LOCUS       c00024_gnlPro..        16596 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|JDFNHJKK_45.
ACCESSION   c00024_gnlPro..
VERSION     c00024_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-04 00:59:08
            Original ID  :: gnl|Prokka|JDFNHJKK_45
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 16596
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..16596
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[988:6596]"
                     /cutoff="10000"
                     /detection_rule="(TPP_enzyme_C and not (PFL-like or
                     PFL_6_pcresol or PFL_9_tma or Gly_radical or Gly_430_pcre
                     or Gly_8-9_TMA or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and
                     minimum(2, [ALS_ss_C, AlaDh_PNT_C, Arginase, BKACE,
                     BcrAD_BadFG, Beta_elim_lyase, CPSase_L_D2, Cys_Met_Meta_PP,
                     ELFV_dehydrog, GRDB, Glu_syn_central, Glu_synthase,
                     Gly_reductase, HAAA1, HG2B1, HG2B2, HGD-D, HleuD1, HleuD2,
                     HleuS1, HleuS2, Homoserine_dh, ILVD_EDD, IlvC,
                     Lactoyl-CoA1, Lactoyl-CoA2, Lyase_aromatic, MAAL_C,
                     OKR_DC_1_5_lysine, OKR_DC_1_5_ornithine,
                     OKR_DC_1_7_arginine, OKR_DC_1_C, OTCace, PALP,
                     Proline_reductase, Sacchrp_dh_C, TPL, Thr_dehydrat_C, TnaA,
                     Urocanase]) and not (POR or POR_N or PFOR_II))"
                     /neighbourhood="10000"
                     /product="TPP_AA_metabolism"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      989..6596
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(TPP_enzyme_C and not (PFL-like or
                     PFL_6_pcresol or PFL_9_tma or Gly_radical or Gly_430_pcre
                     or Gly_8-9_TMA or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and
                     minimum(2, [ALS_ss_C, AlaDh_PNT_C, Arginase, BKACE,
                     BcrAD_BadFG, Beta_elim_lyase, CPSase_L_D2, Cys_Met_Meta_PP,
                     ELFV_dehydrog, GRDB, Glu_syn_central, Glu_synthase,
                     Gly_reductase, HAAA1, HG2B1, HG2B2, HGD-D, HleuD1, HleuD2,
                     HleuS1, HleuS2, Homoserine_dh, ILVD_EDD, IlvC,
                     Lactoyl-CoA1, Lactoyl-CoA2, Lyase_aromatic, MAAL_C,
                     OKR_DC_1_5_lysine, OKR_DC_1_5_ornithine,
                     OKR_DC_1_7_arginine, OKR_DC_1_C, OTCace, PALP,
                     Proline_reductase, Sacchrp_dh_C, TPL, Thr_dehydrat_C, TnaA,
                     Urocanase]) and not (POR or POR_N or PFOR_II))"
                     /neighbourhood="10000"
                     /product="TPP_AA_metabolism"
                     /protocluster_number="1"
     cand_cluster    1..16596
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(TPP_enzyme_C and not (PFL-like or
                     PFL_6_pcresol or PFL_9_tma or Gly_radical or Gly_430_pcre
                     or Gly_8-9_TMA or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and
                     minimum(2, [ALS_ss_C, AlaDh_PNT_C, Arginase, BKACE,
                     BcrAD_BadFG, Beta_elim_lyase, CPSase_L_D2, Cys_Met_Meta_PP,
                     ELFV_dehydrog, GRDB, Glu_syn_central, Glu_synthase,
                     Gly_reductase, HAAA1, HG2B1, HG2B2, HGD-D, HleuD1, HleuD2,
                     HleuS1, HleuS2, Homoserine_dh, ILVD_EDD, IlvC,
                     Lactoyl-CoA1, Lactoyl-CoA2, Lyase_aromatic, MAAL_C,
                     OKR_DC_1_5_lysine, OKR_DC_1_5_ornithine,
                     OKR_DC_1_7_arginine, OKR_DC_1_C, OTCace, PALP,
                     Proline_reductase, Sacchrp_dh_C, TPL, Thr_dehydrat_C, TnaA,
                     Urocanase]) and not (POR or POR_N or PFOR_II))"
                     /kind="single"
                     /product="TPP_AA_metabolism"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..16596
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="TPP_AA_metabolism"
                     /region_number="1"
                     /rules="(TPP_enzyme_C and not (PFL-like or PFL_6_pcresol or
                     PFL_9_tma or Gly_radical or Gly_430_pcre or Gly_8-9_TMA or
                     PFL_acetate1 or PFL_acetate2 or Gly_radical_scatole or
