LOCUS       c00049_gnlPro..        15729 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|NNJPFCCJ_77.
ACCESSION   c00049_gnlPro..
VERSION     c00049_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-06 03:57:51
            Original ID  :: gnl|Prokka|NNJPFCCJ_77
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 23194
            Orig. end    :: 38923
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..15729
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[33194:38517]"
                     /cutoff="10000"
                     /detection_rule="(minimum(4, [AcetylCoA_hyd_C,
                     AcetylCoA_hydro, B12-binding, Biotin_lipoyl, Glyoxalase_4,
                     HMGL-like, MM_CoA_mutase, MeaB, OAD_beta, OAD_gamma,
                     PYC_OADA]) and minimum(1, [CT_Btheta, CT_Propionyl_CoA1,
                     CT_Propionyl_CoA2, CT_Propionyl_CoA3, CT_Vparvula]) and not
                     Cytidylate_kin)"
                     /neighbourhood="10000"
                     /product="succinate2propionate"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      10001..15323
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(minimum(4, [AcetylCoA_hyd_C,
                     AcetylCoA_hydro, B12-binding, Biotin_lipoyl, Glyoxalase_4,
                     HMGL-like, MM_CoA_mutase, MeaB, OAD_beta, OAD_gamma,
                     PYC_OADA]) and minimum(1, [CT_Btheta, CT_Propionyl_CoA1,
                     CT_Propionyl_CoA2, CT_Propionyl_CoA3, CT_Vparvula]) and not
                     Cytidylate_kin)"
                     /neighbourhood="10000"
                     /product="succinate2propionate"
                     /protocluster_number="1"
     cand_cluster    1..15729
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(minimum(4, [AcetylCoA_hyd_C,
                     AcetylCoA_hydro, B12-binding, Biotin_lipoyl, Glyoxalase_4,
                     HMGL-like, MM_CoA_mutase, MeaB, OAD_beta, OAD_gamma,
                     PYC_OADA]) and minimum(1, [CT_Btheta, CT_Propionyl_CoA1,
                     CT_Propionyl_CoA2, CT_Propionyl_CoA3, CT_Vparvula]) and not
                     Cytidylate_kin)"
                     /kind="single"
                     /product="succinate2propionate"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..15729
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="succinate2propionate"
                     /region_number="1"
                     /rules="(minimum(4, [AcetylCoA_hyd_C, AcetylCoA_hydro,
                     B12-binding, Biotin_lipoyl, Glyoxalase_4, HMGL-like,
                     MM_CoA_mutase, MeaB, OAD_beta, OAD_gamma, PYC_OADA]) and
                     minimum(1, [CT_Btheta, CT_Propionyl_CoA1,
                     CT_Propionyl_CoA2, CT_Propionyl_CoA3, CT_Vparvula]) and not
                     Cytidylate_kin)"
                     /tool="gutsmash"
     CDS             complement(101..274)
                     /locus_tag="ctg49_22"
                     /transl_table=11
                     /translation="MNAFATGHVLAAAKAFFCRNMLHFFIDVVIIKHDVNLLSLNRRFA
                     AFEDMDNTYLEV"
     CDS             complement(298..909)
                     /locus_tag="ctg49_23"
                     /transl_table=11
                     /translation="MKIAKKFMALALAAVLSVGCAFGVSADGSRTKDVTVVQEDSQVYE
                     IIQKIEDTDGFKELKEAVPAVADAFEKVGKGEMDMNGFADVLKTLAEEETDETLKAAIE
                     EVIEKLDGKDFVTGFIQFKVLDSVKAVKNADGKYEVEFSVPSITDDMENIQLVCYNEET
                     KEWTIVDPINVDKEKKTIKVALDDLCYFTIVADAKEDTAE"
     CDS             complement(1008..2039)
                     /locus_tag="ctg49_24"
                     /transl_table=11
                     /translation="MTKTTRKAIRQRKICMLLIIILIIVLSVLGGGYYLLSQKNAASPQ
                     NGGQNSDSRNQTDLSQNSDIVEYKGETYKYNDHLSNYLFLGIDTRETVDTYQSQVDAGQ
                     ADAIFLVSMDRATEKIKVLFIPRDSMTRIEVFNPAGKSLGMTTDHINIQYAYGDGRQKS
                     CELMKTAVSNLLNGLPVQGYCAMNMDGISVITDYVGGVEITVPDNSLEDINPDFKEGSV
                     VTLTGENAEQFVRYRDIGKSQSALVRQERQKTYLQAFLQKAQEQASKDAGFVTGLYDSI
                     DNYTVTNMGNDVFAKLLTASQNEITDSRTVPGEGTQGENFDEYHVDEDELTDMIISMFY
                     NKN"
     CDS             complement(2076..3050)
