LOCUS       c00149_gnlPro..        14501 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|KFPIBDKP_215.
ACCESSION   c00149_gnlPro..
VERSION     c00149_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-06 05:40:14
            Original ID  :: gnl|Prokka|KFPIBDKP_215
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 14501
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..14501
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[8689:14095]"
                     /cutoff="10000"
                     /detection_rule="(minimum(4, [AcetylCoA_hyd_C,
                     AcetylCoA_hydro, B12-binding, Biotin_lipoyl, Glyoxalase_4,
                     HMGL-like, MM_CoA_mutase, MeaB, OAD_beta, OAD_gamma,
                     PYC_OADA]) and minimum(1, [CT_Btheta, CT_Propionyl_CoA1,
                     CT_Propionyl_CoA2, CT_Propionyl_CoA3, CT_Vparvula]) and not
                     Cytidylate_kin)"
                     /neighbourhood="10000"
                     /product="succinate2propionate"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      8690..14095
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(minimum(4, [AcetylCoA_hyd_C,
                     AcetylCoA_hydro, B12-binding, Biotin_lipoyl, Glyoxalase_4,
                     HMGL-like, MM_CoA_mutase, MeaB, OAD_beta, OAD_gamma,
                     PYC_OADA]) and minimum(1, [CT_Btheta, CT_Propionyl_CoA1,
                     CT_Propionyl_CoA2, CT_Propionyl_CoA3, CT_Vparvula]) and not
                     Cytidylate_kin)"
                     /neighbourhood="10000"
                     /product="succinate2propionate"
                     /protocluster_number="1"
     cand_cluster    1..14501
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(minimum(4, [AcetylCoA_hyd_C,
                     AcetylCoA_hydro, B12-binding, Biotin_lipoyl, Glyoxalase_4,
                     HMGL-like, MM_CoA_mutase, MeaB, OAD_beta, OAD_gamma,
                     PYC_OADA]) and minimum(1, [CT_Btheta, CT_Propionyl_CoA1,
                     CT_Propionyl_CoA2, CT_Propionyl_CoA3, CT_Vparvula]) and not
                     Cytidylate_kin)"
                     /kind="single"
                     /product="succinate2propionate"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..14501
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="succinate2propionate"
                     /region_number="1"
                     /rules="(minimum(4, [AcetylCoA_hyd_C, AcetylCoA_hydro,
                     B12-binding, Biotin_lipoyl, Glyoxalase_4, HMGL-like,
                     MM_CoA_mutase, MeaB, OAD_beta, OAD_gamma, PYC_OADA]) and
                     minimum(1, [CT_Btheta, CT_Propionyl_CoA1,
                     CT_Propionyl_CoA2, CT_Propionyl_CoA3, CT_Vparvula]) and not
                     Cytidylate_kin)"
                     /tool="gutsmash"
     CDS             complement(117..434)
                     /locus_tag="ctg149_1"
                     /transl_table=11
                     /translation="MRTIKVVKNTGDDLLFSIGDIGFKYDDINETQIIKYQLEIDLTEQ
                     QPIDIRFWLQEIDPDFKFLLSAPEELTEYIKKYEENNNPNDECLFHDFRTKQKIHKNCR
                     T"
     CDS             complement(421..2037)
                     /locus_tag="ctg149_2"
                     /transl_table=11
                     /translation="MKKKISADDCKKMFNDRFDSLTMKELGIELKHFSMGTAPETPSFL
                     VNQEELKQKIIERFSVFFDKNKAQGLEIIFLKSNYGNGKSHFIRMIYSFFEEYENIIAR
                     KVSLKQEKTDLKRKVLESVSQRMLKDCADLFVGIAEKDALSNNKASIIFALQEKYSIGS
                     ALALILYEAARGKDVVSQIQAVSILKGNYLPEHLKKFNFRKSDLDGQFYYDVIEMVAEY
                     LKWINNYLIIVFDEYEHVFSWKNKTDRKNLFEDIKLFTDNIETFGNMFFVFAESISADK
                     KSESSDDPAFKSRKANLTYQIADISSREEVYSLFEMILKRYEKYYEISFGENKKAMFYA
                     ICSAPEIKEKTNYRAYTQVIMQVLEQYRKKMSDKKEEKERRVTRLTSNSIKKHMAWKNA
