LOCUS       gnlProkkaGGJKJGJI_529  12142 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|GGJKJGJI_529.
ACCESSION   gnlProkkaGGJKJGJI_529
VERSION     gnlProkkaGGJKJGJI_529
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2025-04-28 09:02:49
            Original ID  :: gnl|Prokka|GGJKJGJI_529
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 226384
            Orig. end    :: 238526
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..12142
                     /aStool="rule-based-clusters"
                     /category="other"
                     /contig_edge="False"
                     /core_location="[5000:7142]"
                     /cutoff="20000"
                     /detection_rule="(phosphonates and minimum(1,
                     [2-Hacid_dh_C, Aldedh, Aminotran_1_2, Aminotran_5, AurF,
                     CTP_transf_like, DUF4992, Fe-ADH, HMGL-like, Metallophos_2,
                     NTP_transf_3, NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C,
                     TPP_enzyme_N, phosphonates]) and not (phosphonatesHydrolase
                     or phosphonatesMeIsocitrateLyase))"
                     /neighbourhood="5000"
                     /product="phosphonate"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      5001..7142
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(phosphonates and minimum(1,
                     [2-Hacid_dh_C, Aldedh, Aminotran_1_2, Aminotran_5, AurF,
                     CTP_transf_like, DUF4992, Fe-ADH, HMGL-like, Metallophos_2,
                     NTP_transf_3, NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C,
                     TPP_enzyme_N, phosphonates]) and not (phosphonatesHydrolase
                     or phosphonatesMeIsocitrateLyase))"
                     /neighbourhood="5000"
                     /product="phosphonate"
                     /protocluster_number="1"
     cand_cluster    1..12142
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(phosphonates and minimum(1,
                     [2-Hacid_dh_C, Aldedh, Aminotran_1_2, Aminotran_5, AurF,
                     CTP_transf_like, DUF4992, Fe-ADH, HMGL-like, Metallophos_2,
                     NTP_transf_3, NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C,
                     TPP_enzyme_N, phosphonates]) and not (phosphonatesHydrolase
                     or phosphonatesMeIsocitrateLyase))"
                     /kind="single"
                     /product="phosphonate"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..12142
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="phosphonate"
                     /region_number="2"
                     /rules="(phosphonates and minimum(1, [2-Hacid_dh_C, Aldedh,
                     Aminotran_1_2, Aminotran_5, AurF, CTP_transf_like, DUF4992,
                     Fe-ADH, HMGL-like, Metallophos_2, NTP_transf_3,
                     NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C, TPP_enzyme_N,
                     phosphonates]) and not (phosphonatesHydrolase or
                     phosphonatesMeIsocitrateLyase))"
                     /tool="antismash"
     CDS             complement(1430..2872)
                     /locus_tag="ctg29_219"
                     /transl_table=11
                     /translation="MEKHQMKQLYQDIDVPKAELKNVIHSAAVRAGKEGAVRRRWGRKV
                     INGLAVAAALFILYLSSGLFMPSVNTAMGNIPVAGQIYSLFQDKAGSALFKSNLVTKLN
                     EKAESRGITVTVKSVYYDSGQLVYNFTVDNLKSDEESISFQVDYKDPWNMLAEDYDNSD
                     MKKMKDGRYAGQLRLFTDGSKLKDGDKLPLVITKIKDIPGNWRFTLPIKKQKSVSLEGT
