LOCUS       c00141_gnlPro..        15659 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|EJOCIBNC_208.
ACCESSION   c00141_gnlPro..
VERSION     c00141_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-06 03:59:24
            Original ID  :: gnl|Prokka|EJOCIBNC_208
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 15659
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..15659
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[185:5659]"
                     /cutoff="10000"
                     /detection_rule="(TPP_enzyme_C and not (PFL-like or
                     PFL_6_pcresol or PFL_9_tma or Gly_radical or Gly_430_pcre
                     or Gly_8-9_TMA or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and
                     minimum(2, [ALS_ss_C, AlaDh_PNT_C, Arginase, BKACE,
                     BcrAD_BadFG, Beta_elim_lyase, CPSase_L_D2, Cys_Met_Meta_PP,
                     ELFV_dehydrog, GRDB, Glu_syn_central, Glu_synthase,
                     Gly_reductase, HAAA1, HG2B1, HG2B2, HGD-D, HleuD1, HleuD2,
                     HleuS1, HleuS2, Homoserine_dh, ILVD_EDD, IlvC,
                     Lactoyl-CoA1, Lactoyl-CoA2, Lyase_aromatic, MAAL_C,
                     OKR_DC_1_5_lysine, OKR_DC_1_5_ornithine,
                     OKR_DC_1_7_arginine, OKR_DC_1_C, OTCace, PALP,
                     Proline_reductase, Sacchrp_dh_C, TPL, Thr_dehydrat_C, TnaA,
                     Urocanase]) and not (POR or POR_N or PFOR_II))"
                     /neighbourhood="10000"
                     /product="TPP_AA_metabolism"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      186..5659
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(TPP_enzyme_C and not (PFL-like or
                     PFL_6_pcresol or PFL_9_tma or Gly_radical or Gly_430_pcre
                     or Gly_8-9_TMA or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and
                     minimum(2, [ALS_ss_C, AlaDh_PNT_C, Arginase, BKACE,
                     BcrAD_BadFG, Beta_elim_lyase, CPSase_L_D2, Cys_Met_Meta_PP,
                     ELFV_dehydrog, GRDB, Glu_syn_central, Glu_synthase,
                     Gly_reductase, HAAA1, HG2B1, HG2B2, HGD-D, HleuD1, HleuD2,
                     HleuS1, HleuS2, Homoserine_dh, ILVD_EDD, IlvC,
                     Lactoyl-CoA1, Lactoyl-CoA2, Lyase_aromatic, MAAL_C,
                     OKR_DC_1_5_lysine, OKR_DC_1_5_ornithine,
                     OKR_DC_1_7_arginine, OKR_DC_1_C, OTCace, PALP,
                     Proline_reductase, Sacchrp_dh_C, TPL, Thr_dehydrat_C, TnaA,
                     Urocanase]) and not (POR or POR_N or PFOR_II))"
                     /neighbourhood="10000"
                     /product="TPP_AA_metabolism"
                     /protocluster_number="1"
     cand_cluster    1..15659
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(TPP_enzyme_C and not (PFL-like or
                     PFL_6_pcresol or PFL_9_tma or Gly_radical or Gly_430_pcre
                     or Gly_8-9_TMA or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and
                     minimum(2, [ALS_ss_C, AlaDh_PNT_C, Arginase, BKACE,
                     BcrAD_BadFG, Beta_elim_lyase, CPSase_L_D2, Cys_Met_Meta_PP,
                     ELFV_dehydrog, GRDB, Glu_syn_central, Glu_synthase,
                     Gly_reductase, HAAA1, HG2B1, HG2B2, HGD-D, HleuD1, HleuD2,
                     HleuS1, HleuS2, Homoserine_dh, ILVD_EDD, IlvC,
                     Lactoyl-CoA1, Lactoyl-CoA2, Lyase_aromatic, MAAL_C,
                     OKR_DC_1_5_lysine, OKR_DC_1_5_ornithine,
                     OKR_DC_1_7_arginine, OKR_DC_1_C, OTCace, PALP,
                     Proline_reductase, Sacchrp_dh_C, TPL, Thr_dehydrat_C, TnaA,
                     Urocanase]) and not (POR or POR_N or PFOR_II))"
                     /kind="single"
                     /product="TPP_AA_metabolism"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..15659
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="TPP_AA_metabolism"
                     /region_number="1"
                     /rules="(TPP_enzyme_C and not (PFL-like or PFL_6_pcresol or
