LOCUS       c00043_gnlPro..        16527 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|FKHCHIMF_50.
ACCESSION   c00043_gnlPro..
VERSION     c00043_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-04 01:24:30
            Original ID  :: gnl|Prokka|FKHCHIMF_50
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 16527
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..16527
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[988:6527]"
                     /cutoff="10000"
                     /detection_rule="(TPP_enzyme_C and not (PFL-like or
                     PFL_6_pcresol or PFL_9_tma or Gly_radical or Gly_430_pcre
                     or Gly_8-9_TMA or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and
                     minimum(2, [ALS_ss_C, AlaDh_PNT_C, Arginase, BKACE,
                     BcrAD_BadFG, Beta_elim_lyase, CPSase_L_D2, Cys_Met_Meta_PP,
                     ELFV_dehydrog, GRDB, Glu_syn_central, Glu_synthase,
                     Gly_reductase, HAAA1, HG2B1, HG2B2, HGD-D, HleuD1, HleuD2,
                     HleuS1, HleuS2, Homoserine_dh, ILVD_EDD, IlvC,
                     Lactoyl-CoA1, Lactoyl-CoA2, Lyase_aromatic, MAAL_C,
                     OKR_DC_1_5_lysine, OKR_DC_1_5_ornithine,
                     OKR_DC_1_7_arginine, OKR_DC_1_C, OTCace, PALP,
                     Proline_reductase, Sacchrp_dh_C, TPL, Thr_dehydrat_C, TnaA,
                     Urocanase]) and not (POR or POR_N or PFOR_II))"
                     /neighbourhood="10000"
                     /product="TPP_AA_metabolism"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      989..6527
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(TPP_enzyme_C and not (PFL-like or
                     PFL_6_pcresol or PFL_9_tma or Gly_radical or Gly_430_pcre
                     or Gly_8-9_TMA or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and
                     minimum(2, [ALS_ss_C, AlaDh_PNT_C, Arginase, BKACE,
                     BcrAD_BadFG, Beta_elim_lyase, CPSase_L_D2, Cys_Met_Meta_PP,
                     ELFV_dehydrog, GRDB, Glu_syn_central, Glu_synthase,
                     Gly_reductase, HAAA1, HG2B1, HG2B2, HGD-D, HleuD1, HleuD2,
                     HleuS1, HleuS2, Homoserine_dh, ILVD_EDD, IlvC,
                     Lactoyl-CoA1, Lactoyl-CoA2, Lyase_aromatic, MAAL_C,
                     OKR_DC_1_5_lysine, OKR_DC_1_5_ornithine,
                     OKR_DC_1_7_arginine, OKR_DC_1_C, OTCace, PALP,
                     Proline_reductase, Sacchrp_dh_C, TPL, Thr_dehydrat_C, TnaA,
                     Urocanase]) and not (POR or POR_N or PFOR_II))"
                     /neighbourhood="10000"
                     /product="TPP_AA_metabolism"
                     /protocluster_number="1"
     cand_cluster    1..16527
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(TPP_enzyme_C and not (PFL-like or
                     PFL_6_pcresol or PFL_9_tma or Gly_radical or Gly_430_pcre
                     or Gly_8-9_TMA or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and
                     minimum(2, [ALS_ss_C, AlaDh_PNT_C, Arginase, BKACE,
                     BcrAD_BadFG, Beta_elim_lyase, CPSase_L_D2, Cys_Met_Meta_PP,
                     ELFV_dehydrog, GRDB, Glu_syn_central, Glu_synthase,
                     Gly_reductase, HAAA1, HG2B1, HG2B2, HGD-D, HleuD1, HleuD2,
                     HleuS1, HleuS2, Homoserine_dh, ILVD_EDD, IlvC,
                     Lactoyl-CoA1, Lactoyl-CoA2, Lyase_aromatic, MAAL_C,
                     OKR_DC_1_5_lysine, OKR_DC_1_5_ornithine,
                     OKR_DC_1_7_arginine, OKR_DC_1_C, OTCace, PALP,
                     Proline_reductase, Sacchrp_dh_C, TPL, Thr_dehydrat_C, TnaA,
                     Urocanase]) and not (POR or POR_N or PFOR_II))"
                     /kind="single"
                     /product="TPP_AA_metabolism"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..16527
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="TPP_AA_metabolism"
                     /region_number="1"
                     /rules="(TPP_enzyme_C and not (PFL-like or PFL_6_pcresol or
                     PFL_9_tma or Gly_radical or Gly_430_pcre or Gly_8-9_TMA or
                     PFL_acetate1 or PFL_acetate2 or Gly_radical_scatole or