                     KAVNVNHGLYRFFDIRAENGTTGSALLYSIDFYDAAKNDAISIYEATDDAGNHYEMTAS
                     NIELGGRKNLPGGGKRIRGQTQFSKPIDPKAKTLFITGDIKTESEPGEIVPLKTKLPVS
                     YKTKHHHVGITIKKIKQQGRTVIVDYQFTGINYSKADEDQLINVGESIGLGNTKKMKTW
                     PSLNEYEKGYYLKGNKAKVTNLKTGEMESVFELDDSTDKDYSLRDFSFDSYALYVNQTV
                     MNLLADDKGITFAVPVRPADGK"
     CDS             complement(2854..3387)
                     /gene_functions="regulatory (smcogs) SMCOG1032:RNA
                     polymerase, sigma-24 subunit, ECF subfamily (Score: 104.2;
                     E-value: 9.9e-32)"
                     /gene_kind="regulatory"
                     /locus_tag="ctg29_220"
                     /transl_table=11
                     /translation="MKEERLIKKAKKGDAAAFEKLITAHQDTLYKTAYLYLHHKEDTLD
                     AVQETAYKAFLHIAQLKEPKYFKTWLIRILLHTIFAMKKKHGDVIPFEPQHDTRAENKN
                     IEEYIDLRNALETLDEHIQLTIQLYYFQDFSIAMIAEQTGMAEGTVKTHLHRARKALKQ
                     ELEKEDKHIWKSIK"
     CDS             complement(3704..4936)
                     /gene_functions="transport (smcogs) SMCOG1202:major
                     facilitator transporter (Score: 255.4; E-value: 1.1e-77)"
                     /gene_kind="transport"
                     /locus_tag="ctg29_221"
                     /transl_table=11
                     /translation="MKGIRLRIHPVGWNIILGTLFSRMSVSMSIPFLSIYLTQVKGVSP
                     ALTGIIVSVSSLAGIVMSFYGGYLSDLFGRKIVMITSVFCWALVFVSFMFADSVLAFFV
                     INALNGLCQSIFEPASRALLSDISKEENRLKMFNLRYTAINIGVVFGPLLGLRLGAAKT
                     ALPFLFAGFTYFLYGLSLLFSFRKFKLDENNRKENKTTIATAFNVTRKDKVFLITLLGV
                     ILSISGYAHFSTTLPQYFAAKIEDGVTIFSWLLALNAIVVLIVQYPIVNIMKKFPPIHS
                     IILGNALISFSLLFFSLSSNPFIWGSIVVFFTIGEVLIFSMVDMLVDEIAKPGFKGTYF
                     GAAGFNRLGNVIGPWLGGILLSFFGVNGSFYMFLIIFITTASGIPVLFLAKKHLDKSGH
                     SKVDVTESHRS"
     CDS             complement(5001..6200)
                     /NRPS_PKS="Domain: Aminotran_1_2 (32-388). E-value:
                     1.9e-69. Score: 226.3. Matches aSDomain:
                     nrpspksdomains_ctg29_222_Aminotran_1_2.1"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: Aminotran_1_2"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) DegT_DnrJ_EryC1"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1019:aminotransferase (Score: 287.8; E-value:
                     2.2e-87)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg29_222"
                     /sec_met_domain="Aminotran_1_2 (E-value: 1e-68, bitscore:
                     226.2, seeds: 48, tool: rule-based-clusters)"
                     /sec_met_domain="DegT_DnrJ_EryC1 (E-value: 6.8e-11,
                     bitscore: 36.0, seeds: 38, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNKRLSDRVMNIKPSATMSLNAKTKIMVKEGKDIINMSVGEPDLH
                     PPLTASYAGIQAIVKGKTGYTPAAGLIELRESIVRYLLNERGLEYKPNQIIASAGGKQP
                     LYNVFQAICDQDDEVILPSPYWVSYPEQIKLSGAVPVIVSCDETTNFKITPEKLAEVIT
                     PKTKAVVITSPNNPTGSVYSENELKALGNVLKDYSEIFIISDEIYDQFVYEGKHISLPL
                     IFPELLNRTIITNGFSKVFAMTGWRLGYIAAPSDIAEAIASFQSHATGSPSTISQYAGI
                     SALNGFDKSMVEEYKKRRDILVDGLNQIEGIQCAKPNGAFYAFPNVSQFFGTMFEDQQI
                     IDAETFCHLLLEKQHVSAVPGTAFGEPNNIRLNFAIPKDLITEALKRINNFTTQLAVKV
                     "
     aSDomain        complement(5037..6104)
                     /aSDomain="Aminotran_1_2"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg29_222_Aminotran_1_2.1"
                     /evalue="1.90E-69"