                     TSISRKTMLCEMSEKVMEISKENIISRSKKRGEYVTNKDNIMKRYHIVATDNPSKKDLE
                     KRLRLLEENLKEEKGYLIYPALSIGQIGKLTEEKEKIKIIIYQDATVCNAISLIYGNED
                     IKCDMDGYLEMLNSRRANADN"
     CDS             complement(2034..2777)
                     /locus_tag="ctg149_3"
                     /transl_table=11
                     /translation="MSWSSYAHLPNSKDEYREILSQLKNGMSVDEVDNIIATVKGKEKV
                     THHYRNNLARIGIFNINQKKIFLNYEADRLKEDQEDNYLKMILSESVRRNRSWELNTVE
                     SVIHREKTYDIAVIAEYLTNEHPNIQKKNFIRWVRPIVNIFKIIDILPVTGHERILQEI
                     YLKLTNQYGKLVALEELDNELKKIDKSYEIVAFINDLLNDINMKFKIELLMLPDWATQN
                     KIYMINMEYYTHMKIKNSLLEGVSE"
     CDS             complement(2783..4126)
                     /locus_tag="ctg149_4"
                     /transl_table=11
                     /translation="MNLVKDYKQYFTPDKLAEYMVNMIPDDSIKTVIDLSMGECGLLEK
                     AKDRWPDARLYGADIDEELILKINKDSPYIKTFHGDSLSSDLENWKSYNKIVKKRGFDL
                     AIANPPFDFYKQSEVDINQNEKKIMPIEIRFLYQYIDIVKENGYICIILPYGFLSLDLY
                     KEIRRQLPEKVTIIKIMKIFNTCFKKIDADTCLMLMKKKKKQKISQSYINVQYLDSDYE
                     LSVCQNVQISETDRWDLEYQSLLKNSDIFTQNVKMKKDILGNYIQECRRGKSITNNKEL
                     LADKGIRYIHTTDLQKLYITNKNKRYVSNDKEFFGKAVLSENMVLIGRVGKGCLGKTGI
                     VLKSYSGMFFSDCIYAVRLQNINPYYVTLFLASEFGQMQLKGIAKGSCSKYITQEGLFN
                     ICILIPDRELQDYYGNEYKKLISRPGPKNEIIFADLVEKLNQTIRKER"
     CDS             complement(4319..5395)
                     /locus_tag="ctg149_5"
                     /transl_table=11
                     /translation="MSELSFEQMLEDSVKTIRNGEIVQGTVIDVKEDEIILNIGYKADG
                     IITKNEYSNDASLVLTDAVHVGDTMEAKVLKVNDGEGQVTLTYKRLAAEKGNKRLEEAF
                     ENQEVLKAPVTQVLDGGLCVNVDEARVFIPASLVSDTYEKDLSKYADQEIEFVITEFNP
                     RRRRIIGNRKQLLLAEKAEKQKELMEKIHVGDTVEGTVKNVTDFGAFIDLGGADGLLHI
                     SEMSWGRVENPKKVFTVGETLKVLIKEINGDKIALSLKFPEANPWLTAAEDFAVGNVVK
                     GKVARMTDFGAFVELAPGVDALLHVSQISREHVAKPADVLSIGQEIEAKVVDFNGEDKK
                     ISLSMKALEAPAEEATEE"
     CDS             complement(5376..6254)
                     /locus_tag="ctg149_6"
                     /transl_table=11
                     /translation="MKVKVAETAGFCFGVKRAVNKVYELIDTEQKPIFTLGPIIHNEGV
                     VADLEARGVHVIAEADLDSPDDTLQNGTVVIRSHGVGKAIYDKLKEKNISYVDVTCPFV
                     LKIHRIVEKESLAGNHIIIIGDKDHPEVQGICGWCQGPYTVIRNQEEAEAFVPPKGKKI
                     SIVSQTTFNYNKFKDLVEILCKKRYDNNVLNILNILNTICNATEERQREAKNIAGEVDT
                     MLVVGGRHSSNTQKLFEICKKECGNTYYIQTPVDLDSEMFQCSSYVGITAGASTPNKII
                     EEVQEHVRIKF"
     CDS             complement(6273..6944)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Cytidylate_kin"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg149_7"
                     /sec_met_domain="Cytidylate_kin (E-value: 3.8e-78,
                     bitscore: 251.8, seeds: 12, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MGCNIAIDGPAGAGKSTIAKKVAKELSFIYVDTGAMYRAMALYLL
                     NHGVNGENQEEIEAVCSGADISIEYKNGEQIVILNGENVNTMIRTEQVGNMASKSSANP
                     KVRAHLLKLQRTLAEKNDVVMDGRDIGTTILPNAEVKIYLTASADTRAKRRALEYEQKG
                     EAFDLDQIRKDIIERDERDMNREISPLKQAEDAVLVDSSEMGIDDVVNAILNVYKEKVQ
                     K"
     CDS             complement(7130..8578)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) HI0933_like"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg149_8"
                     /sec_met_domain="HI0933_like (E-value: 1.4e-128, bitscore:
                     418.8, seeds: 46, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MLPVVHIYIDRSEAETWNHDEIDNLQGKINTGEYSMSKVIIIGGG
                     AAGMMAGVFAARNHHEVHILEKNEKLGKKVFITGKGRCNVTNACDTEELFPAMMSNPKF
                     LYSSFYSFTPQDVMEFFEKAGVPLKVERGNRVFPQSDHSSDIIRALERELKKAGAKIHL
