LOCUS       c00023_gnlPro..        23249 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|ELDFHDME_28.
ACCESSION   c00023_gnlPro..
VERSION     c00023_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-04 02:10:37
            Original ID  :: gnl|Prokka|ELDFHDME_28
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 11016
            Orig. end    :: 34265
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..23249
                     /aStool="rule-based-clusters"
                     /contig_edge="False"
                     /core_location="[21016:24265]"
                     /cutoff="10000"
                     /detection_rule="(minimum(2, [AdoMet_dc, Spermine_synt_N,
                     Spermine_synth]) or (Orn_DAP_Arg_deC and Sacchrp_dh_C))"
                     /neighbourhood="10000"
                     /product="Putrescine2spermidine"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      10001..13249
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(minimum(2, [AdoMet_dc, Spermine_synt_N,
                     Spermine_synth]) or (Orn_DAP_Arg_deC and Sacchrp_dh_C))"
                     /neighbourhood="10000"
                     /product="Putrescine2spermidine"
                     /protocluster_number="1"
     cand_cluster    1..23249
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(minimum(2, [AdoMet_dc, Spermine_synt_N,
                     Spermine_synth]) or (Orn_DAP_Arg_deC and Sacchrp_dh_C))"
                     /kind="single"
                     /product="Putrescine2spermidine"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..23249
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="Putrescine2spermidine"
                     /region_number="1"
                     /rules="(minimum(2, [AdoMet_dc, Spermine_synt_N,
                     Spermine_synth]) or (Orn_DAP_Arg_deC and Sacchrp_dh_C))"
                     /tool="gutsmash"
     CDS             complement(143..1234)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peripla_BP_3"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1043:Periplasmic binding protein-like domain (Score:
                     107.3; E-value: 3.4e-33)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg23_12"
                     /sec_met_domain="Peripla_BP_3 (E-value: 4e-33, bitscore:
                     107.3, seeds: 83, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTDNGKPKYFSLMEQLRSDIMSGAIRPGEKLPSENELSQKYSLSR
                     HTVRKALGILEQDGYVEAFHGRGTYCSENMRHIKNSKNIAVVTTYISDYIFPRLIQGMD
                     NVLSESGYSIILKNTANSRQKEARCLEELLKKDIDGLIIEPSKSEMICKHRNLYQNLDK
                     FEIPYVFIQGIYSEMRDKPHILMDDAQGGYLVTKYLLELGHKKIKGFFKADDMQGLERH
                     KGYVKALQESGIAYDPDDVVWFHTEDRKVKPALMAKEMVQSGQLPDGIVCYNDQIAVQV
                     MEELEKMGVRIPDDISITGYDNSLYAQRGSGITTIAHPQEKLGEMAAELILEKINGVPE
                     EESKVERLIYPELIIRGSCRKIL"
     CDS             complement(1426..2313)
                     /locus_tag="ctg23_13"
                     /transl_table=11
                     /translation="MKKLRTFAVSMIIAAIGLLIYCAGFYIKSYEQNLAARQEYAELSQ
                     MAGVKNREGAGLLADGKKTDEDSSTKNSEKKRRKKQRRSSESKNKNCTDEIRESFGISW
                     ENLRKINSQTVAWITVPGADISYPVVQAADDEYYLKHNFRGEEDLFGCIFLEHDIKKNF
                     TDSHSILYGHNIEGNMMFANLNRYEQPEFLKKCPEIEITTPKRKFLYKIFSVEQASSQS
                     PAFEYGYKLSSPAYRRQLSILKNNSMYDTGVEPDERERMVTLITCNSRLDKEIRMAVHG
                     ICHECYGIEKAGPK"
     CDS             complement(2310..7019)
                     /locus_tag="ctg23_14"
                     /transl_table=11
                     /translation="MKHNFKLKERLGALLLAMLFILQAILGLVPVCVTQAAPLTVETWD
                     SDKVVDYGYRFNMKFQPGITTYESFGCDNLDREAFSDNGKSERDTECVRVGADYKAGSA
                     GMRYNNVGKDGNGNIVDVRLILVGVENAEPRYDLRTAESIVQNKGGATFAWKDNEAYPM
                     VGFSKNSIGVFIYSVGYAKVKFQFLKHGTEETLPISGHGTIRDIDAGQGVRIPSDSSLD
                     NAYVLKNNDYLTVDGNSVSSPLGSVEPDDPRGWLNLFYNTDNFTVEFCHQFRLDKWDKS
                     REDAIAKAGSQERWAEITRNKYLDPSGNSYCPNFKGQKYCKAYAYFDFTSYCFGDVEMK
                     KAPEKRVGEANCTWEQAAAASKEKPFGIRQGQEFQYMIRAEVTPNRLKSFVVQDILEDC
                     LTIEDASKVSIVNDAGQTVTDWFDVAVEGQKVTCRAKAESLQDEAFTDNQTYTFTLKVR
                     QRPESEINISKYLAEDGYSILVPNHASMSYERTNGSGDTMDTETVWVKGVIPPELEVKK
                     NTSQYEWKTGDIIDYEVLVSQTKQDVKAVNVVITDELPSCLQLLEGQYAVETSQGGENC
                     TLTGQGENGWKAECPSLKYGETITIRFKCQASADSNGQEWENIVTATADNLINPDTGEQ
                     ESRKDMAEVWPNSPQLEIDKTADKYEWQAGEQVAYRIVVNNVTAGTIAKDVTITDIGLP
                     QGLVLAGGTQSMEVLGVQQQVNYPVPDKKTGQAYEARPVDSQLNADENGFSFYCSYVPY
                     SQPVTIIFHCIAQEEANGHESVNAATVKAVNTDERSDDAEVYVNSGEFWIEKSADHYEW
                     QVGEQVQYNVVVENKKAGTVARNVTVWDTGMPAGLALSSAEDVSVSGIPQNITQLTAGT
                     KDVLNQLNPEFYNETSEKPVNYEFLQEGSGWRLNISDLPANTPVMISFLCTVTEAANGM
                     ESINVANVQAQNAPVSQDDAEVYVNTAVLSIEKSFQNPYLAAGDGRAENEFRVGEQVNY
                     QVTVNNLQKGSIARNLVISDLSLPEGLALDGAEDAVTVSGVPAVIQNPVAGTDDAGNQL
                     NPENYKETVEKPVSCQVTRQGTGWIVTISDLPYQTPVTVNFRCTAQESVNGMEIVNTAQ
                     AYADNAQKVKDSSKIWVNSPVLKVEKTTDKPFYKYGDIITYRIVLTQEQTGCVARNVTL
                     QDVIDTQGVRLLKDSVILMDEKGNVADADVQINDDNTFLMSTGRTLVRDSRYSICDNDK
                     GGLFEQVIYNPLDCQEQKSMIVEYQAAVIDAALAGQKVHNTAVADSSEKIPATGEAETE
                     VHSPILEIVKESDKKEYASGEKGYYKLTVRQLREDVTDQNIVIEDKLETQGASIVKDSI
                     FVKKNGIELKDAKIEADDTGFVIQTGASLSDMDKIEVCYEMVFKTESTEPEKIVNTAKA
                     RGDISPEITAQQEAYVKAKAEPTATPTPSATPKPTETPKPTETPKPTEVPKPTEQPKAT
                     PTPSVPGTCPKMTPVPTKAPLASYNGGNNGGTTSGSGGSSYANSGGYSGGYGSYQGGSM
                     AGSSKTGDVRPFKMMAVLGLIGMGLLTGGVVIYRRTVSGKRNIKGMPRK"
