LOCUS       gnlProkkaFKHCHIMF_61   21589 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|FKHCHIMF_61.
ACCESSION   gnlProkkaFKHCHIMF_61
VERSION     gnlProkkaFKHCHIMF_61
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2024-11-17 05:28:01
            Original ID  :: gnl|Prokka|FKHCHIMF_61
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 12134
            Orig. end    :: 33723
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..21589
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:11589]"
                     /cutoff="20000"
                     /detection_rule="(TIGR03973 or SCIFF or (cds(PF04055 and
                     (TIGR04085 or SPASM)) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]) and not (TIGR01716
                     or subtilosin or TIGR02111 or TIGR03966 or TIGR04103 or
                     (YcaO or TIGR03604))))"
                     /neighbourhood="10000"
                     /product="ranthipeptide"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..11589
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(TIGR03973 or SCIFF or (cds(PF04055 and
                     (TIGR04085 or SPASM)) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]) and not (TIGR01716
                     or subtilosin or TIGR02111 or TIGR03966 or TIGR04103 or
                     (YcaO or TIGR03604))))"
                     /neighbourhood="10000"
                     /product="ranthipeptide"
                     /protocluster_number="1"
     cand_cluster    1..21589
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(TIGR03973 or SCIFF or (cds(PF04055 and
                     (TIGR04085 or SPASM)) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]) and not (TIGR01716
                     or subtilosin or TIGR02111 or TIGR03966 or TIGR04103 or
                     (YcaO or TIGR03604))))"
                     /kind="single"
                     /product="ranthipeptide"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..21589
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="ranthipeptide"
                     /region_number="1"
                     /rules="(TIGR03973 or SCIFF or (cds(PF04055 and (TIGR04085
                     or SPASM)) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]) and not (TIGR01716
                     or subtilosin or TIGR02111 or TIGR03966 or TIGR04103 or
                     (YcaO or TIGR03604))))"
                     /tool="antismash"
     CDS             605..1555
                     /locus_tag="ctg49_14"
                     /transl_table=11
                     /translation="MQKDYETFVEKLEIGIYEATGIPRENISFEKEGGRFAPVGDRLLV
                     KFAEHDDAWEVCGLYTQELFKSYQNGSPFEEIIKEITDDLNRIKKADIYEKTRVIRDYE
                     KTKPRLFIRLLNADKYSADLQDAVYKTLGDIALVLYMKVTEYEGCATSTKIRQGMLEQW
                     GKECDEVFQEAILNTYFMSPPRIYRWEQMIFNPEYEGESFMNLGDKCELKKDAMGNCLS
                     TTKKTNGAVAVFLPGVAEQLAYMLDSDFYMVFTSVHEVMIHNDKFVEPEDLQCVLRDTI
                     REATPKEDYLTSRIYQYNRETHKFICVTPLEKDEK"
     CDS             complement(1630..2424)
                     /gene_functions="transport (smcogs) SMCOG1000:ABC
                     transporter ATP-binding protein (Score: 168.4; E-value:
                     3.5e-51)"
                     /gene_kind="transport"
                     /locus_tag="ctg49_15"
                     /transl_table=11
                     /translation="MLELKNIYKTFNPGTINEKRALNGLNLKLNEGDFVTVIGGNGAGK
                     STMLNAVAGTWPVDEGQILIDNIDVTKLSEHKRATYLGRVFQDPMTGTAATMGIEENLA
                     LAKRRGKSRLLRSGITKAEREEYKELLKILGLGLEDRLTSKVGLLSGGQRQALTLLMAT
                     LQKPKLLLLDEHTAALDPKTAAKVLEITDMIVNRDHLTTLMITHNMKDAIAHGNRLIMM
                     MEGKIILDIQGEEKKKLTVKNLLDQFEKASGEEFSNDSALLG"
     CDS             complement(2427..3344)
                     /gene_functions="transport (smcogs)
                     SMCOG1113:inner-membrane translocator (Score: 66.8;
                     E-value: 2.7e-20)"
                     /gene_kind="transport"
                     /locus_tag="ctg49_16"
                     /transl_table=11
                     /translation="MQIITLITALPGAVAQGLIWGIMAIGVYITFRILDIADLTVDGTM
                     CTGGAVCIMMMLSGHNVWISMLAATLAGMLAGLATGIFHTFMGIPAILAGILTQLSLYS
                     VNLKIMGKANQAINVDKYNLLVSLRHIKNASLSKNTIFIVAVMCILLIAILYWFFGTEL
                     GCSLRATGCNPNMSRAQGINTNRNKVLGLMISNGLVGLSSALLAQYQGFADVNMGRGSI
                     VIGLAAVIIGEAIFGRIFRNFALRLLAVIFGSILYYLVLQIVIWMGIDTDLLKMLSAIV
                     VALFLAFPYWKGKYFNKPAKRGGK"
     CDS             complement(3495..4481)
                     /locus_tag="ctg49_17"
                     /transl_table=11
                     /translation="MKRKALAITLAAAMAMGTCAVTASAADGDKYTIGICQLVQHEALD
                     AATQGFKDEVTKELGEDAVTFDEQNAQGDSNTCSTIINSFVSNNVDLILANATPALQAA
                     AAGTSDIPILGTSVTEYGVALGLDDFDGTVGGNISGTADLAPLDQQAAMLNELFPDAKN
                     VGLLYCSAEANSQYQVDTVKAELEKLGYTCEYYAFSDSNDLSSVATTATDASDVIYVPT
                     DNTVASNTEIINNICLPAKVPVITGEEGICSGCGVATLSISYYDLGVTTGKMAVKILKD
                     GEDISTMPIEYAPNFTKEYNKDICEELGIEVPDDYVAIGEAAEETAK"
     CDS             4745..5509
                     /locus_tag="ctg49_18"
                     /transl_table=11
                     /translation="MAYSIMLDAGHGGQDPGAVYKGRQEKNDNLKLALAVGEILKNKGI
                     DISYTRTGDVYQTPFEKAQLANQAGVDYFISFHRNSSPKENQYNGAEVLIYDKSGIKYQ
