LOCUS       gnlProkkaMDLEHPFK_113  11925 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|MDLEHPFK_113.
ACCESSION   gnlProkkaMDLEHPFK_113
VERSION     gnlProkkaMDLEHPFK_113
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2024-11-17 05:12:56
            Original ID  :: gnl|Prokka|MDLEHPFK_113
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 28202
            Orig. end    :: 40127
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..11925
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="True"
                     /core_location="[10000:11589]"
                     /cutoff="20000"
                     /detection_rule="(TIGR03973 or SCIFF or (cds(PF04055 and
                     (TIGR04085 or SPASM)) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]) and not (TIGR01716
                     or subtilosin or TIGR02111 or TIGR03966 or TIGR04103 or
                     (YcaO or TIGR03604))))"
                     /neighbourhood="10000"
                     /product="ranthipeptide"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..11589
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(TIGR03973 or SCIFF or (cds(PF04055 and
                     (TIGR04085 or SPASM)) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]) and not (TIGR01716
                     or subtilosin or TIGR02111 or TIGR03966 or TIGR04103 or
                     (YcaO or TIGR03604))))"
                     /neighbourhood="10000"
                     /product="ranthipeptide"
                     /protocluster_number="1"
     cand_cluster    1..11925
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(TIGR03973 or SCIFF or (cds(PF04055 and
                     (TIGR04085 or SPASM)) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]) and not (TIGR01716
                     or subtilosin or TIGR02111 or TIGR03966 or TIGR04103 or
                     (YcaO or TIGR03604))))"
                     /kind="single"
                     /product="ranthipeptide"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..11925
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="ranthipeptide"
                     /region_number="1"
                     /rules="(TIGR03973 or SCIFF or (cds(PF04055 and (TIGR04085
                     or SPASM)) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]) and not (TIGR01716
                     or subtilosin or TIGR02111 or TIGR03966 or TIGR04103 or
                     (YcaO or TIGR03604))))"
                     /tool="antismash"
     CDS             complement(446..1960)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF04055"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg113_28"
                     /sec_met_domain="PF04055 (E-value: 1.4e-24, bitscore: 78.5,
                     seeds: 518, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MCKIGILFKNRDFEHDVYELIKAFYPEAEIHTLYENGEAEYDLRF
                     SVERDNDSYIIKYERTENLSKQETEQKGVISADILSKENAGCGIQDAHALRKENKDNIK
                     YALYQLLVKLTGRTLPWGNLTGIRPAKLAMGMIESGMKNTEAAREMRERYLVSPQKTAL
                     AITIANREREILKDIDYENGYSLYIGIPFCPSICLYCSFSSYPLKVWEKRTDEYVEALC
                     REVRETALMMKGRKLDTIYIGGGTPTTLLPHQIRKLLDTVGEAFGYEGLAEFTVEAGRP
