LOCUS       c00063_gnlPro..        16795 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|DLDDNNCP_133.
ACCESSION   c00063_gnlPro..
VERSION     c00063_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-06 04:02:57
            Original ID  :: gnl|Prokka|DLDDNNCP_133
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 16795
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     CDS             1..66
                     /locus_tag="ctg63_1"
                     /transl_table=11
                     /translation="GTQERDAGIQDLRMEYQQIGL"
     protocluster    1..16795
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[5438:7690]"
                     /cutoff="10000"
                     /detection_rule="(Succ_DH_flav_C and FAD_binding_2 and
                     (Fer2_3 or Fer4_7 or SucD_FumR))"
                     /neighbourhood="10000"
                     /product="Fumarate2succinate"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      5439..7690
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(Succ_DH_flav_C and FAD_binding_2 and
                     (Fer2_3 or Fer4_7 or SucD_FumR))"
                     /neighbourhood="10000"
                     /product="Fumarate2succinate"
                     /protocluster_number="1"
     cand_cluster    1..16795
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(Succ_DH_flav_C and FAD_binding_2 and
                     (Fer2_3 or Fer4_7 or SucD_FumR))"
                     /kind="single"
                     /product="Fumarate2succinate"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..16795
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="Fumarate2succinate"
                     /region_number="1"
                     /rules="(Succ_DH_flav_C and FAD_binding_2 and (Fer2_3 or
                     Fer4_7 or SucD_FumR))"
                     /tool="gutsmash"
     CDS             17..325
                     /locus_tag="ctg63_2"
                     /transl_table=11
                     /translation="MRVSRICAWNTSRLAYDGSGAVTRDWENHSLCTFQTGKRYNCDLS
                     ASYNIGARYFIRELLKPLPATERSLLEAKVPPVKRRTSCVYADLRELHLQMEILKVA"
     CDS             1015..1452
                     /locus_tag="ctg63_3"
                     /transl_table=11
                     /translation="VATKVDKKNAIRQGITEAEIVYFQNLAGKTFLYVCGDEYFEVSFP
                     IDHFLHLTGVETRLSTKDFYKNAKKSILTNNQFYFDARHVYANAKRKLPCLKRLPELTN
                     EMVCVLKNMETMTITYKLSVTNLEFTGSVTRKPKRYTGKKD"
     CDS             1584..1943
                     /locus_tag="ctg63_4"
                     /transl_table=11
                     /translation="MPKTSYICNCDVIHEDIVNDVKSKMQPKDDYIQLASLFKLFGDGT
                     RVQILHALEQSEMCVCDLAVLLGVTKSAISHQLKALRLANLVKFRKEAQIVYYSLADDH
                     VKEIIDKGFEHLWQK"
     CDS             2003..4357
                     /locus_tag="ctg63_5"
                     /transl_table=11
                     /translation="MKRIFLLKGLDCPNCSAKIEKEVGELDGVQSSVVNLMKQTITVNV
                     TQTAADTIASQIETIVYSHEPDVEVQEETVMNVTKSYSLKGLDCPNCSAKIEKEVGELD
                     GVQSSVVNLMKQTLTINVAQTAADTIASQIETIVHSHEPDVEVSEIVQESYIPEKKQEA
                     NESYNNEDKKLTVRLATGAAIYAIGMALTVFAKVPLPIELAFLIVSYVILGGDVVWQAV
                     RNISKGRVFDEHFLMSVSTIGAFVIGEYPEAVAVMLFYQVGEFFQSLAVKRSRKSISDL
                     MDIRPDSATVRRNGELITISPENVSIGEIIIVKPGEKIPLDGVVLDGDSMLDTRALTGE
                     SVPRSVHKGDEALSGCMNQTGVLMIKTTKAFGESTASKIIDLVENASSRKAPTENFITT
                     FARYYTPVVVILAAFLAILPPIILGGGWTEWIRRGFVFLVVSCPCALVISIPLTFFGGI
                     GAASKRGVLVKGSNYLEALNNVSVIVFDKTGTLTKGVFNVTDILPANGFSKEQVLEYAA
                     EAESFSNHPIAKSILAAYGKEMDQSVIFDYKEISGYGISVMAGEKKVFAGNTKLMDTEC
                     IEYTTCEKAGTKVYLAVDGQYAGCILITDEVKPDSKKAISDLKHIGVEKTVMLTGDDEK
                     IGKSVAEELQLDEYYAQLLPDQKVEKVELLDSKKRPGSKLAFVGDGINDAPVLARADVG
                     IAMGGLGSDAAIEAADVVLMTDEPSKLVDAIEVAKATKQIVMQNIVIALGIKSVFLILG
                     ALGIAGMWEAVFGDVGVTIIAVLNAMRILKK"
     CDS             4374..4892
                     /locus_tag="ctg63_6"
                     /transl_table=11