                     /locus_tag="ctg49_25"
                     /transl_table=11
                     /translation="MINDKGEFGKVSKIRKKKIKKTNILLGFICILLAVLLGFILVTSY
                     KSEQKESRHLSEIADDQQSGIEDYEAVKEHAKELEEISSEEAEDTEDIKSKNTEDTKDT
                     EKTDADKTEDTKDKTTAASGIVCWGDDLINGEESNTYSYMTVLQKLLTDNGYNMTVINK
                     TLQGGGTLSMMKMAGVSDETLQGYITRHQQAANGAQLNVTETGIRDLTEEQTTRNDMDC
                     IPVIFMGYYGGWNHDPAELADQQEQILNTFQNKDQFIVVGTRPMDGSVTSEALDQVLSQ
                     KWGEHYISLANVTAQPSSTYEAQQAMAEAILQKLQELNYISKN"
     CDS             complement(3084..3794)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) CbiA"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg49_26"
                     /sec_met_domain="CbiA (E-value: 1.3e-08, bitscore: 26.3,
                     seeds: 79, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKKLNLTDKRNPDYFYSEAIKTLRTNIQLSGQSIKTILVTSCYPN
                     EGKSDVVLSLARELGSIGKKVLLLDADIRKTAYAGRLGVEEEVKGLSQLLSGQVGLQEI
                     IYSTNFPNMDIIFGGPSAPNPSGLLSENIFKVFLKEIREYYNYILIDTPPIGTVIDAAV
                     IGRCCDGAVFLIEPGNVRYRDAQKAFKQLERSGCRILGAVMNKIDTSDDKYYSSYYKHY
                     GEYYRRSDEEAQIK"
     CDS             complement(3816..4595)
                     /locus_tag="ctg49_27"
                     /transl_table=11
                     /translation="MLDNLNSNFESSKAQRPDANDDEVEIDLLEIFYALKKKILLVLMV
                     ALVGGCIAAAYTQFLMTPIYSSTSSILVLSKETTLTSLADLQLGASLTSDYTVLITSTP
                     VMEQVISDLDLDMTAEQLKESVSINNPTDTRILEITVNNTDSKMAKKIVDEIANVSSSY
                     IGDKMEVIPPKIIEVGKIATVRTSPSVKKNAALGFLLGFLACAAIVVVYAVMDDTIKTE
                     EDIEKYLGVSVLAKVPDRKDFINAKNRKSKNKNKKHH"
     CDS             complement(4736..5482)
                     /locus_tag="ctg49_28"
                     /transl_table=11
                     /translation="MSIKGIYDIHCHIVPGVDDGATDIGETVKLLRMEYEQGVRTVITT
                     PHFRFRMFETPAEKVREQFRLVEKAASEISPDLHVYLGCEFHANMEMLPMLREQKVMTM
                     AGSRYVLTEFSHNSEESYIRERLGALLSGGYKPIIAHIERYEATRNSLDFVEELADMGV
                     YMQINADSITGKDGFFTKRYCNKIMKDGLLHFVGSDCHNSAKRSSRIGEAYRMVSAKFG
                     QDYADELFIHNPAEILKQKQKHEATD"
     CDS             complement(5630..6706)
                     /locus_tag="ctg49_29"
                     /transl_table=11
                     /translation="MSELSFEQMLEDSVKTIRNGEIVQGTVIDVKEDEIILNIGYKADG
                     IITKNEYSNDASLVLTDAVHVGDTMEAKVLKVNDGEGQVTLTYKRLAAEKGNKRLEEAF
                     ENQEVLKAPVTQVLDGGLCVNVDEARVFIPASLVSDTYEKDLSKYADQEIEFVITEFNP
                     RRRRIIGNRKQLLLAEKAEKQKELMERIHVGDTVEGTVKNVTDFGAFIDLGGADGLLHI
                     SEMSWGRVENPKKVFTVGDKVKVLIKEINGEKIALSLKFPEANPWLTAAEDFAVGNVVK
                     GKVARMTDFGAFVELAPGVDALLHVSQISREHVAKPADVLSIGQEIEAKVVDFNGEDKK
                     ISLSMKALEAPAEEATEE"
     CDS             complement(6687..7565)
                     /locus_tag="ctg49_30"
                     /transl_table=11
                     /translation="MKVKVAETAGFCFGVKRAVDKVYELIDTEQKPIFTLGPIIHNEGV
                     VADLEARGVHVITEADLDSPDDTLQNGTVVIRSHGVGKPIYDKLKEKNISYVDVTCPFV
                     LKIHRIVEKESLAGNHIIIIGDKDHPEVQGICGWCQGPYTVIGNKEEAEVFVSPKGKKI
                     SIVSQTTFNYNKFKDLVEILCKKRYDNNVLNILNILNTICNATEERQREAKNIAGEVDT
                     MLVVGGRHSSNTQKLFEICKKECGNTYYIQTPVDLDSEMFQCSSYVGITAGASTPNKII
                     EEVQEHVRIKF"
     CDS             complement(7584..8255)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Cytidylate_kin"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg49_31"
                     /sec_met_domain="Cytidylate_kin (E-value: 1.3e-77,
                     bitscore: 251.5, seeds: 12, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MGCNIAIDGPAGAGKSTIAKKVAKELSFIYVDTGAMYRAMALYLL
                     NHGVNGENQEEIEAVCSGADISIEYKNGEQIVILNGENVNAMIRTEQVGNMASKSSANP
                     KVRAHLLKLQRTLAEKNDVVMDGRDIGTTILPNAEVKIYLTASADTRAKRRALEYEQKG
                     EAFDLDQIRKDIIERDERDMNREISPLKQAEDAVLVDSSEMGIDDVVNAILNVYKEKVQ
                     K"
     CDS             complement(8441..9889)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) HI0933_like"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg49_32"