                     HTAVQEIVKKPVTDSANTLESEATLTESGFDAGKGRKGKKSPDVPQEKITGVILTDGTF
                     MEGDAVIVATGGFSYQSTGSTGDGYRFARELGLKVTDIAPSLVPLKTKEDYVPKLQGLS
                     LKNTGLTIKNGKKVLYEDFGEMMFTHFGVTGPMILSASAHIGAKLAKAPNGELSAYLDL
                     KPALTREQLDARILREFEAGPNKQFKNVIGVLFPSSLTPVMLELGGIPAEKKIHDISRE
                     ERQHFIDLIKAFPFTITGMGEFKEAIITRGGVSVKEINPGTMESKKISGLYFAGEVLDL
                     DAVTGGYNLQIAWSTAYLAAQAIQ"
     CDS             complement(8690..10102)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: PYC_OADA"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: HMGL-like"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg149_9"
                     /sec_met_domain="HMGL-like (E-value: 6.6e-47, bitscore:
                     150.0, seeds: 15, tool: rule-based-clusters)"
                     /sec_met_domain="PYC_OADA (E-value: 5.2e-59, bitscore:
                     189.1, seeds: 434, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAELEKKPVKIVETILRDAHQSQIATRMTTEQMLPIVDKLDKVGY
                     HAVECWGGATFDASLRFLHEDPWERLRKLRDGFKNTKLQMLFRGQNILGYRPYADDVVE
                     YFVQKSAANGIDIIRIFDCLNDLRNLQTAVSAANKEKAHAQVALSYTLGDAYTMEYWTD
                     IAKRIEDMGADSICIKDMAGLLLPNKATELVTALKETVKIPIDLHTHYTSGVASMTYLK
                     AVEAGVDIIDTAMSPFALGTSQPATEVMVETFKDTPYDTGFDQKLLSEIADYFRPIRDE
                     ALDSGLLNPKNLGVNIKTLLYQVPGGMLSNLTSQLKEQHAEDKFYDVLEEVPRVRKDLG
                     EPPLVTPSSQIVGTQAVFNVLMGERYKMVTKETKDILLGKYGATVKPFNPEVQKKCIGD
                     EKPITCRPADLLDNELEKLESEMAQYKEQDEDVLTYALFPQVAMDFFKYRQAQKTKVDE
                     KAADKKNGAYPV"
     CDS             complement(10255..11403)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: OAD_beta"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg149_10"
                     /sec_met_domain="OAD_beta (E-value: 5.4e-157, bitscore:
                     511.9, seeds: 229, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSYVTETLSNLIHQTAFFNLTWGNYLMIAVACVFLYLAIKKGFEP
                     LLLVPIAFGMLLVNIYPDIMANPEDMSNGVGGLLHYFYILDEWSILPSLIFMGVGAMTD
                     FGPLIANPISFLMGAAAQLGIYAAYFLAIFLGFNGKAAAAISIIGGADGPTSIFLAGKL
                     GQSALMGPIAVAAYSYMSLVPIIQPPIMKLCTTEKERKIKMDQLRPVSKLEKILFPIVI
                     TIVVCLILPTTAPLVGMLMLGNLFRECGVVKQLTETASNALMYIVVILLGTSVGASTSA
                     EAFLNADTLKIVVLGLVAFAIGTFGGCMLGKLLCKLTHGKINPLIGSAGVSAVPMAARV
                     SQKVGAEADPTNFLLMHAMGPNVAGVIGTAVAAGTFMAIFGV"
     CDS             complement(11420..11788)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: Biotin_lipoyl"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1024:Biotin-requiring enzyme (Score: 63.1; E-value:
                     5.3e-20)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg149_11"
                     /sec_met_domain="Biotin_lipoyl (E-value: 1.1e-20, bitscore:
                     63.1, seeds: 40, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKSYTITVNGTAYEVTVEETGSVSAPAAAPKAAPKAAPAAAPKAA
                     APAAGAGAVKVTASVPGKVVKVAASVGQAVKAGDSVIILESMKMEIPVVAPQDGTIASI
                     DVAEGASVENGDTLATMN"
     CDS             complement(11886..12644)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: OAD_gamma"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg149_12"
                     /sec_met_domain="OAD_gamma (E-value: 1e-26, bitscore: 83.3,
                     seeds: 234, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKMIKKITSVFMTFLVMAALVIGSTSVVFAADKVDDTVKSTLVTT
                     AEGLTDAIVQLKDEEIENYMSSGDDFTTSAMQSWQTSKDELGAKKDSNGETTVTFKDDQ
                     YTVTVPLKFEKAEANFVYVFDSQGTPISMTVDVQYGMGKTLQRAGLNTLMGIGTVFVML
                     VLLSLLISLFRFIPNPEAKKAAEAKAAKAAKEAEAAAIAAAAPAQTAEENLADDGELVA
                     VIAAAIAAAEGTTTDGFVVRSIHKVKRNRR"