                     PFL_9_tma or Gly_radical or Gly_430_pcre or Gly_8-9_TMA or
                     PFL_acetate1 or PFL_acetate2 or Gly_radical_scatole or
                     PFL_proline or PFL_toluene) and minimum(2, [ALS_ss_C,
                     AlaDh_PNT_C, Arginase, BKACE, BcrAD_BadFG, Beta_elim_lyase,
                     CPSase_L_D2, Cys_Met_Meta_PP, ELFV_dehydrog, GRDB,
                     Glu_syn_central, Glu_synthase, Gly_reductase, HAAA1, HG2B1,
                     HG2B2, HGD-D, HleuD1, HleuD2, HleuS1, HleuS2,
                     Homoserine_dh, ILVD_EDD, IlvC, Lactoyl-CoA1, Lactoyl-CoA2,
                     Lyase_aromatic, MAAL_C, OKR_DC_1_5_lysine,
                     OKR_DC_1_5_ornithine, OKR_DC_1_7_arginine, OKR_DC_1_C,
                     OTCace, PALP, Proline_reductase, Sacchrp_dh_C, TPL,
                     Thr_dehydrat_C, TnaA, Urocanase]) and not (POR or POR_N or
                     PFOR_II))"
                     /tool="gutsmash"
     CDS             complement(186..695)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: ALS_ss_C"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg141_1"
                     /sec_met_domain="ALS_ss_C (E-value: 2e-22, bitscore: 71.8,
                     seeds: 685, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDKGMKKRWISLYVENQVGVLSKISGLFSGKCYNLDSLTVGTTED
                     PTVSRMTIATVSDDETFEQIKKQLNRMIEVIKVIDFTDVFVRMKEILYIKVFNCSREDK
                     AELFQIAETFKAKVIDYGKDSLLLEFVQTATKNDAVVKLIKEEFHRIEVVRGGSVGIES
                     ISMMER"
     CDS             complement(713..2431)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: TPP_enzyme_C"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg141_2"
                     /sec_met_domain="TPP_enzyme_C (E-value: 4e-48, bitscore:
                     155.5, seeds: 323, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKQISGNKLLVKALKEEGVEYLFGYPGACTIDISDELYKQDDVKI
                     ILPRHEQALVHEADAYARTTGKVGVCLVTSGPGATNLVTGLATANYDSVPLVCFTGQVA
                     RHLIGNDAFQEVDIVGITRSITKYGVTVRRREDLGRIIKEAFYIARTGRPGPVLIDLPK
                     DVMAELGSAEYPKNVNIRGYKPNTDVHIGQLKRAIKLLNKAKRPLFLAGGGVVISRAHE
                     IFREVVEKTKVPVVTTVMGKGSIPTDHPLYIGNLGMHGAYAANMAVSNCDVLFSIGTRF
                     NDRITGKLHEFAPHAQIIHIDIDTASISRNIQVDIPIVADAKEAITKMNEYVQECSTDK
                     WLNLIKNWKEEHPLKMRPNDLLSPMDILKEINEQFENSIIVTDVGQHQMLVSQYAEITE
                     GKQMIMSGGLGTMGYGLPGGIGAKIGNPDRPVIVISGDGGVQMNIQELATAVLEELPVI
                     LCIFNNEYLGMVRQWQKLFYGKRYAMTNLRAGALSRRTEGMEYPQYTPDFIRLAESYRA
                     KGIRVTKKEEIAAAFEEAKKNTKAPTVIEFIIDPEEMVYPMIKPGGTLEDMIMDC"
     CDS             3370..3924
                     /locus_tag="ctg141_3"
                     /transl_table=11
                     /translation="MDYLSNNVAVNLKRIRKSKSMSLDQVSEQTGVSKSMLAQIERGTA
                     NPSLGVLGKITSGLRIEFQELIQPPRVDCCLVTPAELVPTKEVAGQYKVWTCLPYEDTR
                     LVEVYRIEVEPGGVYISGSHGEKTREYLAVMEGVLTVECHGEKYEIHRDQVFKFETDQE
                     HVYRNTGKEKACCTCFFLDYH"
     CDS             4442..5659
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: Beta_elim_lyase"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Aminotran_3"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg141_4"
                     /sec_met_domain="Beta_elim_lyase (E-value: 1.1e-07,
                     bitscore: 23.9, seeds: 43, tool: rule-based-clusters)"
                     /sec_met_domain="Aminotran_3 (E-value: 1.3e-109, bitscore:
                     358.9, seeds: 14, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKLKDTGLTFQDIKDKVNKYMIETYERFDFLAETAEGMYIYDENK
                     TPYLDFYAGIAVNSAGNCNPKVVAAAKDQLDDIMHTFNYPYTIPQALLAEKVCETIGMD
                     KIFYQNSGTEANEAMIKMARKYGIEKYGPNRYHIVTAKMGFHGRTFGAMSATGQPGNGC
                     QVGFGPMTYGFSYAPYNDLQAFKDACTENTIAIMVEPVQGEGGVHPATMEFMQGLRKFC
                     DENDMLLLIDEVQTGWCRTGAVMSYMNYGIKPDIVSMAKALGGGMPIGAICATAEVAKA
                     FTAGSHGTTFGGHPVSCAAALAEVNELLDRDLAGNAKKVGDYFAAKLEKLPHVKEVRHQ
                     GLLVGVEFDDTIGGVDVKHGCLDRHLLITAIGAHIIRMIPPLIVTEEECDKAVAIIEDT
                     IKSLEK"
     CDS             5892..6512