                     PFL_proline or PFL_toluene) and minimum(2, [ALS_ss_C,
                     AlaDh_PNT_C, Arginase, BKACE, BcrAD_BadFG, Beta_elim_lyase,
                     CPSase_L_D2, Cys_Met_Meta_PP, ELFV_dehydrog, GRDB,
                     Glu_syn_central, Glu_synthase, Gly_reductase, HAAA1, HG2B1,
                     HG2B2, HGD-D, HleuD1, HleuD2, HleuS1, HleuS2,
                     Homoserine_dh, ILVD_EDD, IlvC, Lactoyl-CoA1, Lactoyl-CoA2,
                     Lyase_aromatic, MAAL_C, OKR_DC_1_5_lysine,
                     OKR_DC_1_5_ornithine, OKR_DC_1_7_arginine, OKR_DC_1_C,
                     OTCace, PALP, Proline_reductase, Sacchrp_dh_C, TPL,
                     Thr_dehydrat_C, TnaA, Urocanase]) and not (POR or POR_N or
                     PFOR_II))"
                     /tool="gutsmash"
     CDS             989..2707
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: TPP_enzyme_C"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg24_1"
                     /sec_met_domain="TPP_enzyme_C (E-value: 3.4e-48, bitscore:
                     155.5, seeds: 323, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKQISGNKLLVKALKEEGVEYLFGYPGACTIDISDELYKQDDVKI
                     ILPRHEQALVHEADAYARTTGKVGVCLVTSGPGATNLVTGLATANYDSVPLVCFTGQVA
                     RHLIGNDAFQEVDIVGITRSITKYGVTVRRREDLGRIIKEAFYIARTGRPGPVLIDLPK
                     DVMAELGSAEYPKNVNIRGYKPNTDVHIGQLKRAIKLLNKAKRPLFLAGGGVVISRAHE
                     IFREVVEKTKVPVVTTVMGKGSIPTDHPLYIGNLGMHGAYAANMAVSNCDVLFSIGTRF
                     NDRITGKLHEFAPHAQIIHIDIDTASISRNIQVDIPIVADAKEAITKMNEYVQECSTDK
                     WLNLIKNWKEEHPLKMRPNDLLSPMDILKEINEQFENSIIVTDVGQHQMLVSQYAEITE
                     GKQMIMSGGLGTMGYGLPGGIGAKIGNPDRPVIVISGDGGVQMNIQELATAVLEELPVI
                     LCIFNNEYLGMVRQWQKLFYGKRYAMTNLRAGALSRRTEGMEYPQYTPDFIRLAESYRA
                     KGIRVTKKEEIAAAFEEAKKNTKAPTVIEFIIDPEEMVYPMIKPGGTLEDMIMDC"
     CDS             2725..3234
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: ALS_ss_C"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg24_2"
                     /sec_met_domain="ALS_ss_C (E-value: 3.2e-22, bitscore:
                     70.9, seeds: 685, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDKGMKKRWISLYVENQVGVLSKISGLFSGKSYNLDSLTVGTTED
                     PTVSRMTIATVSDDETFEQIKKQLNRMIEVIKVIDFTDVFVRMKEILYIKVFNCSKEDK
                     VELFQIAETFKAKVIDYGKDSLLLEFVQTATKNDAVVKLIKEEFHRIEVVRGGSVGIES
                     ISMMER"
     CDS             complement(3303..4559)
                     /locus_tag="ctg24_3"
                     /transl_table=11
                     /translation="VKSTERLIFHIDVNSAFLSWESARRVSQGLPDLREIPSCVGGNPK
                     KRTGIVVAKSIPAKKYGIQTGEPVAMALRKCPNLVIVPSDFELYDKCSRAFKAICASFA
                     PVMESFSIDEVFLDMTGTSLIYPDPVAAAHELKDKIHRELGFTVNVGISTNKLLAKMAS
                     DFQKPDRVHTLFPDEIPEKMWPLPIRNLLFLGKASEQKLLNQGIRTIGDLARERASNVQ
                     YWLGEKTGHQLWQYARGIDDSPVKAVPDEAKGFSVETTFNDDITSIEQVFPILLEQCDV
                     LATRMRRKDKKCNCISVTFRTLDFRNRSHQTKLENATDLTDEIYINATRLFKEFWKGQP
                     LRLIGVALTGLTDGTYEQMSLFEDTENKERRRKLDAAMDEIRMKFGNDKITRASIMNSN
                     TRIGRKAKAQMKNEKTEEP"
     CDS             5322..6035
                     /locus_tag="ctg24_4"
                     /transl_table=11
                     /translation="MYLSDIHTHSIASGHGTTCTISDMAKAASKKGLKLLGISDHGPGT
                     LASGTSSYFRSLPFYPRKRFGIDILYGVELNILDSAGHTDLSDELLNNLDYAIISMHRQ
                     NYRSGSVSQNTEAYINAIKHPAVKILGHCDDTHFPVDYETLARAALRENVIFEINEASL
                     APGGYRGDTRANAARILYLCQKYQLPVILSSDSHGKEHVGDFTYAEEFVHQLMFPETLI
                     LNNQLPKLKVFLQTR"
     CDS             6300..6596
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: ALS_ss_C"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg24_5"
                     /sec_met_domain="ALS_ss_C (E-value: 1.3e-21, bitscore:
                     68.9, seeds: 685, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIEVIKVIDFTDVFVRMKEILYIKVFNCSREDKAELFQIAETFQA
                     KVIDYGKDSLLLEFVQTATKNDAVVKLIKEEFHRIEVVHGGNVGIESISMMER"
     CDS             6945..7583
                     /locus_tag="ctg24_6"
