LOCUS       c00039_gnlPro..        15456 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|DCPIMBAF_39.
ACCESSION   c00039_gnlPro..
VERSION     c00039_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-06 06:13:07
            Original ID  :: gnl|Prokka|DCPIMBAF_39
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 15456
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..15456
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[2514:12452]"
                     /cutoff="10000"
                     /detection_rule="(Oxidored_q4 and Oxidored_q6 and
                     Complex1_30kDa and Complex1_49kDa and NADHdh and
                     Oxidored_q3 and Oxidored_q2 and minimum(4, [Fe-2S_thioredx,
                     Fer2_4, Fer4_7, Molybdop_Fe4S4, Molydop_binding,
                     NADH-G_4Fe-4S_3, NADH_4Fe-4S, Proton_antipo_M,
                     Proton_antipo_N, SLBB]))"
                     /neighbourhood="10000"
                     /product="NADH_dehydrogenase_I"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      2515..12452
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(Oxidored_q4 and Oxidored_q6 and
                     Complex1_30kDa and Complex1_49kDa and NADHdh and
                     Oxidored_q3 and Oxidored_q2 and minimum(4, [Fe-2S_thioredx,
                     Fer2_4, Fer4_7, Molybdop_Fe4S4, Molydop_binding,
                     NADH-G_4Fe-4S_3, NADH_4Fe-4S, Proton_antipo_M,
                     Proton_antipo_N, SLBB]))"
                     /neighbourhood="10000"
                     /product="NADH_dehydrogenase_I"
                     /protocluster_number="1"
     cand_cluster    1..15456
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(Oxidored_q4 and Oxidored_q6 and
                     Complex1_30kDa and Complex1_49kDa and NADHdh and
                     Oxidored_q3 and Oxidored_q2 and minimum(4, [Fe-2S_thioredx,
                     Fer2_4, Fer4_7, Molybdop_Fe4S4, Molydop_binding,
                     NADH-G_4Fe-4S_3, NADH_4Fe-4S, Proton_antipo_M,
                     Proton_antipo_N, SLBB]))"
                     /kind="single"
                     /product="NADH_dehydrogenase_I"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..15456
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="NADH_dehydrogenase_I"
                     /region_number="1"
                     /rules="(Oxidored_q4 and Oxidored_q6 and Complex1_30kDa and
                     Complex1_49kDa and NADHdh and Oxidored_q3 and Oxidored_q2
                     and minimum(4, [Fe-2S_thioredx, Fer2_4, Fer4_7,
                     Molybdop_Fe4S4, Molydop_binding, NADH-G_4Fe-4S_3,
                     NADH_4Fe-4S, Proton_antipo_M, Proton_antipo_N, SLBB]))"
                     /tool="gutsmash"
     CDS             complement(154..1758)
                     /locus_tag="ctg39_1"
                     /transl_table=11
                     /translation="MKRTLWFIFFLLNSLFYLYADSENDSLLKVLDKVISERLIYTQKK
                     EATIKELKKKKVGLNSLEDIYNLNKEIIHQYETFVCDSAEQYIHENIDIAKTIGNKEYL
                     LEEQLRLAFVYSLSGLFIQANDIFKSIKCADLPDHLKALYCWNRIRYYENLIKYTDDVR
                     FSNEYISEKEAYRDTVMSILFDQSDEYRKEKAVKLQDKGSTKEALLILTEIYDKQEPAS
                     HGYAMMAMGLARAYRLIGNYALEEKFLMLAAMTDTKLAVKENEALLTLAVNLYHKGDID
                     RAYNYIKVALDDAIFYNSRFKNTVIARIHPIIENTYLIRLEKQKQNLRFYIFLTSLFVV
                     ALAITLYFTYKQTKIVSRAKRHLKAMNEELVGLNKNLDEANLIKEKYVGYFMNQCAVYI
                     NKLDEYRKNVNRKIKTGQIDDLYKSSSRPFEKELEELYHNFDKAFLKLYPNFVEKFNSL
                     LKPEERYKLEKDQLNTELRIFALIRLGITDVGQIAVFLHYSVQTIYNYKSKVKRMSTLD
                     SNIFEEEVKMLGSLSQK"
     CDS             2019..2396