                     /locus_tag="ctg141_5"
                     /transl_table=11
                     /translation="MKHLVITIGCEYGAKGNAIGKKIAQDLGIKFYDRDLVDEIIKEVG
                     IPTDIMDRVEEGGTIAGKGAQGDVRGSFSKYADLTDRAIHVQKQIIRKLAQKEACVIIG
                     RSADYILKDTEGIQLVRAFIYAPNDVRVHNIMESHNLSEKDAKLLLDEKDKRYHKRHLA
                     LTGSNRGDRHNRDILINSDFLGIQGTAEYLEDLIAKKYGKKEA"
     CDS             6516..8036
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) AA_permease_2"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg141_6"
                     /sec_met_domain="AA_permease_2 (E-value: 6.5e-46, bitscore:
                     149.4, seeds: 50, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MEQKTSEFDKVLGAWDILVIAFGAMIGWGWVVSSGNWIESGGVLG
                     AAIAFAIGGIMIFFVGLTYAELTAAMPQCGGEHVFSYRAMGSTGSFICTWAIILGYVSV
                     ACFEACAFPTIITYLWPGFLKGYLYTVAGFDVYASWLIVAIVIAFLIMIININGAKTAA
                     VLQTVLTCIIGGAGIILIVASVVTGSVDNLQGQMFVGNGTGEAMKSIIKVAVITPFFFI
                     GFDVIPQAAEEINVPLKKIGKMMILSVVLAVVFYALVILAVGYILNPAEIIESQQGTGL
                     VTADAMAKAFGTKIMAKVIIVGGMCGIITSWNSFLLGGSRAMYSMAESYMIPPFFAKLH
                     PKHKTPVNSLYLIGALTMLAPFAGRTMMVWICDAGNFGCCLAYCMVSVSFLILRKKEPD
                     MARPYKVGHYKFVGFMAVVMSGLMLLVYCIPGSGGSLVFQEWLMVGSWSLLGVVFYAIC
                     KRKYKEDFGKLIELISDEDAASLMPEADDEELDVVIDAAIDRVLSSMA"
     CDS             8142..9326
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fe-ADH"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1035:Iron-containing alcohol dehydrogenase (Score:
                     374.1; E-value: 2e-114)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg141_7"
                     /sec_met_domain="Fe-ADH (E-value: 2.8e-114, bitscore:
                     374.1, seeds: 219, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNPFEFFIPQNITVGAGTLAKLPECAKKLGGSHAMLISGPTLRKM
                     GVVDKAADYLKDAGMAVDIFTDVEANPSVTTVEKATEAYKDSGADFIVALGGGSPMDVA
                     KAVGVTAKYGGSITEYEGAHKVPGKIVPLIAIPTTAGTGSEVTAFSVITDHSRDYKLTV
                     FSYELLPAYAILDPELLTSAPASVAAACGIDAFIHAEEAYVSTAASPFSDAMAEKAMEL
                     IGGNIRRFVARRTDLEAAEAMLTGSLFAGIAFSFARLGNVHAMSHPVSAFFNVAHGVAN
                     AVLLPVIAEYNALADHGRYLKIYNYISPIPAYEDEFEPLMLVDAIRELNEDIGIPEDLT
                     TAIRQAKKGEEISDEEIESKIDAMADDAMKSGNIAVNPRSSRKQDIVKLYYKAL"
     CDS             9596..10252
                     /locus_tag="ctg141_8"
                     /transl_table=11
                     /translation="MAKKKIYAVRKGHKTGLFATWAECQKAVSGYSGAEFRGFTEKEEA
                     LAFLNMETTGNVSGDKAKEAAGIVEVPENMVIAYVDGSFEKSIGRYAFGCVILTPDGQE
                     IRKSGSGSDSAGVAIRNVAGEMLGSMTAVNWAIENKYPAVEIRYDYEGVEKWVTGVWRA
                     KTPLTSKYAAHMQEAGKKVQISFCKIAAHTGNHYNEEADQLAKRALLKTDEEVRI"
     CDS             complement(10425..11216)
                     /locus_tag="ctg141_9"
                     /transl_table=11
                     /translation="MKKLLKKHFSFIIAVLMVISLIIIPRTAQAASVKLNKTKLTMNVG
                     GVYHLKVSGTNKKVTWSSTDSKVASVSSGKVKAKKTGTATITAKIGSKKLKCQIKIKDQ
                     RALYEKVLLQSGGKCFYLMDIDRNGTPDLIVSSNRGVIVDYSVYTIKNGKVIYADQCSG
                     KGMNYQILQYNTHYNGIHISWWTNGVGGSGSALWTLSGSKLVSTSRAYCSVAGFQTGKD
                     EQHMKNVSQASFNSYCDKHFRNCKQYTMWSNTSENRIKHLK"
     CDS             complement(11257..12795)
                     /locus_tag="ctg141_10"
                     /transl_table=11
                     /translation="MKNKNTGFKHLVLLFAFILCLFSCVSAKAANYYYEDGYKYTLSLG
                     KATIISYVGSDTDLTVPSILNGKPVVKIESSAFANNKNLCSVILPDTITSMGISVFAQC
                     ENLKSIHYPEGLDRIYYRTFAGCHNLTKVNISSNIKIIEDSAFAGCTSLTYLDLPKVKE
                     IGEYSFANCTSLSEVIFHKGFTYVGSASFKNCTNLKDVTLPLGTQTISYSAFEGCKALR
                     HIDFPSTLVFLKSASFKDTGLVHIIVPPSVTHEEQSVFLNCKNLEEAEYHGKVIEGFTF
                     ANCTNLKKLIIGPEVTYIGSSVFDGTTQLETLQIPATTNLHSRVFIGAEALHTIYGVKN
                     SPVEIAANNAGLNFVPVKDHSIKLNKKQLTLYTVKGKNSAVLKSVISGSTSTPTWNSSN
                     TKVVQVNATGKVTAKGAGTAYVTVTLGNKSASCKITVKKPVLNLKNKAITLKKGSSYTI
