LOCUS       gnlProkkaNEMGPHMC_303  16157 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|NEMGPHMC_303.
ACCESSION   gnlProkkaNEMGPHMC_303
VERSION     gnlProkkaNEMGPHMC_303
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2024-12-01 01:28:50
            Original ID  :: gnl|Prokka|NEMGPHMC_303
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 1973
            Orig. end    :: 18130
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..16157
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="True"
                     /core_location="[10000:16074]"
                     /cutoff="20000"
                     /detection_rule="(TIGR04223 or AgrB)"
                     /neighbourhood="10000"
                     /product="cyclic-lactone-autoinducer"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..16074
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(TIGR04223 or AgrB)"
                     /neighbourhood="10000"
                     /product="cyclic-lactone-autoinducer"
                     /protocluster_number="1"
     cand_cluster    1..16157
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(TIGR04223 or AgrB)"
                     /kind="single"
                     /product="cyclic-lactone-autoinducer"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..16157
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="cyclic-lactone-autoinducer"
                     /region_number="1"
                     /rules="(TIGR04223 or AgrB)"
                     /tool="antismash"
     CDS             2758..3006
                     /locus_tag="ctg233_2"
                     /transl_table=11
                     /translation="MDLAMNFDADECLVTAMFDKGNRNDTMEAIDHIIPFLKGDADMIG
                     LVCNTIRKLFCMSDEGYEVFLMDLEEYKMELEEEDEE"
     CDS             3003..3917
                     /locus_tag="ctg233_3"
                     /transl_table=11
                     /translation="MSTSQCAVYQVKDTPEYRDVRFRSYEKLKSEGRTVQIENYQQVYI
                     GRIQPGETPADIKLRLQKQRPKNFKGHSIGCSDVIIITDDGKTTAYYVNKDGFIIIPEF
                     LTIKSSSDTRLSIDTTGYEIEGKKGTWLAQDYILMNEKKWFLMEHEEYGTRAAYVILSE
                     EGTVVMNDCYNGFDEEARRNIQNFMQQQAEQAQQKQQEMQAQAQTGQTQSGETQKKKPE
                     LANWQKVMDNGEYLRNAEMAEEANYNMIDGLMNNTPKKKDKNAPRRSVLKRLRNHQKKI
                     ASQGKGQPQQQKAMEEEMERKKK"
     CDS             4065..4982
                     /locus_tag="ctg233_4"
                     /transl_table=11
                     /translation="MVNTSETKNEKLKNNEATVQVMKKPKTFAQQVEIIKEKGFIIDND
                     TECIGFLKQANYYRLSAYFLPFRKKDGTYFSNINFHRIQRIYEFDSRLRGVLFNYIEKV
                     ELYLRTQLAYYSGHVHGALGYMDVVIYNDRHNHEKFVKLLNVCIEENKSTSVVQHHKEK
                     YGGNFPIWVIVEFFSMGMLSYFYADLQSGDQKYLAKELYGTSVACLKSWLRCITDLRNR
                     CAHYSRLYYWSFPALPKMPRELETSPNRKLFSQILVLKLLYPDKKEWLNKVLIELKAIV
                     EEYENDISLRHIGFPEDWYEQLEK"
     CDS             complement(5032..6681)
                     /locus_tag="ctg233_5"
                     /transl_table=11
                     /translation="MAVIKHIANKNSDYGESERYLIFQHNEYTQKPILDEEGHMILREE
                     YYLDSLNCDPFSFASECQELNSYYHKNKNFNEIKSHHYIISFAPKDKDECGLTGERAQQ
                     LGLTFAKKNFPGHQALVCTHTDGHNESGNIHVHIVINSLRKYDIPQEPYMEFDCEAKAG
                     YKHHLSTAYLTHLKQEVMDMCQKEGLHQVDLLTPAERKITEKEYWAQRRGQEKLDKLNQ
                     EMKEDGITPKETRYQTEKQFLRDAIDDAASTARSPEEFSKILDEKYHIIFKISRNRYSY
                     LHPGRKKYITGRNLGTRYTEDFLLKAFEENTKSHKEQKEEILEQQSPNTSTDLPTVPFS
                     DTSAIPAPFIFIKSDLRLVIDLQTCIKAQQSEAYAQKVKLTNLKQMAQTVAYIQEHGYD
                     SLDDFHAALDQASYQTSASRKSLKDTEQQLKDVNEQIHFTGQYLAYKNVYADYRKSRNK
                     QKFSEEHRAELSLYDTALRTLKAKSGGNKLPSMKALYAEKDRLIELRDKQREVFSSHRD
                     YERELRTVAANIDMILGKNCKQQLQDRKEPNL"
     CDS             complement(6668..7045)
