LOCUS       gnlProkkaHICLADAD_6    15724 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|HICLADAD_6.
ACCESSION   gnlProkkaHICLADAD_6
VERSION     gnlProkkaHICLADAD_6
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2025-04-28 09:16:52
            Original ID  :: gnl|Prokka|HICLADAD_6
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 15724
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..15724
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="True"
                     /core_location="[2498:5724]"
                     /cutoff="5000"
                     /detection_rule="(PF04055 and TIGR01716)"
                     /neighbourhood="10000"
                     /product="RaS-RiPP"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      2499..5724
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="5000"
                     /detection_rule="(PF04055 and TIGR01716)"
                     /neighbourhood="10000"
                     /product="RaS-RiPP"
                     /protocluster_number="1"
     cand_cluster    1..15724
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(PF04055 and TIGR01716)"
                     /kind="single"
                     /product="RaS-RiPP"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..15724
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="RaS-RiPP"
                     /region_number="1"
                     /rules="(PF04055 and TIGR01716)"
                     /tool="antismash"
     CDS             3..488
                     /gene_functions="other (smcogs) SMCOG1206:transposase
                     (Score: 138.2; E-value: 6.1e-42)"
                     /gene_kind="other"
                     /locus_tag="ctg6_1"
                     /transl_table=11
                     /translation="MSQEYRALKRYWKLIQQDSRKLNDKRFYRPTFRAHLTNKEILEKL
                     LSYSQELREHYELYQLLLFHFQEKNSDHFFDLIEETSSSVHPIFQTAFRTFLKDKDKII
                     NALELPYSNAKLEATNNLIKVIKRNAFGFRNFENFKKRILMAVNIKKEKTKLVLSRI"
     CDS             complement(580..1752)
                     /gene_functions="transport (smcogs) SMCOG1020:major
                     facilitator transporter (Score: 61.4; E-value: 1.2e-18)"
                     /gene_kind="transport"
                     /locus_tag="ctg6_2"
                     /transl_table=11
                     /translation="MKIKKYAALSIYFNRFSSLISEYGYTILINILLSRISVQLVMYFW
                     VVKCLAAIVTNRINISNSKLSRKYLLILLEITKAILLFLLGFGLNHIIVLLVVFIIEVV
                     NVLFSSLLYSCVPIIIDKDSLIKFNARYTSIGSVSYFLAPLFVGLFINKSHFLLFAVYA
                     LLLIVGATSLLFLPNISTLNLKEERKKQNLNITLFNILRSKKIALVLLSGVIVGSIGVV
                     YDTYEVVYLTKYLGISDSMYSFSLSFLAVSFLVMSFLLSFVKQISSHMKAFALGLSFYV
                     LYLLLFSTSSNIYTVLMSYVFLAIGQTMMGIIETNYFQLSLNMKELQKLYIYSETLHSV
                     FSGIAVLVIGSFAFLSSHLVLVFRSLAVFALFILLCYCVFVNLKKLSIDK"
     CDS             complement(1759..2502)
                     /locus_tag="ctg6_3"
                     /transl_table=11
                     /translation="MKILSIIYDGGSRIPGARFAPTKYYQEAMLYDRKDSDIITINLGN
                     QDLFSIDLESLSRTIAESKVQIALGGDHSVTYLLAKATVREGAYLIVLDAHLDYFKDFE
                     SVVKNWNFLSFLTDIFEKIIIIGERNFEFPSSFDNKIIILSMEEYWLNKSRVLKKLDSY
                     IDESKDIYLSIDIDVLDPSVFDSVSYPIIGGFQMNDFLGIISKILCSDKVYFCDIVEYN
                     PMVGSDNAHIFYQMIQFVKSKLRRI"
     CDS             complement(2499..3596)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RaS-RiPP: PF04055"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_12"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) TIGR04085"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) SPASM"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg6_4"
                     /sec_met_domain="PF04055 (E-value: 6.5e-22, bitscore: 70.6,
                     seeds: 518, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_12 (E-value: 2.1e-10, bitscore: 33.0,
                     seeds: 84, tool: rule-based-clusters)"
                     /sec_met_domain="TIGR04085 (E-value: 7.1e-12, bitscore:
                     37.6, seeds: 281, tool: rule-based-clusters)"
                     /sec_met_domain="SPASM (E-value: 1.9e-09, bitscore: 29.9,