                     /translation="VKRKLILLVVTIVFLVGFGVILHSPPSMIDAVTGATPKSKKAAQA
                     SAQLEGSYVLGINMMSDGLDNENTRNKLKELALDDSETNETDLMKTDISFRLYVSETDY
                     PLVSYAKKLCDRLKQAGFSVDLKEYSNTMMLSRVVSGKYDVFLASDDFIDVTTLTQMDY
                     MIMDSEEMR"
     CDS             4903..5442
                     /locus_tag="ctg63_7"
                     /transl_table=11
                     /translation="MRKWNTILSVLMLLIFMIHGIMGSFMLNGVGSSAGKLLAWIGVGI
                     LVVHTVIGVILTVQSLQTAKQSGKMYLKQNAIFWARRASGLAILILLFFHIGLFGKVQN
                     GTYILFPFTTVKMVTQLLFVAAIFVHIFINIRPLLVSLGIISYKERRGDIYLILSVLLL
                     FIAGAVIFYYIGWQYL"
     CDS             5439..6983
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Fumarate2succinate: Succ_DH_flav_C"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Fumarate2succinate: FAD_binding_2"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1027:FAD binding domain (Score: 270.5; E-value:
                     9.3e-83)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg63_8"
                     /sec_met_domain="FAD_binding_2 (E-value: 2.7e-83, bitscore:
                     270.5, seeds: 62, tool: rule-based-clusters)"
                     /sec_met_domain="Succ_DH_flav_C (E-value: 3.9e-17,
                     bitscore: 52.7, seeds: 739, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSKTIIIIGAGLAGLSAALQAAENGCNVKLVSSLPSERAQSVMAE
                     GGINAALNTKDENDSPEEHFTDTIKAACGLADPNAVWGMTQAAPELVHWLLKLGVKFNM
                     SGYDDVDLRNFGGQKKKRTAFAQSDTGKQIMTAMIDAVRRKEASGMVERFSHHSFLTLR
                     LCGNICCGCVIRDEYSQETVELPGDAVIVATGGMHGLFGNTTGSLSNTGEVTAELFRLG
                     VPLANSEMIQYHPTTVKCGGKRMLISEAARGEGGRLFAMKDGKQWYFMEEKYPELGNLM
                     PRDITAREIWKVSHESEVFLDMTEISEEIISNKLSGLADDCMTYLHKDIRKEPVSVLPG
                     IHYFMGGILVDEQHRTPIQNLYAAGECCAQYHGANRLGGNSLLGALYGGRVAAKSAREQ
                     ADVVDLSCATQIDFPPTSQISEIKQLNKVMQDTMGVVRNENTLLNGIQTVQALTGNLPL
                     LGMAVLKSALARKESRGAHWREDYPKSNDDDYLKTTVARFDGKQIQISFVPVPERR"
     CDS             6989..7690
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Fumarate2succinate: Fer2_3"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_4"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1052:Succinate dehydrogenase-2Fe-2S iron-sulfur
                     cluster binding domain (Score: 91.5; E-value: 1.1e-28)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg63_9"
                     /sec_met_domain="Fer2_3 (E-value: 3.2e-29, bitscore: 91.5,
                     seeds: 38, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_4 (E-value: 0.00075, bitscore: 10.5,
                     seeds: 79, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="LVYKIRIRRQESQKSDSYWQEFEFDGSKNSSVANVLKELNSRTPL
                     KDNSGNIVTPISWECSCMVRKCGACAMLINERPRLACSTFLHTLKGSTITLEPLSKFPL
                     VRDLIVDRSILFENLKKLNLWLESEAYMNRWTHEPRYQSARCLMCGCCLEVCPNFSANG
                     TFAGAVAAVNAFRILNEEQESTHLNEISAEYKKKYFEGCGKSLSCHDICPIGLPVEELL
                     VRSNAAAVWGK"
     CDS             7715..8458
                     /locus_tag="ctg63_10"
                     /transl_table=11
                     /translation="MYEENQKLKTWITPDLATEYLAGAVLLGAAPCTAMVFVWSTLTKG
                     NPAYTVVQVASNDIIILFAFVPIVKFLLGVSNVSVPFQTLFMSVVLFVVIPLAAGIITR
                     LLVVRKKGTEYFEQTFLHKFDSATTVGLLLTLILIFMFQGEVVLDNPLHIILIAVPLII
                     QTFFIFFLAFGVCRIIRLPYDIAAPAGMIGASNFFELAVAVAVALFGTSSPAALATTVG
                     VLTEVPVMLTLVKIANKLKEKFKYE"
     CDS             8451..8864
                     /locus_tag="ctg63_11"
                     /transl_table=11
                     /translation="MNKKKVAFICVHNSCRSQIAEALGKHLASDVFESYSAGTETKLQI
                     NQDAVRIMKELYGIDMEAEGQYSKLIDEIPVPDIAISMGCNVGCPFIERPFDDNWGLED
                     PTGKSDEEFKKVIDEIRMQIFILKQRLDEFEEN"
     CDS             9174..9413
                     /locus_tag="ctg63_12"
                     /transl_table=11
                     /translation="MRTIYAEYNINHDSIDVYTSAGYMLRIDCWEAEKNLKTTYGSECA
                     LTSLAVDEPLEYARLYLDGNLQMWVDTEDSLELY"
     CDS             9663..10352
