LOCUS       gnlProkkaDPPBNJOG_112  17550 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|DPPBNJOG_112.
ACCESSION   gnlProkkaDPPBNJOG_112
VERSION     gnlProkkaDPPBNJOG_112
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2024-12-01 01:14:30
            Original ID  :: gnl|Prokka|DPPBNJOG_112
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 22802
            Orig. end    :: 40352
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..17550
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="True"
                     /core_location="[10000:10734]"
                     /cutoff="20000"
                     /detection_rule="(TIGR04223 or AgrB)"
                     /neighbourhood="10000"
                     /product="cyclic-lactone-autoinducer"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..10734
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(TIGR04223 or AgrB)"
                     /neighbourhood="10000"
                     /product="cyclic-lactone-autoinducer"
                     /protocluster_number="1"
     cand_cluster    1..17550
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(TIGR04223 or AgrB)"
                     /kind="single"
                     /product="cyclic-lactone-autoinducer"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..17550
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="cyclic-lactone-autoinducer"
                     /region_number="1"
                     /rules="(TIGR04223 or AgrB)"
                     /tool="antismash"
     CDS             complement(1847..2074)
                     /locus_tag="ctg112_23"
                     /transl_table=11
                     /translation="MSQSKIKLNATEEVQEFVNAASRCDFDIDVYYNRFLIDAKSILGV
                     LSLDLTRELTVDCHGESREFDRTLKKFAVA"
     CDS             complement(2344..3765)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) GATase_7"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg112_24"
                     /sec_met_domain="GATase_7 (E-value: 3.3e-23, bitscore:
                     73.4, seeds: 307, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAGIKEECGVFGIYDLDGGNVVPSIYYGLTSLQHRGQESCGLAVS
                     DTKGERGNVKFHKDLGLVSEVLRQDVVRKYEGDIGIGHVRYSTTGASVAENAQPLVLSY
                     VKGTLALAHNGNLVNTPELKWELIQNGAIFHTTTDSEVIAFHIARERVHSKTVEEAVLK
                     TAKKIKGAYGLVVMSPRKLIAVRDPYGLKPLCLGKRGNAYVIASESCALTSVSAEFIRD
                     IEPGEILTITKDGLKSNKELASAAAKRAHCVFEYIYFARLDSTIDGVKVYDARIRGGKS
                     LAKSYPVEADLVTGVPESGLPAAKGYSEASGIPFAFAFYKNSYIGRTFIKPTQEERESS
                     VHLKLSVLESVVKDKRIVLVDDSIVRGTTIANLIHMLKEAGAKEVHVRISSPPFLHPCY
                     FGTDVPSNDQLIAASHSTEEICKMIGADSLGYMQTDYLEGMAGGLPLCKACFDGNYPME
                     IPDYTNAEFADIVKC"
     CDS             4182..6281
                     /locus_tag="ctg112_25"
                     /transl_table=11
                     /translation="MAQNIPELYGSLVFNDKVMRSKLPKDMYKALKKTIESGTHLELDV
                     ANSVAVAMKEWATENGATHYTHWFQPMTNVTAEKHDSFISPTGDGQVIMDFSGKELVKG
                     EPDASSFPSGGLRATFEARGYTAWDPTSPAFIKDGTLYIPTAFCSYSGEALDKKTPLLR
                     SMQTLDKEATNLLHIIGNKDIKHVNTTVGPEQEYFLVDKELYKQRKDLVFCGRTLIGAP
                     APKGQEMEDHYFGALKPRVAAYMHDLDVELWKLGIPAKTKHNEVAPAQHELAPVFDTTN
                     VAVDHNQLTMEVMKKVADKHGLVCLLHEKPFEGINGSGKHNNWSMITDTGVNILDPGKT
                     PAENTQFLIFLTAVIKAVDEYADVLRISVASAGNDHRLGANEAPPAVVSVFLGDELTEV
                     LKSIENDEYFAGSRAVQMDIGAKVLPHFVKDNTDRNRTSPFAFTGNKFEFRMLGSEASV
                     ANPNIILNTAVAECVHQFAEQLKDVPEDKMEDAIHELIKKTIIDHKRVIFNGNGYTDEW
                     IEEATKRGLFNLKSTPDALPQWIADKNIELFTKYHIFTKEEIESRYEIWLESYSKILNI
                     ESNTMVEMVQKDFLPSVFAYIDKVAATAVAKKSVVSDVSTASEGKLIKELSQLADEIST
                     GLETLKADTAKALATEDPLTNAKAYQTVVLSDMDELRKSVDAAETLIPDALLPYPTYDK
                     LLFSV"
     CDS             6580..8292
                     /locus_tag="ctg112_26"
                     /transl_table=11
                     /translation="MEFSAVNTIWVLVGAALVFFMQAGFAMVETGFTRAKNAGNIIMKN
                     LMDFCIGTPVFWLVGFGLMFGAGNGFIGKIGGIATEAHYGSGMLPDGVPFWAFLIFQTV
