LOCUS       gnlProkkaGEFAEFBC_235  15478 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|GEFAEFBC_235.
ACCESSION   gnlProkkaGEFAEFBC_235
VERSION     gnlProkkaGEFAEFBC_235
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2024-11-17 05:31:04
            Original ID  :: gnl|Prokka|GEFAEFBC_235
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 15478
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..15478
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="True"
                     /core_location="[4609:5478]"
                     /cutoff="20000"
                     /detection_rule="(TIGR04223 or AgrB)"
                     /neighbourhood="10000"
                     /product="cyclic-lactone-autoinducer"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      4610..5478
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(TIGR04223 or AgrB)"
                     /neighbourhood="10000"
                     /product="cyclic-lactone-autoinducer"
                     /protocluster_number="1"
     cand_cluster    1..15478
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(TIGR04223 or AgrB)"
                     /kind="single"
                     /product="cyclic-lactone-autoinducer"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..15478
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="cyclic-lactone-autoinducer"
                     /region_number="1"
                     /rules="(TIGR04223 or AgrB)"
                     /tool="antismash"
     CDS             complement(2..70)
                     /locus_tag="ctg154_1"
                     /transl_table=11
                     /translation="MAVAKEQIRQIISENNINSVADI"
     CDS             complement(277..465)
                     /locus_tag="ctg154_2"
                     /transl_table=11
                     /translation="MIIPYETFKENKRFKESIDNAQNETDILLYNAAKEYSNSVRKRAK
                     AVTDIIMERIEKEIKNS"
     CDS             complement(491..1135)
                     /gene_functions="transport (smcogs) SMCOG1000:ABC
                     transporter ATP-binding protein (Score: 162.4; E-value:
                     2.3e-49)"
                     /gene_kind="transport"
                     /locus_tag="ctg154_3"
                     /transl_table=11
                     /translation="MEKQRIEVNHVFKSFKEKEVLKDVSLTCESGKIYGIVGHNGSGKT
                     VLFKCICGFFYCDRGEIRVNGKCMGKDADMLQNAGIIIEEPGFLRQWSGFHNLEFLYTI
                     RNKLNKKYMYSVLEKVGLEPRSKIPVGKYSLGMRQRLAIGQAIMENPDILILDEPMNGL
                     DKNGVQEMRGLFEQMKNEGKLIILASHNREDIDVLCDEVYEMENGILKKRR"
     CDS             complement(1160..2038)
                     /locus_tag="ctg154_4"
                     /transl_table=11
                     /translation="MKTLKYIMKTSAQKIFNVKFATFCAAFLILSWTYDQPYLQFVKEK
                     NYPISWCIFPFYMSSFGILSIFYVGIVYIHSDVPFMQHINMYQVIRTGRERWALSQIAG
                     ILIRSFFAVILSAIAAVLPFWGHIEFSTDWGKVIKTLASQRADEGFGFGMGQMLDFRFH
                     YGILGKFTPVQLMIITVLICTLICTFLGILMFLISLYAGKILAVAVTMMSVVALFIVEN
                     IYGEWKLIVAHVVPTYWAEVALSATPVSGRYRIPSLTYIFTFLIVAVVFMSVIIFCKVK
                     HTEFHWENEDA"
     CDS             complement(2054..2833)
                     /locus_tag="ctg154_5"
                     /transl_table=11
                     /translation="MIILQCFINYLRTDFRRLGKSYRWLAGIVGVVAILFFSLESVLFQ
                     KGLENGNVLSTYVYSTNMTGFLIAYSFCAFPFAGVYPEEQEHKYIRYNVIRGSLKSYVL
                     SKTTVIYISSLSIMILGSVLFLFLCRTYVPWTDWSIDSYGIELNGCYGSILEEGHVILY
                     CTLYALNLGLIAGALSNMAALCSVFISNTVLVLVFPVLAFRVLVSVNIADYNIYAFYAY
                     TKIFASDGVNLLFLTVISVGISALSAAGCYWGLKKKM"
     CDS             complement(2873..3964)
                     /locus_tag="ctg154_6"
                     /transl_table=11
                     /translation="MRKGLRQAMIVLGICMCLGGCEKETEAKTEPEGETVQSEDGDFFP
                     ESYSEETEKVKFECVVNVPEKFEVTNFHAPIIKGVSNIDAETAYKKYVEGKVVTEEYHD