     CDS             complement(7223..7684)
                     /locus_tag="ctg23_15"
                     /transl_table=11
                     /translation="MNRKEFLEILRSQLAGQMQEGKAAAHIRYYEDYIQSQVRGGRSEQ
                     EVLQELGDPHLIAKTLIDTDDGSTQEDYGEYSSYGSSYGNETELPHQQEKRWKKVIDLS
                     TWHGRAVVIAAAAVIIVLLILIIGVAIPFFIILAIILYFLSWLKKRNDQ"
     CDS             complement(7884..8762)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) CN_hydrolase"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg23_16"
                     /sec_met_domain="CN_hydrolase (E-value: 1.3e-55, bitscore:
                     180.7, seeds: 52, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRNVTVAAVQMKCSKSVEKNIAHAEELVRQAAAKGAEIVLLPELF
                     ERPYFCQERRYEYYEYAQTAEENPAVRHFSRVAAELGIVIPVSFYEKEVNNTYNSVAVL
                     DADGKNLGVYRKTHIPDDHYYQEKFYFTPGDTGFKVFDTRFGTIGVGICWDQWFPETAR
                     CMALQGAELLFYPTAIGSEPILECDSMEHWRRCMQGHAASNLIPVIAANRIGEETVEPC
                     PENGMQKSALNFYGSSFITDNTGALCAELPGGEEGVLVSTFDLDALKADRLNWGLFRDR
                     RPEMYAKIVGK"
     CDS             complement(8863..9966)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PAD_porph"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg23_17"
                     /sec_met_domain="PAD_porph (E-value: 2.1e-127, bitscore:
                     417.0, seeds: 436, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MEVTEKNRTKYRMPGEFEPHEGCVMIWPERPGSWNYGAREAQKAF
                     VKVAEAIGVSEKVYMLVSKAQMENAKNQLGNVSGVTLLECETDDAWARDVGATMVLDEK
                     GAVCGVDWQFNAWGGDFDGLYRNWEKDDRVAAFICRTLGCPCLDARPFVLEGGSIHSDG
                     EGTLIVTEACLLSQGRNPQMSREQIEEQLKYWLGVHKIIWLPCGIYQDETNEHVDNVCA
                     FVRPGEVVLAWTEDETDPQYAMSLADLKVLEQETDAKGRKFKIHKLPIPQKPVCLTRED
                     VDGFVFEEGEDEREAGERMAASYVNFYISNGGIILPQFGDENDKRAVEILQKCFPERRI
                     YPIDARAIIVGGGNIHCITQQIPGKNI"
     CDS             complement(10001..11122)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Putrescine2spermidine: Orn_DAP_Arg_deC"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg23_18"
                     /sec_met_domain="Orn_DAP_Arg_deC (E-value: 1.5e-14,
                     bitscore: 46.4, seeds: 500, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKIDQLQTPCYVIDEKKMRENLEILKKVQEDTGCKILLAQKAFSG
                     FALYPMIGKYLAGTTASGLFEARLGYEEMGKENHVFSPAYRTEDIEELDRICDHIIFNS
                     TAQLKKFKDVCTRASLGLRINPECSTQGDHALYDPCAPGSRLGVTRENFDGECLKWIDG
                     LHFHTLCEQNADDLEKTLQAVEEKFGEFLSEVSWLNMGGGHHITREDYDVKLLEKCIQH
                     MKETYDLDIYLEPGEAVALNAGYLVTEVMDIVENEIRTLILDASAACHMPDVLEMPYRP
                     PLKDSGEAGEKAYTYRLSSCTCLAGDVIGDYSFDREIRIGDKLYFMDMAIYSMVKNNTF
                     NGMPLPDIAVMHEDGECEVIRHFGYEDFKSRLS"
     CDS             complement(11112..12392)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Putrescine2spermidine: Sacchrp_dh_C"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Sacchrp_dh_NADP"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg23_19"
                     /sec_met_domain="Sacchrp_dh_C (E-value: 2.8e-43, bitscore:
                     141.1, seeds: 375, tool: rule-based-clusters)"
                     /sec_met_domain="Sacchrp_dh_NADP (E-value: 4.1e-35,
                     bitscore: 113.2, seeds: 81, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSRLLVIGCGGVASVAIRKCCQNSDVFTEIMIASRTKEKCDALKE
                     KIESTTKTKIETAKVDADNAAEVAELIRVYKPDAVLNVALPYQDLTIMDACLEAGADYI
                     DTANYEAEDTEDPTWRAIYEKRCKEKGFTAYFDYSWQWAYDEKFKEAGLTALLGTGFDP
                     GVTSVFSAYALKHYFDEIHTIDILDCNGGDHGYPFATNFNPEINLREVSANGSYWEDGH
                     WVETEPMEFKSVYDFPEVGKKDMYLLHHEEIESLAKNIPGVQRIRFFMTFGQSYLTHMK
                     CLENVGMLSTAPVEFNGQEIVPIQFLKALLPDPASLGPRTVGKTNIGCIFTGVKDGKEK
                     SIYIYNVCDHQECYKEVESQAISYTTGVPAMIGSMMVVTGQWKKPGVFNVEEFDPDPYM
                     EALNKWGLPWKVCEDPELVKVWKANED"
     CDS             complement(12389..13249)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Putrescine2spermidine: Spermine_synth"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Putrescine2spermidine: Spermine_synt_N"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg23_20"
                     /sec_met_domain="Spermine_synth (E-value: 2.3e-53,
                     bitscore: 172.6, seeds: 15, tool: rule-based-clusters)"
                     /sec_met_domain="Spermine_synt_N (E-value: 3.4e-15,
                     bitscore: 48.0, seeds: 13, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MELWYSEFHTGNVKLSVRINRQLFSGESEFQRIDVFESEEFGRFV
                     ALDGEIVFSDKDEFIYDEMVTHVPMTVHPNVKNVLIIGGGDGGVARELIHYPQIESIDV
                     VESDKMFVDVCAEMFPDIAQGLKDERVNIYYEDGLRFLRNKKARYDLIINDSTDPLGHT
                     EGLFTKEFYGSCYKALRDDGIMVYQHGSPFYDEDEVECRKMHRKVFRSFPVSRVYQAHI
                     PTCPSGYWLFGFASKKYHPLEDFRPERFDNLNIETWYYTTNLHRGAFMLPKYVEDLLEE
                     EENSL"
     CDS             complement(13252..14709)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) OKR_DC_1_C"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) OKR_DC_1_7_arginine"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg23_21"
                     /sec_met_domain="OKR_DC_1_C (E-value: 1.9e-13, bitscore:
                     43.2, seeds: 113, tool: rule-based-clusters)"
                     /sec_met_domain="OKR_DC_1_7_arginine (E-value: 4.1e-126,
                     bitscore: 413.0, seeds: 39, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDYERQQHAPIYEALERFRKKRVVPFDVPGHKRGRGNPELAQLLG
                     EKCVGLDVNSMKPLDNLCHPVSVIREAEELAADAFGAAHAFLMVGGTTSAVQSMILSVC
                     KAGDKIILPRNVHKSAINALVLCGAIPVYVNPEVNAQLGISLGMEVSQVEKAMDENPDA