                     FCATSATIVSGAMAERTKFLSYCIYSLMISLVVYPVSGHWIWGGGFISQMGFHDFAGSC
                     AVHMVGGVAALIGAIILGPRIGKYTKDGKSKAIPGHNLTVGALGVFILWFCWFGFNGAS
                     TVSMEGDAIVSAGKIFVTTNLSAAVATVTVMIITWVRYKKPDVSMSLNGSLAGLVAITA
                     GCDTVSPTSAAIIGIASGFIVVFGIEFIDKVLKIDDPVGAVGVHGLNGAFGTLAVGLFS
                     DGSGTDWKGLLTGGGFHGFGVQFTGMIITIAWVVVTMTIIFQVIKHTIGLRVSAEEEIA
                     GLDSKEHGLASAYDGFAMAGVPTPMGTSIKAPVVTARPSAPAESVPELPKEGVHKLTKV
                     VIITRQNKLDEFMQAMNEIGVTGITITNVLGCGVQKGAPSYYRGVEMEMNLLPKVKIEI
                     VVSLVPVQKVIETAKAVLHTGQIGDGKVFVYDIENVVKIRTGEEGYLALQDTK"
     CDS             complement(8475..8621)
                     /locus_tag="ctg112_27"
                     /transl_table=11
                     /translation="MEKRKYKVVIAQSGKLDVKEKRNISFSNLNTGSMQRIFPKRLKSG
                     SCT"
     CDS             complement(8631..8789)
                     /locus_tag="ctg112_28"
                     /transl_table=11
                     /translation="MALAQATKSHEPTYTINDAMDVLLSRLDEAIDDMESDRVQIVEEA
                     WAEIDAI"
     CDS             complement(9257..9406)
                     /locus_tag="ctg112_29"
                     /transl_table=11
                     /translation="MMIWCKKIMGGKDYEVYEKKLICSVFGHKCNSFDKFICNAGACCG
                     KYRN"
     CDS             complement(9403..9786)
                     /locus_tag="ctg112_30"
                     /transl_table=11
                     /translation="MTHKKEVVFSLLFVIMVLCTGCSDKDNGDTSKNNRTSGESFVQEE
                     TIESTDNTDNADGSSAPTPELKTPRTKKELEDALGTVNESGKWTPPAGSHIDPKTGNIL
                     NKDGVVVGTTQEPYSKARPGSQG"
     CDS             complement(10001..10585)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     cyclic-lactone-autoinducer: AgrB"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg112_31"
                     /sec_met_domain="AgrB (E-value: 3e-36, bitscore: 115.9,
                     seeds: 181, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MEKCTDTVVNWMIRCNAINEADKELYKYALYSFFLLVSPLILAGV
                     IGFGLGSVKHGVALIFPFVVLRKFSGGYHAKNLHTCILGSGFLLFLCIMLSMHVQCDLK
                     LAIATVIASVSLITFSPIDSENRRLDTNEKRTYKKTTVFFVILFGLLDIALFLLGKYIY
                     TICFSVGILLTAGLQVPCIVKKMCKSTKNRL"
     CDS             complement(10585..10734)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     cyclic-lactone-autoinducer: TIGR04223"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg112_32"
                     /sec_met_domain="TIGR04223 (E-value: 2.6e-14, bitscore:
                     44.5, seeds: 127, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKKEVTKSVAKGMKAALDVVLRTEANTASCLIMYQPKAPKELMNY
                     RRNK"
     CDS             11030..11359
                     /locus_tag="ctg112_33"
                     /transl_table=11
                     /translation="MGNRIKIRKKELRIKQAELAERLNISNNHMSSIENGRQKPSLDIF
                     IQICNLLNVTPDYLLLGSMHAYNIPQDIIDKLRLCNQSDIELAGDFIELLVKRNNKATH
                     NEPKL"
     CDS             11451..12158
                     /locus_tag="ctg112_34"
                     /transl_table=11
                     /translation="MRILICDDDTLIIEQLKKYIESYFESNHLKCPELVSFTSGEALLT
                     DKGEKDIVFLDIEMPGMNGIYVGNELKKANRNVIVFVVTSYSEYLDEAMRFHVFRYLSK
                     PLDKQRFFRNLKDALAYYNSITLKIPVETKQAVYSFPASQIIAIEAQGRKVIVHTARQD
                     FDSIHNMNYWLEKLPQNSFFQTHRSFIVNFEHIVDFDHSTVHLSNPQITAYLTRRKYSS
                     FRNAYLLYLESMR"
     CDS             12165..13463
                     /locus_tag="ctg112_35"
                     /transl_table=11
                     /translation="MEYIILLIFSFFTEAVILWQYAASLFSPSHSGKKRLTLLSVLYVL
                     LFFLSLLGQTWLNIISFFVINTVFLYIMFNLKLLLALFHSAILTAIMGISELAVLGMIS
                     RFFPHFLLEASVGLVFYTVFSKITFFAVVYLLSWLFKGNKAAQEPYGHSEILLMFIPLS
                     SILMMFTLLSIGETTAYAPPVDFLVTICAVFLLLVNLLVFGINQYNAKRSQEYADLQLL
                     LQKESDSVEYYEMMLAQNENQSILIHDIKKHLQSIRLLNEKNDSDKINDYIQQLMESSD
                     LKETTKLCDHEMLNSILCRYQRHCNDKHIIFHTDIRSGTVQHIYPRDLTSLFCNLLENA