     CDS             complement(12659..14095)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: CT_Vparvula"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg149_13"
                     /sec_met_domain="CT_Vparvula (E-value: 8.8e-137, bitscore:
                     446.4, seeds: 132, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSNATQSLAGTRITSLLDANSFVEIGQGVTARSTDFNMTANKAPS
                     DGVITGYGVIDDKLVYVYSQDVSVLNGTVGEMHAKKITRLYDLAMKTGAPVIGLVDCAG
                     IRLQEATDALEAFGQIYLKQTLASGVIPQITAIFGTCGGGMAVIPSLTDFTFMESKKGK
                     MFVNTPNALEGNNTDKCDTAAADFQSKETGVIDGVGTEDEILGQIRSLVSLLPSNNEDT
                     DNYTECTDDLNRVCADLANCAGDTAIALSQIADNGEFFETKADYAKDMVTGFIRLNGAT
                     VGAVANRSEVYDAEGKKVETFDGSISARGARKAADFVKFCDAFDIPVLTLTNATGFMAT
                     LCSEKMMAKSVGELVAAFADATVPKVNVIIGKAYGTAYVAMNSKSIGADLVYAWDNAEI
                     GMMDASLAAKIMYADADAAELNEKAAQYRELQNGVASAAARGYVDTVISPADTRKYVIG
                     AFEMLFTKREDRPSKKHGTV"
ORIGIN
        1 agctcctgcc cggcaggtcg tttccaagga agaaattgaa atccaaggga cgttcacatt
       61 tccgaaataa aaaagcttct ttttaaaata gagccagcat tcatcaatag gcttatttaa
      121 gtgcggcaat ttttatgaat cttctgtttt gtcctgaaat catgaaacag gcactcgtca
      181 tttggattat tattctcttc atatttctta atatattctg ttaattcttc aggcgctgaa
      241 aggagaaact taaagtccgg atctatttcc tgcagccaga aacggatatc aataggctgc
      301 tgctcagtta aatctatttc caactgatat tttataatct gtgtttcatt tatatcgtcg
      361 tacttaaatc caatatcacc tatcgaaaat aacagatcat cacctgtatt ctttaccact
      421 ttaattgtcc gcatttgctc tccttgaatt caacatctcc agataaccat ccatatcaca
      481 ctttatatct tcattcccat atatcaggct tattgcgtta cacactgtag catcctgata
      541 aataatgatt ttaatttttt ccttttcttc tgtcagtttc ccaatctgtc ctattgatag
      601 agccggataa ataagatatc ccttttcttc ttttaaattt tcctctaata atctcagcct
      661 tttttccaga tctttcttcg acggattatc tgtcgcaaca atatgatatc ttttcattat
      721 gttatcttta tttgttacgt attctcccct ttttttgctt cgtgaaatta tattttcttt
      781 cgaaatttcc attacctttt cgctcatttc acataacata gtttttctgg atatcgaagt
      841 tgcatttttc cacgccatat gtttttttat gctgttggat gtcagccgtg tcaccctgcg
      901 ctctttctcc tcttttttat cagacatttt ttttctatat tgttccagca cctgcataat
      961 tacctgtgta tatgctctgt aattggtttt ttcttttatt tccggagcac tgcaaattgc
     1021 ataaaacata gcttttttgt tctctccaaa agaaatctca taatattttt catatctttt
     1081 taagatcatt tcaaacaaac tgtatacttc ttctctggaa gatatatccg caatctgata
     1141 tgtcagattc gcctttcttg atttaaaagc ggggtcatct gaactttctg attttttatc
     1201 cgcagaaata ctttccgcaa atacaaaaaa catatttcca aatgtttcaa tattatcagt
     1261 aaaaagttta atatcttcaa acagattttt tctatctgtt ttgttcttcc aggagaaaac
     1321 atgctcatat tcatcaaaaa caattatcag ataattgttt atccatttca ggtattctgc
     1381 aaccatctca atgacgtcat aataaaattg accatccaga tctgatttcc tgaagttaaa
     1441 ttttttaaga tgttcaggca gatagtttcc tttgagaatg gaaaccgcct gaatctgtga
     1501 aacaacatcc ttacctcttg ccgcttcgta taatatcaga gcaagggccg atcctatgga
     1561 atatttctct tgtaaagcaa atataatgga tgctttatta ttagataatg catctttttc
     1621 tgctatgcca acaaaaagat ccgcacagtc cttgagcatt ctctgactaa cgctctctaa
     1681 aacttttctc tttaaatccg ttttttcctg ttttaatgaa acttttctgg caataatatt
     1741 ttcatactct tcaaaaaaac tatagatcat tcttatgaaa tgagattttc catttccata
     1801 gttgcttttc agaaaaatta tttccagccc ctgtgcttta tttttgtcaa aaaaaacaga
     1861 aaatctttct ataattttct gctttagttc ctcttgattc accaaaaaag agggggtctc
     1921 aggagctgtt cccatggaaa agtgtttcag ttcaatgccg agttctttca tagtcaggct
     1981 atcaaacctg tcattgaaca tttttttgca atcatctgca gatatttttt tcttcattcg
     2041 cttactccct ccaacaagct gttttttatt ttcatgtgcg tataatattc catgtttatc
     2101 atatatattt tattttgagt cgcccagtcc ggtaacataa gtagctcaat tttaaatttc
     2161 atatttatat cattcagtaa atcattaata aatgcaacaa tttcatagct cttatctatt
     2221 ttcttcagtt cattatcaag ctcttccaat gcaacaagct ttccatattg attcgttaat