                     seeds: 166, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MYQFSLKKFSDSKSQVIKNVIDFLNNNEISLSKTNTKIVEFSTKI
                     PLKVIQIEVTNKCNLRCMHCYLPDYSKELDRKKISSIVYEAKQLGVMDVDFTGGEPLLL
                     QGLSEIIEEVLKEGMCTTIFTNAVYIPEDFKILIQRYDGIRLKVSLDGWNETIHDSIRG
                     RGTFKRTIKNIEYFRSLGVPVTVNVVLNNKNISGVKYFLELFDRLDVKYAFDRFLPFER
                     NNRLSISDEEFNNAILCIPNIQANCNNISESTFESFYCGAGNSYVFINSSGDVGFCPTL
                     SSTKFCGGNINEKTLNDIWINSKFFNHIRNVRCKYYNECPANYVCQGGCRSRAQFFGGS
                     IGSPDIQECKLAYNLTGIKPKSMSL"
     CDS             complement(3798..3947)
                     /locus_tag="ctg6_5"
                     /transl_table=11
                     /translation="MQVSDAIAQIELAEEEVVSSGLSIDIMEIKPSVATELIDGLKGRC
                     PPSV"
     CDS             complement(4007..4807)
                     /locus_tag="ctg6_6"
                     /transl_table=11
                     /translation="MRIIKFPEQISEDIIHYTFLDDIISYNCEKCRGSCCHVNNSLLLD
                     AKTASFLKRTYLKDFIVSDDSVSLLSCGKKCWFHSELGCTINDLGLNKPLTCELYPFHI
                     KKIQNFYIVSFTPCPTFQLNLGEGQRYKDIEDVVLRYIKTGVPVFSPSLHVSEERLKYE
                     IEYQNNFKNTLSEYYRTKTADGTTEFKEYEKWYIYYLDFRWGSIPLSYTSSQANQFWNL
                     YKRVCEDVYKKISYIRTDNIYFIIANQFNKTISKHFQLNFIDKE"
     CDS             complement(4867..5724)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RaS-RiPP: TIGR01716"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg6_7"
                     /sec_met_domain="TIGR01716 (E-value: 1.6e-45, bitscore:
                     147.3, seeds: 14, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKDYGKLFKKFRESRGLVLKDIAKLGVSVSHISRFERENTDLTIS
                     KFMSALNAINMPIDEFMYAANDFQRDEFNEILEKISLFVSARNVSGMEKLLISQVEKIE
                     KRETFYTLNTILIKIRLQDLSDKSYYDESDIQYLSDYLFSVEYWGCYELLLFANTVDVL
                     NHQTMMLLSREMCKRSEFYKDLPNYRRLHSTMLLNCYIISIERDEYIDSLYFEKQLNHS
                     CFTETEIYEKLVFHYSKNLYELKKNRSNKAILEMKKCIAAMKLANSENLAIKFENHLSG
                     VLKM"
     CDS             complement(6247..8079)
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1190:GTP-binding protein LepA (Score: 550.4; E-value:
                     9.1e-167)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg6_8"
                     /transl_table=11
                     /translation="MPNIEELKQRQEKIRNFSIIAHIDHGKSTLADRILEKTETVSSRE
                     MQAQLLDSMDLERERGITIKLNAIELNYKAKDGETYIFHLIDTPGHVDFTYEVSRSLAA
                     CEGAILVVDAAQGIEAQTLANVYLALDNDLEILPVINKIDLPAADPERVRTEIEDVIGL
                     DASEAVLASAKAGIGIEEILEQIVEKVPAPQGDVEAPLQALIFDSVYDAYRGVILQVRV
                     VNGMVKTGDKIQMMSNGKTFDVTEVGIFTPKAVGRDYLATGDVGYVAASIKTVADTRVG
                     DTVTLADNPAAEPLHGYKQMNPMVFAGLYPIESNKYNDLREALEKLQLNDASLQFEPET
                     SQALGFGFRCGFLGLLHMDVIQERLEREFNIDLIMTAPSVVYHVNTTDGEMLEVSNPSE
                     FPDPTRIDAIEEPYVKAQIMVPQEYVGAVMELAQRKRGDFETMEYIDDNRVNVIYQIPL
                     AEIVFDFFDKLKSSTRGYASFDYELSEYRRSQLVKMDILLNGDKVDALSFIVHREFAYE
                     RGKLIVDKLKKIIPRQQFEVPIQAAIGQKIVARTDIKALRKNVLAKCYGGDVSRKRKLL
                     EKQKAGKKRMKAIGSVEVPQEAFLSVLSMDEDEK"
     CDS             complement(8293..8448)
                     /locus_tag="ctg6_9"
                     /transl_table=11
                     /translation="MALFFCLIKHNVSDNIVINNYVFKGGFPYQTSYTILLSTHFLVLF
                     YWELLY"
     CDS             complement(8467..8613)
                     /locus_tag="ctg6_10"
                     /transl_table=11
                     /translation="MQTFAKDITLKRLSEPEDVAAAVSFLAGPDSNYITGQTIIVDGGM
                     QFH"
     CDS             complement(8889..9272)
                     /NRPS_PKS="Domain: PKS_KR (17-125). E-value: 2.2e-10.
                     Score: 32.6. Matches aSDomain:
                     nrpspksdomains_ctg6_11_PKS_KR.1"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1001:short-chain dehydrogenase/reductase SDR (Score:
                     108.4; E-value: 7e-33)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg6_11"
                     /transl_table=11