                     PFL_proline or PFL_toluene) and minimum(2, [ALS_ss_C,
                     AlaDh_PNT_C, Arginase, BKACE, BcrAD_BadFG, Beta_elim_lyase,
                     CPSase_L_D2, Cys_Met_Meta_PP, ELFV_dehydrog, GRDB,
                     Glu_syn_central, Glu_synthase, Gly_reductase, HAAA1, HG2B1,
                     HG2B2, HGD-D, HleuD1, HleuD2, HleuS1, HleuS2,
                     Homoserine_dh, ILVD_EDD, IlvC, Lactoyl-CoA1, Lactoyl-CoA2,
                     Lyase_aromatic, MAAL_C, OKR_DC_1_5_lysine,
                     OKR_DC_1_5_ornithine, OKR_DC_1_7_arginine, OKR_DC_1_C,
                     OTCace, PALP, Proline_reductase, Sacchrp_dh_C, TPL,
                     Thr_dehydrat_C, TnaA, Urocanase]) and not (POR or POR_N or
                     PFOR_II))"
                     /tool="gutsmash"
     CDS             989..2707
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: TPP_enzyme_C"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg43_1"
                     /sec_met_domain="TPP_enzyme_C (E-value: 9.7e-49, bitscore:
                     157.0, seeds: 323, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKQISGNKLLVKALKEEGVEYLFGYPGACTIDISDELYKQDDVKI
                     ILPRHEQALVHEADAYARTTGKVGVCLVTSGPGATNLVTGLATANYDSVPLVCFTGQVA
                     RHLIGNDAFQEVDIVGITRSITKYGVTVRRREDLGRIIKEAFYIARTGRPGPVLIDLPK
                     DVMAELGSAEYPKNVNIRGYKPNTDVHIGQLKRAIKLLNKAKRPLFLAGGGVVISRAHE
                     IFREVVEKTKVPVVTTVMGKGSIPTDHPLYIGNLGMHGAYAANMAVSNCDVLFSIGTRF
                     NDRITGKLHEFAPHAQIIHIDIDTASISRNIQVDIPIVADAKEAITKMNEYVQECSTDK
                     WLNLIKNWKEEHPLKMRPNDLLSPMDILKEINEQFENSIIVTDVGQHQMLVSQYAEITE
                     GKQMIMSGGLGTMGYGLPGGIGAKIGNPDRPVIVISGDGGVQMNIQELATAVLEELPVI
                     LCIFNNEYLGMVRQWQKLFYGKRYAMTNLRAGALSRRTEGMEYPQYTPDFIKLAESYRA
                     KGIRVTKKEEIAAAFEEAKKNTKAPTVIEFIIDPEEMVYPMIKPGGTLEDMIMDC"
     CDS             2725..3234
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: ALS_ss_C"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg43_2"
                     /sec_met_domain="ALS_ss_C (E-value: 2.5e-22, bitscore:
                     70.9, seeds: 685, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDKGMKKRWISLYVENQVGVLSKISGLFSGKSYNLDSLTVGTTED
                     PTVSRMTIATVSDDETFEQIKKQLNRMIEVIKVIDFTDVFVRMKEILYIKVFNCSKEDK
                     VELFQIAETFKAKVIDYGKDSLLLEFVQTATKNDAVVKLIKEEFHRIEVVRGGSVGIES
                     ISMMER"
     CDS             complement(3303..4559)
                     /locus_tag="ctg43_3"
                     /transl_table=11
                     /translation="VKSTERLIFHIDVNSAFLSWESARRVSQGLPDLREIPSCVGGNPK
                     KRTGIVVAKSIPAKKYGIQTGEPVAMALRKCPNLVIVPSDFELYDKCSRAFKAICASFA
                     PVMESFSIDEVFLDMTGTSLIYPDPVAAAHELKDKIHRELGFTVNVGISTNKLLAKMAS
                     DFQKPDRVHTLFPDEIPEKMWPLPIRNLLFLGKASEQKLLNQGIRTIGDLARERASNVQ
                     YWLGEKTGHQLWQYARGIDDSPVKAVPDEAKGFSVETTFNDDITSIEQVFPILLEQCDV
                     LATRMRRKDKKCNCISVTFRTLDFRNRSHQTKLENATDLTDEIYINATRLFKEFWKGQP
                     LRLIGVALTGLTDGTYEQMSLFEDTENKERHRKLDAAMDEIRMKFGNDKITRASIMNSN
                     ARIGRKAKAQMKNEKTEEP"
     CDS             5322..6035
                     /locus_tag="ctg43_4"
                     /transl_table=11
                     /translation="MYLSDIHTHSIASGHGTTCTISDMAKAASKKGLKLLGISEHGPGT
                     LASGTSSYFRSLPFYPRKRFGIDILYGVELNILDSAGHTDLSDELLNNLDYAIISMHRQ
                     NYRSGSVSQNTEAYINAMKHPAVKILGHCDDTHFPVDYETLARAALRENVIFEINEASL
                     APGGYRGDTRANAARILYLCQRYQLPVILSSDSHGKEHVGDFTYAEEFVHQLMFPETLI
                     LNNQLPKLKVFLQTR"
     CDS             6237..6527
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: ALS_ss_C"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg43_5"
                     /sec_met_domain="ALS_ss_C (E-value: 1.4e-15, bitscore:
                     49.3, seeds: 685, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTIATVSDDETFEQSKKQLNRMIEVIKVIDFTDVFVRMKEILYIK
                     VFNCSREDKAELFQIAETFKAKVIDYGKDSLLLKFVQTATKNDAVVKLIKE"
     CDS             6972..7607
                     /locus_tag="ctg43_6"
                     /transl_table=11