                     MAENILGALGEVGFREIGVKERPGLVVLRRTRMPALLIETGFINSEEDNKLFDNKFSDI
                     AQGIADAILGSLDEETVQEPLYYRVQTGAFRKKENADRMLYQLLEKGYPSFMLHENGLY
                     KVQTGAYQQIGNAVNMEQRLRDDGYSTVIVTK"
     CDS             5791..6390
                     /locus_tag="ctg49_19"
                     /transl_table=11
                     /translation="MNDVYEKFLKSSEEFIFAENKPEKSDIIFVPGNGYPQMAEKAAEL
                     FKKGMADWILPSGKYSVVNGKFSGVLEKSNVYDKEYGTEWEFLRDVLIKNGVPDQKILK
                     EDQATFTYENAIYSRQVTDHAELEIERAILCCKSYHARRCLMYYQLLYPKTEFYVVPVN
                     ADGITRENWKKNEEGIDAVTGELSRIVKQFSLMLER"
     CDS             complement(6394..7677)
                     /gene_functions="other (smcogs) SMCOG1273:hypothetical
                     protein (Score: 354.6; E-value: 1.3e-107)"
                     /gene_kind="other"
                     /locus_tag="ctg49_20"
                     /transl_table=11
                     /translation="MDSSIAFQAVAILILIALSSFFSSAETAMTTVNKIRIQSLAEQGN
                     KRAVILEKIISNSPKMLSTVLIGNNIVNMSVSSLMTTLTIKILGNAYVGITTGILTLLI
                     LIFGEITPKNLATIHAEKLSLAYSRIIYGLMILLTPVVFIVNKITEGVLVILHVNPDEK
                     ANAMTEHELRTLVNVGEKDGVIENEEKQMIYNVFDFGDSTAKDVMIPRIDMTFIDINFS
                     YDELMAVFSEDMHTRFPVYEDNTDNVIGIINMKDLLVYPKDKPFSIRNILREPYFTYEY
                     KATADLMIEMRKASVNLAIVLDEYGATAGLVTLEDLLEEIVGEIRDEYDEDEVEDIKEI
                     QPEREYVVQGSAKLDDINEALHINLESEDYDSIGGYIIEQLDCLPKEGQSVTLESGIRL
                     VVDRLDKNRIELVHIWLPEKKTETEEQP"
     CDS             8022..9527
                     /locus_tag="ctg49_21"
                     /transl_table=11
                     /translation="MSNNIRIRKNKLKGTGILAAAALTAALIAGNNIPGVTRQVSAAES
                     QENTVSSLIPDNITLDKPVELADVELPATEYGTFEWADGSFVPAQRVQSCEVLLIPAEG
                     QDLSHVDGWDPESGAVVGYINVIVNSITDSDNVDKTEGSGKTDPTENADPTETPETSSE
                     KPAADENADTDNKEDKESKSDQDNKTDTDNEENKIEEDKTDNKNNKDNNSNADKTDKDT
                     ETTGKLEPADDMTQDKEDTKKDDEDGAGDNIFDNPVLPDDKDDRPTDAEDSLSDEEKEE
                     RAALNHTCDGITVSGVNLPWYVQFRVSSGDSYQFTNESDAMIFQSYEFELWDLKNNTEY
                     EIPNGDYISVTVPVKSGYQYTIEHLLDNGATETIIPSVENGIMVFSTHSFSPFGIAGSR
                     QLVGPDAGNDTDDTDAVTPAPASSDSQSSDSGKNNTVSVNDSSDSNNGSSSDQNDNSTE
                     NKAVKNNNTVNTGDTTSIMPFVILFVAAAVIAGVAVFIKKRKK"
     CDS             9577..9927
                     /locus_tag="ctg49_22"
                     /transl_table=11
                     /translation="MKVRAILKSLLFAYALTGVALLLLALVLFAFDLGETAVDAGIIII
                     YVLACFMGGFMAGKIVRKDKYLWGVITGLAYYVLLLTVSVMAKGGWDMSAAHAVTTFFM
                     CTGGGTLGGMLS"
     CDS             10001..10141
                     /gene_functions="biosynthetic (rule-based-clusters)
                     ranthipeptide: SCIFF"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     ranthipeptide: TIGR03973"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg49_23"
                     /sec_met_domain="TIGR03973 (E-value: 1.4e-27, bitscore:
                     87.3, seeds: 29, tool: rule-based-clusters)"
                     /sec_met_domain="SCIFF (E-value: 1.7e-27, bitscore: 87.0,
                     seeds: 37, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MEHIKTLNTKNLQNTVKKGGCGECQTSCQSACKTSCTVGNQSCEQ
                     K"
     CDS             10222..11589
                     /gene_functions="biosynthetic (rule-based-clusters)
                     ranthipeptide: PF04055"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     ranthipeptide: TIGR04085"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     ranthipeptide: Ranthipeptide_rSAM_RRE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_12"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg49_24"
                     /sec_met_domain="Ranthipeptide_rSAM_RRE (E-value: 6.7e-29,
                     bitscore: 92.0, seeds: 20, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_12 (E-value: 4.6e-16, bitscore: 51.3,
                     seeds: 84, tool: rule-based-clusters)"
                     /sec_met_domain="PF04055 (E-value: 3.9e-14, bitscore: 45.3,
                     seeds: 518, tool: rule-based-clusters)"
                     /sec_met_domain="TIGR04085 (E-value: 1e-19, bitscore: 62.7,
                     seeds: 281, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSLIHRYKSNGFNIVLDINSGCIHLVDEVTYEVLPYLEEGLGTEA
                     IAEKLENKYNREDIETSVRECNKLKEDGMLFTKDVYENVIEEFSNNRQTVVKALCLHIA
                     HDCNLACRYCFAEEGEYHGRRALMSYEVGKKALDFLIANSGSRKNLEVDFFGGEPLMNW
                     QVVKDLVKYGREQEKLHNKKFRFTLTTNGVLLNDEVMEFCNKEMGNVVLSVDGRKEVHD
                     YMRPFRKGAGSYDLIMPKFQKFAESRNQDKYYVRGTFTHHNLDFSKDVLHLADLGFKQI
                     SVEPVVAADTEEYAIREEDIPQIMEEYDTLAKEMIKREKEGKGFNFFHFMIDLTGGPCV
                     YKRLSGCGSGTEYLAVTPWGDFYPCHQFVGEEQYLMGNVDEGITKPEIQKEFGGCNVYT
                     KKDCKDCFARFYCSGGCAANAFHFQGDIKGNYEIGCELQRKRVECAIMIKAALACD"
     CDS             11701..14109
                     /locus_tag="ctg49_25"
                     /transl_table=11
                     /translation="MKKSKGIVVLLLTLILTVFFCFTAAVGIGPTGTGAAKHINTGLDL
                     AGGVSITYQAKESNPTSEEMSDTIYKLQKRVEQYSTEAQVYQEGSDRITVEIPGVTDAD
                     TILNDLGKPGSLYFITKEDADGNQNFTTGQDGYVLSRTMDEIKESGSVVLEGSDVADAQ