                     /locus_tag="ctg233_6"
                     /transl_table=11
                     /translation="MTRPKKEETLAKTKDVHLRMNETEYDLLAERAKANSMTVSDFVRS
                     ALDNQKVIIKYEITADVPEIKKLISEFGKIGSNLNQIVRYFNQGGILSSEMRNEIRKSL
                     RDIYEMKYKVMKMAGDFRGSN"
     CDS             complement(7366..7692)
                     /locus_tag="ctg233_7"
                     /transl_table=11
                     /translation="MNEETDFSAFIKNRITELRCQKGISEYTLSLAIGRSQGYIQSISS
                     GRILPSMNTFLDICKYFDITPTEFFDPSFQNPTLLHSIISDISKFSEEDLLLLSSVLKR
                     ITRN"
     CDS             7838..8605
                     /locus_tag="ctg233_8"
                     /transl_table=11
                     /translation="MSNTERVLYFPEGKIMKTIICDDEKSTCSELEEIILKYAKEKSVS
                     LVTEVFYSGDTLLDYLKREKINILFLDIELPGKDGVMVGKYIREVLEEENIFLIYISSK
                     ENYALQLFQNRPFDFLVKPIEAAKIYHVLDNIYRISGKNSVGFEFQTQNSTYRISYKDI
                     LYFQSTGRKINIVMKKEIRTFYGKLNEIEKRIPENVFLRIHKSYLVNKNYVKEFTYEWV
                     KMLNGDVLNISKINRADVRRKILESAADEFKNI"
     CDS             8586..9863
                     /locus_tag="ctg233_9"
                     /transl_table=11
                     /translation="MSLKIFNDIIVLLANALRFYALKHFVGIFVQKEESRWKHVSILYI
                     IGWAWTSAISLLFSSPAMNILSNITSLFLIFFPYRIKKTKKCLAVFVIYVINALVDSIV
                     ILSLTKYTMGQPVNQVCECITSFALLFIAIIIQRTTEPEKEITLPALNMAALLMVPVVS
                     IVYIYYLIIVAHEIKEIVIFASLALLFINILIFYLYHSLLKFYSARMNEQVFKQMLEVY
                     SYQLDIARESEERVKALRHDIKHHIIELSAMAKKNNNDDMIKYLSGMKDFMLNPKEYST
                     TGNQEIDGVLNYTLQKANKTLNQVDVQINIPEDLYFNNFNICVILGNLVDNAVREASKS
                     KEKLLTIKMQIKQEVLLIFIENSYSGKILEKRNGLQTTQPELAIHGIGLENVKKVVIAN
                     GGEIKIDYTSNRFCVQVLLYMSRIKN"
     CDS             10001..10150
                     /gene_functions="biosynthetic (rule-based-clusters)
                     cyclic-lactone-autoinducer: TIGR04223"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg233_10"
                     /sec_met_domain="TIGR04223 (E-value: 2.8e-12, bitscore:
                     36.8, seeds: 127, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDKRTSTNGNKVLGYIAKRIAVRDANTTCPFLGYQPKLPTAVKKL
                     KNSK"
     CDS             10166..10549
                     /locus_tag="ctg233_11"
                     /transl_table=11
                     /translation="MLNKKIKRTLCGLVASLCLVGSTVPVFAETVDFDVTVPGDILSPR
                     AAKFDSEQRFYVTGTLFNKTGRLDCRSINRTNSAIQSRIASISPSYLSSSALYYSNAPS
                     GQTYYMTTSASVSYLRVKGRYTP"
     CDS             10633..11739
                     /locus_tag="ctg233_12"
                     /transl_table=11
                     /translation="MLKKIRWFCLTLCICSVLAGCNKSSVDVKEKAGEEIVSMEEAEYS
                     FPEKYEKTSDSGKVKFNCELEVPENIKGQAISTVDVKGLYSCDREKAWTIFGEGKEIIE
                     KSEIPVNEGRAPEDYYLFANDECLDINEGITYGSSNSKYYSSIGARNSNNQVVFEESDV
                     SFKSGEECITELQKIIDELGYHSEDFIFACYPLNSQTMKNLEEQYLQEGRLTEEKRKES
                     WSQEDDAYFIYGYQKYEDIPIFHEMMSIARSMAYDTPDNAPVQAIYSTRGIEILDIGGV
                     YEFEKGEQQVLLKPFEDIAAVVEEKFENILNDAEYEVTRAKFYERVYLDEGQKYKADPI
                     WYFEVVENNISKSVTLINAETGKEIFLQ"
     CDS             11762..12067
                     /locus_tag="ctg233_13"
                     /transl_table=11
                     /translation="MNRSTIPYSIVEERRRLNKCIENAPNECEREIYKKIRDMKIPYDK
                     LDTILETSKELIKKKEKQRKKRMLFLINVSGFAAGICVFIFFCGKRAVYKRRETDE"
     CDS             12060..12827
                     /locus_tag="ctg233_14"
                     /transl_table=11
                     /translation="MNRAHYLKTDIRRLIKNYPIYLAIVGVAVSMWFSLEDYAFTEGMV
                     NGNALDTYGFAVSMSGIMIAYAFCAFSYATVFCEDLEYKYARYSINRGNTWKYVVSKAV
                     VVYGASVITMVLGSLLFVASIRLKIPWTSEGLQDAFFMEGMYGSLIVGKHYWPYVFLSA