                     DSITREKLMAIREYPVTRISVNPQTMNQETLDIIGRRHTVEQTKEAFHLARELGYDNIN
                     MDLIVGLPGEDIHMVERTLEQVRELAPDSITVHSLAVKRAARLNIFKEKYQEMSFENNQ
                     EIMDLTMKTAYEMGMGPYYLYRQKNMKGNFENVGYAKVDKAGIYNILIMEEKQPIIALG
                     AGGSSKLVFDHGQRIERVENVKDVSNYISRIDEMIERKRTAIATWL"
     CDS             complement(1953..2582)
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1170:metallo-beta-lactamase family protein (Score:
                     164.5; E-value: 3.5e-50)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg113_29"
                     /transl_table=11
                     /translation="MKNLELQKCILGPVYTNCYLLKNKETGELIIVDPADCLEKIEMKI
                     SRMNGKPVAILLTHGHFDHILAAQAVKEKYNIPIYACRQEEEMLREPSINMTVHYGQGC
                     SIVPDVFLEDLDVIRLAGFSVQMIHTPGHTKGSCCYYLKDEGVLFSGDTVFYGSVGRTD
                     FPGGSTAEIVRSLHKLVDSLPEETEVFPGHDASTTIGYEKRYNPFV"
     CDS             complement(2647..4977)
                     /locus_tag="ctg113_30"
                     /transl_table=11
                     /translation="MTEITKSTEAKKDEMQVEKEKLESVKRADAAVKTMHDFTSPEVLY
                     KELINSVLKYHPSTDISMIEKAYKVASEAHEGQKRKSGEPYIIHPLCVAIILADLELDK
                     ETIVAGLLHDAVEDTWMTYEEVEKEFGSEVALLVDGVTKLGQLSYSADKVEVQAENLRK
                     MFLAMAKDIRVILIKLADRLHNMRTLQYMRPEKQQEKARETMDIYAPIAMRLGISKIKV
                     ELDDLSLKYLKPDVYYDLVHKVALRKSEREQFVGAIVKEVKKHMDDANIKAQVDGRVKH
                     FFSIYKKMVNQDKTIDQIYDLFAVRILVDTVKDCYAALGVIHEMYKPIPGRFKDYIAMP
                     KPNMYQSLHTTLIGPNGQPFEIQIRTYEMHRTAEYGIAAHWKYKESSDGKAPVGKSEEE
                     KLNWLRQILEWQRDMSDNKEFMSLLKNDLDLFADSVYCFTPQGDVKTLPSGSTPVDFAY
                     SVHSAVGNKMVGARVNGKLVPIEYEIKNGDRIEIITSQNSQGPSRDWLKLVKSTQAKNK
                     INQWFKKELKEDNILKGKEMLAQYARAKGFKIANYTKTQYLEAVLRKYGFRDWDSVLAA
                     IGHGGLKEGQVFNKLVEAYDKENKKNLTDEQVLEAASETQEKLHIAKSKSGIVVKGIHD
                     VAVRFSKCCNPIPGDEIVGFVTRGRGITIHRTDCVNVLNMSETDRTRLIEAEWQQPDTK
                     EKEKYMAEIQVYANNRTGLLVDLSKIFTERKIDLRSINSRTSKQEKATISMSFEIGSKE
                     ELRSLIEKIRQVESVIDVERTTG"
     CDS             complement(5015..5539)
                     /locus_tag="ctg113_31"
                     /transl_table=11
                     /translation="MKKIEDYVLSIPDFPEPGIIFRDITSVLQDADGLQLAIDSMQDCL
                     KDIDVDVIAGTESRGFIFGVPIAYNLHKPFVPIRKKGKLPRETVSVSYDLEYGSAEIEM
                     HKDSIKPGQKVVIVDDLIATGGTIEAAIKLVEQLGGEVVKVVFLMELAGLKGRERLNGY
                     DVASVICYDGK"
     CDS             complement(5687..7399)
                     /locus_tag="ctg113_32"
                     /transl_table=11
                     /translation="MEKWVIAAKRADFNQIGQQFHIDPVIARLIRNRDVIGEDKIREYL
                     SGTVQELPSPWLMKDMEKAVDILEKKISQKAKVRIIGDYDIDGVTSTYILMKGLARIGA
                     DVDTYIPDRVADGYGIHAHLIERAETDRIDTIVTCDNGIAAAAEIQMAKDKGMTVIITD
                     HHEVPYREEKGERQMVLPPADAILNPKQYDCPYPNKNLCGAVVAFKYIAALYERFGVPA
                     EELEDYYELAAIATVGDVMDLQGENRILVKEGLCRLKNTKNQGLQELIRANSLEDAKIT
                     AYHIGFVLGPCINASGRLDTAARSLALLNAKTKEEAARLAGDLTALNQSRKALTEKGKE