                     /translation="MVKLVTTIGRGGFRMSKVAIVTGAGQGIGFAISKRLVEDGVKVGV
                     LDYDAETAEKAVAELSEDKAFSVVADVSKQAEVAAAFQKVVDHFGDLNVVVNNAGVAPT
                     KSLDTITEEQFQRTFNINIGGVI"
     aSDomain        complement(8898..9221)
                     /aSDomain="PKS_KR"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg6_11_PKS_KR.1"
                     /evalue="2.20E-10"
                     /label="ctg6_11_PKS_KR.1"
                     /locus_tag="ctg6_11"
                     /protein_end="125"
                     /protein_start="17"
                     /score="32.6"
                     /specificity="KR activity: inactive"
                     /specificity="KR stereochemistry: C1"
                     /tool="antismash"
                     /translation="VAIVTGAGQGIGFAISKRLVEDGVKVGVLDYDAETAEKAVAELSE
                     DKAFSVVADVSKQAEVAAAFQKVVDHFGDLNVVVNNAGVAPTKSLDTITEEQFQRTFNI
                     NIGG"
     CDS_motif       complement(9147..9215)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ctg6_11_0001"
                     /evalue="1.40E-03"
                     /label="PKSI-KR_m1"
                     /locus_tag="ctg6_11"
                     /protein_end="42"
                     /protein_start="19"
                     /score="11.3"
                     /tool="antismash"
                     /translation="IVTGAGQGIGFAISKRLVEDGVK"
     CDS             complement(9441..9734)
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1163:rhodanese domain-containing protein (Score: 60.2;
                     E-value: 2.8e-18)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg6_12"
                     /transl_table=11
                     /translation="MDIAQIQSELAQDGLLIDVRTPEEYAEGHVKDALLIPHTQFFTAD
                     IPAKKDASIYLYCKMGSRAEFAAGVLKERGYTKVTTLGGLGDMEALGFKFEK"
     CDS             complement(9736..10164)
                     /locus_tag="ctg6_13"
                     /transl_table=11
                     /translation="MKVGNMQKTFFIIKPDAVKRHLIGQVLDRIERRGFVIERMEMLML
                     DEERLKEHYAQLADKPFFPSISEFMMSGPAVIGIMSGPGVIKSWRDMMGATNPGDAAPG
                     TIRGDFATAPDGDMIPNIVHGSDSEESAAREIKIWFGE"
     CDS             10475..11266
                     /locus_tag="ctg6_14"
                     /transl_table=11
                     /translation="MADQKANGIDILTDGKFGRSMWHLDFVWGLKGIERYIAEHGYTFK
                     DHDGGQYETRKDIGIRITEPLSGKNHHYLDIYKLVKAEAGDEDTKQTIWGPAHAYTELA
                     IFDRLAVPGQVYETNEELKKGLINAYKEFLDEYKAVGGKIVQFDDCLWELFDPSNPTSF
                     YSDGNGDLAELADEFVAINNEVVDYTHELGLTVWTHNCRGNYEIRFASEGTYEDIAKKF
                     LAEQHYDRFFLEWDSDTAGDIKALEALKDSKAEVVFGLLSS"
     CDS             complement(11531..12874)
                     /locus_tag="ctg6_15"
                     /transl_table=11
                     /translation="MSQSKADYINVIGAGLAGSEAAYQIAKRGIPVKLYEMRGVKATPQ
                     HKTTNFAELVCSNSFRGDSLTNAVGLLKEEMRRLDSIIMRNGEAHRVPAGGAMAVDREG
                     YAEAVTAEIESHPLIEVIRKEITEIPDDAITVIASGPLTSDALAEKIHELNGGDGFYFY
                     DAAAPIVDKATIDMNKVYLKSRYDKGEAAYLNCPMTKEEFMAFYEALTTAEEAPLNSFE
                     KEKYFEGCMPIEVMAKRGIKTMLYGPMKPVGLEYPEDYMGPRDGDFKTPYAVVQLRQDN
                     AAGSLYNIVGFQTHLKWGEQKRVFQMIPGLENAEFVRYGVMHRNSYMDSPNLLKQTFQS
                     KSNPNLFFAGQMTGVEGYVESAASGLVAGINAARLFKGEDEVIFPHTTAIGSLPYYVTH
                     AESKHFQPMNVNFGIIKELEGPRIRDKKERYEKIAERALKDLQTFIDA"
     CDS             complement(12975..14369)
                     /gene_functions="regulatory (smcogs) SMCOG1003:sensor
                     histidine kinase (Score: 125.4; E-value: 6e-38)"
                     /gene_kind="regulatory"
                     /locus_tag="ctg6_16"
                     /transl_table=11
                     /translation="MALIKKREHSLRTILLSYVVSLTVLSVISSLLILYLFSLSFRFGV
                     VIPANQVESDLSAVRSDIETSKVFNPEILPDGTSYVFLTRDFKLKKSNMLVNLQEESLL
                     NYQFKNAHGEKYGYFQSFERSDGIVIVNYQLSPRYRNEWMNQHFPNADLMMIGSMFVSI
                     LIIFIILTFYYANKLSQQLKPILRVTEKISQQDLDFQTSQSTIKEFNQVLSGLDHMRIA
                     LRESLMENWKAEQDKQNQISALTHDLKTPLTVARGNAELLAMTSLDENQTDLLEHFQKG