                     /transl_table=11
                     /translation="MNTTTTTTTTAAAKRSSTLYMVELAMMIAIILLMSFTPLGYLRTP
                     GLSITLLTIPVAVGAIILGPKGGAVCGLAFGATSFYMAVTGSSAFAAALFNINPFGTFI
                     VCIVARVLEGWITGLIFAALYKSPAKKFSYYVASLACPLLNTFFFMGFLCLFFYNTDYI
                     QGIVSSLGVSNPVVFVAAFVGVQGLIEAGFCFVVGSIVSKALSVALKRA"
     CDS             7842..8807
                     /locus_tag="ctg24_7"
                     /transl_table=11
                     /translation="MSLLKEISITELSNLRIGHTSDHDAKTGVTVLYFPNGAKAGCDIS
                     GGGPASRETPLTSPVTADNPINAIVLSGGSAYGLAAADGVMNYLESQNIGYNTGAALVP
                     LVCQSCIYDLSYGNPKIRPTAKMGEEACRRAFAGTDTRTGNIGAGTGATVGKLYGMKQS
                     MKSGLGIAAVSVKNFQMAAIVVVNALGDIFSPQNGQKIAGLKTPDRSGFLDSVHELYRF
                     MTPHDQFTGNTTIGAVITNGAFSKAELNKIASMTRCAYARCINPVATMADGDSIYAASI
                     GDVSVDINMAGTLAAEVMAQAIQNAIHTSQIQDEEFLKYV"
     CDS             complement(9220..10404)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) MFS_1"
                     /gene_functions="transport (smcogs) SMCOG1058:Major
                     facilitator family (Score: 78.3; E-value: 1.8e-24)"
                     /gene_kind="transport"
                     /locus_tag="ctg24_8"
                     /sec_met_domain="MFS_1 (E-value: 2.1e-24, bitscore: 78.3,
                     seeds: 192, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKTNYNRTVQACFIGYVVQAIVNNFVPLLFLTFQGSYGISLQKIT
                     LLVTFNFGIQLLVDLASIGFVDRIGYRASMILAHAMAAAGLILLTVLPECLGDPFVGLL
                     IAVMIYAIGGGLLEVLVSPVVEACPTDNKEKAMSLLHSFYCWGHVGVVLLSTLFFRIFG
                     IANWKYMALVWALIPIANGILFTRVPIAPLLDEGEKGLTMGELFKKKIFWVLMLMMLCA
                     GASEQAVSQWASTLAEKSFGINKTIGDLAGPMAFAILMGSSRAFYGKFGDKINLERFMQ
                     YSAVLCMVSYLMIAFIPVPALGILGCAVCGLSVGIMWPGTFSMAAASVKRGGTALFALL
                     ALAGDVGCSSGPTYVGMISGALNDNLKLGIFAALIFPVLMIMGIKMIGSLQKYD"
     CDS             complement(10745..11509)
                     /locus_tag="ctg24_9"
                     /transl_table=11
                     /translation="MLNQFSRTELLLGKEAMNKLENSRVAVFGIGGVGGYVCEALVRSG
                     VGTFDLIDDDKVCLTNLNRQIIATRKTVGQYKTEVMRDRILDINPKADVRIHNCFYLPE
                     NAADFDFSEYDYVVDAVDTVTAKIELIMRAKEAGTPVISSMGAGNKLDASAFRVADIYK
                     TKVCPLAKVMRRELKKRGVKKLKVVYSEEQPIRPIEDMAISCRSHCICPPGATHKCTER
                     RDIPGSVAFVPSVVGLIIAGEVIKDLTAEYRR"
     CDS             complement(11503..11700)
                     /locus_tag="ctg24_10"
                     /transl_table=11
                     /translation="MQIMKRLLIKNKRKLWLWFLLLVFLFLACRAAYITGSKAEQTRNN
                     EVEERQADSRSIPNEMEILC"
     CDS             complement(11836..12522)
                     /locus_tag="ctg24_11"
                     /transl_table=11
                     /translation="MKTNEEEDSRHIFRGELALVIAVMINSLAVILMLYSGSGISAISS
                     VPYAFEKVFPVITLGTWTYIFQALLILSLMILRKKFVPAYLCSFLVGFAFSELLDVNEA
                     WINILPKTIPLRVLYFVISYLLICIGIALSNRCGLPIIPTDLFPRELSEIIKVKYSKIK
                     VSFDVICLMITACMTGLILGHINGLGIGTVMAAFTMGKVIGLIGDEMDKHFRFVNFTQH
                     CSLHVQ"
     CDS             complement(12691..14109)
                     /locus_tag="ctg24_12"
                     /transl_table=11
                     /translation="MRKTKIICTMGPSTDKGDVMEQLVREGMDVARFNFSHGPHDEQRG
                     RIQKLRELRKKYDRPVAALLDTKGPEIRLGCFKDGKVSLEEGQIFTFTNKDIEGTNECV
                     SITYKELYKDVQPGGHILVDDGLVDLEVQDIAGKDIVCKVINAGVIGDRKGVNVPGANL
                     KMPFISKKDHDDLLFGIQEGFDFVAASFTRTANDIREVRKILKENGGEEIQIIAKIENQ
                     QGVDNIDEIIEAADGIMIARGDMGVEIPPEYVPVIQQKIIQKVYTAGKPVITATQMLDS
                     MISHPRPTRAEATDVANAIFQGTSATMLSGETAAGKYPVQALQMMSRIAEHMEQNIDYN
                     TIFKKTDRNENPDITNAIAHATCLTAIDLKASAILAVTKSGSTAHMMSKHRPGCLIGAC
                     TSSERVLRQLNLSWGVYPMLIKEEYSSEILCLRAIEAAQKHKLVKVGDTIVFAGGVPLG
                     IPGRTNLIRVCTVE"
     CDS             complement(14362..14892)
                     /locus_tag="ctg24_13"
                     /transl_table=11
                     /translation="MNYNRLETSLIDVIKEEQAKLGYMKEKISLYYPLSSLNHFFGNET