                     EAIRIIETTELKNDRVLVVYLPDCHESLAGIIAGRIREKYHRPAFVLTGGETSAKGSGR
                     SIESYSMYEELVKCADLMIQFGGHPMAAGLSIEEKNIEEFRRRLNVNCTLTDEELRPKI
                     VIDVPMPVSYITKELVEQISLLEPFGKGNTKPVFAQKNLRVLDHSIIGKNKNVVKLKLL
                     DPQGISVEGIYFGEAEDFVNFIREKDSISVTYYPEINRFRGRESLQIIIQNYC"
     CDS             complement(7481..9889)
                     /locus_tag="ctg113_33"
                     /transl_table=11
                     /translation="MKKSKGIVVLLLTLILTVFFCFTAAVGIGPTGTGAAKHINTGLDL
                     AGGVSITYQAKESNPTSEEMSDTIYKLQKRVEQYSTEAQVYQEGSDRITVEIPGVTDAD
                     TILNDLGKPGSLYFITKEDADGNQNFTTGQDGYVLSRTMDEIKESGSVVLEGSDVADAQ
                     GGAIQNQNTSAKEYVVSLTLTSDGENSGKTKFAEATKNNVGKQIAIVYDNNIISAPNVN
                     EEISGGKAQISGMSDLEEAQNLASYIRIGSLGLELEELRSSVVAAQLGEEAISTSVLAG
                     AIGLIIVIIFMIIAYRVPGVVAGIALILYTSLMLITLNAFDITLTLPGIAGIILGIGMA
                     VDANVIIYARIREEIGAGVSVRNSIKSGFSKAFSAIFDGNITTLIAAFVLMWLGSGTVK
                     GFAYTLALGIVISMFTALVVSRLIVNALYAVGVRDPKFYGSAKERKAVDFLGKKKVFFA
                     ISIILILCGPAAMFANSHAGNKALNYSLEFSGGTSTTVTFNEDMDIKTIDSEVTPVVEE
                     VTGDKNVQPTKVVGTNQVVIKTRSLNQSEREALQSALVEKFGVDDSTISTESISSTVSS
                     EMRRDAIVAVIVATICMLLYIWFRFKDIRFASSAVLALLHDVLVVLAFYAIARVSVGNT
                     FIACMLTIVGYSINATIVIFDRIRENLHSGSREKLAEIVNTSITQTLTRSIYTSFTTFV
                     MVAVLYIMGVSSIREFAAPLMVGVLVGAYSSVCITGALWYVMKKKFAGKGQPAIAAASA
                     SAKSSSKPKKARDVSQKDPTQPKKKNRKRVAERLAAEEAAKKQQNDDAE"
     CDS             complement(10001..11368)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     ranthipeptide: TIGR04085"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     ranthipeptide: PF04055"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     ranthipeptide: Ranthipeptide_rSAM_RRE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_12"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg113_34"
                     /sec_met_domain="Ranthipeptide_rSAM_RRE (E-value: 4e-29,
                     bitscore: 92.0, seeds: 20, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_12 (E-value: 2.7e-16, bitscore: 51.3,
                     seeds: 84, tool: rule-based-clusters)"
                     /sec_met_domain="PF04055 (E-value: 2.4e-14, bitscore: 45.3,
                     seeds: 518, tool: rule-based-clusters)"
                     /sec_met_domain="TIGR04085 (E-value: 6.1e-20, bitscore:
                     62.7, seeds: 281, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSLIHRYKSNGFNIVLDINSGCIHLVDEVTYEVLPYLEEGLGTEA
                     IAEKLENKYNREDIETSVRECNKLKEDGMLFTKDVYENVIEEFSNNRQTVVKALCLHIA
                     HDCNLACRYCFAEEGEYHGRRALMSYEVGKKALDFLIANSGSRKNLEVDFFGGEPLMNW
                     QVVKDLVKYGREQEKLHNKKFRFTLTTNGVLLNDEVMEFCNKEMGNVVLSVDGRKEVHD
                     YMRPFRKGAGSYDLIMPKFQKFAESRNQDKYYVRGTFTHHNLDFSKDVLHLADLGFKQI
                     SVEPVVAADTEEYAIREEDIPQIMEEYDTLAKEMIKREKEGKGFNFFHFMIDLTGGPCV
                     YKRLSGCGSGTEYLAVTPWGDFYPCHQFVGEEQYLMGNVDEGITKPEIQKEFGGCNVYT