                     VESAENIPDSFIELTVQKKENSPFLIIILINSCQNTPVYNPEGLPISHKSDNGRHGFGI
                     KSIKKVVKQYHGNLQMYYDNDSGTFHTILTLKQ"
     CDS             13954..14466
                     /locus_tag="ctg112_36"
                     /transl_table=11
                     /translation="MRKKLNITEGIFPMPVLMIATYNEDGSINVMNAAWGTMQERDTVA
                     LNLTETHKTVQNIKARGAFTVSIADAAHVTEADYFGVESGNREPDKFARSRLTATKSET
                     VDAPIINNFPPRTKRQSDKLSLTALNITCLILYGILPIHVVTAWADSSGNVLPDIGSAP
                     LQLMILP"
     CDS             complement(14375..15028)
                     /locus_tag="ctg112_37"
                     /transl_table=11
                     /translation="MDYQSIVTFVMEMAGSVAFAASGAMVGVERNMDIFGVSVLGVATA
                     VGGGMIRDIVLGIIPPAVFTNPVYALVSVLASCIVFFIFYFKRELLQGHRRETYDKIML
                     AMDSVGLGIFTVVGVNTGIRQGYMDNVFLLVFLGTITGVGGGLLRDMMASVPPYIFVKH
                     IYACASIIGAVVCVYMNRFVGNVQAMVVSSIVVVLIRYLAAHYRWNLPRLSPHE"
     CDS             complement(15355..15444)
                     /locus_tag="ctg112_38"
                     /transl_table=11
                     /translation="MHPEKKAVSRLNSDALVTQLPSNSLTILC"
     CDS             complement(15476..16321)
                     /locus_tag="ctg112_39"
                     /transl_table=11
                     /translation="MEETYQIHENFLYLENKIFRGMDQIKQLRIYPPEKGNCKIIVVYE
                     VSGQEELPQNGHELSIDLGLHNLMTCYDSGNGKTFILGRKYLALERYFHKEIARVQAQW
                     YGQQSGKGVKYLATSKHIRKLYKRKHDSVTDYLHKVTRYLAEYCREQGITCVVAGDIRN
                     IRREKDLGHRTNQKFHSLPYNRIYIMLEYKLKRYGIRFIKQEESYTSQCSPLSPKVGKR
                     YAEPSKRKERGLYRDGNRTYNADAVGAYNILRKYHSVSGVKRELSVTGLKTPEIIKVAV
                     "
     CDS             16376..16723
                     /locus_tag="ctg112_40"
                     /transl_table=11
                     /translation="MHDPHLHIGNGDTFLLKPRRSGSLDPPGSFQGIKRLPCLVQQLAD
                     FLGRLGRELFIPQILFMGFFLIIPVRMLLYPSFFVMLTLVITDIPELGCCIAHMPDEVR
                     IFPADLYGCFL"
     CDS             complement(16632..16991)
                     /locus_tag="ctg112_41"
                     /transl_table=11
                     /translation="MWGRRPCTLFCVSPSEIIHNCDHEIPEGDLRQETFRTFSGNKKPA
                     LERGAVEPFLLCGNGRICIGRKYPQVHRTSEQSVLILWRRGNAAVKENIHKGQPGICEP
                     HRAYVLCSIQALECL"
     CDS             complement(17391..17549)
                     /locus_tag="ctg112_42"
                     /transl_table=11
                     /translation="MTVYKRNNRTTYTRITGVKPGTYTLKVRPWVKINGRKAYGDWVSW
                     GRRIRVK"
ORIGIN
        1 tacaatatga ttatcagggg aagttcctac gatattcatt cctttctcct gaagttcttt
       61 acggaatgca ttgtttactt cataacgatg tctgtggcgc tcatggattt cttttttgcc
      121 aaagagttca taggatctgg aaccttctgc aagaatacat ggataacttc caagtcttaa
      181 ggttccaccg atatcttcga tatcttcctg atccggcatt aatgcaatta ccggatgctt
      241 tgtctccgga ttcagttcaa tactgtttgc atcttcgtat ccaagtacat gacgggcgaa
      301 ttctacaatt gccatctgca ttcccagaca gattccaaga tatggaatct tatgtactct
      361 tgcatactgt gctgccagga tcattccttc tgtacctctg ttcccgaaac cacccggaac
      421 caggatacca tctacattgt gaagctgctg atccagattc ttctctgtca gttcttcgga
      481 atcgatccag tcaagctcta ccttggctct gcaggaaatt ccgccatgtt tcagtgcctc
      541 tactacactg agatatgcat catgaagctg tgtatatttt cctacaattg cgatctttac
      601 tgttttattc ggatttctca gactttctac catttcctcc cagtcactta aatccggttt
      661 tctgttttcc agacggagac ttgaaagaac tacatctgca agcttctctc tttccattgc
      721 aagaggagct tcatataaat attccacatc caggttctga agtacatgtg atacaggtac
      781 gttgcagaat aaagcgattt tttctttaat gtcctctgtc agctcatgtt cacttctgca
      841 caccagtaca tccggctgaa ttcccattcc ctgaagttcc tttacgcttg cctgtgtagg
      901 ttttgttttc agttcttcag atgcctttaa ataaggaatt aatgttacgt gaatcaggat
      961 tgcattgtca tgtcccacat tgagctggaa ctgacgaatt gcttccagga acggttggct
     1021 ttcaatatca ccaactgttc ctcccacctc gataatggca atcttgtttt cctccggtga
     1081 tttggcgcgg tagaaacgac tcttaatctc atttgtaata tgaggaatta cctgtacggt
     1141 acccccgccg aaatccccgt gacgttcttt ctgaagaaca gaccagtaaa ccttaccggt