                     /label="ctg29_222_Aminotran_1_2.1"
                     /locus_tag="ctg29_222"
                     /protein_end="388"
                     /protein_start="32"
                     /score="226.3"
                     /tool="antismash"
                     /translation="DIINMSVGEPDLHPPLTASYAGIQAIVKGKTGYTPAAGLIELRES
                     IVRYLLNERGLEYKPNQIIASAGGKQPLYNVFQAICDQDDEVILPSPYWVSYPEQIKLS
                     GAVPVIVSCDETTNFKITPEKLAEVITPKTKAVVITSPNNPTGSVYSENELKALGNVLK
                     DYSEIFIISDEIYDQFVYEGKHISLPLIFPELLNRTIITNGFSKVFAMTGWRLGYIAAP
                     SDIAEAIASFQSHATGSPSTISQYAGISALNGFDKSMVEEYKKRRDILVDGLNQIEGIQ
                     CAKPNGAFYAFPNVSQFFGTMFEDQQIIDAETFCHLLLEKQHVSAVPGTAFGEPNNIRL
                     NFAIPKDLITEALKRI"
     CDS             complement(6258..7142)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: phosphonates"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: PEP_mutase"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) phosphonates-like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1231:carboxyvinyl-carboxyphosphonate (Score: 264.8;
                     E-value: 1.5e-80)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg29_223"
                     /sec_met_domain="phosphonates (E-value: 3.5e-109, bitscore:
                     358.3, seeds: 8, tool: rule-based-clusters)"
                     /sec_met_domain="phosphonates-like (E-value: 2.1e-127,
                     bitscore: 417.8, seeds: 13, tool: rule-based-clusters)"
                     /sec_met_domain="PEP_mutase (E-value: 1.4e-68, bitscore:
                     225.0, seeds: 69, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKNRKSSIFRDALNSKGLVKVAGAHDGLSAKLAEKNGFNAVWASG
                     LGISAVQTVPDASILTMTEFLEAAVIMNESCNLPVIADCDSGYGNIHNVTRMIKKYEAA
                     GIAGVCIEDKVYPKLNSFDDRQQILVSTEEFCAKIRAAKMAQQNDDFVLIARVEALIAK
                     LGQEEAYTRAKAYVHAGADAILIHSKEQSPDEIIEFVNNWDVDAPLVVVPTKYPTLSME
                     QLEKLGVKVSIYANQALRASVKAINDTFESIINNKSSLQIENDIVSVNEIFDIQDVPGM
                     KQLERLIHRQPAN"
     CDS             complement(7157..8368)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ATP-grasp_3"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) RimK"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Dala_Dala_lig_C"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ATP-grasp"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg29_224"
                     /sec_met_domain="ATP-grasp_3 (E-value: 1.6e-16, bitscore:
                     54.8, seeds: 15, tool: rule-based-clusters)"
                     /sec_met_domain="RimK (E-value: 9.6e-07, bitscore: 22.6,
                     seeds: 4, tool: rule-based-clusters)"
                     /sec_met_domain="Dala_Dala_lig_C (E-value: 7.7e-11,
                     bitscore: 35.9, seeds: 12, tool: rule-based-clusters)"
                     /sec_met_domain="ATP-grasp (E-value: 5.2e-10, bitscore:
                     33.2, seeds: 20, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MERKRLFLIGIPETHIEKAVTRAKQLGFDVLLGDTEASLKKYEHL
                     IKEADQKIALDYTNHENLFSVAKEIHDKEPLDAIFTFKEAGLFNVSKLQQAFHLKGNPP
                     SVVQACLDKYTTRRLLKKAGLNSPDFGLCRSVEDVYDFWNTSQHPIILKPRSQQGSIGV
                     IKVEKKEDIEACFKECSKHDEEKSVLAEEFIEGQEISIEAVVCQGKVDIFGVTEKLLYP
                     GTFVESGHISPYKHKEKHQDLYKNLVKEVVHAMGIVFGPLHIEGYHTNKGFVVGEVHTR
                     YGGDNIVTITEIAMKCDMHTPIFAELAGIPYQPERKHAQSEVCAVRFLETNQGVVRAIK
                     GISDLKMMGNVVDFHVNCSVGDRIRPIKNSYDRAGWMIVKGKNEREVNHALHDAIDKIK