                     LQMGMFAGTLSLAASFLSMFVSNKMLILITPILIQQILLEYRGKGWFSVMLIYPTLNRF
                     STDIQYFLTVFGCSLCFSALLTWGIYKKIKSRL"
     CDS             12838..13698
                     /locus_tag="ctg233_15"
                     /transl_table=11
                     /translation="MKLLQYTWKNSMMKIANSKMAVFVILMIVVSRSYVGAIRQFSVAV
                     DYPSSWCVFPFAMCSFSYLIMFWFGVIYANSDVPFMQHVNMYHAIRVGRKCWALGQIGG
                     IFIRSVVLTVVAVICTILPLLPDIEWSNEWGKLLRTAATTRALTQFDSSVFIYYEIFSE
                     FSPLQLIGLEILLCACICTFIGVLMFLLSLFLNKIAAVAGGLALAIALFPVLNIHPMIR
                     HKLAFFIPTIWAELARIATPDYGYYWLPSIPYMFGFLIAGILCMTVIILIKVKKIEFNW
                     ENEDI"
     CDS             13714..14400
                     /gene_functions="transport (smcogs) SMCOG1000:ABC
                     transporter ATP-binding protein (Score: 170; E-value:
                     1.1e-51)"
                     /gene_kind="transport"
                     /locus_tag="ctg233_16"
                     /transl_table=11
                     /translation="MDRQDYVIEVSHVSKSFKDNKVLKDVSLLCESGKIYGLVGHNGSG
                     KTVLFKSICGFLSCDEGTITVNGKVMGKDKDMLTDAGIIIEDPGFLRTWSGYHNLEFLY
                     TLRNKKNKDYLCSVLRKVGLDPALKRPVGKYSLGMRQRLALAQAIMEDPGILILDEPMN
                     GLDKNGVREIRELLLKMKEENKLIILASHNREDIEVLCDEVYEMEGGVISKANVSSLHV
                     EGRYTP"
     CDS             14421..15458
                     /locus_tag="ctg233_17"
                     /transl_table=11
                     /translation="MRKDIMISAICALPLIMLTQNAYAQTYEKESESGKVRFQCELEVP
                     ENWNGKEIPKFILESVHFVDSEKTYANFVEGKEILEHYNTPASDLYPEENYYVLADGTN
                     VGIGMEFGVSTEKSAYYAQIGVTNTENMEKFTSATESIVNDQDAVQKVKETLENAGYAV
                     ENLVFQTSSLSADILREIENQYVAEGLLEESKRKPEWTNEDDVCIVYARQTVSGIPVYP
                     ELSVMAQALAYDTPESSPVVAVCSTRGIESLRVYGLYDFQEDGENVPLKGFDEIAATVE
                     TKYENLLDESTYTVTRAKFYERAYINEDQQYTAEPIWYLEINDNNSQKYVMLVNAETGK
                     EIYLM"
     CDS             15502..16074
                     /gene_functions="biosynthetic (rule-based-clusters)
                     cyclic-lactone-autoinducer: AgrB"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg233_18"
                     /sec_met_domain="AgrB (E-value: 1.1e-34, bitscore: 109.7,
                     seeds: 181, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIGEWSRKISNQICENQNEKEIIQYGLNQLFWILLNFFAIAISGV
                     LWHEFCFSILVFLEIYFLRPYAGGYHADTEIKCCMISVGIVNIAMLVRKINVISLDCMF
                     VIYLCFICVIVLFSPVDNPIHPLSKVDSRFYAKRSRQLIFWYSFLLVISIALRIMVLRD
                     SIIYTVLIVGISALAGKWKYRKRVFVL"
ORIGIN
        1 attttccaga cagaacaaag actgggcgga gcatatcgaa gtcccggaaa atgtcagccg
       61 gggtagaaat ctaaacctgg attatgtgat cgaaagccac ccggcagttt tagatgggtt
      121 tatcgacatg gcaagagctg agatccggat gcagaggata gaacaggcga taggagaaaa
      181 cgaagtgaca atcacggcag agacaagagg atatgaagca gaaggacata acgggacatg
      241 gcatacggtt gatgaaaagg aatatgcggg ggagaagttc ttcttaatgg aacatgatga
      301 atttggctcc gatgtggcag ggattatcgt agcagaaaat ggacagcttg tagcggagga
      361 tttatggaat gggtttgatg caggagcgtt agaagctgta tcagaatatt tgcaggaaaa
      421 tggaacaaca ctttatgact tgacggaatt cccgaaagat tctgttgtaa ccctgcggag
      481 tggacagaca cttacaatcg aagaaataca ggcagtacag aaagatacct gggaagaaac
      541 gatggcagga aaaaatgaat ctggaacgga tgtccggttt aatttccatg cagtcattga
      601 ggtgcagctg ccagaaggca taaagttgaa aatgccagag attcattacg ttgataattt
      661 ttatgtgatg gaagatgtaa atgcagaggg tgtagtaaaa gtaaaccggt atgaatcact
      721 ggatgaagcg atgcaggaat atttacgcct gccaaatcat caggaaaaag tgcttggtat
      781 ccagaatacg gaaacaatgc aggaaagcat ggattttatc cgatgtgaaa acggaataga
      841 tcagctgacc catgcatatg aacagatcgg agggtggctg aatccggaaa tatatgaagc
