LOCUS       c00024_gnlPro..        16558 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|ELDFHDME_35.
ACCESSION   c00024_gnlPro..
VERSION     c00024_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-04 02:10:37
            Original ID  :: gnl|Prokka|ELDFHDME_35
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 16558
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..16558
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[950:6558]"
                     /cutoff="10000"
                     /detection_rule="(TPP_enzyme_C and not (PFL-like or
                     PFL_6_pcresol or PFL_9_tma or Gly_radical or Gly_430_pcre
                     or Gly_8-9_TMA or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and
                     minimum(2, [ALS_ss_C, AlaDh_PNT_C, Arginase, BKACE,
                     BcrAD_BadFG, Beta_elim_lyase, CPSase_L_D2, Cys_Met_Meta_PP,
                     ELFV_dehydrog, GRDB, Glu_syn_central, Glu_synthase,
                     Gly_reductase, HAAA1, HG2B1, HG2B2, HGD-D, HleuD1, HleuD2,
                     HleuS1, HleuS2, Homoserine_dh, ILVD_EDD, IlvC,
                     Lactoyl-CoA1, Lactoyl-CoA2, Lyase_aromatic, MAAL_C,
                     OKR_DC_1_5_lysine, OKR_DC_1_5_ornithine,
                     OKR_DC_1_7_arginine, OKR_DC_1_C, OTCace, PALP,
                     Proline_reductase, Sacchrp_dh_C, TPL, Thr_dehydrat_C, TnaA,
                     Urocanase]) and not (POR or POR_N or PFOR_II))"
                     /neighbourhood="10000"
                     /product="TPP_AA_metabolism"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      951..6558
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(TPP_enzyme_C and not (PFL-like or
                     PFL_6_pcresol or PFL_9_tma or Gly_radical or Gly_430_pcre
                     or Gly_8-9_TMA or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and
                     minimum(2, [ALS_ss_C, AlaDh_PNT_C, Arginase, BKACE,
                     BcrAD_BadFG, Beta_elim_lyase, CPSase_L_D2, Cys_Met_Meta_PP,
                     ELFV_dehydrog, GRDB, Glu_syn_central, Glu_synthase,
                     Gly_reductase, HAAA1, HG2B1, HG2B2, HGD-D, HleuD1, HleuD2,
                     HleuS1, HleuS2, Homoserine_dh, ILVD_EDD, IlvC,
                     Lactoyl-CoA1, Lactoyl-CoA2, Lyase_aromatic, MAAL_C,
                     OKR_DC_1_5_lysine, OKR_DC_1_5_ornithine,
                     OKR_DC_1_7_arginine, OKR_DC_1_C, OTCace, PALP,
                     Proline_reductase, Sacchrp_dh_C, TPL, Thr_dehydrat_C, TnaA,
                     Urocanase]) and not (POR or POR_N or PFOR_II))"
                     /neighbourhood="10000"
                     /product="TPP_AA_metabolism"
                     /protocluster_number="1"
     cand_cluster    1..16558
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(TPP_enzyme_C and not (PFL-like or
                     PFL_6_pcresol or PFL_9_tma or Gly_radical or Gly_430_pcre
                     or Gly_8-9_TMA or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and
                     minimum(2, [ALS_ss_C, AlaDh_PNT_C, Arginase, BKACE,
                     BcrAD_BadFG, Beta_elim_lyase, CPSase_L_D2, Cys_Met_Meta_PP,
                     ELFV_dehydrog, GRDB, Glu_syn_central, Glu_synthase,
                     Gly_reductase, HAAA1, HG2B1, HG2B2, HGD-D, HleuD1, HleuD2,
                     HleuS1, HleuS2, Homoserine_dh, ILVD_EDD, IlvC,
                     Lactoyl-CoA1, Lactoyl-CoA2, Lyase_aromatic, MAAL_C,
                     OKR_DC_1_5_lysine, OKR_DC_1_5_ornithine,
                     OKR_DC_1_7_arginine, OKR_DC_1_C, OTCace, PALP,
                     Proline_reductase, Sacchrp_dh_C, TPL, Thr_dehydrat_C, TnaA,
                     Urocanase]) and not (POR or POR_N or PFOR_II))"
                     /kind="single"
                     /product="TPP_AA_metabolism"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..16558
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="TPP_AA_metabolism"
                     /region_number="1"
                     /rules="(TPP_enzyme_C and not (PFL-like or PFL_6_pcresol or
                     PFL_9_tma or Gly_radical or Gly_430_pcre or Gly_8-9_TMA or