                     IIIR"
     CDS             complement(8331..9593)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ATP-grasp_3"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ATP-grasp"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Dala_Dala_lig_C"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1063:argininosuccinate lyase/adenylosuccinate lyase
                     (Score: 72.2; E-value: 7.2e-22)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg29_225"
                     /sec_met_domain="ATP-grasp_3 (E-value: 8.8e-14, bitscore:
                     45.9, seeds: 15, tool: rule-based-clusters)"
                     /sec_met_domain="ATP-grasp (E-value: 7.4e-09, bitscore:
                     29.4, seeds: 20, tool: rule-based-clusters)"
                     /sec_met_domain="Dala_Dala_lig_C (E-value: 1e-07, bitscore:
                     25.7, seeds: 12, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MEKHILFFNATYIKKISTLETAKNLGLTVSVVGPELPEWSRPFVD
                     HYISANTYQIDETIAVLKETAKENPFDGVITFWDRDVVPVAVTARELNLKGSPVEAAER
                     ARNKWKMRQFLNRAQVPHPKYCKFTNWTELYHASIDMEYPLIVKPVGASASKGVFRISK
                     PEDLNRAYQQLLNAAVPENDKMFSFYQNEYIVEEFMNGQEVSIEGVISDGVIHFAGVTE
                     KWTDQYFEEYQHAFPARLPEAVERELFHITSEGIKALELNNCGFHAEVMITEKGCKIIE
                     INGRLGGDFITTHLVPLAKGINITRANLLAVLGETISFEASKRRAACVRFLIADRAGVI
                     EKWEGVESIKEMPGVVEFVLEKQPGDHVGLPPEKFHDSRIAYVITEAEDTEKAIEYAEN
                     ALSEVRCFINGEEKTVPDRDS"
     CDS             complement(9957..11507)
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1249:carbamoyl phosphate synthase small subunit
                     (Score: 384.9; E-value: 5.4e-117)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg29_226"
                     /transl_table=11
                     /translation="MTTMTKLVNEMILVLDFGSQYNQLITRRIREFGVYSELHPHTLTA
                     EEIKEMNPKGIILSGGPNSVYDEGSFRCDEKIFELDIPVLGICYGMQLMTHYLGGKVEA
                     ASQREYGKANIQIQGTPDLFKDLPEEQVVWMSHGDLVVQVPEGFTVDATSHHCPNSAMS
                     KKDKKWYGVQFHPEVRHSEYGNDLLKNFVFGPCECKGEWSMENFIEIEMQKIRETVGDK
                     QVLCALSGGVDSSVVAVLIHKAIGDQLTCIFVDHGLLRKGEAEGVMKTFSEGFNMNVIK
                     VDAKDRFLNKLKGVSDPEQKRKIIGNEFIYVFDDEADRLKGIDYLAQGTLYTDIIESGT
                     ATAQTIKSHHNVGGLPEDMQFELIEPLNTLFKDEVRALGTELGIPDDIVWRQPFPGPGL
                     GIRVLGEVTEEKLEIVRESDAILREEVANHGLERDIWQYFTVLPDIRSVGVMGDARTYD
                     YTIGIRAVTSIDGMTSDWARIPWDVLEVISTRIVNEVKHINRVVYDITSKPPATIEWE"
ORIGIN
        1 gccggagccg tcacattcgt ggtgacaact gacagaagcg gcgagaaaaa catcgccagc
       61 aaaaagagaa tgcccgtcac aacagccgcg aagccggagc gcgcccccgc cgcaacgcct
      121 gagctggatt caacataaga agtcgttgta gacgtaccga gtacggctcc gataacgatt
      181 gatgtcgaat ctgccagaag cgctcttccc gcacgcggaa gtttgttttc cttcatcagc
      241 ccggcctgtg tcgctacagc caccagcgtt ccggccgtat cgaaaaaccc gacgaacaag
      301 aaagttaaaa tgacaatcag catttggacg gagaagatat ccggaagatg catccacgcc
      361 tgtccgaaag tcggcgcaag actcggcacg ctgccgacaa tgtgcgtcgg aaccggaatc
      421 agtccgcaga ccatgccggc aaccgccgtc agaagcattc cgataaatac gccgccgttt
      481 acgcgaagca ccatcagaat gacagtcaca ataacaccga aaaccgtcag cagcacaggg
      541 ccgctgtgaa tattgccgat agacaccaga gtcgatgagt tcgcttcaat aatgcccgaa
      601 ccctgcaaac cgacaaatgt gataaacaaa ccgatacccg cgccgaccgc caatttcagc
      661 tcaggcggaa tcgcattaat gattttttcc cgcagtcccg tcagcgaaag cgccacgaag
      721 ataattccgg aaatcaagac gccggaaagc gcagcctgcc atgaaatccc catgccgagg
      781 acgacagaga aagcaaaaaa cgcatttaat cccatacccg gcgcaatcgc gatcggatac
