin or TIGR02111 or TIGR03966 or TIGR04103 or (YcaO or TIGR03604))))

Legend:

core biosynthetic genes

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Gene overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Similar known gene clusters from MIBiG 3.1

No matches found.

gnlProkkaBOONPHDL_71 - Region 1 - cyclic-lactone-autoinducer

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Location: 1 - 7,942 nt. (total: 7,942 nt) Show pHMM detection rules used

Region on contig edge.

cyclic-lactone-autoinducer: (TIGR04223 or AgrB)

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core biosynthetic genes

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Similar known gene clusters from MIBiG 3.1

No matches found.

gnlProkkaBOONPHDL_108 - Region 1 - ranthipeptide

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Location: 8,413 - 31,028 nt. (total: 22,616 nt) Show pHMM detection rules used

Region on contig edge.

ranthipeptide: (TIGR03973 or SCIFF or (cds(PF04055 and (TIGR04085 or SPASM)) and minimum(1, [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE, Cytolysin_C_RRE, Goadsporin_CD_RRE, Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE, Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE, Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE, Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE, Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE, Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE, Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE, Thiaglutamate_B_RRE, Thiaglutamate_G_RRE, Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE, Thurincin_rSAM_RRE, Trifolitoxin_RRE]) and not (TIGR01716 or subtilosin or TIGR02111 or TIGR03966 or TIGR04103 or (YcaO or TIGR03604))))

Legend:

core biosynthetic genes

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Similar known gene clusters from MIBiG 3.1

No matches found.