                     PFL_acetate1 or PFL_acetate2 or Gly_radical_scatole or
                     PFL_proline or PFL_toluene) and minimum(2, [ALS_ss_C,
                     AlaDh_PNT_C, Arginase, BKACE, BcrAD_BadFG, Beta_elim_lyase,
                     CPSase_L_D2, Cys_Met_Meta_PP, ELFV_dehydrog, GRDB,
                     Glu_syn_central, Glu_synthase, Gly_reductase, HAAA1, HG2B1,
                     HG2B2, HGD-D, HleuD1, HleuD2, HleuS1, HleuS2,
                     Homoserine_dh, ILVD_EDD, IlvC, Lactoyl-CoA1, Lactoyl-CoA2,
                     Lyase_aromatic, MAAL_C, OKR_DC_1_5_lysine,
                     OKR_DC_1_5_ornithine, OKR_DC_1_7_arginine, OKR_DC_1_C,
                     OTCace, PALP, Proline_reductase, Sacchrp_dh_C, TPL,
                     Thr_dehydrat_C, TnaA, Urocanase]) and not (POR or POR_N or
                     PFOR_II))"
                     /tool="gutsmash"
     CDS             951..2669
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: TPP_enzyme_C"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg24_1"
                     /sec_met_domain="TPP_enzyme_C (E-value: 3.4e-48, bitscore:
                     155.5, seeds: 323, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKQISGNKLLVKALKEEGVEYLFGYPGACTIDISDELYKQDDVKI
                     ILPRHEQALVHEADAYARTTGKVGVCLVTSGPGATNLVTGLATANYDSVPLVCFTGQVA
                     RHLIGNDAFQEVDIVGITRSITKYGVTVRRREDLGRIIKEAFYIARTGRPGPVLIDLPK
                     DVMAELGSAEYPKNVNIRGYKPNTDVHIGQLKRAIKLLNKAKRPLFLAGGGVVISRAHE
                     IFREVVEKTKVPVVTTVMGKGSIPTDHPLYIGNLGMHGAYAANMAVSNCDVLFSIGTRF
                     NDRITGKLHEFAPHAQIIHIDIDTASISRNIQVDIPIVADAKEAITKMNEYVQECSTDK
                     WLNLIKNWKEEHPLKMRPNDLLSPMDILKEINEQFENSIIVTDVGQHQMLVSQYAEITE
                     GKQMIMSGGLGTMGYGLPGGIGAKIGNPDRPVIVISGDGGVQMNIQELATAVLEELPVI
                     LCIFNNEYLGMVRQWQKLFYGKRYAMTNLRAGALSRRTEGMEYPQYTPDFIRLAESYRA
                     KGIRVTKKEEIAAAFEEAKKNTKAPTVIEFIIDPEEMVYPMIKPGGTLEDMIMDC"
     CDS             2687..3196
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: ALS_ss_C"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg24_2"
                     /sec_met_domain="ALS_ss_C (E-value: 3.2e-22, bitscore:
                     70.9, seeds: 685, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDKGMKKRWISLYVENQVGVLSKISGLFSGKSYNLDSLTVGTTED
                     PTVSRMTIATVSDDETFEQIKKQLNRMIEVIKVIDFTDVFVRMKEILYIKVFNCSKEDK
                     VELFQIAETFKAKVIDYGKDSLLLEFVQTATKNDAVVKLIKEEFHRIEVVRGGSVGIES
                     ISMMER"
     CDS             complement(3265..4521)
                     /locus_tag="ctg24_3"
                     /transl_table=11
                     /translation="VKSTERLIFHIDVNSAFLSWESARRVSQGLPDLREIPSCVGGNPK
                     KRTGIVVAKSIPAKKYGIQTGEPVAMALRKCPNLVIVPSDFELYDKCSRAFKAICASFA
                     PVMESFSIDEVFLDMTGTSLIYPDPVAAAHELKDKIHRELGFTVNVGISTNKLLAKMAS
                     DFQKPDRVHTLFPDEIPEKMWPLPIRNLLFLGKASEQKLLNQGIRTIGDLARERASNVQ
                     YWLGEKTGHQLWQYARGIDDSPVKAVPDEAKGFSVETTFNDDITSIEQVFPILLEQCDV
                     LATRMRRKDKKCNCISVTFRTLDFRNRSHQTKLENATDLTDEIYINATRLFKEFWKGQP
                     LRLIGVALTGLTDGTYEQMSLFEDTENKERRRKLDAAMDEIRMKFGNDKITRASIMNSN
                     TRIGRKAKAQMKNEKTEEP"
     CDS             5284..5997
                     /locus_tag="ctg24_4"
                     /transl_table=11
                     /translation="MYLSDIHTHSIASGHGTTCTISDMAKAASKKGLKLLGISDHGPGT
                     LASGTSSYFRSLPFYPRKRFGIDILYGVELNILDSAGHTDLSDELLNNLDYAIISMHRQ
                     NYRSGSVSQNTEAYINAIKHPAVKILGHCDDTHFPVDYETLARAALRENVIFEINEASL
                     APGGYRGDTRANAARILYLCQKYQLPVILSSDSHGKEHVGDFTYAEEFVHQLMFPETLI
                     LNNQLPKLKVFLQTR"
     CDS             6262..6558
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: ALS_ss_C"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg24_5"
                     /sec_met_domain="ALS_ss_C (E-value: 1.3e-21, bitscore:
                     68.9, seeds: 685, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIEVIKVIDFTDVFVRMKEILYIKVFNCSREDKAELFQIAETFQA
                     KVIDYGKDSLLLEFVQTATKNDAVVKLIKEEFHRIEVVHGGNVGIESISMMER"
     CDS             6907..7545
                     /locus_tag="ctg24_6"