     1201 tgtcacattg gaatttttat caagactctc atcaatgaat ctctcataat gtcccagatc
     1261 caggtctgtc tctgtaccat cgtctgttac aaaaacttct ccgtgctgaa tcgggttcat
     1321 ggttccgggg tcgatattga tataaggatc aaacttctgc atggttacct gatatcctct
     1381 cgctttcaga agacgcccca gagatgcagc tgtgattccc tttccaagac cggaaacaac
     1441 tcctcctgta acaaatacgt atttcactgc cattttgatt tcctcctcca tcatcctttg
     1501 ttaataaaaa agcgtcagat gcagctatca gagggcactt gacccatctg gtattctgca
     1561 tctgacgcct ttgtcagatc atcatatctt ctataataat atgttcaatt ggctttcttt
     1621 aaaaatatgc tatactataa aacatttttt ttcgtttgtc aataatgaat ttcccgtttt
     1681 taagcaaaaa caaatcaaat aagttccttc tgataaacta tgaagcagtt atattttatg
     1741 gaattactct gaacacagtc ataatacaga aaaaacgaat ctgtagaagt tcatcttcca
     1801 gacccgtctt ctctgcgata attattcggt tataaaaatg taaaatttat gcaactgcaa
     1861 atttcttcaa tgtacgatca aattcccggc tctccccgtg gcagtctact gtcagttctc
     1921 tggtcagatc cagactaagt acaccaagga ttgatttggc atcaattaaa aatctgttgt
     1981 aataaacatc aatatcaaaa tcacatctgc ttgcagcatt cacaaattcc tgcacctctt
     2041 cggttgcatt taacttgatt ttactctgtg acatcgtgat caccctttct gaaaacattc
     2101 tttgtttttt tctatcagac gcccatatta tgttccacat ttcagaattt gtcaagtttt
     2161 taaatttatc caattttcat aaagcgcagg ggttctattg tgcattttgt tcgtttatat
     2221 atgttttcac agcattattt tatacattat gtatgacttc atcctatatt ggttttacca
     2281 ttatgtgaga ttgattccat atatcatcga caggtttctg cattttttat gaatttttgc
     2341 gacttaacac ttcacaatat ctgcaaactc cgcatttgta taatccggaa tctccatcgg
     2401 ataatttcca tcgaagcatg ccttacataa gggcaggccg cccgccattc cttccagata
     2461 atctgtctgc atgtagccaa gagaatctgc tccgatcatt ttacagattt cctccgtgct
     2521 gtggctggct gcaatgagct gatcatttga cggcacatcc gttccgaaat aacatggatg
     2581 taaaaatggc ggtgaactga tacgtacgtg cacttccttt gctcccgcct cttttaacat
     2641 gtggatcagg tttgcaatgg ttgttccacg aacaatagaa tcatccacca gaacaatcct
     2701 cttatctttt acaacagatt ccagcacact cagtttcaga tgaacgctgg actcacgttc
     2761 ttcctgagtc ggtttgataa atgttcttcc aatatagctg tttttataga acgcaaatgc
     2821 aaacgggatt cctgatgctt cggagtatcc ctttgcagca gggagtccgg actccggtac
     2881 acctgttaca agatctgcct ctacaggata agacttggca agagatttac cgccacggat
     2941 tctggcatca tagaccttca ccccatcaat ggtactgtca agtcttgcaa aatatatata
     3001 ctcaaacaca caatgcgcac gttttgcagc agcagacgca agctctttat ttgacttcag
     3061 tccgtctttt gtgatcgtaa gaatctcacc cggctcaatg tcacggataa attccgcact
     3121 tacagatgtc agagcacagc tctcagaagc aataacataa gcatttcctc ttttaccgag
     3181 acacaatggt ttcagtccat atggatcgcg gactgcgatc agttttctcg ggctcataac
     3241 taccagacca tatgcacctt tgatcttctt tgcagtcttt agcactgcct cttctactgt
     3301 tttagaatgc acacgttctc ttgcgatatg gaacgcaata acctctgaat ctgtagttgt
     3361 atggaaaatc gctccattct ggatcagttc ccatttcagt tccggtgtat taaccagatt
     3421 tccgttatgt gcaagtgcaa gagttccctt tacataagac aaaacaaggg gctgtgcatt
     3481 ctctgcaaca gaagctcctg ttgtggaata tcttacatga ccaataccaa tatccccctc
     3541 atatttacgg acaacatcct gtctgagaac ttcacttaca agtcccagat ccttatgaaa
     3601 cttcacattt ccacgctctc ccttagtatc agaaactgca agtccgcagg attcctgtcc
     3661 tctgtgctgc agggaagtca gtccataata tatggacgga actacattgc cgccatccag
     3721 atcataaatt ccaaagacgc cgcactcttc ttttattcca gccatctgat ttcctccgat
     3781 cgtattctct tgtctgactt taactttact ttcaaaaccc gctgacattg ttttcttatg
     3841 tttggtgggt tccaaaatca aattataata atagaaacaa atttgtcaac ctatcctttt
     3901 tttgccatat ctcaaaaatt ttttctgaat tttttcaaaa aaagtgcttg acatctgttt
     3961 tcatttcgtt tatagtacag cacataaagc aaaggcgctt tggaaagatc tacagagatc
     4021 tcatccaggg cgcctttttc gttttataaa actttcgttt catagaaaat gttcgatgag
     4081 gaattttcta tgagacgaaa accgcaggca gtcacaatgg tgatctgtag cggcactaca
     4141 catattcaga aaatattgca aaccgaaagg agagtaccta tatggcacag aatatccctg
     4201 aactgtacgg cagcctggtc ttcaacgaca aagtaatgag aagtaaactg ccaaaagaca
     4261 tgtacaaagc attaaagaaa acaatcgaga gcggtacaca ccttgaactt gatgttgcca
     4321 actccgttgc tgttgcaatg aaagaatggg ctaccgagaa cggcgccact cattatactc
     4381 actggttcca gccaatgaca aacgtaactg cagagaaaca tgacagcttc atttctccta
     4441 caggagatgg tcaggtgatc atggatttct caggtaaaga acttgtaaaa ggtgagccgg