                     IAQVDAYVKELSELNKMSLKKTLTLEEVPVKEFVEDIYDQTLSLAQTKQINVVFDKKEI
                     AKESIGNWDKSLLNRAIMNIVSNAVEHTPSGSQLLLTARVEEDEFKFICLDSGPGFSLE
                     SLENATQLFYQEDKSRQSRNHSGLGLTIANDIIRLHYGSLSLANDNGTGGAKVTIILPL
                     LNTDDS"
     CDS             complement(14360..15019)
                     /gene_functions="regulatory (smcogs) SMCOG1008:response
                     regulator (Score: 180.3; E-value: 6.9e-55)"
                     /gene_kind="regulatory"
                     /locus_tag="ctg6_17"
                     /transl_table=11
                     /translation="MARILVIDDQKDIVQLVVKALELQNHNVTGLTSVLDLDKNSLPRF
                     DLILLDIMMPDVDGLQFCHEIRNQVDCPILFITAKTQEADIVQGLSYGADDYICKPFGV
                     KELQARVAAHLRREHRERHHKLSLGEFQFDLSAQELYIENQLLDLTKSEYGICQFLAEN
                     KGQVFSKEQIYTHLYGYEDKGSPAAVAEHIKNIRAKLKEVGQNPIETVWGIGYKWH"
ORIGIN
        1 gtcagtcaca ggaatatcgt gccctgaaac gctactggaa actgatccaa caagatagtc
       61 gcaaactcaa cgataaacgc ttttatcgtc cgacttttcg tgcgcattta accaacaagg
      121 aaatcctaga aaagctactg tcatactctc aagaactgag agaacattat gaactctacc
      181 aacttttact tttccatttc caagagaaga actcggacca tttctttgac ctcattgaag
      241 agacgagttc cagcgtacac cctatctttc agacagcttt tagaactttt ttgaaagata
      301 aagacaagat tatcaacgcc ctcgaactgc cgtattcaaa cgcaaaactg gaagcaacga
      361 acaatctcat aaaggtcatt aagcgaaatg cctttggctt caggaacttt gaaaacttta
      421 agaaacggat tttgatggca gtaaatatta aaaaagagaa gaccaaactg gtcctctcaa
      481 gaatttagct tttcatctac ccactacagt tgacaaagag cccgtttgtc tactttataa
      541 attaactatc tcatttgctt gttttctgat ttataaatat tacttatcaa tgcttagttt
      601 tttgaggttt acaaacacac aataacacag aagaataaac agagcaaaaa cagcaagact
      661 tctgaaaact aaaacaagat gactacttaa aaaggcaaaa cttcctatta ctaaaacagc
      721 aatgcctgaa aatacagaat gtaaggtctc cgagtaaata tatagtttct gtaattcttt
      781 catgttaagt gacaactgaa aataattggt ttcgattatc cccatcattg tctgacctat
      841 cgctagaaaa acataactca ttagtactgt ataaatgttc gaagatgtac taaataaaag
      901 tagatataga acataaaatg aaagacctaa ggcgaaagct ttcatatgag aacttatttg
      961 tttcacgaag ctaagaagga agctcattac taagaatgaa actgctaaaa atgataagga
     1021 aaaggaatac atagaatcac taataccgag atactttgtt aaataaacaa cttcataagt
     1081 atcataaaca actccaattg atcccacaat aactccagat aatagaacta atgcaatttt
     1141 tttggatctc agaatgttaa ataatgtaat gtttaaattt tgtttttttc tttcttcttt
     1201 caaatttaaa gtcgaaatat ttggtaaaaa taaaagacta gtagctccca ctatcaaaag
     1261 aagagcataa actgcaaaca ataaaaagtg acttttatta ataaataaac caacaaacaa
     1321 cggtgctaaa aaataagata ctgaaccaat gcttgtatac ctagcgttaa acttaatcaa
     1381 tgaatccttg tctataataa ttggtacaca actatataat aaactggaaa acaatacatt
     1441 gacaacctca attatgaata caactaatag gacaattata tggtttaatc caaaacctag
     1501 taagaaaagt aagattgcct ttgtaatttc taacagaata agcaggtatt ttctgctcag
     1561 tttactattt gagatattaa tcctatttgt aactattgca gctaaacact ttaccaccca
     1621 aaaatacata actaattgca cagaaattct agacaataga atgttgatca agatagtata
     1681 accatactct gagattaacg atgagaaacg attaaaataa atactcaatg ctgcatattt
     1741 ttttattttc aatatttcct atatcctcct taattttgat ttaacaaatt gaatcatttg
     1801 gtaaaaaatg tgagcattat cacttccaac catcggattg tactcaacta tatcacaaaa
     1861 atatacctta tcagaacata aaattttgga aattattcca agaaaatcgt tcatttgaaa
     1921 tcctccaata ataggatatg atactgaatc aaaaacagat ggatccaaaa catcaatgtc
     1981 tattgataag taaatatctt ttgactcatc aatataacta tctaactttt tcaaaactct
     2041 actcttattt aaccaatact cctccattga gaggatgatt attttattat caaatgaact
     2101 aggaaactca aaattccttt ccccaatgat aattattttt tcaaaaatat cggttaaaaa
     2161 acttaaaaaa ttccaatttt ttacaacact ttcaaagtct ttgaagtaat ctaaatgagc
     2221 atctaaaaca attaaatatg ctccctctcg aacagtggcc tttgctaata gataagtaac
     2281 tgaatgatct cctcctaaag caatctgaac tttagattca gcaatagttc gacttagact
     2341 ttctaaatca atagaaaata aatcttgatt acctaaatta attgtaatta tatcagaatc
     2401 tttcctatca tataacatcg cttcttgata atattttgtg ggagcaaatc tcgctcctgg
     2461 aattctactt ccaccatcat aaataataga taatattttc ataaactcat tgactttggc
     2521 ttaatcccag ttaaattata tgctaacttg cactcctgta tatcgggact cccaatagaa