                     /locus_tag="ctg63_13"
                     /transl_table=11
                     /translation="MKHILIVEDDNLLNKTLTYNLELDGYTITSVLNARTAAESLKTNI
                     FDLVLLDINLPDGNGYDLCRLIKPEHPDTVVIFLTANDQESNQIRGYEAGAVDYITKPF
                     SISALQRKIKAMFAMLEHHKPAKDIYEDGSLFLDFSEQFASLNGKPLALSAMEYKMLNL
                     FLKNPKQVLTRQQFLEKLWDVDEKYVDEHTLTTSISRIRSKIEADGDTYIKTVYGMGYQ
                     WTGGEKK"
     CDS             10349..11380
                     /locus_tag="ctg63_14"
                     /transl_table=11
                     /translation="MNLNNLSAKKICRLVSAGMVFSMLVITGIFGGIMQDIRIFIVGGT
                     LTLCAFFWIWLLVLIFGKRLSHFTSNLCRTLDNMIDGNEELQKSNDSETLFARINHRLI
                     RLYEIMQKNRHKVDMERQELQMLISDISHQVKTPVSNLQMVTDTLLTKPVSEEERMDFL
                     QGIRSQTDKLDFLFQALVKTSRLETGAIRLEKKDSSLFHTLAQAMSSIVYVAEKKEIAV
                     SVDCPENLIISHDSKWTSEALFNLLDNAVKYTPSGGKISVSVVQWEMYVEVKVTDTGKG
                     ISESNQAAIFRRFYREEEVHDQQGVGIGLYLAREIVTRQGGYIKVVSELGQGSEFSIML
                     PVR"
     CDS             11532..12197
                     /locus_tag="ctg63_15"
                     /transl_table=11
                     /translation="MSILQTIDLKKYYGTEPNITRALNGVNFTVEQGEFVAVVGTSGSG
                     KSTLLHMMGGLDTPTSGSVIVRGEELAKKNDDELTIFRRRNIGFIFQNYNLVPILNVYE
                     NIVLPVELDGDTVDQKFMDEVVYMLALEDKLENMPNNLSGGQQQRVAIARALITKPAII
                     LADEPTGNLDSKTSADVLGLLKHTSGEFNQTIVMITHNNEIAQLADRIVRIEDGKIVG"
     CDS             12212..14539
                     /locus_tag="ctg63_16"
                     /transl_table=11
                     /translation="MNYPFENDTSAVIKKLARKSVRFDKKKNLFCLSAIIVAVAMIMMS
                     LLTVQNIIYQNQKEIEGLHQGIFFDITQDSKEKLLANEEVKSVGLSCNIKTVKENSKEL
                     SLIYYDDDMLSLIPAFDGKYPEKASEIAVTDAFFASENKSPEINAIVQLNLDGTLKNYT
                     IVGIYHDKTSTAYPVFVSLEKCRELRGNNLLNGYVWLENADTLTKDEATEILSQISEET
                     GLNNWTVSSYYDYVNTTLSFSNYAVYGVVAAILFLAAALVIYSIFYISVGQKVAEFGQL
                     RTIGASKKQIYKIVLKQGYMLAVPGILIGSIMGTIISYCLQSKGWSVFAFIVSLCGACL
                     FGILLVYISVRKPAKIAANTSPISALKNPVGIVNYRTHKRHRITPVYLAKISFSRNRKK
                     SLLTILSLGLCGVIFFLAASYQSSFNAESMARYWDMKYGDFKISIDLENESENLDALLQ
                     KEYFSDYVKRVGDIEGVSNIFTYATVPVDFSTDNDISDSTLMLGYNEKDLASLNAAVLS
                     GNITDDTELVVSDPERIYDVYHWKPQIGDTVTFNFKNHSGKTITKAFKIGAITSSNDGM
                     GGYIFRMPENMLKELAGYDCTYAIEIQAEAEYQEIIEQELKLLVSDNRDVRLQTLQDFI
                     VEHQSDNRAGFTLAYAIAAILWIFAVINQINLTVTNLLSQKQEMGTLKSIGMTNKQLKQ
                     AFMMEGLFTTLIALLITAVVGIPGGYAIGIFLKNAGMSTGFVFPVVAFTLFAVAMFMLE
                     SLMTILLIHSWKKQSVIAIMRN"
     CDS             complement(14735..15700)
                     /locus_tag="ctg63_17"
                     /transl_table=11
                     /translation="MNESRESKNAEQLEELLLLTEEIQEELEQKEQLIVELKTQLSESL
                     TLNEKLNKENRAGNIQALKNDLKLADRALRIEKEKLRSANVMIEECQDKICYLTQERDY
                     ARTHQKIVEIPVEKPVLYEKCEACNRTAYQNAKAKYETQKERLAGQYKAKTVMFQTTLF
                     LLAWYSLTTTLFQAVQSDMFLVDCKSFFNDLASFIQIFVGWTIDAGHSAAQISTKIPNA
                     FIAGMVYWLLLILIVGICMAGTGMLAILIEIKVIELYKKNCWDVITLLMILTSVAIVIY
                     FGESIKKVLSVNLLLLFVLSQGAYVGIRCYLKVWLEKRPY"
     CDS             complement(15719..16078)
                     /locus_tag="ctg63_18"
                     /transl_table=11
                     /translation="MTLEESREIIPLMESMIGQIEEQQNLMAEMILEMQNRDTQLSLMQ
                     KQNQKLQKLNNELSELLNILPNTEELLSKMEEQKTKIELLENENQQWQKLAQKLNSENS
                     LLLKQNTELLNWNSR"
ORIGIN
        1 ggcacacagg aaagggatgc gggtatccag gatctgcgca tggaatacca gcagattggc
       61 ttatgatggt tccggggcgg taacacgtga ctgggaaaat cacagcctct gtactttcca
      121 gacaggaaaa cgatataatt gtgacctgtc agcatcctat aatatagggg cgagatattt
      181 tataagggaa cttttaaaac cccttccggc aacggaaagg tctttgctgg aggcaaaagt
      241 ccctcctgta aagcgtagaa cctcatgtgt ttatgctgac ttaagagaac ttcatctgca
      301 aatggagatc ttaaaagtag cataaacaca ggcagatata cagcggatta cctgtaatgt
      361 gggaacctgc cgtatccggc atggaaaaag cacataactg tgcagaccta agttacaggc