                     /transl_table=11
                     /translation="MNTTTTTTTTAAAKRSSTLYMVELAMMIAIILLMSFTPLGYLRTP
                     GLSITLLTIPVAVGAIILGPKGGAVCGLAFGATSFYMAVTGSSAFAAALFNINPFGTFI
                     VCIVARVLEGWITGLIFAALYKSPAKKFSYYVASLACPLLNTFFFMGFLCLFFYNTDYI
                     QGIVSSLGVSNPVVFVAAFVGVQGLIEAGFCFVVGSIVSKALSVALKRA"
     CDS             7804..8769
                     /locus_tag="ctg24_7"
                     /transl_table=11
                     /translation="MSLLKEISITELSNLRIGHTSDHDAKTGVTVLYFPNGAKAGCDIS
                     GGGPASRETPLTSPVTADNPINAIVLSGGSAYGLAAADGVMNYLESQNIGYNTGAALVP
                     LVCQSCIYDLSYGNPKIRPTAKMGEEACRRAFAGTDTRTGNIGAGTGATVGKLYGMKQS
                     MKSGLGIAAVSVKNFQMAAIVVVNALGDIFSPQNGQKIAGLKTPDRSGFLDSVHELYRF
                     MTPHDQFTGNTTIGAVITNGAFSKAELNKIASMTRCAYARCINPVATMADGDSIYAASI
                     GDVSVDINMAGTLAAEVMAQAIQNAIHTSQIQDEEFLKYV"
     CDS             complement(9182..10366)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) MFS_1"
                     /gene_functions="transport (smcogs) SMCOG1058:Major
                     facilitator family (Score: 78.3; E-value: 1.8e-24)"
                     /gene_kind="transport"
                     /locus_tag="ctg24_8"
                     /sec_met_domain="MFS_1 (E-value: 2.1e-24, bitscore: 78.3,
                     seeds: 192, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKTNYNRTVQACFIGYVVQAIVNNFVPLLFLTFQGSYGISLQKIT
                     LLVTFNFGIQLLVDLASIGFVDRIGYRASMILAHAMAAAGLILLTVLPECLGDPFVGLL
                     IAVMIYAIGGGLLEVLVSPVVEACPTDNKEKAMSLLHSFYCWGHVGVVLLSTLFFRIFG
                     IANWKYMALVWALIPIANGILFTRVPIAPLLDEGEKGLTMGELFKKKIFWVLMLMMLCA
                     GASEQAVSQWASTLAEKSFGINKTIGDLAGPMAFAILMGSSRAFYGKFGDKINLERFMQ
                     YSAVLCMVSYLMIAFIPVPALGILGCAVCGLSVGIMWPGTFSMAAASVKRGGTALFALL
                     ALAGDVGCSSGPTYVGMISGALNDNLKLGIFAALIFPVLMIMGIKMIGSLQKYD"
     CDS             complement(10707..11471)
                     /locus_tag="ctg24_9"
                     /transl_table=11
                     /translation="MLNQFSRTELLLGKEAMNKLENSRVAVFGIGGVGGYVCEALVRSG
                     VGTFDLIDDDKVCLTNLNRQIIATRKTVGQYKTEVMRDRILDINPKADVRIHNCFYLPE
                     NAADFDFSEYDYVVDAVDTVTAKIELIMRAKEAGTPVISSMGAGNKLDASAFRVADIYK
                     TKVCPLAKVMRRELKKRGVKKLKVVYSEEQPIRPIEDMAISCRSHCICPPGATHKCTER
                     RDIPGSVAFVPSVVGLIIAGEVIKDLTAEYRR"
     CDS             complement(11465..11662)
                     /locus_tag="ctg24_10"
                     /transl_table=11
                     /translation="MQIMKRLLIKNKRKLWLWFLLLVFLFLACRAAYITGSKAEQTRNN
                     EVEERQADSRSIPNEMEILC"
     CDS             complement(11798..12484)
                     /locus_tag="ctg24_11"
                     /transl_table=11
                     /translation="MKTNEEEDSRHIFRGELALVIAVMINSLAVILMLYSGSGISAISS
                     VPYAFEKVFPVITLGTWTYIFQALLILSLMILRKKFVPAYLCSFLVGFAFSELLDVNEA
                     WINILPKTIPLRVLYFVISYLLICIGIALSNRCGLPIIPTDLFPRELSEIIKVKYSKIK
                     VSFDVICLMITACMTGLILGHINGLGIGTVMAAFTMGKVIGLIGDEMDKHFRFVNFTQH
                     CSLHVQ"
     CDS             complement(12653..14071)
                     /locus_tag="ctg24_12"
                     /transl_table=11
                     /translation="MRKTKIICTMGPSTDKGDVMEQLVREGMDVARFNFSHGPHDEQRG
                     RIQKLRELRKKYDRPVAALLDTKGPEIRLGCFKDGKVSLEEGQIFTFTNKDIEGTNECV
                     SITYKELYKDVQPGGHILVDDGLVDLEVQDIAGKDIVCKVINAGVIGDRKGVNVPGANL
                     KMPFISKKDHDDLLFGIQEGFDFVAASFTRTANDIREVRKILKENGGEEIQIIAKIENQ
                     QGVDNIDEIIEAADGIMIARGDMGVEIPPEYVPVIQQKIIQKVYTAGKPVITATQMLDS
                     MISHPRPTRAEATDVANAIFQGTSATMLSGETAAGKYPVQALQMMSRIAEHMEQNIDYN
                     TIFKKTDRNENPDITNAIAHATCLTAIDLKASAILAVTKSGSTAHMMSKHRPGCLIGAC
                     TSSERVLRQLNLSWGVYPMLIKEEYSSEILCLRAIEAAQKHKLVKVGDTIVFAGGVPLG
                     IPGRTNLIRVCTVE"
     CDS             complement(14324..14854)
                     /locus_tag="ctg24_13"
                     /transl_table=11
                     /translation="MNYNRLETSLIDVIKEEQAKLGYMKEKISLYYPLSSLNHFFGNET