     2281 tttaaatata tttcctgaag aattctctca tgacccgtaa ccggcagaat atcaataatc
     2341 ttaaatatat taacaatggg tctgacccat cttataaaat ttttcttttg tatattcgga
     2401 tgttcatttg tcagatattc tgcaataact gctatatcat atgttttttc tctgtgaatg
     2461 acagattcta ctgtattcaa ttcccaactt ctatttcgtc tgacagattc tgataatatc
     2521 attttcagat agttgtcttc ctgatcttct tttagccggt ctgcttcgta attcagaaat
     2581 atttttttct gatttatatt aaatattccg attctggcaa gattgttccg ataatgatgc
     2641 gtaacttttt ctttaccctt tactgttgca attatattgt caacttcatc tacgctcatt
     2701 ccgtttttca attgagataa aatctcccga tattcatctt tgctgttagg taaatgcgca
     2761 tatgatgacc atgacattgt ttttatcgct cctttcttat cgtctgattc aatttctcta
     2821 ctaaatctgc aaatattatt tcatttttgg gacctgggcg ggatattagc tttttatatt
     2881 cgtttccata atagtcctgg agttctctgt caggaatcag tatacaaata ttaaatagcc
     2941 cttcctgtgt gatgtattta ctgcaggatc cttttgcaat cccttttagc tgcatctgtc
     3001 cgaattcaga tgccagaaag agtgttacat aataaggatt aatattctgc aatcttaccg
     3061 cataaatgca gtcgctgaaa aacattccgg aataactttt taatacaatt cctgtttttc
     3121 cgaggcatcc ctttccaact cttcctatca gcaccatatt ttcgcttaaa acagcttttc
     3181 caaaaaattc tttatcgtta gatacatacc gtttattttt attggtaata tataatttct
     3241 gtaaatctgt agtatgaatg tatcttattc ctttgtctgc cagtaattct ttattatttg
     3301 taatggattt tcctcttctg cattcctgta tataattccc cagaatatcc tttttcattt
     3361 ttacattttg ggtaaatata tctgaatttt tcaataacga ctgatattcc aaatcccatc
     3421 tgtccgtttc acttatctga acattctgac acacagacaa ttcataatca ctatccaaat
     3481 actgtacatt tatatatgac tggctaatct tctgtttctt ttttttcttc attaacatca
     3541 gacaggtatc tgcatcaatt tttttaaaac aggtattaaa aatcttcatt attttaataa
     3601 tcgtaacttt ctctggcagc tgtctgcgta tctctttata taaatccaat gacagaaatc
     3661 catatggaag aatgatacag atataaccat tttcttttac tatatcaata tattgatata
     3721 ggaatcgaat ttctattggc ataattttct tttcattttg attaatatca acttcggatt
     3781 gtttataaaa atcaaaagga ggatttgcta tagccaggtc aaatcctcgt ttttttacta
     3841 ttttattata gcttttccag ttttcaagat cagatgacaa actatctcca tggaaagttt
     3901 ttatatatgg actgtcttta ttaattttca aaatcaattc ttcatcaata tcagctccat
     3961 acagtcgggc atccggccaa cgatcttttg ctttttcaag cagaccacat tcccccatag
     4021 agaggtctat tactgttttt atactgtcat ccggtatcat gttaaccata tattcagcca
     4081 gtttatccgg agtaaaatac tgtttataat cttttacaag attcattgtg tattcctttt
     4141 cttcttagca aggtatagat tactgtcagg cggatatatg catccgcatt cggctaaaat
     4201 aatagtatca taaaaatatt ttttcgtaaa gaaaaaaccg tctgtataag atcactctta
     4261 tacagacggt acttctcaat ttaatctgac cttatataat taataagtca cacagatatt
     4321 attcttctgt agcttcctca gccggtgctt caagagcttt catgctcagg ctgatcttct
     4381 tgtcttcgcc gttgaagtca acaactttag cttcgatctc ctgtccgatt gacagtacgt
     4441 ctgctggttt tgcaacgtgc tctctggaga tctgagatac gtgaagaagc gcatctacac
     4501 ctggtgcaag ttctacgaat gcgccgaagt ctgtcatacg tgcaacttta ccttttacta
     4561 cgtttcctac agcgaagtcc tcagctgctg tgagccatgg atttgcttcc gggaatttga
     4621 gggaaagtgc aatcttgtct ccgttgatct ctttgataag aactttaagt gtttcgccaa
     4681 ctgtgaatac tttcttcggg ttctctactc taccccagga catttcggag atgtgaagaa
     4741 gtccgtcagc tccgccgaga tcgatgaatg caccgaaatc tgtaacgttc ttaacagttc
     4801 cttcaactgt atcacctaca tggattttct ccattaattc tttctgtttc tctgctttct
     4861 cagcaagaag aagctgctta cggttaccga tgatgcggcg tcttctcggg ttgaattctg
     4921 tgattacgaa ttcgatctcc tgatctgcat atttggaaag gtctttctca tatgtgtcgg
     4981 atacgaggct tgcaggaatg aatactcttg cttcgtctac gtttacacaa agtccgccat
     5041 cgagtacctg agttacagga gcttttaata cttcctgatt ctcaaatgct tcttcaagac
     5101 gtttgttgcc tttctctgct gccagtctct tataagtaag agttacctga ccttctccat
     5161 cgtttacttt gagaactttt gcttccattg tgtcgccaac gtgaacagca tcagtgagta
     5221 caaggcttgc atcgttagag tattcgttct ttgtgataat accgtctgct ttataaccga
     5281 tattcagaat aatctcatct tcttttacat cgatgacagt accctgtaca atctctccat