      901 ggtaaataaa atggaaaata tgctggactg gaatgaggta cagattgcat atcagattgg
      961 aaaacaatac tttacaatcc agactgctga agatggctat gattatacat tttacaatga
     1021 agattatcag gaggatgatg gaggaatcta tgacaatccg acaatttatg tagatgaagc
     1081 tgccagtgat attttggaag ataaagggta ctcattggaa gacgcaaaag tagtggatta
     1141 tgaagaactg atggcagatg tggaagaagt tcaggaagaa cagatgcagc ggatacaatt
     1201 agaaaaaaac tgcccagcaa gtatttttga aggatttcgc agggaagaag caatgcaaac
     1261 ctatgaagga atcgcaatgc agtttatcag gagtaaaggg tatctgacca tacaggcaac
     1321 agaagaagga tattcgttta ttttttatga ttctgatctg catgaaatcc agagtggtga
     1381 ttacgataat ccagacgcat ccattcagga agctgcttat gaaatcctta aaagtgaaag
     1441 aatggatgac ctggaatgtg tcaaagtgga ttataaagaa tttgaagaaa tgacgatcca
     1501 gcactctaag gatttattgc aggaggggga acttcgtgcg acttctgaga ttggaagaaa
     1561 tgaacgggca ttaaatagcc tgagcagggc agaagttgaa agaggtgtcc tgtatcatgc
     1621 acaggcagta ttagaagata tgggaatgga acaggaggta gagctgcttg ctgcaagagt
     1681 gtatggttcc agaagcagac aagacctcta ccgggaagat tctgaccttg atgtggttct
     1741 ttcctataaa ggtgatattc gagaagatag ctttttcaat gccttaaatg aatctggtat
     1801 agcgatggca ggaattaagg tggatattaa cccgattgca gaggagcgaa tcactctggc
     1861 agagtatata aaagaatccg aaaaatatct tgaccagcag gagattaaaa agctcgctgt
     1921 ggacctggat aattttagct atgacgttga tacctatgag tataacgata cagttgaaaa
     1981 tagagaagaa caggtggaaa aactcacgga ggatattttg aataagaaaa cagaaactat
     2041 caaggactgg ctgcttgagg tatccgagga atccgatata gacagcgatg ttataactgc
     2101 ccgttcttta ctttcccgtc tggaagatac agagcgattt tctatttttg acaaacagcc
     2161 ggagcaggaa cagccagaag ctacgatcag tttttatgtc gcagagtgca tggagtttcc
     2221 ggtcatggga gagtaccata acaacctcac tttagaagaa gccattaaaa tatatgagag
     2281 tatcccagca gagagactgc atgggattaa aggaattgga tttgatctgc aagatggtga
     2341 tgaagattat tccggggaat atgagttgat gagtgcagac cggatacggc gtgatctgat
     2401 agatatgatt ccacactata aagaaagccc tctggtgcag aaagcaatcg cagacatgga
     2461 aaagtatctg gatgaaaagc atggaagggt gcagaaaaca gaacatacgg cagaaacagt
     2521 aataggaagt ggacagaagc cttttgcggt tgcggcagac agaagggcag agcaggaact
     2581 ggtatctgta agtcagagcc agtcacaaaa ggcagaacct gcaagcagag aaaaaggtga
     2641 agtgaagaag tctgtgctgc agtctttaaa agattttcag gcaagggcaa aagcacagga
     2701 acagaataaa acaacggaga aatccaagac acataagaag ggagaggtgg aattatgatg
     2761 gatctggcga tgaactttga tgcggatgaa tgtttagtaa ccgcaatgtt tgataaagga
     2821 aacagaaatg acacgatgga ggcaatcgac catatcattc cttttctgaa aggcgatgca
     2881 gatatgatcg ggcttgtctg caataccata agaaaactgt tctgtatgag cgatgaagga
     2941 tatgaagttt ttcttatgga tctggaagaa tataaaatgg aactggaaga ggaggacgaa
     3001 gaatgagtac aagtcagtgt gcagtatatc aggtaaaaga taccccagag taccgggatg
     3061 tccgtttccg ttcttacgag aaactgaaaa gcgaaggaag aacagtccag atagaaaact
     3121 atcagcaggt gtacattgga agaatccagc cgggggaaac tccggctgat attaaactcc
     3181 gtttacagaa gcaacgaccg aagaacttca aaggtcattc catcggttgc agcgatgtga
     3241 tcatcattac cgatgatgga aaaaccacag cttactatgt caacaaagat ggttttatca
     3301 tcattccgga atttctcaca atcaaaagtt cttccgatac cagactttcc attgatacga
     3361 ccggatatga aatcgaagga aagaaaggaa catggcttgc ccaggattat atcctaatga
     3421 atgagaagaa atggtttctg atggaacatg aggagtatgg gacaagagca gcctatgtga
     3481 ttctcagtga agaaggtacc gtagttatga atgactgtta caacggcttt gatgaagaag
     3541 ccagacggaa cattcagaat ttcatgcagc aacaggcaga gcaggcacag caaaaacaac
     3601 aggaaatgca ggcacaagcc cagaccggac agacacaatc tggagaaaca caaaagaaga
     3661 aaccagagct ggcaaactgg cagaaggtta tggataatgg agaatatctt cgcaatgcag
     3721 agatggcaga agaagccaac tataatatga ttgacggact gatgaacaac actccaaaga
     3781 aaaaagataa gaacgctcca cggagatcgg tactgaaacg gctccgtaat catcagaaga
     3841 agatagccag tcaaggcaaa ggacagccac agcaacagaa ggcgatggaa gaagagatgg
     3901 aaagaaagaa gaagtaaaaa aattttgccg gaatttttga tgataaaata aaaaaatggt