                     DAAGMMEILKDFPSYIEEKFGEVAVSHRGDRFCFTVSEKASEYVHNNMKENEFIKALIE
                     LVGRHGCTIEEIKELFHSYSDKIITEPMDNEEFDVMIRFDDGSDPYYYCFKDEGCHIIY
                     HRFLPEDYADFGF"
ORIGIN
        1 ataatattta ctcaaagaat caactccttt caataatatt ctactctaat atcttgcaaa
       61 actcaacatg tgcttatatg attttataat ttatatttaa ctgttaataa ccttccaaac
      121 agctgtatta tttatttttt atatcagcaa tatagaaatc tgtcaattac attactgttc
      181 actccgttct cagtaacgta gccaaaattc attcaggaac ataaatttta cagcaattat
      241 ccaaaacccg gttgacaatt tcctctctat aaatgtataa tgtaacccaa gaaaacattt
      301 gtccacccta ttcggacaat gaatatccct atatcagcca aatgccatga cagggaggag
      361 tacacaaccc cgggaagcac agagagaaag cggtcggtgc gagcttttgt gaacgaattg
      421 tggaagtagc ccccgagcag tgaaccaaac cgcatatcca gtcagatgat tcatagaccc
      481 ggacagacat gccaagtagg cttcaacgtc agttccacgt tacaggaaca cagtatatca
      541 gtactgacaa agtgcagagc cagactctga atacaggtgg taccgcggaa acattttcgc
      601 cctgggcaaa caagcccagg gcgtttttta ctatattcag aattgtggga gctgctttac
      661 agcgttctca gcagaatcag cgcagcgcca ttctgcccct gtatcagcca atacacagct
      721 cagaaattta tttgtttggt gtgcatttgc aggagtcgtg tagatcttag tgcctagaaa
      781 tctgcgttgt tcagaaaaat ctcactgtct gagcgcagcg agtttgagat ttttctgaac
      841 gcttttagca gattttcaga cacttagatc tactaggctc cgaaaccgca caccaaacaa
      901 ataaatttct gagcgtccta tacacataca caaaggaggt ttaccaaaat atgaaacaaa
      961 tatccggcaa caaactctta gtcaaagcct taaaagaaga aggcgtagaa tacctcttcg
     1021 gctaccccgg agcctgtacc atcgacatca gtgacgaact ctataaacag gacgacgtca
     1081 aaatcatcct cccccgtcac gaacaagccc ttgtacacga agccgacgcc tacgccagaa
     1141 ccaccggcaa agtcggcgta tgtctggtaa ccagcggtcc cggagcaacc aaccttgtaa
     1201 caggacttgc aaccgccaac tatgacagcg tacctcttgt atgcttcacc ggccaggtag
     1261 cccgccacct catcggcaac gatgcatttc aggaagtaga catcgtagga atcaccagaa
     1321 gcatcaccaa atacggcgtt actgtccgca gacgtgaaga cttgggacgt atcatcaagg
     1381 aagccttcta cattgcccgc accggccgtc cgggacctgt cctcatcgac cttccaaagg
     1441 acgtcatggc agaacttggc agcgcagaat atcctaaaaa tgtcaacatc cgcggttaca
     1501 aaccaaacac agatgtccac atcggccagc tcaaacgtgc catcaaactt ttaaataaag
     1561 caaaacgtcc cttattcctg gcaggcggcg gtgtagtaat ctcccgcgcc catgaaattt
     1621 tccgggaagt agtggaaaag acaaaagtac cggttgtcac aaccgtaatg ggaaaaggct
     1681 ctatccccac agaccatccg ctctatatcg gaaaccttgg catgcatggt gcctatgcag
     1741 caaatatggc agtcagcaac tgcgatgtgc tgttctccat cggaaccaga ttcaatgaca
     1801 gaatcaccgg aaaacttcat gaatttgcac cacatgccca gattatccac attgatattg
     1861 atacagcatc catttcccga aacattcagg tggatatccc cattgttgct gatgcaaaag
     1921 aggctatcac caaaatgaac gaatacgtcc aggaatgttc aacggacaag tggcttaacc
     1981 tgatcaaaaa ctggaaagaa gagcatccgc ttaaaatgcg tccaaatgat cttttaagtc
     2041 cgatggatat cctgaaagag atcaacgaac agtttgagaa cagtattatc gtaacagatg
     2101 taggacagca tcagatgctt gtctcccagt atgcggaaat cacagagggc aaacagatga
     2161 tcatgtccgg tggtctggga acaatgggct atggtcttcc aggcggcatc ggagccaaaa
     2221 tcggaaatcc cgacagacct gtcatcgtta tctccggtga cggcggtgtg cagatgaaca
     2281 ttcaggagct tgcaactgca gttctggaag aacttcctgt tatcctgtgc atctttaaca
     2341 atgaatacct tggaatggta cgccagtggc agaagctttt ctacggcaaa cgctatgcta
     2401 tgaccaatct gcgcgcagga gcactttccc gccgcactga aggcatggaa tatccacagt
     2461 acacaccgga tttcatcaga cttgcagaga gctacagggc aaaaggaatc cgtgtcacaa
     2521 agaaagagga aattgcagca gccttcgagg aagcaaaaaa gaacacaaag gcacctacag
     2581 taattgaatt catcattgac cctgaggaaa tggtttatcc tatgatcaaa ccaggcggaa
     2641 ctctggaaga tatgattatg gactgttgat caggaggaaa attattatgg ataaaggaat
     2701 gaaaaaaaga tggatttctc tctatgttga gaaccaggta ggtgttctgt ccaaaatctc
     2761 cggacttttc tccggaaaaa gctacaatct ggacagtctt actgtaggaa ctaccgagga
     2821 ccccacagta tctcgaatga ctatcgcaac agtcagtgat gatgaaactt ttgagcagat
     2881 caaaaaacag ttgaaccgta tgatcgaggt tattaaggtt attgatttca cagacgtatt
     2941 tgtccgcatg aaagagattc tgtatattaa ggtttttaac tgttccaaag aagataaggt
     3001 tgaactgttt cagattgccg aaaccttcaa ggcaaaggtc attgactatg gcaaagacag
     3061 cctgctcctg gaatttgtcc agacagcaac caagaatgac gcagtagtga aactgatcaa
     3121 ggaagaattt cacagaattg aagtggtacg tggaggaagt gtaggaatcg aatctatcag