                     GGAIQNQNTSAKEYVVSLTLTSDGENSGKTKFAEATKNNVGKQIAIVYDNNIISAPNVN
                     EEISGGKAQISGMSDLEEAQNLASYIRIGSLGLELEELRSSVVAAQLGEEAISTSVLAG
                     AIGLIIVIIFMIIAYRVPGVVAGIALILYTSLMLITLNAFDITLTLPGIAGIILGIGMA
                     VDANVIIYARIREEIGAGVSVRNSIKSGFSKAFSAIFDGNITTLIAAFVLMWLGSGTVK
                     GFAYTLALGIVISMFTALVVSRLIVNALYAVGVRDPKFYGSAKERKAVDFLGKKKVFFA
                     ISIILILCGPAAMFANSHAGNKALNYSLEFSGGTSTTVTFNEDMDIKTIDSEVTPVVEE
                     VTGDKNVQPTKVVGTNQVVIKTRSLNQSEREALQSALVEKFGVDDSTISTESISSTVSS
                     EMRRDAIVAVIVATICMLLYIWFRFKDIRFASSAVLALLHDVLVVLAFYAIARVSVGNT
                     FIACMLTIVGYSINATIVIFDRIRENLHSGSREKLAEIVNTSITQTLTRSIYTSFTTFV
                     MVAVLYIMGVSSIREFAAPLMVGVLVGAYSSVCITGALWYVMKKKFAGKGQPAIAAASA
                     SAKSSSKPKKARDVSQKDPTQPKKKNRKRVAERLAAEEAAKKQQNDDAE"
     CDS             14191..15903
                     /locus_tag="ctg49_26"
                     /transl_table=11
                     /translation="MEKWVIAAKRADFNQIGQQFHIDPVIARLIRNRDVIGEDKIREYL
                     SGTVQELPSPWLMKDMEKAVDILEKKISQKAKVRIIGDYDIDGVTSTYILMKGLARIGA
                     DVDTYIPDRVADGYGIHAHLIERAETDRIDTIVTCDNGIAAAAEIQMAKDKGMTVIITD
                     HHEVPYREEKGERQMVLPPADAILNPKQYDCPYPNKNLCGAVVAFKYIAALYERFGVPA
                     EELEDYYELAAIATVGDVMDLQGENRILVKEGLCRLKNTKNQGLQELIRANSLEDAKIT
                     AYHIGFVLGPCINASGRLDTAARSLALLNAKTKEEAARLAGDLTALNQSRKALTEKGKE
                     EAIRIIETTELKNDRVLVVYLPDCHESLAGIIAGRIREKYHRPAFVLTGGETSTKGSGR
                     SIESYSMYEELVKCADLMIQFGGHPMAAGLSIEEKNIEEFRRRLNVNCTLTDEELRPKI
                     VIDVPMPVSYITKELVEQISLLEPFGKGNTKPVFAQKNLRVLDHSIIGKNKNVVKLKLL
                     DPQGISVEGIYFGEAEDFVNFIREKDSISVTYYPEINRFRGRESLQIIIQNYC"
     CDS             16051..16575
                     /locus_tag="ctg49_27"
                     /transl_table=11
                     /translation="MKKIEDYVLSIPDFPEPGIIFRDITSVLQDADGLQLAIDSMQDCL
                     KDIDVDVIAGTESRGFIFGVPIAYNLHKPFVPIRKKGKLPRETVSVSYDLEYGSAEIEM
                     HKDSIKPGQKVVIVDDLIATGGTIEAAIKLVEQLGGEVVKVVFLMELAGLKGRERLNGY
                     DVASVICYDGK"
     CDS             16613..18943
                     /locus_tag="ctg49_28"
                     /transl_table=11
                     /translation="MTEITKSTEAKKDEMQVEKEKLESVKRADAAVKTMHDFTSPEVLY
                     KELINSVLKYHPSTDISMIEKAYKVASEAHEGQKRKSGEPYIIHPLCVAIILADLELDK
                     ETIVAGLLHDAVEDTWMTYEEVEKEFGSEVALLVDGVTKLGQLSYSADKVEVQAENLRK
                     MFLAMAKDIRVILIKLADRLHNMRTLQYMRPEKQQEKARETMDIYAPIAMRLGISKIKV
                     ELDDLSLKYLKPDVYYDLVHKVALRKSEREQFVGAIVKEVKKHMDDANIKAQVDGRVKH
                     FFSIYKKMVNQDKTIDQIYDLFAVRILVDTVKDCYAALGVIHEMYKPIPGRFKDYIAMP
                     KPNMYQSLHTTLIGPNGQPFEIQIRTYEMHRTAEYGIAAHWKYKESSDGKAPVGKSEEE
                     KLNWLRQILEWQRDMSDNKEFMSLLKNDLDLFADSVYCFTPQGDVKTLPSGSTPVDFAY
                     SVHSAVGNKMVGARVNGKLVPIEYEIKNGDRIEIITSQNSQGPSRDWLKLVKSTQAKNK
                     INQWFKKELKEDNILKGKEMLAQYARAKGFKIANYTKTQYLEAVLRKYGFRDWDSVLAA
                     IGHGGLKEGQVFNKLVEAYDKENKKNLTDEQVLEAASETQEKLHIAKSKSGIVVKGIHD
                     VAVRFSKCCNPIPGDEIVGFVTRGRGITIHRTDCVNVLNMSETDRTRLIEAEWQQPDTK
                     EKEKYMAEIQVYANNRTGLLVDLSKIFTERKIDLRSINSRTSKQEKATISMSFEIGSKE
                     ELRSLIEKIRQVESVIDVERTTG"
     CDS             19008..19637
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1170:metallo-beta-lactamase family protein (Score:
                     161.3; E-value: 3.4e-49)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg49_29"
                     /transl_table=11
                     /translation="MKNLELQKCILGPVYTNCYLLKNKETGELIIVDPADCPEKIEMKI
                     SLMNGKPVAILLTHGHFDHILAAQAVKEKYNIPIYACRQEEEMLREPSINMTVHYGQGC
                     SIVPDVFLEDLDVIRLAGFSVQMIHTPGHTKGSCCYYLKDEGVLFSGDTVFYGSVGRTD
                     FPGGSTAEIVRSLHKLVDSLPEETEVFPGHDASTTIGYEKRYNPFV"
     CDS             19630..21144
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF04055"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg49_30"
                     /sec_met_domain="PF04055 (E-value: 2.3e-24, bitscore: 78.5,
                     seeds: 518, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MCKIGILFENRDFEHDVYELIKAFYPEAEIHTLYENAEAEYDLRF
                     SVEQDNDSYIIKYERTENLSKQETEQKGVISADILSKENAGCGIQDAHALRKENKDNIK
                     YALYQLLVKLTGRTLPWGNLTGIRPAKLAMGMIESGMKNTEAAREMRERYLVSPQKTAL
                     AITIANREREILKDIDYENGYSLYIGIPFCPSICLYCSFSSYPLKVWEKRTDEYVEALC
                     REVRETALMMKGRKLDTIYIGGGTPTTLLPHQIRKLLDTVGEAFGYEGLAEFTVEAGRP
                     DSITREKLMAIREYPVTRISVNPQTMNQETLDIIGRRHTVEQTKEAFHLARELGYDNIN
                     MDLIVGLPGEDIHMVERTLEQVRELAPDSITVHSLAVKRAARLNIFKEKYQEMSFENNQ
                     EIMDLTMKTAYEMGMGPYYLYRQKNMKGNFENVGYAKVDKAGIYNILIMEEKQPIIALG
                     AGGSSKLVFDHGQRIERVENVKDVSNYISRIDEMIERKRTAIATWL"
ORIGIN
        1 tggcagaatt catttttaaa gacatggttt ctaaacaagg tctttcagac cggttttata
       61 tcgcatctgc tgcaaccagc actgaggaga tatggaatgg aatcgggaat ccggtatatc
      121 ctccggcgcg agaggagctt gctaagcatg ggattgattg taagggtaag cgcgcagttc
      181 aactaacgaa ggcagattat gataaatatg attatattct cggtatggac cactggaatc
      241 tgaagaatat gttaagaata ttgaaatcag atccagagga caaggttaaa cttcttctgg