                     SCSAVPTGKITYKSSNTKCVTVNTKGKITARQKGTATVSIKCNGITQKLKVTVK"
     CDS             complement(12876..13646)
                     /locus_tag="ctg141_11"
                     /transl_table=11
                     /translation="MKKKKWFLVITSILLMLLTCTQIQAAAIKAPANIKVTASKKASVS
                     IKWSKVSNASGYEIWRANSAKGNYSKIKTIKTKNTTSYANKKLSAGHYYYKVRAYKTVN
                     GKTIYSNFSRYSGTTVKVLNLMKNLPPLSPSYVGKYSTIINKIGGMHKKSNSGYPSFYA
                     AGNKMIIGVNYNAKYSKNQKYVYICNRGNYGVGIGGMQLGMTLSKATAILNKNGLRSFN
                     NPTVFWWGNAASITLTIKNNIVTGFTYACAPTCD"
     CDS             13854..14324
                     /locus_tag="ctg141_12"
                     /transl_table=11
                     /translation="MSAKLVLTVKDSSRMAKDYSMSMMDKMFHPLKHNKILNSKAKIGI
                     LIDDEEEGTLYEASKTPYEINLQPGFHRITMIDPAKDNKKGNVNLIGSIIGVVEGNGIA
                     DTMATSRFAKSMAGAMFKTGDGYLDLNLKDGDIIKVQCQAGIGGKVSIKILK"
ORIGIN
        1 tccaccagac tgtcagatgt ggaaaacaga tgcattttct ttcgaataac gctcttgtaa
       61 acaataacac atttgattaa aactgcaatg ttttatagta tgtttgaaaa taaatacagg
      121 atatagcgtt gttcgttgag aagtatctac acactatatc ctgtaaaaaa tattgattat
      181 gagatttatc gttccatcat gctgatggat tcaattccta cacttccacc acgtactact
      241 tcgattctgt ggaattcttc cttgatcagt ttgacaactg catcattctt ggtggctgtc
      301 tggacaaatt ccaggagtag gctgtctttg ccatagtcaa tgacttttgc cttgaaggtt
      361 tctgcaattt gaaacagctc tgctttatct tccctggagc agttgaaaac cttgatgtag
      421 agaatttctt tcattctgac aaatacatct gtgaagtcga ttaccttgat aacctcgatc
      481 atgcggttta actgtttttt gatctgttca aaagtttcat catcactgac tgttgcgata
      541 gtcattcggg atactgtagg gtcttctgtt gttcctactg taagactgtc caggttataa
      601 cattttccgg agaaaagtcc ggagattttg gacagaacac ctacctggtt ctcaacatag
      661 agagaaatcc atcttttttt cattccttta tccataataa ttttcctcct gatcaacagt
      721 ccataatcat atcttccaga gttccgcctg gtttgatcat aggataaacc atttcctcag
      781 ggtcaatgat gaattcaatt actgtaggtg cctttgtgtt cttttttgct tcctcgaagg
      841 ctgctgcaat ttcctctttc tttgtgacac ggattccttt tgccctgtag ctctctgcaa
      901 gtctgatgaa atccggtgtg tactgtggat attccatgcc ttcagtgcgg cgggaaagtg
      961 ctcctgcgcg cagattggtc atagcatagc gtttgccgta gaaaagcttc tgccactggc
     1021 gtaccattcc aaggtattca ttgttaaaga tgcacaggat aacaggaagt tcttccagaa
     1081 ctgcagttgc aagctcctga atgttcatct gcacaccgcc gtcaccggag ataacgatga
     1141 caggtctgtc gggatttccg attttggctc cgatgccgcc tggaagacca tagcccattg
     1201 ttcccagacc accggacatg atcatctgtt tgccctctgt gatttccgca tactgggaga
     1261 caagcatctg atgctgtcct acatctgtta cgataatact gttctcaaac tgttcgttga
     1321 tctctttcag gatatccatc ggacttaaaa gatcatttgg acgcatttta agcggatgct
     1381 cttctttcca gtttttgatc aggttaagcc acttgtccgt tgaacattcc tggacgtatt
     1441 cgttcatttt ggtgatagcc tcttttgcat cagcaacaat ggggatatcc acctgaatgt
     1501 ttcgggaaat ggatgctgta tcaatatcaa tgtgaataat ctgggcatgt ggtgcaaatt
     1561 catgaagttt tccggtgatt ctgtcattga atctggttcc gatggagaac agcacatcgc
     1621 agttgctgac agccatgttt gctgcatagg caccatgcat gccgaggttt ccgatataaa
     1681 gcggatggtc agtaggaatg gaacctttgc ccattacggt tgtgacaacc ggtacttttg
     1741 ttttttctac tacttcccgg aagatttcgt gggcgcggga gattactaca ccgccgcctg
     1801 caaggaataa aggacgtttt gccttgttta aaagtttgat ggcacgtttg agttggccga
     1861 tatggacatc tgtgttgggc ttgtatccgc ggatgtttac atttttagga tactcagcgc
     1921 tgccaagttc tgccattacg tcctttggaa ggtcgataag gacaggtccc ggacggccgg
     1981 tacgggcaat gtagaaggct tctttgataa ttctgccaag gtcttcacgt ctgcggacag
     2041 taacgccgta tttggtgatg cttctggtga ttcctacgat gtctacttcc tgaaatgcat
     2101 cgttgccgat caggtggcgg gctacctggc cggtgaagca tacaagaggt acgctgtcat
     2161 agttggcggt tgcaagtcct gttacaaggt tggttgctcc gggaccgctg gttaccagac
     2221 atacgccgac tttgccggtg gttctggcgt aggcgtcggc ttcgtggaca agggcctgtt
     2281 cgtgacgggg gaggatgatt ttgacatcgt cctgtttata gagttcgtca ctgatgtcga
     2341 tggtacaggc tccggggtag ccgaagaggt attctacgcc ttcttctttt aaggctttga
     2401 ctaagagttt gttgccggat atttgtttca tatttgggta aacctccttt gtgtatgtgt
     2461 ataggacgct cggaaattta tttgttttcg ggtgcggttt cggggtctag gaactctaag