     3181 tatgatggaa cgataaaact ttttctgaaa tttttataaa gggaggattg tcgcattatt
     3241 cttaatgctc agtcctccct ttacttacgg ttcttctgtc ttttcgtttt tcatctgtgc
     3301 tttcgctttt cgcccaatcc gtgtattgct gttcataata ctggcacggg tgatcttatc
     3361 atttccaaat ttcatccgga tctcatccat agctgcatcc agctttctgc ggcgttcttt
     3421 attttccgta tcttcaaaca gagacatctg ttcataagtg ccatctgtaa ggcctgtcag
     3481 tgccacacca atcagacgta gcggctgtcc tttccagaat tctttaaaaa gtcttgtagc
     3541 atttatataa atttcatctg taagatctgt agcattttcc agctttgtct ggtgtgaacg
     3601 gtttctgaaa tccaaagtac gaaaagtcac ggaaatacag ttgcatttct tatcttttct
     3661 gcgcattctg gttgccagaa catcacactg ctccaaaagt atgggaaaca cctgctctat
     3721 ggaagtaata tcatcgttaa aagtagtttc cacactgaaa ccttttgcct catcaggcac
     3781 tgcttttaca ggggaatcat caatacctct ggcatattgc catagctgat gtcccgtttt
     3841 ttccccaagc cagtactgca cattggatgc tctttctctt gccagatcac cgatggtacg
     3901 gatcccctga ttcagaagct tctgctcgga agcttttccc agaaacagca gattacggat
     3961 aggaagaggc cacattttct ctggaatttc atccgggaac aaagtgtgta ctctgtccgg
     4021 cttctgaaaa tctgatgcca tctttgccaa aagcttattg gtagaaattc ccacatttac
     4081 tgtgaatccc agctctctgt gaatcttgtc tttcagctca tgagcagcag ctacagggtc
     4141 aggatagatc agagaagtac ctgtcatatc cagaaatacc tcatcaatgg aaaaagattc
     4201 catcacaggt gcaaaggaag cacagattgc tttaaatgcc cgggaacatt tatcgtataa
     4261 ttcaaaatca ctgggaacga tcaccaaatt gggacatttc cgaagagcca tagctactgg
     4321 ctcgccggtc tggatcccgt atttttttgc agggatagat ttggcaacca cgatacctgt
     4381 ccgtttcttt ggatttcctc ctacacagga aggaatttct ctgagatccg gcaacccctg
     4441 gctcaccctt ctggctgatt cccaggaaag aaatgcactg tttacatcaa tatgaaaaat
     4501 taaccgttcc gtacttttca ctgttcttcc tccaatatat gaattgcgct cttcatatct
     4561 gatgatttca ttttaccctg atctgctctc cagggtaaga acctcgtttg tccaaaaaag
     4621 tgtctttatt tgcatcatct tgtctgagct gttactgtat ttatatttgt ttgatttcac
     4681 tctgctatca gagttttgaa caacaacgcc gcacttgcca tacggcagtg cggcgtctgt
     4741 atttcgctac cggtcacatt gttcccggta acttttttta cttaattctg aggattcatt
     4801 tcctctcgat atatacttat cgattagtca taaaggttag gagcaatttc ttcgctgtcc
     4861 atatttgtgg aatcatacca gtatccagtt cagcctccag ccattcataa gagaattccg
     4921 ggaatgtctg atgtttgaaa tttttccatg ttactccttt ctcatgaagt aactgtctac
     4981 acataagcaa acagtgccat cgctgtcatt gatcagcaat aagcccccat gttttcatat
     5041 agttccatta taccttctca ttttcccgaa gtcaacataa tttaacatgt atcagccgtt
     5101 tatttgtgtt gctttttatt tgatttttgt tgtatttcag ttgtttttat tttgtttcct
     5161 cattgacatt taaatcctca tctgtcatac ttgaatataa cgaatgtacc atcaaacagc
     5221 agctttgcat cttccgtaag gctcttatca tatatagaaa ccgctctgga aaggagacaa
     5281 acaatgtatc tttctgacat ccacacacat tctatcgcca gcggtcacgg aaccacctgt
     5341 accatctctg acatggcaaa agcagccagc aaaaaaggac tgaaactcct tgggatttct
     5401 gaccacggcc cgggaactct ggcttccgga acttcttctt atttcagaag ccttcctttt
     5461 tatcccagaa aaagattcgg catagatatt ctttacggag ttgaactaaa catcctggac
     5521 agtgcaggac atacagatct gtcagatgaa ctgctgaaca acctggatta cgctatcatc
     5581 agtatgcatc ggcagaacta ccgttcaggc tctgtatctc agaatacaga agcttacatc
     5641 aatgcaataa aacatcctgc tgtaaaaata ctcggccact gcgacgatac acatttccct
     5701 gtagattatg aaacgctggc aagagcagct ttacgggaaa atgttatttt tgaaataaac
     5761 gaagcttccc tcgcacccgg aggatatcgg ggagacacaa gagccaatgc agccagaatc
     5821 ctgtatctct gtcagaaata tcagcttcct gttattttgt ccagcgacag ccacggaaaa
     5881 gaacatgttg gagatttcac ctatgccgaa gaattcgttc accagctcat gtttccggaa
     5941 actcttatcc ttaacaacca gcttcccaaa ttaaaagttt tccttcagac acgttaaaag
     6001 aatgttcctc aaagggacat tcttttattt tatgcattgt tttttgcatt gtgttatttt
     6061 gtttattttc tataatttct tgtcaaaaaa gacgacattt tagtacattt taattaacaa
     6121 aactcactta accatttaca tatctcgtga tagatcagtc ttactgtagg aaccaccgag
     6181 gatcctacag tatcccgaat gactatcgca acagtcagcg atgatgaaac ctttgaacag
     6241 atcaaaaaat agttaaaccg catgatcgag gttatcaagg taatcgactt cacagatgta
     6301 tttgtcagaa tgaaagaaat tctctacatc aaggttttca actgctccag ggaagataaa
     6361 gcagaactgt ttcagattgc agaaaccttc caggcaaaag tcattgacta cggcaaagac
     6421 agcctgcttc tggaatttgt ccagacagcc accaagaatg atgcagttgt caaactgatc
     6481 aaggaagaat tccacagaat tgaagtggta catggtggaa acgtaggaat tgaatccatc