     4501 atgcttccag tttcccgtca ggcggtcttc gtgccacatt cgaggcaaga ggatatacag
     4561 catgggatcc gacatcaccg gcattcatca aagacggaac cctttacatt cctacagcat
     4621 tctgctccta cagcggagaa gctcttgata aaaagactcc tctccttcgt tccatgcaga
     4681 cacttgataa agaagctaca aaccttctcc atataatagg aaataaagat atcaaacacg
     4741 taaatacaac tgtaggtcct gaacaggaat acttcctggt agacaaggaa ttatacaaac
     4801 agagaaaaga tcttgtattc tgcggacgta cactgatcgg tgctcctgct cctaagggcc
     4861 aggaaatgga agatcattac ttcggtgctc tgaaacctcg tgtcgcagct tatatgcatg
     4921 acctggatgt agagctctgg aaacttggta ttcctgccaa aacaaaacat aacgaagttg
     4981 ctcctgcaca gcacgagctg gctcctgtat tcgatacaac aaacgttgcg gttgaccaca
     5041 accagttaac aatggaagta atgaagaaag ttgccgacaa gcacggactt gtatgccttc
     5101 ttcacgagaa accatttgag ggaatcaacg gaagtggtaa acacaacaac tggtctatga
     5161 ttacagatac tggtgtaaat atccttgatc cgggaaaaac acctgctgaa aatacacagt
     5221 tcctgatttt cctgacagct gttatcaaag cagttgatga atacgcagat gtacttcgta
     5281 tttctgtagc aagtgcagga aatgatcacc gtcttggtgc aaacgaggct ccgcctgctg
     5341 ttgtatccgt attcctcggt gatgaactga cagaagtatt aaaatctatc gaaaatgacg
     5401 aatattttgc aggaagccgc gcagtccaga tggatatcgg tgcaaaagta cttccacatt
     5461 tcgtaaaaga caatacagac agaaaccgta cttcaccatt cgcatttaca ggtaacaaat
     5521 tcgaattccg tatgcttggt tccgaagctt ctgttgcaaa cccgaacatt atcttaaaca
     5581 ctgctgttgc tgagtgtgtt caccagtttg cagaacagtt aaaggatgta ccggaagaca
     5641 agatggagga tgcaatccac gaactgatca agaagacaat tattgatcat aaacgtgtta
     5701 tctttaacgg aaacggttat acagacgaat ggattgaaga agctacgaaa cgtggtctct
     5761 ttaacctgaa atccacaccg gatgctcttc ctcagtggat cgcagacaag aatattgaac
     5821 tctttaccaa atatcatatc ttcacaaaag aagaaattga atcccgttat gagatctggc
     5881 tggaatccta ttccaagatt cttaacattg agtccaatac tatggttgaa atggtacaga
     5941 aggatttcct tccatctgta ttcgcgtata tcgacaaagt tgcagctact gctgttgcta
     6001 aaaaatcagt tgtttcagat gtcagcacag cttctgaagg aaaactgatc aaagagctgt
     6061 cacagcttgc tgatgagatt tccacaggtc ttgagacctt aaaagcagat actgccaaag
     6121 cgcttgctac agaagatcct ctgactaatg caaaagcata ccagacagtt gttctttctg
     6181 atatggatga actcagaaag tctgtagatg cagcagaaac tctgattccg gatgcactgc
     6241 ttccatatcc tacatatgac aagcttctgt tttccgttta attaacaggt aataacaggg
     6301 gaatatcttt atgaactcta cttcataatt cattatcgat ttcctcatcc attaatcaca
     6361 cgatattttg atgttcccct gttttacata taattttgat tttaaactgc attgcataca
     6421 gtcatacgaa atgtcttttc tattacatca gttatgcaat acactataaa tatggatttt
     6481 atattcgcaa aagcgcgatg aactggctac atttccaggc atcgcgcttt ttgcatttta
     6541 taaaatatga ggaaattttt atgagggagg aatattatta tggaattttc cgcagtaaac
     6601 acaatatggg tgctggtcgg cgccgcgctg gtcttcttta tgcaggccgg attcgcaatg
     6661 gtagaaacag gcttcacacg agccaaaaac gcaggtaaca ttattatgaa aaacctgatg
     6721 gacttctgta tcggaacccc ggtcttctgg ctggtcggct tcggtctgat gttcggtgca
     6781 ggtaatggat ttatcggaaa gatcggtggt attgcaacag aagcacacta tggttcagga
     6841 atgcttcctg acggagttcc tttctgggca ttcttaatct tccagacagt attctgtgca
     6901 acatccgcaa caattgtttc cggtgcaatg gcagaacgta ccaagttcct ttcctattgc
     6961 atctacagcc ttatgatcag tcttgttgta tatccggtat ccggacactg gatctggggc
     7021 ggtggattta tcagccagat gggattccac gatttcgcag gttcctgtgc agtacatatg
     7081 gtaggtggtg tggcagctct gatcggtgcc atcatccttg gacctcgtat cggtaaatat
     7141 acaaaggacg gcaaatcaaa ggctatcccg ggacacaacc ttacagttgg cgctttaggt
     7201 gtatttatcc tctggttctg ctggttcgga tttaacggtg cttccacagt aagtatggaa
     7261 ggcgatgcaa tcgtaagtgc cggtaaaatc ttcgttacta ctaacctttc agcagctgtt
     7321 gcaactgtaa ctgttatgat catcacatgg gtacgttaca aaaaaccgga tgtttccatg
     7381 tctctgaacg gttctcttgc aggacttgta gcaattacag caggatgcga cacagtttct
     7441 cctacatccg cagcaatcat cggtattgct tccggtttta tcgtagtatt tggtattgaa
     7501 tttattgata aggttctgaa aatcgatgat cctgttggtg ctgtcggtgt tcatggttta
     7561 aacggtgctt tcggtaccct tgcagttggt ctcttctccg acggttcagg cacagactgg
     7621 aaaggacttc ttacaggcgg cggcttccac ggatttggtg ttcagttcac aggtatgatc
     7681 atcacaatcg catgggttgt tgttactatg acaattatct tccaggtaat caaacataca