                     EPTIENEKGNDTYILEDGTVIGLSGVFLYNTPESSIYRQVVRMSERSAPKDNFKFASGD
                     DCTEQVKEELRSLGCPVDEYQFDWFSTSGEDYAILEKRALDDGMIDSQRAKQDGWTEAN
                     NSYEIYGWQLYEGLQVLPPWITSAMSRAFESYQKAPISAVYTKQGMLSLALTEAPCIFE
                     HSDETLEFLKFPEIADILEEKYSALLDDAVYTVTYAKLVLRTYFDEGQKLAAEPVWYFE
                     VTDGTSMEVALLNAVTGTEIFLN"
     CDS             complement(4021..4398)
                     /locus_tag="ctg154_7"
                     /transl_table=11
                     /translation="MRKIIKRTLCVLSATMCVLGTAATASADTVSFNVTIPGDPYSYAV
                     RKADTEQRFYVTGTSFNKSGTLRCRSGKAGQGTSSNSAYISSGSRASSASYTSYAAPNY
                     TYEMYATSGTSGLNVRGRFTP"
     CDS             complement(4610..5176)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     cyclic-lactone-autoinducer: AgrB"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg154_8"
                     /sec_met_domain="AgrB (E-value: 5.1e-38, bitscore: 121.0,
                     seeds: 181, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MEKHRKKFSIRLIEKIGHDEEEREIIQYGLHQGFLILLNLLTTVV
                     CGILWKELPFVLLVFWGIFFLRPYAGGYHADTELRCYFLSTAMMNMVVFLKKTIVLSNI
                     MFIIIWIITVIFIWIYAPVENTIHCLDEDARKKYANNTKKILLCNGIVMLVGIWVNQRI
                     VVDAIIWSQVMIAIAMIAGLWKYST"
     CDS             complement(5332..5478)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     cyclic-lactone-autoinducer: TIGR04223"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg154_9"
                     /sec_met_domain="TIGR04223 (E-value: 3.4e-09, bitscore:
                     27.5, seeds: 127, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKKDILKLGMKIVKNTAIKLAERDANTTCPYYGYQAELPCAVKKL
                     KKP"
     CDS             complement(5604..6887)
                     /locus_tag="ctg154_10"
                     /transl_table=11
                     /translation="MKFVMIAELLLILFSNGIRFYAVKRYIDFFAAREKCLWKYNWILY
                     TFACIGTYIVSIIFESPNLNIISNVIALFLLACPYKIKLSKKFLMTFIIYSINLLADII
                     VVQLLAGYVPGQRVGSAYQFITSLAILIPTAFFSEFTKKKTQDSLPLMNVFILGMIPLV
                     SIVCMHSIATLTENNKPVVLTVAFSLILINSFLFYLYYTLTQFYVAKMNEKKLEQIIDV
                     YAHQLDVVQESQEHIKKLRHDMKHHLIELSAMAQQDKNKDMMRYLEHMEKFMLNPAEKV
                     STGNKEIDGVLNYMLRRADELLKIVNLDIQIPKSLYRNNFNICVILGNLVDNAVRESSK
                     SDEKYLSISVRVQKDILIILIENSYSGSIVQKGNIFQTSQIDTSIHGLGLESVKQVVEA
                     CGGDIKIEYTEKRFWVQVLLYLSNIVEN"
     CDS             complement(6865..7644)
                     /locus_tag="ctg154_11"
                     /transl_table=11
                     /translation="MDKNNRVIYGIAGDGEIMRVVICDDEKVTCSEIEKMLSFFAFEKC
                     IKLEVDVFFDGDTLTEYLKKEKAPDILFLDIELPGMNGVEVGKYIRDILRNTDMFMIYI
                     SSKKEYALELFQNQPFDFLIKPIKKERLYHVMEKIFSIIGKNECNFEYKNQGNSYRIMY
                     KDILYFQSDGRKINIVMEKKIESFYGKLSEIEQMCPEGLFLRIHKSYLINMCHAKEITY
                     KWIKMINGDVLDISRSNRVAIRRKLMESMANEIRNDS"
     CDS             7726..8853
                     /locus_tag="ctg154_12"
                     /transl_table=11
                     /translation="MILHKKKDTLNRLCCIMKVTKQTLQHLRKKVPLTNTIHYSTFIYN
                     QLKKLNLCKSFSNRVIGHLMSILISIFISGYHGKTTDFSQNSSCPRTTIAHFLNSGKWD
                     DTLLENTLKSSVVEIIYSEAQRTGKPVFCIVDDTIASKTKPSSQAMHPIEDAYFHQSHL
                     KRKQDYDHQAVAVMLSCNGIVLNYAFVLYNKSISKIDIVQNIAKELPEPPVMSYFLCDC
                     WYVSEKIINTFVQKGFHTIGALKTNRLLYPSGMKKKLSELAAELSVTEKGFDPVTVKNR
                     KYYVCRWTIGVFFRQCKTRLALDTYQIRSSKGIQRYWLLMSMAHYICVISTGQYQSFQE
                     GYQLIRSTIQQEKYQYLFQCAKSCVDFEAFMKLAG"
     CDS             8995..9303
                     /locus_tag="ctg154_13"
                     /transl_table=11
                     /translation="MFKEAICLAKPNIELNAEKTTAMLYTLADKFLDRTELDEIKEVMR