      421 gtatccgccg atattcagtc tgacgcctaa agcgtctgga agcacgtgac tttagccatg
      481 tgaggttcac gattatcgga aaatgcctgt aaacagcgta aatacagcat ttcaaggagt
      541 tttaagcaat gataagagtg ttatttgtct gccacggcaa tgtttaatgg atgccgtgaa
      601 agccttgatt ttattggatt tcttgggaat taaccaataa tttacacctt atttatacct
      661 ttggaagacc ggatcggaat aatataataa aatttgctaa tctgtgttga ttttttttat
      721 gattgagtat aataaaatca agaacagaaa tgttctcgat gtaagagcat cgttaaaagt
      781 tgggctgcag atggagcagg gtaaacttcc atctcattag atgtcttaac tgggcatcga
      841 gcctggtagc ttggataaag ctgtagtcca cgtgggggac ttaatgattt tcacgtcgtt
      901 atgggtatct taactgggta tcgaggctga caaccagcag aaaactcttt tacaaaagta
      961 attctcagaa aagtgtggtt taatgccaca ctcttttttg catgtgaggt ataagtggca
     1021 acaaaggtag ataagaaaaa cgcaatacga caaggtatta cagaggcgga aatcgtatat
     1081 ttccaaaatt tggcaggtaa aacatttctg tatgtttgtg gagatgaata ttttgaagtt
     1141 tcttttccaa tagatcactt tctacattta acaggagtgg agacaagact ttcgaccaag
     1201 gatttttata agaatgcaaa aaaatctatt cttacaaata atcagttcta ttttgacgca
     1261 agacatgtat atgcaaatgc caaaaggaaa cttccgtgtt taaaacgctt gccggaatta
     1321 acgaatgaaa tggtatgtgt tctaaaaaat atggaaacca tgacaattac atataaactc
     1381 agcgttacaa atttggaatt tacaggaagt gtgacaagaa agccaaaacg gtatactggg
     1441 aaaaaagatt aagaaaagaa taaagagctg gttttaattg taaaatttat ggggaactaa
     1501 catcagctta ttgacatgaa tttaaaaata agtataataa tagttgagta attgttcaac
     1561 tattattatt tggaggtgaa tatatgccaa aaacgtctta tatttgtaat tgcgatgtaa
     1621 ttcatgagga tattgtgaat gatgtgaaat ccaagatgca gccaaaagat gattatatcc
     1681 agttggcttc tttgtttaag ctatttggag atggaactag agtacaaatc ttacacgctc
     1741 tagaacagag tgagatgtgt gtatgtgatc ttgcagtgct actgggggta acaaaatctg
     1801 caatttcgca tcagttaaag gcattacgcc ttgcgaatct ggtaaaattc cgtaaagaag
     1861 cacagatagt ttactactca ctggcagatg atcatgtgaa agagattatt gacaagggat
     1921 ttgagcatct ttggcagaaa taatattttt taacattata gttgagtaat tgaacaatta
     1981 aacaaattat aaggagatta tcatgaaacg catatttcta ttaaaagggt tggactgtcc
     2041 aaattgttcc gcaaaaattg aaaaagaagt cggagagttg gatggagtgc aatcctcagt
     2101 ggtaaatctg atgaagcaga cgattacagt caatgttact cagacagccg cagatacgat
     2161 agccagtcag attgaaacga ttgtttatag tcatgagcca gatgtggaag ttcaggaaga
     2221 aaccgttatg aatgttacaa agagttattc gttaaaaggg ttggactgtc cgaattgttc
     2281 cgcaaaaatt gaaaaagaag tcggagagtt ggatggagtg caatcctcag tggtaaatct
     2341 gatgaagcag acgcttacaa tcaatgttgc tcagacagcc gcagatacga tagccagtca
     2401 gattgaaacg attgttcata gccatgagcc agatgtggaa gtttctgaaa ttgtacagga
     2461 atcttatata ccggaaaaaa agcaggaggc caatgaatcc tataacaatg aggataagaa
     2521 gttgacagtt cgtttagcga ctggtgcagc aatctatgcc attggtatgg cattgactgt
     2581 ttttgcgaaa gtgccactgc ctatcgagtt agcttttctc attgtttctt atgttattct
     2641 tggtggagat gttgtatggc aggctgtgag gaacatttca aaggggcgtg tatttgatga
     2701 acattttttg atgagtgttt ctacgattgg ggcttttgtc attggtgaat atccagaagc
     2761 agttgctgtt atgttattct atcaggtagg tgaatttttt cagtcattgg ctgttaagcg
     2821 ttccagaaaa tctatatcag acttaatgga tatacgtcca gattctgcta cagtaagaag
     2881 aaatggggaa ttgattacca tatctccaga aaatgtctcc attggtgaga ttattattgt
     2941 aaagcctggt gaaaaaattc cattagacgg tgtggtattg gatggagatt ctatgctgga
     3001 tacaagggcc ttaacaggag aatcagttcc gagaagtgtt cataaaggag acgaagcact
     3061 ttccggttgt atgaatcaga cgggtgtctt aatgattaag acaacaaaag catttggtga
     3121 atctacggct tcaaagatta ttgatcttgt ggaaaatgcg tcaagccgaa aagcaccaac
     3181 agaaaatttt attactacat ttgcacgtta ttatacacct gtggttgtaa tcttagcagc
     3241 ttttctggcg attctgccac cgatcattct tggcggaggc tggacagagt ggattcgcag
     3301 aggatttgtt ttccttgtgg tatcttgtcc atgtgcattg gttatttcaa tcccgctgac
     3361 tttcttcggc ggcattggtg cagcatctaa acgaggtgtt cttgtaaaag gaagcaatta
     3421 tttagaggca cttaataatg tcagcgttat tgtgttcgat aaaaccggaa cacttacaaa
     3481 aggtgttttc aatgtgacgg atattttgcc tgcaaatgga ttttcaaaag aacaggttct
     3541 ggagtatgcg gcagaggcag agagtttttc taaccatcct attgcaaaat ccattcttgc
     3601 tgcttatgga aaagaaatgg atcagtcagt gatttttgat tataaggaaa tttcaggata