     7741 atcggacttc gtgtttcagc tgaagaagag atcgcaggtc ttgactccaa agaacatggt
     7801 cttgcaagtg cttatgacgg tttcgcaatg gctggtgttc cgactcctat gggaacttcc
     7861 ataaaagctc ctgttgtcac agccagacct tctgctcctg ctgaatcagt tcctgaactt
     7921 ccgaaagaag gcgttcataa gcttacaaaa gttgttatca tcacccgtca gaataagctt
     7981 gatgaattta tgcaggcaat gaatgagatc ggtgttacag gtatcactat tacgaacgtt
     8041 ctcggatgcg gtgtacagaa aggtgctcca tcctactatc gtggtgttga gatggaaatg
     8101 aatcttcttc ctaaggtcaa aattgagatt gttgtaagtc tcgtacctgt acagaaagtt
     8161 atcgaaactg ccaaggcagt cctccatacc ggtcagattg gtgatggtaa agtatttgta
     8221 tatgacattg aaaatgtcgt taagatccgt acaggcgaag aaggttatct cgcactgcag
     8281 gatacaaagt aaattattta tcaacaatca ggtaatatta ataagagaca tcagcgtatt
     8341 gattgctggt gtctcttatt ttaatctttc tttctaacaa ttccaatggc gttaaaaaac
     8401 aggcagtata tttcatgtaa atatcatagc cacgatatcg gaagcctatt gtattatatc
     8461 tggtaggaag tgtgtcaagt gcaagaaccg ctttttaatc ttttgggaaa aatcctctgc
     8521 atactcccgg tatttaaatt gctgaaggat atatttcttt tttccttcac atccagcttg
     8581 ccgctctggg caattacaac tttgtatttt cttttttcca tccgtacccc ttatattgca
     8641 tcaatttctg cccatgcttc ttccactatc tgcactctgt cactttccat atcatcaatg
     8701 gcttcatcca gccttgacaa aagaacatcc attgcatcat tgattgtata agttggttca
     8761 tgggattttg ttgcctgtgc caatgccata accatcaccc tttcttgaaa tagcactttt
     8821 gtttctattt ttatcatacc acgaaccacc ggaaatatct atatatttta aatttgtctt
     8881 tataacccaa acacagaata ctgtttttgg gacgtttttt agaatttgtc catttgtagt
     8941 ttcaattaaa aaagtaaata aaagtgctgc cgcaccaaac ttttcagtgc ggcagcccat
     9001 acagctattt acctatgcct cgtttatatt aaatgttttt ccttaaagct cccgaaggta
     9061 atcggcacta acataacggt aaatgccgcc aagagaaatt ttggcccacc cattactgat
     9121 agaatataca tatacttttg tgccataatt caatgtgcct actattgtat attgtgttcc
     9181 agggcctgat ctgatattta catccgaccc tgtgcacttg taatatcccg gtacgcttct
     9241 cgtgacagag tttgtttcaa ttcctgtatt ttccgcagca agcaccggca ttgcaaatga
     9301 acttgtcaaa agaattgcac ttatgaccaa acacactaca aatgagtttt ttctcatata
     9361 cttcataatc ttttcctccc ataatttttt tacaccatat catcatcctt gagaacctgg
     9421 acgtgcttta ctataaggtt cctgcgtagt tccaaccacg accccatctt tattcagtat
     9481 attacctgtt ttgggatcta tatgagaacc ggctggtggc gtccattttc ccgactcatt
     9541 cactgtacca agcgcatctt ccaattcctt tttcgttcgg ggcgttttca gttctggcgt
     9601 tggtgccgag ctgccgtctg cattgtctgt attgtcagta ctctcaatag tttcttcttg
     9661 aacaaatgat tctcctgaag tcctgttatt tttagacgta tctccattat ctttatcact
     9721 gcagcctgta cataacacca ttattacaaa caacaagcta aaaacaactt ctttcttatg
     9781 tgtcatttta atcttttacc tccattatgc ccgtttaact actccgaacc gaactactca
     9841 atttaaagtg atagaattct atcattgtcc cattggaatc cactcccttt caatgaacaa
     9901 actgaattaa ctgtaaataa agaactttga tcaaatcaat gacaaacttt attatcttta
     9961 tttttgccat gatttcaacc ccttttgcac caaacgacat ttacagtctg tttttggtcg
    10021 atttacacat tttctttacg atacaaggta cttgtaagcc tgctgtcagt aatatcccaa
    10081 cagaaaaaca gattgtatag atgtactttc ccagcaaaaa taaagctata tctaacagcc
    10141 caaacagtat cacgaagaac actgttgttt ttttatatgt ccttttctcg ttagtatcaa
    10201 gtcttctgtt ttcactgtct attggactaa atgtaatcag gctcacagac gcaataactg
    10261 tagctattgc caacttcaaa tcacattgca catgcattga taacattatg cacagaaaca
    10321 atagaaaacc agatccaaga atacaagtgt gcaaattttt tgcatgataa ccaccactaa
    10381 attttctcag aaccacaaac ggaaaaataa gagcaactcc gtgttttacg cttcccaagc
    10441 caaagccaat aactcctgca aggataagtg gtgataccaa tagaaaaaaa ctatataatg
    10501 catacttgta aagttcctta tccgcctcgt ttatcgcatt acaccggatc atccaattta
    10561 ctactgtatc tgtacatttt tccattactt gtttctcctg tagttcatta attctttcgg
    10621 tgccttaggc tgatacatga taagacaaga agctgtgtta gcttctgtcc gtaacacaac
    10681 atctaatgct gctttcattc cttttgcaac cgatttagtt acctctttct tcataatgac
    10741 ctctctcctt tccactaaaa tttgtcattg attttcacat aagcaatcat ataccacttt
    10801 aatcaaataa acgacccctt tggaatgaac ggaatgattc tttacaatat tggataattt
    10861 ccctcttttc tacgaaaaat aatatgtgat acagaattat ttatatataa atatcagttt
    10921 gtttaatata ttgcagaata gttctttgtt acattcttct ttttatttag ttctattggt
    10981 aaaattctac tgaaagaagg tgggataaat agaatttcaa tatgaaggta tgggaaaccg