                     KKDCKDCFARFYCSGGCAANAFHFQGDIKGNYEIGCELQRKRVECAIMIKAALACD"
     CDS             complement(11449..11589)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     ranthipeptide: SCIFF"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     ranthipeptide: TIGR03973"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg113_35"
                     /sec_met_domain="TIGR03973 (E-value: 8.2e-28, bitscore:
                     87.3, seeds: 29, tool: rule-based-clusters)"
                     /sec_met_domain="SCIFF (E-value: 1.1e-27, bitscore: 87.0,
                     seeds: 37, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MEHIKTLNTKNLQNTVKKGGCGECQTSCQSACKTSCTVGNQSCEQ
                     K"
ORIGIN
        1 tatacatcgc agactctgag tatccgggca cctatgggta tatcatcacc tgctttattg
       61 gacggatatc cactaccatc ataattctca tgatggtaca ggatactctc caatacaaaa
      121 tccgaatatc cctgcccttt aagttcctca tatcccaatg cagaatgcat ccggacatac
      181 ttcagttcct cgatcaccag aggatcctgc tcctgtccgt taatataact tgtcagcttc
      241 agctttccta tatcatggag cattcctgct attgcaagct cataacactg ttcatgcggc
      301 agtcccatct cctctgcaac cgcataagcc agattactta ccagcattcc atgatgcagt
      361 tcagaagcaa ggtcaaattc caggattctc tgctgtgaac ctgctgctgt cttttgtact
      421 gtgtccaaaa tgttacctcc acatcctaca gccaggtagc tattgctgtc cgttttctct
      481 cgatcatctc atcaatgcgg gaaatataat tagaaacgtc ttttacattc tccacacgtt
      541 caattctctg tccatggtca aagaccagct tggaagaacc gcctgccccc agtgcgatga
      601 taggctgttt ttcctccata atcagtatat tgtaaattcc cgctttgtca acctttgcat
      661 agccaacatt ttcaaaattt cccttcatat tcttctgtct gtacagataa taaggaccca
      721 ttcccatttc atacgcagtt ttcatggtca gatccataat ctcctgatta ttctcaaaag
      781 acatttcctg atatttctct ttaaaaatat tcagccttgc tgcacgtttc actgccagtg
      841 aatgtacggt aatactgtcc ggtgccagtt cacgaacctg ttcaagagtc cgctctacca
      901 tgtgaatatc ctcacccggg agtcctacga tcagatccat gttaatgtta tcgtatccca
      961 gctctcgtgc cagatgaaac gcttcttttg tctgctccac agtatgtctg cggccgataa
     1021 tatccagggt ttcctgattc atagtctgtg gatttacgga aattcttgtt accggatact
     1081 ccctgatcgc catcagcttt tcacgtgtaa tactgtccgg tctgccggct tccacagtaa
     1141 actctgccag tccttcatag ccaaaagctt ctcccactgt atccaggagc ttacggatct
     1201 gatgtggaag cagtgtagtc ggggtaccgc cgccaatata gatggtgtcc agttttcttc
     1261 ccttcatcat aagagcagtc tctcttacct cacggcagag agcttccaca tattcatctg
     1321 ttctcttctc ccacactttc agcggatagg agctgaagga acaatacaga cagatacttg
     1381 ggcaaaacgg gattccaata taaaggctgt atccattttc atagtcaata tccttcagaa
     1441 tctctctttc cctgtttgca atagtgatgg caagcgctgt tttctgcgga ctcaccagat
     1501 atctctcacg catctcccgg gctgcttccg tatttttcat tccggattcg atcattccca
     1561 ttgccagttt ggcaggacgt attcctgtca gatttcccca tggaagagtt ctgcccgtca
     1621 gttttaccaa caactgatac agagcatatt tgatattatc tttattctct tttctcagag
     1681 catgagcatc ctgtattcca cagcctgcat tctctttaga aagtatgtct gcggaaatta
     1741 cccctttttg ctctgtttcc tgtttcgaca gattctctgt cctttcgtat tttatgatat
     1801 aactgtcatt atcccgttcc acactgaagc ggaggtcata ctctgcttca ccattttcat
     1861 aaagagtatg tatctccgct tcgggataaa acgctttgat cagttcataa acatcatgtt