                     DAAGMMEILKDFPSYIEEKFGEVAVSHRGDRFCFTVSEKASEYVHNNMKENEFIKALIE
                     LVGRHGCTIEEIKELFHSYSDKIITEPMDNEEFDVMIRFDDGSDPYYYCFKDEGCHIIY
                     HRFLPEDYADFGF"
ORIGIN
        1 gcagatacgc ctataatttt tgaaaattca tgtatagaat aatatttact caaagaatca
       61 actcctttca ataatattct actctaatat cttgcaaaac tcaacatgtg cttatatgat
      121 tttataattt atatttaact gttaataacc ttccaaacag ctgtattatt tattttttat
      181 atcagcaata tagaaatctg tcaattacat tactgttcac tccgttctca gtaacgtagc
      241 caaaattcat tcaggaacat aaattttaca gcaattatcc aaaacccggt tgacaatttc
      301 ctctctataa atgtataatg taacccaaga aaacatttgt ccaccctatt cggacaatga
      361 atatccctat atcagccaaa tgccatgaca gggaggagta cacaaccccg ggaagcacag
      421 agagaaagcg gtcggtgcga gcttttgtga acgaattgtg gaagtagccc ccgagcagtg
      481 aaccaaaccg catatccagt cagatgattc atagacccgg acagacatgc caagtaggct
      541 tcaacgtcag ttccacgtta caggaacaca gtatatcagt actgacaaag tgcagagcca
      601 gactctgaat acaggtggta ccgcggaaac attttcgccc tgggcaaaca agcccagggc
      661 gttttttact atattcagaa ttgtgggagc tgctttacag cgttctcagc agaatcagcg
      721 cagcgccatt ctgcccctgt atcagccaat acacagctca gaaatttatt tgtttggtgt
      781 gcatttgcag gagtcgtgta gatcttagtg cctagaaatc tgcgttgttc agaaaaatct
      841 cactgtctga gcgcagcgag tttgagattt ttctgaacgc ttttagcaga ttttcagaca
      901 cttagatcta ctaggctccg aaaccgcaca ccaaacaaat aaatttctga gcgtcctata
      961 cacatacaca aaggaggttt accaaaatat gaaacaaata tccggcaaca aactcttagt
     1021 caaagcctta aaagaagaag gcgtagaata cctcttcggc taccccggag cctgtaccat
     1081 cgacatcagt gacgaactct ataaacagga cgacgtcaaa atcatcctcc cccgtcacga
     1141 acaagccctt gtacacgaag ccgacgccta cgccagaacc accggcaaag tcggcgtatg
     1201 tctggtaacc agcggtcccg gagcaaccaa ccttgtaaca ggacttgcaa ccgccaacta
     1261 tgacagcgta cctcttgtat gcttcaccgg ccaggtagcc cgccacctca tcggcaacga
     1321 tgcatttcag gaagtagaca tcgtaggaat caccagaagc atcaccaaat acggcgttac
     1381 tgtccgcaga cgtgaagact tgggacgtat catcaaggaa gccttctaca ttgcccgcac
     1441 cggccgtccg ggacctgtcc tcatcgacct tccaaaggac gtcatggcag aacttggcag
     1501 cgcagaatat cctaaaaatg tcaacatccg cggttacaaa ccaaacacag atgtccacat
     1561 cggccagctc aaacgtgcca tcaaactttt aaataaagca aaacgtccct tattcctggc
     1621 aggcggcggt gtagtaatct cccgcgccca tgaaattttc cgggaagtag tggaaaagac
     1681 aaaagtaccg gttgtcacaa ccgtaatggg aaaaggctct atccccacag accatccgct
     1741 ctatatcgga aaccttggca tgcatggtgc ctatgcagca aatatggcag tcagcaactg
     1801 cgatgtgctg ttctccatcg gaaccagatt caatgacaga atcaccggaa aacttcatga
     1861 atttgcacca catgcccaga ttatccacat tgatattgat acagcatcca tttcccgaaa
     1921 cattcaggtg gatatcccca ttgttgctga tgcaaaagag gctatcacca aaatgaacga
     1981 atacgtccag gaatgttcaa cggacaagtg gcttaacctg atcaaaaact ggaaagaaga
     2041 gcatccgctt aaaatgcgtc caaatgatct tttaagtccg atggatatcc tgaaagagat
     2101 caacgaacag tttgagaaca gtattatcgt aacagatgta ggacagcatc agatgcttgt
     2161 ctcccagtat gcggaaatca cagagggcaa acagatgatc atgtccggtg gtctgggaac
     2221 aatgggctat ggtcttccag gcggcatcgg agccaaaatc ggaaatcccg acagacctgt
     2281 catcgttatc tccggtgacg gcggtgtgca gatgaacatt caggagcttg caactgcagt
     2341 tctggaagaa cttcctgtta tcctgtgcat ctttaacaat gaataccttg gaatggtacg
     2401 ccagtggcag aagcttttct acggcaaacg ctatgctatg accaatctgc gcgcaggagc
     2461 actttcccgc cgcactgaag gcatggaata tccacagtac acaccggatt tcatcagact
     2521 tgcagagagc tacagggcaa aaggaatccg tgtcacaaag aaagaggaaa ttgcagcagc
     2581 cttcgaggaa gcaaaaaaga acacaaaggc acctacagta attgaattca tcattgaccc
     2641 tgaggaaatg gtttatccta tgatcaaacc aggcggaact ctggaagata tgattatgga
     2701 ctgttgatca ggaggaaaat tattatggat aaaggaatga aaaaaagatg gatttctctc
     2761 tatgttgaga accaggtagg tgttctgtcc aaaatctccg gacttttctc cggaaaaagc
     2821 tacaatctgg acagtcttac tgtaggaact accgaggacc ccacagtatc tcgaatgact
     2881 atcgcaacag tcagtgatga tgaaactttt gagcagatca aaaaacagtt gaaccgtatg
     2941 atcgaggtta ttaaggttat tgatttcaca gacgtatttg tccgcatgaa agagattctg
     3001 tatattaagg tttttaactg ttccaaagaa gataaggttg aactgtttca gattgccgaa
     3061 accttcaagg caaaggtcat tgactatggc aaagacagcc tgctcctgga atttgtccag
     3121 acagcaacca agaatgacgc agtagtgaaa ctgatcaagg aagaatttca cagaattgaa
