LOCUS       c00140_gnlPro..        15145 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|NMJOGCBH_140.
ACCESSION   c00140_gnlPro..
VERSION     c00140_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-04 00:41:56
            Original ID  :: gnl|Prokka|NMJOGCBH_140
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 15145
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..15145
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[142:10263]"
                     /cutoff="10000"
                     /detection_rule="(Succ_DH_flav_C and FAD_binding_2 and
                     (Fer2_3 or Fer4_7 or SucD_FumR))"
                     /neighbourhood="10000"
                     /product="Fumarate2succinate"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      143..10263
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(Succ_DH_flav_C and FAD_binding_2 and
                     (Fer2_3 or Fer4_7 or SucD_FumR))"
                     /neighbourhood="10000"
                     /product="Fumarate2succinate"
                     /protocluster_number="1"
     cand_cluster    1..15145
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(Succ_DH_flav_C and FAD_binding_2 and
                     (Fer2_3 or Fer4_7 or SucD_FumR))"
                     /kind="single"
                     /product="Fumarate2succinate"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..15145
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="Fumarate2succinate"
                     /region_number="1"
                     /rules="(Succ_DH_flav_C and FAD_binding_2 and (Fer2_3 or
                     Fer4_7 or SucD_FumR))"
                     /tool="gutsmash"
     CDS             complement(79..204)
                     /locus_tag="ctg140_1"
                     /transl_table=11
                     /translation="MPMTPNTEQDWKAWRNLMWSEILTESVKSYMDCKCLNAISI"
     CDS             complement(143..1660)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Fumarate2succinate: Fer4_7"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_4"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg140_2"
                     /sec_met_domain="Fer4_7 (E-value: 1.3e-11, bitscore: 35.0,
                     seeds: 208, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4 (E-value: 1.6e-11, bitscore: 33.8,
                     seeds: 528, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_4 (E-value: 6.4e-06, bitscore: 16.7,
                     seeds: 79, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRGLYSSKTEIRHKIFTEIARMAYEGQSPEMLEELPYKIVPGEIA
                     TYRDSIFLERAVVGERLRVAMGMSLRKVTEHAPISKGVEASVIEEKYYEPPLINVIKFA
                     CNSCPEKRVMITEGCQGCLEHPCVEVCPKKAVHMEGGRSHIDEDACIKCGKCLEACPYN
                     AIIKQERPCSKACGMNAIGSDEYGRAEIDQDKCVSCGQCLVSCPFSAIVDKGQIFQTIM
                     ALKSETPVYAIVAPAIAGQFPGMENNKIRGAFQALGFTDVREVAVGADLCTVEEAKDFL
                     EEVPEKLPFMATSCCPSWSMMAKKLFPEQAKCISMALTPMVLTARLIKQKEPDCKIVFV
                     GPCAAKKLEASRKSIRSYVDFVLTFEEVAGMFDAKGVDWKDIPEGEPLFHASADGRGFA
                     VSGGVAEAVVHAVKRIDPDREVKVMNAEGLQNCKKMLQMAKIGKYNGYLLEGMACPGGC
                     VAGAGTIQTVKKAAAALEKMKKEASFTDAYDSKYRARLESLEKFDVE"
     CDS             complement(1926..2708)
                     /locus_tag="ctg140_3"
                     /transl_table=11
                     /translation="MIFTKKYRTGQIVLTACIAAVCMFSDVHGAEVAGPPAPKSKSALT
                     QKPEATPMPEATPIPASTPTPEQETETDKQNPADQGTLSKPDHPDTISADKLVFIGDSR
                     TEGLRDAVNDDSIWSCLSSMGYDWMVSTGVPQVEDQIEDNTAVIILMGVNDLYHVNDYI
                     SYINSKAAEWGNRGAQTYFVSVGPVQNDPYCSNAEIESFNAAMQASLSGVTYIDVYSHL
                     VSEGFSTVDGTHYPDSVSVDIYNYILDHLEEQMSGIWG"
     CDS             complement(2686..2814)
                     /locus_tag="ctg140_4"
                     /transl_table=11
                     /translation="MAGYAAWDVSMLLFTATHSRELRYVKSNVSITAEGNDIYEKI"
     CDS             complement(2787..3041)
                     /locus_tag="ctg140_5"