     3961 tgattttttc tctcaaatat catatcataa tattaacagg actccccgca cctctcacgc
     4021 aagtgatgtg tcccatgggg agacatttta tttttggaga aataatggtg aatacaagtg
     4081 aaactaaaaa tgaaaagttg aaaaataatg aagcaactgt acaggtaatg aaaaaaccga
     4141 aaacctttgc tcaacaagtt gaaattatta aagaaaaggg ttttattata gataatgata
     4201 cagaatgtat cggattttta aaacaggcga attattatag attatctgct tatttccttc
     4261 cgtttaggaa aaaggatggg acgtattttt caaatataaa ctttcacaga attcaaagaa
     4321 tctatgaatt tgacagtaga ttgcgtggtg tattatttaa ttatatagaa aaagttgaat
     4381 tatacttaag aacgcaatta gcttattaca gtggacatgt tcatggggct ttaggatata
     4441 tggatgtggt tatttacaat gataggcaca atcatgaaaa gttcgtgaaa ctgttaaatg
     4501 tatgtataga ggaaaataaa agtacatcag tagttcagca tcataaagaa aagtatggtg
     4561 gaaattttcc tatatgggtt attgttgaat ttttttcaat gggaatgctg tcttactttt
     4621 atgcagattt acagtctggt gaccagaaat atttagcaaa agaattatat ggtacatcag
     4681 tggcctgttt aaaaagctgg ttacgctgta tcacggattt gagaaaccgc tgcgcacatt
     4741 attcaaggct gtattattgg tcatttcccg cattacccaa aatgccaagg gaattagaaa
     4801 catcaccaaa cagaaaattg ttttcacaaa tacttgtatt aaaattatta tatccagaca
     4861 aaaaagaatg gctcaacaaa gtcttgatag aattaaaagc tattgtagaa gaatatgaga
     4921 atgatatatc attgagacat atagggtttc cagaagattg gtatgagcag ttagaaaaat
     4981 agagacatat tataagggac agaggagtaa tctgtccctt tttaatatga actataaatt
     5041 tggctctttt ctatcctgta gttgctgctt gcaattcttt ccaagaatca tgtcaatatt
     5101 cgcagccaca gtgcgaagct cccgttcata atcccggtgg ctagaaaaaa cttcccgttg
     5161 cttatccctc aattcgataa gccggtcctt ttcggcatag agggctttca tagaaggtaa
     5221 tttattcccg ccagattttg ctttgagtgt tcggagggct gtgtcataca gggaaagttc
     5281 agcccggtgt tcttcagaaa atttctgttt gtttcggctt ttacgataat cggcgtacac
     5341 atttttatat gccagatatt gtccggtaaa atgaatctgc tcattcacat ctttaagttg
     5401 ctgttcagta tcttttaaag attttctgga agcactggtc tggtatgaag cctgatcgag
     5461 tgctgcatgg aaatcatcaa gagaatcata gccatgttcc tgtatgtagg caacagtctg
     5521 agccatctgc ttcaaattgg tgagctttac tttttgagca taggcttcgc tctgctgtgc
     5581 tttaatacag gtttgcagat ctatgacaag acggaggtct gattttatga aaatgaacgg
     5641 tgctggtata gcagaagtat cggagaaagg aacggttggt aaatctgtgg aagtattcgg
     5701 agactgctgt tccagaattt cttctttctg ttctttatgg gattttgtgt tttcctcaaa
     5761 tgctttcaag agaaaatctt ctgtgtatct ggttccaaga ttccttccag tgatatattt
     5821 ttttctgcca ggatgaagat agctgtagcg gtttcgactg atcttgaaga tgatgtgata
     5881 tttttcatca aggatttttg aaaattcctc tggtgatctg gcggtacttg cagcatcatc
     5941 aatagcgtca cgcagaaatt gtttctctgt ctggtaacga gtttctttcg gtgtgattcc
     6001 atcttctttc atttcctgat tcagcttatc taatttttcc tgtccccggc gttgtgccca
     6061 gtattctttt tcggtgattt ttctttcagc aggagtgagc agatcaactt ggtgcagccc
     6121 ttctttttgg cacatatcca tgacttcctg ttttaaatgg gtaaggtatg ctgtgcttag
     6181 atggtgcttg tatccggctt ttgcttcaca gtcaaattcc atatagggtt cttgtggtat
     6241 gtcatattta cggagactgt tgattacgat gtgtacatgg atgtttccac tttcattatg
     6301 accgtcggta tgagtacaga ctaaagcctg atgaccggga aagtttttct ttgcaaaagt
     6361 taatccgagt tgctgggcac gttcaccggt caatccacat tcatccttgt cttttggggc
     6421 gaagctgatg atatagtgat gggattttat ttcattgaag tttttgttct tgtgatagta
     6481 gctgttcagt tcctgacatt cagatgcaaa agagaatgga tcacagttca gactgtccag
     6541 ataatattct tctctcagta tcatatgccc ttcttcatca agaatcggtt tttgtgtata
     6601 ctcgttgtgc tggaagataa gataccgttc cgattctcca tagtcagagt ttttgtttgc
     6661 gatatgttta attactgcca cgaaaatcac ctgccatttt catcacttta tatttcattt
     6721 cataaatatc ccggagagac tttcggattt catttctcat ttcagaagag aggattccac
     6781 cctgattaaa atatcggaca atctgattta ggttgctgcc aattttacca aactcgctaa
     6841 taagtttttt tatttcggga acatctgcgg taatttcgta tttgatgatg actttctggt
     6901 tgtccagggc acttcggaca aaatcagaaa ccgtcatgct gttagccttg gctctttctg
     6961 caagaagatc atattcagtt tcattcatgc gtaaatgcac atctttagtt tttgcaagag