                     MTRLGQMLMDEGMELKETDSIKKLMKNMNLTIDQAMNALEVPADKREKYRKTITPDN"
     CDS             complement(9380..10912)
                     /locus_tag="ctg154_14"
                     /transl_table=11
                     /translation="MDEYLKTLLEQIRCKKARPYVKQEFQDHIEDQIEANMQAGMDREQ
                     AEREAVRDMGDPVETGISLDSVHRPQVALKLLGIIVLISIAGVLIHAGIAGKISENAAA
                     GSDRYVFHVVIGLAVMMILYLLDYTVLARSSKIIAVILLFSCLVTLLGGYQLNGARCFI
                     VLPGGRGISMQTLMLFYVPIYGAILYKYHGWGYKGLIRAIIWMFAPVILVYAMPALMTA
                     CVMLVSMLVMLTIAIQKNWFTVRKRRAICGIWAGFLAMPVAAFLIRYLRSSLTKYQIAR
                     LQAVFSGGGEEDYFTEMLHSFWQQNKWIGKSESDVMGNLPAFNADYILTYLSSVYGTIA
                     AIFLCCVLAVLIFAVFNTAMRQKNQLGMMMGCGCGIVFLINFFINILENLGIFPQSVTF
                     LPFLSAGGSCIIVSYGLMGIVLSTYRYKNIYPRHLKIGFKFDKTKARKALYVSKMSMCI
                     WTGGTVVVMCVAIYWDLCKSYMNIPFKIVTIVLTLLLVGNMRKIVQHNEMNR"
     CDS             complement(10916..11245)
                     /locus_tag="ctg154_15"
                     /transl_table=11
                     /translation="MAIEKSLVSGSMTMLILKLLSEKDMYGYEMIDTLRQKSQNVFELK
                     AGTLYPLLHSLEDKGFLTVYEQEAAGKTRKYYSLTRQGRGFLEKKVEEWKEYSAAVTNV
                     LVMEV"
     CDS             complement(11447..12346)
                     /locus_tag="ctg154_16"
                     /transl_table=11
                     /translation="MREKAYFHLPGLFEFYELYRMFLPLYREHREYFYDWCEIGSIYGA
                     PADCIWGGGRAGFGENDPEEVLELMQEYGISARLTFSNSLLRQEHLSDRKCNALCRLFE
                     RNREPQNGVIIYSELLLEYIKEQYPGLYFVSSTTKVLTDFTQLEEEIWRKDFRYVVPDF
                     RLNKAFDRLNTLSQPEKDKVEFLCNECCWAGCRDRKVCYETVSRKNLGENCLEHYCKAP
                     EGERGYLFSKAIENPGFIGINDIRDIYLPMEFSNFKIEGRGLGSALILEFLLYYMTRPE
                     YQIHVREKIYLDSMLDLF"
     CDS             complement(12346..12561)
                     /locus_tag="ctg154_17"
                     /transl_table=11
                     /translation="MSKVVKLSSVMEREEKLKEIYEGLEEIKDQLTALIDEYEEEETHT
                     GKADELIEALDALEDASETIEDVLEN"
     CDS             12719..12892
                     /locus_tag="ctg154_18"
                     /transl_table=11
                     /translation="MLVCDYIVESIDGDYAHLRRTDLPEEELKLVARALLPFDITEGCR
                     LHYEMMQYSIID"
     CDS             complement(13000..13395)
                     /locus_tag="ctg154_19"
                     /transl_table=11
                     /translation="MLEIDAFFMNEDRHTNNIAVIYNEKTQKYELSPFFDQGLCMFADI
                     NQDYPIDQSLEYCLEKIEAKPFSSDFDIQLDAAEELYGIQIGFQFTFKDIQIYLQKNSE
                     NYPREVIRRVEQLLRRQMRKYGYLMKK"
     CDS             complement(13422..13817)
                     /locus_tag="ctg154_20"
                     /transl_table=11
                     /translation="MEIRNFDAYFPLHKSGHTSKGDQLKWKIDDRWYKADYMGYEGLSE
                     VLVSDLLQKSTCPFPFVEYEAAVIEYNGKIFQGCSSLDFLKANQILIPLEKLYRRYTGE
                     SLAVKLSDFADVSERIQYLVTQVKLLK"
     CDS             complement(13824..14447)
                     /locus_tag="ctg154_21"
                     /transl_table=11
                     /translation="MNFKDQIQQIFGTTDIHELKQISRDADNYRCLNADMNNSIISEKK
                     KNTGRKNSFTEEQLAHILALQDRGEKITDIARQYHVSRQTIYSQIKRAYNFSDDPDVKM
                     RMNFMNHDDLCTTIDIDFRHEKIKIKNYTDQIIFRAFGVVTDPDWADFEYFLEERCFPR
                     TRDHRKDILREMGLPFYDPLLIIEKTQGRMSDDHQWIMILKKEG"
     CDS             complement(14604..15158)
                     /locus_tag="ctg154_22"
                     /transl_table=11
                     /translation="MKAAVFFPGIGYHCDKPLLYYSRKLSQECGYEETIALSYTYDGGN
                     IRGNEEKMQQAFESLYEQAEKSLSAIDFDKYDEILFVAKSVGTIIASAYAEKHSIRCRQ
                     ILYTPLKYTYNFVHRDAIAFIGTSDPWSIVSEVQALSQKQQVPMYTYENANHSLETTDT
                     LENLKILQDVMGKTKGFLKRK"
ORIGIN
        1 atatatctgc aacgctatta atgttgtttt ctgagatgat ctgtcgaatt tgttcttttg