     2521 tgtctgaaaa tctgctaaaa ccgttcagaa aaatctcaaa ctcgccgcgg atgcggctca
     2581 gacagtgaga tttttctgaa caacgcagat ttccaggcac taagagttac tacgactcct
     2641 gcaaatgcac ccgaaaacaa ataaatttcc gagctgtgta ttggcgaata cagggtgggg
     2701 cggcgggttt gatgtgacag atgtaaatga tgttagggtc aaaaggtatt ttgaccctga
     2761 tatctaaata tagtaaaaaa cgccctgggc tgtttgccca gggcgaaaaa taatcttccg
     2821 cggtaccacc tgtattcaga gtctggctct gcactttgtc agtactgata tactgtgttc
     2881 ctgtaacgtg gaactgacgt tgaagcctac ttggcatgtc tgttcagatc tgtggatcag
     2941 acgggatatg cggttgggtt cactgctcgg gggctacttc tacaactcgt ttgcggaagc
     3001 tcgcaccgac cgcttcctct ctgtgctttt cggggttgtg tactcctccc tgtcatggca
     3061 tttggctgat agatagagat atttactgtc cggatagggt ggacaattgt tttcttgggt
     3121 tacattatac atttggagag tggaaattgt caacggggtt ttggataatt gttataaaat
     3181 ttgtgttccg gaatgaattt tgaatacgtt gctgagaacg gagtaaacag taatggaatt
     3241 gacatatttt tatattgctg atataaaaaa gaaataatac agttgtttaa ccgaactgcg
     3301 gagcagttat tcggttatga gcaagtagcg aagcggattg cgaatatccg cttgacaagg
     3361 aggggacata tggattattt atcaaacaat gtggcggtga atctgaagag aatccggaaa
     3421 tccaagagta tgagtcttga tcaggtgtct gagcagacgg gggtgagtaa gagtatgctg
     3481 gctcagattg agagagggac tgccaatcct tctctgggtg tgctgggaaa gatcacaagt
     3541 ggtctgagga tagagtttca ggagttgata cagccgccga gagtggactg ttgtctggtg
     3601 acaccggcag agctggttcc caccaaagag gtagcaggac agtacaaggt atggacctgt
     3661 ctgccttatg aggatacacg tctggtggag gtgtatcgga tcgaggtgga accgggtggt
     3721 gtttatatca gtggcagcca tggggagaag acaagagaat atctggctgt tatggagggt
     3781 gtgcttactg tggaatgtca tggcgagaag tatgaaatcc acagagatca ggtgtttaag
     3841 tttgaaacgg atcaggagca tgtctatcgg aacacaggga aggagaaagc ctgctgtacc
     3901 tgtttctttc tggattatca ttgatacagt tgtatcaggg attctgtcgc tgaagcaacc
     3961 cgccacaggc ggagaatcct gtttgcagga ttatttcctg tgtgattgct ggaattacca
     4021 tagtctgaaa ctgcgtagtg gagcaggtga ttttatccga agtatgagta tgaaatgtac
     4081 aatataatgc acaaaataat gaaaaagata cacttgaaaa tgaatatctg aaaagaaagg
     4141 atgtatgtaa tggtttgtca gtctgctatt tcatgaagag gctgtgttgt tatgaattgt
     4201 tgagaaacct ttataatatc gcacgaatat gcaggaaata ttggatgtac aataatgaga
     4261 acacagagtt ttctgtaaaa aaatataaat gatcaaaaaa acatgttgac aaatcataag
     4321 ggcagtgata ttgtaaggat gtacaaaata atacacagaa aaagttaagc aaaggcgctt
     4381 acccatacgg gtcagtttgt ctttgctttt ttttatctta aggatgcagg aggacacagc
     4441 tatgaaatta aaagacacag gattaacttt tcaggacatt aaggacaaag taaacaagta
     4501 catgatcgag acttatgaga gatttgattt ccttgcagag acagcagagg gcatgtacat
     4561 ttatgatgag aataaaacgc catatcttga tttttacgct ggtattgcag taaacagcgc
     4621 aggaaactgt aatccgaagg ttgtagctgc tgcaaaggat cagttagatg atatcatgca
     4681 tacattcaac tatccataca caatcccgca ggcgctgctt gctgagaagg tctgtgagac
     4741 aatcggaatg gacaagattt tctatcagaa ctcaggtaca gaggctaacg aggcaatgat
     4801 caaaatggcc cgtaaatatg gtattgaaaa atatggtcca aaccgttatc atatcgtaac
     4861 tgcaaagatg ggattccatg gaagaacctt tggtgccatg tctgcaacag gtcagccggg
     4921 taatggatgc caggttggat tcggacctat gacttatggt ttctcctatg caccgtacaa
     4981 tgaccttcag gctttcaagg atgcatgtac agagaacaca attgccatta tggttgagcc
     5041 tgtacagggc gagggtggcg tacatcctgc aacaatggaa ttcatgcagg gacttcgtaa
     5101 attctgtgat gagaacgata tgcttcttct gatcgatgaa gtacagacag gatggtgcag
     5161 aacaggtgct gttatgtcct atatgaatta tggtatcaaa ccggatatcg tatctatggc
     5221 aaaggctctg ggcggtggaa tgccgatcgg tgccatctgt gcaacagcag aggttgcaaa
     5281 agctttcaca gcaggttccc atggaactac attcggcgga catccggtaa gctgtgcagc
     5341 tgcactggct gaggtgaatg agcttctgga cagagatttg gctggaaatg caaagaaggt
     5401 tggcgattac tttgcagcta agcttgagaa gcttcctcat gtaaaagaag taagacatca
     5461 gggacttctg gtaggtgtgg aatttgatga tactatcggc ggagtggatg taaaacatgg
     5521 ttgtcttgac agacatcttc tgatcacagc tatcggagcg catatcatcc gtatgatccc
     5581 accgcttatt gttacagaag aagagtgcga caaagctgta gcaatcatcg aagatacaat
     5641 taaatctctg gaaaaataaa aatccggcaa cggagtgata cagtaaggac aagggcgtca
     5701 cgaattatat tcgtgcgccc ttttatgata tgatatcagg gtcaaaaaat caaaaagtcg
     5761 ttcgtgcctg cacgataaga cttttgaact tgggacctgc caaatatgag aaagtagcga