     2581 cctccgaaaa actgagctcg acttctacac ccaccttgac aaacataatt tgcagggcat
     2641 tcattataat acttacatcg tacatttcga atatgattga agaacttcga attaatccaa
     2701 atatcattta aagtcttttc attaatgtta cctccacaaa atttagtgga ggataatgtc
     2761 ggacaaaatc caacatcacc tgacgaattt ataaacacat aagaattgcc agcaccacaa
     2821 taaaatgatt caaatgtgga ttcggatata ttattacaat ttgcttgaat attgggaata
     2881 cacaaaatag cattattgaa ttcttcatca ctaattgata gtcgattatt cctttcaaaa
     2941 ggtaaaaacc tatcaaaagc atatttcaca tctaatcgat caaacaactc caaaaaatac
     3001 ttcactccac taatattctt gttattcaaa acaacattaa cagtaacagg tactcctaaa
     3061 ctcctaaaat attcaatatt cttaattgtt ctcttaaatg tacctcttcc tctaattgaa
     3121 tcatgtattg tttcattcca accatctaaa ctaactttta gtcttatacc atcatatctt
     3181 tgaatcaata ttttaaaatc ctcaggaata tatacagcat ttgtaaaaat tgttgtacac
     3241 attccctctt ttaatacttc ctcgataatt tcacttaatc cctgtaataa taatggttcg
     3301 cctccagtga aatcaacatc cattactcct agctgcttag cttcatatac tatacttgaa
     3361 attttctttc tatcgagctc ctttgaataa tcaggtaaat aacaatgcat acatcttagg
     3421 ttacatttgt tcgtgacctc aatctgtatc acttttaatg gtattttcgt tgaaaattca
     3481 acaattttag tgttggtctt agagagtgat atttcattgt tatttagaaa atctataaca
     3541 ttttttatta cctgactctt tgaatcagaa aactttttca atgaaaattg gtacataaat
     3601 tttaaagcta aaaatgtagc taaatttaat gaaaatagtt tattattcct attattcctg
     3661 agtattcctt gcttattgta ccaattaaaa aaatcgagta aacattgctc gtcatattaa
     3721 ttccctgcaa tcttccaaaa atattaatat aaaaaccaaa ggattagaaa tagactctaa
     3781 tcctacaatc agttctatta gacagacggt gggcaacgac ctttgagtcc atcaatcaac
     3841 tctgtagcaa cagaaggttt aatttccata atgtcaatag atagaccgct agaaacaact
     3901 tcttcttctg ctaattcaat ttgtgcaata gcatcactaa cttgcatcgt aatatcctcc
     3961 attatttatt taagaatcaa taagtaccca taacaaatca tagaaatcat tctttatcta
     4021 taaaatttag ctgaaaatgc tttgaaattg tcttattaaa ctgatttgca ataataaagt
     4081 atatgttatc tgttcgtata tatgatattt ttttataaac atcttcacaa actctcttgt
     4141 aaagattcca aaattgattt gcttgtgaac ttgtataaga taagggtata cttccccatc
     4201 taaaatctaa ataatatata taccattttt catattcttt aaactctgta gtcccatcgg
     4261 cagtctttgt tcgataatac tctgataaag tgtttttaaa attgttttga tactcaatct
     4321 catatttcag cctttcctct gaaacatgca aagacggact aaaaactggc accccagttt
     4381 taatatatcg taaaactaca tcctctatat ccttgtacct ctgcccctca ccaaggttca
     4441 gttgaaatgt cggacaagga gtaaaagaaa caatatagaa gttctgaatt ttcttaatat
     4501 gaaaaggata taattcacaa gttaatggct tgttcaagcc taaatcattt atcgtacaac
     4561 ccaattcaga atgaaaccag cactttttac cacaactcaa caatgaaaca ctatcatcac
     4621 taacaataaa atctttaaga tacgtgcgtt ttagaaaact tgctgtcttt gcatcaagta
     4681 ataaagaatt attcacatga caacaagatc ctctacactt ttcacaatta taagagataa
     4741 tatcatctag aaacgtataa tgaatgatat cttctgaaat ctgttcagga aatttaataa
     4801 ttctcatatc aataatatat catttaattt tgacactgat aatttatacc atatacacaa
     4861 atccaactac atttttaaca ctccagataa atgattttca aattttatag ctaaattctc
     4921 actattagcc agcttcattg cagcaataca cttcttcatt tctagaatag ctttattgct
     4981 cctattcttc tttaattcat ataaattttt tgaataatga aacactaatt tctcgtaaat
     5041 ctcagtttcc gtaaaacaac tatgatttaa ctgtttttca aaatacaacg aatcaatata
     5101 ctcatctctt tcaatactta tgatataaca atttaatagc attgttgagt gtaaccttcg
     5161 gtagtttggt aaatccttgt aaaattctga acgtttacac atttctcttg ataaaagcat
     5221 cattgtttga tgattcaata catctacagt attcgcaaat aacagtagtt cgtaacaacc
     5281 ccaatattct acagagaata ggtagtctga taaatattgg atatcagatt catcatagta
     5341 acttttgtct gataagtcct gtaaacgaat ttttattaaa atagtattta gagtataaaa
     5401 agtctcacgc ttttcgattt tttctacttg agagattaat aacttttcca tacctgacac
     5461 gttccttgct gaaacaaata aactaatctt ttctaagatt tcattaaact catctctctg
     5521 aaagtcgttt gctgcataca taaactcatc aataggcata tttatcgcat ttaaagctga
     5581 cataaactta ctaattgtca aatctgtatt ttcacgttca aagcgggaaa tatgagatac
     5641 tgatacgcct aactttgcga tatcttttaa gactaatccc ctagactctc taaatttctt
     5701 aaataatttt ccataatctt tcataaaaag cacctctttt gcatatacga gaatttccca
     5761 gataaactta aaagtattat atcatatagt gagataggag gttaatttct atgaataaag
     5821 aaagtttttt agctatctta cttctaattt ttgaaagcat tattgtaatt gctgttggct