     3661 tggaatcagt gtaatggcag gggaaaagaa agtttttgct ggcaatacga aacttatgga
     3721 tacagaatgt atagagtaca caacctgtga aaaagcaggt acaaaagttt atttggctgt
     3781 agatggtcaa tatgcaggat gtattttgat aacagatgaa gtgaagccgg acagtaaaaa
     3841 agcaatttct gacctgaaac atatcggcgt ggaaaaaaca gtcatgctta ccggtgatga
     3901 tgaaaaaatt gggaagtctg ttgcagaaga attgcagttg gatgaatatt atgcacagct
     3961 gcttcctgac caaaaagtgg aaaaggttga gcttttagat agtaaaaaga gaccgggaag
     4021 caaattggct tttgttggtg atggtatcaa tgacgctcct gtccttgccc gtgcagatgt
     4081 tggtattgca atgggtgggc ttggttcgga tgcggccatt gaagcagcag atgtagttct
     4141 gatgacagat gaaccgtcta agctggtgga cgcgattgaa gtagcaaaag cgacaaaaca
     4201 gattgtcatg cagaatatag tgattgctct tgggattaag agtgtgttcc tgattcttgg
     4261 cgctcttggt attgcgggaa tgtgggaagc tgtatttggt gatgtaggcg ttaccataat
     4321 tgctgttttg aacgcaatga gaattttgaa aaaataggaa atgaggtgga aatgtgaaac
     4381 gaaaactgat tctgttagtt gttacgattg tttttcttgt aggttttggt gtcattttac
     4441 attcaccgcc ttctatgatt gatgcagtca caggagcaac accgaagtca aaaaaggcgg
     4501 ctcaagcctc cgcacagttg gaaggctctt atgttctcgg tattaatatg atgtcagatg
     4561 gtctcgacaa cgagaacacc cggaataaat taaaagaatt ggcactggac gattcggaaa
     4621 caaatgaaac agatctcatg aaaacggaca ttagttttcg gttatatgta tctgagacgg
     4681 attatccgct tgtcagttat gctaagaaac tctgtgacag gttgaaacag gccggttttt
     4741 ccgtagatct gaaagagtac agtaacacaa tgatgctatc aagagtggta agtggaaagt
     4801 atgatgtatt cctggcatcg gatgatttta ttgacgttac aacgctaaca cagatggact
     4861 atatgatcat ggacagcgaa gaaatgaggt gagcgggaat ttatgagaaa atggaatacg
     4921 attttgtctg ttttaatgct tctcattttt atgattcatg gaatcatggg aagctttatg
     4981 ctgaacggag ttggaagtag tgcagggaaa cttcttgcat ggattggtgt tggtattctt
     5041 gttgtgcata cggtgattgg tgtcatcctg acagttcaga gtttacagac agcgaagcaa
     5101 tccggaaaaa tgtatctgaa acagaacgcc atattctggg cgagacgagc cagtgggctg
     5161 gcaatactga tcctgctgtt cttccatatt ggcttgtttg gaaaggtgca gaatgggaca
     5221 tatattttgt tcccttttac aacggtaaag atggtaactc agcttttgtt cgtggcggca
     5281 atctttgttc atatttttat caatatccgc ccattgctcg tatcgctggg aatcatcagt
     5341 tataaagaac gaaggggtga tatttatttg attctttcgg tgctccttct gtttatagcg
     5401 ggcgcagtta ttttctatta tattgggtgg caatatctat gagtaagaca attattatta
     5461 taggtgctgg actggcagga ctttcagcgg ctttgcaggc agcggaaaat ggatgcaatg
     5521 taaaactggt ttcctccctt ccgtcagagc gggcacagtc tgttatggcg gagggcggta
     5581 tcaacgcagc tttgaataca aaagatgaaa acgacagtcc cgaagaacat tttacagata
     5641 caataaaggc agcatgtggt ctggcagatc caaatgcagt ttggggaatg acacaggcag
     5701 caccggagct ggtgcactgg ctgctaaaac ttggagttaa atttaacatg agtggctatg
     5761 atgatgtgga tctgcggaat tttggcgggc agaaaaagaa acggactgct tttgcacaga
     5821 gcgataccgg gaagcagatc atgacagcta tgatagacgc tgttcgcagg aaagaagcat
     5881 ctggtatggt agaacggttc agccatcatt ctttcctaac acttcgtctg tgtggcaata
     5941 tttgttgtgg ctgcgtaatc agggatgaat acagtcagga gactgtggaa ttaccggggg
     6001 atgcggttat tgttgccacc ggtggtatgc acggattgtt tggaaataca acgggttcgc
     6061 tgagcaatac aggagaagtc accgcagaat tgttccggct tggtgttcct ctggcaaata
     6121 gcgagatgat ccagtaccat ccgacaactg tgaaatgtgg tggaaaacgc atgctcatca
     6181 gcgaggcggc cagaggggaa ggtggcaggt tgtttgccat gaaagatgga aaacaatggt
     6241 atttcatgga ggaaaaatac ccggagcttg gaaatctgat gccacgagat attaccgcca
     6301 gagagatatg gaaggtcagc catgaatcag aggtatttct tgacatgacg gaaatatcgg
     6361 aggagattat ttcaaataag ctatctggtc tggcagacga ttgtatgacc tatctgcata
     6421 aagatatacg aaaggaaccg gtgtctgttt taccgggaat tcactatttt atgggaggca
     6481 ttctggtgga tgagcagcac agaacgccga ttcagaatct ttacgctgcc ggagaatgct
     6541 gtgcccaata tcatggtgcc aaccgtcttg gtggaaattc tctgttagga gcgttatacg
     6601 gaggacgtgt tgcggcaaaa tcagcacgtg aacaggcaga tgtagtagat ctatcttgtg
     6661 cgacacagat agattttcca ccaacgtctc aaatttcaga aataaagcaa ttaaacaaag
     6721 tgatgcagga tactatgggc gttgtcagaa atgagaatac gttgttaaat gggattcaaa
     6781 cggtacaagc gctgacagga aatcttccat tgcttggcat ggcagttcta aagagtgctc
     6841 ttgcaagaaa agaaagccgt ggtgcacact ggcgggagga ttatccgaag agcaatgacg
     6901 atgattacct taaaacaacg gtagccagat ttgatggaaa gcagatacag atttcctttg