      301 attacagtga tgatccgagg gatatcgcag atccgtggta tacaggtgga tttgatgtca
      361 catattcgga tgtggtggag ggctgtgagg cttttctgga atatctgaaa gataaaaaga
      421 aactgtaata aatattgtcg atgaaattta ctttacaaat agctgtggct attttatact
      481 atgtctacag cgactcttaa gggggctttc gctcccttat tttctttttt ccgaaaacgg
      541 aaagtcaaca ttcaaatcag ggcatcctgc ccgtattatt ttcaaagcaa gaaaggaact
      601 gaatatgcag aaagactatg aaacattcgt agagaaactg gagattggta tttacgaggc
      661 tacagggatt ccgagggaaa atatttcttt tgagaaagaa ggcgggaggt ttgcacctgt
      721 aggagacaga ctgctggtga agtttgcaga gcatgatgat gcctgggagg tctgtggact
      781 ttatacacag gaacttttta aatcttatca gaatggcagt ccgtttgagg aaattataaa
      841 agaaatcaca gatgatctca atcggataaa aaaggcggat atttatgaga aaacaagagt
      901 gatcagggat tatgagaaga caaaaccccg cctgtttata agattgctga atgcagataa
      961 atattccgcg gatcttcagg atgcggtgta taaaactctt ggtgatattg cacttgtgct
     1021 ttatatgaaa gttacggaat atgaaggatg tgcgacaagt acaaaaatcc ggcagggaat
     1081 gctggagcag tggggaaaag aatgtgatga ggtgtttcag gaggcgattc tcaatacgta
     1141 ttttatgagt ccacccagaa tttacagatg ggaacagatg atttttaatc cggaatatga
     1201 aggtgaaagt tttatgaatc tgggtgataa gtgtgaattg aagaaagatg caatgggaaa
     1261 ttgtctcagt acaacgaaga aaacaaatgg tgcagttgca gtgttcctgc cgggagtggc
     1321 agaacaattg gcatatatgc tggattccga tttctatatg gtgtttacca gtgtacatga
     1381 ggtaatgatc cataatgata aatttgtaga acctgaagat ttgcagtgtg ttttgcggga
     1441 tacgatcagg gaggctacac cgaaagagga ctatctgacg tcgagaatct accagtacaa
     1501 tagggaaaca cataaattta tctgtgtaac tccgctggaa aaagatgaga aataaaaata
     1561 tgagagtact ccataaaaaa gtactctcat ataaaggata tttagaaacg ttatgagtaa
     1621 tttatacggt tatccgagca gtgcagagtc attactgaac tcttctccgc ttgctttttc
     1681 aaactgatcc agaaggtttt taactgtcag ttttttcttt tcttctccct ggatatccag
     1741 aatgattttt ccttccatca tcatgatcag acgattgcca tgtgcaatag cgtccttcat
     1801 gttgtgggtg atcatcaatg tcgtaaggtg atcgcggttt acgatcatat ctgtaatttc
     1861 cagaactttg gcagctgttt tcggatcaag agctgcggta tgttcatcca gaagcagaag
     1921 ctttggtttc tgaagcgttg ccatcagaag agtaagagcc tgtctctgac cacccgagag
     1981 aagtcctact ttagaagtca gtctgtcttc cagaccaaga ccaagaattt tcaggagctc
     2041 tttgtattct tcgcgctcag ctttagtgat tccggagcgg agaagacggg attttccgcg
     2101 gcgttttgca agtgcaaggt tttcctcgat acccattgtt gcagcggttc ctgtcattgg
     2161 atcctgaaac acacgtccaa ggtatgtagc acgtttatgt tcagaaagtt ttgtaacatc
     2221 aatattgtcg ataaggatct gtccttcatc aaccggccag gttcctgcaa cagcatttag
     2281 catagtagat ttgccggcgc cgtttcctcc gataacagtt acaaaatcgc cttcgttcag
     2341 cttcaggttc agaccattta atgcacgttt ctcattaatg gttccgggat taaaggtttt
     2401 atagatattt ttaagttcaa gcatttttat ttacctcccc ttttggctgg tttattaaag
     2461 tatttgcctt tccagtatgg gaatgcaagg aagagagcaa ctacgattgc ggacagcatc
     2521 ttcagcaggt cagtgtcgat acccatccag ataacaatct gaagtaccag ataatacaga
     2581 atggaaccga agataactgc taacaggcga agggcaaagt tgcggaaaat acgtccaaag
     2641 attgcctcgc caataataac tgctgccaga ccgataacga tggaaccacg tcccatgttg
     2701 acatctgcaa atccctgata ctgtgcaagg agtgcactgg aaagtcctac cagaccgttg
     2761 gaaatcataa gtccgagaac tttattcctg tttgtgttga taccctgggc gcgtgacata
     2821 tttgggttac atccggttgc gcgaagggaa cagccaagct ctgttccaaa aaaccagtag
     2881 agaatggcaa tcaggagaat acacataact gctacaataa aaattgtgtt tttggaaaga
     2941 gatgcatttt ttatatgtcg cagggaaacc agaagattat atttatcaac gttgattgcc
     3001 tgatttgctt ttcccatgat cttcaggttt acggaataca gagataactg tgtcaggatt
     3061 ccggcaagga ttgcgggaat tcccataaag gtgtgaaaaa ttccggtcgc aaggcctgcc
     3121 agcattccgg cgagagtagc ggccaacata gaaatccaga cattatgacc ggaaagcatc
     3181 atcataatac acactgcacc accggtgcac atagtgccat caactgtaag gtctgcaata
     3241 tcaagaatac ggaaagtgat ataaacaccg attgccataa ttccccagat cagaccctgg
     3301 gctactgcac ccggaagtgc agtgattaat gttataattt gcatttgtaa tttcctcctg
     3361 ttgagatgcg aaaagcgaga gaggcgtcaa acctttcccg ctgatcgcat ataaattgaa
     3421 ttttttataa ctgtttgata ggctgttatt taaaatcctg ttggtgtgag tatttttcaa
     3481 ctgtctgacc ggatttattt ggcagtttct tcagcagcct cgccgattgc aacataatcg
     3541 tccggaactt cgatgcccag ctcttcgcag atatctttgt tatattcttt tgtgaagttt
     3601 ggtgcatatt cgatcggcat tgtggaaata tcttcaccgt cctttaaaat cttaacagcc
     3661 atcttaccgg ttgtaacacc aaggtcataa tagctgatgg aaagtgtcgc aacaccgcat
     3721 ccgctgcaga taccttcttc gcctgtgatt accggaactt ttgccggaag gcagatgttg
     3781 ttgatgatct ctgtgttgga agcaactgta ttatctgtcg gtacataaat tacatcactt
     3841 gcgtcagttg ctgttgtagc aacagaagag agatcattag agtcagagaa tgcataatat
     3901 tcacatgtat atccgagttt ttcaagttca gcttttactg tatctacctg atactgagag
     3961 tttgcttcgg cagaacagta gagaagacct acattttttg catctgggaa aagttcattg
     4021 agcattgctg cctgctgatc aaggggagca aggtctgcag ttccggaaat atttccgccc
     4081 acagtcccgt cgaaatcatc cagtccaagt gcaacaccgt attcagtaac agaagtacca
     4141 agaatcggaa tatcgcttgt ccctgctgca gctgcctgaa gagcaggagt tgcatttgca
     4201 agaatcagat caacattatt ggaaacgaag ctgttaatga ttgtagaaca ggtgttggaa
     4261 tctccctgtg cgttctgctc gtcaaaggta actgcgtctt ctcccagttc tttggtgact
     4321 tcatccttga atccctgtgt cgcagcgtcg agagcttcgt gctgtacaag ctgacagata
     4381 ccgattgtat atttgtctcc gtcagcagca cttgccgtta ctgcgcaggt tcccatagcc
     4441 atggctgctg caagagtgat tgctaatgct tttcttttca taatgatata tcctcctaat
     4501 ataatgttta aattaagtca ggtaagaatt gcgtttatta tttgataata taaaacttac