       61 caactgccat aaaaaatact ccttttcgat aagaattgtc atatctaaat tcttaccaaa
      121 aaggagttat tttttaccaa aaacacaaac tattttacac taccagcttt tacggaagat
      181 gattactcag ctctttccct gacaccattg atgtccggaa aaatgacccg caaggatata
      241 taatggtatc attttgacag atgccactta ttttgtttaa ctgttcttga tctctttttc
      301 aattcgttcc atgattatat ccgttaccgc ttttgccctt ttcctcacac tattactata
      361 ttctttagcc gcattataca acaatatatc tgtctcattc tgggcattat ctatactttc
      421 tttaaatctt ttgttttcct taaaagtttc atatggtatt atcatactaa cctccaacta
      481 tatcttttaa ttatcttcgt tttttcaata taccattttc catttcatat acttcatcac
      541 acaacacatc aatatcctct ctattatggc ttgccaggat aatcagtttt ccctcgtttt
      601 tcatctgctc aaacagtccc ctcatttcct gtaccccatt tttatctaaa ccgttcatag
      661 gttcatccag tattaaaata tctggatttt ccataatcgc ctgaccgatt gctaaacgct
      721 gccgcatacc aagagaatat tttcctacag gaatttttga acgtggttca agtcccacct
      781 tttccagaac ggaatacatg tattttttat tcagtttatt tcggattgta tacagaaatt
      841 ccagattatg aaacccgctc cactggcgca aaaaacccgg ttcttctata ataattccgg
      901 cattctgcag catgtcggca tctttcccca tacatttccc atttactctg atttctcctc
      961 tgtcacagta aaaaaatccg cagatacatt tgaaaagtac ggttttgcca gacccgttat
     1021 gtcctacgat tccgtatatt tttccgcttt cacaggtcag cgatacatct tttaacactt
     1081 ctttttcctt aaagctttta aatacatgat ttacttcaat cctctgtttt tccatctgtc
     1141 ctgtcctcct gtctgtaagc tacgcgtcct cattttccca gtgaaactct gtatgtttta
     1201 ctttacagaa aattatcaca gacatgaaaa caaccgcaac aattaaaaat gtaaaaatat
     1261 atgtcaggga agggattcga taacgtccgc tgacaggcgt cgcgcttaat gccacctccg
     1321 cccagtatgt aggtacaaca tgcgccacaa tcagtttcca ttccccatat atattctcca
     1381 caataaataa tgcaaccaca ctcatcattg tcactgcgac tgcaaggatt ttaccggcat
     1441 acaaactgat aagaaacatc aaaatgccaa gaaacgtaca tatcaatgta catatcagga
     1501 cagtaattat cataagctgt accggcgtaa atttcccaag aatcccataa tggaagcgaa
     1561 aatcaagcat ttgtcccatt ccaaatccaa atccctcatc tgctctttgc gaagcgagcg
     1621 tttttataac ttttccccag tctgtcgaaa attctatatg tccccaaaac ggaagaacag
     1681 ctgcgattgc agacaggata actgcaaaaa aagaccttat caggataccg gcaatctggc
     1741 tgagtgccca gcgttccctc ccggtacgga ttacctgata catattaata tgctgcataa
     1801 atggaacatc agaatgaata taaacaattc ctacataaaa aatagataaa attccaaatg
     1861 aggacatata aaaaggaaaa atgcaccatg aaatcggata atttttttcc ttaacaaact
     1921 gtaaatatgg ctgatcatac gtccacgaca agattaaaaa cgccgcgcag aaagtcgcaa
     1981 atttaacatt aaatattttt tgcgcagaag ttttcattat gtattttaat gttttcatat
     2041 agtcctccct ccgctacatt ttctttttca gcccccaata gcaccccgcg gctgatagag
     2101 cggaaatgcc cactgatata accgtcagaa acaaaaggtt tactccgtca cttgcaaata
     2161 ttttcgtata cgcataaaaa gcgtagatat tgtaatcagc tatattcaca gataccagaa
     2221 cgcgaaatgc cagtaccgga aagacaagaa ccagcacagt atttgatata aacacagaac
     2281 ataaggcagc catattcgac aatgcccccg caataagccc cagattcaat gcgtacagcg
     2341 tacagtataa aattacatgt ccctcttcca gaatgcttcc ataacagccg tttaattcta
     2401 ttccatacga atctatactc cagtctgtcc acggaacata tgtacgacac aaaaacagaa
     2461 acaaaactga tcccaatatc ataatgctca gtgaactgat atagataacg gttgttttag
     2521 atagtacata tgactttaag cttcctctta tcacattgta acgaatatac ttatgctcct
     2581 gttcttccgg atatacccct gcaaatggaa aagcgcagaa agaatatgca atcagaaatc
     2641 ctgtcatatt tgtagaatac acataggtag acagtacgtt tccattttca agcccttttt
     2701 gaaacaacac gctttccaga gaaaaaaaca ggattgccac tacaccaaca attccagcca
     2761 gccatcgata actttttcca agccggcgaa aatctgtccg aaggtaattt ataaaacact
     2821 gcaaaattat cacactctct ttctcaggca aaatctggta tgacaagcgt tgctaattca
     2881 ggaaaatttc agttcctgta accgcattaa gcaaagcaac ctccatagaa gtaccgtctg
     2941 ttacttcaaa ataccagacc ggctctgccg ctaatttctg accctcatca aaataagtcc
     3001 gcaggactaa ttttgcataa gtcaccgtat aaacggcatc gtctaataaa gcactgtatt
     3061 tttcttccag tatatctgca atttcaggga acttcagaaa ctccagggtt tcatcagaat