     7021 tttcctcttt cttaggtctt gtcattgata acttcctttc ttacgtggta gtggcttcat
     7081 aagaaaatcc aaatttcgca gcctgctggg aaagtaagga atgaaaaatt atcgcactgt
     7141 gaccatgtaa atggaaacca atacacatat ctgtgattgt ggtcgagggt atggggaaac
     7201 gaaatcccca tcaagttgca agtggtcaat agcccggaaa gggttattga ccacttgctc
     7261 tatagtgttg aaaaattgct gcttataaat atatataaac cagaaaaaat aggtgagcaa
     7321 gattaaaata aagttaattc ttgttcacct attggataat agaatttaat tccttgttat
     7381 tcgctttaaa acggatgaaa gtaataataa atcttcttca gaaaatttac taatatctga
     7441 aataatagaa tgtaacaaag tagggttctg aaaagatgga tcaaaaaatt cagtaggagt
     7501 aatatcgaag tacttacaaa tatctaaaaa agtattcata gagggtaata ttctgccaga
     7561 actaattgat tgtatatatc cttgcgaacg accgattgct aagctcaaag tgtattcgga
     7621 gattcctttt tgacaacgta attcagtaat tctatttttg ataaatgctg aaaaatcagt
     7681 ttcctcattc attcatgaca cctcctatac atattgtaag tgttttaaaa taattttatt
     7741 cgattttaaa tatctatttg acaattattt tgatgaaaaa tatactataa atatctaaaa
     7801 acggttttga gtgaagattt aaaaggagat gacttgcatg agtaataccg agagagtatt
     7861 atacttcccg gagggaaaaa tcatgaagac tataatttgc gatgatgaaa aaagcacatg
     7921 ttccgagcta gaagagatta tactgaaata tgcgaaagag aagagcgttt cacttgtgac
     7981 agaagttttt tattctggag atactttgtt ggattatttg aaaagagaga aaataaacat
     8041 tctttttctg gatatagaat tgccagggaa agatggagtt atggtaggca aatatataag
     8101 agaggttctt gaagaagaga atatattttt gatatatata tcttcaaagg aaaattatgc
     8161 attacagctt tttcaaaatc gcccgtttga ttttttggta aagcccatag aagcggcgaa
     8221 gatatatcat gttttggata atatttatcg tatatcggga aaaaatagtg tgggatttga
     8281 gttccaaact caaaatagta catatcgcat ttcgtataaa gatattttgt attttcaaag
     8341 tactggaaga aaaattaata ttgtaatgaa aaaagagatc agaacatttt atggaaaatt
     8401 gaatgagatt gaaaaacgga ttccagaaaa tgttttttta agaatacata aatcgtattt
     8461 agtaaataaa aattatgtaa aggaatttac atacgagtgg gtaaaaatgc tgaatggaga
     8521 tgtactaaat ataagtaaaa ttaatcgtgc agatgtacga agaaagattt tggagagtgc
     8581 tgcagatgag tttaaaaata tttaatgata ttatagtgtt actggcaaat gcattacgtt
     8641 tttacgcatt gaagcatttt gttggtattt ttgtgcaaaa agaagagagt agatggaagc
     8701 atgtctctat tttatatatt ataggctggg catggacaag tgcgataagc ttgctatttt
     8761 cctctccggc tatgaatatt ttgtcaaaca ttacaagtct ttttttgatt ttttttccat
     8821 accgcataaa gaaaacaaag aaatgtttgg ctgtatttgt tatatatgtg attaatgcat
     8881 tggttgacag cattgtcatt ttatctttaa caaaatatac gatgggacag ccggtgaatc
     8941 aggtatgtga atgtattacc agctttgctt tattatttat tgcaattatt atccagagga
     9001 caacagaacc cgaaaaagaa attacattac cggcattaaa tatggctgca cttttaatgg
     9061 ttcctgttgt cagtattgta tatatatatt atctgattat tgttgcgcat gaaataaaag
     9121 aaattgttat ttttgcatca ctggcacttc tttttattaa tattctcatt ttttatctgt
     9181 atcattcact ccttaaattt tattctgccc gtatgaatga gcaggtgttt aaacagatgt
     9241 tagaagttta ttcttatcaa ttagatatag ccagagaatc ggaagaacgg gtgaaagcat
     9301 tgaggcatga tataaaacat catatcattg agttgtctgc aatggctaaa aaaaataata
     9361 atgacgacat gataaaatat ttaagcggca tgaaggattt tatgctaaat ccaaaagaat
     9421 attcaactac aggtaatcag gaaatagacg gagtattaaa ttatacgctg cagaaagcaa
     9481 acaagacgct gaatcaagta gatgttcaaa taaatattcc ggaagatcta tattttaata
     9541 attttaatat ttgcgtgatt ttggggaatc tggtagataa tgcagtaaga gaggccagta
     9601 aatcgaagga aaagttacta actataaaaa tgcaaataaa acaagaggtg ttattaatct
     9661 ttatagaaaa cagctattca ggaaaaatcc ttgaaaagag aaatggactg cagacaactc
     9721 agccagaact tgcaatacat ggtattggat tagaaaatgt aaaaaaagtg gtcattgcca
     9781 atggaggaga aataaaaata gattatacat ctaatagatt ctgtgttcag gtccttttat
     9841 atatgtcgcg gattaaaaac taagagactc gttaggggtc tcttttttac ttgaaagaaa
     9901 agtctaattt tgacaaaatc gtgggcgaat tttgacaatt gaataaataa tcaataatta
     9961 tatgctacaa ttcaatcact tcaaagggag gtgcaagcca atggataaga gaacttctac
    10021 aaatgggaac aaggtattgg ggtacatagc aaagaggata gctgtaagag atgccaatac