                     /translation="MNTTTTTTTAATKRSSTLYMVELAMMIAIILLMSFTPLGYLRTPG
                     LSITLLTIPVAVGAIILGPKGGAVCGLAFGATSFYMAVTGSSAFAAALFNINPFGTFIV
                     CIVARVLEGWITGLIFAALYKSPAKKFSYYVASLACPLLNTFFFMGFLCLFFYNTDYIQ
                     GIVSSLGVSNPVVFVAAFVGVQGLIEAGFCFVVGSIVSKALSVALKRA"
     CDS             7732..8697
                     /locus_tag="ctg43_7"
                     /transl_table=11
                     /translation="MSLLKEISITDLSNLRIGHASDYNAQTGVTVLYFPLGAKVGCDIS
                     GGGPASRETPLTSPVTADNPINAIVLSGGSAYGLAAADGVMNYLESQNIGYNTGAALVP
                     LVCQSCIYDLSYGDPKIRPTAKMGEEACRQAFAGTDARTGNIGAGTGATVGKLYGMKQS
                     MKSGLGIAAVSVGNFQMAAIVVVNALGDIFSPQNGQKIAGLKTPDRSGFLDSVHELYRF
                     MTPHDQFTGNTTIGAVITNGAFSKAELNKIASMTRCAYARCINPVATMADGDSIYAASI
                     GDVSVDINMAGTLAAEVMAQAIQNAIHTSRIQDEEFLKYV"
     CDS             complement(9110..10294)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) MFS_1"
                     /gene_functions="transport (smcogs) SMCOG1058:Major
                     facilitator family (Score: 78.8; E-value: 1.2e-24)"
                     /gene_kind="transport"
                     /locus_tag="ctg43_8"
                     /sec_met_domain="MFS_1 (E-value: 1.1e-24, bitscore: 78.8,
                     seeds: 192, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKTNYNRTVQACFIGYVVQAIVNNFVPLLFLTFQGSYGISLQKIT
                     LLVTFNFGIQLLVDLASIGFVDRIGYRASMILAHAMAAAGLILLTVLPECLGNPFVGLL
                     IAVMIYAIGGGLLEVLVSPVVEACPTDNKEKAMSLLHSFYCWGHVGVVLLSTLFFRIFG
                     IANWKYMALVWALIPIANGIFFTRVPIAPLLDEGEKGLTMGELFKKKIFWVLMLMMLCA
                     GASEQAVSQWASTLAEKSFGINKTIGDLAGPMAFAILMGSSRAFYGKFGDKINLERFMQ
                     YSAVLCMVSYLMIAFIPVPALGILGCAVCGLSVGIMWPGTFSMAAASVKRGGTALFALL
                     ALAGDVGCSSGPTYVGMISGALNDNLKLGIFAALIFPVLMIMGIKMIGSLQKYD"
     CDS             complement(10635..11399)
                     /locus_tag="ctg43_9"
                     /transl_table=11
                     /translation="MLNQFSRTELLLGKEAMDKLENARVAVFGIGGVGGYVCEALVRSG
                     VGAFDLIDDDKVCLTNLNRQIIATRKTVGQYKTEVMRDRILDINPKADVRIHNCFYLPE
                     NAADFDFSEYDYVVDAVDTVTAKIELIMRAKEAGTPVISSMGAGNKLDASAFRVADIYK
                     TKVCPLAKVMRRELKKRGVKKLKVVYSEEQPIRPIEDMAISCRSHCICPPGAAHKCTER
                     RDIPGSVAFVPSVVGLIIAGEVIKDLTAEYRR"
     CDS             complement(11393..11581)
                     /locus_tag="ctg43_10"
                     /transl_table=11
                     /translation="MKRLVIKNKRKIWLWFLFIVLLILACRAAYVTGNKNMQIRDEAVE
                     EQQVENVMGQDKVERLC"
     CDS             complement(11593..13011)
                     /locus_tag="ctg43_11"
                     /transl_table=11
                     /translation="MRKTKIICTMGPSTDKGDVMEQLVREGMDVARFNFSHGPHDEQRG
                     RIQKLRELRKKYDRPVAALLDTKGPEIRLGCFKDGKVSLEEGQIFTFTNKDIEGTNECV
                     SITYKELYKDVQPGGHILVDDGLVDLEVQDISGKDIVCKVINAGVIGDKKGVNVPGANL
                     KMPFISKKDHDDLLFGIQEGFDFVAASFTRTANDIREVRKILKENGGEEIQIIAKIENQ
                     QGVDNIDEIIEAADGIMIARGDMGVEIPPEYVPVIQQKIIQKVYTAGKPVITATQMLDS
                     MISHPRPTRAEATDVANAIFQGTSATMLSGETAAGKYPVQALQMMSRIAEHMEQNIDYN
                     TIFKKTDRNENPDITNAIAHATCLTAIDLKASAILSVTKSGSTAHMMSKHRPGCLIGAC
                     TSSERVLRQLNLSWGVYPMLIKEEYSSEILCLRAIEAAQKHKLVKVGDTIVFAGGVPLG
                     IPGRTNLIRVCTVE"
     CDS             complement(13265..13795)
                     /locus_tag="ctg43_12"
                     /transl_table=11
                     /translation="MNYNRLENSLIDVIKEEQAKLGYMKEKISLYYPLSSLNHFFGNET
                     DAAGMMEILKDFPSYIEEKFGEVAVSHRGDRFCFTVSEKASEYVHNNMKENEFIKALIE
                     LVGRHGCTIEEIKELFHSYSDKIITEPMDNEEFDVMIRFDDGSDPYYYCFKDEGCHIIY
                     HRFLPEDYADFGF"
     CDS             complement(14127..15653)
                     /locus_tag="ctg43_13"
                     /transl_table=11
                     /translation="MAKETRIMGKRAAGILMPISSLPSDYGIGCFSKSAYEFVDWLKEA
                     GQTYWQILPLGPTSYGDSPYQSFSTFAGNPYFIDLDTLVEEGVLDKKDCEKVNWGKKPD
                     EVDYEKIYKGRYPLLRKAYENSDISKNPDYQKFVAENSWWLSDYALFMAVKDRFEGVEW
                     TKWAEDIRLRWNNAMDYYREELYFDIEFQQYMQFKFYEQWMKLKSYANSKGIQIIGDIP