     3121 gttcaaatat acatggcgct tctgtcagtg ccagactcaa cataccctgt tttgtgtaaa
     3181 cagcagatat gggcgctttc tgatagcttt caaacgcccg tgacatcgcg cttgttatcc
     3241 acggcggaag aacctgcagt ccctcataaa gctgccaccc atatatctca taagaattat
     3301 tggcttctgt ccagccgtcc tgttttgccc tttgactgtc aatcattccg tcatctaaag
     3361 ctcgcttctc caatattgca taatcttctc cgctggtaga gaaccagtca aactgatatt
     3421 catcaacagg gcagcccagt gatcttaatt cttcttttac ctgttctgtg caatcgtctc
     3481 ctgatgcaaa tttaaaatta tcttttggag cgctgcgttc gctcattctc actacctgtc
     3541 tgtatattga ggattcgggt gtattgtaca gaaacactcc cgataaccct atcactgttc
     3601 cgtcctccaa tatatacgta tcatttcctt tttcattttc aatagttggt tcgtcatgat
     3661 attcttctgt aactactttt ccctcaacat attttttgta agctgtttct gcatcaatgt
     3721 tagaaacacc ttttataata ggggcgtgga agttggtaac ttcaaatttc tccggaacgt
     3781 ttactacaca ctcaaatttc accttctctg tttcctctga atatgattcc ggaaaaaaat
     3841 ctccgtcttc gctctgtacc gtctctcctt ccggctctgt ttttgcctcc gtttcttttt
     3901 cacagccccc taaacacata catattccca gcactatcat tgcttgtctc aagccttttc
     3961 tcatatagtc ctccttgaaa aaacgaaggc ggatttctcc accttcatct acagttttat
     4021 ttacggtgtg aaacgtcccc taacattcaa tccacttgtt ccactggtag catacatctc
     4081 gtatgtataa ttaggcgctg cataagatgt gtagctggca gaggaagctc ttgaaccaga
     4141 agaaatatac gccgaattgg agcttgttcc ctgtcctgct tttccagatc tgcatctcaa
     4201 tgtaccgctt ttattaaacg atgttcctgt tacatagaat ctctgttctg tatccgcttt
     4261 ccttactgca taagagtatg gatcacccgg aatcgtcaca ttaaatgaaa ctgtatccgc
     4321 acttgctgta gctgctgtcc ccagcacaca cattgttgca cttaaaacgc aaagtgttct
     4381 tttaataatt tttctcataa atcatttccc ctttctaaaa aagtttttca gttattaaac
     4441 aacattggca ccaacttgtt tgttgaattt actatagcat agaattatct cttaaaacgc
     4501 accttgccaa aaactgtata taattgtgtc aaaaatggaa attctgtcaa gactaatgcc
     4561 tttttgtata ttcacacttt tttctttatt ctcctatata aattatttat taggtactat
     4621 atttccataa tccagctatc attgcaatcg caatcatcac ttgactccaa ataattgcat
     4681 ctacgacaat tctttggttt acccatattc ccactagcat tacgattcca ttacataaca
     4741 aaattttctt tgtattattc gcatactttt tgcgtgcatc ttcgtctaaa caatgaatag
     4801 tattttctac tggggcatat atccaaataa atataacagt aataatccat attattataa
     4861 acattatatt tgataaaact attgtttttt tcaaaaagac aaccatgttc atcattgctg
     4921 tcgatagaaa ataacaacgt aattctgtat ctgcatgata tcctccagca taaggtctca
     4981 aaaaaaatat cccccaaaat accaataata caaaaggcag ttctttccag agtattccac
     5041 aaactactgt tgtcaataaa ttaagtaata tcagaaaccc ctgatgcaat ccatattgga
     5101 taatttctcg ttcttcctca tcatgtccaa ttttttctat caatcgtatt gagaattttt
     5161 ttctatgctt ttccattaaa aacctcattt tcttcaaaaa cacagttgcc acaaactact
     5221 atgttttcat aagaaaactc tatagtctat ggcaacctga ttacttttat tgttcctaaa
     5281 aggaactata tacttccata ttttctttaa aaaatcaacc aatttacaaa atcacggttt
     5341 tttcagcttt ttgacggcac atggaagttc tgcctgataa ccgtaatacg gacatgttgt
     5401 atttgcatca cgctctgcta actttatagc agtatttttt actattttca tacccaattt
     5461 caaaatatct tttttcatgt tgcatcctcc taaacatata ttttttataa cataccataa
     5521 attctcttca tatgcctttt attgtcaaaa actgtatatt tttttgtcaa aattggaact
     5581 aaaaaagagc caagtggctc tttttagttc tctacaatat ttgacaaata taataaaacc
     5641 tgtacccaaa atcgtttttc cgtatattca atctttatat ctccaccaca tgcttctact
     5701 acctgtttca cactttccaa acctaacccg tgaatagatg tatcaatttg gctggtttga
     5761 aatatattac ctttttgcac aattgaacca ctataactat tttctatcaa aataatcagg
     5821 atatcttttt gcacacgcac actaatggat aaatactttt catcagattt actcgattcc
     5881 ctgaccgcat tatctaccaa atttcctaaa atcacacaaa tattaaaatt atttctgtat
     5941 agtgattttg gaatctgaat atccagattc acaattttca ataattcatc cgcacgcctg
     6001 agcatgtaat ttaaaacccc atcaatttct ttattccctg tcgaaacttt ttctgctgga
     6061 tttaacataa atttttccat gtgttctaaa tatctcatca tatccttatt cttatcctgc
     6121 tgtgccatag cagataattc tattaaatga tgcttcatat cgtgacgcaa ttttttaata
     6181 tgctcctgag attcctgcac cacatcaagc tgatgtgcat atacatcaat tatctgctcc