     6541 agcatgatgg aacgctaaat ctcataatca atatttttta caggatatag aaacacctct
     6601 atatcctgta tttattttca aacatactat aaaatattgc agtttttaat caaatgtgtt
     6661 atggtttacg ggagcgttat tcgaaagaaa atgcatctgt tttccacatc tgacagtctg
     6721 gtggataaag tcatccactt cacagtctgg ttaaattcgt gaggcgacct gtaaggcgtc
     6781 tacacaccgg aaatttttct tttgttctga tgcatatttt tcataacgcc tgatccccat
     6841 actctaaact gtctgaaaag caggggacgc attgcgccgt tttatcagac caaaaggaga
     6901 attcatatga acacaacaac aaccactaca acaacggctg cagcaaaaag aagcagcact
     6961 ctttacatgg tagagttggc tatgatgatc gccattattc tgctcatgtc ctttaccccg
     7021 ctgggctacc ttcgtactcc cggcttatcc atcactcttc tcaccatccc ggtagctgta
     7081 ggagctatca tcctcggacc gaaaggtggt gctgtatgcg gacttgcttt cggtgcaacc
     7141 agcttctata tggctgtcac aggaagttca gctttcgctg ccgcactttt taacattaat
     7201 ccatttggca cttttattgt atgtatcgtg gcacgtgtgc tggaaggatg gatcacagga
     7261 cttattttcg cagcattata taaatcaccg gcgaagaaat tttcctatta cgttgcttca
     7321 ctggcatgcc cgttactgaa tactttcttc ttcatgggct ttttatgtct cttcttctac
     7381 aacacagatt acattcaggg tattgtttcc agtcttggag taagcaatcc tgttgtcttc
     7441 gttgctgctt ttgtgggcgt tcagggactg atcgaagcgg gcttctgctt tgtagtggga
     7501 agtatcgttt ccaaggcact ttctgtggca ctgaaacgtg cataatcttt aaaagaacag
     7561 ccttttccaa aaaacctgac tacattgtca ccgtagtcag gtttttttat ctggcacatt
     7621 taaaacagga atcctacctg attcaattaa tatctatagc aatctcacaa aataatgcaa
     7681 tcaagacagt tcagcagagt gcgaaagaca aggaaaatat ctgacgcagt acttcacatt
     7741 ctgataggct ggattgctct cagtatttca tagaattgct atcacataat aaaggagatt
     7801 tttatgtcat tattaaaaga gatttctatt acagagcttt caaatttacg catcggtcat
     7861 acttctgacc atgatgcgaa gaccggtgta actgttcttt attttccaaa tggagcaaaa
     7921 gcaggctgcg atataagcgg aggcggccct gcttccagag aaactcctct cacctctcct
     7981 gtcactgccg acaatcccat caatgctatt gtcttgtccg gaggttctgc ctatggactg
     8041 gctgctgctg acggtgtaat gaactatctt gaatcacaaa atatcggtta taacaccggt
     8101 gcagccctgg ttcctcttgt atgccagtcc tgtatctatg acctctctta cggaaatcct
     8161 aaaatacgtc caactgcaaa aatgggcgaa gaagcctgcc gtcgggcatt tgcaggaaca
     8221 gataccagaa ccggaaatat cggtgcaggt accggtgcaa ctgtgggaaa actttacggt
     8281 atgaaacagt ccatgaagtc aggtcttggt attgccgctg tatctgtgaa aaatttccag
     8341 atggctgcaa ttgtcgttgt caatgcactg ggagatatct ttagtccaca aaatggtcag
     8401 aaaattgcag ggctgaaaac gcctgacaga agcgggtttc tggacagtgt ccacgaatta
     8461 taccgcttta tgacacctca tgaccagttt accggcaata ccaccatcgg agctgtgatc
     8521 accaatgggg cattttcaaa ggctgaactg aataaaattg cctctatgac ccgctgtgcc
     8581 tatgccagat gcatcaatcc tgtagcaact atggctgacg gcgattccat ctatgctgcc
     8641 agcattggcg atgtttctgt agatatcaat atggcaggaa ctctcgccgc agaagtcatg
     8701 gctcaggcta tccaaaatgc catccatact tcccagatcc aggatgaaga atttctgaaa
     8761 tatgtataac agtccgctat aaaagcgcag agaaaaagta tcatctctgc gcttttattc
     8821 ttcctgtctg tcttcatttt tcatctgtgc tctggttttt ctccaagcca gagctgtaca
     8881 tttgcttccc gttcccttgc cagatcacca atagtacgga ttccctgatt cagaagcttc
     8941 tgctcggagg cttttcccag aaataacatg ttacggacag gaagtggcca cattttctcc
     9001 ggtatttcgt ccgggaacag cgtgtgtact ctgtccgttt ctttggattt cctcccacac
     9061 aggagggaat atccctgaga tccggcagcc cctggcttac ccttctggct gactcccagg
     9121 aaagaaatgc gctgtttaca tcaatatgaa aaattaatcg ttccatactt tttaatatat
     9181 ctcaatcata tttttgcaga cttccaatca tcttaatccc cattatcatc aacacaggga
     9241 aaatcaatgc cgcaaagatt ccaagtttca gattatcatt cagtgctcct gaaatcatcc
     9301 ccacataggt tggtccggat gagcatccca catctccagc aagggcaagg agggcaaaca
     9361 gggctgttcc gccacgcttt actgaggcag ccgccatgct gaaggttcct ggccacataa
     9421 tacctacaga cagaccgcaa accgcacatc caaggattcc caacgcaggt accgggataa
     9481 atgcgatcat cagataggaa accatgcaca gaactgcact gtattgcata aagcgttcca
     9541 gattgatttt atctccaaat ttcccataaa atgcccttga gcttcccata agaattgcaa
     9601 acgccatggg acctgccaga tctccgatag ttttattgat tccaaagctt ttctcagcca
     9661 gagtagaagc ccactggctt accgcctgct cactggctcc tgcacagagc atcattaaca
     9721 tcagaaccca gaagattttt ttcttaaaaa gctctcccat agtcagcccc ttttcaccct
     9781 catccagcag cggagcaatg ggaactctgg taaaaaggat tccatttgca atgggaatca
     9841 aagcccacac cagcgccata tatttccagt ttgcaatccc gaaaatacga aagaataatg