                     /sec_met_domain="HI0933_like (E-value: 3.9e-128, bitscore:
                     418.8, seeds: 46, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MLPVVHIYIDRSEAETWNHDEIDNLQGKINTGEYSMSKVIIIGGG
                     AAGMMAGVFAARNHHEVHILEKNEKLGKKVFITGKGRCNVTNACDTEELFPAMMSNPKF
                     LYSSFYSFTPQDVMEFFEKAGVPLKVERGNRVFPQSDHSSDIIRALERELKKAGAKIHL
                     HTAVQEIVKKPVTDSANTLESEAALTESGSDAGKGRKGKKSPDIPQEKITGVILTDGTF
                     MEGDAVIVATGGFSYQSTGSTGDGYRFARELGLKVTDIAPSLVPLKTKEDYVPKLQGLS
                     LKNTGLTIKNGKKVLYEDFGEMMFTHFGVTGPMILSASAHIGAKLAKAPNGELSAYLDL
                     KPALTREQLDARILREFEAGPNKQFKNVIGVLFPSSLTPVMLELGGIPAEKKIHDISRE
                     ERQHFIDLIKAFPFTITGMGEFKEAIITRGGVSVKEINPGTMESKKISGLYFAGEVLDL
                     DAVTGGYNLQIAWSTAYLAAQAIQ"
     CDS             complement(10001..11413)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: HMGL-like"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: PYC_OADA"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg49_33"
                     /sec_met_domain="HMGL-like (E-value: 1.3e-46, bitscore:
                     150.5, seeds: 15, tool: rule-based-clusters)"
                     /sec_met_domain="PYC_OADA (E-value: 1.5e-58, bitscore:
                     189.1, seeds: 434, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAELEKKPVKIVETILRDAHQSQIATRMTTEQMLPIVDKLDKVGY
                     HAVECWGGATFDASLRFLHEDPWERLRKLRDGFKNTKLQMLFRGQNILGYRPYADDVVE
                     YFVQKSAANGIDIIRIFDCLNDLRNLQTAVSAANKEKAHAQVALSYTLGDAYTLEYWTD
                     IAKRIEDMGADSICIKDMAGLLLPNKATELVTALKETVKIPIDLHTHYTSGVASMTYLK
                     AVEAGVDIIDTAMSPFALGTSQPATEVMVETFKDTPYDTGFDQKLLSEIADYFRPIRDE
                     ALDSGLLNPKNLGVNIKTLLYQVPGGMLSNLTSQLKEQHAEDKFYDVLEEVPRVRKDLG
                     EPPLVTPSSQIVGTQAVFNVLMGERYKMVTKETKDILLGKYGATVKPFNPEVQKKCIGD
                     EKPITCRPADLLDNELEKLESEMAQYKEQDEDVLTYALFPQVAMDFFKYRQAQKTKVDE
                     KAADKKNGAYPV"
     CDS             complement(11556..12704)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: OAD_beta"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg49_34"
                     /sec_met_domain="OAD_beta (E-value: 4.1e-156, bitscore:
                     510.5, seeds: 229, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSYVTETLSNLIHQTAFFNLTWGNYLMIAVACVFLYLAIKKGFEP
                     LLLVPIAFGMLLVNIYPDIMANPEDMSNGVGGLLHYFYILDEWSILPSLIFMGVGAMTD
                     FGPLIANPISFLMGAAAQLGIYAAYFLAIFLGFNGKAAAAISIIGGADGPTSIFLAGKL
                     GQSALMGPIAVAAYSYMSLVPIIQPPIMKLCTTEKERKIKMDQLRPVSKLEKILFPIVI
                     TIVVCLILPTTAPLVGMLMLGNLFRECGVVKQLTETASNALMYIVVILLGTSVGASTSA
                     EAFLNADTLKIVVLGLVAFAIGTFGGCMLGKLLCKLTHGRINPLIGSAGVSAVPMAARV
                     SQKVGAEADPTNFLLMHAMGPNVAGVIGTAVAAGTFMAIFGV"
     CDS             complement(12721..13089)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: Biotin_lipoyl"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1024:Biotin-requiring enzyme (Score: 63.1; E-value:
                     5.3e-20)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg49_35"
                     /sec_met_domain="Biotin_lipoyl (E-value: 3.2e-20, bitscore:
                     63.1, seeds: 40, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKSYTITVNGTAYEVTVEETGSVSAPAAAPKAAPKAAPAAAPKAA
                     APAAGAGAVKVTASVPGKVVKVAASVGQAVKAGDSVIILESMKMEIPVVAPQDGTIASI
                     DVAEGASVENGDTLATMN"
     CDS             complement(13117..13839)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: OAD_gamma"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg49_36"
                     /sec_met_domain="OAD_gamma (E-value: 2.3e-27, bitscore:
                     86.8, seeds: 234, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTFLVMAALVIGSTSVVFAADKVDDTVKSTLVTTAEGLTDAIVQL
                     KDEEIENYMSSGDDFTTSAMQSWQTSKDELGAKKDSNGETTVTFKDDQYTVTVPLKFEK
                     AEANFVYVFDSKGTPTSMTVDVQYGMGKTLQRAGLNTLMGIGTVFVMLILLSLLISLFR
                     FIPNPEAKKAAEAKAAKAAKEAEAAAIAQTAPAQAEENLADDGELVAVIAAAIAAAEGT