                     IYVAMDSADAWAHPELFQLDQDNVPLAVAGCPPDGFSATGQLWGNPLYRWDYHRNTGYQ
                     WWISRMSYCFRLYDVVRIDHFRGFDEYFSIPYGDKDARGGHWEKGPGIDLFRKIEQALG
                     WKQVIAEDLGYMTDSVRHLVYESGFPGMKVLEFAFDSRDSGCASDYLPHNYPENCVAYT
                     GTHDNETIVGWWNSITAAERKLARDYLCDHATPEEELYKCFISLIMRSAARVCVIPMQD
                     YMGLDNRFRMNKPSTVGTNWKWRIKKRDLTKKLQKEIYDVTLRYGRKNWD"
ORIGIN
        1 gcagatacgc ctataatttt tgaaaattca tgtatagaat aatatttact caaagaatca
       61 actcctttca ataatattct actctaatat cttgcaaaac tcaacatgtg cttatatgat
      121 tttataattt atatttaact gttaataacc ttccaaacat ctgtattatt tattttttat
      181 atcagcaata tagaaatctg tcaattacat tactgttcac tccgttctca gtaacgtagc
      241 caaaattcat tcaggaacat aaattttaca gcaattatcc aaaacccggt tgacaatttc
      301 ctctctataa atgtataatg taacccaaga aaacatttgt ccaccctatt cggacaatga
      361 atatccctat atcagccaaa tgccatgaca gggaggagta cacaaccccg ggaagcacag
      421 agagaaagca gtcggtgcga gctttcgtga acgaattgtg gaagtagccc ccgagcagtg
      481 aaccaaaccg catatccagt ctgatgatcc atagatccag acagacatgc caagtaggct
      541 tcaacgtcag ttccacgtta caggaacaca gtatatcagt actgacaaag tgcagagcca
      601 gactctgaat acaggtggta ccgcggaaac attttcgccc tgggcaaaca agcccagggc
      661 gttttttact atattcagaa ttgtgggagc tgctttacag cgttctcagc agaatcagcg
      721 cagcgccatt ctgcccctgt atcagccaat acacagctca gaaatttatt tgtttggtgt
      781 gcatttgcag gagtcgtgta gatcttagtg cctggaaatc tgcgttgttc agaaaaatct
      841 cactgtctga gcgcagcgag tttgagattt ttctgaacgc ttttagcaga ttttcagaca
      901 cttagatcta ctaggctccg aaaccgcaca ccaaacaaat aaatttctga gcgtcctata
      961 cacatacaca aaggaggttt accaaaatat gaaacaaata tccggcaaca aactcttagt
     1021 caaagcctta aaagaagaag gcgtagaata cctcttcggc taccccggag cctgtaccat
     1081 cgacatcagt gatgaactct acaaacagga cgatgtcaaa atcatcctcc cccgtcacga
     1141 acaggccctt gtccacgaag ccgacgccta cgccagaacc accggcaaag tcggcgtatg
     1201 tctggtaacc agcggtcccg gagcaaccaa ccttgtaaca ggacttgcaa ccgccaacta
     1261 tgacagcgta cctcttgtat gcttcaccgg ccaggtagcc cgccacctca tcggcaacga
     1321 tgcatttcag gaagtagaca tcgtaggaat caccagaagc atcaccaaat acggcgttac
     1381 tgtccgcaga cgtgaagacc tgggacgtat catcaaagaa gccttctaca ttgcccgcac
     1441 cggccgtccg ggacctgtcc ttatcgacct tccaaaggac gtaatggcag aactcggcag
     1501 cgctgaatat cctaaaaatg taaacatccg cggatacaaa ccaaacacag atgtccacat
     1561 cggccagctc aaacgtgcca tcaaactttt aaataaagca aaacgtccct tattcctggc
     1621 aggcggcggt gtagtaatct cccgcgccca tgaaattttc cgagaagtag tggaaaagac
     1681 aaaagtaccg gttgtcacaa ccgtaatggg aaaaggctct atccccacag accatccgct
     1741 ctatatcgga aaccttggca tgcatggtgc ctatgcagca aatatggcag tcagcaactg
     1801 cgatgtgctg ttctccatcg gaaccagatt caatgacaga atcaccggaa aacttcatga
     1861 atttgcacca catgcccaga ttatccacat tgatattgat acagcatcca tttcccgaaa
     1921 cattcaggtg gatatcccca ttgttgctga tgcaaaagag gctatcacca aaatgaacga
     1981 atacgtccag gaatgttcaa cggacaagtg gcttaacctg atcaaaaact ggaaagaaga
     2041 gcatccgctt aaaatgcgtc caaatgatct tttaagtccg atggatatcc tgaaagagat
     2101 caacgaacag tttgagaaca gtattatcgt aacagatgta ggacagcatc agatgcttgt
     2161 ctcccagtat gcggaaatca cagagggcaa acagatgatc atgtccggtg gtctgggaac
     2221 catgggctat ggtcttccag gcggcatcgg agccaaaatc ggaaatcccg acagacctgt
     2281 catcgttatc tccggtgacg gcggtgtgca gatgaacatt caggagcttg caactgcagt
     2341 tctggaagaa cttcctgtta tcctgtgcat ctttaacaat gaataccttg gaatggtacg
     2401 ccagtggcag aaactcttct acggtaaacg ctacgccatg accaacctgc gcgccggagc
     2461 actttcccgc cgcacagaag gcatggaata tccacagtac acaccggatt tcattaaact
     2521 tgcagaaagc tacagggcaa aaggaatccg tgtcacaaag aaagaggaaa ttgcagcagc
     2581 cttcgaggaa gcaaaaaaga acacaaaggc acctacagta attgaattca tcattgaccc
     2641 tgaggaaatg gtttatccta tgatcaaacc aggcggaact ctagaagata tgattatgga
     2701 ctgttgatca ggaggaaaat tattatggat aaaggaatga aaaaaagatg gatttctctc
     2761 tatgttgaga accaggtagg tgttctgtcc aaaatctccg gacttttctc cggaaaaagc
     2821 tacaatctgg acagtcttac tgtaggaacc accgaggacc ccacagtatc tcgaatgacg
     2881 atcgcaactg tcagtgatga tgaaactttt gagcagatca aaaaacagtt gaaccgtatg
     2941 atcgaggtta ttaaggttat tgatttcaca gacgtatttg tccgcatgaa agagattctg