                     VAVLVNNPTYYGICSDLRTIVKKAHARGMKVLADEAHGTHLYFGRNLPVSGMAAGADMA
                     AVSMHKSGGSLTQSSLLLLNKSMNAEKVRQIINLTQTTSASYLLLSSLDISRRNLALRG
                     EESFEKVAGMAQYAREEINEIGGYYAYGMDLINGTSVFDFDVTKLSIYTLGNGLAGIEV
                     YDLLRDEYDIQIEFGDICNILAYISIGDRLQDIERLVGALADIERLYKKDSTGMLSGEY
                     IAPAVVASPQQAFYAEKESLPMEQAAGRISGEFVMCYPPGIPILAPGEMVTQEIVEYIL
                     YARDKGCSMQGMEDPKVEHLQVLKGGI"
     CDS             15937..17622
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) FTHFS"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg23_22"
                     /sec_met_domain="FTHFS (E-value: 3.3e-275, bitscore: 905.7,
                     seeds: 408, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MGFKSDIEIAQECEMLPITQIAEKAGIDDKYLEQYGKYKAKIDYN
                     LLKESDKKDGKLILVTAINPTPAGEGKTTTTVGLADGMQRLGKSVMVALREPSLGPVFG
                     VKGGAAGGGYAQVVPMEDINLHFTGDFHAIGAANNLLAAMIDNHIFQGNALNIDPRKIT
                     WRRCVDMNDRQLRNVVDGLGGKTNGMPREDGYDITVASEIMAVLCLASDIKDLKERLSK
                     IIIGYTYGKVSEQKPVTAGDLHAEGAMTALLKDALKPNLVQTLEHVPAIVHGGPFANIA
                     HGCNSVTATKMAMKLADYAITEAGFGADLGAEKFLDIKCRMAGLKPSAVVIVATVRALK
                     YNGGVAKADLNNENLEALEKGIPNLLKHVSNIKNVYKLPCVVAINAFPTDTKAELDFVE
                     AKCKELGVNVALSEVWAKGGEGGIKLAEEVIRLVEEPNDFSYAYELEGSIEDKLNQIVQ
                     KVYGGKKVVLTANAQKQAKQLEALGFGNCPICVAKTQYSLTDDQTKLGAPTDFEVTVRN
                     LKISAGAGFIVALTGEIMTMPGLPKVPAAERIDVDETGKITGLF"
     CDS             complement(17731..19155)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Lyase_1"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) FumaraseC_C"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg23_23"
                     /sec_met_domain="Lyase_1 (E-value: 1.7e-94, bitscore:
                     308.9, seeds: 17, tool: rule-based-clusters)"
                     /sec_met_domain="FumaraseC_C (E-value: 6e-22, bitscore:
                     70.2, seeds: 737, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKKTDYRVERDSIGVKDIPEDVYYGVQSLRAAENFHITGLNMHPE
                     IINSLAYIKKAAAITNCEVGLLEKKKAQAIVQACDEIVSGKFHNEFIVDPVQGGAGTSL
                     NMNANEVIANRAIEILGGKKGDYTIINPNDDVNCGQSTNDVIPTAGKMTSLRLLQNLKK
                     QLLRLYDALNEKATEFDHIIKMGRTQMQDAVPIRLGQEFKAYSVAIMRDIHRMDKAMDE
                     MRTLNMGGTAIGTGINADEGYLRRIVPNLTEISGMDFIQAFDLIDSTQNLDPFVAVSGA
                     VKACAVTLSKMSNDLRLMSSGPRTGFGEINLPAKQNGSSIMPGKVNPVIPEVVNQVAFN
                     IIGNDVTITMAAEAGQLELNAFEPIIFYCMFQSIDTLGYAVQTLVDNCIVGITANEERC
                     RYLVENSVGIITAISPHLGYQKAADIAKKAIKTGESVRSLILKEKLMDEDELNRILDPV
                     HMTEPGISGKDYLIKK"
     CDS             19271..20206
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) LysR_substrate"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) HTH_1"
                     /gene_functions="regulatory (smcogs) SMCOG1012:Bacterial
                     regulatory helix-turn-helix protein, lysR family (Score:
                     58; E-value: 2.3e-18)"
                     /gene_kind="regulatory"
                     /locus_tag="ctg23_24"
                     /sec_met_domain="LysR_substrate (E-value: 2.4e-33,
                     bitscore: 107.5, seeds: 361, tool: rule-based-clusters)"
                     /sec_met_domain="HTH_1 (E-value: 2.7e-18, bitscore: 58.0,
                     seeds: 1330, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MFQGMEYIYEVYKEKSFSKAAAALFISQPSLSANVKRVENRIGYP
                     IFDRSTKPLQLTEVGKHYIQAVEKVMDIENNLENYLLDLGNLKTGTLNVGGSNFFSSWI
                     LPPLIADFSQKFPHVQISLVEESTAKLSQFLQAGKLDLVIDNCILDNQIFERYIYQKEQ
                     LLLAVPKNYSVNTRLQKYQIPIEEIRNGQFRSSHIPSVPLNKFENEPFIILRSDNDTGK
                     RALTICQENHFSPSVVFRLDQQMTAYNIACLGMGITFIGDLLLSRVPTNSELVFYKLPG
                     QSSKRTVFFYWKKGRYISRAMEEFLKLPFS"
     CDS             complement(20318..21775)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) FGGY_C"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) FGGY_N"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg23_25"
                     /sec_met_domain="FGGY_C (E-value: 7.1e-38, bitscore: 122.6,
                     seeds: 64, tool: rule-based-clusters)"
                     /sec_met_domain="FGGY_N (E-value: 1.1e-79, bitscore: 259.7,
                     seeds: 11, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MYYIGIDLGTSAVKLLLMEESGKICNIVSREYPLFFPHPGWSEQK
                     PEDWFIQSMEGMKELTKDIDRTQVAGIGFGGQMHGLVTLDKDDNVIRPAILWNDGRTGE
                     ETEYLNTVIGKDKLSQYTANIAFAGFTAPKILWMQKNEPENFKKVVKIMLPKDYLAYRL
                     SGSFCTDVSDASGMLLLDVKNRCWSKEMLEICGITEEQLPKLYESWEVVGTLKPEIAKE
                     LGFSENVKVVAGAGDNAAAAVGTGTVGDGQCNISLGTSGTVFISSKNFGVDENNALHSF
                     CHADGSYHLMGCMLSAASCNKWWAEEILQTKDFAAEQAPIQKLGENHVFFLPYLMGERS
                     PHNNPDARGVFFGMSMDSTRADMTQAVLEGVAFGLRDSLEVARSLGIKIERTKICGGGA
                     KSPLWKKIIANVMNLKVDVLENEEGPSMGGAMLAAVGCGAYPDVETIGKKFAKVVDTVE
                     PDPELVAKYEERYQKFRTLYPAMKPLF"
ORIGIN
        1 ggaatgctca gcaacttttc ttaagcactc atctccgtaa agatcctgtg aacctgtaca
       61 aaaccagaac ttatagtttc ttcctgtttt catgataaaa ttcctcctag atttattttt
      121 attttttatt tatttcattt gtttacaata tttttctgca tgatccccgt atgatcagtt
      181 ccggataaat cagtctttca accttacttt cttcttcagg aactccgttg atcttctcaa
      241 gtataagctc tgctgccatt tctcccagct tttcctgcgg atgagctatc gttgtgattc
      301 cgcttcctcg ctgagcatac agtgaattgt cataaccggt aatggaaata tcatccggta
      361 tcctgactcc cattttctcc agttcttcca taacctgaac agcaatctga tcattgtaac
      421 agacgattcc atccggaagc tgtccgctct gtaccatttc ttttgccatc agtgcaggtt