     5881 aaacaaatag aaaataaaga caccacaaaa gttagacttt cgatgtctaa cttttgtggt
     5941 gtagttaagg tatgatgttg ttctctaata agggtataat ataaaaaaga ctctatgatt
     6001 tctgtagtag gtaaaaccac tatagagatt atagagcttt ttgagtgtat acaaaaacta
     6061 gttctttatt ggaacaaagt caacaactaa tctagtattg gttgcagcgg caatttcttc
     6121 caatgtttta tatgttggat tagtggtgcc attctctata cgtcactttg agaaggtaaa
     6181 ttttaaaatc ctctttatca taacttttta ctaaaatagc cagaacatca cattctacta
     6241 tcattcttat ttctcatctt cgtccattga aagcacagac aagaaggctt cttgtggtac
     6301 ctccaccgaa ccaatggctt tcatacgttt cttaccagct ttttgttttt cgaggagttt
     6361 acgtttacgt gaaacgtcac caccgtaaca tttagccaag acgtttttac gaagagcttt
     6421 gatatctgta cgggcaacaa ttttttgacc aatagccgct tggataggaa cttcaaattg
     6481 ttgacgtgga ataattttct taagtttatc aacgataagt tttccacgtt cgtaggcaaa
     6541 ttctctatgg acaataaagc taagggcatc gaccttatca ccattaagga gaatatccat
     6601 tttcaccaat tgtgaacgac ggtactctga caattcatag tcaaaacttg cataaccacg
     6661 agttgatgac ttcaatttat caaagaagtc aaagacgatt tcagcaagtg gaatttgata
     6721 gataacgtta acacgattat catcaatata ttccatggtt tcaaaatcac cacgtttacg
     6781 ttgcgccaac tccataacag caccaacata ctcttgagga accataattt gagctttgac
     6841 ataaggctct tcaatggcat caatacgtgt aggatctgga aattcagatg ggttggacac
     6901 ttcaagcatt tcaccgtcag tagtgttaac atggtaaact actgatggtg cagtcatgat
     6961 gagatcgatg ttaaactcac gttccaaacg ctcttggata acatccatgt gaagaaggcc
     7021 caagaaacca caacggaaac caaaaccaag ggcttgagac gtttcaggct caaattgaag
     7081 actggcatca ttcaattgga gcttttcaag agcctcacgc aagtcgttat atttatttga
     7141 ctcaattgga taaagaccag caaagaccat tgggttcatt tgcttataac catgaagtgg
     7201 ttctgcggct ggattatccg caagtgtcac tgtatcaccg acacgagtat ccgcaactgt
     7261 cttaattgaa gctgctacat aaccaacatc tccagtcgca aggtagtcac ggccaacagc
     7321 tttaggagtg aaaataccaa cctcagtaac gtcaaaggtc ttgccattag acatcatttg
     7381 aatcttatcg cccgttttaa ccattccgtt aaccacacgc acttggagta tgacgccacg
     7441 atacgcatca taaacagagt caaagataag ggcttggaga ggtgcttcca catcaccttg
     7501 gggcgcagga actttctcaa caatttgttc gagaatctct tcgataccaa tgccagcctt
     7561 agctgatgca agcacagctt ccgaggcatc taatccgata acatcttcaa tctctgtacg
     7621 tacacgctca ggatctgccg ctggaaggtc gattttattg ataactggta agatttccaa
     7681 gtcattatca agtgccaagt aaacattggc aagtgtttgt gcttcaatcc cttgagctgc
     7741 atctaccacc aagatagcac cctcacaggc ggcaagggaa cgtgacacct cataagtaaa
     7801 gtccacatgt cccggtgtgt cgataaggtg gaaaatataa gtctcgccgt ctttagcttt
     7861 gtagttaagc tcaatggcat tcagtttgat agtgatacca cgttcgcgct caagatccat
     7921 actatcaagg agttgtgcct gcatctcacg acttgataca gtctcagtct tttccaagat
     7981 acggtcagca agcgttgatt taccatggtc aatatgagca ataatcgaga agttgcgaat
     8041 cttctcctgt ctttgtttta attcttcaat atttggcatt ttattctttc ctaattctta
     8101 cttgtgattg ttaaaaaacg aaccgtcacc tcctattata caaaaaagac aggcatttgc
     8161 ctatctctaa tatctgcttt atgactgcat ttagtccttc ttatttctta aaattatcat
     8221 tgtagtgctt attaataata gctgaacgct tgttctctat tgaactactt gaaaatggag
     8281 ctaaaccaaa ggctagtaca ataattccca atagaataag actaaaaaat gggtgctcag
     8341 caatatagtg taagatgtct gatatgggaa tccaccttta aaaacataat tatttataac
     8401 tatattatca gaaacattat gttttatcaa gcaaaaaaag agagccattc gctctccctt
     8461 ttaaccttaa tggaattgca taccaccatc aacgatgatt gtttgacctg tgatgtagtt
     8521 tgagtcaggt ccagctagga agctaactgc tgctgcaaca tcttcaggtt ctgacaaacg
     8581 tttgagggta atatctttag caaaagtttg cataccccac tcatcatctt taccagcatt
     8641 ttaccaactt cgtgggcaat gtcaaacatc attggagtct taacgatacc tggtgcataa
     8701 gcatttacag ttatacctga atcagctaag tcacgcgcca aagtttgagt aataccacga
     8761 actacgaatt tagttccacc atatacagtt aagttagagt tccctacgac acctgcttgt
     8821 aaagttgcat tgataatttt accaccatga ccaagtgatt taaattgtgc ttgggcagct
     8881 tgtgcacctc agataactcc accaatatta atgttaaatg tacgttgaaa ctgttcttca
     8941 gtaatagtgt caagggattt tgttggtgcc acaccagcat tattaacaac aacattcaag
     9001 tcgccaaagt gatcaactac tttttggaaa gctgctgcta cctcagcttg tttagacaca
     9061 tctgctacaa cggaaaatgc cttgtcttct gacaactcag caactgcttt ttcagcagtt