     5341 ttctgatagt ctttacggaa tcttccagca tttgttcaaa acttaattct gacatgttct
     5401 tgaacctcct caataatttt gtttggggtg gaagcccctg ctgtaatacc tacataacta
     5461 ctgcattgga acatttcaga atccaagtct acaggtgttt gtatatagta agtatttcca
     5521 cattcctttt tacatatttc aaacagcttt tgagtattgg aactatgccg gccgcctacg
     5581 accaacatag tgtctacctc tccggctatg ttttttgctt ctctctgccg ttcttcggta
     5641 gcattacaaa tagtgtttaa aatattgaga atatttaaaa cattattatc atacctcttt
     5701 ttgcaaagaa tttcaactaa atctttaaat ttgttgtaat taaatgtcgt ctgggacaca
     5761 atgcttattt ttttgccttt tgggggtaca aatgcttcgg cttcttcctg gtttctgatc
     5821 accgtgtacg gtccctgaca ccagccgcag atgccctgta cttcggggtg gtctttgtcg
     5881 ccgatgatga tgatgtggtt tcctgcaagg ctttcttttt ccacgatcct gtggattttc
     5941 agaacgaagg ggcaggtcac atctacataa gagatgtttt tttctttcag cttatcgtag
     6001 atggctttgc ctacaccgtg agagcggatg actactgttc cgttctgcag ggtatcatcc
     6061 ggggaatcca ggtctgcttc tgcgataaca tggacgccac gagcttccag atccgctact
     6121 acgccttcgt tgtggatgat cgggcccaga gtgaaaatag gtttctgttc tgtgtctatg
     6181 agttcgtaga ctttgttcac tgcacgtttg acgccgaagc agaagcctgc tgtttctgct
     6241 acttttactt tcataaaata atccttctta aattatttct gcactttttc cttatataca
     6301 ttaagaatcg catttacaac atcatcaatt cccatttccg aagaatctac aagcactgcg
     6361 tcctctgcct gtttcagagg ggagatttcg cggttcatgt cgcgttcgtc gcgctcgatg
     6421 atgtcttttc ggatctggtc caggtcaaag gcttctccct tctgttcata ttccagtgct
     6481 cttctttttg ctctggtgtc tgcgcttgct gtgaggtaga tttttacttc tgcgtttgga
     6541 aggatggttg tgccgatatc tctgccgtcc atgactacat cgtttttctc tgccagagtt
     6601 ctctgaagtt tcagaaggtg ggctctgact ttcgggtttg cggagctttt ggatgccatg
     6661 tttcctacct gttcggtgcg gatcatagta tttacgttct ctccgttgag gatgacaatc
     6721 tgttctccgt ttttgtattc gatggaaatg tcagcgccgg aacatacagc ctcgatctct
     6781 tcctgatttt ctccgtttac gccatggttc agaagatata aagccattgc cctgtacatg
     6841 gctcctgtat ctacatagat aaatgataat tctttcgcta ctttctttgc gatggtgctc
     6901 tttcctgctc ctgcaggtcc gtcgatggct atgttacatc ccatttttgt gattcctcct
     6961 gtttctatta ttcaaacaga ttttctctgt tttattatta atgtttatta atcagtcaag
     7021 cggatattcg caatccgctt cgctacttgc tcataaccga atcatagata taattcgcat
     7081 acacggtact catcatctgc ttgtttctgt tgtttctata gtaagcagct tactgtatag
     7141 cctgcgctgc cagatatgcg gtagaccagg cgatctgtaa gttatatcca cctgtcactg
     7201 catccagatc cagtacctcg cctgcgaagt aaagacctga gattttcttt gattccattg
     7261 ttccggggtt gatctctttg acagagacgc cgcctctggt gatgatggct tctttaaact
     7321 cacccattcc tgtgattgtg aaggggaaag ctttgataag gtcaatgaag tgctggcgtt
     7381 cttctctgga gatgtcgtgg attttcttct ctgcggggat tccacccagt tccagcatta
     7441 ccggagtcag agatgacggg aaaagtacgc caatcacgtt cttgaactgt ttgtttggtc
     7501 ctgcttcaaa ttcacgcagg atcctggcat ccagttgttc tctggtgagt gccggcttca
     7561 gatccagata tgcggacagt tcgccatttg gtgctttcgc cagttttgca ccaatgtggg
     7621 cactggcgga caggatcatg ggacctgtga ctccgaaatg ggtgaacatc atctctccga
     7681 aatcctcata gagtactttc tttccattct ttatggtaag tcctgtattc ttaagggaaa
     7741 gtccctgaag cttagggaca tagtcttctt ttgtctttaa tggcacaagg gagggagcaa
     7801 tgtctgtgac tttcagtccc agttctcttg cgaagcggta tccgtcacct gtggaaccgg
     7861 tactctgata agagaatccg ccggttgcca cgatgactgc atctccttcc atgaaggttc
     7921 cgtctgtaag gatgactcct gtgatcttct cctgcggtac gtcaggtgat ttttttcctt
     7981 ttctgccttt tcctgcatca aatcctgatt ctgttaatgt agcttctgat tccagggtat
     8041 ttgctgaatc tgttacaggt ttctttacaa tttcctgtac agcagtgtga agatgaatct
     8101 ttgctcctgc tttcttcaat tcacgttcca atgcgcggat gatgtctgag gaatggtcag
     8161 actgtgggaa tactctgttt ccacgctcta cctttagagg gacacctgct ttctcaaaga
     8221 actccattac atcctgaggg gtaaatgaat agaaactgct gtagaggaac ttgggattgc
     8281 tcatcattgc aggaaagagt tcttctgtgt cgcaggcatt tgtcacattg catctgcctt
     8341 ttcctgtgat gaagactttc tttcccagtt tctcgttctt ctctaatata tgaacttcat