     3001 tatattaagg tttttaactg ttccaaagaa gataaggttg aactgtttca gattgccgaa
     3061 accttcaagg caaaggtcat tgactatggc aaagacagcc tgctcctgga atttgtccag
     3121 acagcaacca agaatgacgc agtagtgaaa ctgatcaagg aagaatttca cagaattgaa
     3181 gtggtacgtg gaggaagtgt aggaatcgaa tctatcagta tgatggaacg ataaaacttt
     3241 ttctgaaatt tttataaagg gaggattgtc gcattgttct taatgctcag tcctcccttt
     3301 acttacggtt cttccgtctt ttcgtttttc atctgtgctt tcgcttttcg cccaatccgt
     3361 gcattgctgt tcataatact ggcacgggtg atcttatcat ttccaaattt catccggatc
     3421 tcatccatag ctgcatccag ctttctgtgg cgttctttat tttctgtatc ttcaaacaga
     3481 gacatctgtt cataagtgcc atctgtaagg cctgtcagtg ccacaccaat cagacgtagc
     3541 ggctgtcctt tccagaattc tttaaaaagt cttgtagcat ttatataaat ttcatctgta
     3601 agatctgtag cattttccag ctttgtctgg tgtgaacggt ttctgaaatc caaagtacgg
     3661 aaagtcacgg aaatacagtt gcatttctta tcttttctgc gcattctggt tgccagaaca
     3721 tcacactgct ccaaaagtat gggaaacacc tgctctatgg aagtaatatc atcgttaaaa
     3781 gtagtttcca cgctgaaacc ttttgcctca tcaggcactg cttttacagg ggaatcatcg
     3841 atacctctgg catattgcca tagctgatgt cccgtttttt ccccaagcca gtactgcaca
     3901 ttggatgctc tttctcttgc cagatcaccg atggtacgga ttccctgatt cagaagcttc
     3961 tgctcggaag cttttcccag aaacagcaga ttacggatag gaagaggcca cattttctcc
     4021 gggatttcat ccgggaacag agtgtgtact ctgtccggct tttgaaaatc tgatgccatc
     4081 tttgccaaaa gcttattggt agaaattcct acatttactg tgaatcccag ctctctgtga
     4141 atcttgtctt tcagctcatg agcagcagct acagggtcag gatagatcag agaagtacct
     4201 gtcatatcca gaaatacctc atcaatggaa aaagattcca tcacaggtgc aaaggaagca
     4261 cagattgctt taaatgcccg ggaacattta tcgtataatt caaaatcact gggaacgatc
     4321 accaaattgg ggcatttccg aagagccata gctactggct cgccggtctg gatcccgtat
     4381 ttttttgcag ggatagattt ggcaaccacg atacctgtcc gtttctttgg atttcctcct
     4441 acacaggaag gaatttctct gagatccggc aacccctggc tcacccttct ggctgattcc
     4501 caggaaagaa atgcactgtt tacatcaata tgaaaaatta accgttccgt acttttcact
     4561 gttcttcctc caatatatga attgcgctct tcatatctga tgatttcatt ttaccctgat
     4621 ctgctctcca gggtaagaac ctcgtttgtc caaaaaagtg tctttatttg catcatcttg
     4681 tctgagctgt tactgtattt atatttgttt gatttcactc tgctatcaga gttttgaaca
     4741 acaacgccgc acttgccata cggcagtgcg gcgtctgtat ttcgctaccg gtcacattgt
     4801 tcccggtaac tttttttact taattctgag gattcatttc ctctcgatat atacttatcg
     4861 attagtcata aaggttagga gcaatttctt cgctgtccat atttgtggaa tcataccagt
     4921 atccagttca gcctccagcc attcataaga gaattccggg aatgtctgat gtttgaaatt
     4981 tttccatgtt actcctttct catgaagtaa ctgtctacac ataagcaaac agtgctatcg
     5041 ctgtcattga tcagcaataa gcccccgtgt tttcatatag ttccattata ccttctcatt
     5101 ttcccgaagt caacataatt taacatgtat cagccgttta tttgtgttgt tttttattta
     5161 atttttgttg tatttcagtt gtttttattt tgttttctca ttgacattta aatcctcatc
     5221 tgtcatactt gaatataatg aatgcaccat caaacagcag ctttgcatct cccgtaaggc
     5281 tcttatcata tatagaaacc gctctggaaa ggagacaaac aatgtatctt tctgacatcc
     5341 acacacattc tatcgccagc ggtcacggaa ccacctgtac catctctgac atggcaaaag
     5401 cagccagcaa aaaaggactg aaactccttg ggatttctga acacggcccg ggaactctgg
     5461 cttccggaac ttcttcttat ttcagaagcc ttccttttta tcccagaaaa agattcggca
     5521 tagatattct ttacggagtt gaactaaaca tcctggacag tgcaggacat acagatctgt
     5581 cagatgaact gctgaacaac ctggattacg ctatcatcag tatgcatcgg cagaactacc
     5641 gttcaggctc tgtatctcag aatacagaag cttacatcaa tgcaatgaaa catcctgctg
     5701 taaaaatact cggccactgc gacgatacac atttccctgt agattatgaa acgctggcaa
     5761 gagcagcttt acgggaaaat gttatttttg aaataaacga agcttccctc gcacccggag
     5821 gatatcgggg agacacaaga gccaatgcag ccagaatcct gtatctctgt cagagatatc
     5881 agcttcctgt tattttgtcc agcgacagcc acggaaaaga acatgttgga gatttcacct
     5941 atgccgaaga attcgttcac cagctcatgt ttccggaaac tcttatcctt aacaaccagc
     6001 ttcccaaatt aaaagttttc cttcagacac gttaaaagaa tgttcctcaa agggacattc
     6061 ttttatttta tgcattgttt tttgcattgt gttattttgt ttattttcta taatttcttg
     6121 tcaaaaaaga cgacatttta gtacatttta attaacaaaa ctcacttaac catttacata
     6181 tctcgtgata gatcagtctt actgtaggaa ccaccgagga tcctacagta tcccgaatga
     6241 ctatcgcaac agtcagcgat gatgaaacct ttgaacagag caaaaaacag ttaaaccgca
     6301 tgattgaggt tatcaaggta atcgacttca cagatgtatt tgtcagaatg aaagaaattc
     6361 tctacatcaa ggttttcaac tgctccaggg aagataaagc agaactgttt cagattgcag