     6961 tacctgttcc agaaaggcgg tgattcactt ggtatataaa ataagaatca ggcggcagga
     7021 gagtcagaaa tcagacagtt attggcagga atttgagttt gacggaagca aaaacagctc
     7081 tgttgccaat gttctaaagg aattgaacag tagaacccct ttgaaagata attcagggaa
     7141 tatagttact cccatcagct gggaatgtag ctgtatggtg cgaaaatgtg gggcttgcgc
     7201 catgctgatt aacgaacgtc cgaggctggc atgctctaca tttctacata cgttaaaagg
     7261 ttctacaatc accttggaac ctttaagcaa atttccgctt gtaagagatt tgatcgttga
     7321 ccggtcaatt ctgtttgaaa atttgaaaaa actgaacctt tggcttgaaa gtgaagctta
     7381 tatgaatcgg tggacacatg aaccgagata ccagtcggca cgctgtctaa tgtgtggctg
     7441 ctgccttgaa gtgtgtccta acttctctgc aaatgggact ttcgcaggcg ctgttgctgc
     7501 agtcaacgca tttcggattc tgaatgaaga acaggaaagc actcatttga atgagatttc
     7561 tgctgaatat aagaagaaat attttgaggg atgcgggaag tcgttatctt gtcatgatat
     7621 ttgtccgatt ggtctgcctg tggaagaact gcttgtaagg tcgaatgcag cggctgtttg
     7681 gggcaaataa aatggatgat aaaagctata atgaatgtat gaagagaatc aaaaacttaa
     7741 gacatggatc acaccggatc ttgcgacgga gtatctcgca ggagccgtgc ttctcggagc
     7801 agctccatgt accgctatgg tatttgtctg gagtacgctg acaaagggaa atccggctta
     7861 tacagtagtt caggtggcat caaatgacat tattatatta tttgcatttg taccgattgt
     7921 gaaatttctg cttggtgttt ctaatgttag tgttccgttt cagacgttat ttatgagtgt
     7981 ggttctattt gtagtaatac cacttgcagc cggaatcata acaaggctgc tggtagtcag
     8041 aaagaaaggt acggaatact ttgagcagac ttttctgcat aaatttgatt ccgcaacaac
     8101 agtgggactt ttgctcacgc tgatactgat ttttatgttt cagggcgagg tggtgctgga
     8161 caatccactg cacattatat tgattgcagt tccgctgatc attcagacat tctttatatt
     8221 ctttctggca tttggagtat gcagaattat cagacttccg tatgatattg cagccccggc
     8281 tggaatgatt ggtgcatcga atttctttga gttagctgtt gcagtcgctg tagctttatt
     8341 tggtacatca agtccagcgg cactggcaac tacagtaggt gtattaacag aagtcccggt
     8401 aatgcttact cttgtgaaga ttgcaaacaa attaaaggag aagttcaagt atgaataaga
     8461 aaaaagttgc ttttatatgc gttcataatt catgcagaag ccagattgca gaagctttgg
     8521 gaaaacatct ggcttcggat gtatttgaaa gttattcggc agggacagaa acgaaactac
     8581 agattaatca ggatgcagtc cggattatga aagaattgta tggaattgat atggaagcag
     8641 aaggacaata tagtaagctg attgatgaga taccagtacc ggatattgca atttcaatgg
     8701 gttgtaatgt gggatgtccg tttatcgaaa gaccgtttga tgataattgg ggacttgaag
     8761 atccaaccgg aaagagtgac gaagagttta agaaggttat tgatgagata aggatgcaaa
     8821 tttttatatt gaaacaacga ttggatgaat ttgaagaaaa ctaaagaagt tgagaaattg
     8881 cagttgatat ttcacatatt ttaggaaatt taataactgt tatatttgat tatcaaattc
     8941 ttcgcaaacc cttgaaaata ctaagtttgt agcaagtgaa ctttccctta ctctttccct
     9001 tgtgttacat tttcccattg cttttcatga accttaatat gggaaaaatt aagggaaaga
     9061 aaatttcata acacaatata acatataaca ataacgacat ggtgaactga ttgaaatgtt
     9121 ttcgatattt aactctgtaa ctgattatca aaagaaaatg gagataagat acgatgagaa
     9181 caatttatgc agaatataat ataaaccacg atagtattga tgtttacaca agtgctggat
     9241 atatgcttcg cattgattgc tgggaagctg aaaaaaattt aaaaaccaca tatggatcag
     9301 aatgtgcgct tacttcattg gctgtggatg agcctttgga atatgcaaga ttatatcttg
     9361 atggcaattt acagatgtgg gtggatacag aagattcatt agaactttat taagcaagaa
     9421 gtgagatagt gttgtaggga gtttcctgta gttaaagata ccacacccga tatgatgaac
     9481 ccacgcttat acactaccag ctatgataaa agaaaggaca gcaatttgac actgctgtcc
     9541 tttcttttat aaaattgcag tacacagaaa aaagctgtaa aatgaaaaat atatttgtcc
     9601 ttgtaacaat tctcggacat ttgcctgtta tactatctgc aaaaagaaaa ggaagtgata
     9661 atatgaagca tattttaatt gtcgaagatg ataatctttt gaataaaacg cttacttata
     9721 atttggaatt ggacggttac acaataactt ctgttctgaa tgcaaggaca gccgctgaat
     9781 cattaaaaac aaacattttt gatttggtat tgctggatat aaatttacca gacggaaatg
     9841 gttatgacct atgccgtctt atcaagccag agcatcctga tacagtagtt atatttctaa
     9901 ctgccaacga tcaggaaagc aatcagatac ggggatatga agctggtgca gtggattata
     9961 tcacgaaacc tttttcgatt agtgctttgc agcgaaaaat caaagccatg ttcgctatgt
    10021 tggagcatca caaaccagct aaggatattt acgaggatgg tagcttgttt ctggattttt
    10081 cggaacaatt tgcaagtttg aacgggaaac cattagcact ttctgcgatg gaatataaaa
    10141 tgttgaacct atttcttaaa aatccgaagc aggtacttac tcgccaacaa tttttagaaa
    10201 aactgtggga tgttgatgaa aaatatgtag atgaacatac ccttactact tctatcagcc