     4561 ctgaatccga atgattttct gcagggaaag cagtactggt aaatgattcg gataatgtca
     4621 tcgagttatt cgactgtgac gttttaaagt ataacgcttt agtgtaaaaa agtcaagcga
     4681 cctgcacaat tatattttta attcatatag tataaagagt atatgaagaa agcagagtgt
     4741 cgtcatggca tattcgatca tgctggatgc cggacatgga ggtcaggatc cgggagccgt
     4801 atataaggga agacaggaaa agaatgacaa tcttaaactt gctcttgcgg taggtgagat
     4861 tttaaaaaat aaagggattg acatctctta tacccgtacc ggtgatgtct atcagacacc
     4921 ttttgagaag gcacagcttg caaatcaggc aggagtagat tactttattt catttcaccg
     4981 aaacagcagt ccaaaggaaa atcagtataa tggagcggaa gttctgattt atgataaaag
     5041 cgggattaaa tatcagatgg ctgagaatat tctgggagct ctgggagaag tgggattccg
     5101 cgaaatcggt gtaaaagagc ggccgggact tgtggtcctc agacgaacca ggatgccggc
     5161 tcttttaata gaaaccggat ttatcaattc cgaagaagat aataaactgt ttgataacaa
     5221 gtttagcgat atagctcagg gaattgcaga tgcgattctt ggaagcctgg atgaggaaac
     5281 agtgcaggaa ccgctttatt acagagtgca gactggagcg ttcagaaaaa aagagaatgc
     5341 ggaccgtatg ttatatcagt tactggaaaa aggttatccc tcttttatgt tacatgaaaa
     5401 cggattgtat aaagttcaga caggtgccta tcagcagatt ggtaatgcag taaatatgga
     5461 gcagagactg agggatgatg gttacagtac ggttattgtg acaaaatagc cttctggaaa
     5521 tattggaagt ctgtgcatcg cgaagcgtgt tgctgtgaac agagtgaaca gtaacataag
     5581 cagtggggga catagtttta agaattaact tggttgtacg ttaatagaaa aaatatggta
     5641 cactgtatct atctatagaa attccataga aatcttcgta aataatgcat attgttccgg
     5701 ttcatcagag cgtgaatttt tgttggactg ttacaaacgc attatttgag aggtgctgta
     5761 gaaaaaacag ataacgagga gttagtaatg atgaatgacg tatatgaaaa atttttaaaa
     5821 agttcagaag agtttatttt tgcagaaaac aagccggaaa aatctgatat tatttttgtc
     5881 cctggaaatg gttatccgca gatggcggaa aaagcagcag aattgtttaa gaaagggatg
     5941 gcggactgga ttctgcccag tggaaaatac agtgtagtaa atggaaagtt ttcaggcgtt
     6001 cttgaaaaaa gcaatgtata tgataaggaa tatggaacag aatgggaatt tctcagggat
     6061 gttcttataa aaaacggagt tccggatcag aaaatcctga aagaagacca ggcaaccttt
     6121 acttatgaga acgcaattta ttccagacag gtgacagatc atgcagaact ggaaatagaa
     6181 agagcgattt tgtgctgcaa atcttaccat gcaagaagat gtctgatgta ttatcagctc
     6241 ttgtatccga aaacagaatt ttatgtggtg cctgtgaatg cagatggaat taccagagaa
     6301 aactggaaaa agaacgaaga aggaattgat gcggttacag gagaactctc cagaatcgtg
     6361 aaacaatttt cactgatgct ggagagatga cagttacggc tgttcttctg tttcagtttt
     6421 cttctcggga agccagatgt ggacaagttc gattctgttt ttgtccagac ggtcaacaac
     6481 caggcggatg ccactttcaa gtgtgacaga ctgaccctct ttgggaaggc agtcaagctg
     6541 ttcaataata tatccgccaa tagaatcata atcttcagat tccagattaa tatggagggc
     6601 ttcgttgata tcatccagct tggcagaacc ctgaacaaca tattctcttt caggctggat
     6661 ttctttaata tcttcgactt catcctcatc gtattcgtcg cgaatctcac ctacgatctc
     6721 ttccaacagg tcttccaatg tgaccagacc cgctgtggca ccgtattcgt ccagaacgat
     6781 tgccagattg acggatgctt tacgcatttc aatcatcagg tctgctgtag ctttgtattc
     6841 ataggtaaaa taaggctcac gcaggatgtt gcggattgaa aaaggtttgt cctttggata
     6901 aacaagaaga tctttcatat tgataatacc gattacgtta tcagtgttgt cctcataaac
     6961 cggaaaacgg gtatgcatat cttcactgaa gaccgccata agttcatcat aggaaaaatt
     7021 gatatctata aaggtcatgt cgattctggg aatcatgaca tcttttgcag ttgaatcgcc
     7081 aaaatcaaac acattgtaga tcatctgttt ttcttcgttt tcaatgacgc cgtctttttc
     7141 acctacattg acgagggtac gcagttcatg ttcagtcatg gcatttgcct tttcgtccgg
     7201 gttaacatgc agaatgacca gtacaccttc tgttatttta tttacaatga aaacaacggg
     7261 agtaaggaga atcataagcc cgtatattat tcttgaatag gccagggaca atttttcagc
     7321 atgaattgtt gccaggtttt tgggggttat ctcaccgaaa atgagaatca gcagagtcag
     7381 gatgccggtt gtgattccta catatgcgtt tcccagaatc tttatggtga gtgtagtcat
     7441 gagagaagaa acagacatat ttacaatgtt gtttccgatt aatacggtac tgagcatctt
     7501 tggggaattg gaaattattt tttccagaat aacagcacgt ttgttgccct gctcggcaag
     7561 agactgtatc cgaatcttat ttacggttgt catagcggtt tccgcagaag aaaaaaatga
     7621 agaaagtgcg atcagtatca gaatcgccac cgcctgaaag gcaatacttg aatccaagat
     7681 ttattcactc cttttgatta tctttattga ttgaatcata tcataaaaca tttaagcaaa
     7741 atatacatga tttcatataa aaaatcaaga aaaagctttt ggttcaaaga tagtataaaa
     7801 aaatttaaaa gaggactgtc gaaaaagtaa gatttgtgtt ataattcact cgattaaaat
     7861 gaaaaaaaac attacagaat atttacaaaa tgataaaagt ttgataatat acagatatgt
     7921 aatattattg tattacgtaa aaagagaact gatatttggc tgaaagtaaa aaaatgatta
     7981 tcaggaaaca taagaatcga atataaatat agaggtgcga tatgtccaat aatataagaa
     8041 taagaaaaaa taaattaaaa ggaacgggta ttttggcggc agcggcttta acagcggctt
     8101 tgattgcagg aaataatata ccgggtgtaa caagacaggt cagtgcggct gagtcacagg
     8161 agaatactgt gtcttctctg atcccggaca acattacgct tgataagcct gtagaacttg
     8221 cggatgtaga acttccggca acggaatatg gaacttttga atgggcagat ggaagtttcg
     8281 ttcctgcaca gcgtgtacag agctgtgagg tacttcttat accggcagaa gggcaggatt
     8341 taagccatgt ggatggatgg gatccggaga gcggcgcggt tgtcggttac atcaatgtaa
     8401 tagtgaacag tattacggat agtgataatg ttgataagac agaaggctca ggtaaaacag
     8461 atccaacaga aaatgcagat ccaacagaaa cgcctgaaac ttcgtcagaa aaacctgccg
     8521 cagatgaaaa cgctgataca gacaataaag aagataagga aagtaaatca gatcaggata
     8581 ataaaactga tacagacaat gaagagaata agattgaaga agataaaaca gataataaaa
     8641 acaacaaaga taataacagc aatgcagata agacggataa agatacagaa actaccggta
     8701 agctggaacc tgcagatgat atgacacagg ataaagaaga tacgaagaaa gatgatgaag
     8761 atggcgcagg tgataatatc tttgataatc ctgttctgcc ggacgataag gatgaccgtc