     3181 gtggtacgtg gaggaagtgt aggaatcgaa tctatcagta tgatggaacg ataaaacttt
     3241 ttctgaaatt tttataaagg gaggattgtc gcattattct taatgctcag tcctcccttt
     3301 acttacggtt cttctgtctt ttcgtttttc atctgtgctt tcgcttttcg cccaatccgt
     3361 gtattgctgt tcataatact ggcacgggtg atcttatcat ttccaaattt catccggatc
     3421 tcatccatag ctgcatccag ctttctgcgg cgttctttat tttccgtatc ttcaaacaga
     3481 gacatctgtt cataagtgcc atctgtaagg cctgtcagtg ccacaccaat cagacgtagc
     3541 ggctgtcctt tccagaattc tttaaaaagt cttgtagcat ttatataaat ttcatctgta
     3601 agatctgtag cattttccag ctttgtctgg tgtgaacggt ttctgaaatc caaagtacga
     3661 aaagtcacgg aaatacagtt gcatttctta tcttttctgc gcattctggt tgccagaaca
     3721 tcacactgct ccaaaagtat gggaaacacc tgctctatgg aagtaatatc atcgttaaaa
     3781 gtagtttcca cactgaaacc ttttgcctca tcaggcactg cttttacagg ggaatcatca
     3841 atacctctgg catattgcca tagctgatgt cccgtttttt ccccaagcca gtactgcaca
     3901 ttggatgctc tttctcttgc cagatcaccg atggtacgga tcccctgatt cagaagcttc
     3961 tgctcggaag cttttcccag aaacagcaga ttacggatag gaagaggcca cattttctct
     4021 ggaatttcat ccgggaacaa agtgtgtact ctgtccggct tctgaaaatc tgatgccatc
     4081 tttgccaaaa gcttattggt agaaattccc acatttactg tgaatcccag ctctctgtga
     4141 atcttgtctt tcagctcatg agcagcagct acagggtcag gatagatcag agaagtacct
     4201 gtcatatcca gaaatacctc atcaatggaa aaagattcca tcacaggtgc aaaggaagca
     4261 cagattgctt taaatgcccg ggaacattta tcgtataatt caaaatcact gggaacgatc
     4321 accaaattgg gacatttccg aagagccata gctactggct cgccggtctg gatcccgtat
     4381 ttttttgcag ggatagattt ggcaaccacg atacctgtcc gtttctttgg atttcctcct
     4441 acacaggaag gaatttctct gagatccggc aacccctggc tcacccttct ggctgattcc
     4501 caggaaagaa atgcactgtt tacatcaata tgaaaaatta accgttccgt acttttcact
     4561 gttcttcctc caatatatga attgcgctct tcatatctga tgatttcatt ttaccctgat
     4621 ctgctctcca gggtaagaac ctcgtttgtc caaaaaagtg tctttatttg catcatcttg
     4681 tctgagctgt tactgtattt atatttgttt gatttcactc tgctatcaga gttttgaaca
     4741 acaacgccgc acttgccata cggcagtgcg gcgtctgtat ttcgctaccg gtcacattgt
     4801 tcccggtaac tttttttact taattctgag gattcatttc ctctcgatat atacttatcg
     4861 attagtcata aaggttagga gcaatttctt cgctgtccat atttgtggaa tcataccagt
     4921 atccagttca gcctccagcc attcataaga gaattccggg aatgtctgat gtttgaaatt
     4981 tttccatgtt actcctttct catgaagtaa ctgtctacac ataagcaaac agtgccatcg
     5041 ctgtcattga tcagcaataa gcccccatgt tttcatatag ttccattata ccttctcatt
     5101 ttcccgaagt caacataatt taacatgtat cagccgttta tttgtgttgc tttttatttg
     5161 atttttgttg tatttcagtt gtttttattt tgtttcctca ttgacattta aatcctcatc
     5221 tgtcatactt gaatataacg aatgtaccat caaacagcag ctttgcatct tccgtaaggc
     5281 tcttatcata tatagaaacc gctctggaaa ggagacaaac aatgtatctt tctgacatcc
     5341 acacacattc tatcgccagc ggtcacggaa ccacctgtac catctctgac atggcaaaag
     5401 cagccagcaa aaaaggactg aaactccttg ggatttctga ccacggcccg ggaactctgg
     5461 cttccggaac ttcttcttat ttcagaagcc ttccttttta tcccagaaaa agattcggca
     5521 tagatattct ttacggagtt gaactaaaca tcctggacag tgcaggacat acagatctgt
     5581 cagatgaact gctgaacaac ctggattacg ctatcatcag tatgcatcgg cagaactacc
     5641 gttcaggctc tgtatctcag aatacagaag cttacatcaa tgcaataaaa catcctgctg
     5701 taaaaatact cggccactgc gacgatacac atttccctgt agattatgaa acgctggcaa
     5761 gagcagcttt acgggaaaat gttatttttg aaataaacga agcttccctc gcacccggag
     5821 gatatcgggg agacacaaga gccaatgcag ccagaatcct gtatctctgt cagaaatatc
     5881 agcttcctgt tattttgtcc agcgacagcc acggaaaaga acatgttgga gatttcacct
     5941 atgccgaaga attcgttcac cagctcatgt ttccggaaac tcttatcctt aacaaccagc
     6001 ttcccaaatt aaaagttttc cttcagacac gttaaaagaa tgttcctcaa agggacattc
     6061 ttttatttta tgcattgttt tttgcattgt gttattttgt ttattttcta taatttcttg
     6121 tcaaaaaaga cgacatttta gtacatttta attaacaaaa ctcacttaac catttacata
     6181 tctcgtgata gatcagtctt actgtaggaa ccaccgagga tcctacagta tcccgaatga
     6241 ctatcgcaac agtcagcgat gatgaaacct ttgaacagat caaaaaatag ttaaaccgca
     6301 tgatcgaggt tatcaaggta atcgacttca cagatgtatt tgtcagaatg aaagaaattc
     6361 tctacatcaa ggttttcaac tgctccaggg aagataaagc agaactgttt cagattgcag
     6421 aaaccttcca ggcaaaagtc attgactacg gcaaagacag cctgcttctg gaatttgtcc
     6481 agacagccac caagaatgat gcagttgtca aactgatcaa ggaagaattc cacagaattg