     8401 gatggttacg ggctgcaaaa acccctgcca tcattccggc ggctccgccg ccgattatta
     8461 taactttgct catggaatat tctcctgtat ttattttacc ctgcagattg tctatttcat
     8521 catggttcca cgtctccgct tcgctacgat caatatagat atgtaccact ggcagcatat
     8581 acccattggc acattatatt cccgggtatc atattcttcc ataataacgc aaaggagcct
     8641 gcttgcgcaa gctccttttt tcgtttggac atatttaatt actgatcaat tatacaggat
     8701 atgctccgtt ctttttgtca gctgctttct cgtcaacttt tgttttctga gcctgacggt
     8761 atttgaagaa gtccatagct acctgtggga acagtgcgta tgttaatacg tcttcatcct
     8821 gttccttgta ctgagccatt tcgctctcaa gtttctcaag ctcgttgtca agaaggtctg
     8881 caggacggca tgtgatcggt ttctcatcgc cgatgcactt cttctgtact tccggattaa
     8941 acggttttac agttgcgccg tattttccta acaggatatc ttttgtttct tttgtaacca
     9001 ttttgtatct ctcgcccata agtacgttga atacagcctg tgtaccaacg atctgtgaag
     9061 acggagtaac aagtggcggt tcaccaaggt ctttacgtac acgcggaact tcctcgagaa
     9121 catcgtagaa tttgtcttct gcgtgctgtt ctttcagctg ggaagtcagg ttggagagca
     9181 taccgcccgg tacctggtac agtaaagttt tgatgttaac accaaggttc ttcggattga
     9241 gcagtccgct gtcaagagcc tcgtcacgga tcggacggaa gtagtcagcg atctcggaga
     9301 gaagtttctg atcaaatcct gtgtcgtatg gtgtatcctt gaatgtctca accataacct
     9361 ctgttgcagg ctgggatgtt cccagtgcaa atggagacat tgctgtatcg atgatatcca
     9421 cacctgcttc tactgctttt aagtaagtca tggaagctac acctgaggtg taatgtgtat
     9481 gaaggtcgat cgggatctta actgtttctt ttaatgctgt aacaagctct gtagctttgt
     9541 ttggaaggag aagacctgcc atatctttga tacagatgga atcagcgccc atatcttcga
     9601 tacgttttgc aatgtctgtc cagtattcca ttgtgtaagc atctcctaat gtataggaaa
     9661 gagctacctg tgcatgagcc ttctctttgt ttgcagcgct tacagctgtc tgcaggttac
     9721 gaaggtcatt gagacagtca aaaatacgga tgatgtcgat tccgtttgca gcagatttct
     9781 gtacgaagta ttctacaacg tcatctgcat atggacggta tccaaggatg ttctgtccac
     9841 ggaaaagcat ctgaagtttt gtgtttttga agccgtcacg taatttacga agtctttccc
     9901 atggatcttc gtggaggaaa cgaagggatg cgtcaaatgt tgcaccaccc cagcactcta
     9961 ctgcgtgata gccgacttta tcaagtttat ctacgatcgg aagcatctgt tctgtggtca
    10021 tacgtgttgc gatctgggac tgatgagcat cacggagaat ggtttccaca attttaacag
    10081 gttttttctc taattctgcc attattaaat ctcctttata gtttgttcga gtatattcca
    10141 tcggatattt gtgatttacg ttactgtacg ctcacaggca aatatctggt ttgccgctta
    10201 ccagaaggag ttaatactcc tcctgatacg ggcagatcat cttatcagat tttattatac
    10261 tccaaaaata gccatgaatg ttccggctgc tacggctgta ccgataacac cggcaacgtt
    10321 cggacccatt gcgtgcatca gaaggaagtt tgtaggatct gcctctgcac ccactttctg
    10381 ggatacacgg gctgccatag gtactgcgga tacacctgcg gaaccaatca gcgggttaat
    10441 ctttccgtga gtcagtttgc aaagcagttt accaagcata catccgccga atgtaccgat
    10501 tgcaaatgca acaagaccta aaactacgat cttcagagta tctgcgttta agaatgcttc
    10561 tgcacttgtg gaagcaccta cggatgtacc cagaaggata actacgatat acatcagggc
    10621 attggaagct gtttctgtca gctgttttac aacgccgcac tctctgaaca ggttaccaag
    10681 cataagcata ccaaccagag gagctgttgt aggcaggatc aggcagacaa cgattgtgat
    10741 aacgatcggg aaaagaatct tctccagttt ggaaaccgga cgaagctgat ccattttgat
    10801 cttacgttct ttctcagttg tgcagagttt catgataggc ggctggataa tcggaaccag
    10861 tgacatatag gaatatgctg ccactgcaat cggtcccatc agtgcagact gtccaagttt
    10921 acctgcaagg aaaatggagg tcggaccgtc agcaccaccg atgatggaga tagctgccgc
    10981 tgcttttccg ttgaatccaa ggaagattgc aaggaagtaa gctgcataga taccaagctg
    11041 tgctgcagca cccatcagga aactgatcgg gtttgcgata agcggaccga agtctgtcat
    11101 ggcacctaca cccatgaaga tcagagatgg taagatactc cactcatcaa ggatgtagaa
    11161 ataatgaaga agtccaccta caccgttaga catatcttcc gggtttgcca taatgtccgg
    11221 atagatattt acaagcagca taccgaatgc gataggaaca agcagaagcg gctcgaatcc
    11281 tttcttgata gcaaggtaaa ggaatacgca ggctactgcg atcatcaggt aattgcccca
    11341 tgtcagattg aagaatgctg tctggtgaat caggttggac aatgtttctg ttacataaga
    11401 catttgacta cctcccgtct tagttcattg ttgctaaagt atctccgttt tctacagagg