                     TTDGFVVRSIRKVKRNRR"
     CDS             complement(13887..15323)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: CT_Vparvula"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg49_37"
                     /sec_met_domain="CT_Vparvula (E-value: 3.9e-136, bitscore:
                     445.7, seeds: 132, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSNATQSLAGTRITSLLDANSFVEIGQGVTARSTDFNMTANKAPS
                     DGVITGYGVIDDKLVYVYSQDASVLNGTVGEMHAKKITRLYDLAMKTGAPVIGLVDCAG
                     IRLQEATDALEAFGQIYLKQTLASGVIPQITAIFGTCGGGMAVIPSLTDFTFMESKKGK
                     MFVNTPNALEGNNTDKCDTAAADFQSKETGVIDGVGTEDEILGQIRSLVSLLPSNNEDT
                     DNYTECTDDLNRVCADLANCAGDTAIALSQIADNGEFFETKADYAKDMVTGFIRLNGAT
                     VGAVANRSEVYDAEGKKTETFDGSISARGARKAADFVKFCDAFDIPVLTLTNATGFMAT
                     LCSEKMMAKSVGELVAAFADATVPKVNVIIGKAYGTAYVAMNSKSIGADLVYAWDNAEI
                     GMMDASLAAKIMYADADAAELNEKAAQYRELQNGVASAAARGYVDTVISPADTRKYVIG
                     AFEMLFTKREDRPSKKHGTV"
ORIGIN
        1 tcttcggtgc ctgtgcgcac ctgcatcaca taccacattg gatatcttac ctccatattt
       61 tgggtatgct tcgccattct gcctgtgttt caaagcagac tcatacttca agatatgtat
      121 tatccatatc ttcaaacgcg gcaaagcgac gatttaaaga caaaagattt acgtcgtgtt
      181 ttattataac tacatcaata aaaaaatgca acatatttct acaaaaaaac gctttcgctg
      241 ctgccaaaac atgaccagta gcgaaagcgt tcattgtatc ttctttttca gctaaaatta
      301 ttcagctgtg tcttcctttg catctgcaac gattgtgaag tagcaaaggt catctaatgc
      361 gactttgatt gtttttttct ctttgtctac attgatcgga tcaacaattg tccattcctt
      421 tgtttcttca ttgtagcata caagctgaat gttctccatg tcatctgtga tgcttggaac
      481 tgagaattca acttcatatt tgccatctgc gttctttaca gctttgacag agtcaagaac
      541 tttgaactgt atgaaacctg taacgaaatc ttttccgtcc agtttctcaa taacttcttc
      601 aatcgcagct ttgagtgttt catctgtttc ttcttctgca agagtcttca gaacatctgc
      661 gaatccgttc atgtccatct cgccttttcc aactttctca aaagcatctg caactgccgg
      721 aactgcttct ttcagttctt tgaatccatc agtatcttcg atcttctgaa tgatctcata
      781 gacctgggaa tcttcctgaa ctactgtaac atcctttgta cggcttccat ctgcactgac
      841 accaaacgca catcctacac tgaggactgc cgctaacgca agtgccatga atttctttgc
      901 aattttcata atgcacctct ccttttggat tataatttat ttagataata gcacaccttg
      961 cactatctat ctcttaacat aataaaacaa aacataaaga atatcaatca atttttgtta
     1021 taaaacatcg aaataatcat atccgtcaat tcatcttcat ctacatggta ttcatcgaag
     1081 ttctctccct gtgttccttc tcctggaaca gttcgggaat ctgtaatttc attctgtgat
     1141 gctgtcaaaa gttttgcaaa aacatcattt cccatgtttg taactgtata attgtcgata
     1201 ctgtcataca ggcctgttac aaatccggca tctttggatg cctgctcctg tgccttctgc
     1261 agaaacgcct gaagatatgt cttctgacgc tcctgacgga caagagcact ctgactcttt
     1321 cctatgtcac gataacggac aaactgttct gcattctctc cggtcagcgt aaccaccgag
     1381 ccttctttaa aatccggatt tatatcttcc agactgttat ccggcactgt gatctccaca
     1441 ccacctacat aatctgtgat tacagaaatt ccatccatat tcatggcaca atatccctga
     1501 acaggaagac cattcagaag gttggaaact gctgttttca tcaattcaca gctcttctgc
     1561 ctgccatcac cgtacgcata ctgaatatta atatggtctg ttgtcattcc caggcttttt
     1621 cccgcaggat taaagacttc tattctggtc atagaatctc gtggaataaa cagaaccttt
     1681 atcttttctg ttgcacgatc catggacacc aggaaaattg catctgcctg cccggcatct
     1741 acctgtgact gataagtatc tacagtttcc cttgtatcaa ttcccaggaa taaataattg
     1801 ctgagatgat cgttatattt gtatgtctca cctttatatt ccacgatatc actgttttgg
     1861 ctcaagtccg tctgattccg gctgtcactg ttctgaccgc cgttttgtgg cgatgcagca
     1921 tttttctggc ttaacagata ataaccgccg ccaagaacgg aaagaactat gatcaggata
     1981 ataatcaaaa gcatacagat cttgcgctgt ctgatggctt ttcttgtggt ttttgtcatt
     2041 ttcattcctt caatctctgt atttcagtta tctcatcagt ttttgctgat gtaattaagc
     2101 tcctgcaatt tctgtaatat tgcctctgcc attgcctgct gggcctcata ggtagaagac
     2161 ggctgtgcag tcacatttgc aagactgata tagtgttctc cccatttctg gctgagcacc
     2221 tgatccagtg cttcagaggt tacgcttccg tccatagggc gtgttcctac tacaataaac
     2281 tgatctttat tctgaaatgt atttaaaatc tgttcctgct ggtctgccag ttctgcagga
     2341 tcatgattcc agccgccata atatcccatg aagataacag gaatacaatc catatcattt
     2401 cttgtagtct gttcttctgt caaatcacgt attccggtct ctgtcacatt cagctgggca