      481 ttactttcct gtcctctgta tgaaaccaga caacatcatc aggatcatag gcaatccctg
      541 actcctgtaa ggccttcaca tatcccttgt ggcgctccag tccctgcata tcgtctgcct
      601 taaagaaacc cttgatcttt ttatgtccca gttccagcag atattttgtt acaagatagc
      661 ctccctgtgc atcatccata agaatatgag gtttatccct catttctgaa tagattccct
      721 gaataaacac atacggaatt tcaaatttat ccagattctg ataaagattt ctgtgtttac
      781 agatcatctc acttttgctt ggttcaatga tcagtccatc aatatctttc ttcagaagtt
      841 cctccagaca tctggcctct ttctgtctgc tgtttgctgt gtttttcagg ataatactgt
      901 aaccgctttc tgaaaggaca ttatccattc cctgtatcag tctcggaaaa atataatcag
      961 aaatatatgt ggtcactacc gcaatattct ttgaattctt tatgtggcgc atattctcag
     1021 agcaataagt acctcttccg tgaaatgcct ctacatatcc gtcctgctcc aggattccca
     1081 gtgctttacg aactgtatgt ctactcaggg aatatttctg cgaaagctcg ttttctgaag
     1141 gaagcttctc tcccggtcgg atagctcctg acataatatc acttctgagc tgttccatca
     1201 gtgagaaata tttcggcttt ccattatctg tcatgtcttc ttccctcctg tatttaggat
     1261 acaacttgta cgcacgtacg aacaagttgt tttttatgca taaattatac aaaatatcga
     1321 gagatttttc attagttttt tccaaaacac ctcgagggat agtgatatgt gaacagtaac
     1381 agttcatcct ttacgaaagt taccaatatc cgattgattt caacatcact tcggcccagc
     1441 tttttctata ccataacatt catggcaaat cccatgtacc gccatacgta tttctttatc
     1501 cagacgtgaa ttacaggtga tcagagtcac cattctctcc ctttcatcag gctctactcc
     1561 tgtgtcatac atggaattat ttttcaatat agataattgt ctcctgtatg caggactgga
     1621 taacttgtat ccatattcaa atgccgggct ttgggaagat gcctgttcca cagaaaaaat
     1681 tttgtacaga aactttcttt ttggtgttgt gatctcaatt tcaggacatt ttttcagaaa
     1741 ttcaggctgt tcataacggt tcagatttgc aaacatcata ttaccttcta tattatgccc
     1801 gtaaagaata ctgtgggaat ctgtaaaatt cttttttatg tcatgttcca gaaaaataca
     1861 tccaaacaga tcttcctctc ctctgaaatt atgtttcagg taatattcat catctgccgc
     1921 ctgaactaca ggataagaaa tatcggctcc cgggacagta atccaggcaa ctgtctgaga
     1981 gttgatcttt cttaaatttt cccaggaaat cccgaaggat tccctgattt catctgtaca
     2041 gtttttgttt tttgattcag aagatcttct ctgttttttc ctgcgttttt tttcactgtt
     2101 ttttgtactg ctgtcttcat cagttttttt gccatctgcc aataatccgg caccttctct
     2161 gttcttcacc cctgccattt gggaaagctc tgcatattcc tgccttgctg caagattctg
     2221 ttcataactt tttatataga agccggcaca atatataaga agcccgattg ctgctatgat
     2281 catacttact gcaaatgttc tgagtttttt catttccgcg gcataccctt tatatttctt
     2341 ttcccggaaa cagttcttct gtagatcacc acacctcctg tcagcagtcc cattccgata
     2401 agtccaagaa cagccatcat tttaaacggt ctgacatctc ctgttttaga acttcctgcc
     2461 atggaaccac cctgatagct tccgtatcca ccggaatatc cacccgaatt tgcgtaactg
     2521 ctgcctccgc ttccggaagt cgttcctcca ttatttccac cattgtaaga tgccaacggt
     2581 gctttcgtcg gtacaggagt cattttcggg caggttcccg gtacagatgg tgttggtgtg
     2641 gcttttggct gctctgtcgg tttcggtact tctgtaggtt ttggtgtctc tgtcggcttt
     2701 ggtgtttctg ttggtttcgg tgttgcagac ggtgttggtg tggcagtcgg ttctgctttt
     2761 gctttcacat atgcctcctg ctgtgcagta atttccggtg aaatatcacc tcttgctttc
     2821 gctgtgttta caattttttc aggctctgtg ctttctgttt taaataccat ttcatagcag
     2881 acttcaattt tatccatatc tgacaacgat gctcctgtct gaattacaaa tcctgtatca
     2941 tctgcctcta ttttggcatc tttcagttct ataccgtttt tcttcacaaa aatgctgtct
     3001 tttacaatgg aagccccttg ggtttccagt ttatcttcga taacaatatt ctgatctgtg
     3061 acatcctcac gcagttgtct tactgtcagt ttataatatc ctttttcacc ggacgcatac
     3121 tctttcttat ctgattcctt cacaatttcc agaatcggac tgtgtacctc tgtctctgct
     3181 tccccggttg caggtatctt ttcactgctg tctgcaactg cagtattgtg cactttctgt
     3241 cctgccaggg ctgcatcaat cactgctgcc tgatattcca cgatcatact tttctgttcc
     3301 tgacagtcca gaggattata tattacctgc tcaaaaagac cgcctttatc attatcgcag
     3361 atactatatc tactatccct gaccagtgtc ctgcctgttg acatcaggaa agtattatca
     3421 tcattgatct gtacatcagc atctgccaca tttcctttct catccatcag aatcaccgaa
     3481 tccttcagaa gacgtactcc ctgagtatcg atcacatcct gcaaagtaac attacgcgcc
     3541 acacatccgg tctgctcctg tgtcaggaca atgcggtatg taataatatc accatatttg
     3601 taaaatggtt tgtccgtcgt cttctctact ttaagaacag gcgagttcac ccagattttt
     3661 gaggagtcct ttactttctg tgcattatct gcatacgcct gtgctgtatt tacaatctcc
     3721 atcccattta cgctttcctg cgcagtacag cggaaattaa cagtcacagg tgtctgatac
     3781 ggaagatctg aaatcgtcac gatccatccg gttccctgac gtgtaacctg acagctgacc
     3841 ggtttttcca ctgtttcttt ataattttcc ggattcagct gatttcctgc atcatcagtt
     3901 cctgccaccg gattctgaat aacagccgga acaccgctta cagtaacagc atcttcagct
     3961 ccgtccagag ccagcccttc aggaagggaa agatcactga tcacaagatt tcttgcgata
     4021 gatcccttct gaagattatt aaccgtaacc tgataattca cctgttctcc tacccgaaat
     4081 tcattttccg cacgtccgtc cccggctgcc agatatggat tctgaaaact tttctcaata
     4141 gaaagaactg ctgtatttac atacacttct gcgtcatcct gtgaaacagg ggcattctgc
     4201 gcctgcacat tggcaacatt aatgctttcc attccatttg ccgcttccgt aactgtgcaa
     4261 aggaaagaaa tcataaccgg agtatttgcc ggaagatctg aaatgttcag tctccatccg
     4321 cttccctcct gaagaaattc ataattcacc ggtttctctg atgtctcatt ataaaattcc
     4381 ggattgagct ggttcaaaac atctttggtc cctgctgtca gctgcgtaat attctgtggg
     4441 attccgctta ccgatacatc ctctgccgat gaaagcgcaa gtcctgccgg cataccggta
     4501 tcccagacag ttacgttccg ggccactgta cctgcttttt tattctccac caccacattg
     4561 tactgtacct gttctccgac ctgccattca taatgatctg cagatttctc aatccagaat
     4621 tctcctgaat ttacatatac ttctgcatca tcagatctct catctgtatt aacagctttt
     4681 acagttgctg catttacgct ttcgtgtcca tttgcctctt cctgtgcgat acaatggaaa
     4741 ataatcgtta caggctgact gtatggtaca taagaacaat aaaaagaaaa tccgttctca
     4801 tctgcattca actgagaatc cacaggtctc gcttcatatg cctgtcctgt tttcttatcc
     4861 ggtacgggat agtttacctg ttgctgaact cccagtactt ccatgctctg tgtaccacct
     4921 gccagaacca gtccctgcgg cagaccaata tcagtaatag ttacatcttt tgcaattgtt
     4981 cctgccgtta cattattcac tacgatccgg taagctacct gctctcctgc ctgccattca