                     /transl_table=11
                     /translation="MRLEKVQEALKTKKIHYEYTEENGCGSIDFMFRGLRFHIWEYEDR
                     VWGAETNVFEAGRSQDIEGDYEEIISGEILSWPDMLPGM"
     CDS             3586..4923
                     /locus_tag="ctg140_6"
                     /transl_table=11
                     /translation="MFHLKLKDTLKHSIATVTSHMDSFVYNPGRDYSRIRKLSPDHVIS
                     FLISQGASSTKCEFLDFFQMSEDLPSISALNQRRSQMMPEALEAVFHEFTSSSEKLELS
                     KQEQQYQYIAADGSTTSFFSFSKYSSDDYFISEGHSASGFYSIHINAFYDINKRIYTDA
                     ILQSAHKKDEFLAFCQLVDRHIPHPDQRTIFIGDRGYCSYNNMAHVIEKEQYFVFRTKD
                     ITSKGLIGNFVFPDSDTFDITVDVTLTRSHRKSIKIKDGFYRRYVDQAASFDYIKYGSE
                     DTYDLTFRIVRFPISEDTYECLVTNLPEKNFPVEKLKEIYNSRWGIESSFRKLKYTIGL
                     SHYHSYKPDFIKQEIWAKFIAYNATELLVAHTVVVHGKRKYSYKVNFTLAAHICRIYLR
                     LHTETDSINVMALLQKELVPIRCDRQFPRLKTAHFRKPKYLIYRVS"
     CDS             complement(5416..7056)
                     /locus_tag="ctg140_7"
                     /transl_table=11
                     /translation="MKGLLKFITCGSVDDGKSTLIGHILYDAKLLYADQEKALELDSKV
                     GSRGGAIDYSLLLDGLMAEREQGITIDVAYRYFTTDNRSFIVADTPGHEEYTRNMAVGA
                     SFADLAVILVDASQGVLVQTRRHARICALMGIRYFVFAVNKMDLIEYDEKRFRDIENQI
                     AALIEELKLANVTIIPVSATEGDNVTTKSDNMPWYKGEALLSHLETVDIKEDTEKGFYM
                     PVQRVCRPNHEFRGFQGQIENGAIRAGDLVTTLPSKEEAHVKSILVGDKEVQEAVQGQP
                     VTIQLDREVDVSRGCVLTIDSGAVLTDSVEADILWMDDNALTDGKNFFVKIGTKMIPGL
                     VTKINYSVDVNTGEKKSAYTLKKNEIASCTLEFSEKIVVDEFDRHRTLGELILIDRVTN
                     MTSACGVVRKTFVSQDRSQIGKVDEQVRAGLKGQTPVVVEFPIGKEGITLDFAEQVEKR
                     LTVLGKHTYLYHPAASENYAETVRHLKAAGLIVLLVLDENTAKDETLKTLDGFYANWQI
                     DGITVKDAIDFVKKKSAFTVQSVHDGNYI"
     CDS             complement(7058..8176)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PAPS_reduct"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg140_8"
                     /sec_met_domain="PAPS_reduct (E-value: 4.5e-65, bitscore:
                     208.9, seeds: 27, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="VCLKNALRKMCVTICGRFCSDEGVVAGYDNRIRTKYTAKWGVQIA
                     GMIFQTRSSVFAQVRKDSEYKQTEEDNAMSNLSHLDALEAEAIYIMREVAAECEKPVML
                     YSIGKDSSVMLHLAMKAFYPEKPPFPFLHIDTTWKFHEMIEFRDRIAKENGIDMLVYTN
                     EEGVKAGINPFDNGSAYTDIMKTQALKQALTKYGFTAAFGGGRRDEEKSRAKERIFSFR
                     NSAQAWDPKNQRPEMWKLYNTKIQKGESMRVFPISNWTEKDIWQYIQRENIEIVPLYFA
                     KERPVIYRDGNIIMVDDDRLKLRPGEKIENKKVRFRTLGCYPLTGGIESEADTLDEIID
                     ETLSAVSSERTSRVIDHEAAGSMERRKREGYF"
     CDS             complement(8207..8521)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_9"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_6"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_4"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg140_9"
                     /sec_met_domain="Fer4_9 (E-value: 2e-13, bitscore: 40.4,
                     seeds: 61, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_6 (E-value: 2.9e-09, bitscore: 26.9,
                     seeds: 134, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_4 (E-value: 2.9e-05, bitscore: 14.6,
                     seeds: 79, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSIRIQKSKCAGCGRCIEACPGNLIKKDKENKAFIRQVRDCWGCT
                     SCIKECRHDAIRFFLGADVGGRGASMVVSEKPDISTWTVEKPDGTKITIQVNKKDANKY
                     "
     CDS             complement(8518..10263)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Fumarate2succinate: FAD_binding_2"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Fumarate2succinate: Succ_DH_flav_C"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1027:FAD binding domain (Score: 71.4; E-value:
                     2.7e-22)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg140_10"
                     /sec_met_domain="FAD_binding_2 (E-value: 6.4e-23, bitscore:
                     71.4, seeds: 62, tool: rule-based-clusters)"
                     /sec_met_domain="Succ_DH_flav_C (E-value: 1.1e-08,
                     bitscore: 25.2, seeds: 739, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRTERIRTDVLIIGGGTAGCFAAYVIGKKSGRKVLIAEKANIKRS
                     GCLAAGVNALNAYITEGRVPQDYVDYAKKDAHGIVREDLLLTMSERLNHVTKVMEDLGL
                     VILKDENGKYVARGNRNIKINGENMKPILAKAAAEQENVTVLNHVNITDYKTENKKVTG
                     AVGFSVNEDIFYDIDAKAVLCATGGAAGLYRPNNPGFSRHKMWYPPFNTGAGYAMGLLS
                     GAEMTTFEMRFIALRCKDTIAPTGTIAQGVGARQVNAHGDIYETKYGLTTSQRVYGTVM
                     ENREGNGPCYLRTEGISKEQEQDLYKAYLNMAPSQTLKWMEAGKGPSEENVEIEGTEPY
                     IVGGHTASGYWVDNNRATTIEGLYAAGDVAGGCPQKYVTGALAEGEIAAEAILEYLNGK
                     DDDRIAAENKEEALERGGEQELSQTAIAKKAEYESHLNASRSLMNAEQLEEAMQKIMDQ
                     YAGGIGTDYRYSGMSLAKADEKIAALLPVVDTLAATDTYELMQIYELRERLIVCQAVIA
                     HLAARKETRWHSFGENTDYPQQSEEWMKYVNSRMENGEIKIVYRDLITKENTGLNTAEK
                     GAGER"
     CDS             complement(10375..11433)
                     /locus_tag="ctg140_11"
                     /transl_table=11
                     /translation="MYVELKNINKTYGSYQASRNVNFGIEKGKLIGLLGPSGSGKTTIL
                     RMIAGLETPDSGEVIIDGKVVNDVPASQRGIGFVFQNYALFRYMTVYDNVAFGLKVQKA
                     DKKKIDARVRELIKLVGLEGLEKRYPSQLSGGQRQRVAFARALAPNPQVLLLDEPFAAI
                     DAKIRQELRSWLKEMIGKLGITSIFVTHDQDEAIEVADEIIITNAGRIEQKGTPIGVYR
                     NPETAFTASFFGQPSVLKNADDFHTFAQAEGADKIIVRPEFVKISKLDEVEKFKTSVSR
                     GVVERVSFRGDNLELQVRVNNSVVTARRSLEKADIREGETVNVFLYRIFALRGDSVQLI
                     ENEAVRDDFVII"
     CDS             complement(11435..12259)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) BPD_transp_1"
                     /gene_functions="transport (smcogs)
                     SMCOG1004:Binding-protein-dependent transport system inner
                     membrane component (Score: 59.9; E-value: 8.7e-19)"
                     /gene_kind="transport"
                     /locus_tag="ctg140_12"
                     /sec_met_domain="BPD_transp_1 (E-value: 2.1e-19, bitscore:
                     59.9, seeds: 81, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDNNEKTSEKITKWLLVGISVLFLAVMLLLPLITVITEALRSGWK
                     VYAAAVTDEYTIKALLLTVKATLFAVVFNTVFGVFAAWAMTKFQFRGKKLLTTLIDLPV
                     TISPVIAGLIFLLIFGRQSPVYFFLMKLGIKVVFSVPGIIIATVFVTFPFISRELIPVL
                     EAEGSDEEEAAALMGAGGWTIFWKITFPHIKWALLYGVVLCTARAMGEFGAVSVLSGHL
                     RGKTNTLPLHVEILFNEFQYVPAFAVSSLLVIMAVIILVVRSLIEYKGKKEA"
     CDS             complement(12259..13095)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) BPD_transp_1"
                     /gene_functions="transport (smcogs)
                     SMCOG1004:Binding-protein-dependent transport system inner
                     membrane component (Score: 83.4; E-value: 5.4e-26)"
                     /gene_kind="transport"
                     /locus_tag="ctg140_13"
                     /sec_met_domain="BPD_transp_1 (E-value: 1.3e-26, bitscore:
                     83.4, seeds: 81, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKKRNKPVIPGFELSMGITISILSLVVLIPLASLVVYTAKLSFKD
                     IIETITRARVLASFYTSFVCAFAAAVINGIMGTILAWVLVKYDFPGKRLMDGMIELPFA
                     LPTAVAGIALTSLTSDSGIVGSFFAGFGIKIAYTRIGITVAMIFVGIPFVVRSVQPVLE
                     KMDNSYSEAAGVLGAKKTTIFWKVIFPELKPAIFAGTGLAFGRCLGEYGSVVFIAGNKP
                     YYTEITPLVIMSELQEFDYSSATAIALVMLAVSFFILFLNSMIQQRNARILRGGNA"
     CDS             complement(13166..14164)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) SBP_bac_1"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1044:Bacterial extracellular solute-binding protein
                     (Score: 57.1; E-value: 9.3e-18)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg140_14"
                     /sec_met_domain="SBP_bac_1 (E-value: 2.2e-18, bitscore:
                     57.1, seeds: 129, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIRKLFAFGLAVVLALMPVQAFGKTVSVTNVSYDPTREMFEQYNK
                     IFEDHWKEKTGEDVEVIQSHGGSGKQALEVANGLDADVVTLALEYDIESIENAGLIKAG
                     WKDKFDNDSSPYTSTIVFLVKKGNPKDIKDWDDLTKKGVGVVTPNPKTSGGARWNYMAA
                     WAYADKKYGGDEAQMKEFIKKLYRNVVVLDSGARGATTSFVENGQGDVLVAWENEAYLS
                     MRDYPDEYEIVTPSVSILAQPSVAVVDEVVDYRDTRDVATEYLNYLYSDEAQEIAAENY
                     FRPTNEKILKKHSDTFDLNINLANISDYGGWDKVQEKHFTDGGIFDQIYER"
     CDS             complement(14367..14855)
                     /locus_tag="ctg140_15"
                     /transl_table=11
                     /translation="MPKNKFQEVIFTIIMVFVMVYAMICYNIVLNTGTMTNETFLLAFH
                     ELTFMGPIAFILDFFIIGGLAKKIAFGVVDMRRDNPFHLVLAISAVSVAFMCPCMSFAA
                     TVLIKHAPASQIIPTWLQTTAMNFPMAFFWQIFYAGPFVRFIFGKLFPEKEKAAASAE"
ORIGIN
        1 ggatgcaccc tgaaaaaagg cggtatcccg ccttaattca gatgctctgg taactcagtt
       61 gccgagtaat tcactctgct atatactgat tgcattcaaa cacttgcaat ccatatagga
      121 tttcactgat tcagtcagaa tctcactcca catcaaattt ctccaggctt tccagtcttg
      181 ctctgtattt ggagtcatag gcatctgtaa acgaagcctc tttcttcatt ttttcgagag
      241 ctgctgctgc ttttttaact gtctggatag taccggcacc tgctacacag ccgcccggac
      301 atgccattcc ttccaaaaga tatccattat atttaccaat cttggccatc tggagcatct
      361 tcttacagtt ctgcagacct tctgcattca ttacctttac ttcccgatca ggatcaatac
      421 gcttcaccgc atggacaacc gcttctgcca caccaccgct gactgcgaaa cctcttccgt
      481 cagcactggc atgaaacagt ggttctcctt ccggaatatc tttccagtcc acgcctttgg
      541 catcaaacat tcctgctact tcctcgaagg tcagcacaaa atccacatag ctgcggatac
      601 tcttacggct ggcttccagc ttcttggctg cacagggacc tacgaaaacg atcttacaat
      661 ctggttcctt ctgcttgatc agccttgcag tgagaaccat aggtgtcagt gccatagaga
      721 tacatttcgc ctgttccggg aataatttct tagccatcat agaccaggac ggacaacagg
      781 atgtagccat gaaaggaagt ttctcaggaa cttcttccaa aaagtccttt gcctcctcca
      841 ctgtgcacag atctgcaccg acggcaacct ctcttacatc tgtaaagcca agtgcctgaa
      901 atgctccccg tatcttatta ttctccatac ccggaaactg gcctgcaatg gcaggcgcca
      961 cgattgcata caccggtgtt tcacttttta atgccataat agtctggaaa atctgtcctt
     1021 tgtctacaat agcactgaac ggacaactta ccagacattg tccgcaggat acacatttat
     1081 cctgatcaat ctctgctctt ccatattcat cagagccaat agcattcata ccgcatgcct
     1141 ttgaacatgg acgttcctgt ttgatgattg cattatacgg acaggcttcc agacactttc
     1201 cgcatttgat acaggcatct tcatcaatat gggatctgcc gccttccata tgcactgctt
     1261 tctttggaca gacttccaca cagggatgct ccaggcaccc ctgacagccc tctgtgatca
     1321 ttaccctttt ttcagggcag gaattacagg caaacttgat cacattgata agcggcggtt
     1381 cataatactt ttcctcaata acgctggcct ccacaccttt ggaaattggc gcatgctctg
     1441 taacctttct cagtgacatc cccattgcaa cgcgaagtct ctcaccaact accgctcttt
     1501 ccagaaaaat actgtcacga taagtcgcaa tttcaccggg tacgatcttg tagggaagct
     1561 cttccagcat ctccggagac tggccttcat atgccatcct cgcaatttct gtaaaaattt
     1621 tgtgtctgat ttctgttttg gatgaataca gtcctctcat tttttcctcc tgattttcga
     1681 ttcggataac tgtacggcaa tccaatgcag ggacaccgaa caatttccat ttataatttc
     1741 atcactgctg caatcagcac actcattttt cctcctgctg aactttcagc cacttcacag
     1801 agaaacgaaa ttccgctcat ttccgtttcc ttatctgcat atcatatcac caaatgcttc
     1861 caggctcaac acaacatcag aattttcgct gaattgtcgc ccccgaagtt gctgttcata
     1921 tgttgttatc cccagattcc actcatctgt tcctccagat ggtccaagat ataattataa
     1981 atatctacgg acacactgtc cggatagtgg gttccgtcta cggtggaaaa tccctcagat
     2041 accagatggg aatatacgtc tatgtaggta actccactca ggcttgcctg cattgccgcg
     2101 ttaaaacttt caatctccgc attactgcaa tagggatcat tctgcaccgg acctacagac
     2161 acgaaataag tctgcgctcc tctgttcccc cattcagcag ctttggaatt aatataactg
     2221 atgtagtcat tgacatgata aagatcatta acacccatca ggataataac cgctgtattg
     2281 tcctcaatct gatcttctac ctgcggcact cctgtagata ccatccagtc atatcccata
     2341 gaagaaagac aggaccaaat gctgtcatcg tttaccgcat ccctcaatcc ctctgttctg
     2401 gaatctccga taaataccag tttatctgcg gagatagtgt ccggatggtc tggcttgctt