    11041 catcaaaata cgcaaaaaag aattacggat aaaacaggca gaacttgccg aaagattaaa
    11101 tatatccaat aaccatatgt catcaatcga aaacggaagg caaaaaccaa gtctggatat
    11161 tttcattcag atttgtaatt tactcaatgt tacacctgac taccttctgc tcggcagtat
    11221 gcacgcttat aatattccac aggatattat tgataaacta cggttatgta atcaatccga
    11281 catagagctt gccggagact ttatcgaact gcttgtaaaa cgaaataaca aagcaacaca
    11341 taatgaacca aaattgtaat taaattgtct tttcatacgc attttttgca tttggaaatt
    11401 ctatgtgata agatgtacac atacatctat ttagaaagtc aggtgaaaaa atgcgtattt
    11461 taatttgtga tgatgacact ctgatcattg aacaattgaa gaagtatatc gaatcctact
    11521 ttgagtccaa ccatttaaaa tgtcctgaat tagtttcttt taccagtggt gaagctttgt
    11581 taactgacaa aggtgaaaag gatattgttt ttctggatat cgaaatgcct ggcatgaatg
    11641 gaatctatgt tgggaatgaa ttaaaaaaag caaatagaaa tgtgatcgtt tttgttgtca
    11701 cctcttattc tgaatatttg gatgaagcaa tgcgttttca tgtattccgt tacctttcca
    11761 aacctctaga taagcagcgt tttttccgaa atctgaagga tgccttagct tattacaatt
    11821 ccattacact caaaattcct gtggaaacaa aacaggcggt atattcgttt cctgcttcgc
    11881 agattattgc catagaagct caggggcgaa aagtaattgt acatactgcc cgtcaggact
    11941 ttgactctat tcataatatg aattactggt tggaaaagct tccccaaaac agtttttttc
    12001 agacacaccg gagctttatt gttaacttcg aacatattgt ggactttgat cactccaccg
    12061 tacatttatc aaatcctcag attaccgctt acctgacacg caggaaatac agttccttca
    12121 gaaatgcata tctactatat ctggaaagca tgaggtgaaa ataaatggaa tatattattt
    12181 tacttatttt tagttttttt acagaagcgg ttatcttatg gcagtacgcc gccagccttt
    12241 tttccccttc tcatagcggt aaaaagagac tgactctatt aagtgttctt tatgtactgt
    12301 tgttttttct ttccctgctt gggcaaacat ggctgaatat tatcagtttt tttgtgataa
    12361 acactgtttt cctctatata atgtttaacc tcaagttatt attggcactc ttccattccg
    12421 ctatacttac agcgattatg ggaatatctg aacttgcagt tttggggatg atatcaagat
    12481 tctttcccca ttttctctta gaagcaagtg tcggacttgt tttttatacc gtatttagca
    12541 aaattacctt ttttgcagtc gtttacttgt taagttggct cttcaagggg aacaaagcag
    12601 ctcaagaacc gtacggtcac tccgaaattc tcttgatgtt catcccgctt tcctctattc
    12661 ttatgatgtt tactcttctt tctattggtg aaacaaccgc atatgcccca ccggttgatt
    12721 ttctagtaac aatctgtgcc gtttttctgt tgctggtcaa cctacttgta tttggaatca
    12781 accaatataa cgcaaaaaga tcacaggaat atgccgattt gcagttactg ctccagaaag
    12841 aatccgattc tgttgaatac tatgaaatga tgcttgcaca aaacgagaac cagagcattt
    12901 tgatccacga tataaagaaa catcttcaat caatcagatt actgaacgaa aaaaatgatt
    12961 ccgataaaat aaatgactat atacaacaac tcatggaatc ttccgactta aaggaaacca
    13021 caaaactctg tgatcatgaa atgctaaact ccattctgtg ccgctatcag cgccactgca
    13081 atgataagca cattattttt cacactgaca tcagaagcgg cacggtacaa catatatatc
    13141 cgcgcgattt gacttcttta ttctgtaact tattggagaa tgcagtggaa tcagcagaga
    13201 atattccaga ctcttttatt gagctcaccg tacaaaagaa agaaaattca ccctttctta
    13261 ttatcatact catcaactcc tgccaaaata cccctgtata taatccagag ggacttccta
    13321 tatcccataa atcagacaat ggcagacatg gattcggaat caaaagcatt aaaaaagtcg
    13381 taaaacagta ccatggaaat ttgcaaatgt attatgataa tgattccggt accttccata
    13441 caatcctaac cttaaagcag taaatattaa aatctggcaa tcgcaatttt atacgattgc
    13501 ctttttacat atttcagcat gcattgatgt tgttttatat cactataaat gagcaagttc
    13561 gtgattttgc ataaaagaaa gagatctttt cctgttatgt gtgtcgatgg ccgatcgaga
    13621 tatttttcag gcaatgtaaa aaccgtctgg cactggatac ataccagatc cgtttctcaa
    13681 aggaaataca gagatactgg ctgctgatgt cactggcaca ttgtatttgt gtcacaggaa
    13741 ctggcaaata tcgatctttt caagatggat atcatcgaat ctgtagtgcc gttcatcagg
    13801 aaaagtatca gtatctattc ctatgtgcaa aagcaagtga tgattttgaa gcatttatga
    13861 aattagcagg ataattttgt gcattttttc aaacttgctc atttatagca ggatatatta
    13921 tcctgtcaat tgaatctgaa aggggctgtt gtaatgagaa aaaaattaaa tattacagaa
    13981 ggcatttttc ctatgcctgt attgatgatt gcaacctata atgaagacgg aagcatcaat
    14041 gtaatgaacg ctgcctgggg tacgatgcag gaacgtgaca cagttgcatt gaaccttacc
    14101 gagacccata aaaccgtaca gaatatcaaa gcacgcggtg catttaccgt cagcatcgcg
    14161 gatgccgcac atgtaacaga agctgactat ttcggtgtag aatccggtaa tcgcgagcct
    14221 gataaatttg cccgcagccg tctgaccgcc acaaaatctg aaactgtaga tgctccgatt