     6241 agtttcttct cattcatttt cgccacataa aattgggtta atgtgtaata taaataaaac
     6301 aaaaatgaat tgatgagtat caaactgaat gctactgtaa gaactacagg tttgttattt
     6361 tctgttaaag ttgcaatgct gtgcatacaa acaatgctaa ccaagggaat catacccaat
     6421 atgaatacat tcataagtgg tagagaatcc tgcgtttttt tctttgtaaa ttctgaaaaa
     6481 aaagcagttg gaattaaaat cgccaagcta gttataaatt gataagctga gcctactctt
     6541 tgtccgggaa catatcctgc caacagttga acaactataa tatctgctag taaattaata
     6601 gaatatataa taaatgtcat taggaatttt ttagacagct ttatcttata cgggcatgcc
     6661 agtagaaata aagcaatgac attcgaaatt atattcaaat ttggcgattc aaatataata
     6721 ctaacaatat aagtcccaat acatgcaaaa gtatatagaa tccaattata tttccataga
     6781 catttttctc tggcagcaaa aaaatctatg taccttttaa ctgcataaaa tcgaattcca
     6841 tttgaaaaca atataagcaa cagttcagct atcattacga atttcatttg ccatactctc
     6901 cattagtttt cttcttatag ccacacggtt cgatctgcta atatccaaca catctccgtt
     6961 tatcattttt atccatttat aagtaatttc tttcgcatgg cacatattga tcaaatatga
     7021 tttgtgaata cgcaaaaaca acccctctgg acacatctgt tcaatctcag ataacttacc
     7081 ataaaaactt tctattttct tttccattac aatattaatt tttcttccat cactttgaaa
     7141 atacaaaata tctttgtaca taattctgta actatttcct tgatttttat actcaaaatt
     7201 gcactcattt tttccaataa tactaaatat tttctccata acatgataca gccgttcttt
     7261 ttttattggt tttatcagaa aatcaaatgg ctggttttga aacagttcta aagcatattc
     7321 ctttttagaa gatatatata tcataaacat atctgtattc ctcaatatat ccctgatata
     7381 ttttccgacc tcaaccccat tcattcccgg aagttcaata tctaaaaaaa gaatgtctgg
     7441 agctttttct tttttcaaat attctgtcaa agtatctcca tcaaaaaaca cgtccacttc
     7501 caactttata catttttcga acgcaaaaaa actaagcatt ttctctatct ctgaacaagt
     7561 tactttctca tcatcgcata ttactactcg cattatttct ccatctcctg ctattccgta
     7621 tattactcta ttatttttat ccatgcaagc tactcctttc aatttttcat aaacttcatc
     7681 tttagaagta tgttagcaag aatataacta taaatgagca agttcgtgat tttgcataaa
     7741 aagaaagaca ccttaaatcg tttgtgttgt ataatgaaag tgaccaaaca aacattgcaa
     7801 catttacgaa agaaggtgcc tctcacaaat actatacatt attctacatt catatacaac
     7861 cagcttaaga aattaaattt atgcaaatct ttttcgaaca gagtgatcgg tcatctcatg
     7921 agtatcctga tcagtatctt tatctcaggt taccacggaa agactaccga cttttcacaa
     7981 aacagttcct gccccagaac taccatcgca catttcctca attctgggaa atgggatgat
     8041 accttacttg aaaatacttt aaaatcctcc gtagttgaaa ttatttattc agaagcacag
     8101 cgcaccggaa aacctgtttt ctgtattgtg gatgatacca tagcttcaaa gacaaagcct
     8161 tcgtcacagg ctatgcatcc aattgaagat gcgtatttcc accagtccca tttaaagaga
     8221 aaacaggatt atgaccatca ggcagttgct gttatgcttt cgtgcaatgg cattgtcctg
     8281 aactatgctt ttgtactgta caataaatcc atttccaaga ttgatattgt gcagaacatt
     8341 gcaaaggaac tgccagaacc tccagtcatg tcatatttcc tttgtgactg ctggtatgtt
     8401 tctgaaaaaa taatcaacac atttgtacag aaggggttcc ataccattgg agctttaaaa
     8461 acaaaccgcc tgctgtaccc gtcaggaatg aaaaagaagc tcagcgaact tgctgctgaa
     8521 ttatcggtaa cagagaaagg atttgaccct gtgacagtca aaaaccgaaa atattatgtg
     8581 tgccggtgga caataggggt atttttcaga caatgtaaaa cccgtctggc gttggatacc
     8641 tatcagatac gttcctcgaa aggaatccag aggtactggc tgttgatgtc aatggcacat
     8701 tatatctgtg ttataagcac tgggcaatat cagtctttcc aggaaggata tcaactgatt
     8761 cgcagtacca ttcagcagga aaagtatcaa tatttgtttc aatgtgcaaa atcctgtgtc
     8821 gattttgaag cgtttatgaa attagcagga tagttttgtg cattttttca aatttgctca
     8881 tttatagctt aataattaaa gcagaagcag gataacggtg aagcttttac tgaagatgat
     8941 tacgctgctc tttccctgac accattgatg tccggaaaaa tgagccgcaa ggatatgttt
     9001 aaagaagcaa tttgtctggc aaagcccaat attgagctga atgctgaaaa gacaactgcg
     9061 atgttgtata cactggctga caagttctta gacagaactg agttagacga aattaaggag
     9121 gtaatgcgca tgaccagact tggacagatg ttaatggatg agggcatgga actcaaagaa
     9181 accgactcca tcaaaaaact tatgaaaaat atgaacctga ccattgacca ggcaatgaac
     9241 gccctggaag ttccggcaga taaacgtgaa aaataccgca agacaatcac tcctgacaat