     2461 aaagttccct ggtctgccgg attctgttta tctgtctcag tttcctgctc cggtgttgga
     2521 gtagatgcag gtattggtgt tgcttcaggc attggtgttg cttcaggttt ttgtgtcagt
     2581 gccgatttgg atttcggtgc cggcggacct gccacttctg ccccatggac atctgaaaac
     2641 atacagacag ctgcaataca tgcggttaat acgatttgtc cggttctata ttttttcgta
     2701 aatatcattc ccttctgcag taatacttac gttacttttc acatatctca actccctgga
     2761 gtgtgttgct gtgaacagta acatacttac atcccaggca gcatatccgg ccatgagagg
     2821 atttctccgg aaataatttc ctcgtaatct ccttcaatat cctggcttct gcctgcttcg
     2881 aacacgtttg tctccgctcc ccagacacga tcttcatatt cccatatatg gaatctcaga
     2941 ccgcgaaaca taaagtcgat gcttccgcat ccattttcct ctgtatattc ataatgaatt
     3001 ttctttgttt ttaacgcttc ctgtactttt tccaaacgca taaaatacct cctgattatc
     3061 tgtacagtac cttctgtaat ataatacaga taactttcac tgtaaaaaaa tgttctcgtg
     3121 tacacccatc aaaagtcaaa cagatattcg caatccgctt cgctacacag ctctacatat
     3181 gctcttaatc ctgacgccat tatacaaaac gaattatatc atactctgct gcataatatg
     3241 taatctgaat gccacttcac aattgccgtt actgttcact ccgttcatag taacttagcc
     3301 aaaattcatt ccagattgcc tgtggcaata gaattttggc ttgtatgtct cgggattttg
     3361 gcatattcat gccaaaacac ctcgcgggat agtggtgtgt gaaccaatgg tatttagata
     3421 atctataccc ttagttagtc ttaagggtct aacaaaaaga ttacaaaagc cttgactttt
     3481 aagctggaat ctgcggccgc tctcattact gatattattg tgaggtaatg agagcggcct
     3541 ttgaattaga aattaaaatt tttctaattc aggaggcaca tacctatgtt ccatttaaaa
     3601 cttaaagata ctcttaagca ttctatagca acggttacat cgcatatgga ttcctttgtt
     3661 tataatccgg gacgcgatta ttctcgtata cgaaaacttt ccccagatca tgttatttcg
     3721 ttccttattt ctcaaggcgc ttcatccacg aaatgcgaat ttctggattt ctttcaaatg
     3781 tcagaggatc tcccttctat atctgcccta aatcaaaggc gttcccaaat gatgccagag
     3841 gctctggaag ctgtattcca tgagtttact tcttcttccg aaaagcttga actttcaaag
     3901 caggaacagc agtatcaata cattgctgct gatggttcta ctacttcttt tttcagcttt
     3961 tcaaagtatt cgtctgatga ttattttatc tcagaaggac attctgcctc cggcttttac
     4021 agcatacaca ttaatgcctt ttatgacata aataaacgga tctataccga tgccattctt
     4081 cagtctgcac acaaaaaaga tgagttcctt gctttttgcc agcttgtaga cagacatatc
     4141 cctcacccgg atcaaagaac tatttttatc ggggacagag ggtattgctc ttataacaac
     4201 atggctcacg tgatcgaaaa agaacagtat tttgtttttc gtacaaaaga cattacaagc
     4261 aaagggttga ttgggaactt tgtttttccg gattctgata catttgatat aactgttgac
     4321 gtaactctta cgagatccca tcgtaaatct ataaaaatca aagatggttt ttaccgaaga
     4381 tatgttgacc aggcagcttc ttttgactac ataaaatatg gctcagaaga tacttatgat
     4441 ctgacttttc ggatcgtacg gtttccaata tcagaagata cttatgaatg ccttgtgaca
     4501 aatcttccgg aaaaaaactt tcctgttgaa aagcttaaag aaatctataa ttccagatgg
     4561 gggatcgaat cctcttttcg aaaattgaaa tatacgattg gattaagtca ttatcacagc
     4621 tataaacctg attttataaa acaggaaata tgggcgaagt ttatcgctta taatgccacg
     4681 gaacttcttg ttgctcatac tgtagtcgtt catgggaaac gtaaatattc ctataaagta
     4741 aactttacgc ttgctgcaca tatatgcaga atctatctcc gtctccacac ggagacagat
     4801 tccataaatg tgatggcact gttacaaaag gaattagtcc cgatccgctg cgatcgacaa
     4861 ttcccaagac ttaaaacggc tcatttcaga aaacccaaat atctgatata ccgtgtttcc
     4921 taaacagtat catcaactga tagtatatca ctttttcaag cagatgaaaa tctgcttatt
     4981 tgtcgttgac aaaacgaaca agaatttaac cattttcata tttcataaat ttttcaaggc
     5041 atttcttttt aaatgtcaag taatctccgg aatatgcttt atttatctaa ataccattgg
     5101 tgtgtgaaca gtaaccaatt gcccattcta cattctgatc gatattcact catctttatt
     5161 tctgtctttt cttcgttggt atcgccagga tgatgatcgt agcaattaca aacaaagttc
     5221 caagcatcat ctcttttttg ggttttgttt actttcattg ttcgtttgca tatttctgtt
     5281 atctttcctg tctgtattat tatggattct gaatatttga aaataagtat aatccgctgt
     5341 aacgacactt gtcaagaaaa caaaataccg cagagacttt ctttgtctct gcggcgattt
     5401 atagccctgt tataatcaga tataatttcc atcatgtaca ctctgcactg taaatgcaga
     5461 tttctttttc acgaaatcaa tcgcatcttt cacagtgatt ccgtcaatct gccagttcgc
     5521 atagaaacca tccagagtct ttaatgtctc gtcttttgct gtattttcat caagaacaag
     5581 aagtacgatc agacctgctg ccttaagatg gcggacagtt tctgcatagt tttcactcgc