      841 tttgcaatga gccccattaa aatacagccg gccgcagacg ccaaggctgt agcggtgaac
      901 accgcgccct gatcaatttt taatgcttcc ggaaatccct tcacaccgtt taaagacaat
      961 gtcagcggat tgacgaacag aatgtacgcc attgacaaaa aggtcgttaa accgccgatg
     1021 atttcattac gatagcttgt ccccagctca tcaaactgaa aaaattgctt caagccaatt
     1081 gcctccttca ttctctccca tttattctgc ccgttatccg ccaaataaaa aacgccccaa
     1141 atacatttgg gacgcttgac tacatacgtt cagtctgaat aaataagaat ggattattta
     1201 tatcaaacga ttgagattga tccgtagtca agccatttac ggtagcttgg tagaaacttg
     1261 cgggccatat ccccgccatt atacgatatc tgcatatttg atttctgagt ctattgtatc
     1321 aattcaattt tgaaaactca ataaaaaaaa cgaacaatcc cgttaaaaaa atttggttta
     1381 ttcgttaatt gaccaaaaat ggaagacggc aaaagccgcc ttccagacat cattttccgt
     1441 ccgcaggccg aaccggcacc gcgaatgtga tccccttatc atccgccagc aagttcataa
     1501 ccgtttgatt gacgtacaaa gcgtatgaat cgaatgagaa atcgcgcaac gaatagtctt
     1561 tatcggttga atcatctaat tcaaaaacgg attccatttc acccgtttta aggttcgtga
     1621 ctttcgcctt attccctttc agataatagc ctttttcata ctcattaagc gatggccagg
     1681 ttttcatttt tttcgtattg ccgagaccga ttgactcacc gacattgatc agctgatctt
     1741 catccgcctt gctgtaattg attccggtga attgataatc gacgattacc gttctgcctt
     1801 gctgtttgat ctttttgatg gtaatgccga catgatgatg tttcgtttta taactgacgg
     1861 gcagttttgt tttcagaggc acgatttctc ccggctctga ttctgttttt atatcgcccg
     1921 ttatgaaaag tgttttcgct ttcgggtcta tcggtttgct gaattgagtt tggccgcgta
     1981 ttcttttccc gccgccggga agattctttc tgccgccaag ttcaatattc gacgccgtca
     2041 tttcataatg gtttccggca tcatccgttg cctcgtaaat cgagatggca tcatttttgg
     2101 ctgcatcata gaagtcgata gaatacagga gagccgatcc cgtcgttccg ttttccgccc
     2161 ggatatcgaa aaagcggtat aatccgtgat ttacattcac agctttcgtt ccttccagag
     2221 aaacggactt ttgtttttta atagggagtg taaagcgcca gtttcccggg atgtccttga
     2281 tttttgtaat gacaagcgga agcttatcac cgtctttcag ctttgagccg tccgtgaaca
     2341 ggcgaagctg tcccgcgtac cgtccgtctt tcattttttt catatcactg ttgtcataat
     2401 cctctgctaa catattccat ggatctttat aatcaacttg aaaagagatg ctctcctcat
     2461 ctgatttcaa attgtcaacg gtaaaattgt aaacgagctg tccgctgtcg taatacacac
     2521 ttttcactgt caccgtgatt ccgcgtgatt ccgctttctc attcagtttt gtcaccaaat
     2581 tgcttttaaa cagcgcagaa cctgccttat cctgaaacag actgtaaatt tgtccggcaa
     2641 caggaatgtt tcccatagcc gtattaacgg agggcatgaa taagcctgag gacagataca
     2701 gaataaacaa agctgcagca accgcaagtc cgtttatcac ttttcgtccc catctccgtc
     2761 tgacagcgcc ttcttttccg gcacggacag cggcgctgtg tatcacattt ttcaattcag
     2821 ctttcggcac gtcaatgtcc tgatacaatt gcttcatttg atgcttttcc atatatgttt
     2881 atcctccttt tccagctcct gtttcaatgc ttttctcgcc ctgtgcagat gcgtttttac
     2941 agtgccttcc gccataccgg tctgttcagc gatcatagca atcgagaaat cttgaaaata
     3001 ataaagctga atggtcagct gtatatgttc gtcaagcgtt tccagggcat tccgaagatc
     3061 tatgtattct tcaatgttct tattctccgc gcgcgtatca tgctgcggct caaacgggat
     3121 gacgtctccg tgctttttct tcatcgcaaa aatcgtatga agcaaaatcc ggatcagcca
     3181 cgttttaaaa tatttcggct ccttcagctg cgcgatatga agaaaagcct tgtaagccgt
     3241 ttcctgaaca gcgtccagcg tatcttcctt gtgatgcaaa tagagataag ctgttttata
     3301 taaagtatcc tggtgtgctg tgatcagttt ttcaaaggct gcggcatcac cttttttcgc
     3361 ctttttgatc aatcgttctt ccttcacctt atccacctcc tatgctgtta gatatgaatc
     3421 aaggcaaaac ggtttcaaaa agatgaaaaa aaacgcctca aagtctaatt tcggataaca
     3481 acgatccgtt ttcaaactga aggtgttttt tgtttgtctc atcttatggg gtcagtccct
     3541 tagattaata ccttctttgt ttgccgttca gtctgtattc ctctccccaa aaatataaac
     3601 actcttgttt cccattctga tggggcgctg ctgaaaagaa aaaagccttt aaacctttga