     9301 taatggataa aagtaccgcc atattgactt atcacaatca atatggcggt atctttctta
     9361 atacagtttc ttacattttc tatctgttca tttcattgtg ctgcacaatc tttctcatat
     9421 ttccaaccag aagcaatgtc agtacaatgg ttacgatttt aaacggaata ttcatataac
     9481 tcttacacaa atcccaatat atggcaacgc acataacaac aacagtgcct cctgtccata
     9541 tgcacatgga catttttgag acatacaggg cttttctcgc tttggtttta tcaaatttaa
     9601 aacctatttt cagatgccgt ggatagatat ttttatatct gtatgtactc agcacaatcc
     9661 ccatcagtcc ataggaaact ataatgcagc ttcctcctgc tgataaaaag ggaagaaatg
     9721 ttactgattg tggaaatata cccagatttt ccaggatatt tatgaaaaag tttataagaa
     9781 atacgattcc gcatccacat cccatcatca ttccaagctg attcttctgt cgcatggcag
     9841 tgttaaaaac tgcaaaaatc aaaactgcca gaacacagca taaaaatatg gctgcaattg
     9901 ttccatatac agatgacaga taggtcagaa tataatccgc attaaaggcc ggtagatttc
     9961 ccattacatc tgattcactt ttccctatcc atttattttg ctgccagaat gaatgcagca
    10021 tttcggtgaa ataatcctct tctccaccac ctgaaaaaac agcctgtaaa cgtgcgatct
    10081 gatattttgt cagactgctt ctcagatacc tgatcagaaa agctgccaca ggcatagcca
    10141 gaaagccagc ccagattcca cagatggctc tcctttttct cacagtaaac cagttctttt
    10201 gaattgcgat tgtcagcata accagcatag ataccaacat cacacaagct gtcataagcg
    10261 caggcatggc atagaccaat ataaccggtg caaacatcca tatgattgct cttatcaagc
    10321 ccttatatcc ccatccatga tatttataca aaattgctcc atatatggga acataaaaca
    10381 gcatcagagt ctgcatggat attcctcttc ctcccggcag tacaatgaag catcttgccc
    10441 catttaactg atagccaccc aacaaggtaa ccagacagga aaacagtaaa atgacagcaa
    10501 ttattttcga agatcttgcc agtacagtgt aatccagaag atataaaatc atcataactg
    10561 caagtccgat cacaacatgg aacacatatc tgtccgaacc ggccgcagcg ttctcactga
    10621 tttttccggc aatccctgca tgtatcaaaa cgcctgcaat gctgataaga acgattattc
    10681 ccagaagttt caatgcaacc tgaggcctgt ggacactgtc aagagagatt cctgtttcca
    10741 caggatctcc catatcccgg acagcttccc tctctgcctg ttcacgatcc atgcctgcct
    10801 gcatatttgc ctcgatctga tcttctatat gatcctgaaa ttcctgtttt acataaggcc
    10861 gcgctttttt acagcgaatc tgttccagta atgttttcag atattcgtcc atagatcaca
    10921 cctccattac aagcacgttg gtcactgctg cagaatactc tttccattcc tcaactttct
    10981 tttccagaaa tccccttccc tgtctggtca ggctgtaata ctttctggtc tttccggctg
    11041 cctcctgttc gtatactgtc agaaatccct tatcctccag actgtgcagt aatggataca
    11101 gagttcctgc tttcagttca aacacgttct gagatttctg tcgcagggta tcgatcatct
    11161 catatccata catatccttt tctgatagca atttcagtat aagcattgtc atactcccgg
    11221 aaaccagtga tttttcaata gccatagtat tcacctccca ttgtatagat tgtctatata
    11281 tcggttatct atataataaa ggaacctgta tactatgtca actgtttccg gaataatttt
    11341 gacaacttca ctgctatggc aaccgagttc tggtatctac atactttttc agacagaaaa
    11401 accaccgcat tgtcatatag taacacaatg cggtggtata aatctctcaa aacagatcca
    11461 gcatactgtc cagatagatt ttttctctga catgtatctg gtattccggt ctggtcatgt
    11521 aatagagcag aaattccagt atcagagcgc ttccgagtcc tcttccttct attttaaaat
    11581 ttgaaaattc cattggcaga tagatatccc ggatatcatt gattccaatg aaccccggat
    11641 tctctatagc ttttgaaaaa agatagcccc tctctccctc cggtgccttg cagtaatgct
    11701 ccaggcagtt ttcacccaga ttcttgcggc tgaccgtttc atagcagact tttctgtccc
    11761 tgcatccagc ccagcagcat tcattgcaga gaaattccac cttgtccttc tcaggctgag
    11821 acagtgtatt taacctatca aaagctttgt tcaaccggaa atccggcaca acatagcgga
    11881 aatcttttct ccagatttct tcctcaagct gtgtaaaatc tgtcagaacc ttggtagtgg
    11941 aggaaacaaa atagagtccc ggatactgct ccttaatata ttccaagagc aattctgaat
    12001 aaatgatcac gccgttttgc ggttctctgt ttctctcaaa caaccggcac agtgcattgc
    12061 attttctgtc tgaaaggtgc tcctggcgaa gcagggaatt gctgaaagtc agtcgggcag
    12121 aaatcccata ttcctgcatc agttcaagaa cctcctccgg gtcattctct ccgaagccag
    12181 ccctgcctcc accccagata cagtctgccg gagcaccata tatggagcct atttcacacc
    12241 agtcgtaaaa atattccctg tgttcccgat ataatggcaa aaacatccga tacagttcat
    12301 aaaactcaaa cagcccgggc aggtgaaaat atgctttctc cctcattaat tttccagcac
    12361 atcctctata gtttccgaag catcttcaag ggcatccagg gcttcgatca gttcatctgc