     2461 ccgtttgcag cctgctgatg tctggtaata tagccctgaa gggtttcatc acttacacca
     2521 gccatcttca tcatggagag agtgccgcct ccctgaagtg ttttattgat tactgtcata
     2581 ttatagccat tatcggtcag aagcttctga agtactgtca tataggaata tgtattggat
     2641 tcttccccat tgatcagatc atctccccag cacacaatgc ctgaagcagc tgtcgtctta
     2701 tcttttgtat cttctgtctt atctgcatcc gttttttctg tgtcttttgt gtcttctgtg
     2761 ttctttgatt taatgtcttc tgtatcttct gcttcttcgg aagatatctc ctccagctct
     2821 tttgcatgtt cttttactgc ttcgtaatct tcaatcccac tctgctggtc gtctgcaatt
     2881 tctgacaggt gtctggattc cttctgttcc gatttataac tggtcacaag aataaagccc
     2941 aggagaactg ccagaagaat gcagataaag cccagtaaga tattcgtctt ttttattttt
     3001 ttcttcctta ttttgctcac ttttccaaat tctcctttat cattgatcat ggtttctgtc
     3061 ttactgccag ataactgccc gtattattta atctgggctt cttcgtcact tctgcgataa
     3121 tactctccat aatgcttata ataagaagaa taatatttgt catcactggt atctatcttg
     3181 ttcataacag ctccaagaat acggcatccg cttctttcca gctgtttaaa tgctttctgt
     3241 gcatcccggt acctgacatt tcccggttcg atcagaaaga ctgcaccatc gcagcatctt
     3301 cctatcactg ctgcatcaat tactgttccg ataggcggtg tatcgatcag gatataatta
     3361 taatattctc tgatttcctt taagaatacc ttaaagatat tctcactgag aagtcctgac
     3421 ggattcggtg cacttggacc tccgaatatg atatccatat tcggaaaatt tgtagaataa
     3481 ataatctcct gtaatcccac ctgaccgctc agaagctgtg agagaccttt cacttcctct
     3541 tccacaccca gtcgtccggc atatgcagtc ttcctgatat ccgcatccag aaggagaacc
     3601 ttcttaccga tacttccaag ctcccgggca aggctgagta ctacatcact cttaccttcg
     3661 tttggataac agctcgtaac cagaattgtc tttatgctct gacccgacag ctgaatattg
     3721 gtacgcagcg ttttgatcgc ctcactgtaa aaataatccg ggtttctttt atctgttaaa
     3781 ttgagtttct tcattgctca gattcctcca tcagtttaat ggtgcttctt attcttgttc
     3841 tttgatttcc tgttcttcgc atttataaaa tcttttctgt caggaacctt ggcaagaaca
     3901 gaaactccca ggtatttctc aatatcttcc tctgtcttaa tagtatcatc cattacagcg
     3961 tatacaacca caattgccgc acatgcaagg aaaccgagta agaagccgag tgctgcattc
     4021 ttctttacac ttggagaagt tcttacagta gcaatcttac cgacttcaat aatctttggc
     4081 ggaataactt ccattttatc gccaatatag gatgaagaaa cattcgcgat ctcatctacg
     4141 atcttctttg ccattttaga atctgtatta ttgacagtaa tctcaaggat acgggtatct
     4201 gtaggattat tgatacttac gctttctttc agctgttctg cagtcatatc cagatccaaa
     4261 tctgaaatta cctgctccat cacaggggta cttgtaatca gaactgtata atcactggtc
     4321 aggctggcac ctaactgcag gtccgccagt gatgtcagtg tggtttcttt tgaaagtaca
     4381 aggatactgg atgtggagct gtaaatcggt gtcatcaaaa actgtgtata cgctgctgca
     4441 atacagcctc cgacaagagc aaccatcagt accagaagga tttttttctt gagcgcataa
     4501 aatatttcca gtaagtcgat ttcgacttca tcatcatttg catcgggtct ctgtgctttg
     4561 ctgctctcaa agttactgtt caaattgtct aacatctgat aatttccttt tccctttttt
     4621 ctttatagtt ttgtacatta ctgttcacag gtaatattct gtcttatgta tttctgaaag
     4681 taaacagcaa aattgacata aaccgatttt attgtatatc agccaataaa aaaagtcaat
     4741 ctgtagcttc atgtttttgt ttctgtttca gaatttctgc aggattatga ataaacagtt
     4801 catctgcata gtcctgcccg aatttcgctg aaaccatacg atatgcctct ccaatcctgc
     4861 tgctcctctt tgcactgttg tgacagtctg atccgacgaa atgaaggagt ccgtctttca
     4921 tgattttatt acagtaccgt ttagtaaaaa atccgtcttt tcctgtgatg ctgtctgcat
     4981 taatctgcat atagacgccc atatctgcca gttcttccac aaaatccaga ctgttgcgtg
     5041 tggcttcgta acgttctata tgtgctatga tcggcttata tcctccggag agcaatgcac
     5101 cgagacgttc ccgtatatag ctttcttccg aattatggga aaattctgta agaacatacc
     5161 gcgaaccggc cattgtcatt actttctgtt ctctgagcat gggaagcatc tccatattgg
     5221 cgtgaaactc acatcccaga tacacatgga gatccgggct tatctctgat gccgctttct
     5281 ccaccagtct gaactgctct ctgactttct ccgcaggtgt ttcaaacatc cgaaagcgga
     5341 aatggggagt tgtaataacc gtccgcacgc cctgttcata ttccatccgg agtaatttta
     5401 cggtttctcc tatatctgtg gctccatcgt ctacaccggg tacaatatga cagtgtatat
     5461 cataaattcc ttttatggac atcctatcat tccttcctga ctgtctgcag catttctgat
     5521 gctcctgtaa ctgctgacca cattcgtaat ctaaaaaaac aatcaaccgg ctctgtatga
     5581 tcatcctcat acaaagccgg ttgctgaata tttatgagta ttctcttaat tattcttctg
     5641 tagcttcctc agccggtgcc tcaagagctt tcatgctcag gctgatcttc ttgtcttcgc
     5701 cgttgaagtc aacaacctta gcttcgatct cctgtccgat tgacagtacg tctgctggtt