     6421 aaaccttcaa ggcaaaagtc attgactacg gcaaagacag cctacttctg aaatttgtcc
     6481 agacagccac caagaatgat gcagttgtca aactgatcaa ggaataattc cacagaattg
     6541 aagtagtacg tggtggaaac gtaggaattg aatccatcag catgatggaa cgctaaatct
     6601 cataatcaat atttttttac aggatataga aacacctcta tatcctgtat ttattttcaa
     6661 acatactata aaatattgca gtttttaatc aaatgtgtta ttgtttacgg gagcgttatt
     6721 cgaaagaaaa tgcatctgat ttccacatct gacagtctgg tggataaagt catccacttc
     6781 acagtctggt taaatttgtg aggcgacctg taaggcgtct acacaccgga aacttttacc
     6841 ggaagatatt tcttgtttca tatcttttgt tctgatgtat atttttcata acgcctgatc
     6901 cccatactct aaactgtctg aaaagcaggg gacgcattgc gccgttttat cagaccaaaa
     6961 ggagaattca tatgaacaca acaacaacta ctacaacagc tgccacaaaa agaagcagca
     7021 ctctttacat ggtagagctg gctatgatga ttgccattat tctgctcatg tcctttaccc
     7081 cgctgggcta ccttcgtact cccggcttat ccatcactct tctcaccatc ccggtagctg
     7141 taggagctat catcctcgga ccgaaaggtg gtgctgtatg cggacttgct ttcggtgcaa
     7201 ccagcttcta tatggctgtc acaggaagtt cagctttcgc tgccgcactt tttaacatta
     7261 atccatttgg cacttttatt gtgtgtatcg tggcacgtgt gctggaagga tggatcacag
     7321 gacttatttt cgcagcatta tataaatcac cggcgaagaa attttcctat tacgttgctt
     7381 cactggcatg cccgttactg aatactttct tcttcatggg ctttttatgt ctcttcttct
     7441 acaacacaga ttacattcag ggtattgttt ccagtcttgg agtaagcaat cctgttgtct
     7501 tcgttgctgc ttttgtgggc gttcagggac tgatcgaagc gggcttctgc tttgtagtgg
     7561 gaagcatcgt ttccaaggca ctttctgtgg cactgaaacg tgcataatct ttaaaagaac
     7621 agccgtttac caaacaaccc tgactacatt gtcactgtag tcaggatttt tttatccggc
     7681 acatttaaag caggaaccct acctgattcg gttaatacaa aggagatttt tatgtcatta
     7741 ttaaaagaga tttctattac agatctttca aatttacgca tcggtcatgc ttccgattat
     7801 aatgcccaga ccggggtaac cgttctttac ttcccactgg gtgcaaaggt tggctgtgat
     7861 atcagcggag gcggccctgc ttccagagaa actcctctca cctctcctgt cactgccgac
     7921 aatcccatca atgctattgt cttgtccgga ggttctgctt atggactggc tgctgctgac
     7981 ggtgtgatga actatctgga atcacaaaat atcggttata acaccggtgc agccctggtt
     8041 cctcttgtat gccagtcctg tatctatgac ctctcttacg gagatcctaa aatacgtcca
     8101 actgcaaaaa tgggcgaaga agcctgccgt caggcatttg caggaacaga tgccagaacc
     8161 gggaatatcg gcgcaggtac cggtgcaact gtgggaaaac tttacggtat gaaacaatcc
     8221 atgaagtcag gtcttggtat tgccgctgta tcagtgggaa atttccagat ggccgcaatt
     8281 gtcgttgtca atgcactggg agatatcttt agtccacaaa atggtcagaa aatcgcaggg
     8341 ctgaaaacgc ctgacagaag cgggtttctg gatagtgtcc acgaattata ccgctttatg
     8401 acacctcatg accagtttac cggcaatacc accatcgggg ctgtgatcac caatggggca
     8461 ttttcaaagg ctgaactgaa taaaattgcc tctatgaccc gctgtgccta tgccagatgc
     8521 atcaatcctg tagcaactat ggctgacggc gattccatct atgctgccag cattggcgat
     8581 gtttctgtag atatcaatat ggcaggaact ctcgccgcag aagtcatggc tcaggctatc
     8641 caaaatgcca tccatacttc ccggatccag gatgaagaat ttttgaaata tgtataacag
     8701 tccgctataa aagcgcagag aaaaagtatc atctctgcgc ttttattctt cctgtctgtc
     8761 ttcatttttc atctgtgctc tggtttttct ccaagccaga gctgtacatt tgcttcccgt
     8821 tcccttgcca gatcaccaat agtacggatt ccctgattca gaagcttctg ctcggaggct
     8881 tttcccagaa ataacaggtt acggacagga agtggccaca ttttctccgg tatttcgtcc
     8941 gggaacagcg tgtgtactct gtccgtttct ttggatctcc tcccacacag gagggaatct
     9001 ccctgagatc cggcagcccc tggcttaccc ttctggctga ctcccaggaa agaaatgcgc
     9061 tgtttacatc aatatgaaaa attaatcgtt ccatactttt taatatatct caatcatatt
     9121 tttgcagact tccaatcatc ttaatcccca ttatcatcaa cacagggaaa atcagtgccg
     9181 caaagattcc aagtttcaga ttatcattca gtgctcctga aatcatcccc acataggttg
     9241 gtccggatga gcatcccaca tctccagcaa gggcaaggag ggcaaacagg gctgttccgc
     9301 cacgctttac tgaggcagcc gccatgctga aggttcccgg ccacataata cctacagaca
     9361 gaccgcaaac cgcacatcca aggattccca acgcaggtac cgggataaat gcgatcatca
     9421 gataggaaac catgcacaga actgcactgt attgcataaa gcgttccaga ttgattttat
     9481 ctccaaattt tccataaaat gcccttgaac ttcccataag aattgcaaac gccatgggac
     9541 ctgccagatc tccgatagtt ttattgattc caaagctttt ctcagccaga gtagaagccc
     9601 actggcttac cgcctgctca ctggctcctg cacagagcat cattaacatc agaacccaga
     9661 agattttttt cttaaaaagc tctcccatag tcagcccctt ttcaccctca tccagcagtg
     9721 gagcaatggg aactctggta aaaaagattc catttgcaat gggaatcaat gcccacacca