     3661 ggttcaaaga ctttgccatt aattcttcat tgtgttaaaa catttaactc ctatgagatt
     3721 ctgttacatc aacttttgaa tgtccgctct tatcaagatg tttttttgcc aaaaataaaa
     3781 ccggaattcc cgaggctgtc gttataaaaa tgatcaaaaa catatagaag gacccgttta
     3841 caccaaaaaa ggaaagaaga atccctccca gccaaggacc gattacattt cctaaacggt
     3901 taaagcctgc tgctccaaag tatgtccctt tgaagcctgg ttttgcaatt tcatccacca
     3961 gcatatcaac catcgaaaaa atcaaaactt cccctattgt gaaaaacacg acgatagagc
     4021 cccatatgaa tgggttggac gatagcgaaa aaaataataa actgaaacta attaaagcat
     4081 ttcccagaat gattgaatga atcggcggga actttttcat gatattcaca atagggtatt
     4141 gaacaattaa gacgacaatt gcattcaaag ctaaaagcca tgaaaatatg gtcaccccgt
     4201 cctctatttt ggcggcaaaa tattggggca atgttgtaga aaagtgcgca tatccggata
     4261 ttgataatat cactccaagt aatgtgataa gaaaaacctt gtctttcctt gtcacattaa
     4321 aggccgtagc aatagtcgtt ttattttctt ttcgattgtt ctcgtctaat ttaaattttc
     4381 ggaatgaaaa taagagagat agaccataaa gaaaatatgt aaaacctgcg aacagaaatg
     4441 ggagagccgt cttggcagct cccaatctaa ggcctaaaag aggaccgaaa actacgccga
     4501 tattaatcgc agtataccgc aaattaaaca tcttcaaacg attttcttct ttgcttatat
     4561 cggataataa tgctcttgac gccggttcaa agatagattg acacagcccg ttaagcgcat
     4621 tgatgacaaa aaatgcgagt acactatctg caaacataaa acttacaaaa acaagcgccc
     4681 aacaaaatac agacgttatc atcacaattt tcctgccaaa aagatcagac aaataccctc
     4741 cgtaaaagct cattacaatc ccagccagcg aacttactga aacaatgatg ccggttaaag
     4801 caggagaaac accttttact tgtgttaggt aaatagaaag gaagggaatg ctcatcgaga
     4861 ctgacattct gctaaacaag gtgcctaaaa tgatattcca gcccacaggg tgaattctta
     4921 atcgtatgcc tttcaaaaaa ccacctgcct aaacattaga tgcagatata aagaggctcg
     4981 tttaagcttt cagcgctctg ttatacctta actgccagct gagttgtaaa attattaatt
     5041 cttttcaaag cctctgtgat aagatccttt gggatggcaa aattcaaacg aatgttgttc
     5101 ggctctccga atgctgtgcc gggaacagct gacacgtgct gtttttccaa cagaagatga
     5161 caaaatgtct ccgcatcaat tatttgttga tcttcaaaca ttgttccgaa aaattgtgaa
     5221 acattcggaa acgcataaaa ggctccattt ggtttggcgc attgaatgcc ctcaatttga
     5281 tttaaaccat cgactaatat atcgcgtctt tttttgtatt cttcgaccat cgacttgtca
     5341 aaaccgttta aagcagaaat accggcatat tgagaaatag ttgacgggct gcctgtagca
     5401 tggctttgaa agctggcaat ggcttcggct atatccgatg gggctgcgat atagccgagc
     5461 ctccatccag tcattgcaaa gactttggaa aatccattcg ttatgatggt ccgatttagc
     5521 aattcgggaa aaatgagcgg cagactgata tgcttgccct catacacaaa ctgatcataa
     5581 atttcgtcgg aaatgataaa aatttcagaa taatctttca acacatttcc taaagctttc
     5641 agttcatttt ctgaataaac ggaccctgtc ggattattgg gagatgtgat aacaacagct
     5701 tttgtcttag gggtaattac ttctgcaagc ttctcgggtg tgattttaaa atttgtagtt
     5761 tcatcacagc ttacaataac aggaaccgcc cccgacagtt tgatttgttc cggataagat
     5821 acccagtaag gtgaagggag gataacttcg tcgtcttgat cacaaattgc ttgaaaaaca
     5881 ttatatagcg gctgttttcc cccggcagat gcaattattt ggtttggttt atattctaaa
     5941 cctcgttcgt taagcagata tcgcacaatg gattctctta attcaatcag ccctgctgcc
     6001 ggcgtatacc cggttttccc cttcactatt gcctgaattc ctgcatatga ggctgttaat
     6061 ggcggatgaa gatccggttc tccgacactc atatttataa tgtcttttcc ttcttttacc
     6121 attatcttcg ttttggcatt taatgacata gtggccgaag gttttatatt catgactcta
     6181 tcggataatc ttttattcaa ttcaaacgcc tccaatgtct ttatgggcca ttcttaaaat
     6241 agcacgatac aaaaacctca gttagccggc tgtctatgga tcaaacgctc cagttgcttc
     6301 atccccggaa cgtcttgaat gtcaaatatc tcattaacgc tcacgatgtc attttcaatc
     6361 tgcaaagacg atttattatt tataatgctt tcgaatgtat catttatagc cttaacagaa
     6421 gcgcgcaacg cctgattcgc atagatggaa accttcactc ccaatttctc aagctgttcc