     5041 tatttgtctg ctgttttatc aatttcaagc tgtggactgt tcggccatac ttctgccata
     5101 tcctttctgg attcctgttc tcctgtgtca ggattgatca gattatccgc tgttgcagtc
     5161 acaatatttt cccattcctg tccattggaa tccgcagatg cctgacattt aaaacggatt
     5221 gtgatcgtct ccccatactt cagggacgga cactctgctt tccatccatt ttctccctgt
     5281 ccggtaagcg tacagttctc gcctccctga cttgtctcta cagcatactg cccttccaga
     5341 agctgcagac atgatggaag ctcgtctgta ataacaacat ttactgcttt tacatcctgt
     5401 tttgtctgag aaaccagaac ctcataatct atgatatctc ctgttttcca ttcatactga
     5461 gaagtatttt tctttacttc cagttccggt ggaatcacac cctttaccca cactgtttcc
     5521 gtatccattg tatctccgct tccgtttgta cgttcataac tcatggatgc atggtttggt
     5581 acaagaatac tgtatccatc ctctgcaagg tattttgaaa tattaatttc tgattccggt
     5641 ctctggcgta cttttaaagt aaatgtgtaa gtctgattat ctgtaaatgc ttcatcctga
     5701 aggctctctg ctttggccct gcaggtcact ttctgtcctt caacagcaac atcaaaccag
     5761 tctgtcactg tctgccctgc atcattcaca atactgactt ttgatgcatc ctctatagta
     5821 agacaatcct caagtatatc ctgtaccaca aaggatttca gtctattggg tgtcacctct
     5881 gcccggatca tatactgaaa ttcctgtccc tgacgaatgc caaaaggttt ttcttttgat
     5941 gcagcagctg cctgttccca tgtacagttt gcctctccca cacgtttctc aggtgctttt
     6001 ttcatctcaa catcgccgaa acaataggat gtaaaatcaa aatatgcata tgctttacag
     6061 tatttctgtc ctttaaagtt cggacaataa ctgttgcctg atggatccag atatttattt
     6121 cttgtaatct ctgcccatct ttcctgagaa ccggcttttg caatggcatc ttcacgactt
     6181 ttatcccatt tatccagtct gaactgatga cagaattcta ccgtaaaatt atctgtatta
     6241 taaaaaagat tcagccatcc tctcggatca tccggctcaa cggaaccaag gggtgagctt
     6301 acagaatttc catctaccgt cagataatca ttgtttttca gaacatatgc attatccaga
     6361 ctgctgtctg acggaatacg gactccctgt cccgcatcaa tatcacgtat ggttccatgg
     6421 ccactgatcg gcagtgtttc ttctgttcca tgcttcagaa actgaaactt aacctttgcg
     6481 tatcctacag aataaataaa tacaccgata ctgtttttgg aaaagccaac cattggataa
     6541 gcttcattat ctttccatgc aaacgtagct ccgcctttat tctgaacaat cgattctgca
     6601 gtgcgcagat cataacgggg ttctgcattc tctactccca caagaatgag tctgacatca
     6661 acaatatttc catttccatc ttttcctaca ttgttataac gcatccctgc gcttccggct
     6721 ttatagtccg ctcctacacg aacgcactct gtgtcacgtt cgctttttcc attgtctgaa
     6781 aaagcttccc tgtccagatt atcacaccca aaagattcat atgtggtaat tccgggctga
     6841 aacttcatgt taaagcgata accataatct accaccttgt cactgtccca tgtttctaca
     6901 gttaacggtg ccgcctgagt tacgcagaca ggcacaagcc ccagaattgc ctgcagaata
     6961 aaaagcattg caagcagcaa agctccaagg cgttctttca gtttgaaatt gtgtttcatt
     7021 ttccgtctcc tttccgaaca aaaaatataa aaatgaatgt gggatttttc cctgcacctg
     7081 gcaggattaa agaatagaaa taagttgaga ttgtatgatt ataaatattc aaggggaatt
     7141 aatatcgtga aacaagaacg tttacactta agatttttaa gattctgcgc agggtttctt
     7201 ttctgaaacc ctgcacagat tttcattgat catttctttt cttcagccat gaaagaaaat
     7261 aaagaataat tgcaagaata ataaaaaacg gaatcgcaac tccgattatc agtatcagta
     7321 aaacaattat aacagccgcc gctgcaataa caacagccct gccatgccag gtagaaagat
     7381 cgattacttt tttccatctt ttctcctgct gatgaggaag ctctgtctca ttgccataac
     7441 tgcttccgta agaagaatac tctccgtaat cttcctgtgt acttccatca tctgtatcga
     7501 tcagagtttt tgctatcaga tgcgggtctc ccagttcctg cagtacttcc tgctctgaac
     7561 gtccgccacg tacctgagac tgtatataat cttcataata cctgatatgt gctgctgctt
     7621 tgccctcctg catctgaccg gcaagctggc ttctcaggat ttccaaaaat tcttttctgt
     7681 tcatcttcta cactccattt tgccagaaat acatgtcaaa actctactgc tcgctccgtt
     7741 atcagtaacg ttcgtactct tattttacca tatataccgc aggtagcaac taatataatc
     7801 ataaactttt tatgaaattc ttataaacac atatatcgtt ttggaaataa cactgcaaat
     7861 ccactcggat tctcctgctt tcgtcatttt ccgacaattt ttgcatacat ttcaggtctg
     7921 cggtctctga aaagtcccca gttcagtcta tctgccttta atgcatccag gtcaaaagtg
     7981 cttacaagca ccccctcttc ccctccgggc agttctgcac agagagcacc tgtgttgtct
     8041 gtgataaaag aagagccgta aaaattaaga gcagatttct gcattccgtt ttccggacat
     8101 ggctctactg tttcctcacc gattctgttg gcagcgatca caggaatcag gttggaggca
     8161 gcgtgtccct gcatacatct tctccagtgt tccatgctgt cacattccaa gatgggttca
     8221 cttccgatgg cagtgggata aaagagaagc tctgcgccct gcagtgccat acatcttgcc
     8281 gtttccggga accactgatc ccagcagatt ccaactccaa tggttccaaa tctggtatca
     8341 aaaaccttaa agccggtatc tcccggtgtg aaatagaatt tttcctgata ataatggtca
     8401 tccggaatat gtgttttccg gtaaacgccg agattcttcc catctgcatc cagaaccgca
     8461 acgctgttat aagtattatt gacctctttt tcataaaagc tgaccgggat cacaatcccc
     8521 agctctgccg ctaccctgct gaaatgacgc actgcagggt tttcctctgc agtctgcgca
     8581 tattcataat actcatatct gcgctcctgg cagaaatagg gccgttcaaa aagctccgga
     8641 agaagaacaa tctcagctcc ctttgctgct gcctgacgca ccagttcctc tgcatgggca
     8701 atatttttct ccacactttt actgcatttc atctgaactg ctgccactgt tacatttctc
     8761 atcctgtctg ttcctcctgc tcctgtttac ataagtaagt tttttcataa ctttcaggta
     8821 taaccctcaa acacatgact ctcaaagttt tctgcatcag ggtcagatat tttttccggg
     8881 aatctgctgg gtaatacagt gaatatttcc accgccgaca atgatggctc tggcatcaat
     8941 gggataaatc cttctttcag gaaaacactt ctgcagaatc tccactgccc ttttgtcatt
     9001 ttcatcccca aactgtggaa ggatgattcc tccattggaa atatagaaat tcacataact
     9061 ggcagccatc cgttctcctg cttcccgttc gtcttctccc tcttcaaaca caaagccatc
     9121 cacatcttcc cgggtaaggc agaccggttt ctgaggaatc ggaagcttat gaatcttaaa
     9181 ttttctgcct tttgcatctg tttcctgttc cagcaccttc agatcagcca aagacatggc
     9241 atactgcgga tctgtctcat cctctgtcca tgcaagcaca acctctccgg gccttacaaa
     9301 agcgcacacg ttatccacat gctcattggt ttcatcctga tagattccac atggaagcca
     9361 gataatcttg tggacaccga gccagtactt caactgttcc tctatctgtt ccctgctcat
     9421 ctgaggattg cgtccctgac tcagaagaca ggcctctgta acgatcagag tcccctctcc
     9481 gtcagaatgg atggaaccgc cctccagcac aaaaggtctg gcatccagac atggacaacc
     9541 gagagtcctg cagataaagg cagccaccct gtcgtccttc tcccagttcc ggtaaagtcc