     9781 gcgccatata tttccagttt gcaatcccga aaatacgaaa gaataatgta gaaagaagta
     9841 ccactcccac atgtccccaa cagtaaaagg aatgaaggag actcattgct ttttccttat
     9901 tatctgtagg gcaggcttcc accacaggac ttaccagcac ctccagcaat ccgcctccaa
     9961 tggcatagat cataactgca atgagaagtc ccacaaacgg atttcccagg cactccggca
    10021 atactgtgag caaaatcaga cctgcagccg ccattgcatg tgccaggatc atagatgcac
    10081 gataacctat tctgtccaca aatccaatcg atgccagatc taccagcaac tggatcccga
    10141 aattaaaagt aaccagaagt gtgatcttct gcagcgaaat cccgtaactg ccctgaaatg
    10201 tcagaaacag cagaggaacg aaattgttca caatggcctg cactacatat ccgataaaac
    10261 aggcctgcac tgttctgttg taatttgttt tcattcgata tgatatcctc caatctgaaa
    10321 tttattagtt actgagaacg gagtaagcag taacaattta ttacgctgat atcgttcagg
    10381 cattctcctt caccaaattc tgcaccttca cagttctatc aatcaataat gacagtgtat
    10441 cacagattct ttcttttttc tttcattata ttttgaaaat cctataaatt tttatgttat
    10501 tttgactttt tctcatataa caattctata cactctaaca ggtaatccat caatccaatt
    10561 caaaatattt cccgcaaaaa aagatgtgta ccataccatt tctgacacca tacacatctc
    10621 aaaataaaca cttcttatct tctgtactcc gcagtcaggt ctttaataac ctctcctgca
    10681 ataatcagcc cgacgacaga cggcacaaag gccacactcc ccggaatatc tctgcgctcc
    10741 gtacacttat gcgcagcacc cggaggacaa atacaatgcg acctgcagct gatcgccata
    10801 tcttcaattg gtctgatcgg ctgttcctct gaataaacaa ccttcagttt cttcacacca
    10861 cgcttcttca gctctctacg cataaccttc gccagcggac acaccttcgt cttatagata
    10921 tccgccaccc gaaacgcact ggcatccagc ttatttccgg cacccatact gctgataaca
    10981 ggagtccctg cctcttttgc acgcatgatc agttcaatct tcgcagtcac tgtgtccaca
    11041 gcatctacca cataatcata ctcactaaaa tcgaagtcag cagcattctc cggaagataa
    11101 aaacagttat ggattctcac atctgctttc ggattaatgt ccaggatcct gtcccgcatc
    11161 acctctgttt tatattgacc aacagttttc ctggtggcaa taatctgtct gttaagattc
    11221 gtcaggcata ctttgtcatc atcgatcaga tcaaaggccc ctacgccgct tctgaccaat
    11281 gcttcacata cataacctcc aactcctccg attccaaata ctgccacacg ggcattctcc
    11341 agtttatcca tcgcttcttt tccaagaaga agctcagttc tcgaaaattg attcagcata
    11401 atctctccac tttatcctgt cccattacat tctctacctg ctgttcctct actgcctcgt
    11461 ctcttatctg catattctta tttcccgtga catatgcagc cctgcatgcc aggatcagaa
    11521 gcacgataaa cagaaaccag agccagattt ttcttttatt ttttatgact aaccgtttca
    11581 taacctgctc cactattcta ctgtgcagac gcggatcagg tttgttcttc ccggaattcc
    11641 aagcggtaca ccaccggcaa atacaatagt gtcaccaact tttacaagtt tatgcttctg
    11701 tgctgcctcg attgctctca ggcaaaggat ctcagaactg tattcttctt tgatcagcat
    11761 cgggtaaaca ccccaggaca gattcagctg gcgaaggact ctctcagaac ttgtgcatgc
    11821 accgatcaga catcctggtc tgtgtttgga catcatatga gctgtacttc cggattttgt
    11881 cactgaaagg attgcactgg ccttcaggtc gattgctgtc aggcaggttg catgtgcgat
    11941 tgcatttgta atatccggat tctcatttct gtctgttttc ttaaagattg tattgtaatc
    12001 aatattctgt tccatatgtt ctgcaatgcg gctcatcatc tgaagtgcct gtaccggata
    12061 tttacctgct gctgtttctc cggaaagcat ggtagcactt gttccctgga aaatcgcatt
    12121 ggcaacgtct gtagcctctg cacgtgttgg tctcggatga gagatcatgg agtcaagcat
    12181 ctgtgttgct gtaataaccg gttttcctgc tgtgtaaact ttctggatga tcttctgctg
    12241 gataacaggt acatattccg gcggaatctc aacacccatg tcacctctgg cgatcatgat
    12301 gccatctgct gcttcaataa tctcgtcgat attgtcaacg ccctgctggt tctcaatctt
    12361 tgcaatgatc tggatctctt caccgccgtt ttctttcagg atttttctta cttcgcggat
    12421 atcgtttgca gtacgtgtaa aggatgctgc aacgaaatca aatccttcct ggataccgaa
    12481 gagaagatca tcatgatctt tcttactgat aaatggcatc ttcaggtttg cacccggaac
    12541 attgacaccc ttcttgtcgc caatcacacc tgcattaata accttgcaga caatgtcctt
    12601 tcctgagatg tcctgaacct ccaggtctac aagtccatca tcaaccagaa tatgtccgcc
    12661 cggctgcaca tccttataaa gctctttata agtaatgctt acgcactcat tagttccttc
    12721 aatatcttta tttgtaaatg taaaaatctg tccttcttcc agagaaacct tgccatcctt
    12781 gaagcatcca agtctgatct ccggtccctt tgtatcaaga agtgctgcaa caggtctgtc
    12841 atatttcttg cgaagttctc tcagtttctg gatacggcct ctctgctcat cgtgaggtcc
    12901 atgtgagaag ttgaaacgtg ctacgtccat tccctctctc acaagctgct ccataacatc
    12961 gcccttatca gtagacggtc ccattgtaca gataattttg gtttttctca tttaatcttt
    13021 ccctccaaac tgtcaactca attttatcta ttttattcct gtaaaataat gtaataaaat
    13081 tttacctgtt tctataaatg aaaacattaa atcaaataaa aattaccatt attgagacta