     9121 tcagcgtcat agtccaatac cccgacttta acaccatctt caaccaagcg ttttgaaatc
     9181 gcaaaaccaa taccttgacc tgcacctgta acaatagcaa cttttgacat acgaaatcct
     9241 cctctaccaa ttgtagtcac aagcttaacc acaagcccta cctcaattgg aatatgctaa
     9301 gttaatcaag ttctggcaaa gtcattttca taggcttttt cttaactcat ttagaatctt
     9361 accactttat gaaagcgttg ttaataattt gtcatgcttt ttgaaagcaa ataagatcac
     9421 cactagtgac cttatgtgta ttatttttca aacttaaacc ctagtgcttc catatcacct
     9481 aggccaccta aggtggtaac cttagtatat cctcgttctt tcagtactcc tgcagcaaat
     9541 tcagcacgag atcccatttt acaatagagg taaatggagg cgtctttttt agctggaatg
     9601 tcagctgtga aaaactgcgt gtgaggtatt aataaagcat ccttaacatg accttctgcg
     9661 tactcttctg gagtcctgac atcaattaat agtccatcct gagctaattc tgattgaatc
     9721 tgtgctatat ccatcctact caccaaacca aatcttaatt tctcgagccg cagattcttc
     9781 tgaatcagag ccatgaacga tatttggaat catgtcacca tctggtgctg ttgcaaagtc
     9841 tccacgaatc gttccaggag cagcatcccc aggattagtt gctcccatca tatcacgcca
     9901 tgacttaata actcctgggc cggacataat accaataact gctggaccac tcatcatgaa
     9961 ttcagaaata ctagggaaaa aaggtttatc agccaattgg gcataatgtt ctttaagacg
    10021 ttcttcgtca agcatcagca tctccatacg ctcaataacg aagccacgtc gctcaattcg
    10081 atcaagcact tgaccaatta gatgacgttt aacagcatct ggtttaataa taaagaatgt
    10141 tttttgcata ttcccaacct tcatcgtttt ctttccattt tatcataaga agtatcattt
    10201 tgcagagcta aaccttgtat agtctaaaac tatatacaca gcaagaaatt aactattttt
    10261 cattagttcc cataagaaat aatatagatg taaatagaca tttcgaggta aatttaatga
    10321 caaaatctaa attccaatta gtcggttctc ttcttcgtcc tgcggatctc cgtaaataca
    10381 aggacgaaat cgagcatcgt gacgacatcc agtatccttt ctatgatgcc cttcctggtt
    10441 atcaagaaac tgaaactgca tctattaagc gaatgtggct gaccaaaaag ctaacggaat
    10501 tgacatcctt accgatggga agtttggacg ttctatgtgg cacttggact ttgtctgggg
    10561 actcaaaggt attgaacgct acattgctga gcatggttat acttttaaag accatgatgg
    10621 tggtcaatat gaaacacgta aagatatcgg tattcgtatc actgagcctc tatcaggtaa
    10681 aaaccaccac tacctagata tttacaaatt ggttaaggct gaagctggtg atgaagatac
    10741 caaacaaact atctggggac ctgctcatgc ctacactgaa cttgctatct ttgatcgatt
    10801 ggctgttcct ggacaagtct atgaaacaaa cgaagaactc aaaaaaggtt tgattaatgc
    10861 ctataaagaa ttcttggatg aatacaaggc tgttggtggt aaaatcgttc aatttgacga
    10921 ctgcctctgg gaactttttg acccatcaaa ccctacaagt ttctactcag acggcaatgg
    10981 tgatttggca gaattggccg atgaatttgt tgctatcaat aatgaggttg ttgactatac
    11041 tcacgaactt ggtttaacgg tttggacaca caactgtcgt ggtaattatg aaatccgttt
    11101 tgcttctgaa ggaacttacg aagacatcgc taagaaattc ttggcagagc aacactatga
    11161 ccgcttcttc cttgaatggg atagcgatac agctggtgat atcaaagctc tggaagccct
    11221 taaagacagt aaagctgaag ttgtatttgg gctattgtct tcttaaacga ctgacctaga
    11281 tgacgaagaa cgtgttctcg atttgcttga aaaagcgagt caaatccttc caaaaaaacg
    11341 tctcttcccc tttcaccaat gtggtttcgc ctcatgtgac tcaggtaatg agctggcaac
    11401 acctcaacaa tgggctaaaa tcaaacaagg tcaagaaatc gctaagaaat tctttggcta
    11461 atcgatattt ctattcgctc ctctctaaaa cgaaaagcct tcactcttgt gagggctttt
    11521 tatgttagca tcaagcatct ataaaagttt gcaaatcctt aagagctctt tctgcgattt
    11581 tttcataacg ctctttcttg tcacgaatac gtgggccttc taattctttg ataataccaa
    11641 agttaacatt cattggttga aaatgtttgc tttcagcatg tgtcacataa tatggaaggc
    11701 taccgattgc tgttgtatga gggaaaataa cttcatcttc acccttaaag agacgggctg
    11761 cattgattcc agcaaccaaa cctgaggcag ctgattcaac ataaccttca acaccagtca
    11821 tttgtccagc aaagaacaga ttagggtttg attttgattg gaaggtctgt ttaagcaagt
    11881 ttggcgaatc catgtaagag ttacggtgca ttaccccata acgaacaaat tctgcatttt
    11941 caagacctgg aatcatttgg aagacacgtt tttgctctcc ccatttgagg tgggtttgga
    12001 aaccaacgat attgtagagg ctaccagccg cattgtcctg acgaagctga acaaccgcat
    12061 aaggtgtctt gaagtcacca tcacgtggac ccatataatc ttcaggatac tccaaaccaa
    12121 ctggtttcat aggaccgtag agcattgttt taataccacg tttagccata acctcgatag
    12181 gcatacaccc ttcgaaatac ttttcttttt caaaagaatt caaaggagct tcttcagctg
    12241 tagtcaaggc ctcatagaag gccatgaact cttccttggt cattggacag tttagataag
    12301 ctgcttcacc cttatcatag cgtgacttaa ggtaaacctt gttcatgtcg atagttgctt
    12361 tatcaacgat tggtgcagcg gcatcataga aatagaaccc gtctccaccg ttaagctcat