     9601 atcaaagtct cctccccacg cattaaactg ccagtcaact ccacagaccg cccctttctc
     9661 atccagaacc atggttgctc ccacatctct ggcccaggcg tcatctgtct cgcattccag
     9721 caaagtcaca ccggaaacat tcccaagctg attctttgca ttctccatct gagctttgga
     9781 aaccagcata tacacctttt cgctcactcc aatagcctct gcaactttca caaatgcttt
     9841 ctgtgcttcc cttgccccat aattccagga accgggacgt tccggccaga tcatcacaca
     9901 tccctcatga ggctcaaatt ctccgggcat acgatatttt gttctgttct tctctgtaac
     9961 ttccatgtct gtctcctttt ctttgatagc ccggcagata tcaggaaagc cggctcttaa
    10021 aatcttcgta tccgaaatgt ctgataacct cacactctcc gtcctcatgc ataaccgcaa
    10081 tatccggcag cggcataccg ttaaatgtat tattcttcac catagaataa atcgccatat
    10141 ccataaaata cagcttgtcc ccgatccgga tctctctgtc aaaggaataa tctccgatca
    10201 catctcctgc caggcaggtg caggaagata agcggtaggt atatgccttc tcccctgctt
    10261 ccccgctgtc cttaagaggc ggacgatagg gcatctccag cacatccggc atatggcagg
    10321 ctgcagaagc atccaaaatc agcgttctga tctcattttc cacaatgtcc ataacctctg
    10381 tcaccagata tccggcattc agggcaacag cctccccggg ctccagataa atatccagat
    10441 cataggtttc cttcatatgc tgaatacatt tttccaggag ctttacatca taatcctctc
    10501 tggtaatgtg atgtccgccg cccatattca accaggaaac ctcagacaga aattctccaa
    10561 acttctcctc tactgcctgc aatgttttct ccaggtcatc tgcattctgt tcgcagagcg
    10621 tatggaaatg cagtccgtcg atccatttca gacattcccc gtcaaagttc tctctggtaa
    10681 cccccagcct ggaacccggc gcacagggat catagagtgc atgatccccc tgagtggagc
    10741 attccggatt aatacggagt cccagactgg ctctggtaca cacatcttta aatttcttca
    10801 gctgtgctgt ggaattaaag ataatatggt cacagatccg atccagttcc tctatatctt
    10861 ctgtacggta agcaggggaa aaaacatgat tctctttccc catctcttca tatccaagcc
    10921 ttgcctcaaa cagaccgctg gcagtggtac ctgccagata ttttccgatc atgggataca
    10981 gagcaaagcc ggaaaacgct ttctgcgcca gaaggatctt acacccggta tcctcctgga
    11041 cttttttcaa aatctccaga ttctcccgca tcttcttctc atcgatcaca tagcagggag
    11101 tttgcagttg atcaatcttc attggctttc cagaccttta ccagttcagg atcttcgcag
    11161 actttccatg gaagtcccca tttgttcagt gcttccatat atggatccgg atcaaattct
    11221 tccacattaa atacacccgg cttcttccac tgtccggtca ctaccatcat ggaaccgatc
    11281 atagccggaa cacctgttgt ataggagatt gcctgggatt ccacctcttt atagcattcc
    11341 tgatgatcac atacattata aatataaata cttttctctt ttccgtcctt aacacctgtg
    11401 aaaatacagc caatatttgt tttacccact gttctcggac ccagagatgc aggatccggc
    11461 agaagagctt tcaaaaactg gatcggcacg atctcctgtc cattaaattc cacaggtgcg
    11521 gtggaaagca ttcctacatt ttccagacat ttcatatgtg tcagatagct ctgtccgaat
    11581 gtcataaaga aacggatcct ctgtactccc ggaatatttt ttgccagtga ttcaatctct
    11641 tcatgatgaa gaagatacat atccttcttt cctacctcag ggaaatcgta gacagattta
    11701 aattccatag gctctgtttc tacccaatgt ccgtcttccc agtaggaacc atttgcggaa
    11761 acctctcgaa gattgatctc cgggttaaag tttgtggcaa aaggatatcc atgatcaccg
    11821 ccgttacagt ccagaatatc aatggtatgg atttcatcaa aataatgctt cagggcatag
    11881 gcactaaata cactggtaac acccggatca aaaccggttc ccagaagagc agtcagtcct
    11941 gcttccttaa atttctcatc ataagcccac tgccaggaat aatcgaaata tgcagtaaag
    12001 cctttttctt tacatctctt ttcgtagatt gcacgccatg tgggatcttc tgtatcctct
    12061 gcttcataat tggcagtatc aatataatcc gcaccggctt ccagacatgc atccatgatg
    12121 gtaagatcct gatatggaag tgccacattc aggacagcat ccggcttata gactctgatc
    12181 aattctgcga cctctgctgc attatccgca tctacctttg ctgtctcaat ttttgtcttc
    12241 gttgtacttt caatcttctc tttgagtgca tcgcattttt cctttgtcct gcttgcgatc
    12301 ataatctctg taaaaacatc gctgttctga cagcatttgc gaattgccac tgaagctacc
    12361 ccaccacatc cgattaccaa taatctgctc ataaactgtt ttcctcctct tccagtaaat
    12421 cttctacata ttttggaagc ataaatgctc ctctgtgaag gtttgttgta taataccatg
    12481 tttctatatt aagattatca aacctctccg gcctgaaatc ttccagtgga tgatatttct
    12541 ttgatgcaaa tccaaaaagc cagtatcccg agggacaggt agggatatgt gcctgataaa
    12601 ccctgctcac cggaaatgac cggaaaacct ttctgtgcat ctttctgcat tccacctcat
    12661 cctcatcata aaaaggactt ccatgctgat aaaccatgat tccgtcatct ctgagagcct
    12721 tataacagct tccgtagaat tcctttgtaa aaagtccctc tgtatgtccc agcggatctg
    12781 tggaatcatt gatgatcagg tcatatctgg cctttttatt ccgcaggaac cgaaggccgt
    12841 cttcataata aatgttgact ctctcatcct tcagtccctg ggcaatatcc ggaaacatct
    12901 ccgcacatac atccacaaac attttatcgg attccaccac atcaatgctc tcaatctgtg
    12961 gataatggat cagttctctg gcaactccac cgtcaccgcc gccgatgatc agaacatttt
    13021 ttacattggg atgtactgtc attggcacat gcgtgaccat ttcatcataa ataaattcat
    13081 ctttatcaga gaatacgatc tcaccgtcca gagccacaaa tcttccaaat tcttcagact
    13141 caaacacatc gattctctga aattcacttt cccctgaaaa taactgtcgg ttaatccgga
    13201 cagaaagctt tacatttcct gtatggaact cggaatacca taattccatg atcagatacc
    13261 ccctttcagg acctgaagat gttctacctt cggatcctcc attccctgca tggaacagcc
    13321 tttgtctctt gcataaagaa tgtattctac aatttcctgt gtcaccattt ctccaggagc
    13381 aagaatcggg attcccggag gataacacat aacaaattca ccgctgatcc tgcctgccgc
    13441 ctgttccatg ggcagagatt ctttctccgc ataaaatgcc tgctgtggag acgccaccac
    13501 tgcaggtgcg atatattccc cggaaagcat acctgtgctg tccttcttat acagacgttc
    13561 aatatcagcc aatgccccta ccagtctctc aatatcctga agcctgtctc cgatggaaat
    13621 gtaagccaga atattacaga tatctccaaa ctcgatctga atatcatatt catctctgag
    13681 aagatcataa acttcaatac ctgccagccc atttcccagt gtataaatgg agagttttgt
    13741 aacatcaaaa tcaaaaacac tggttccatt gatcagatcc ataccatatg cataataacc
    13801 gccgatctca ttgatctcct ctctggcata ctgcgccatc cctgcaacct tttcaaagga
    13861 ttcctctccc ctgagtgcca gatttcttct ggagatatcc agactggaca acagaagata
    13921 agaagcgctt gtggtctgag tcaaattgat gatctggcgc actttctctg cattcatact
    13981 cttattcaaa agcagcagcg aactctgtgt cagacttccg ccggatttgt gcatggaaac
    14041 tgccgccatg tcagcacctg ccgccattcc ggacacagga aggtttctgc cgaaataaag
    14101 atgggttcca tgagcctcat ctgccagcac cttcattcct cttgcatgag ccttctttac