     1921 caaaatctct gttcttaaac agaatgccta ttttacacaa atggattata cctcttttca
     1981 taaccaatag tggtagatgc atcatgtccg gggaaaacct cggtctcttc aggaagcgaa
     2041 tctaccagtt tatggagact tctcacaatt tctgctgtac ttccacccgg aaaatccgtt
     2101 cttccaacag agccatagaa cactgtatca ccgctgaaca atacaccttc atctttcaga
     2161 taataacagc agcttccttt ggtatgtccc ggtgtatgga tcatctgaac ggaaaatccc
     2221 gccagtctga taacatccag atcctccaga aatacatccg gcacaataga acatccctgt
     2281 ccataatgta cagtcatatt gatcgaaggt tcgcggagca tctcctcttc ctgacgacag
     2341 gcataaatcg gaatattata tttctccttt actgcctgtg cagccagaat gtggtcaaaa
     2401 tgtccatggg taagaagaat cgccaccggt tttccattca tccgggaaat cttcatttca
     2461 atcttctcca gacaatctgc gggatcaaca atgatcagtt ctccggtttc tttattctta
     2521 aggagatagc aatttgtata tacaggtcct aatatacatt tctgtaattc taaattcttc
     2581 atgttattcc tttctgtcaa tctgcagcag ttccataaaa taatgttcca gcagattttt
     2641 ccatgatcag cctgtagttc tctctacgtc aatgacactc tctacctgac ggatcttctc
     2701 gatcagggaa cgcagttcct ctttgcttcc aatctcaaaa ctcatggaaa tagttgcctt
     2761 ctcctgcttg cttgtacggc tgttgatact tcgcaggtcg atcttacgtt ctgtaaatat
     2821 tttagaaaga tccacaagaa gccctgtacg gttatttgca taaacctgaa tctcagccat
     2881 atacttctct ttttccttgg tatcaggctg ctgccattcc gcctcgatca atcgtgtcct
     2941 gtccgtctca gacatattca gcacattgac gcaatctgta cgatggattg tgattccacg
     3001 tcctcttgta acaaagccta caatctcgtc acccgggatc ggattacagc acttggaaaa
     3061 acggactgcc acatcatgga ttccttttac cacaattcca ctcttgctct tggcaatgtg
     3121 aagcttctcc tgtgtctcag aagcagcctc aagaacctgc tcatctgtca gattcttctt
     3181 attttcctta tcataagcct ctaccagctt attgaaaacc tgaccttctt tcaatccgcc
     3241 atgaccaatt gcagcaagta ctgaatccca gtccctgaaa ccatatttac gcaaaacagc
     3301 ctccagatac tgggtttttg tataatttgc gatcttaaat ccctttgcac gcgcatactg
     3361 cgcaagcatc tccttgccct taaggatatt atcttctttt aattccttct tgaaccactg
     3421 gttaatcttg ttctttgcct gagtactctt aaccagtttc aaccagtcgc ggcttggtcc
     3481 ctgagaattc tgtgaagtaa tgatttcaat acggtcgccg tttttgatct catattcaat
     3541 cggaaccagc ttaccgttaa ctctggcacc taccatctta tttccgactg cactgtgaac
     3601 actgtacgca aaatccaccg gtgtagaacc gcttggaagt gttttaacat ctccctgtgg
     3661 agtgaaacag taaacactgt ccgcaaaaag atccaggtca ttcttcagaa gactcatgaa
     3721 ttctttgtta tcagacatgt ctctctgcca ttccagaatc tgacgcagcc agttcagttt
     3781 ctcttcctca ctcttaccta caggagcctt tccgtcagac gactccttat atttccagtg
     3841 tgcagcgata ccatattctg cagttctgtg catttcataa gtacggatct ggatttcaaa
     3901 gggctgtccg ttgggtccga tcaatgtggt atgcaatgac tgatacatat tgggtttcgg
     3961 catggcaata taatctttaa accgtcccgg aattggctta tacatctcat ggatcacacc
     4021 aagggcagca taacaatcct tcactgtatc tacaagaata cggacagcaa ataaatcata
     4081 aatctgatca atagtcttat cctgatttac catcttcttg tagatgctga aaaagtgttt
     4141 tacacgtccg tccacctgcg ccttaatatt ggcatcatcc atatgtttct taacttcttt
     4201 tacaatcgca cctacaaact gttctctctc gcttttacgc agggcaacct tatgcaccag
     4261 gtcataatat acatccggct taaggtattt cagcgacagg tcatccagct ctacctttat
     4321 cttggaaata cccagacgca tggcaatagg agcataaata tccatggtct ctctggcctt
     4381 ttcctgctgc ttttcaggac gcatatactg taaggtacgc atattatgaa gacggtctgc