    12421 gaatcttttc agctaaagca tcagaagtta ggggacctga agcaataact gtaatagcat
    12481 catcaggaat ttctgtgatt tctttacgga taacttcaat taagggatga ctttcaattt
    12541 cagctgtcac tgcttctgca tagccctcac ggtccaccgc catggcacca cctgctggca
    12601 cacggtgagc ttctccatta cgcataatga tagagtccaa acgacgcatt tcttctttta
    12661 gaagccctac agcattggtc aagctatctc cacggaaaga gttagagcaa accaattctg
    12721 caaaatttgt tgtcttatgc tgtggtgttg ctttgacccc acgcatttca taaagtttta
    12781 ctggaatacc acgtttggca atctgataag ccgcctcgga tccggccaaa ccagctccaa
    12841 tcacgttaat ataatctgct tttgattgag acatgacact aatacctctt cggaaacaag
    12901 atgaaatcct gctcccacaa atctttcttc atttttactc ttagtagtat agcaaaaaac
    12961 tcctcatctg gcgactagga gtcatctgta tttaaaaggg gtaaaatgat agtcacttta
    13021 gcaccacccg tgccattgtc atttgcaaga gaaagactac catagtgtaa acgaataata
    13081 tcattagcaa tagtcagacc aaggccacta tgattgcgac tctgtctgct tttatcctct
    13141 tgataaaata gctgagtagc gttttcaaga gattcaaggg aaaatccagg accagaatca
    13201 aggcatataa acttgaattc atcttcttct accctagcgg tcaggagcaa ctgactgcca
    13261 ctgggtgtat gctctacggc atttgaaaca atattcataa tagctcgatt caacaaggac
    13321 ttatcccaat tgcctatgct ttctttcgca atttccttct tgtcaaatac cacattgatt
    13381 tgtttcgttt gagctaatga caaggtttga tcgtaaatgt cttcaacaaa ttccttaact
    13441 ggaacttctt caagcgtcag ggtcttcttc aaactcattt tgttgagttc tgacaactct
    13501 tttacataag catcaacctg tgcaatacct ttttgaaaat gctctaacaa gtccgtttga
    13561 ttttcatcca aggacgtcat agctaagagt tccgcatttc cacgagcaac tgttaggggc
    13621 gtctttaagt catgtgttag ggcagaaatc tgattttgtt tatcttgctc tgccttccaa
    13681 ttttccatca aagactcacg aagtgctata cgcatatgat ccaaaccact taaaacctga
    13741 ttaaattcct taattgtaga ctgagaagtt tgaaaatcca aatcttgttg ggaaattttt
    13801 tcagtaaccc ttaatatagg tttaagttgc tgactcaatt tatttgcata ataaaaagtt
    13861 aaaataataa atattattaa gatagataca aacattgaac caatcatcat aagatcagca
    13921 ttgggaaaat gttggttcat ccactcatta cggtaccgag gtgatagttg ataattaaca
    13981 atgactatgc catctgaccg ttcaaaagac tgaaaatagc cgtatttctc accgtgagca
    14041 ttcttgaatt ggtaatttag taaggattct tcttgcaagt taacaagcat gttagacttt
    14101 ttaagcttaa aatccctagt taaaaagaca taactcgtgc catcaggtaa aatctcggga
    14161 ttaaagacct tagaagtttc aatatcactt ctcacagcag acaaatcact ctcaacttga
    14221 tttgctggaa tcacaactcc aaaacgaaaa gacaagctga acaaatacaa aataagaaga
    14281 ctgctgatta cagagagaac tgtaagactg acgacataag ataacaagat tgttcttaga
    14341 gagtgttctc gtttttttat tagtgccact tgtaaccaat cccccaaact gtttcaatag
    14401 gattttgccc aacttcttta agctttgcac ggatattctt gatatgttca gccactgctg
    14461 ccggactgcc tttatcctca tagccgtaca aatgcgtgta gatttgttct tttgaaaaga
    14521 cttggccctt attttcagct aaaaactggc aaataccata ttccgacttt gtcaaatcta
    14581 acaactgatt ctcaatataa agctcttgag cagacaagtc aaactgaaac tccccaagtg
    14641 aaagcttatg gtgacgctca cgatgttcac gtctcaagtg agctgcaaca cgcgcttgga
    14701 gttctttaac cccaaatggt ttgcaaatgt aatcatccgc accataactc aacccttgga
    14761 caatgtctgc ttcttgcgtt ttagctgtaa taaagaggat tgggcaatcc acctgatttc
    14821 gaatctcatg gcaaaactgt agaccgtcaa catcaggcat cataatatcc agtaaaatca
    14881 ggtcaaatcg aggtaaagag ttcttatcca aatccaaaac acttgtaagc cctgtcacat
    14941 tatggttttg gagctctaaa gcctttacaa ccaattgaac aatatctttt tgatcatcaa
    15001 taacaagtat tcgagccata gcctctcctt tccttcaaag ttatccttat catatcatct
    15061 atagaagata actgacaagg cgtaaagtag ataaatatgg gttgggtaaa aaacatagaa
    15121 caaatatttt gaccctttcc ctctttgacc gttataagaa agcattaaag gtgctgaaaa
    15181 tatttccatc cattcaaagt atttgaatat taaatcgtga aaagaaggtc tacttaaaac
    15241 aatcgccatt agcagccaaa cgagactaac actcataaaa gcaagcactt ctttcttaag
    15301 attcctatga caaagataca tagcgatacc ggtcaaaagc aaccacgttc ctccatcatt
    15361 gataaatgta tggactggca atactgtgaa attgagtaaa tttagtagaa aaccaaacat
    15421 aggtttgttc acacttagca gataaaaagg caccattaac catggaagca acaatggaaa
    15481 aagtaaagtt ggtatccctt taaggtattt cttttcttga atccatgcaa tcccttgaag
    15541 agcaacgagc aaaattgcga atgacgacag catcatattt tgtggaaaga aaccatctgg
    15601 tctaactaga ggatgtagaa aattatagaa tccaaattga atcagtccca tcacaattgc
    15661 taaagaataa atctttagga agtatttctt ccggttatgg gtatgaataa aaccctcaat
    15721 caca
//