    14281 atcaataatt ttcctcctcg aacgaaaaga cagtcagaca aactcagcct gactgcgcta
    14341 aatattacct gtctgatttt atacggtatc cttcctattc atgtggtgac agcctgggca
    14401 gattccagcg gtaatgtgct gccagatatc ggatcagcac cactacaatt gatgatacta
    14461 ccatagcctg tacatttccc acaaatcgat tcatatatac gcatacaact gcaccaatga
    14521 tggaggcaca ggcatagata tgttttacaa aaatatacgg cggtacactc gccatcatat
    14581 ctctaagcag accgccgcct actcccgtaa tggttccaag aaatacaagc aggaacacat
    14641 tgtccatata tccctggcgg attcctgtat ttactcctac tactgtaaaa atcccaagcc
    14701 cgacagagtc cattgccagc atgattttat cgtaggtctc acgcctgtgc ccctgaagca
    14761 attctctctt gaaataaaaa ataaagaaaa caatgcagga agcaagcact gacaccagtg
    14821 catatacagg attggtaaat acagccggag ggatgatccc cagaacaata tccctgatca
    14881 ttcctccgcc tactgctgtt gcaactccca gaacgctcac gccgaaaata tccatattcc
    14941 gttcaacgcc caccatcgct ccggaagcag caaacgccac tgaaccggcc atttccataa
    15001 caaatgttac aattgactga taatccatat ttgtttttta actccccatc ctatctttct
    15061 tttataatcc cagaaaacaa tgcaactaat gcactcctgc aaagcacgaa agacaggaaa
    15121 atgctgaact gtcttaattg cattattttc tggaattgct ataaaaatat cagtaaatct
    15181 ccgttcatca cttaatgttt tcataattga agcaggagat tccactgaat tatccaagat
    15241 aaaaagtcga ttttttgaac gtcacgtgaa agagtcttta ctctcaatca gtatcagaaa
    15301 atcgactatt tattccattt catatagata aacttatata cttcgcgaac accttcagca
    15361 tagtatagta agtgaattac tcggcaactg agttaccaga gcatctgaat taaggcggga
    15421 taccgccttt ttttcagggt gcatccatga caccactact gtttgctctt tagagctata
    15481 cagctacttt tattatttcc ggtgtcttca gtccggttac ggacagttct ctttttactc
    15541 cggatacgga gtgatatttt ctcaggatat tatatgcgcc tacggcatct gcgttatagg
    15601 ttctgtttcc atctctatac aatcctctct ctttccgttt ggacggctct gcatatcttt
    15661 tccccacttt cggtgacagc ggactgcact ggctggtata actttcttcc tgttttataa
    15721 aacggatccc atatcttttc agcttatatt ccagcatgat gtagatcctg ttatacggca
    15781 gactgtggaa cttctggttt gtcctgtgtc ccaggtcttt ttctctccgg atattccgga
    15841 tatcccctgc aacgacacag gtgatcccct gttcccggca gtattctgca agataccttg
    15901 tgaccttgtg cagataatcc gttactgaat catgttttct cttatataac ttcctgatat
    15961 gttttgatgt agccagatac tttactccct ttccggactg ctgcccatac cactgggcct
    16021 gcacccttgc gatctcttta tggaaatatc tttccagtgc aaggtacttc ctgcccaaga
    16081 taaacgtctt accgttcccg gaatcataac acgtcataag attatggagt cccagatcaa
    16141 tggacagttc atgtccgttc tgtggaagtt cttcctggcc agaaacctca taaacaacaa
    16201 taattttaca gtttcccttc tccggcggat agatccgcag ctgtttgatc tgatccatgc
    16261 ccctgaaaat cttattttca aggtaaagaa agttttcatg gatctgatac gtttcttcca
    16321 tatatttttt taatgccttt ggaagggaca ggcggactct gcccgtatcc cgctcatgca
    16381 cgatccccat ctgcatatag gtaatgggga tactttcctg cttaaaccgc ggcggtctgg
    16441 gagtctcgat ccccccggat cttttcaggg cataaaaaga cttccatgcc ttgtccagca
    16501 gcttgcagac ttcctgggcc gtctgggacg ggagctgttt ataccacaga tcctctttat
    16561 gggctttttt ctgataatac cagtccggat gctgctctat cccagtttct ttgtaatgct
    16621 gacgctcgta attacagaca ttccagagct tggatgctgc atagcacata tgcccgatga
    16681 ggttcgcata ttcccggctg acctttatgg atgttttctt tgacagcagc atttcctctc
    16741 ctccatagta tcagtacgct ttgctctgat gttcgatgta cctgcggata ttttcttccg
    16801 atacagatcc gaccatttcc acataatagg aatggttcca cagctcccct ttccaaagct
    16861 ggtttcttat ttccggaaaa cgttcgaaaa gtttcctgcc ggagatcccc ttcaggtatt
    16921 tcatgatcgc agttatggat aatttcggag gggctgacac aaaacagtgt acatggtctc
    16981 cttccccaca ttcaaacaga tggaccgtaa agcccttatc ttctgcgatc tcctgcacca
    17041 gtttctgcag atatgcctcg acctccgcac ttaatatctt ccgccggtat tttaccgacc
    17101 ataccatatg gtaattaata ttgcacacac aagtgcgata atgtataaga ttttctttca
    17161 tacatatatg ataccatgat atcaaaaatt tcgcaataag atatcgaaca tattttcttt
    17221 tttatgatgc tggatacagc tttttatagg gagaaattga atgaaaaccg ttttgttatt
    17281 tttatttatt atgagtgcag atatgcacag tttgcgcttt catctcggta attgaattgc
    17341 cgaggattcc cgcttattat cctaaacaag gggcagttgt ctgtttcttt ttattttacc
    17401 ctgattcttc ttccccagga tacccagtct ccgtaagctt tccttccgtt aattttgacc
    17461 catgggcgga ctttcagagt ataggttccg ggcttcacgc ctgtaatcct tgtataggtt
    17521 gtccgattgt tccgtttata tacggtggtt
//