     5821 tttacatagc aaatcagcgg atttcgaatg tttgagaatc tgataaaaat ttgagtgtga
     5881 gagggaagag catgaaacat ctggtaatta cgattggctg cgaatatgga gccaagggca
     5941 atgccatcgg taagaagatt gcacaggatc tggggattaa gttttatgat cgtgatcttg
     6001 tggatgagat tatcaaagag gtaggcatcc ctacagacat tatggacaga gtagaggaag
     6061 gcggaaccat cgcaggtaaa ggtgcacagg gtgatgtgag aggttccttt tccaaatatg
     6121 cggatctgac agaccgcgcc attcatgtac agaagcagat tatccggaag ctggctcaga
     6181 aagaagcctg cgtgatcata ggacggtctg cagattatat tctgaaagat acagaaggaa
     6241 tccagctggt gagagcattt atttatgcac ctaatgatgt tcgcgtccac aacattatgg
     6301 aaagccataa tctttcggaa aaggatgcaa agcttctgct ggatgagaag gataaacgtt
     6361 atcataagag acatctggca ctgacaggaa gtaaccgcgg tgacagacat aacagggata
     6421 ttcttattaa cagtgatttt ctgggaattc agggaacagc agaatatctg gaagatctga
     6481 tcgcaaaaaa atacggaaaa aaggaggcct gacctatgga acaaaaaaca tcagaatttg
     6541 acaaagtact tggtgcatgg gacatacttg taattgcatt tggcgccatg atcggctggg
     6601 gctgggtagt ttcttccggt aactggattg aatccggtgg tgtgcttggt gcagctattg
     6661 catttgcaat cggtggaatc atgatcttct ttgtaggtct gacttacgca gagcttacag
     6721 cagccatgcc tcagtgtggt ggtgagcacg tattcagcta cagggcaatg ggttctacag
     6781 gttcttttat ctgtacctgg gcgatcattc ttggatatgt aagtgttgcc tgctttgagg
     6841 catgtgcatt tcccacaatc atcacttatc tgtggccagg gttcctgaaa ggatatctct
     6901 atacagttgc aggctttgat gtttatgcat cctggctgat cgtggcaatt gtgattgctt
     6961 ttcttattat gataatcaac attaatggag caaaaactgc agcagttttg cagactgttc
     7021 ttacctgtat tatcggcggt gccggaatta ttctgatcgt ggcttctgtg gttacaggaa
     7081 gtgtggataa ccttcaggga cagatgtttg ttggaaacgg taccggtgaa gcaatgaaaa
     7141 gtattattaa ggttgcagtt atcactccgt ttttctttat tggttttgat gttatcccac
     7201 aggcagcaga ggagattaat gttccgctga aaaaaatcgg taaaatgatg atcctctctg
     7261 ttgtgctggc tgttgtattt tacgcactgg ttattcttgc agtaggttat atcctgaatc
     7321 cggcagagat tattgagtct cagcagggaa caggacttgt aacagcagat gccatggcca
     7381 aggctttcgg gacaaagatt atggccaagg ttatcattgt aggtggaatg tgtggtatta
     7441 ttacatcatg gaactccttc ctccttggcg gttcccgtgc catgtactct atggcagaat
     7501 cctacatgat tcctccgttt tttgcaaagc ttcatccgaa gcacaaaact ccggttaatt
     7561 ctctgtatct gatcggtgcc ctgactatgc tggctccttt tgcaggaaga acaatgatgg
     7621 tctggatctg tgatgcaggt aacttcggat gctgccttgc atactgtatg gtctctgtct
     7681 ctttcctgat ccttcgtaaa aaggaaccgg atatggcaag accttacaaa gtaggccact
     7741 acaaatttgt aggttttatg gcagtagtca tgtcagggct gatgcttctg gtttactgta
     7801 ttccgggttc cggtggaagt ctggtatttc aggaatggct tatggtaggt agctggagtt
     7861 tacttggagt tgtattttat gcgatctgta aacgtaaata taaagaagac tttggtaaac
     7921 ttattgaact gatctctgat gaggatgcag caagtcttat gccggaggct gatgatgaag
     7981 agcttgatgt ggtaatcgat gcggctattg acagggtgct ttcctctatg gcataacgct
     8041 ataaatgaca tgacaattat tttgggtaac agagttttga atttgtgcag ggtccctgca
     8101 cattgcaata ttgaaaaata caggaaaaga ggcagaaatt aatgaatcca tttgaatttt
     8161 ttattcctca gaatattaca gtcggtgcag gtactctggc gaagcttccg gaatgtgcca
     8221 aaaagcttgg aggttctcat gcaatgctga tctcaggacc aactctccgg aaaatgggag
     8281 ttgtggataa ggcggcggat tatctgaaag acgccggaat ggcagtggat atttttacag
     8341 atgtagaagc caatccgtct gtcaccacag tggaaaaagc gacagaagcg tataaggatt
     8401 ccggcgcaga ttttatcgtt gcgctgggcg gtggttctcc tatggatgtg gcaaaagcag
     8461 tgggagttac ggctaaatat ggcggcagta ttacagaata tgagggggca cataaggttc
     8521 ccggaaaaat tgttccgctg atcgcaatcc cgactactgc gggaaccggc tcagaggtta
     8581 cggcattttc tgttatcact gaccacagca gagattataa gctgacggta ttcagttatg
     8641 aacttcttcc tgcatatgca atcctggatc ctgagcttct cacttctgct ccggcatctg
     8701 tggcagcagc ctgcggaatc gatgcattta ttcatgcgga ggaggcttat gtttccacag
     8761 cagcatctcc gttttctgac gcaatggcag agaaagcaat ggagctgatc ggtggaaata
     8821 tccgccgttt tgtggcaaga cgtacagatc tggaggcagc agaagcaatg cttacaggct
     8881 ctctttttgc aggaatcgcc ttttcctttg caagacttgg aaatgtccat gccatgagtc
     8941 atccggtaag tgctttcttt aatgtggcac atggagtggc aaatgcagtt cttctccctg
     9001 tgattgcaga atataatgcg ctggcagatc atggcagata tctgaagatt tataattata
     9061 tcagtccgat ccctgcatat gaggatgaat tcgaaccact gatgctggtg gatgccatca