     6481 attgagagcg tcggatattt agtcggaacc acaaccaacg gcgcatccac gtcccaattg
     6541 ttaacaaact caataatttc atcaggcgat tgttcttttg aatgaattaa aattgcatct
     6601 gctccagcat gaacataagc ttttgctctt gtataggctt cttcttgacc caatttagca
     6661 attaaagctt cgacacgggc aatcaataca aaatcgtcat tttgctgagc catctttgcg
     6721 gctctaattt ttgcgcaaaa ttcttcagta ctgacaagga tctgttgtct gtcgtcaaat
     6781 gagtttaatt ttggatatac tttatcttca atacaaactc cggcaatacc agcagcttcg
     6841 tattttttga tcatgcgggt gacattgtga atgttcccgt agccggaatc acagtcagcg
     6901 atgaccggca aattgcatga ttcattcata atgacggcgg cttcaagaaa ttcagtcatc
     6961 gttaatatac tggcatcagg tacagtttgc acagccgaga ttcccaaacc gcttgcccat
     7021 acggcattaa atccgttttt ctctgctaat ttggcgctta aaccgtcatg agctcccgca
     7081 actttcacca aacctttact gtttaaagca tctctaaaaa ttgatgattt tctgtttttc
     7141 accatcattc tccccttcac ctaatgatta tttttatttt gtcaatcgca tcatgtaatg
     7201 cgtgattgac ttctcgctca tttttcccct ttacaatcat ccatcctgct ctatcgtagc
     7261 tgtttttgat cggtctgatt ctatcaccga cactgcaatt tacatgaaaa tctactacat
     7321 tccccatcat tttgagatcg ctgatccctt tgattgcgcg tacaacccct tggttcgttt
     7381 ctaaaaaacg aacggcgcat acttcgcttt gagcatgttt cctttccggt tgatatggga
     7441 tgcccgccag ttccgcaaaa ataggtgtat gcatatcaca tttcatggcg atttctgtaa
     7501 tggtcactat gttgtctccg ccatagcggg tgtgtacctc gccaaccaca aatcctttat
     7561 ttgtgtgata cccttcaata tgcaaggggc caaatacgat ccccatggca tgaacaactt
     7621 ccttgaccag attcttatac aaatcctgat gtttttcttt atgtttatac ggcgatatat
     7681 gcccagattc tacaaaagtc ccggggtata gcaacttttc ggtcacacca aatatgtcga
     7741 ccttgccttg gcagacaacg gcttctattg aaatttcctg cccttctata aattcttcgg
     7801 ctaatactga cttctcctcg tcatgttttg aacactcttt aaaacacgcc tcaatgtcct
     7861 cttttttctc aacttttatg acgcctatac tgccttgctg agatctcggc tttaaaatga
     7921 taggatgttg agatgtattc caaaaatcgt atacgtcttc cacgctcctg cacaatccaa
     7981 aatcgggaga gtttagtcct gcctttttta aaagccggcg cgttgtatat ttatcaaggc
     8041 atgcttgcac cacagacgga ggatttcctt ttaaatgaaa tgcctgctga agtttggata
     8101 cattgaataa gccggcttct ttgaaagtaa atatggcatc taaaggctct ttgtcatgga
     8161 tttctttagc gactgagaat agattctcat gattggtata atctaatgcg attttttggt
     8221 cagcttcctt tattaaatgc tcatattttt ttaatgaagc ttctgtatct cctaataaga
     8281 cgtcaaaacc aagttgtttt gccctcgtaa cggccttctc aatatgcgtt tcaggaatcc
     8341 cgatcaggaa cagtcttttc ctctccattg atgaaacacc tcacttcaga taaagcattt
     8401 tcagcatatt cgatcgcttt ttctgtatct tcggcttctg tgatgacata agcaatccgg
     8461 gaatcatgaa acttttcagg cggcaggcca acatgatcgc ccggctgctt ttctaaaaca
     8521 aattcaacga ccccgggcat ttctttgatc gattcgacac cttcccactt ttctatcaca
     8581 ccagcacggt ctgcaattaa aaacctgacg caggcagctc ttcttttcga agcttcaaag
     8641 cttattgttt ctcctaatac agccaatagg tttgcgcgcg ttatatttat acctttggct
     8701 agaggaacca aatgggtagt aataaaatcg ccgcccagac gaccgttgat ctcgataatc
     8761 ttgcaccctt tctctgtgat catgacctcg gcatgaaaac cacaattgtt cagctccaaa
     8821 gcttttatcc cttcactggt gatgtggaat aattcacgtt ccacagcctc cggcagcctg
     8881 gcgggaaatg catgctggta ttcttcgaaa tactgatccg tccatttttc agtaacacct
     8941 gcaaagtgaa tgactccgtc ggaaatcact ccctcaatgc tgacttcttg tccgttcata
     9001 aactcttcaa caatatactc gttttgataa aaagaaaaca ttttatcgtt ttccggcacc
     9061 gcggcgttta acagctgctg atatgcgcga tttaaatctt caggctttga tattcggaat
     9121 acgcctttac tggcagaagc acccacaggt ttaacgatca atgggtattc catatcaatg
     9181 cttgcatgat ataattcggt ccaatttgta aatttgcaat attttggatg aggaacttgt
     9241 gcgcggttca aaaattgacg catcttccat ttgtttcgag cccgttctgc cgcttccacc