     6541 aagtggtaca tggtggaaac gtaggaattg aatccatcag catgatggaa cgctaaatct
     6601 cataatcaat attttttaca ggatatagaa acacctctat atcctgtatt tattttcaaa
     6661 catactataa aatattgcag tttttaatca aatgtgttat ggtttacggg agcgttattc
     6721 gaaagaaaat gcatctgttt tccacatctg acagtctggt ggataaagtc atccacttca
     6781 cagtctggtt aaattcgtga ggcgacctgt aaggcgtcta cacaccggaa atttttcttt
     6841 tgttctgatg catatttttc ataacgcctg atccccatac tctaaactgt ctgaaaagca
     6901 ggggacgcat tgcgccgttt tatcagacca aaaggagaat tcatatgaac acaacaacaa
     6961 ccactacaac aacggctgca gcaaaaagaa gcagcactct ttacatggta gagttggcta
     7021 tgatgatcgc cattattctg ctcatgtcct ttaccccgct gggctacctt cgtactcccg
     7081 gcttatccat cactcttctc accatcccgg tagctgtagg agctatcatc ctcggaccga
     7141 aaggtggtgc tgtatgcgga cttgctttcg gtgcaaccag cttctatatg gctgtcacag
     7201 gaagttcagc tttcgctgcc gcacttttta acattaatcc atttggcact tttattgtat
     7261 gtatcgtggc acgtgtgctg gaaggatgga tcacaggact tattttcgca gcattatata
     7321 aatcaccggc gaagaaattt tcctattacg ttgcttcact ggcatgcccg ttactgaata
     7381 ctttcttctt catgggcttt ttatgtctct tcttctacaa cacagattac attcagggta
     7441 ttgtttccag tcttggagta agcaatcctg ttgtcttcgt tgctgctttt gtgggcgttc
     7501 agggactgat cgaagcgggc ttctgctttg tagtgggaag tatcgtttcc aaggcacttt
     7561 ctgtggcact gaaacgtgca taatctttaa aagaacagcc ttttccaaaa aacctgacta
     7621 cattgtcacc gtagtcaggt ttttttatct ggcacattta aaacaggaat cctacctgat
     7681 tcaattaata tctatagcaa tctcacaaaa taatgcaatc aagacagttc agcagagtgc
     7741 gaaagacaag gaaaatatct gacgcagtac ttcacattct gataggctgg attgctctca
     7801 gtatttcata gaattgctat cacataataa aggagatttt tatgtcatta ttaaaagaga
     7861 tttctattac agagctttca aatttacgca tcggtcatac ttctgaccat gatgcgaaga
     7921 ccggtgtaac tgttctttat tttccaaatg gagcaaaagc aggctgcgat ataagcggag
     7981 gcggccctgc ttccagagaa actcctctca cctctcctgt cactgccgac aatcccatca
     8041 atgctattgt cttgtccgga ggttctgcct atggactggc tgctgctgac ggtgtaatga
     8101 actatcttga atcacaaaat atcggttata acaccggtgc agccctggtt cctcttgtat
     8161 gccagtcctg tatctatgac ctctcttacg gaaatcctaa aatacgtcca actgcaaaaa
     8221 tgggcgaaga agcctgccgt cgggcatttg caggaacaga taccagaacc ggaaatatcg
     8281 gtgcaggtac cggtgcaact gtgggaaaac tttacggtat gaaacagtcc atgaagtcag
     8341 gtcttggtat tgccgctgta tctgtgaaaa atttccagat ggctgcaatt gtcgttgtca
     8401 atgcactggg agatatcttt agtccacaaa atggtcagaa aattgcaggg ctgaaaacgc
     8461 ctgacagaag cgggtttctg gacagtgtcc acgaattata ccgctttatg acacctcatg
     8521 accagtttac cggcaatacc accatcggag ctgtgatcac caatggggca ttttcaaagg
     8581 ctgaactgaa taaaattgcc tctatgaccc gctgtgccta tgccagatgc atcaatcctg
     8641 tagcaactat ggctgacggc gattccatct atgctgccag cattggcgat gtttctgtag
     8701 atatcaatat ggcaggaact ctcgccgcag aagtcatggc tcaggctatc caaaatgcca
     8761 tccatacttc ccagatccag gatgaagaat ttctgaaata tgtataacag tccgctataa
     8821 aagcgcagag aaaaagtatc atctctgcgc ttttattctt cctgtctgtc ttcatttttc
     8881 atctgtgctc tggtttttct ccaagccaga gctgtacatt tgcttcccgt tcccttgcca
     8941 gatcaccaat agtacggatt ccctgattca gaagcttctg ctcggaggct tttcccagaa
     9001 ataacatgtt acggacagga agtggccaca ttttctccgg tatttcgtcc gggaacagcg
     9061 tgtgtactct gtccgtttct ttggatttcc tcccacacag gagggaatat ccctgagatc
     9121 cggcagcccc tggcttaccc ttctggctga ctcccaggaa agaaatgcgc tgtttacatc
     9181 aatatgaaaa attaatcgtt ccatactttt taatatatct caatcatatt tttgcagact
     9241 tccaatcatc ttaatcccca ttatcatcaa cacagggaaa atcaatgccg caaagattcc
     9301 aagtttcaga ttatcattca gtgctcctga aatcatcccc acataggttg gtccggatga
     9361 gcatcccaca tctccagcaa gggcaaggag ggcaaacagg gctgttccgc cacgctttac
     9421 tgaggcagcc gccatgctga aggttcctgg ccacataata cctacagaca gaccgcaaac
     9481 cgcacatcca aggattccca acgcaggtac cgggataaat gcgatcatca gataggaaac
     9541 catgcacaga actgcactgt attgcataaa gcgttccaga ttgattttat ctccaaattt
     9601 cccataaaat gcccttgagc ttcccataag aattgcaaac gccatgggac ctgccagatc
     9661 tccgatagtt ttattgattc caaagctttt ctcagccaga gtagaagccc actggcttac
     9721 cgcctgctca ctggctcctg cacagagcat cattaacatc agaacccaga agattttttt
     9781 cttaaaaagc tctcccatag tcagcccctt ttcaccctca tccagcagcg gagcaatggg
     9841 aactctggta aaaaggattc catttgcaat gggaatcaaa gcccacacca gcgccatata