     5641 tgccggatga tacagatagg tatgttttcc aagtacagtc agtctctttt ctacctgctc
     5701 tgcaaaatca agagtgattc cttctttacc gatcgggaat tccactacta ccggtgtctg
     5761 acctttcagt cctgcgcgaa cctgctcgtc cacttttccg atctgggatc tatcctgaga
     5821 aacaaaggtt tttctcacaa caccgcaggc agaagtcata tttgtgacac gatctatcag
     5881 gatcagctcc cccagtgttc tgtgcctgtc aaattcgtct acaacgatct tctctgagaa
     5941 ttccagagta caggaagcaa tctcattttt ctttaaggta tatgcgcttt tcttttcacc
     6001 tgtattaaca tccacagaat aattgatctt tgtaaccagg ccggggatca tctttgtacc
     6061 gatttttaca aagaagttct tgccatccgt aagagcattg tcatccatcc agaggatatc
     6121 tgcttccaca gagtctgtaa gaactgcacc ggaatcaatg gtaagtacac atccgcggga
     6181 aacatctact tctctgtcaa gctggatggt aacaggctgt ccctgtacag cttcctgaac
     6241 ttctttatcg ccaacaagaa tgctctttac atgagcttct tctttactgg gaagagtagt
     6301 cacaaggtcg cctgccctga tggcaccatt ctcaatctgt ccctggaatc cgcgaaactc
     6361 atggtttggt ctgcagactc tctgtacagg catatagaag cccttctctg tatcttcctt
     6421 aatgtctacg gtttccagat gggaaagaag cgcctcacct ttataccatg gcatgttgtc
     6481 agatttggtt gtaacgttgt caccttctgt ggcagatacc ggaataatag ttacattggc
     6541 aagtttcagt tcttctatca gtgctgcgat ctgattctca atgtcgcgga aacgtttttc
     6601 atcatattca ataagatcca ttttgtttac tgcaaataca aagtaacgga ttcccatcaa
     6661 tgcgcagatt cttgcatgac gtcttgtctg taccagtact ccctgtgaag catccaccag
     6721 gataactgcc agatctgcaa aggacgcacc cactgccatg tttcttgtat attcttcatg
     6781 tccgggtgta tctgcaacaa tgaagcttct gttatctgtt gtaaaataac ggtatgcaac
     6841 atcaatggtg attccctgtt cacgctctgc catcagaccg tccagaagaa gagaataatc
     6901 aatggcaccg cctctgcttc ctactttgga atccagctcc agggctttct cctgatctgc
     6961 atagagaagc tttgcatcat aaagaatatg tccgatcaga gtggattttc catcatccac
     7021 acttccgcat gtaataaatt tcaataatcc tttcattcta gaaatacccc tctctctttc
     7081 ttctctccat gctgcctgct gcctcgtggt cgatcaccct gctggtacgt tcagaagaaa
     7141 cagcacttaa tgtctcatca ataatctcat ccagagtatc tgcttcagat tcaatacctc
     7201 cagtaagcgg atagcatcca agagtacgga atctgacttt tttgttttca atcttttcac
     7261 ccggacggag ttttaatctg tcatcatcca ccataatgat atttccgtct ctgtagatga
     7321 ccggtctttc ttttgcaaaa tataacggta caatttcaat attttcacgc tgaatgtact
     7381 gccagatatc cttttctgtc cagttggaaa ttggaaatac tcgcatactc tcgcccttct
     7441 ggatcttagt gttataaagc ttccacatct ccggtctctg gtttttcgga tcccatgcct
     7501 gagctgaatt acggaaagag aagattcttt cttttgctct ggatttctcc tcatcacgac
     7561 gaccgcctcc aaatgccgct gtaaatccat atttggtcag agcctgtttt aaggcctgtg
     7621 ttttcatgat atctgtatat gcagaaccat tgtcaaatgg gttgattcct gcctttacac
     7681 cctcttcatt ggtgtaaacc agcatatcaa ttccgttttc ctttgcgatt ctgtcgcgga
     7741 attcgatcat ctcatgaaat ttccatgtag tatcaatgtg aagaaaggga aaaggcggtt
     7801 tctccgggta aaatgccttc atcgccagat ggagcataac ggagctgtcc tttcctatag
     7861 aatagagcat aaccggcttt tcacactcgg ctgctacttc tcgcataata taaatcgcct
     7921 ctgcctcaag cgcatcaaga tgagataagt tactcattgc attatcctcc tctgtttgtt
     7981 tatactcgga atcttttcgt acttgagcaa atacactaga gcgtgtctga aaaatcattc
     8041 ccgcaatctg cacgccccac tttgcggtat attttgtccg aattcggttg tcgtagcccg
     8101 ctacgacgcc ctcatccgaa caaaatctcc cacaaattgt gacgcacatc ttgcgtaaag
     8161 catttttcaa acacactcta aagactctga gaatacatac ttatgtttaa tatttattag
     8221 cgtctttctt attaacctga atagtgatct tagtgccatc cggcttctcc actgtccatg
     8281 tggaaatatc cggtttctct gatacaacca tacttgcacc tctgcctccc acatcagctc
     8341 caaggaaaaa gcggatggca tcatgcctgc attccttaat acaggaagta catccccagc
     8401 agtctcttac ctgacggata aaggctttgt tctctttatc ctttttgatc agatttccgg
     8461 gacaggcttc gatacatctg ccgcatcctg cacatttact tttctgaatc cgaatgctca
     8521 tctctcacct gctcctttct ctgctgtatt caaacctgta ttttcctttg tgatcaggtc
     8581 acgatatacg atcttaatct cgccgttttc catacgggag tttacatatt tcatccactc
     8641 ttcgctctgc tgcgggtagt ctgtattctc tccgaaacta tgccatctgg tttcctttct
     8701 ggctgccaaa tgtgcgatca ctgcctgaca cacgatcagt cgttcgcgaa gttcataaat
     8761 ctgcatcagt tcataagtat ctgttgctgc cagagtgtca actactggca acaatgctgc