     4441 aagcttgatc agaataactc tgatatcctt agccatggca agaaacatct ttctgaggtt
     4501 ctctgcctga acttctactt tatccgcaga ataagataac tgtcccagct tggtaacacc
     4561 atccacaaga agtgcaacct ctgaaccaaa ttccttctca acttcctcat aggtcatcca
     4621 ggtatcttca actgcatcat gaagaagacc tgcaactatc gtttctttgt caagttccag
     4681 atctgccaga atgatggcaa cacacaaagg atgaatgata tatggctctc cagactttct
     4741 cttctgtcct tcatgagctt cacttgcaac cttatatgcc ttctctatca tggaaatatc
     4801 tgttgatgga tgatacttca gaacactgtt tatcagttct ttataaagca cctccggact
     4861 tgtaaaatca tgcatggtct ttactgccgc atctgctctc tttacagatt ccagcttctc
     4921 tttttcaacc tgcatttcat ctttttttgc ttctgtactt tttgttatct ctgtcatatg
     4981 ctcccacctg cctgtcctgc acaatcagct gtgcttattt accatcataa caaattacag
     5041 acgctacatc atacccattc agtctttcgc gtccctttaa acctgcaagt tccatgagaa
     5101 atacaacctt gacaacctca ccgccaagct gttccaccag cttgatcgct gcttcgatcg
     5161 taccgcctgt tgcgatcaga tcatcaacga taaccacttt ctgacctggt tttatggaat
     5221 ctttatgcat ttcaatctct gcactgccat attccagatc atagcttaca gatactgttt
     5281 cgcggggaag tttacctttt ttacgaatcg gtacaaatgg tttatgaaga ttatatgcga
     5341 tcggtacacc aaagataaag cctctggact ctgttcctgc aatcacgtcc acatctatat
     5401 ccttaagaca gtcctgcatg gagtcgattg ccaactgcag gccatccgcg tcctgcagaa
     5461 cacttgtaat atctctgaaa ataatccccg gttcaggaaa atccggtata cttaatacat
     5521 aatcttcaat tttcttcatt ttatttctcc tccagtgtgt gttatattgc tgttcgctca
     5581 taaatatttt atagtatatc acctttttat ttcagaatca agttactgtt aagccctgac
     5641 atttgtattt ccaggcttac cggcggttac aaaccaagcg gtaatattaa cagtaattct
     5701 gaataataat ctgaagactc tctcgtcccc tgaatctgtt gatctccgga taataagtaa
     5761 cagaaatact gtctttttcc ctgataaagt tcacaaaatc ctctgcttct ccgaaataaa
     5821 tgccttccac tgaaatcccc tgcggatcga gaagttttag ttttactaca tttttatttt
     5881 tcccgataat actgtgatca agcactctga gatttttctg cgcaaagacc ggttttgtat
     5941 tcccttttcc aaagggttcc agaagcgaaa tctgttctac cagttctttt gtaatataag
     6001 acacaggcat cggcacatca atcacgatct taggacgcaa ttcttcgtcc gtcaacgtac
     6061 agttgacatt gaggcgtctc cggaattctt ctatattttt ttcttctata gacagacctg
     6121 ctgccatcgg atgacctcca aactgtatca tcaggtctgc acattttacc agttcttcat
     6181 acatagagta actttctatt gatcttccgc ttccttttgc acttgtctca ccgcccgtca
     6241 atacaaaggc cggcctgtga tatttttccc tgatcctgcc tgctataata ccggcaagac
     6301 tttcatgaca atccggaaga taaactacca gtactctgtc atttttcagc tctgtagtct
     6361 ctataatccg gattgcctct tcttttcctt tctcagtgag agcttttcgg ctctgattaa
     6421 gagctgtaag atctccggca agccttgctg cttcttcctt tgtttttgca ttgagaagtg
     6481 caagagaacg ggcagctgta tccagtctgc cactggcatt gatacatggt cccagcacaa
     6541 atccgatatg ataagctgtg attttagcat cttccagaga atttgctcgg atcagttcct
     6601 gcaatccttg atttttggta tttttcagac ggcacagccc ttcttttacc agaatcctgt
     6661 tctctccctg aagatccata acatctccta ctgttgcaat agccgccagt tcataataat
     6721 cttccagctc ctctgccgga acaccaaatc tctcgtaaag tgctgcaata tatttaaagg
     6781 ccaccactgc cccacacagg tttttattcg ggtatggaca atcatattgt ttcggattca
     6841 aaatcgcatc tgccggcgga agcaccatct ggcgttctcc cttttcctcc ctgtaaggaa
     6901 cctcatgatg atctgtaata atcactgtca ttcccttatc ctttgccatc tggatttcag