    14161 gatagtccgc agatccgaac agattccata ataggtaggg ttatttacaa gaactgccac
    14221 cgcatccgga ttctcatcca tagccttctc cacctgactg acttccatgc caagggaaat
    14281 gcccagctgc gcattcacct ccgggtttac ataaaccgga attgcaccgc acagtaccag
    14341 ggcattgatg gcacttttat gtacatttcg cggcagaatg atcttatccc ctgccttgca
    14401 gacagacagg atcatgctct gcactgcaga tgtggttcct cctaccataa ggaatgcatg
    14461 cgctgcgcca aaagcatctg ctgcaagctc ctccgcttct ctgatcaccg aaaccgggtg
    14521 gcagagattg tccagcggct tcatagaatt aacatccagc cccacacatt tctctcccag
    14581 caactgtgca agctccggat ttcctcttcc tcttttatgt cccggcacat caaagggaac
    14641 gactctcttc tttcggaaac gttccagtgc ttcatatatg ggcgcatgct gttgtctttc
    14701 ataatccatt tgacatgttc ctcttttcct gtcgtcatgt accggcaaat acagttctat
    14761 cattcagcaa ttgtatactg cctcaaaccg gcacaatgat tcaattattt ctatatatat
    14821 atttgctata tctgcacaaa aaaagaagca gataagttca ttcaccatct gcttctctca
    14881 tgatctatag aatttctcag gctctgtctc tttatatact gaccggattt cccgtataaa
    14941 tccgtctgta tcctgtgcct gttcccgtat tctgaaatat tcatgactgc tgtcgtcttc
    15001 aatcgctggc aaatatatgc tatgctctta ttgaccgttt cacaagatga tgtgtgctta
    15061 cgcactgatt attataaagt aatcaactta taaaatttga gcttctaact caatcaataa
    15121 tgtggtgtct cccacccggc aactgccccg cctgtccgta tggcttaaca ttcagaaact
    15181 gtctctgaat gtgagcaaat atttgcatga aaacgatagt gtcttttcat actaaaattt
    15241 agaataacat atcttctgaa ctgttgtcaa ttccattttc catattttgc actagagcgt
    15301 gtctgaaaaa ggctttctgc aagatgtgcg tcacaatttg tgggatattt tgcccggatg
    15361 agggcgccgt agcgggctac ggcaactgaa ttcgggtgaa atatcccgca aagtgggggc
    15421 gtgcagattg cgggaatgat ttttcagaca cgctctagct ttacccgctt tttatatttt
    15481 cttcatttat cagggaaaac tgtgtttatt ttttaacaat ttcttccctt gagaaaacgt
    15541 attttctttc attaccaggg attacgattc tcttctctta tcaatttgca caacttttat
    15601 ccagtttact cacatttttt gacgtttcaa caaaaatttt cttgacattt ttttctcaaa
    15661 atgatatatt gtattcatca attgaaagaa ccttcgagta ctgacggaaa gagtggagtg
    15721 caaaccacgt ggagtcggag gtttgcggga gccgaccgtc tgggcagtat ttgaaatatt
    15781 cagatactgg ccttttttta taactttcag ggcagaaatc aggaatacca ggcagaccgg
    15841 ccaatacttc tttcaattaa taattgttgc tgatcgcgga gtgaacagca acagaagttt
    15901 ttcatgttat gcggaaacga aaggagaaaa acaattatgg gattcaaatc agacattgaa
    15961 attgcacagg aatgcgagat gcttccaatt actcagatcg cagagaaagc aggtattgac
    16021 gacaaatatc tggagcagta cggaaaatac aaagcaaaaa tcgactacaa tcttctgaaa
    16081 gaaagtgata agaaggatgg aaaattaatc ctcgttacag ctatcaaccc aactccagca
    16141 ggagaaggta aaactactac tactgtaggt cttgcagatg gtatgcagag acttggcaag
    16201 agtgttatgg tagctcttcg tgagccatcc ttaggaccgg tattcggtgt aaaaggtggt
    16261 gcagcaggcg gcggatatgc acaggttgtt cctatggaag atattaacct tcacttcaca
    16321 ggtgacttcc atgccattgg cgcagctaac aacttacttg cagctatgat cgataaccat
    16381 atcttccagg gcaatgcatt aaacatcgac ccacgtaaga tcacatggag aagatgtgta
    16441 gatatgaacg accgtcagct tcgtaacgta gtagatggtc ttggcggaaa gacaaacggt
    16501 atgcctcgtg aagacggata cgacatcaca gttgcatctg aaatcatggc agttctctgt
    16561 cttgcaagcg acatcaaaga cctgaaagaa agattatcca agatcatcat cggatataca
    16621 tacggaaaag tttccgagca gaaacctgta acagcaggtg accttcacgc agaaggcgct
    16681 atgacagccc tgttaaaaga tgctctgaaa ccaaaccttg tacagactct ggaacacgtt
    16741 cctgcaatcg tacatggcgg accattcgca aacatcgctc atggatgtaa ctctgtaaca
    16801 gctacaaaga tggctatgaa gcttgctgat tatgcaatca cagaagctgg tttcggtgct
    16861 gaccttggtg ctgagaaatt ccttgatatc aaatgccgta tggctggttt aaaaccaagc
    16921 gcagttgtaa tcgtagctac agtacgtgcc ctgaaataca acggcggcgt tgctaaagct
    16981 gaccttaaca atgaaaacct ggaagctctt gaaaaaggta tcccgaacct gttaaaacac
    17041 gtttccaaca tcaaaaacgt atacaaactt ccatgtgttg ttgctatcaa cgcattccct
    17101 acagatacaa aagcagagct tgactttgta gaagctaaat gtaaagaact gggcgttaac
    17161 gttgctcttt ctgaagtatg ggcaaaaggc ggcgaaggcg gaatcaaact tgcagaagaa
    17221 gttatccgtc ttgttgaaga accaaacgac ttctcctatg catatgaact ggaaggttct
    17281 atcgaagaca aactgaacca gatcgttcag aaagtatatg gcggtaagaa agtagttctg
    17341 acagctaacg ctcagaaaca ggcgaaacag ttagaagctc ttggctttgg caactgcccg
    17401 atctgtgtag ctaagacaca gtacagctta acagatgacc agactaaact gggtgctcct
    17461 actgacttcg aagttacagt acgtaacctg aagatttccg ctggtgcagg attcatcgta
    17521 gctcttacag gcgagatcat gacaatgcca ggtcttccta aagttccggc tgctgagaga
    17581 atcgacgtag acgagacagg taagatcaca ggtctgttct aatccggttg aaatcagtcg
    17641 aataattcaa aaatataaaa atcatattta tatatgatat gtgtccagac gattttacag
    17701 gcgggaagat tttcccgcct gtttttttct ttattttttt ataagataat cttttccgga
    17761 aataccaggt tccgtcatat ggaccggatc cagaatgcga ttaagttcat cctcgtccat
    17821 aagcttttct ttcagaatca gacttcttac agattcgcct gtcttaattg ccttttttgc
    17881 aatatccgca gccttctgat atccaagatg ggggctgatt gcagtgataa tacctacact
    17941 gttttctacc agataacggc atctttcttc atttgccgta attcctacaa tacaattatc
    18001 caccaatgtc tggactgcat agccaagagt atcgatagac tggaacatgc aatagaaaat
    18061 aatcggctca aacgcattta attccagctg accagcctct gcagccatgg taatggtaac
    18121 atcattacca ataatattaa aagcaacctg attcactact tcaggaataa ccggattaac
    18181 tttacctggc ataatagaag aaccattctg ttttgccgga agattaatct ccccaaaacc
    18241 agtacgtgga ccggaggaca tcagacggag atcatttgac attttggaaa gagttaccgc
    18301 acatgctttc acagcaccgg aaacggctac aaatggatcc agattctgag tggaatcaat
    18361 caaatcaaag gcctgtataa agtccattcc tgagatttca gtaagatttg gaacaattct
    18421 tctcagataa ccttcatctg cattaattcc cgttccaata gcagtgcctc ccatattaag
    18481 agtccgcatt tcatccattg ctttatccat tctgtggata tcacgcatga ttgctaccga
    18541 atatgcctta aattcctgtc ccagacgaat cggcactgca tcctgcatct gtgtacgccc
    18601 catttttatt atgtgatcaa actctgtagc tttttcatta agagcatcat ataggcgaag
    18661 aagctgtttt ttcagattct gcaacaaacg aagagaagtc attttaccgg cagtaggaat