     8821 gatcttttca tctgcctttg caagactcat cccgctgtat ctgtagtctg taccgattcc
     8881 tcctgcgtac tgatccatga tcttctgcat ggcttcctca agctgctctg cattcatcaa
     8941 agaacgggaa gcattcaaat gtgattcgta ttctgccttc ttagctattg cagtttgaga
     9001 cagctcctgt tctccgccac gctctaaagc ctcttcctta ttttccgctg cgatccggtc
     9061 atcatctttg ccattcagat attccaaaat cgcctctgct gcgatctcac cttctgccag
     9121 tgcgccggtt acatatttct gcggacatcc tcctgctacg tctccggctg catataaacc
     9181 ttcaatagtt gtagctctgt tattatctac ccagtaaccg ctggctgtat gtccgcctac
     9241 aatatatggt tctgtgccct caatctctac attctcttcg gatggtcctt ttccggcttc
     9301 catccatttc agagtctggg acggtgccat attcaggtaa gctttataaa ggtcctgctc
     9361 ctgttctttg gaaatgcctt ccgttctgag ataacatgga ccgtttcctt ctctgttctc
     9421 catgactgta ccgtaaactc gctgggaagt tgtcagacca tattttgttt cataaatatc
     9481 accatgtgca ttgacctgtc tggccccaac accctgagca atagttcctg taggagcaat
     9541 cgtgtcctta catctcaatg caatgaaacg catctcaaag gttgtcatct ccgcaccgga
     9601 aagaagtccc attgcatatc ctgcacctgt gttaaacgga ggataccaca tcttatgtct
     9661 ggaaaatccc ggattattcg gtctgtaaag tcccgctgca ccacctgtgg cacaaagaac
     9721 tgctttcgca tcaatgtcat agaaaatatc ctcattaacg ctaaatccaa ctgcgcctgt
     9781 gacttttttg ttttctgttt tataatctgt aatatttaca tgattgagaa ccgtaacatt
     9841 ctcctgttca gctgccgcct ttgcaaggat tggcttcata ttttcgccat tgatcttgat
     9901 gtttcggttt cctctggcaa catattttcc gttttcgtcc ttcaggatga ccagccccag
     9961 atcttccatc acctttgtca catgattcag tctctctgac atggtaagaa gaaggtcttc
    10021 tcttacgatt ccatgggcat cctttttggc ataatccaca taatcctgtg gcactctgcc
    10081 ttctgtaata tatgcgttca atgcattcac gcccgccgcc agacatccgc ttcgcttaat
    10141 attcgctttc tctgcgatca gaacttttct gccgcttttt ttgccgatca cataggctgc
    10201 aaagcatcct gccgtaccgc cgccgatgat cagcacatct gtcctgattc tctctgttct
    10261 cattctctct taccctttcc tccataccag tgtgccaaca agttgatttt ccgatcagtc
    10321 ttgcctctga atttcttatt tcttcattgt cgtcagtcgc cgcagccacc gttgtcagat
    10381 aattacaaag tcatccctta cagcctcatt ttcgatcagc tgtacactgt cacctctcag
    10441 tgcaaaaatc ctgtaaagga atacattcac agtctcacct tcccggatat ctgctttctc
    10501 caggcttctt ctggcagtta ctacggaatt gttgactctc acctgaagtt ccagattatc
    10561 tcccctgaaa gaaacccgtt caaccactcc ccgggatacg gaagttttga acttctctac
    10621 ctcatccagt ttggagattt ttacaaattc cgggcggaca atgatcttgt ctgctccttc
    10681 tgcctgagca aaggtatgga aatcatccgc atttttcaac acagatggct gtccgaagaa
    10741 ggacgctgta aaagctgtct caggatttct gtaaacccct ataggagttc ctttctgttc
    10801 gatccgtcct gcattagtga taataatctc atctgctact tcaatggcct catcctgatc
    10861 atgagtaacg aaaatactgg taattcccag ctttccgatc atctctttta accagcttcg
    10921 cagttcctga cggatttttg catcaatggc tgcaaagggc tcatccagaa gcagcacctg
    10981 gggatttgga gcaagggctc tggcaaatgc caccctttgc ctctgaccgc cggataactg
    11041 gcttggatat cttttttcca gtccttccag ccccaccagt ttgatcagtt ctctgactct
    11101 ggcatcaatt ttcttcttat cagccttctg aaccttcaaa ccaaatgcaa cgttgtcata
    11161 aactgtcata tagcgaaaca acgcataatt ctgaaataca aatccaatcc cacgctgact
    11221 ggccggaaca tcatttacca cttttccatc aataattacc tctccgctgt ccggggtttc
    11281 cagacctgcg atcattcgaa gaatagttgt ttttccgctt ccgcttggtc ccaacagacc
    11341 aatcagttta cctttctcaa ttccgaaatt cacattcctt gatgcctggt aagaaccata
    11401 tgtcttattg atatttttta actctacata catatcaggc ttccttcttt cctttatatt
    11461 caatcaggct tctgactacc agaatgataa ccgccatgat cacaagcagt gaagatacgg
    11521 caaatgccgg aacatactga aactcattaa acaaaatctc tacatgaaga ggaagtgtat
    11581 tggtctttcc tcttaaatgt ccggaaagta cagataccgc tccaaactct cccattgctc
    11641 ttgccgtaca gagcacaact ccatacagta atgcccattt gatatgaggg aatgtgatct
    11701 tccagaaaat ggtccatcca cctgctccca tcagggctgc cgcttcctcc tcatcgcttc
    11761 cttctgcttc cagaaccgga atcagttctc tggaaataaa aggaaaggtt acaaatacag
    11821 ttgcaataat gattcccggt acagagaata caactttaat ccctaacttc atgagaaaaa
    11881 agtaaacagg actctgtcgt ccgaaaatca gaagaaagat caaacctgca ataacagggg
    11941 aaatagtaac cggaagatcg atcagggtag tgagaagctt tttacccctg aactgaaact