     6961 cagccgcagc aattccatta tcacaggtca cgatcgtatc gatccggtcc gtttccgctc
     7021 tttctataag atgtgcatga atcccatatc cgtctgcaac tctgtccgga atataagtat
     7081 ccacatctgc tccgatcctc gcaaggcctt tcattaaaat gtatgtagag gtcacaccat
     7141 caatatcata atcaccaata atacggactt ttgctttctg cgatattttt ttctccagga
     7201 tatctacagc tttttccata tccttcatca gccagggaga aggaagctct tgtactgttc
     7261 ctgacagata ctctcttatc ttatcttctc cgatcacatc tctgttcctg atcagtctcg
     7321 caatcaccgg atcaatatga aactgttgac cgatctggtt aaaatctgct ctttttgctg
     7381 ctattaccca tttctccata tattttctct cctcataaaa atatcccgga gttttacccc
     7441 gggatatttc tgtctgcctg tttttcagac aattattgtt ttattcagca tcatcattct
     7501 gctgtttttt agctgcttct tcggcagcca gacgttcagc tactcttttt ctgtttttct
     7561 tctttggctg agtcggatct ttctgtgata catcacgtgc tttcttcggc tttgaagagg
     7621 actttgcaga tgcggaagct gcagcaattg ccggctgtcc ttttcctgca aatttctttt
     7681 tcatcacata ccacaacgca cctgtaatac atacagaaga atatgcaccg acaagaacac
     7741 caaccatcag aggtgctgca aattcacgga tagaagaaac acccatgata taaagaacag
     7801 ctaccataac aaaagttgta aaagaggtat aaatacttct tgtaagagtc tgagtgatac
     7861 ttgtgtttac aatttctgcc agtttttctc tggaaccact gtgaaggttc tcacgtatac
     7921 ggtcaaaaat aacgattgta gcattgatag aataacctac gattgtaagc atgcaggcaa
     7981 taaatgtatt accgacagat actctggcaa tagcatagaa tgcaagtaca accagaacat
     8041 catgcagaag cgccaatacc gcactgcttg caaaacggat gtctttaaat ctgaaccaga
     8101 tataaagaag catacagatt gtagctacta taacggctac gatcgcatca cgacgcattt
     8161 cactacttac tgtagaagaa atactttctg tggaaatcgt gctgtcatct acaccaaatt
     8221 tctcaaccag tgcactctgc agagcttcac gttcgctctg attcagagaa cgtgtcttga
     8281 tcacaacctg atttgttccg actacctttg taggctgaac atttttatct cctgtcacct
     8341 cttctacaac aggagttact tcagaatcaa tggtcttaat atccatatct tcattaaatg
     8401 taacagtcgt agaagtaccg cctgagaact caaggctgta atttaacgct ttgtttcctg
     8461 catgcgaatt agcaaacatc gctgccggac cgcagaggat caggataatg gaaatagcaa
     8521 aaaatacttt cttctttcca aggaaatcaa ctgccttacg ttcttttgca gatccgtaga
     8581 atttcggatc acgtacacca actgcataaa gtgcatttac aatcagtctg gatacaacca
     8641 gtgctgtaaa catggagatc acgataccaa gggcaagtgt ataagcaaat cccttaacag
     8701 tacctgaacc aagccacatc agcacaaagg ctgcgatcag tgttgtaata tttccatcaa
     8761 agattgcaga gaaagctttg ctgaaaccgg acttaataga attccttact gaaactcctg
     8821 caccaatttc ctctctgatt cgggcataaa taataacatt ggcatccacc gccataccga
     8881 taccaagaat aatacccgca atacccggaa gagtaagagt aatatcaaag gcattcagcg
     8941 tgatcagcat taatgatgta taaagaatca gtgcgatacc tgcaactaca ccaggtacgc
     9001 ggtatgcaat gatcataaag ataataacga tgatcagacc gatcgcacct gcaagaacac
     9061 ttgtagagat tgcttcttca ccaagctgtg cagctacaac actggaacga agttcttcca
     9121 gttccagtcc cagagaaccg atacggatat aagaagcaag gttctgtgct tcttccaggt
     9181 cagacattcc gctgatctgt gcttttccgc cggaaatctc ttcatttaca ttcggagcac
     9241 tgataatgtt attgtcatag acgatagcga tctgcttgcc tacattattc tttgtagctt
     9301 ctgcaaattt tgttttacca ctgttttctc catcagaagt aagagtaaga cttaccacat
     9361 attcctttgc acttgtgttc tgattctgga tcgcaccacc ctgggcatct gctacatcag