    11461 caccttctgc aacatcaatg cttgcgatag taccgtcctg aggagctact acagggattt
    11521 ccattttcat ggattcaaga ataattacgc tgtctccggc ttttactgcc tgtccaacgc
    11581 ttgctgctac tttaacaact ttaccaggta cggaagcagt tacttttact gcgcctgcgc
    11641 ctgctgcagg agctgctgct ttcggagctg ctgccggtgc tgctttaggt gcggccttcg
    11701 gagctgctgc tggtgcggat acgcttcctg tttcttcaac agttacttca tatgctgtac
    11761 catttactgt aattgtatag cttttcattt taaaatcctc ctaaataaat aacaattatt
    11821 agcgttcatt actttctcag taatgtaatc tacgatacgc aaaaatatta tcggatgaac
    11881 agtgattatc ttctgtttct ttttactttg tggatggaac gaactacgaa tccgtctgtt
    11941 gtagttcctt ctgctgctgc gattgctgct gcgataacag ctaccagttc tccgtcatct
    12001 gcaaggttct cttctgctgt ctgtgcagga gcggctgctg cgattgctgc tgcctctgct
    12061 tcttttgcag ccttggctgc ttttgcttct gctgctttct ttgcttccgg attcgggatg
    12121 aaacggaaca gagagatcag aagacttaat aaaaccagca ttacgaatac agttccaata
    12181 cccatcagag tattaagacc tgctctctga agagtcttac ccataccata ctgcacatct
    12241 acagtcatgg aaatcggtgt tccctgtgag tcaaagacat atacaaagtt tgcttctgct
    12301 ttctcaaatt taagaggaac agtaactgtg tactgatcat ctttgaaagt tacagtagtt
    12361 tcaccattgc tgtccttctt tgcgccaagt tcatccttgg atgtctgcca ggactgcatg
    12421 gcacttgttg taaagtcatc tcctgaactc atgtaattct cgatttcttc atctttaagc
    12481 tggacaatgg catctgtcag tccttctgct gtagttacca gtgtggactt aacagtatca
    12541 tcaaccttat ctgcggcaaa taccacagag gtgctgccga tcaccagcgc agccattacg
    12601 agaaatgtca tgaatacaga agttattttt ttgatcattt tcatatgcgt caccccgctt
    12661 agaccgttcc atgtttctta gacggacgat cttctctctt tgtgaacagc atctcaaatg
    12721 caccgattac atattttctt gtgtcagccg ggctgatcac agtgtcaaca tagcctcttg
    12781 ctgctgcgga agcaacacca ttctgaagct ctctgtactg agcagctttc tcattcagtt
    12841 cagcagcatc tgcatctgcg tacatgatct tggctgccag ggaagcatcc atcataccga
    12901 tctctgcgtt atcccatgca tatacaaggt ctgcaccgat agatttgctg ttcattgcca
    12961 cgtaagctgt accgtaagct ttgccgatga ttacgtttac cttcggaact gttgcgtctg
    13021 cgaatgcagc taccagttca cctacggatt tcgccatcat cttctcgctg cataaggttg
    13081 ccatgaagcc tgttgcgttt gtaagtgtaa gtaccggaat atcaaaagcg tcgcagaatt
    13141 tcacgaaatc tgctgctttt cttgcgcctc ttgcagagat gcttccgtca aatgtttcta
    13201 ctttcttacc ttctgcgtca tatacttcac ttctgtttgc aacagcacct actgtagcgc
    13261 cgtttaaacg gataaagcct gtaaccatgt cttttgcata gtctgctttt gtctcgaaga
    13321 attcaccgtt gtcagcgatc tgggaaagtg caattgctgt gtcacctgca cagtttgcaa
    13381 gatctgcgca tacgcggtta agatcatctg tacactctgt gtaattgtct gtgtcttcat
    13441 tattagaagg aagaagtgat actaaggaac ggatctggcc aagaatctca tcctctgtac
    13501 caacgccatc gatcacacct gtctctttgc tctggaaatc agctgctgct gtgtcgcatt
    13561 tgtctgtgtt gtttccttcc agtgcgtttg gtgtgttgac gaacattttt ccttttttgg
    13621 attccatgaa tgtgaaatct gtcagggacg ggataactgc cataccaccg ccgcatgttc
    13681 cgaagattgc tgtgatctgc gggatcacac cggatgccag tgtctgtttc agatagatct
    13741 gtccgaaagc ttccagtgcg tctgttgctt cctgaagacg gatacctgca cagtcaacaa
    13801 gtccgataac cggagcgcct gttttcatgg caagatcata aagtcttgtg atcttctttg
    13861 catgcatttc accaacagta ccgtttaata cagatacatc ctggctgtat acataaacca
    13921 gtttgtcatc gatcacacca tatccggtga taacaccgtc agatggtgcc ttgtttgcag
    13981 tcatgttgaa atctgtggat ctggctgtta caccctgtcc gatttcgaca aaactgtttg
    14041 cgtcaagcaa agaagtaatt cttgtgcctg ctaagctttg tgttgcatta ctcattcttg
    14101 tttgccctcc atctttatga gaatatttaa aagttaaccc aaaaatttag ccgattttaa
    14161 ttttaccttt tccggcagaa aatttcaaca tttatttgtc attttcgtta aaaatatagc
    14221 agaaaaattt gtcaggtttc tccaaatttt gttttttttg agcatttctt cctatttaaa
    14281 aggaaaaaca taatgaaaag cacttatcag catatttttt cacctctgac cgtaaaaaat
    14341 atgactgtca aaaaccgtat tgttatgatg cctatgggca caaaggatca tcgatggaac
    14401 tctggaagga agaaatatcc ttaatacact gactcagatg ggataccgtg aacctcacat
    14461 ggctaaagtc acgtgcttcc ggacgcttta ggcgtcagac t
//