     9301 ggactgccct ttaagttaag ttctcgggca gttaccgcca ccggaaccac atctctatcc
     9361 cagaatgtaa tgactccatc aaaaggattt tctttggcag tttccttcag aacagctata
     9421 gtctcatcaa tctgataagt atttgcggaa atgtaatggt caacgaatgg ccgcgaccat
     9481 tcaggcagtt cagggccgac aacagaaacc gtcaagccca aatttttagc agtctccaaa
     9541 gtagaaattt ttttaatata agtagcatta aaaaataaaa tatgtttttc catccttccg
     9601 agcctctttc aacatttttt tctacaaatt agaaaccttc tgcgtttcta aagaactgaa
     9661 tgcagaagat aaaaaaaccc cttggaaaac acaaaccatc atatgtttta tttgtatata
     9721 ttcataataa catacattat ttgttattaa atgaatattt tatgaattca gttttattag
     9781 aaaaattgaa attataggga gaatattagg aatacaactg attaaaaaac tcgaatatat
     9841 aaaaaactgc tgcacatctt ctccggtgtt aatgataaaa ggcccattat tcctagaacc
     9901 atgtaaatta aaaaagcctc aaatctttat aaataaaaga tttgaggctt ttctcattat
     9961 tcccactcaa ttgttgcagg cggcttgctc gtaatgtcat acacgacgcg gttgatgtgt
    10021 ttcacttcat tgacgatccg tgtcgaaatc acttcaagca catcccaagg gatacgcgcc
    10081 cagtcagatg tcatgccgtc gattgatgtt acggcacgga taccgattgt gtaatcatac
    10141 gttctcgcat ctcccatgac gccgacgctg cggatgtcag gaagaaccgt gaagtactgc
    10201 cagatgtcgc gctcaaggcc gtggttcgcc acttcttcac gcagaatcgc gtctgattca
    10261 cgaacgatct caagtttttc ttccgttact tcgccgagta cgcggatgcc aagtccagga
    10321 cccgggaacg gctgacgcca tacgatatca tccgggatgc cgagctctgt gccgagcgcg
    10381 cgcacttcat ctttgaaaag agtgttcagc ggttcgatca gttcaaactg catatcttca
    10441 ggaagtccgc cgacattgtg gtgcgatttg atcgtttgcg cagttgccgt tccgctttca
    10501 ataatgtctg tgtaaagcgt tccttgcgca aggtagtcga ttcctttcag cctgtccgct
    10561 tcatcatcaa atacgtaaat gaattcgttg ccgatgattt tgcgtttttg ctcaggatca
    10621 gaaacacctt tcagcttgtt taagaatctg tctttcgcat caactttaat gacattcata
    10681 ttaaagcctt cgctgaacgt tttcatgacg ccttccgctt cgcctttgcg gagaaggccg
    10741 tgatctacga aaatacaagt cagctggtcg ccgatcgctt tatgaatcaa aacggctacg
    10801 acagaagaat cgactccgcc gctcaaagcg caaagcactt gtttgtctcc gacggtttcg
    10861 cggatttttt gcatttcgat ttcgataaag ttttccattg accattcgcc tttacattca
    10921 caaggcccga agacaaagtt tttcagaagg tcatttccgt attctgaatg acggacttcc
    10981 ggatggaact gaacaccgta ccattttttg tcttttttgc tcatcgccga gttcgggcag
    11041 tgatggcttg tcgcgtctac cgtaaaccct tccggcactt gtacgactaa gtcgccgtgg
    11101 ctcatccaga caacttgttc ttccggaaga tctttgaaca agtcaggagt tccttgaatc
    11161 tgaatgttcg cttttccgta ttcgcgctgg cttgccgcct cgactttccc tccgaggtaa
    11221 tgagtcatca gctgcatgcc gtagcagatg cctaatacag gaatatcaag ttcaaagatt
    11281 ttttcatcac agcggaaaga cccttcatca tatacactgt ttggtccgcc tgaaaggata
    11341 attccttttg gattcatttc tttgatttcc tcagctgtca acgtatgggg atgcagctcg
    11401 ctatatacgc caaattcacg gatccggcgg gtaatcagct ggttatactg actgccgaaa
    11461 tcaagaacaa gaatcatttc attcactaac ttcgtcatgg ttgtcaccta atctcctcta
    11521 agtttttgac acagaaaaaa cggaggacac acgttcagcc ctctgtcggc aagacttgtc
    11581 cggaagcccg gctttttaac gctcccgggc tcccatttaa cattcattta ttctaacaac
    11641 aggacgatat gcggtcaaga ctatcttctt ttaattatat tttcccacaa ctgtcccgat
    11701 tcattccaaa gctttgcggc attatcgctg cggtataacg cacgctcata gcgcagcgtc
    11761 agctcggaca tgtcgtttgt atggtgcgcc tcgtcaaccc tcgcggcaaa atcacggagc
    11821 gtttctccgt ctcccctgct gaaccctttt cgtttcagct gtcggagcag tgcggcatat
    11881 gcgtcgaaaa agacgtcttc atccgttcgc cgcttcaatc tggctgctgt aacgtgcgga
    11941 atccagcgcg cccggagcag ccaggcgagt gccgccgcgg ctgaaatcac aatgacgatg
    12001 gctgcatacg gccatagctg tgccgcggtt ttgttgcgga tcacaggctg cggtgccgcg
    12061 ctgtgatccc gctttttcgg cttttcctct ttttccggct ttgtttcctg acgctgcttg
    12121 tcagacggtt catccgagtt cc
//