    12421 ttttcctgtg tgtgtctcct cttcttcata ctcatcgatc agtgctgtca gctgatcttt
    12481 tatctcttcc agaccttcat agatttcctt taatttttct tcccgttcca ttacggatga
    12541 aagctttaca actttagaca ttgtgatacc tcccatatgc attttcttta ggaaaaatta
    12601 taacactgcc ctctttttat gtctatataa tctgaaggca cttgtgatac ccgttttctc
    12661 tgtggtattc tatagatatg atcattgcgt tacgcaaaat ataaagtgga ggatttttat
    12721 gttagtttgt gattatattg tagaatctat tgacggtgac tatgcacatc ttcgcagaac
    12781 ggatctgcct gaagaggaat taaagctcgt agcgcgggca cttctgccct ttgacatcac
    12841 agaaggatgc agattacatt atgaaatgat gcagtatagt atcattgact gatttgacag
    12901 tctccgcctc acagccgtta caaaaagttt accagaaaag gcaggtaagt gactttttta
    12961 tcctttacct gcctgtaact tcacgttctc tctgtaatat cattttttca tcagataccc
    13021 atacttacgc atctgtcttc ttaacagctg ctccacgcgt cttattactt ccctaggata
    13081 attttccgaa ttcttctgta agtatatctg aatatctttg aatgtaaatt ggaaaccaat
    13141 ctgaatgcca tacagttctt ctgctgcatc caactgtata tcaaaatccg agctaaatgg
    13201 cttcgcctca attttttcca gacaatattc caatgactga tcaataggat aatcctgatt
    13261 tatgtcggca aacatacaaa gtccctgatc aaaaaaagga ctcagttcat atttttgtgt
    13321 tttttcatta taaatgaccg caatattgtt ggtatgtctg tcctcattca tgaaaaacgc
    13381 atctatttcc agcattgcag tcagatacgc tccaaaatta tctattttag taatttcacc
    13441 tgagttacca ggtactgaat gcgttctgaa acatccgcaa aatctgagag ctttactgcc
    13501 agactttcac ctgtatatcg acgatacaat ttttccagcg gaatcagaat ctgatttgct
    13561 ttcagaaaat ccaaactgga acagccctga aatattttcc cattatactc aattacagct
    13621 gcttcatact caacaaaagg gaaaggacag gtactcttct gcaaaaggtc agatacaaga
    13681 acttcagata aaccttcata tcccatataa tcagccttat accacctgtc atcaattttc
    13741 catttgagct gatctccctt ggaagtatga ccgctcttat gcaagggaaa atatgcatca
    13801 aaattgcgaa tttccatttt tgatcagccc tcctttttta gaatcataat ccattgatga
    13861 tcatctgaca tgcgcccctg tgttttttca ataattaata acggatcata aaatggaagc
    13921 cccatctctc tcagaatatc tttcctgtga tcgcgtgttc tgggaaaaca gcgttcttcc
    13981 agaaaatatt caaaatcagc ccaatccgga tcagttacaa ctccaaatgc ccggaaaata
    14041 atctgatctg tatagttttt aatcttaatt ttttcatgcc tgaaatcaat atctatcgtt
    14101 gtacacagat catcatgatt catgaaattc atacgcattt tcacatccgg atcatcagaa
    14161 aaattatagg ctcgctttat ctgactgtaa atcgtctgac gggaaacgtg atactgtctg
    14221 gcaatatctg taattttttc tccccggtcc tgcagtgcca aaatatgtgc cagctgttct
    14281 tctgtaaacg aatttttcct tccggtattt tttttctttt cagaaataat gctgttattc
    14341 atatcagcat tcaagcatct gtaattgtcg gcatctctgg atatctgctt cagttcatga
    14401 atatctgttg ttccaaaaat ctgctgtatc tggtctttaa aattcatatt aatatcacca
    14461 ccttcaaaga gacattatgg aaaccacttt cacacagaac agtttgtgta atcgagtata
    14521 gcatggagca aaaagaagtg tcaagaaata gtttcttgac acttctctgc acgcatctac
    14581 tcaatatgat tatatgcttt ttcttatttc cgcttcaaaa atcctttagt tttccccata
    14641 acatcctgga gaattttcag attttccagt gtatctgttg tttccagtga atggtttgca
    14701 ttttcataag tatacattgg cacctgctgt ttttgtgaaa gagcctgtac ttcagaaaca
    14761 atactccatg gatctgaagt tccgataaag gcaatggcat ctctatgaac aaaattatat
    14821 gtgtatttca atggtgtgta tagtatctgc cgacatctga tgctgtgttt ctctgcatat
    14881 gcagatgcta tgatcgtgcc tacgcttttt gcgacaaata atatttcatc atatttgtca
    14941 aagtcaatgg cagaaagact tttctctgcc tgttcataaa ggctttcgaa tgcctgctgc
    15001 attttttctt catttccccg gatatttccg ccatcataag tatagcttaa tgcaattgtt
    15061 tcttcatagc cgcattcctg cgacagcttt cgtgaataat acaaaagcgg cttgtcacaa
    15121 tgatacccga taccagggaa aaatactgct gccttcatgt tctgctctcc atttaatagc
    15181 tgctccatca tttttcatca gattgccaga agattcttaa ttgcttccat atagaccaga
    15241 actgcctctt ccatgccgga tacgaggata aattcatctg cactgtggat acgataatcg
    15301 attcccggct tctcaggtcc aaatgcaatg atatttttaa gagactttgc ataagtgccg
    15361 ccgccgatta ccattggttt gttctctgta tcacctgtta catctgtgta agctttatat
    15421 aaagcattta caagtgggga ttctcttggg aagaataagg catcaccaat tcccagaa
//