     9121 gggaattaaa cgaagatatc ggaatcccgg aagacctgac cacagccatc cgccaggcga
     9181 agaagggaga agagatttct gatgaggaga ttgaaagcaa gattgatgcc atggcagatg
     9241 atgctatgaa gagcggaaat attgcagtaa atccaagatc ctccagaaag caggatattg
     9301 tgaaactgta ttataaagct ttataagata aagaataatg cagtatttta tgtgattgct
     9361 acaggtagga tattgattaa aaatatctgt tcttataaaa aacgtgcaga aacatcgaag
     9421 tcgacagata acttcaggct tgaaggttta tctcgatttc aaaatgtatc tgcacgttat
     9481 ttttttgaga aatttccatt gtataacttg cctgatagaa agaaagatta tatagtatta
     9541 accaaaatat agtaaagtaa tgtgagtcaa aatattgatt attcaggagg attttatggc
     9601 aaagaagaaa atatatgcag tacgcaaggg acataaaaca ggactttttg ctacatgggc
     9661 ggagtgccag aaggcagtaa gcggatattc aggagctgag tttcggggat ttacagagaa
     9721 agaggaagca ttggcttttc tgaacatgga gacaacagga aatgtatccg gtgataaagc
     9781 aaaagaggcg gcaggaatcg tggaagtacc tgaaaatatg gtcattgctt atgtagatgg
     9841 aagtttcgag aaaagtattg gcagatatgc ctttggttgt gtgatcctta caccggatgg
     9901 acaggaaatc cgtaaatccg gcagcggcag tgattctgca ggagtcgcga tccgaaatgt
     9961 ggcaggagag atgcttggtt ccatgactgc agtaaactgg gccatagaaa acaaatatcc
    10021 agctgtggaa atccgctatg attacgaagg tgtagagaag tgggtaacag gtgtgtggag
    10081 agccaaaaca cctctgacca gcaaatacgc agcccatatg caggaagcag gaaagaaagt
    10141 acagatttct ttttgtaaaa tagcagccca tacaggcaat cactacaatg aagaggcaga
    10201 tcagctggct aagagggcgt tgcttaagac ggatgaagaa gtacgaatat aaaagttcat
    10261 attaaagaaa gtaagtatct gaaaagtaga aaaatatgtg ataaaaacac ctgcttgttg
    10321 atagctgata aaatatatca gcatcaatag caggtgtttt agggataaga ttgaataatt
    10381 gtgaatctgc catctgatga gaatacaaat tcatcttaac agagttattt caagtgtttt
    10441 atcctgtttt cactggtatt ggaccacata gtatattgtt tacaatttct aaaatgttta
    10501 tcacagtaag aattgaaaga agcctggctt acatttttca tatgctgttc atctttaccg
    10561 gtttgaaaac cagcaacaga acagtatgcc cttgatgtgc tgacaagttt agaaccggac
    10621 aaagtccata atgcagaacc ggaaccacct actccgttgg tccaccagct tatatgtatt
    10681 ccattgtagt gagtgttata ctgtaaaatt tgataattca tcccttttcc ggaacactga
    10741 tcggcataga ttactttgcc attttttatg gtatatacag aataatctac aataactcca
    10801 cggttgcttg atacaatcag atcaggggtt ccatttctgt caatatccat tagatagaaa
    10861 cactttccgc cagactggag cagaaccttt tcatataagg ctctttgatc ttttatttta
    10921 atctgacatt tcagtttttt agagccgatt ttggctgtaa ttgttgcggt acctgttttc
    10981 tttgctttta cttttccaga agaaacagat gcaactttac tgtcagtgct ggaccaggta
    11041 acttttttgt ttgtcccgct taccttgagg tgataaacac caccaacatt cattgtcagt
    11101 ttagttttat tcagttttac ggaagctgcc tgagcagtac gtggaatgat tattagagaa
    11161 ataaccatta atactgcgat aataaatgag aagtgttttt ttaatagttt tttcattgac
    11221 tttcctccga acaatgagtt ttttgaagaa aattttttat tttactgtca cttttagttt
    11281 ttgagtaatt ccattacatt ttatcgagac agtagctgtt cctttttgtc tggcagtgat
    11341 ttttccttta gtgtttactg ttacgcattt agtatttgag cttttatatg tgattttacc
    11401 tgttggaact gcagaacagg agatggtata gctgcttcct tttttcagtg ttattgcttt
    11461 atttttcagg ttgagaactg gcttttttac agtaatttta caggaagcac ttttatttcc
    11521 cagagttact gtgacataag cggttcctgc acctttggct gttacttttc cagtggcgtt
    11581 gacctgaact acttttgtat ttgaactgtt ccaggttggc gttgatgtac tgccagagat
    11641 gactgatttt aatacagcag aatttttgcc tttgacagta taaagagtaa gttgcttttt
    11701 atttagtttg attgagtgat cttttacagg aacaaagttg agtccggcat tatttgcagc
    11761 tatttctacc gggctgttct taacaccgta gatggtatga agtgcttctg cacctataaa
    11821 cacccggcta tgcagattgg tagttgcagg aatctgcaag gtttctaatt gtgtagtgcc
    11881 atcaaaaaca ctggagccga tgtaggttac ttctggaccg atgattagtt tttttaagtt
    11941 tgtacagttt gcgaaagtaa atccttctat aactttgccg tgatactcgg cttcttccag
    12001 atttttacaa ttcaggaaga cactttgttc ctcatgtgtt acagaagggg gaacaataat
    12061 atggacaagt cctgtatcct taaaggaagc acttttcagg aatacaaggg ttgagggaaa
    12121 atcaatatgt cttagagctt tgcaaccttc aaaggcactg taactgattg tttgtgttcc
    12181 gaggggcaga gttacatctt ttaaattggt acagtttttg aacgatgcag agccaacata
    12241 ggtaaaaccc ttatggaaga taacttctga tagtgacgtg cagtttgcaa aactgtattc
    12301 gccaatttct tttactttag gtaaatccag atatgtcaga gaagtgcatc ctgcaaaagc