    10261 gtattcgcag taagattgaa gcggatggcg acacatatat caaaacggtt tatggtatgg
    10321 ggtatcaatg gacaggaggc gaaaagaaat gaatctgaat aacctttctg ctaagaaaat
    10381 ttgtagactg gttagtgctg gcatggtttt ctctatgctg gtaattaccg gtattttcgg
    10441 cggtataatg caggatatac gaatttttat agtgggtgga acattgacac tctgtgcgtt
    10501 tttctggatt tggctattgg tgctgatttt tggaaaacgc ctttctcatt ttacttctaa
    10561 tttgtgccgg acgctggaca acatgattga tggaaacgag gaattacaaa agtcaaatga
    10621 tagtgaaact ctttttgccc gtatcaacca ccgcttaatt cggttgtatg agattatgca
    10681 gaaaaaccgg cacaaggtag acatggaacg acaggagctt caaatgctga tttctgatat
    10741 ttcacatcaa gttaaaacgc ctgtcagcaa tttgcaaatg gtaacggaca cacttttaac
    10801 aaagcctgtt tcagaagaag aacggatgga ctttttacaa ggcatacgta gtcagactga
    10861 taaactggat tttctgttcc aagcactggt taaaacgtcc cggttggaaa ccggagcaat
    10921 acgattagaa aagaaagaca gcagcttatt ccatacgctt gcacaagcca tgagcagtat
    10981 tgtatatgtc gcagagaaaa aagaaattgc tgtatccgtg gattgcccgg aaaatttgat
    11041 aatctcccat gacagcaagt ggacaagcga agcccttttc aatctgctgg acaatgcagt
    11101 aaaatacact ccgtcaggtg gaaagatttc tgtatcagtg gttcagtggg aaatgtacgt
    11161 agaggtcaaa gtgaccgaca ccggcaaggg catttcagaa agcaatcagg ctgccatctt
    11221 ccggcgcttc tatcgtgagg aagaagtaca cgatcaacag ggtgtaggaa taggtttgta
    11281 tttggctcgt gagattgtaa caaggcaagg gggctatatc aaggtcgttt cagagctggg
    11341 gcaaggctca gaattttcta ttatgcttcc tgtaaggtaa gatataacca ctttttttga
    11401 aatgtccgag cgttgtaaca tttcaccctg attttcgata aaaatttttt ctatctcgga
    11461 catttgtgta acatttgtgg tttacaatgg ctttatcaac agatagaaag ccttgaaagg
    11521 agcatttgaa tatgagcatt ttacaaacaa tcgacttaaa gaagtattac ggcacagaac
    11581 caaatattac tcgtgccctt aatggtgtaa attttactgt ggaacaggga gaatttgttg
    11641 ccgtagttgg aacttccggc agcggtaagt ctacattgct tcacatgatg ggaggacttg
    11701 atacccccac ttccggcagc gtgattgtac ggggagaaga actcgcaaaa aagaatgatg
    11761 atgaattgac aattttccgc cgtcgtaaca tcggatttat cttccaaaat tataatctgg
    11821 ttccgatttt gaatgtatat gaaaatatcg tcctgcctgt ggaactggat ggcgatacag
    11881 tagaccagaa atttatggac gaagttgtgt atatgttggc tttagaagat aaactggaaa
    11941 atatgccgaa caatctttca ggcggtcaac agcaacgtgt agcgattgca cgagctttaa
    12001 ttacgaagcc tgcgattatc cttgctgatg aaccgaccgg aaatcttgat agcaagacca
    12061 gtgcagatgt gttagggctt ttgaagcata ccagcggaga atttaatcag accattgtaa
    12121 tgattactca caacaacgag atcgctcaac tcgcagaccg cattgtacgg attgaagatg
    12181 gtaaaattgt tggctaaagg aggtgggaat tatgaattat ccttttgaaa atgataccag
    12241 tgcagtaatt aaaaaattag cacgaaaaag tgtgcgtttt gataagaaga aaaacttatt
    12301 ttgcctttcg gcaattattg tagccgttgc tatgataatg atgtcgttgc tcacagtgca
    12361 aaatatcatt tatcaaaatc agaaagaaat cgaaggatta catcaaggga ttttctttga
    12421 cattacgcag gacagtaaag aaaagttgtt agcaaacgaa gaagtaaaaa gtgtaggact
    12481 ttcctgtaat atcaaaacag tgaaagaaaa ttctaaagaa ctgtctctga tttattatga
    12541 tgatgacatg cttagtttga ttcctgcctt tgacggaaaa tatccagaga aagcaagtga
    12601 aattgctgtt acagatgcct tttttgccag tgaaaataag tctccggaaa tcaacgccat
    12661 agttcagttg aatctggatg gtactttgaa gaattatact attgttggta tttatcatga
    12721 taaaacttct accgcttatc ctgtttttgt ttcacttgaa aaatgccggg aattacgtgg
    12781 aaataacctg cttaatggat atgtttggct tgaaaatgca gataccctta caaaagacga
    12841 agcaacagaa atattatctc aaatttcaga ggagactgga ctgaataatt ggacagtcag
    12901 cagttactat gattatgtaa atacaacttt gtccttcagt aattatgcgg tatatggtgt
    12961 agttgctgcc attttgtttt tagctgccgc acttgtaatt tacagcattt tctatatttc
    13021 ggttggacaa aaagttgctg agttcggaca gcttcggaca ataggggcaa gtaaaaagca
    13081 aatttataaa atagttctta aacagggtta tatgcttgca gttccgggga ttttaattgg
    13141 tagtatcatg ggaacgatca tcagctattg tctgcaatca aaaggctggt cagtatttgc
    13201 atttattgtt tctctatgtg gcgcatgcct ttttggaata ctgcttgttt atattagtgt
    13261 tcgtaaacca gcaaaaattg cagcgaatac ttctccaatt tccgccctga aaaatccagt
    13321 gggaattgta aattaccgca ctcacaaaag acatcgtatt acgcctgtat atttagcgaa
    13381 aatcagcttt tccagaaaca gaaaaaaatc tctattgacc attttatcat tgggactgtg
    13441 cggagttata tttttccttg cagcaagtta tcagagttct tttaatgccg agagtatggc