     5761 tggcaacgtg ctctctggaa atctgggata cgtgaagaag tgcatctaca ccaggtgcaa
     5821 gctctacgaa tgcgccaaag tctgtcatac gtgcaacttt acctttaact acgtttccta
     5881 cagcgaagtc ctcagctgct gtgagccatg gatttgcttc cgggaattta agggaaagtg
     5941 cgatcttctc tccgttgatc tctttgataa gaactttgac tttatcgcca acagtgaata
     6001 ctttcttcgg gttctctact ctgccccagg acatttcgga gatgtgaaga agtccgtctg
     6061 ctccgccaag atcgatgaat gcaccgaaat ctgtaacgtt cttaactgtt ccttcaactg
     6121 tgtcgccaac atggattctc tccattaatt ctttctgttt ctctgctttc tcagcgagaa
     6181 gaagctgttt acggttaccg atgatgcggc gtcttctcgg gttgaattct gtgataacga
     6241 attcgatctc ctgatctgca tatttggaaa ggtctttctc gtatgtgtcg gaaacgaggc
     6301 ttgcaggaat gaatactctt gcttcgtcta cgtttacaca aagtccgccg tcaagtacct
     6361 gagttacagg agcttttaat acttcctgat tctcaaatgc ttcttcaaga cgtttgttgc
     6421 ctttctctgc tgccagtctc ttgtaagtaa gagtaacctg accttctcca tcgtttactt
     6481 tgagaacttt tgcttccatt gtgtctccaa cgtgaacagc atctgtgagt acaaggcttg
     6541 catcgttaga gtattcgttc tttgtgataa taccgtctgc tttataaccg atattcagaa
     6601 taatctcatc ttcttttaca tcgatgacag taccctgtac aatctctcca tttctgatag
     6661 tctttacgga atcttccagc atttgttcaa aacttaattc tgacatgttc ttgaacctcc
     6721 tcaataattt tgtttggggt ggaagcccct gctgtaatac ctacataact actgcattgg
     6781 aacatttcag aatccaagtc tacaggtgtt tgtatatagt aagtatttcc acattccttt
     6841 ttacatattt caaacagctt ttgagtattg gaactgtgcc ggccgcctac gaccagcata
     6901 gtgtctacct ctccggctat gttttttgct tctctctgcc gttcttcggt agcattacaa
     6961 atagtgttta aaatattgag aatatttaaa acattattat catacctctt tttgcaaaga
     7021 atttcaacta aatctttaaa tttgttgtaa ttaaatgtcg tctgggacac aatacttatt
     7081 tttttgcctt ttggggatac aaatacttcg gcttcttctt tgtttccgat caccgtgtac
     7141 ggtccctgac accagccgca gatgccctgt acttcggggt ggtctttgtc gccgatgatg
     7201 atgatgtggt ttcctgcaag gctttctttt tccacgatcc tgtggatttt cagaacgaag
     7261 gggcaggtca catctacgta ggagatattt ttttctttca gcttatcgta gatgggtttg
     7321 cctacgccgt gagagcggat gactactgtt ccgttctgca gggtgtcatc cggggaatcc
     7381 aggtctgctt ccgtgataac gtggacgcca cgggcttcca gatccgctac tacgccttca
     7441 ttgtggatga tcggacccag agtgaagatt ggtttctgtt ctgtgtcaat cagctcgtag
     7501 accttgtcca ctgcacgttt gacgccgaag cagaagcctg ctgtttctgc tacttttact
     7561 ttcataaaat aatccttctt aaattatttc tgcacttttt ccttatatac attaagaatc
     7621 gcatttacaa catcatcaat tcccatttcc gaagaatcta cgagcactgc gtcctctgcc
     7681 tgtttcagag gtgagatttc gcggttcatg tcgcgttcgt cgcgctcgat gatgtctttt
     7741 cggatctggt ccaggtcgaa ggcttctccc ttctgctcat attccagtgc tcttcttttt
     7801 gctctggtgt ctgcgcttgc tgtgaggtag atttttactt ctgcgtttgg aaggatagtt
     7861 gtgccgatat ctctgccatc catgactacg tcgtttttct ctgccagagt tctctgaagt
     7921 ttcagaagat gagctctgac tttcgggttt gcggagcttt tggatgccat gtttcctacc
     7981 tgttcggtgc ggatcatagc atttacgttc tctccgttaa ggatgacaat ctgttctccg
     8041 tttttgtatt cgatggagat gtcagcgccg gaacatacgg cctcgatctc ttcctgattt
     8101 tctccgttta cgccatggtt cagaagatat aaagccattg ctctgtacat ggctcctgta
     8161 tctacataga taaatgataa ttctttcgct actttctttg cgatggtgct ctttcctgct
     8221 cctgcaggtc cgtcgatggc tatgttacat cccattttcg tggttcctcc tgtttctatt
     8281 attcaaacag attttctctg ttttattatt aatgtttatt aatcagtcaa gcggatattc
     8341 gcaatccgct tcgctacttg ctcataaccg aatcatagat ataattcgca tacacggtac
     8401 tcatcatctg cttgtttctg ttgtttctat agtaagcagc ttactgtatg gcctgtgctg
     8461 ccagatatgc ggtagaccag gcaatctgta agttatatcc acctgtcact gcatccagat
     8521 ccagtacctc gcctgcgaag taaagacctg agattttctt tgattccatt gttccgggat
     8581 tgatctcttt gacagagacg ccgcctctgg tgatgatggc ttctttaaac tcacccattc
     8641 ctgtgattgt gaaggggaag gctttgataa ggtcaatgaa gtgctggcgt tcttctctag
     8701 aaatgtcgtg gattttcttc tctgcgggga ttccacccag ttccagcatt accggagtca
     8761 gagatgacgg gaaaagtacg ccaatcacat tcttgaactg tttgtttggt cctgcttcaa
     8821 attcacgcag gatcctggca tccagttgtt ctctggtgag tgcaggcttc agatccagat
     8881 atgcggacag ttcgccgttt ggtgctttcg ccagttttgc accgatgtgg gcactggcgg
     8941 agaggatcat gggacctgtg actccgaaat gggtgaacat catctctccg aaatcctcat
     9001 agagtacttt ctttccattc tttatggtaa gtcctgtatt cttaagggaa agtccctgaa
     9061 gcttagggac atagtcttct tttgtcttta atggcacaag ggagggagca atgtccgtga