    12361 actgtcttct ataattttta tatttgaaga aatgtttacc ttagtaaggt tgtgacagcc
    12421 tgcgaatgta cgataataaa ttcggtcaag accctctgga taatgaatag acttaagatt
    12481 ttcgcactgt gcaaatacac tgattcccat ggatgtgatc gtatcaggca atattacaga
    12541 acacaggttt ttgttattag caaatgcaga ggattcaatt ttaacaacag gttttccatt
    12601 taagatagag gggactgtaa gatctgtatc agacccaaca tagcttataa ttgttgcttt
    12661 tccaagggag agtgtgtatt tatagccatc ctcataataa tagttggcgg cttttgctga
    12721 tacacagcta aaaagacaaa ggatgaaagc aaatagcaga acaagatgtt taaaccctgt
    12781 atttttattt ttcatagatg cctcctgtaa aatttaatcg aatcaatgaa tttatctgct
    12841 ttaattatga aaagtaataa acagtgagta gatgtttaat cgcaagttgg tgcacaggca
    12901 tatgtaaagc ctgttacaat gttatttttt atagtcaggg tgatgcttgc agcatttccc
    12961 caccagaata cagtcggatt gttaaagctt cttaggccat ttttattaag aatagcagta
    13021 gctttggaaa gtgtcattcc aagctgcatt ccaccgatac ctacaccgta atttccgcga
    13081 ttgcaaatat agacatattt ctgattcttg gaatattttg cattataatt tacaccaatg
    13141 atcatcttgt ttccggcagc atagaaagat ggataaccag aattgctttt tttatgcatt
    13201 ccacctattt tgttgataat agtagaatat tttccgacat atgatgggct taaaggcgga
    13261 agatttttca taaggttaag tactttgacc gttgttccgc tatatctgga aaagttactg
    13321 taaatagttt ttccatttac ggttttataa gcacgtactt tgtaatagta atgtcctgca
    13381 gaaagttttt tgtttgcata gctggtagta ttttttgttt ttatggtttt gattttacta
    13441 taatttcctt ttgcagaatt ggcacgccag atttcatacc cggatgcatt agaaacttta
    13501 gaccatttaa tggaaacact tgcttttttt gaagcagtaa ctttgatatt tgcaggtgct
    13561 ttaatagcag cggcctgtat ctgagtgcat gtaagaagca tcaacagaat acttgtgatt
    13621 acgagaaacc atttcttttt cttcatatta gttttcctcc tgagaaaata attttgtgaa
    13681 taatatttca taagtttgtt ttatcatagc ataaaaaatt aaaaagagtg tattaggcgt
    13741 agaaattaga cggaaaattc agagaatttt gtctaacttt tgtgcctaat caatctcgaa
    13801 agcagaaata tagtaaaata tgttataaat catttgaaca tggaggaaaa aacatgagcg
    13861 caaagttagt attaacagta aaggattcaa gcagaatggc aaaggattat tctatgagta
    13921 tgatggataa aatgtttcat ccgttaaaac ataataaaat cttgaattca aaggctaaaa
    13981 ttggcatatt aattgatgat gaggaagaag gaactttata tgaagcttcc aagactcctt
    14041 atgaaatcaa tctgcaacca ggtttccacc gcattactat gatagatccg gcgaaggaca
    14101 ataaaaaagg caatgttaat ttaataggat caataatagg agttgttgaa gggaatggga
    14161 tcgcagatac catggcaacc agtagatttg caaaatcaat ggcaggagca atgtttaaaa
    14221 ccggagatgg atatctggat ctgaatttaa aggatgggga tattatcaag gttcaatgtc
    14281 aggccggaat tggcgggaaa gtttcaataa agatattaaa atagaaaacg tagagggaaa
    14341 atgatatgga atttcctatt tatactccgt gggaaaatct tgatgcccaa acaatacaaa
    14401 aagtaataaa ttcaggaatt aattacagaa cttattgtga cgaaaagcca tgggatgttt
    14461 cttttgagat agattttttg ccaaaagaag agcttataat agttgttctg attgaacatg
    14521 gacgtcgtaa aggtggagtt agtgtacaga aaacaagtga acgaacagaa atttcgccgt
    14581 atagtaaaga agagcaggca gaaatgctaa aagcttataa tgagaaaatt gacagatatg
    14641 aaacgtggaa tgcattgttc acagaaccta cgacaggatt gtttggaaat aatgtgtatg
    14701 aatcatacat ggattacatg tattcctggg aacactggag tgatagaata tttttgtcag
    14761 attattatga agaacaatta tattcggtgc agtcagatac ctatgttact gtaaagagca
    14821 ctcaggaagg atatgattgt atctatgaac tggcacaagt gaaggtgaaa gagcatattt
    14881 tggaaggcat atgctggaag tcatttccca agctgatatt ttccagagga gataaatcag
    14941 acgctccgta taaagatgtg tataatcgtc tggaaatact gacaggagca gaatatttaa
    15001 ttgtaccggc gctgattgaa ataaaagaaa aatatgaaat tacagcagtt tcagaaaaat
    15061 tggactgtcc gcagatgcgg tttcgcggaa tgactatgga agaaactgta aaacaggctg
    15121 tttttgaaaa tatgtttgga gaatttttac agggaagtag attttgcaga gaaaatacaa
    15181 ataagaaatg cctcattgca gaggaacaga aagaaatatt tgcttccgag tttcttgaat
    15241 ctcagaaata tcctgaatta ttgatgaatg cagtaaaaaa agcagatttt cattgtatgg
    15301 cttttaaagt tcttggaatt ttgaatagcc catatatgca gacatatgat aaaatagaaa
    15361 tgttaagaag ctgtatggct attagtaata gtgcggaaaa atccagggaa tggaagaatg
    15421 catatcaaaa tctgatatgg gttatgatca aaaaactgga aatggatgat tcacagggga
    15481 acaatctgga agttgtcagt gaattacaga aatttgtgga ataccaacag ggagattttg
    15541 aaaaagaaca gaagggaaaa tccagagaag aaacagcaga aattttcttg atgaatgaac
    15601 tcataagaat gttggcatgt atttctattg taacagtaaa gaagattcag ggacaggaa
//