     9901 tagaaagaag taccactccc acatgtcccc agcagtaaaa ggaatgaagg agactcattg
     9961 ctttttcctt attatctgta gggcaggctt ccaccacagg acttaccagc acctctagca
    10021 atccgcctcc gatggcatag atcataactg caatgagaag tcccacaaac ggatctccca
    10081 ggcactccgg caatactgtg agcaaaatca gacctgcagc cgccattgca tgtgccagga
    10141 tcatagatgc acgataacct attctgtcca caaatccaat cgatgccaga tctaccagca
    10201 actggatccc gaaattaaat gtaaccagaa gtgtgatctt ctgcagcgaa atcccataac
    10261 tgccctgaaa tgtcagaaac agcagaggaa cgaaattgtt cacaatggcc tgcactacat
    10321 atccgataaa acaggcctgc actgttctgt tgtaatttgt tttcattcga tatgatatcc
    10381 tccaatctga aatttattag ttactgagaa cggagtaagc agtaacaatt tattacgctg
    10441 atatcgttca ggcattctca ttcaccaaat tctgcacctt cacagttcta tcaatcaata
    10501 atgacagtgt atcacagatt ctttcttttt tctttcatta tattttgaaa atcctataaa
    10561 tttttatgtt attttgactt tttctcatat aacaattcta tacactctaa caggtaatcc
    10621 atcaatccaa ttcaaaatat ttcccgcaaa aaaagatgtg taccatacca tttctgacac
    10681 catacacatc tcaaaataaa cacttcttat cttctgtact ccgcagtcag gtctttaata
    10741 acctctcctg caataatcag cccgacgaca gacggcacaa aggccacact ccccggaata
    10801 tctctgcgct ccgtacactt atgcgtagca cctggaggac aaatacaatg cgacctgcag
    10861 ctgatcgcca tatcttcaat tggtctgatc ggctgttcct ctgaataaac aaccttcagt
    10921 ttcttcacac cacgcttctt cagctctcta cgcataacct tcgccagcgg acacaccttc
    10981 gtcttataga tatccgccac ccgaaacgca ctggcatcca gcttatttcc ggcacccata
    11041 ctgctgataa caggagtccc tgcctccttt gcacgcatga tcagttcaat cttcgcagtc
    11101 actgtgtcca cagcatctac cacataatca tactcactaa aatcgaaatc agcagcattc
    11161 tccggaagat aaaaacagtt atggattctc acatctgctt tcggattaat gtccaggatc
    11221 ctgtcccgca tcacctctgt tttatattga ccaacagttt tcctggtggc aataatctgt
    11281 ctgttaagat tcgtcaggca tactttgtca tcatcgatca gatcaaaggt ccccacaccg
    11341 cttctgacca atgcttcaca tacatatcct ccaacccctc cgattccaaa cactgccacg
    11401 cgggagttct ccagtttatt cattgcttct tttcccagaa gaagctctgt tcttgaaaat
    11461 tgattcaaca taatatctcc atttcattcg gtattgaccg actatctgcc tgcctttctt
    11521 ctacttcatt atttctggtc tgttctgctt tgctgcctgt aatgtaagca gctctgcatg
    11581 ccagaaacaa aaaaacaagg agcagaaacc aaagccagag ctttcttttg ttttttatga
    11641 gcaaccgttt cataatctgc atcactattc cttaatatat tattttcaga taccagagtt
    11701 gcaacatact tccatcacag atttcttatg atatctttac ttctataatg cgtcaagtat
    11761 atcatagaaa gaaaaatcct gcaatgaaga aactctgtta ctgtacatga agtgaacagt
    11821 gctgagtgaa attcacaaac cggaagtgct tatccatctc atcaccaatc aatccaatta
    11881 cttttcccat ggtaaatgcc gccatcactg ttccgattcc cagtccgttg atatgcccca
    11941 ggatcagccc tgtcatacag gcagtaatca tcagacagat cacatcaaaa gaaaccttga
    12001 tcttagaata tttcaccttt ataatctctg acagttcacg aggaaacaga tctgtaggaa
    12061 taatcggcag accgcatctg ttagaaagtg cgatccctat acagatcagc agataactga
    12121 tcacaaaata taacactctg agtggaattg tctttggcag gatattgatc catgcctcat
    12181 taacatccaa aagctcactg aatgcaaatc caaccagaaa actgcacaga taagcaggta
    12241 caaatttttt tctcagtatc atcagactta agatcagaag tgcctgaaaa atataagtcc
    12301 atgttcccag tgtaattacc ggaaatactt tttcaaatgc ataaggaaca ctggatatgg
    12361 cagatattcc tgaaccagaa tacagcatca gaataacagc aagactgttg atcatgactg
    12421 ctatcaccaa tgccagctct cctctgaaaa tatgtctcga atcttcttcc tcatttgttt
    12481 tcataacaat tctctcctct aacacaagca agggactgct gtcagaaaat attttctgtc
    12541 atacttttct gacggcagac ccctgtgtct tttacatctt atattttctg aaaatactat
    12601 tttttatcga atcaggcaag tttcccactt caactactga tattttcctg acttactcaa
    12661 ccgtgcagac gcggatcagg tttgttcttc ccggaattcc aagcggtaca ccaccggcaa
    12721 atacaatagt gtcaccaact tttacaagtt tatgcttctg tgctgcctcg attgctctca
    12781 ggcaaaggat ctcagaactg tattcttctt tgatcagcat cgggtaaaca ccccaggata
    12841 gattcagctg gcgaagaact ctctcagagc ttgtacatgc accgatcaga catcctggtc
    12901 tgtgtttgga catcatatga gctgtacttc cggattttgt cactgcaagg attgcactgg
    12961 ccttcaagtc gattgcggtc agacaggttg catgtgcgat tgcatttgtg atatccggat
    13021 tctcatttct gtctgttttc ttaaagattg tattgtaatc aatattctgc tccatatgtt
    13081 ctgcaatacg gctcatcatc tgaagtgcct gtaccggata tttaccagct gcggtttctc
    13141 ctgaaagcat agttgcactt gttccctgga aaatcgcatt ggcaacgtct gtagcctctg