    12001 tcgtcattgc ccaggctgca aaaacaccaa aaacagtgtt aaaaacaact gcaaagagtg
    12061 ttgccttcac tgtaagaaga agtgctttga tggtgtactc atctgtcact gcagctgcat
    12121 agaccttcca tccgctccgc aatgcttctg tgatcacagt gatcagagga agaaggagca
    12181 tgactgccag aaacagaaca ctgatcccga caagcagcca ttttgtaatt ttctccgaag
    12241 tcttttcatt gttgtccatc aggcatttcc tcctcttaaa attcttgcat ttctctgctg
    12301 tatcatactg ttaagaaaca gaatgaaaaa tgaaactgcc aacatcacaa gtgcgattgc
    12361 cgttgcactt gaataatcaa attcctgaag ctctgacata ataaccagcg gtgtgatttc
    12421 tgtataatag ggtttatttc ctgcgataaa tacaacactt ccatattcac ccagacatct
    12481 tccgaacgca agtccggttc ccgcaaagat tgcgggcttc agttccggaa aaatgacctt
    12541 ccagaagata gttgttttct ttgctcccag cactcctgct gcctcgctgt aagaattatc
    12601 catcttttcc agaaccggct gtacacttcg cacaacgaac ggtattccta caaatatcat
    12661 agccactgta atacctattc ttgtgtatgc gatcttgata ccgaatcctg caaaaaagct
    12721 gccgacaatt cccgaatctg aggtcaggga tgtcagtgca atacccgcta ccgctgtggg
    12781 aagagcaaag ggaagttcga tcatcccatc cataagtctc ttgcccggaa aatcatattt
    12841 cacaagcacc cacgcaagaa tagttcccat aattccattt attactgctg ctgcaaaagc
    12901 acatacaaaa ctggtataaa aggatgccaa cactctggcc cttgtgatgg tttcgataat
    12961 atctttaaaa ctcagcttcg ctgtgtagac caccaggctt gccaggggga tcagaactac
    13021 cagactcaat atggaaatgg taattcccat ggagagctca aaccctggaa tcaccggttt
    13081 atttcttttt ttcataatca attaccacct ctcctgtctc atatattctg tctgtgctta
    13141 tgctcttgct tcatcttgtc ttcctttatc tctcataaat ctgatcgaaa attccgccat
    13201 ctgtgaaatg tttctcctgc actttatccc atccgccata atcactgata tttgccagat
    13261 ttatattcag atcaaacgta tcactgtgct tcttcaggat tttctcatta gtggggcgga
    13321 aataattctc tgctgcgatc tcctgtgctt cgtcggaata cagataattc aaatactcag
    13381 ttgccacatc tcttgtatct ctgtaatcca ccacttcatc taccaccgcc acagaaggct
    13441 gtgccagaat acttacgctt ggagtaacaa tctcatactc atccggataa tcccgcatgg
    13501 atagataagc ttcattttcc cacgcaacca gcacatctcc ttgtccgttc tccacgaaag
    13561 aggtcgttgc acctcttgcg cctgagtcaa gaaccaccac attccggtaa agtttcttga
    13621 taaattcctt catctgcgct tcatcgccac catacttttt atctgcgtaa gcccacgctg
    13681 ccatgtagtt ccatctggca ccgccggagg ttttcggatt tggtgttact actcccactc
    13741 cttttttcgt cagatcgtcc cagtctttga tatccttggg atttcctttc ttcaccagaa
    13801 atacgatagt ggatgtataa ggagaactgt cattgtcaaa tttatctttc catcctgcct
    13861 tgatcagccc tgcgttttca atagactcaa tatcatattc aagtgccagg gttaccacat
    13921 ctgcatccag accattggct acctccagtg cctgtttccc tgaaccgcca tgggactgta
    13981 tcacttccac atcttccccg gtcttctcct tccagtggtc ttcaaatatt ttattatact
    14041 gttcaaacat ctctctggta ggatcatagg aaacattggt gacagacacc gtttttccaa
    14101 aagcctgtac cggcatcagt gccagtacaa ctgcaagacc aaaggcaaat aattttctga
    14161 tcatgtttca tctcctttaa aatgccagta gttttttgca ttctctactt ttcatagtta
    14221 ttctatatgt tttatatgat attacaagaa atgacagaat ttgtcaatag tgtattaaaa
    14281 taagtacaat ttatgttgtg tagataagaa cacaaaaaaa gcagcatcct gaaatacaga
    14341 atgctgcagt caaaattaca tattttttat tcggcagaag ctgctgcctt ttctttctcc
    14401 gggaaaagct ttccgaaaat aaatcttacg aatggtccgg cataaaagat ctgccagaag
    14461 aatgccatcg ggaagttcat tgctgttgtc tggagccatg tgggaatgat ctgacttgcc
    14521 ggtgcatgtt tgatcagcac agttgccgca aagctcatac atggacacat aaatgcaacg
    14581 gatactgctg agattgcaag tacaaggtgg aacggattat ctcttctcat atccacaaca
    14641 ccaaatgcaa tcttctttgc aagaccaccg atgataaaga aatcaagaat aaatgcaatc
    14701 ggtcccatga atgttaattc atgaaaagct aacagaaatg tctcatttgt cattgtccct
    14761 gtgttcagta caatgttgta gcagatcatg gcataaacca ttacaaacac catgataatc
    14821 gtaaaaataa cttcctgaaa cttgttttta ggcataaaaa atcctcctta gatagtatga
    14881 ataacatcaa ttagagattt gtgttgttca taaccatcca ggaggatgta ccgtttccaa
    14941 taataccaaa tatctgtttc ttaaatttac cgttggttat tatacggact gttttaaaaa
    15001 aagtcaagga ttttttcagt acctgcagtg tgaatcaggg aacaaaggtt actgttcaca
    15061 caccactgtc ccgcgaggtg ttttggcatg aatatgccaa aatcccgaga catacaagcc
    15121 aaaattccat tgccgcaggc aatct
//