     8821 ctacagatgc agaggattct ctttctgatg aagaaaaaga agagagggcc gcacttaatc
     8881 atacctgcga cggtattaca gtaagcggag ttaatcttcc atggtatgta cagttcagag
     8941 tttcaagcgg tgacagctat cagtttacca atgaatcaga tgcaatgatt ttccagtctt
     9001 atgaatttga actctgggat cttaagaata atacagaata cgagatccct aatggagatt
     9061 atatcagtgt cactgtgccg gtaaaatccg gatatcagta tactatcgaa catctcctgg
     9121 ataacggggc aactgagacg attattccga gtgtagagaa tggtattatg gtattcagca
     9181 cacattcttt cagtccattt ggaattgcag gaagcagaca attagtagga cctgatgcgg
     9241 ggaatgatac ggacgacaca gatgcggtaa ctcctgcacc ggcttcctcc gacagtcaga
     9301 gctctgattc cggaaagaac aatacagtat ctgtgaatga cagttctgac agcaataatg
     9361 gttcttcttc tgatcagaat gataattcaa cggaaaataa agctgtgaaa aataacaata
     9421 cagtaaatac cggagataca acatcaatta tgccgtttgt gatactgttt gtggcagctg
     9481 cagtgatcgc cggtgtggct gtatttataa aaaagagaaa gaaataaaag aataacactg
     9541 attcctcccc catatagttt aacaggaggg gaagcaatga aagtcagagc aattttgaaa
     9601 tcactattat ttgcatatgc attaacagga gtggcattac tgcttttggc cctggtactg
     9661 tttgcttttg atctgggaga aacagctgta gatgcgggta ttattataat ttatgtactt
     9721 gcatgtttca tgggaggctt tatggccggc aaaattgtgc gtaaagacaa atatctgtgg
     9781 ggtgttatca caggtctggc ttactatgta ttactgttga ctgtctctgt tatggcaaaa
     9841 ggcggctggg atatgagtgc agctcatgca gttacaacat tttttatgtg cacaggcggt
     9901 ggaacactgg gtggaatgct gtcgtaaaaa aaagctttta aaatgaaaag atatatgata
     9961 tactatgcca agaatataat tacataagga ggatagagtt atggaacata tcaaaaccct
    10021 gaatacaaag aatttacaga acactgtaaa aaaaggtgga tgtggcgagt gccagacttc
    10081 ctgccagtcc gcatgtaaaa cttcctgtac agtaggaaac cagagctgcg agcagaaata
    10141 agatcagcta tggagaaatg agataagcag cggaactttt attccgctgc ttatcttacg
    10201 cttagaaagg attttagtaa aatgagtctg attcaccgtt ataaaagcaa tggctttaat
    10261 attgtactgg atatcaacag tggatgcatc catctggtag atgaggttac atatgaggtc
    10321 cttccatatc tggaagaggg ccttggcaca gaagctattg cagagaaact ggaaaacaaa
    10381 tataacagag aagatattga gacatctgta agagaatgta ataagctgaa agaagatgga
    10441 atgcttttta caaaagatgt ttatgagaat gtaattgaag aattttcaaa taaccggcag
    10501 accgttgtaa aagcattgtg cctgcacatt gctcatgact gcaatctggc ctgccgttat
    10561 tgttttgccg aagaaggcga atatcatggc agaagagctc ttatgtctta tgaagtcggc
    10621 aaaaaagctc ttgatttcct gatcgcgaac tccggttcca ggaaaaacct ggaagtagat
    10681 ttctttggcg gcgagccgct gatgaactgg caggttgtaa aagatctggt aaaatatggc
    10741 agagagcagg aaaagcttca caataagaaa ttccgtttca ctttaacaac aaacggagtt
    10801 cttctgaatg atgaagtaat ggaattctgc aataaagaga tgggcaacgt tgtactgagt
    10861 gtggacggac gtaaggaagt acatgattac atgcgtccat tcagaaaagg tgcaggaagc
    10921 tatgacctga tcatgccgaa gttccagaag tttgcagaat ccagaaatca ggacaagtat
    10981 tatgtaagag gtacttttac ccaccataat cttgatttct ccaaggatgt gcttcatctg
    11041 gcagatcttg gattcaaaca gatttctgta gagcctgtag ttgcggctga tacggaggaa
    11101 tatgcgatcc gcgaggagga tatcccccag atcatggaag agtatgatac tcttgcaaaa
    11161 gaaatgatta aaagagagaa agagggaaaa ggatttaact tcttccattt tatgatcgac
    11221 cttacaggtg gcccttgtgt atacaagaga ctgtcaggct gcggttcagg aacagagtac
    11281 ctggctgtaa caccctgggg tgatttttac ccatgtcacc agtttgttgg tgaagaacag
    11341 tatctcatgg gaaatgtaga cgaaggcatc acaaagccgg aaatccagaa ggaattcggc
    11401 ggatgcaacg tttacacaaa gaaagactgc aaagactgct tcgcacgttt ctactgtagt
    11461 ggcggatgtg cggcaaatgc attccatttc cagggagata tcaaaggcaa ttatgaaatc
    11521 ggatgcgaac tccagagaaa acgtgtggag tgcgccatca tgataaaagc cgcactggca
    11581 tgtgattagt gggcagtaat ctgtctgact gataccgccg tcggctgtta tcataacaga
    11641 aaatggctgg caggcggatg aacatgaccg cggacaaaaa atcaagaagg gaaaagaaat
    11701 atgaagaaaa gtaaaggaat cgtagtgctg cttctgacac tgatcctgac tgtgttcttt
    11761 tgctttactg cagccgtagg tatcggtcct accggaaccg gtgcagcaaa acatatcaac
    11821 acgggtcttg atcttgccgg tggtgtcagc attacctacc aggctaagga gagcaatccg
    11881 acaagcgaag agatgtcaga tacgatctac aagcttcaga agcgtgtaga gcagtacagt
    11941 actgaggctc aggtatacca ggaaggatca gaccgtatta cagttgaaat tcctggtgtt
    12001 acagatgcag atactatttt gaatgatctg ggtaaaccag gttccctgta tttcatcaca
    12061 aaagaagatg ccgacggaaa ccagaacttt actacaggac aggatggata tgttctctcc
    12121 agaactatgg atgagatcaa ggaatccgga agtgttgttc tggaaggttc tgatgtagca
    12181 gatgcccagg gtggtgcgat ccagaatcag aacacaagtg caaaggaata tgtggtaagt
    12241 cttactctta cttctgatgg agaaaacagt ggtaaaacaa aatttgcaga agctacaaag
    12301 aataatgtag gcaagcagat cgctatcgtc tatgacaata acattatcag tgctccgaat
    12361 gtaaatgaag agatttccgg cggaaaagca cagatcagcg gaatgtctga cctggaagaa
    12421 gcacagaacc ttgcttctta tatccgtatc ggttctctgg gactggaact ggaagaactt
    12481 cgttccagtg ttgtagctgc acagcttggt gaagaagcaa tctctacaag tgttcttgca
    12541 ggtgcgatcg gtctgatcat cgttattatc tttatgatca ttgcataccg cgtacctggt
    12601 gtagttgcag gtatcgcact gattctttat acatcattaa tgctgatcac gctgaatgcc
    12661 tttgatatta ctcttactct tccgggtatt gcgggtatta ttcttggtat cggtatggcg
    12721 gtggatgcca atgttattat ttatgcccga atcagagagg aaattggtgc aggagtttca
    12781 gtaaggaatt ctattaagtc cggtttcagc aaagctttct ctgcaatctt tgatggaaat
    12841 attacaacac tgatcgcagc ctttgtgctg atgtggcttg gttcaggtac tgttaaggga
    12901 tttgcttata cacttgccct tggtatcgtg atctccatgt ttacagcact ggttgtatcc
    12961 agactgattg taaatgcact ttatgcagtt ggtgtacgtg atccgaaatt ctacggatct
    13021 gcaaaagaac gtaaggcagt tgatttcctt ggaaagaaga aagtattttt tgctatttcc