    13201 cacgggttgg tctcggatga gagatcatgg agtcaagcat ctgtgttgct gtaataaccg
    13261 gttttcctgc tgtgtaaact ttctggatga ttttctgctg gataacaggt acatattccg
    13321 gcgggatctc aacacccatg tcacctctgg cgatcatgat gccatctgct gcttcaataa
    13381 tctcgtcgat attgtcaacg ccctgctggt tctcaatctt tgcaatgatc tgaatctctt
    13441 caccaccgtt ttctttcagg atttttctta cttcgcggat atcgtttgca gtacgtgtaa
    13501 aagatgctgc aacgaaatca aatccttcct ggataccgaa gagaagatca tcatggtctt
    13561 ttttactgat gaatggcatc ttcaggtttg cacccggaac attgacaccc ttcctgtcgc
    13621 caatcacacc tgcattaata accttgcaga caatgtcctt tcctgcgatg tcctgaacct
    13681 ccaggtctac aagtccatca tcaaccagaa tatgtccgcc cggctgcaca tccttataaa
    13741 gctctttata agtaatgctt acgcactcat tagttccttc aatatcttta tttgtaaatg
    13801 taaatatctg tccttcttcc agagaaacct tgccatcctt gaagcatcca agtctgatct
    13861 ccggtccctt tgtatcaaga agtgctgcaa caggtctgtc atatttcttg cgaagttctc
    13921 tcagtttctg gatacggcct ctctgctcat cgtgaggtcc atgtgagaag ttgaaacgtg
    13981 ctacgtccat tccctctctc acaagctgct ccataacatc gcccttatca gtagacggtc
    14041 ccattgtaca gataattttg gtttttctca tttaatcttt ccctccaaac tgtcaactca
    14101 attttatcta ttttattcct gtaaaataat gtaataaaat gttacctgtt tctataaatg
    14161 aaaacattaa atcaaataaa aattaccatt attgagacta tctgtcaata tagaatttcg
    14221 acttattttt gttgatattt gacaaaaaaa taacatactt ttgttgcaaa tatcacatat
    14281 atttttactg atccgacagt tggaaaattt tcactcattc ttatcagaat ccaaaatctg
    14341 catagtcttc cggcagaaat ctgtggtaaa tgatatggca tccttcatct ttaaaacaat
    14401 aataataagg atctgatccg tcatcaaagc ggatcatcac atcaaactcc tcgttatcca
    14461 ttggttcagt aatgatttta tctgaataag aatggaacag ttctttaatt tcctctatcg
    14521 tacatccatg tctgccaacc agttcgatca atgccttgat aaattcattc tctttcatat
    14581 tattatgtac atattcggaa gctttttccg aaacagtgaa gcagaaacga tctcctctgt
    14641 gtgatactgc tacttcacca aatttctctt ctatataaga aggaaaatct tttaaaatct
    14701 ccatcatgcc tgcagcatcc gtctcattgc caaagaaatg attcagggaa ctgagcggat
    14761 aataaaggct gatcttctcc ttcatatatc caagcttcgc ctgttcctct ttgatcacat
    14821 cgatcagact ggtttctaat ctgttatagt tcatttattt tccctcctga aaatctatcc
    14881 ttttgctttt tctggttaat attttatcag acattgcccg aaaatcaatg catttctttt
    14941 tcaattgtac gcccgccaaa acaatttcaa tgttttcttt ttcatacaaa aataaagagc
    15001 ttgcgaaact gtcctttttt tctccctctg acaaataact ctgactggat aaaacaaaac
    15061 agataaaacc aaccacttcg ttgctttttt aaccaaataa ctgcttgatt cggttaaaaa
    15121 aacagcgttc cgaatattat ttatatccga aacgctgtca ttattccaat tatttcatta
    15181 tgtatttaat cccagttctt acgtccgtaa cgaagtgtca catcatatat ttccttctgg
    15241 agtttctttg taagatctct cttcttgatt ctccacttcc agttcgtacc aactgtagat
    15301 ggtttattca ttcggaatct gttgtccagt cccatatagt cctgcattgg gataacgcag
    15361 acacgcgcag cactgcgcat gatcagactg atgaaacatt tatacagttc ttcttccggt
    15421 gttgcatgat cacacagata atctctcgcc agttttctct cagctgctgt gatgctcttc
    15481 caccatccca cgatagtttc attatcatgg gttcctgtat atgccacgca gttctccgga
    15541 taattatgtg gcagataatc actggcacat ccggaatctc tggagtcaaa cgcaaattcc
    15601 agaaccttca ttcccgggaa gccgctctca tataccagat gacgtacaga atctgtcata
    15661 tatcctaagt cctctgcgat aacctgcttc catccaagcg cctgttcgat cttacggaac
    15721 agatcaattc cgggaccttt ttcccagtgt ccgcctcttg catctttatc tccgtatgga
    15781 atagagaaat attcatcaaa tccacggaaa tgatcgattc gcacaacatc atacagtctg
    15841 aagcagtaac tcattctgga aatccaccac tgatatcctg tatttctgtg ataatcccag
    15901 cgatacagcg gatttcccca taactgaccg gttgcagaaa atccatccgg agggcatcct
    15961 gctactgcca gcggtacatt atcctgatcc agctggaaca gctccggatg cgcccatgca
    16021 tcagcactgt ccattgcaac ataaatcgga atatctccaa tgatctggat tccttttgaa
    16081 tttgcatagg atttcagttt catccactgc tcatagaact taaactgcat atactgctgg
    16141 aattcaatat caaaatagag ttcttcacga taataatcca tggcattgtt ccagcggagt
    16201 ctgatatcct cagcccattt ggtccattct acaccttcga aacggtcttt tactgccata
    16261 aacagagcat aatctgacag ccaccagctg ttctctgcta cgaatttctg atagtcagga
    16321 ttcttgctga tatcactgtt ctcgtatgct tttctcagaa gaggataacg gcctttgtag
    16381 attttttcat aatctacctc atcaggcttc tttccccaat taactttctc gcagtctttc
    16441 ttatcaagaa ctccttcttc cacaagtgta tccagatcaa taaaatatgg attacctgca
    16501 aatgtagaga aagactgata tggagaatct ccatagctgg tcggtcccaa tggcagaa
//