     9121 ctttcagtcc cagttctctt gcgaagcgat atccgtcacc tgtggaaccg gtactctgat
     9181 aagagaatcc gccagttgcc acgatgactg catcgccttc catgaaggtt ccgtctgtaa
     9241 ggatgactcc tgtgatcttc tcctgcggta tgtcaggtga tttttttcct tttctgcctt
     9301 ttcctgcatc agatcctgat tctgttaatg cggcttctga ttcaagggta tttgctgaat
     9361 ctgttacagg tttctttaca atttcctgta cagcagtgtg aagatgaatc tttgctcctg
     9421 ctttcttcag ttcacgctcc agtgcgcgga tgatgtctga agaatggtca gactgtggga
     9481 atactctgtt tccacgctct accttcagag ggacaccagc tttctcaaag aactccatca
     9541 catcctgagg ggtaaatgaa tagaaactgc tgtagaggaa cttgggattg ctcatcattg
     9601 caggaaagag ttcttctgtg tcgcaggcat ttgtcacatt gcatctgcct tttcctgtga
     9661 tgaagacttt ctttcccagt ttctcgttct tctctaatat atgaacttca tgatggttac
     9721 gggctgcaaa aacccctgcc atcattccgg cggctccgcc gccgattatt ataactttgc
     9781 tcatggaata ttctcctgta tttattttac cctgcagatt atctatttca tcatggttcc
     9841 acgtctccgc ttcgctacga tcaatataga tatgtaccac tggcagcata tacccattgg
     9901 cacattatat tcccgggtat catattcttt cataataacg caaaggagcc tgcttacgca
     9961 agctcctttt ttcgtttgga catatttaat tactgattaa ttatacagga tatgctccgt
    10021 tctttttgtc agctgctttc tcgtcaactt ttgttttctg agcctgacgg tatttgaaga
    10081 agtccatagc tacctgtggg aacagtgcgt atgttaatac gtcttcatcc tgttccttgt
    10141 actgagccat ttcgctctca agtttctcaa gctcgttgtc aagaaggtct gccggacggc
    10201 atgtgatcgg tttctcatcg ccgatgcact tcttctgtac ttccggatta aacggtttta
    10261 cagttgcgcc gtattttcct aacaggatat cttttgtttc ttttgtaacc attttgtatc
    10321 tctcgcccat aagtacgttg aatacagcct gtgtaccaac gatctgggaa gacggagtaa
    10381 caagcggcgg ttcaccaagg tctttacgta cacgcggaac ttcctcgaga acatcgtaga
    10441 atttgtcttc tgcgtgctgt tcttttaact gggaagtcag gttggagagc ataccgcccg
    10501 gtacctgata cagtaaagtc ttgatgttaa caccaaggtt cttcggattg agcagtccgc
    10561 tgtcaagagc ttcgtcacgg atcggacgga agtagtcagc gatctcggag agaagcttct
    10621 gatcaaatcc tgtgtcgtat ggtgtatcct tgaatgtctc aaccataacc tctgttgcag
    10681 gctgggatgt tcccagtgcg aatggagaca ttgctgtatc gatgatatcc acacctgctt
    10741 ctactgcttt taagtaagtc atggaagcta cacctgaggt gtaatgtgta tgaaggtcga
    10801 tcgggatctt aactgtttct tttaatgctg taacaagctc tgtagctttg tttggaagga
    10861 gaagacctgc catatctttg atacagatgg aatcagcgcc catatcttcg atacgttttg
    10921 caatgtctgt ccagtattcc agtgtgtaag catctcctaa tgtgtaggaa agagctacct
    10981 gtgcatgagc cttctctttg tttgcagcgc ttactgctgt ctgcaggtta cgaaggtcat
    11041 tgaggcagtc aaaaatacgg atgatgtcga ttccgtttgc agcagatttc tgtacgaagt
    11101 attctacaac gtcatctgcg tatggacggt atccaaggat gttctgtcca cggaaaagca
    11161 tctgaagttt tgtgtttttg aagccgtcac gtaatttacg aagtctttcc catggatctt
    11221 cgtgaaggaa acgaagggat gcatcgaatg ttgcaccacc ccagcactct actgcgtgat
    11281 agccgacttt gtcaagttta tctacgatcg gaagcatctg ttctgtggtc atacgtgttg
    11341 cgatctggga ctgatgagca tcacggagaa tggtttccac aattttaaca ggttttttct
    11401 ctaattctgc cattattaaa tctcctttat agttctgttt aatcggatat tcgcaatccg
    11461 cttcgctact tgctcataac caaatagctg ctccgcagct tatcagaagg agttgcactc
    11521 ctcctgatac aagcaagata gcttgcttga tttggttata ctccgaaaat agccatgaat
    11581 gttccggctg ctacggctgt accgataaca ccggcaacgt tcgggcccat tgcgtgcatc
    11641 agaaggaagt ttgtaggatc tgcctctgca cccactttct gggatacacg ggctgccata
    11701 ggtactgcgg atacacctgc ggaaccgatc agcgggttga tacgtccgtg agtcagtttg
    11761 cagagcagtt taccaagcat acatccgccg aatgtaccga ttgcgaatgc aacaagacct
    11821 aaaactacga tcttcagagt atctgcgttt aagaatgctt ctgcacttgt ggaagcacct
    11881 acggatgtac ccagaaggat aactacgata tacatcaggg cattggaagc tgtttctgtc
    11941 agctgtttta caacaccgca ctctctgaac aggttaccaa gcatgagcat accaaccagc
    12001 ggagctgttg taggcaggat caggcagaca acgattgtga taacgatcgg gaacaggatc
    12061 ttctccagtt tggaaaccgg gcgaagctga tccattttga tcttacgttc tttctctgtt
    12121 gtgcagagtt tcatgatagg cggctggatg atcggaacca gtgacatata ggaatatgct
    12181 gccactgcaa tcggtcccat cagtgcagac tgtccaagtt tacctgcaag gaaaatggaa
    12241 gtcgggccgt cagcaccacc gatgatggag atagctgctg ctgcttttcc gttgaatcca
    12301 aggaagattg caaggaagta agctgcatag ataccaagct gtgccgcagc acccatcagg
    12361 aagctgatcg ggtttgcgat aagcggaccg aagtctgtca tggcacctac acccatgaag