     9421 aaccttccag aacaacactt ccggattcct tgatctcatc catagttctg gagagaacat
     9481 atccatcctg tcctgtagta aagttctggt ttccgtcagc atcttctttt gtgatgaaat
     9541 acagggaacc tggtttaccc agatcattca aaatagtatc tgcatctgta acaccaggaa
     9601 tttcaactgt aatacggtct gatccttcct ggtatacctg agcctcagta ctgtactgct
     9661 ctacacgctt ctgaagcttg tagatcgtat ctgacatctc ttcgcttgtc ggattgctct
     9721 ccttagcctg gtaggtaatg ctgacaccac cggcaagatc aagacccgtg ttgatatgtt
     9781 ttgctgcacc ggttccggta ggaccgatac ctacggctgc agtaaagcaa aagaacacag
     9841 tcaggatcag tgtcagaagc agcactacga ttcctttact tttcttcata gttcttttcc
     9901 cttcttgatt ttttgtccgc ggtcatgttc atccgcctgc cagccatttt ctgttatgat
     9961 aacagccgac ggcggtatca gtcagacaga ttactgccca ctaatcacat gccagtgcgg
    10021 cttttatcat gatggcgcac tccacacgtt ttctctggag ttcgcatccg atttcataat
    10081 tgcctttgat atctccctgg aaatggaatg catttgccgc acatccgcca ctacagtaga
    10141 aacgtgcgaa gcagtctttg cagtctttct ttgtgtaaac gttgcatccg ccgaattcct
    10201 tctggatttc cggctttgtg atgccttcgt ctacatttcc catgagatac tgttcttcac
    10261 caacaaactg gtgacatggg taaaaatcac cccagggtgt tacagccagg tactctgttc
    10321 ctgaaccgca gcctgacagt ctcttgtata cacaagggcc acctgtaagg tcgatcataa
    10381 aatggaagaa gttaaatcct tttccctctt tctctctttt aatcatttct tttgcaagag
    10441 tatcatactc ttccatgatc tgggggatat cctcctcgcg gatcgcatat tcctccgtat
    10501 cagccgcaac tacaggctct acagaaatct gtttgaatcc aagatctgcc agatgaagca
    10561 catccttgga gaaatcaaga ttatggtggg taaaagtacc tcttacataa tacttgtcct
    10621 gatttctgga ttctgcaaac ttctggaact tcggcatgat caggtcatag cttcctgcac
    10681 cttttctgaa tggacgcatg taatcatgta cttccttacg tccgtccaca ctcagtacaa
    10741 cgttgcccat ctctttattg cagaattcca ttacttcatc attcagaaga actccgtttg
    10801 ttgttaaagt gaaacggaat ttcttattgt gaagcttttc ctgctctctg ccatatttta
    10861 ccagatcttt tacaacctgc cagttcatca gcggctcgcc gccaaagaaa tctacttcca
    10921 ggtttttcct ggaaccggag ttcgcgatca ggaaatcaag agcttttttg ccgacttcat
    10981 aagacataag agctcttctg ccatgatatt cgccttcttc ggcaaaacaa taacggcagg
    11041 ccagattgca gtcatgagca atgtgcaggc acaatgcttt tacaacggtc tgccggttat
    11101 ttgaaaattc ttcaattaca ttctcataaa catcttttgt aaaaagcatt ccatcttctt
    11161 tcagcttatt acattctctt acagatgtct caatatcttc tctgttatat ttgttttcca
    11221 gtttctctgc aatagcttct gtgccaaggc cctcttccag atatggaaga acctcatatg
    11281 taacctcatc taccagatgg atgcatccac tgttgatatc cagtacaata ttaaagccat
    11341 tgcttttata acggtgaatc agactcattt tactaaaatc ctttctaagc gtaagataag
    11401 cagcggaata aaagttccgc tgcttatctc atttctccat agctgatctt atttctgctc
    11461 gcagctctgg tttcctactg tacaggaagt tttacatgcg gactggcagg aagtctggca
    11521 ctcgccacat ccaccttttt ttacagtgtt ctgtaaattc tttgtattca gggttttgat
    11581 atgttccata actctatcct ccttatgtaa ttatattctt ggcatagtat atcatatatc
    11641 ttctcatttt aaaagctttt ttttacgaca gcattccacc cagtgttcca ccgcctgtgc
    11701 acataaaaaa tgttgtaact gcatgagctg cactcatatc ccagccgcct tttgccataa
    11761 cagagacagt caacagtaat acatagtaag ccagacctgt gataacaccc cacagatatt
    11821 tgtctttacg cacaattttg ccggccataa agcccgtctt taggatttag cactttattt
    11881 tttgagagtt aatgaaatat attttatcct caagtcagca tattt
//