    10081 aacctgtcct ttcttaggat accagcctaa actcccaacg gccgtaaaaa aattaaagaa
    10141 ttcaaaatga aaggagattc aaattatgtt gaacaaaaag attaaaagaa cattgtgtgg
    10201 tttagttgct tctttatgtt tggtaggcag tacagttccg gtatttgctg aaacagttga
    10261 ttttgacgtc acggtaccag gagatatcct ttctccgaga gctgctaaat ttgattcgga
    10321 acagaggttt tatgtaacag gaactttgtt taataagacg ggaagattgg attgcaggtc
    10381 tattaatcgt acgaatagtg caatacagtc aaggatagcg tcaatttctc cgagttattt
    10441 gtcgagtagc gcactatatt acagtaatgc accatcaggg cagacgtatt acatgacaac
    10501 atctgccagt gtatcatatc ttcgagtgaa gggacgatat actccgtaat atttacgaat
    10561 aacatttaaa ataacaagtt cagttagggg atacacatac ggtatccctt agctgaattt
    10621 aaggagaaaa atatgctgaa aaaaataaga tggttttgcc tgacattatg tatatgttcg
    10681 gttttggctg gatgtaacaa gagttctgta gatgtcaaag aaaaagcagg ggaagaaata
    10741 gtctcaatgg aagaagcaga atatagtttc ccggaaaagt atgaaaaaac ctctgattcg
    10801 gggaaggtaa aatttaattg tgagttggaa gtgccggaaa atataaaagg acaagctata
    10861 agcacagttg atgtaaaggg actatatagc tgtgacaggg aaaaagcatg gactatattc
    10921 ggtgaaggaa aagaaataat tgaaaaatcg gaaattccgg taaatgaagg gagggcacca
    10981 gaagactatt atctatttgc aaatgatgaa tgtcttgata taaatgaagg cattacttac
    11041 ggaagcagca attccaaata ttattcatcc atcggtgcgc gaaattcaaa taatcaggtt
    11101 gtgtttgaag agtcagatgt ttcctttaaa agcggcgaag aatgtattac agaattacaa
    11161 aaaataatag atgaattggg ataccattca gaagacttta tatttgcttg ttacccctta
    11221 aattctcaga caatgaaaaa tttggaagaa caatatttac aggaaggtcg tttaacagaa
    11281 gaaaaaagaa aggaaagctg gagtcaggaa gatgatgcgt attttattta tgggtatcaa
    11341 aaatatgaag acattcctat ttttcatgaa atgatgagta ttgccagaag catggcatat
    11401 gatactccgg ataatgctcc tgtccaggcg atatattcta cccggggaat tgaaattctg
    11461 gatattggcg gcgtttatga atttgaaaag ggagaacaac aagttttact gaagcctttc
    11521 gaggatattg ctgctgtggt tgaggaaaaa tttgagaata ttttaaacga tgcggagtat
    11581 gaagtgacga gagcaaaatt ctatgagagg gtatatctgg atgagggaca aaaatataag
    11641 gcagatccta tctggtattt tgaagtagtc gaaaataata taagtaaatc tgtaacatta
    11701 attaatgcgg aaacaggaaa ggaaatattc ttgcaataaa aattagcgaa agggatgttt
    11761 tatgaataga tccacaattc cttattcgat tgtagaagaa cgaagaaggc ttaataaatg
    11821 tatagaaaat gccccgaatg agtgtgaaag agaaatatat aaaaaaatca gagacatgaa
    11881 gataccttat gacaaattgg atacaattct cgaaacaagc aaagagctga ttaaaaagaa
    11941 agagaaacaa agaaaaaaaa ggatgttatt cctgataaat gtaagtggct ttgctgcagg
    12001 tatttgtgta tttatttttt tctgtggaaa aagagctgtt tacaaaagga gagaaacgga
    12061 tgaatagagc acattattta aaaacggata tccgtcgtct gataaaaaat tacccaatat
    12121 atttggccat tgtgggtgtt gcagtatcca tgtggttttc ccttgaagat tatgcgttta
    12181 ctgagggaat ggtaaatgga aatgcgctag atacatacgg tttcgctgtt agtatgtccg
    12241 ggattatgat tgcctatgct ttttgcgcat tctcttatgc aacggtgttt tgcgaggatt
    12301 tggagtataa atatgccaga tacagcatca acagaggaaa tacatggaaa tatgtggtat
    12361 ccaaggcagt ggttgtctat ggagcgtctg tgatcactat ggttttggga agccttctgt
    12421 ttgttgcgtc tatacggtta aagataccct ggacttccga gggattacag gatgcttttt
    12481 ttatggaagg aatgtacggt tccctgattg tcggaaaaca ctactggcct tatgtttttt
    12541 tgtccgcatt gcaaatgggg atgtttgcag ggaccttgtc attggcggct tcatttctgt
    12601 ctatgtttgt ttctaataaa atgctgatat tgatcacacc tattttaata cagcaaatat
    12661 tattggaata tcgtggaaag ggctggttca gcgtaatgct gatatatccg accttgaatc
    12721 ggttttcgac ggacatacag tactttctta cagtctttgg ctgtagcttg tgtttttcgg
    12781 cactgcttac ctggggaata tacaaaaaaa taaaaagcag attatagagg tgggagtatg
    12841 aagttattac agtatacctg gaaaaattcc atgatgaaaa tcgccaatag caaaatggca
    12901 gtttttgtaa tattgatgat tgtagtcagc cggtcatatg taggggctat ccgacagttt
    12961 tcagttgcag tggactaccc gtcctcttgg tgcgtatttc catttgcgat gtgtagtttt
    13021 tcttatctga ttatgttttg gtttggagta atttatgcga actcggatgt gccttttatg
    13081 cagcatgtga atatgtatca tgcaatccgt gtaggaagaa agtgttgggc attagggcaa