    13141 tctgtcaata tagaatttcg acttattttt gttgatattt gacaaaaaaa taacatactt
    13201 ttgttgcaaa tatcacatat atttttgctg atccgacagt tggaaaattt ttcactcatt
    13261 cttatcagaa tccaaaatct gcatagtctt ccggcagaaa tctgtggtaa atgatatggc
    13321 atccttcatc tttaaaacaa taataataag gatctgatcc atcatcaaag cggatcatca
    13381 catcaaactc ctcgttatcc attggctcag taatgatttt atctgaataa gaatggaaca
    13441 gttctttaat ttcctctatc gtacatccat gtctgccaac cagttcgatc aatgccttga
    13501 taaattcatt ctctttcata ttattatgta catattcgga agctttttcc gaaacagtga
    13561 agcagaaacg atctcctctg tgtgatactg ctacttcacc aaatttctct tctatataag
    13621 aaggaaaatc ttttaaaatc tccatcatgc ctgcagcatc cgtctcattg ccaaagaaat
    13681 gattcaggga actgagcgga taataaaggc tgatcttctc cttcatatat ccaagcttcg
    13741 cctgttcctc tttgatcaca tcaatcagac tgttttctaa tctgttatag ttcatttatt
    13801 ttccctcctg aaaatctgtc cttttgcttt ttctggttaa tattttatca gacattgccc
    13861 gaaaatcaat gcatttcttt ttcaattgta cgcctgccaa aacaatttta atgttttctt
    13921 tttcatacaa aaataaagag cttgcgaaac tgtccttttt ttctccctct gacaaataac
    13981 tctgactgga taaaacaaaa cagataaaac caaccacttc gttgcttttt taaccaaata
    14041 accgcttgat tcggttaaaa aaacagcgtt ccgaatatta tttatatccg aaacgctgtc
    14101 attattccaa ttatttcatt atgtatttaa tcccagttct tacgtccgta acgaagtgtc
    14161 acatcatata tttccttctg gagtttcttt gtaagatctc tcttcttgat tctccacttc
    14221 cagttcgtac caactgtaga tggtttattc attcggaatc tgttgtccag tcccatatag
    14281 tcctgcattg ggataacgca gacgcgcgca gcactgcgca tgatcagact gatgaaacat
    14341 ttatacagtt cttcttccgg tgttgcatga tcacacagat aatctctcgc cagttttctc
    14401 tcagctgctg tgatgctatt ccaccatccc acgatagttt cattatcatg ggttcctgta
    14461 tatgccacgc agttctccgg ataattatgt ggcagataat cactggcaca tccggaatct
    14521 ctggagtcaa acgcaaattc cagaaccttc attcccggga agccgctctc atataccaga
    14581 tgacgtacgg aatctgtcat atatcccagg tcctctgcga taacctgctt ccatccaagc
    14641 gcctgttcaa tcttacggaa cagatcaatt ccgggaccct tttcccagtg tccgcctctt
    14701 gcatctttat ctccgtatgg aatagagaaa tattcatcaa atccacggaa atgatcgatt
    14761 cgcacaacat catacagtct gaagcagtaa ctcattctgg aaatccacca ctgatatcct
    14821 gtatttctgt gataatccca gcgatataac ggatttcccc ataactgacc ggttgcagaa
    14881 aatccatccg gagggcatcc tgctactgcc agtggtacat tatcctgatc cagctggaac
    14941 agctccggat gcgcccatgc atcagcactg tccattgcaa cataaatcgg aatatctcca
    15001 atgatctgga ttccttttga atttgcatag gatttcagtt tcatccactg ctcatagaac
    15061 ttaaactgca tatactgctg gaattcaata tcaaaataga gttcttcacg ataataatcc
    15121 atggcattgt tccagcggag tctgatatcc tcagcccatt tggtccattc tacaccttcg
    15181 aaacggtctt ttactgccat aaacagagca taatctgaca gccaccagct gttctctgct
    15241 acgaatttct gatagtcagg attcttgctg atatcactgt tctcgtatgc ttttctcaga
    15301 agcggatatc ggcccttgta gattttttca taatctacct cgtcaggctt ctttccccag
    15361 ttaactttct cgcagtcttt cttatcaaga actccttctt ccacaagtgt atccagatca
    15421 ataaaatatg gattacctgc aaatgtagag aaagactgat atggagaatc tccatagctg
    15481 gtcggtccca atggcagaat ctgccagtaa gtctgtccgg cttcctttaa ccagtctaca
    15541 aattcatatg cacttttgga aaaacatccg atgccatagt ctgatggaag actgctgatc
    15601 ggcattaata ttcctgctgc tctttttccc atgattcttg tctccttcgc catttttcac
    15661 ttttaccgcc tatactttat ctagtacata taagcagttt ttctatacct tatgcgcaat
    15721 tgtttttttt attatatcta ttttttgtgc aaattgcaat acaactttca tgttatccat
    15781 tttttcgtga aaattactaa tcattgctta gttcttttcg tcatcttcca tattaaacac
    15841 caatcatttc cactcagaga attgtcgtca agcggatatt cacaatctgc ttcgctacgc
    15901 agctctatac cgaataactg ctccgcattt catcagaagg agcttatttt ttatccatat
    15961 caaaaactta taattacaat gcaatatttc tattttacgt ttcatttctg atatgatagg
    16021 atgtgttcgg ttaaaaaata acaaagtaac actccaactt atctgttgag aaacgtttat
    16081 cattaactac caccagaaaa tttcttatac agatatcttc gacatcttaa gctatacaca
    16141 tcaaagacaa agaaagaggt aagaaaatgg aagacaacaa attatgtctg gaaaagcagc
    16201 ctttaaacca ggaaatgctt gacaaaatcg atgcttactg gcgtgcagct aactatctgt
    16261 ctgccggaca gctctatctt ctcgacaatc cgcttctgag agagccatta actatggatc
    16321 agatcaagaa aaaaattgtt ggtcactggg gaactgtacc gggacagaac ttcgtttatg
    16381 cacactgcaa ccgtgtcatc aaacgttatg accttgatat gatcctgctt tccggtcctg
    16441 gacatggcgg aaacttcatg attgccaata cctatctgga aggttcttac agcgaagttt
    16501 atcctaacat cagccaggat gaggaag
//