    13501 tcgttattgg gatatgaagt acggagattt caaaatcagc attgatttag aaaacgaaag
    13561 tgaaaatttg gatgctctct tgcagaaaga atatttttct gattatgtaa agcgtgttgg
    13621 agatatagag ggagttagca atatatttac ttatgctacc gtaccagttg atttctcaac
    13681 agacaatgat atttcagata gcaccttgat gctcggctat aatgaaaagg atttggcgtc
    13741 gctaaatgca gcggttttgt ctggaaatat tactgatgat acagaattag ttgtaagtga
    13801 tcccgaacgt atttatgatg tttaccattg gaaacctcaa attggggata ctgtgacctt
    13861 taatttcaaa aatcatagtg gtaaaacaat aacaaaagca ttcaaaattg gtgcaatcac
    13921 ttccagcaat gatggaatgg gtggctatat tttcagaatg ccggaaaata tgctcaaaga
    13981 acttgcaggt tatgactgta catacgcaat cgaaatacaa gcagaagctg aatatcagga
    14041 gataatcgag caagaactca aattactcgt ttctgacaat agggatgttc gcttacaaac
    14101 ccttcaagat tttattgtag aacaccaatc agacaatcgt gcaggtttta cattagctta
    14161 tgcgattgca gccatcttgt ggatatttgc ggtcatcaat caaatcaatc ttactgtgac
    14221 aaatctttta tcacagaaac aggaaatggg cacactaaaa tctattggta tgacaaataa
    14281 gcagttgaag caagcattta tgatggaagg tctttttact actttgattg cattgcttat
    14341 aactgctgtt gttggaatcc ccggcggata tgcaatcggt atatttttga aaaatgcagg
    14401 catgtctacg ggatttgtat ttccggttgt tgcttttact ctttttgctg ttgctatgtt
    14461 tatgcttgaa agtttgatga caatattgct tattcattca tggaagaagc aatctgttat
    14521 tgcaataatg cgaaattgat gatagaaagc ttttcatatc tcggtcagct ccacaattac
    14581 attactctgc tgatacagcc agtccgtaaa ttctttcggg ctggctgttc ctgtttttac
    14641 agcctttttt ctctgtaata cttcttttca tacagtaaat tttcactagg ctggtatgga
    14701 gtaattttac tgtctataca gtaagttgaa aatactaata tggtcttttt tctaaccaaa
    14761 ctttaagata acatctaatt ccaacatatg cgccctgcga aagtacgaaa agcaatagaa
    14821 gatttactga cagtactttt ttgattgatt ctccaaaata aatgacaata gcaacacttg
    14881 tcagtatcat tagtagagta ataacatccc aacagttttt cttatataat tctataacct
    14941 ttatttctat cagtatcgcc agcatccctg ttcctgccat acatattcct acaatcaata
    15001 ttagcaataa ccaatatacc attccggcta taaaagcatt tggaattttt gtactaatct
    15061 gtgccgcaga atgcccggca tcaatcgtcc atccgacaaa gatttgtatg aatgatgcta
    15121 aatcattgaa gaatgattta caatcgacaa ggaacatatc tgactgtact gcctgaaaaa
    15181 gagtggttgt caacgaatac catgcaagaa ggaacaaggt tgtttggaac attaccgttt
    15241 ttgctttata ctgtcctgca agtcgctctt tttgtgtttc gtattttgct tttgcattct
    15301 gataggctgt ccggttacag gcttcacatt tttcatagag taccggcttt tctaccggta
    15361 tttctacgat tttctgatgt gtccgggcat aatcccgttc ctgtgttaaa tagcatattt
    15421 tatcttgaca ttcctctatc atgacgtttg cgcttcgcaa cttctctttc tcgatccgca
    15481 atgctctgtc tgccagcttc aagtcgttct ttaatgcttg aatattcccg gctctgttct
    15541 ctttgtttaa tttctcgttc aaggtcagag attcgctgag ctgcgtcttc agttccacga
    15601 taagctgttc tttctgttct agttcttctt gtatctcctc ggtcaagagc agaagttctt
    15661 ccaactgttc ggcgttcttt gattctctgg attcgttcat ctatatcacg tcctttctct
    15721 atctgctgtt ccagttcagc aattcggtgt tctgtttcag taataaactg ttttcgctgt
    15781 tcagcttctg tgccaatttc tgccattgct gattttcgtt ttccaaaagc tctatcttcg
    15841 ttttctgttc ttccatcttg gaaagcagtt cctcggtatt tggcaaaatg ttgagcagct
    15901 cggataactc gttgtttaat ttttgtaatt tctgattctg tttttgcata agagagagtt
    15961 gagtgtcccg gttctgcatt tccagaatca tttctgccat taggttctgc tgttcttcga
    16021 tttgaccaat catggattcc attaagggta taatttcccg gctttcttct aatgtcattt
    16081 aatcgctcct tccataatga taatgcaccc gatactttcc caaaggtgtt tagtatcttt
    16141 tgcaataacg tgttttgttg ttttatgatt tgattttccg ctactttcca cgagcctttt
    16201 atttcctgcc cggcaaaaaa cttttgttca atctttcttg cgtcagctcc ttcatggatg
    16261 gtaggaatct ggagttttcc ctgcttttca taagaacgat gatcaacttg attatgcaaa
    16321 ggcagatgtt cattacatac ctttgcccat tcactccgcc acagttcaca attttttgga
    16381 ttgttccatc cagtagcatc ggtcagcacc cgtttccatt gcaggcggtt tcttgctcca
    16441 atcttctgaa ttccgttttc gtctaataca gggatacgga ttccatgacg gtcagggttt
    16501 ttcttatcct gccaccagtt cggatgggat tcatcaatca cgatatttcc gtttttatct
    16561 ctgacaaaat cccaatcctt gacttctttc tttccccaag aatgatccgg gttaaaagga
    16621 cgcatagtta gaagcagatg gacatggggg ttgccatccc ctttgtcgtg gatactccaa
    16681 tcagcgcaca ttcctctatc tacaaaagtt ttttggatat agtcggttgt atattgaatt
    16741 tgttcctgtc tgctccattc tttggggagg gcaaattcaa atgacctgcc aagtt
//