    13141 ataggaggga tttttatccg ttccgttgtt cttactgttg tggcagtcat ctgcacaata
    13201 ctcccgcttt taccggacat tgaatggagc aatgaatggg gaaagctgct gagaacggca
    13261 gcaacgacaa gggctcttac gcagtttgat agttctgtgt ttatttatta cgagattttc
    13321 tctgaatttt cgccattaca gcttataggg ctggagattc ttctttgtgc ctgtatctgt
    13381 acatttattg gggttctgat gttcctgcta agtttgtttt tgaataagat tgctgcagtt
    13441 gcaggtggtc ttgccctggc aatcgctcta tttcccgtgc tgaatataca tcccatgata
    13501 cgtcataaac tggctttttt tatcccgacg atatgggctg aactggcaag gattgcaacc
    13561 ccggattatg gttactattg gctgccatct ataccttata tgtttggatt tttaatagca
    13621 gggattttgt gtatgacggt cattatttta ataaaggtaa aaaaaataga atttaactgg
    13681 gaaaatgagg atatatagcg aggagtgaaa tatatggaca ggcaggatta cgtaattgaa
    13741 gtatctcatg taagtaaaag cttcaaagat aacaaagttt taaaggatgt ttcactttta
    13801 tgtgaaagtg gcaaaattta tggtcttgta gggcacaacg gttctggaaa gactgttttg
    13861 tttaagtcta tttgcggttt tctctcctgt gatgagggaa cgataactgt caatggtaaa
    13921 gtgatgggga aagataagga tatgctgacc gatgcgggga tcattattga ggatccgggt
    13981 tttttgcgga cctggagtgg ctatcataat ctggaatttc tttatacttt gcgaaacaaa
    14041 aagaataaag attatctctg ctctgttctg agaaaggttg gtttggatcc tgcattgaag
    14101 cgtccggttg gaaaatattc actgggtatg cggcagagac ttgctcttgc acaggccatc
    14161 atggaagatc cgggaatttt gattctggat gaacctatga atggtctgga caaaaacggg
    14221 gtaagagaga tcagggagct tctgttaaaa atgaaagaag aaaataaact gattattctg
    14281 gccagtcata atcgggagga tatagaggtt ctttgcgatg aggtatatga gatggaggga
    14341 ggggtaatca gtaaagcaaa tgtaagcagt ttacatgtag aaggacgtta tacaccgtga
    14401 tttgtaagtg ggagcggaaa atgagaaaag acataatgat ttcagctata tgtgcgttac
    14461 cgcttattat gctgactcaa aatgcgtatg cgcagacgta tgaaaaggaa tccgaatccg
    14521 gtaaagttag gtttcagtgt gagttagaag ttccggagaa ttggaacgga aaagagattc
    14581 ccaaatttat tttggaaagt gtgcattttg tggatagtga aaagacatat gcaaattttg
    14641 tagaaggaaa agaaattctc gagcattata atactcctgc tagtgatcta tatccggaag
    14701 aaaactatta tgttttagcg gatggtacaa atgtagggat tggaatggag tttggagtat
    14761 caacggaaaa atcggcttat tatgctcaaa taggggtgac taatacggag aatatggaga
    14821 agtttacttc tgcgacagaa tctattgtaa acgatcagga tgctgtacaa aaagtaaaag
    14881 aaactcttga aaatgccgga tatgcagtag aaaatttagt ttttcagact tcttctttga
    14941 gcgcggatat acttcgggaa attgaaaacc aatatgttgc tgaaggattg ctggaagaga
    15001 gtaaacgaaa gcctgagtgg acaaacgagg atgatgtatg tatcgtatat gcaaggcaga
    15061 cagtaagtgg gattcctgtg tatcctgaat tatcggttat ggcacaggcg cttgcatatg
    15121 atacgccaga gtccagtcca gtggttgctg tttgttctac acgggggata gaaagcctgc
    15181 gtgtgtatgg tctttatgat ttccaggaag atggggaaaa tgtaccgtta aaaggttttg
    15241 acgaaatcgc agcaacggta gaaacaaagt atgaaaactt attggatgaa tctacttata
    15301 cagtgactcg ggcaaaattt tatgagcgtg catacataaa tgaagatcag caatatacgg
    15361 cagaaccaat ctggtatttg gagataaatg ataataattc tcaaaaatac gtcatgctgg
    15421 ttaatgctga aacaggtaaa gagatatatt taatgtaggg ttaatatgat taaagagaga
    15481 gattctgtag gagaaaattg aatgataggt gagtggagca ggaaaatatc aaaccaaata
    15541 tgtgaaaatc agaacgaaaa ggaaattatt caatatggtt taaatcagct tttttggata
    15601 ctattaaatt tttttgcaat tgcaatatca ggtgttttgt ggcacgaatt ttgttttagt
    15661 atcttggtct ttttggaaat atattttttg cgcccgtatg cgggcggtta tcatgctgat
    15721 acagaaataa aatgctgtat gatttctgta ggaatcgtga atattgcaat gctagtaaga
    15781 aaaatcaacg tgatttcgtt ggattgtatg tttgttattt atttatgctt catttgtgta
    15841 attgttctgt tttctcctgt agataatccg atacatccat tgtcaaaagt cgatagtagg
    15901 ttctatgcaa aaagatcgag gcaattaatt ttttggtaca gcttcttgct tgtaataagt
    15961 atagctctgc gaattatggt tttaagagat tcaattatat acacagtttt gatagtagga
    16021 atatctgcat tggcaggaaa atggaagtac aggaagcgag tattcgtttt gtgaaaaata
    16081 taaattaaaa acgtccagta ggtttgatat gctaccctca tataggacaa tgaaatataa
    16141 aagtcctata tgggggt
//