     9901 tttccagttt gcaatcccga aaatacgaaa gaataatgta gaaagaagta ccactcccac
     9961 atgtccccag cagtaaaagg aatgaaggag actcattgct ttttccttat tatctgtagg
    10021 gcaggcttcc accacaggac ttaccagcac ctctagcaat ccgcctccga tggcatagat
    10081 cataactgca atgagaagtc ccacaaacgg atctcccagg cactccggca atactgtgag
    10141 caaaatcaga cctgcagccg ccattgcatg tgccaggatc atagatgcac gataacctat
    10201 tctgtccaca aatccaatcg atgccagatc taccagcaac tggatcccga aattaaatgt
    10261 aaccagaagt gtgatcttct gcagcgaaat cccataactg ccctgaaatg tcagaaacag
    10321 cagaggaacg aaattgttca caatggcctg cactacatat ccgataaaac aggcctgcac
    10381 tgttctgttg taatttgttt tcattcgata tgatatcctc caatctgaaa tttattagtt
    10441 actgagaacg gagtaagcag taacaattta ttacgctgat atcgttcagg cattctcatt
    10501 caccaaattc tgcaccttca cagttctatc aatcaataat gacagtgtat cacagattct
    10561 ttcttttttc tttcattata ttttgaaaat cctataaatt tttatgttat tttgactttt
    10621 tctcatataa caattctata cactctaaca ggtaatccat caatccaatt caaaatattt
    10681 cccgcaaaaa aagatgtgta ccataccatt tctgacacca tacacatctc aaaataaaca
    10741 cttcttatct tctgtactcc gcagtcaggt ctttaataac ctctcctgca ataatcagcc
    10801 cgacgacaga cggcacaaag gccacactcc ccggaatatc tctgcgctcc gtacacttat
    10861 gcgtagcacc tggaggacaa atacaatgcg acctgcagct gatcgccata tcttcaattg
    10921 gtctgatcgg ctgttcctct gaataaacaa ccttcagttt cttcacacca cgcttcttca
    10981 gctctctacg cataaccttc gccagcggac acaccttcgt cttatagata tccgccaccc
    11041 gaaacgcact ggcatccagc ttatttccgg cacccatact gctgataaca ggagtccctg
    11101 cctcctttgc acgcatgatc agttcaatct tcgcagtcac tgtgtccaca gcatctacca
    11161 cataatcata ctcactaaaa tcgaaatcag cagcattctc cggaagataa aaacagttat
    11221 ggattctcac atctgctttc ggattaatgt ccaggatcct gtcccgcatc acctctgttt
    11281 tatattgacc aacagttttc ctggtggcaa taatctgtct gttaagattc gtcaggcata
    11341 ctttgtcatc atcgatcaga tcaaaggtcc ccacaccgct tctgaccaat gcttcacata
    11401 catatcctcc aacccctccg attccaaaca ctgccacgcg ggagttctcc agtttattca
    11461 ttgcttcttt tcccagaaga agctctgttc ttgaaaattg attcaacata atatctccat
    11521 ttcattcggt attgaccgac tatctgcctg cctttcttct acttcattat ttctggtctg
    11581 ttctgctttg ctgcctgtaa tgtaagcagc tctgcatgcc agaaacaaaa aaacaaggag
    11641 cagaaaccaa agccagagct ttcttttgtt ttttatgagc aaccgtttca taatctgcat
    11701 cactattcct taatatatta ttttcagata ccagagttgc aacatacttc catcacagat
    11761 ttcttatgat atctttactt ctataatgcg tcaagtatat catagaaaga aaaatcctgc
    11821 aatgaagaaa ctctgttact gtacatgaag tgaacagtgc tgagtgaaat tcacaaaccg
    11881 gaagtgctta tccatctcat caccaatcaa tccaattact tttcccatgg taaatgccgc
    11941 catcactgtt ccgattccca gtccgttgat atgccccagg atcagccctg tcatacaggc
    12001 agtaatcatc agacagatca catcaaaaga aaccttgatc ttagaatatt tcacctttat
    12061 aatctctgac agttcacgag gaaacagatc tgtaggaata atcggcagac cgcatctgtt
    12121 agaaagtgcg atccctatac agatcagcag ataactgatc acaaaatata acactctgag
    12181 tggaattgtc tttggcagga tattgatcca tgcctcatta acatccaaaa gctcactgaa
    12241 tgcaaatcca accagaaaac tgcacagata agcaggtaca aatttttttc tcagtatcat
    12301 cagacttaag atcagaagtg cctgaaaaat ataagtccat gttcccagtg taattaccgg
    12361 aaatactttt tcaaatgcat aaggaacact ggatatggca gatattcctg aaccagaata
    12421 cagcatcaga ataacagcaa gactgttgat catgactgct atcaccaatg ccagctctcc
    12481 tctgaaaata tgtctcgaat cttcttcctc atttgttttc ataacaattc tctcctctaa
    12541 cacaagcaag ggactgctgt cagaaaatat tttctgtcat acttttctga cggcagaccc
    12601 ctgtgtcttt tacatcttat attttctgaa aatactattt tttatcgaat caggcaagtt
    12661 tcccacttca actactgata ttttcctgac ttactcaacc gtgcagacgc ggatcaggtt
    12721 tgttcttccc ggaattccaa gcggtacacc accggcaaat acaatagtgt caccaacttt
    12781 tacaagttta tgcttctgtg ctgcctcgat tgctctcagg caaaggatct cagaactgta
    12841 ttcttctttg atcagcatcg ggtaaacacc ccaggataga ttcagctggc gaagaactct
    12901 ctcagagctt gtacatgcac cgatcagaca tcctggtctg tgtttggaca tcatatgagc
    12961 tgtacttccg gattttgtca ctgcaaggat tgcactggcc ttcaagtcga ttgcggtcag
    13021 acaggttgca tgtgcgattg catttgtgat atccggattc tcatttctgt ctgttttctt
    13081 aaagattgta ttgtaatcaa tattctgctc catatgttct gcaatacggc tcatcatctg
    13141 aagtgcctgt accggatatt taccagctgc ggtttctcct gaaagcatag ttgcacttgt
    13201 tccctggaaa atcgcattgg caacgtctgt agcctctgca cgggttggtc tcggatgaga