    13081 attatcctga tcctctgcgg tccggcagcg atgtttgcta attcgcatgc aggaaacaaa
    13141 gcgttaaatt acagccttga gttctcaggc ggtacttcta cgactgttac atttaatgaa
    13201 gatatggata ttaagaccat tgattctgaa gtaactcctg ttgtagaaga ggtgacagga
    13261 gataaaaatg ttcagcctac aaaggtagtc ggaacaaatc aggttgtgat caagacacgt
    13321 tctctgaatc agagcgaacg tgaagctctg cagagtgcac tggttgagaa atttggtgta
    13381 gatgacagca cgatttccac agaaagtatt tcttctacag taagtagtga aatgcgtcgt
    13441 gatgcgatcg tagccgttat agtagctaca atctgtatgc ttctttatat ctggttcaga
    13501 tttaaagaca tccgttttgc aagcagtgcg gtattggcgc ttctgcatga tgttctggtt
    13561 gtacttgcat tctatgctat tgccagagta tctgtcggta atacatttat tgcctgcatg
    13621 cttacaatcg taggttattc tatcaatgct acaatcgtta tttttgaccg tatacgtgag
    13681 aaccttcaca gtggttccag agaaaaactg gcagaaattg taaacacaag tatcactcag
    13741 actcttacaa gaagtattta tacctctttt acaacttttg ttatggtagc tgttctttat
    13801 atcatgggtg tttcttctat ccgtgaattt gcagcacctc tgatggttgg tgttcttgtc
    13861 ggtgcatatt cttctgtatg tattacaggt gcgttgtggt atgtgatgaa aaagaaattt
    13921 gcaggaaaag gacagccggc aattgctgca gcttccgcat ctgcaaagtc ctcttcaaag
    13981 ccgaagaaag cacgtgatgt atcacagaaa gatccgactc agccaaagaa gaaaaacaga
    14041 aaaagagtag ctgaacgtct ggctgccgaa gaagcagcta aaaaacagca gaatgatgat
    14101 gctgaataaa acaataattg tctgaaaaac aggcagacag aaatatcccg gggtaaaact
    14161 ccgggatatt tttatgagga gagaaaatat atggagaaat gggtaatagc agcaaaaaga
    14221 gcagatttta accagatcgg tcaacagttt catattgatc cggtgattgc gagactgatc
    14281 aggaacagag atgtgatcgg agaagataag ataagagagt atctgtcagg aacagtacaa
    14341 gagcttcctt ctccctggct gatgaaggat atggaaaaag ctgtagatat cctggagaaa
    14401 aaaatatcgc agaaagcaaa agtccgtatt attggtgatt atgatattga tggtgtgacc
    14461 tctacataca ttttaatgaa aggccttgcg aggatcggag cagatgtgga tacttatatt
    14521 ccggacagag ttgcagacgg atatgggatt catgcacatc ttatagaaag agcggaaacg
    14581 gaccggatcg atacgatcgt gacctgtgat aatggaattg ctgcggctgc tgaaatccag
    14641 atggcaaagg ataagggaat gacagtgatt attacagatc atcatgaggt tccttacagg
    14701 gaggaaaagg gagaacgcca gatggtgctt ccgccggcag atgcgatttt gaatccgaaa
    14761 caatatgatt gtccataccc gaataaaaac ctgtgtgggg cagtggtggc ctttaaatat
    14821 attgcagcac tttacgagag atttggtgtt ccggcagagg agctggaaga ttattatgaa
    14881 ctggcggcta ttgcaacagt aggagatgtt atggatcttc agggagagaa caggattctg
    14941 gtaaaagaag ggctgtgccg tctgaaaaat accaaaaatc aaggattgca ggaactgatc
    15001 cgagcaaatt ctctggaaga tgctaaaatc acagcttatc atatcggatt tgtgctggga
    15061 ccatgtatca atgccagtgg cagactggat acagctgccc gttctcttgc acttctcaat
    15121 gcaaaaacaa aggaagaagc agcaaggctt gccggagatc ttacagctct taatcagagc
    15181 cgaaaagctc tcactgagaa aggaaaagaa gaggcaatcc ggatcataga gactacagag
    15241 ctgaaaaatg acagagtact ggtagtttat cttccagatt gtcatgaaag tcttgccggt
    15301 attatagcag gcaggatcag ggaaaaatat cacaggcctg cctttgtatt gacgggcggt
    15361 gagacaagta caaaaggaag cggaagatca atagaaagtt actctatgta tgaagaactg
    15421 gtaaaatgtg cagacctgat gatacagttt ggaggtcatc cgatggctgc aggtctttct
    15481 atagaagaaa aaaatataga agaattccgg agacgtctca atgtaaactg tacgttgacg
    15541 gacgaagaat tgcgtcctaa gatcgtgatt gacgtgccga tgcctgtgtc ttatattaca
    15601 aaagaactgg tagaacagat ttcgcttttg gagccctttg gaaaagggaa tacaaaaccg
    15661 gtctttgcgc agaaaaatct cagagtgctt gatcacagta ttatcgggaa aaataaaaat
    15721 gtagtaaaat taaaacttct cgatccgcag gggatttcag tggaaggcat ttatttcgga
    15781 gaagcagagg attttgtgaa ctttatcagg gaaaaagaca gtatttctgt tacttattat
    15841 ccggagatca acagattcag gggacgagag agtcttcaga tcattattca gaattactgt
    15901 taatattacc gcttggtttg taaccgccgg taagcctgga aatacaaatg tcagggctta
    15961 acagtaactt gattctgaaa taaaaaggtg atatactata aaatatttat gagcgaacag
    16021 caatataaca cacactggag gagaaataaa atgaagaaaa ttgaagatta tgtattaagt
    16081 ataccggatt ttcctgaacc ggggattatt ttcagagata ttacaagtgt tctgcaggat
    16141 gcggatggcc tgcagttggc catcgactcc atgcaggact gccttaagga tatagatgtg
    16201 gacgtgattg caggaacaga gtccagaggc tttatctttg gtgtaccgat cgcatataat
    16261 cttcataaac catttgtacc gattcgtaaa aaaggcaaac ttccccgcga aacagtatct
    16321 gtaagctatg atctggaata tggcagtgca gagattgaaa tgcataaaga ttccataaaa
    16381 ccaggtcaga aagtggttat cgttgatgat ctgatcgcaa caggcggtac gatcgaagca
    16441 gcgatcaagc tggtggaaca gcttggcggt gaggttgtca aggttgtatt tctcatggaa
    16501 cttgcaggtt taaagggacg cgaaagactg aatgggtatg atgtagcgtc cgtaatttgt
    16561 tatgatggta aataggcaca gctgattgtg caggacaggc aggtgggagc atatgacaga
    16621 gataacaaaa agtacagaag caaaaaaaga tgaaatgcag gttgaaaaag agaagctgga
    16681 atctgtaaag agagcagatg cggcagtaaa gaccatgcat gattttacaa gtccggaggt
    16741 gctttataaa gaactgataa acagtgttct gaagtatcat ccatcaacag atatttccat
    16801 gatagagaag gcatataagg ttgcaagtga agctcatgaa ggacagaaga gaaagtctgg
    16861 agagccatat atcattcatc ctttgtgtgt tgccatcatt ctggcagatc tggaacttga
    16921 caaagaaaca atagttgcag gtcttcttca tgatgcagtt gaagatacct ggatgaccta
    16981 tgaggaagtg gagaaggaat ttggttcaga ggttgcactt cttgtggatg gtgttaccaa
    17041 gctgggacag ttatcttatt ctgcggataa agtagaagtt caggcagaga acctcagaaa
    17101 gatgtttctt gccatggcta aggatatcag agttattctg atcaagcttg cagaccgtct
    17161 tcataatatg cgtaccttac agtatatgcg tcctgaaaag cagcaggaaa aggccagaga
    17221 gaccatggat atttatgctc ctattgccat gcgtctgggt atttccaaga taaaggtaga
    17281 gctggatgac ctgtcgctga aataccttaa gccggatgta tattatgacc tggtgcataa