    18721 aacgtcattg gtagactgtc cacaattcac atcatcgtta ggatttataa ttgtataatc
    18781 gccctttttt cctcccagta tctcaatcgc gcgatttgca attacttcat tggcattcat
    18841 atttaaagat gtgccagctc ctccctgaac aggatccaca ataaattcat tatggaattt
    18901 tcctgaaaca atttcatcac atgcctggac aatcgcctgt gcttttttct tctcaagaag
    18961 ccccacctca caattggtta tcgctgctgc tttttttatg tatgcaagac tgttaataat
    19021 ttccggatgc atattcaacc ccgtaatgtg gaaattttca gccgcacgta aagattgtac
    19081 tccataatat acatcttccg gaatatcctt tacaccaata gaatcccttt ctacacgata
    19141 gtctgttttt ttcatagtta ttcgccctcc catgtatttg ccctcattat atatctctgc
    19201 tataatataa tcaaatacat atatttttat aaaatatata gtgtttaaat tatatatcgg
    19261 aggagtttat atgtttcagg gaatggaata catctatgag gtctacaagg aaaaaagctt
    19321 ttccaaagct gctgctgctc ttttcatttc gcagccttct ttaagcgcca atgtaaaacg
    19381 tgtggaaaac cgtattggct atcctatttt tgatcgaagt accaaacctt tacagttaac
    19441 tgaagtcgga aaacattata tacaggctgt tgaaaaagtc atggatattg aaaataatct
    19501 cgaaaactac ctactggatc tgggaaatct caaaacagga actcttaatg taggtggcag
    19561 taactttttt tcttcgtgga ttctgcctcc ccttattgct gatttttccc aaaaattccc
    19621 ccatgttcaa atttctcttg tagaagaaag tacagcaaag ctatcccagt ttctccaggc
    19681 cggaaagtta gatctggtga ttgataactg tattctggat aaccagattt ttgaacgtta
    19741 tatctaccag aaagaacaac ttcttcttgc agttcccaaa aattattcag taaataccag
    19801 actgcagaaa tatcagattc ctattgagga aatccggaac gggcagttcc gttcttctca
    19861 tattccttct gttccattaa acaaattcga gaacgaacca tttattattc ttcgttcaga
    19921 taatgatacc ggtaagcgtg cacttaccat ttgtcaggaa aatcactttt cgccttctgt
    19981 agtatttcgc ctggatcagc agatgactgc ctataatatt gcatgtttgg gaatgggtat
    20041 cactttcatc ggggatcttc tgctctccag agttccaaca aattcagaac ttgtttttta
    20101 taagctgccc ggtcagagca gtaaacgcac tgtgtttttt tactggaaga aaggccgcta
    20161 tatcagcaga gccatggaag aattcctgaa gctgcccttt tcctgatatg tcataatcaa
    20221 ataggctatg gtgattggtc atcatcagat gtacgtcaaa atggggttgt tgtgctaaat
    20281 aagcacaaca accccagtat gtcaggcaga tattcgatta gaacagtggc ttcatagccg
    20341 gatacagagt tctgaacttc tgatatctct cttcatattt tgcaaccagt tcaggatccg
    20401 gttctactgt atcaacaact ttggcaaatt tcttaccgat ggtttctaca tccgggtaag
    20461 caccacagcc tactgctgcc agcatagctc cacccatgga cggtccttct tcgttctcca
    20521 gaacatcaac cttcaggttc ataacgtttg caatgatctt cttccacagt gggctcttag
    20581 ctccgccacc gcagatcttg gttctctcaa tcttgattcc aaggcttctt gcaacttcca
    20641 gggaatcacg aagaccaaag gcaacacctt ccagaacagc ctgtgtcatg tctgctcttg
    20701 tgctgtccat ggacatcccg aagaatacac ctcttgcatc aggattatta tgaggtgaac
    20761 gttctcccat caaatatgga aggaagaata catgattctc tcccagcttc tgaattggag
    20821 cctgctctgc tgcgaaatcc tttgtctgaa gaatctcctc tgcccaccat ttgttacagg
    20881 aagctgcgct gagcatgcat cccatcagat gatagcttcc atctgcatga cagaaagaat
    20941 gaagtgcgtt attttcgtcc acaccaaagt ttttactgga aataaacaca gttccggatg
    21001 ttccaagaga aatattacac tgaccgtcac caactgtacc tgttcctaca gcagctgccg
    21061 cattgtcacc tgcacctgca acaactttta cattctcact gaatccaagt tctttcgcaa
    21121 tctcaggttt cagagttcct actacttccc aactctcata cagtttcgga agctgctctt
    21181 ctgtgattcc acagatctcc agcatttctt ttgaccagca gcggttcttc acatcaagaa
    21241 gaagcatacc ggaagcatca gaaacatctg tacaaaaaga accggacaga cgatatgcca
    21301 gataatcctt aggaagcata atctttacta ccttcttaaa gttctcaggc tcatttttct
    21361 gcatccagag gatcttcggt gctgtgaagc ctgcgaaagc aatatttgct gtatactgtg
    21421 aaagtttgtc ttttccgatc actgtattca gatattctgt ctcttcgcct gtacgtccgt
    21481 cattccagag gattgcagga cggattacat tatcatcttt gtcaagagtt acaaggccat
    21541 gcatctggcc accaaaacca attcctgcta cttgagttct gtcaatatcc tttgtcagtt
    21601 ctttcatgcc ttccatgctc tgtatgaacc agtcctccgg tttctgctca gaccagcccg
    21661 gatgtgggaa gaataatgga tattctctgg atacgatgtt acagattttt cctgattctt
    21721 ccataagaag aagttttaca gcggaagtac caagatcaat accgatataa tacataagtg
    21781 cgctcctttt ctatttctaa tctaatacat cccagagcaa agccccggga tgcctttaat
    21841 atagtgtcag tttatttatt ctgtattcag attcattcac atcacatgaa cattaataac
    21901 ccgttttact gatttctcat taaccccatg gattctctgt cggatatctt acacctgccg
    21961 gctggttgta tccaatcttc ttaacatcca gtccaaggaa tttcactacc tcatagaatg
    22021 cttttccgta atgtccaaac ataactgctc catgatgcgg atagttgccc tcgatcagta
    22081 cgtgacggta gaatcttccc atttctttga ttgcgaaaat accgatacca ccgaatgatc
    22141 ttgtaggtac atccagtact tcaccttctg caacataaga aaccagctcg ccctcggaat
    22201 tgcactgtaa acgatagaat gtaatgtcag atgcagcgat atcaccttca agagttcctc
    22261 ttgtgaagtc tggttcagat cctgccggct caagaagtct gtgctggatc agctgatatt
    22321 taacagctct ggaatcacac atcttgcatg caggagtatt tccacaatgg aatcccataa
    22381 atgtatcagt aagcttataa tcgtattttc ctttaatatc ttcatcatag atatactgtg
    22441 gaacagagtt gttgatatca agcagtgtaa ctgcatcatt ggaaatgcaa agtccgatgt
    22501 actcgctgag tgctccgtag atatcaacct cacaggatac cggaattcct ctggaaacca
    22561 gacggctatt tacatagcaa ggttcaaatc caaactgtga cgggaatgca ggccaacatt
    22621 tgtcagcaaa tgcaacgtat tttcttgctc ccttatgagc ctctgcccag tcaagaagtg
    22681 taagctcaaa ctgtgccatt ttcacattaa ggtcagcata atatttgcct tcgcccatct
    22741 cttttgccat atctgcacaa acttccggga tacgaggatc attttcatgc tctttgaaag
    22801 aaacaagaag atcaagctct gagttctctt caatctcaac acccagctca tagaggcctt
    22861 taataggtgc gttgcatgcg aagaagtcct gtggacgtgg tccgaaagta atgatcttaa
    22921 gattgctgac accgatgact gcacgtgcaa ccggtacgaa atcagcgatc atctttgcaa
    22981 tatcatctgc tgttccaaca ggatattccg gaatatatgc tttcagatga cgcattttta
    23041 agttgtagga gcagttaagc ataccacagt aagcatcacc tctgccgttg atcatatcac
    23101 cgtcaccttc tgctgctgct acatacatac aaggtccgtc aaatctctct gcgatcagag
    23161 tttcaggagt ttcaggtccg aagtttccaa ggaaaacaac cagcgcatta cactctgctt
    23221 tgtttacatc ttcaagagct ttctccata
//