    13261 gatcatggag tcaagcatct gtgttgctgt aataaccggt tttcctgctg tgtaaacttt
    13321 ctggatgatt ttctgctgga taacaggtac atattccggc gggatctcaa cacccatgtc
    13381 acctctggcg atcatgatgc catctgctgc ttcaataatc tcgtcgatat tgtcaacgcc
    13441 ctgctggttc tcaatctttg caatgatctg aatctcttca ccaccgtttt ctttcaggat
    13501 ttttcttact tcgcggatat cgtttgcagt acgtgtaaaa gatgctgcaa cgaaatcaaa
    13561 tccttcctgg ataccgaaga gaagatcatc atggtctttt ttactgatga atggcatctt
    13621 caggtttgca cccggaacat tgacaccctt cctgtcgcca atcacacctg cattaataac
    13681 cttgcagaca atgtcctttc ctgcgatgtc ctgaacctcc aggtctacaa gtccatcatc
    13741 aaccagaata tgtccgcccg gctgcacatc cttataaagc tctttataag taatgcttac
    13801 gcactcatta gttccttcaa tatctttatt tgtaaatgta aatatctgtc cttcttccag
    13861 agaaaccttg ccatccttga agcatccaag tctgatctcc ggtccctttg tatcaagaag
    13921 tgctgcaaca ggtctgtcat atttcttgcg aagttctctc agtttctgga tacggcctct
    13981 ctgctcatcg tgaggtccat gtgagaagtt gaaacgtgct acgtccattc cctctctcac
    14041 aagctgctcc ataacatcgc ccttatcagt agacggtccc attgtacaga taattttggt
    14101 ttttctcatt taatctttcc ctccaaactg tcaactcaat tttatctatt ttattcctgt
    14161 aaaataatgt aataaaatgt tacctgtttc tataaatgaa aacattaaat caaataaaaa
    14221 ttaccattat tgagactatc tgtcaatata gaatttcgac ttatttttgt tgatatttga
    14281 caaaaaaata acatactttt gttgcaaata tcacatatat ttttactgat ccgacagttg
    14341 gaaaattttc actcattctt atcagaatcc aaaatctgca tagtcttccg gcagaaatct
    14401 gtggtaaatg atatggcatc cttcatcttt aaaacaataa taataaggat ctgatccgtc
    14461 atcaaagcgg atcatcacat caaactcctc gttatccatt ggttcagtaa tgattttatc
    14521 tgaataagaa tggaacagtt ctttaatttc ctctatcgta catccatgtc tgccaaccag
    14581 ttcgatcaat gccttgataa attcattctc tttcatatta ttatgtacat attcggaagc
    14641 tttttccgaa acagtgaagc agaaacgatc tcctctgtgt gatactgcta cttcaccaaa
    14701 tttctcttct atataagaag gaaaatcttt taaaatctcc atcatgcctg cagcatccgt
    14761 ctcattgcca aagaaatgat tcagggaact gagcggataa taaaggctga tcttctcctt
    14821 catatatcca agcttcgcct gttcctcttt gatcacatcg atcagactgg tttctaatct
    14881 gttatagttc atttattttc cctcctgaaa atctatcctt ttgctttttc tggttaatat
    14941 tttatcagac attgcccgaa aatcaatgca tttctttttc aattgtacgc ccgccaaaac
    15001 aatttcaatg ttttcttttt catacaaaaa taaagagctt gcgaaactgt cctttttttc
    15061 tccctctgac aaataactct gactggataa aacaaaacag ataaaaccaa ccacttcgtt
    15121 gcttttttaa ccaaataact gcttgattcg gttaaaaaaa cagcgttccg aatattattt
    15181 atatccgaaa cgctgtcatt attccaatta tttcattatg tatttaatcc cagttcttac
    15241 gtccgtaacg aagtgtcaca tcatatattt ccttctggag tttctttgta agatctctct
    15301 tcttgattct ccacttccag ttcgtaccaa ctgtagatgg tttattcatt cggaatctgt
    15361 tgtccagtcc catatagtcc tgcattggga taacgcagac acgcgcagca ctgcgcatga
    15421 tcagactgat gaaacattta tacagttctt cttccggtgt tgcatgatca cacagataat
    15481 ctctcgccag ttttctctca gctgctgtga tgctcttcca ccatcccacg atagtttcat
    15541 tatcatgggt tcctgtatat gccacgcagt tctccggata attatgtggc agataatcac
    15601 tggcacatcc ggaatctctg gagtcaaacg caaattccag aaccttcatt cccgggaagc
    15661 cgctctcata taccagatga cgtacagaat ctgtcatata tcctaagtcc tctgcgataa
    15721 cctgcttcca tccaagcgcc tgttcgatct tacggaacag atcaattccg ggaccttttt
    15781 cccagtgtcc gcctcttgca tctttatctc cgtatggaat agagaaatat tcatcaaatc
    15841 cacggaaatg atcgattcgc acaacatcat acagtctgaa gcagtaactc attctggaaa
    15901 tccaccactg atatcctgta tttctgtgat aatcccagcg atacagcgga tttccccata
    15961 actgaccggt tgcagaaaat ccatccggag ggcatcctgc tactgccagc ggtacattat
    16021 cctgatccag ctggaacagc tccggatgcg cccatgcatc agcactgtcc attgcaacat
    16081 aaatcggaat atctccaatg atctggattc cttttgaatt tgcataggat ttcagtttca
    16141 tccactgctc atagaactta aactgcatat actgctggaa ttcaatatca aaatagagtt
    16201 cttcacgata ataatccatg gcattgttcc agcggagtct gatatcctca gcccatttgg
    16261 tccattctac accttcgaaa cggtctttta ctgccataaa cagagcataa tctgacagcc
    16321 accagctgtt ctctgctacg aatttctgat agtcaggatt cttgctgata tcactgttct
    16381 cgtatgcttt tctcagaaga ggataacggc ctttgtagat tttttcataa tctacctcat
    16441 caggcttctt tccccaatta actttctcgc agtctttctt atcaagaact ccttcttcca
    16501 caagtgtatc cagatcaata aaatatggat tacctgcaaa tgtagagaaa gactgatatg
    16561 gagaatctcc atagctggtc ggtcccaatg gcagaa
//