    17341 ggttgccctg cgtaaaagcg agagagaaca gtttgtaggt gcgattgtaa aagaagttaa
    17401 gaaacatatg gatgatgcca atattaaggc gcaggtggac ggacgtgtaa aacacttttt
    17461 cagcatctac aagaagatgg taaatcagga taagactatt gatcagattt atgatttatt
    17521 tgctgtccgt attcttgtag atacagtgaa ggattgttat gctgcccttg gtgtgatcca
    17581 tgagatgtat aagccaattc cgggacggtt taaagattat attgccatgc cgaaacccaa
    17641 tatgtatcag tcattgcata ccacattgat cggacccaac ggacagccct ttgaaatcca
    17701 gatccgtact tatgaaatgc acagaactgc agaatatggt atcgctgcac actggaaata
    17761 taaggagtcg tctgacggaa aggctcctgt aggtaagagt gaggaagaga aactgaactg
    17821 gctgcgtcag attctggaat ggcagagaga catgtctgat aacaaagaat tcatgagtct
    17881 tctgaagaat gacctggatc tttttgcgga cagtgtttac tgtttcactc cacagggaga
    17941 tgttaaaaca cttccaagcg gttctacacc ggtggatttt gcgtacagtg ttcacagtgc
    18001 agtcggaaat aagatggtag gtgccagagt taacggtaag ctggttccga ttgaatatga
    18061 gatcaaaaac ggcgaccgta ttgaaatcat tacttcacag aattctcagg gaccaagccg
    18121 cgactggctg aaactggtta agagtactca ggcaaagaac aagattaacc agtggttcaa
    18181 gaaggaatta aaagaagata atatccttaa gggcaaggag atgcttgcgc agtatgcgcg
    18241 tgcaaaggga tttaagatcg caaattatac aaaaacccag tatttggagg ctgttttgcg
    18301 taaatatggt ttcagggact gggattcagt acttgctgca attggtcatg gcggattgaa
    18361 agaaggtcag gttttcaata agctggtaga ggcttatgat aaggaaaata agaagaatct
    18421 gacagatgag caggttcttg aggctgcttc tgagacacag gagaagcttc acattgccaa
    18481 gagcaagagc ggcattgtgg taaaaggaat ccatgatgtg gcagtccgtt tttccaagtg
    18541 ctgtaatccg atcccgggtg acgagattgt aggctttgtt acaagaggac gtggaatcac
    18601 aatccatcgt acagattgcg tcaatgtgct gaatatgtct gagacggaca ggacacgact
    18661 gatcgaggcg gaatggcagc agcctgatac caaggaaaaa gagaagtata tggctgagat
    18721 tcaggtttat gcaaataacc gtacagggct tcttgtggat ctttctaaaa tatttacaga
    18781 acgtaagatc gacctgcgaa gtatcaacag ccgtacaagc aagcaggaga aggcaactat
    18841 ttccatgagt tttgagattg gaagcaaaga ggaactgcgt tccctgatcg agaagatccg
    18901 tcaggtagag agtgtcattg acgtagagag aactacaggc tgatcatgga aaaatctgct
    18961 ggaacattat tttatggaac tgctgcagat tgacagaaag gaataacatg aagaatttag
    19021 aattacagaa atgtatatta ggacctgtat atacaaattg ctatctcctt aagaataaag
    19081 aaaccggaga actgatcatt gttgatcccg cagattgtcc ggagaagatt gaaatgaaga
    19141 tttccctgat gaatggaaaa ccggtggcga ttcttcttac ccatggacat tttgaccaca
    19201 ttctggctgc acaggcagta aaggagaaat ataatattcc gatttatgcc tgtcgtcagg
    19261 aagaggagat gctccgcgaa ccttcgatca atatgactgt acattatgga cagggatgtt
    19321 ctattgtgcc ggatgtattt ctggaggatc tggatgttat cagactggcg ggattttccg
    19381 ttcagatgat ccatacaccg ggacatacca aaggaagctg ctgttattat ctgaaagatg
    19441 aaggtgtatt gttcagcggt gatacagtgt tctatggctc tgttggaaga acggattttc
    19501 cgggtggaag tacagcagaa atcgtgagaa gtctccataa actggtagat tcgcttcctg
    19561 aagagaccga ggttttcccc ggacatgatg catctaccac tattggttat gaaaagaggt
    19621 ataatccatt tgtgtaaaat aggcattctg tttgagaaca gagattttga acatgatgtt
    19681 tatgaactga tcaaagcgtt ttatcccgaa gcggagatac atactcttta tgaaaatgct
    19741 gaagcagagt atgacctccg cttcagtgtg gaacaggata atgacagtta tatcataaaa
    19801 tacgaaagga cagagaatct gtcgaaacag gaaacagagc aaaaaggggt aatttccgca
    19861 gacatacttt ctaaagagaa tgcaggctgt ggaatacagg atgctcatgc tctgagaaaa
    19921 gagaataaag ataatatcaa atatgctctg tatcagttgt tggtaaaact gacgggcaga
    19981 actcttccat ggggaaatct gacaggaata cgtcctgcca aactggcaat gggaatgatc
    20041 gaatccggaa tgaaaaatac ggaagcagcc cgggagatgc gtgagagata tctggtgagt
    20101 ccgcagaaaa cagcgcttgc catcactatt gcaaacaggg aaagagagat tctgaaggat
    20161 attgactatg aaaatggata cagcctttat attggaatcc cgttttgccc aagtatctgt
    20221 ctgtattgtt ccttcagctc ctatccgctg aaagtgtggg agaagagaac agatgaatat
    20281 gtggaagctc tctgccggga ggtaagagag actgctctta tgatgaaggg aagaaaactg
    20341 gacaccatct atattggcgg cggtactccg actacactgc ttccacatca gatccgtaag
    20401 ctcctggata cagtgggaga agcttttggc tatgaaggac tggcagagtt tactgtggaa
    20461 gccggcagac cggacagtat tacacgtgaa aagctgatgg cgatcaggga gtatccggta
    20521 acaagaattt ccgtaaatcc acagactatg aatcaggaaa ccctggatat tatcggccgc
    20581 agacatactg tggagcagac aaaagaagcg tttcatctag cacgagagct gggatacgat
    20641 aacattaaca tggatctgat cgtaggtctt ccgggtgagg atattcacat ggtagagcgg
    20701 actcttgaac aggttcgtga actggcaccg gacagtatta ccgtacattc actggcagtg
    20761 aaacgtgcag caaggctgaa tatttttaaa gagaaatatc aggaaatgtc ttttgagaat
    20821 aatcaggaga ttatggatct gaccatgaaa accgcatatg aaatgggaat gggcccttat
    20881 tatctgtata gacagaagaa tatgaaggga aattttgaaa atgttggcta tgcaaaggtt
    20941 gacaaagcgg gaatttacaa tatactgatt atggaggaaa aacagcctat catcgcactg
    21001 ggggcaggcg gttcttccaa gctggtcttt gaccatggac agagaattga gcgtgtggag
    21061 aatgtaaaag acgtttctaa ttatatttcc cgcattgatg agatgatcga gagaaaacgg
    21121 acagcaatag ctacctggct gtaggatgtg gaggtaacat tttggacaca gtacaaaaga
    21181 cagcagcagg ttcacagcag aggattctgg aatttgacct tgcttctgaa ctgcatcatg
    21241 gaatgctggt aagtaatctg gcttatgcgg ttgcagagga gatgggactg ccgcatgaac
    21301 agtgctatga gcttgcaata gcaggaatgc tccatgatat aggaaagctg aagctgacaa
    21361 gttatattaa cggacaggag caggatcctc tggtgataga ggaactgaag tatgtccgga
    21421 tgcattctac attgggatat gaggaactta aagggcaggg atattcggat tttgtattgg
    21481 agagtatcct gtaccatcat gagaattatg atggcagtgg atatccgtcc aataaagcag
    21541 gtgatgacat acccataggt gcccggatac tcagagtctg cgatgtata
//