    12421 attagggatg gtaagatact ccactcatca aggatgtaga aataatgaag aagtccacct
    12481 acaccattgg acatatcttc cggatttgcc ataatgtccg gatagatatt tacaagcagc
    12541 ataccgaatg cgataggaac aagcagaagc ggctcgaatc ctttcttgat agcaagataa
    12601 aggaatacgc aggctactgc gatcatcagg taattgcccc atgtcagatt gaagaatgct
    12661 gtctggtgaa tcaggttgga caatgtttct gttacataag acatttgact acctcccgtc
    12721 ttagttcatt gttgctaaag tatctccgtt ttctacagag gcaccttctg caacatcaat
    12781 gcttgcgata gtaccgtcct gaggagctac tacagggatt tccattttca tggattcaag
    12841 aataattacg ctgtctccgg cttttactgc ctgtccaacg cttgctgcta ctttgacaac
    12901 tttaccaggt acggaagcag ttacttttac tgcgccggcg cctgctgcag gagctgctgc
    12961 tttcggagct gctgcaggtg cagccttagg tgctgctttt ggagctgctg caggagcgga
    13021 tacgcttcct gtttcttcaa cagttacttc atatgctgta ccatttactg taattgtata
    13081 gcttttcatt ttaaaatcct cctaaataaa tgacaattat cttctatttc tttttacttt
    13141 acggatggaa cgaactacga agccgtctgt tgtagttcct tctgctgctg cgatggctgc
    13201 tgcgataaca gctaccagct ctccgtcatc tgcaaggttc tcttctgcct gtgcaggtgc
    13261 tgtctgtgcg atggctgctg cctctgcctc ttttgcagct ttggctgctt ttgcttctgc
    13321 tgctttcttt gcttccggat tcggaatgaa tctgaacaga gagatcagaa ggcttaataa
    13381 aatcaacatt acgaatacag ttccaatacc catcagagta ttaagacctg ctctctgaag
    13441 agtcttgccc ataccatact gtacatctac agtcatggaa gtcggtgttc cctttgagtc
    13501 aaagacatat acaaagtttg cttctgcttt ctcaaattta agaggaacag taactgtgta
    13561 ctgatcatct ttgaaagtta cagtagtttc accattgctg tccttctttg cgccaagttc
    13621 atccttggat gtctgccagg actgcatggc acttgttgta aagtcatctc ctgaactcat
    13681 gtaattctcg atttcttcat ctttaagctg gacaatggca tctgtcagcc cctctgctgt
    13741 agttaccagc gtggacttaa cagtatcatc aaccttatct gcggcaaata ccacagaggt
    13801 gctgccgatc accagcgcag ccattacgag aaatgtcatg aatacagaag ttattttttt
    13861 gatcattttc atatgcgtca ccccgcttag accgttccat gtttcttaga cggacgatct
    13921 tctctctttg tgaacagcat ctcaaatgca ccgattacat attttcttgt gtcagccggg
    13981 ctgatcacag tgtcaacata gcctcttgct gctgcggaag caacaccatt ctgaagctct
    14041 ctgtactgag cagctttttc attcagttca gcagcatctg catctgcata catgatcttg
    14101 gctgccaggg aagcatccat cataccgatc tctgcgttat cccatgcata tacaaggtct
    14161 gcaccgatag atttgctgtt cattgccacg taagctgtac cgtaagcttt gccgatgatc
    14221 acatttacct tcggaacagt tgcatctgcg aatgcagcta ccagttcacc tacggatttc
    14281 gccatcatct tctcgctgca taaggttgcc atgaagcctg ttgcgtttgt aagtgtaagt
    14341 accggaatat caaaagcgtc gcagaatttc acgaaatctg ctgcttttct tgcgcctctt
    14401 gcagagatgc ttccgtcaaa tgtttctgtt ttcttgcctt ctgcgtcata tacttcgctt
    14461 ctgtttgcaa cagcacctac tgtagcgccg tttaaacgga taaagcctgt aaccatgtct
    14521 tttgcatagt ctgcttttgt ctcgaagaat tcaccgttgt cagcgatctg agaaagtgcg
    14581 attgctgtgt cacctgcaca gtttgcaaga tctgcgcata cgcggttaag atcatctgta
    14641 cactctgtgt aattgtctgt gtcttcatta ttagaaggaa gaagtgatac taaggaacgg
    14701 atctggccaa gaatctcatc ctctgtacca acgccatcga tcacacctgt ctctttgctc
    14761 tggaaatcag ctgctgctgt gtcgcatttg tctgtgttgt ttccttccag tgcgtttggt
    14821 gtgttgacga acatttttcc ttttttggat tccatgaatg tgaaatctgt cagggacggg
    14881 ataactgcca taccaccgcc gcatgttccg aagattgctg tgatctgcgg gatcacaccg
    14941 gatgccagtg tctgtttcag atagatctgt ccgaaagctt ccagtgcgtc tgttgcttcc
    15001 tgaagacgga tacctgcaca gtcaacaagt ccgataaccg gagcgcctgt tttcatggca
    15061 agatcataaa gtcttgtgat cttctttgca tgcatttcac caacagtacc gtttaataca
    15121 gatgcatcct ggctgtatac ataaaccagt ttgtcatcga tcacaccata tccggtgata
    15181 acaccgtcag atggtgcctt gtttgcagtc atgttgaaat ctgtggatct ggctgttaca
    15241 ccctgtccga tttcgacaaa actgtttgcg tcaagcaaag aagtaattct tgtgcctgct
    15301 aagctttgtg ttgcattact cattcttgtt tgccctccat ctttatgaga atatttaaaa
    15361 gttaacccaa aaatttagcc gattttaatt ttaccttttc cggcagaaaa tttcaacatt
    15421 tatttgtcat tttcgttaaa aatatagcag aaaaatttgt caggtttctc caaattttgt
    15481 ttttttgagc atttcttcct atttaaaagg aaaaacataa tgaaaagcac ttatcagcat
    15541 attttttcac ctctgaccgt aaaaaatatg actatcaaaa accgtattgt tatgatgcct
    15601 atgggcacaa aagatcatcg atggaactct ggaagaaaga aatatcctta atacactgac
    15661 tcagatggga taccgtgaac ctcacatggc taaagtcacg tgcttccgga cgctttaggc
    15721 gtcagacta
//