                     /locus_tag="ctg39_2"
                     /transl_table=11
                     /translation="MKQSLKFGLLLVLALLIHCATNGAMEDMCKVSSPTYRQEKCYVSQ
                     DRPIQDALERLYNLYTTQTCDMSHTDVAHVPTDKSMFLLIAYFCDHYKHQSPLYPVSSH
                     SPTYYYDPISYYIYGLRKIVI"
     CDS             2515..2865
                     /gene_functions="biosynthetic (rule-based-clusters)
                     NADH_dehydrogenase_I: Oxidored_q4"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg39_3"
                     /sec_met_domain="Oxidored_q4 (E-value: 2.7e-38, bitscore:
                     120.0, seeds: 391, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNFTFLVVVLLTALAFVGVVIALSRAISPRSYNLQKFEAYECGIP
                     TRGKSWMQFRVGYYLFAILFLMFDVETAFLFPWAVVMRDMGPQGLISVLFFFIILVLGL
                     AYAWRKGALEWK"
     CDS             2856..3458
                     /gene_functions="biosynthetic (rule-based-clusters)
                     NADH_dehydrogenase_I: Oxidored_q6"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg39_4"
                     /sec_met_domain="Oxidored_q6 (E-value: 1.1e-26, bitscore:
                     83.0, seeds: 164, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MEITKKPKIKSIPYDEFIDNESLEKLVKELNAGGANVALGVLDDF
                     INWGRSNSLWPLTFATSCCGIEFMALGAARYDMARFGFEVARASPRQADMIMVCGTITN
                     KMAPVLKRLYDQMPDPKYVVAVGGCAVSGGPFKKSYHVVNGVDKILPVDVYIPGCPPRP
                     EAFYYGMMQLQRKVKIEKFFGGVNRKEKKPDYLKNEE"
     CDS             3486..5078
                     /gene_functions="biosynthetic (rule-based-clusters)
                     NADH_dehydrogenase_I: Complex1_49kDa"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     NADH_dehydrogenase_I: Complex1_30kDa"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg39_5"
                     /sec_met_domain="Complex1_30kDa (E-value: 1.1e-36,
                     bitscore: 115.9, seeds: 586, tool: rule-based-clusters)"
                     /sec_met_domain="Complex1_49kDa (E-value: 8.7e-66,
                     bitscore: 211.5, seeds: 265, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MQEIQFIAPAALHDEMLRLRNEKQMDFLESLTGMDWGVADEKDAP
                     EKLRGLGVVYHLESTITGERIALKTATTNRELPEIPSVSDIWKIADFYEREVFDFYGIT
                     FVGHPDMRRLYLRNDWIGYPMRKDNDPEKDNPLCMTNEETFDTTQEIELNPDGTIKNKE
                     TKLFGEEEYVVNIGPQHPATHGVMRFRVSLEGEIIRKIDANCGYIHRGIEKMNESLTYP
                     QTLALTDRLDYLGAHQNRHALCMCIEKAMGIEVSERVQYIRTIMDELQRIDSHLLFYSC
                     LAMDLGALTAFFYGFRDREKILDIFEETCGGRLIMNYNTIGGVQADLHPNFVKRVKEFI
                     PYMRGIIHEYHDIFTGNIIAQSRMKGVGVLSREDAISFGCTGGTGRASGWACDVRKRMP
                     YGVYDKVDFKEIVYTEGDCFARYLVRMDEIMESLNIIEQLIDNIPEGPYQEKMKPIIRV
                     PEGSYYAAVEGSRGEFGVFLESQGDKTPYRLHYRATGLPLVAAIDTICRGTKIADLIAI
                     GGTIDYVVPDIDR"
     CDS             5099..6175
                     /gene_functions="biosynthetic (rule-based-clusters)
                     NADH_dehydrogenase_I: NADHdh"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg39_6"
                     /sec_met_domain="NADHdh (E-value: 3.7e-123, bitscore:
                     400.3, seeds: 435, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MFDFSIVTNWIHELLLSIMPEGLAIFIECVAVGVCLVALYAILAI
                     ILIYMERKVCGFFQCRLGPNRVGKWGSIQVVCDVLKMLTKEIFMPKGADHFLYNLAPFM
                     VIIASFLTFACIPFNKGAAILDFNVGVFFLLAASSIGVVGILLAGWGSNNKFSLIGAMR
                     SGAQIISYELSVGMSIMTMVVLTGTMQFSEIVEGQADGWFIFKGHIPAVIAFIIYLIAG
                     NAECNRGPFDLPEAESELTAGYHTEYSGMGFGFFYLAEYLNLFIVASVAATIFLGGWMP
                     LHIVGLDGFNTVMDYIPGFIWFFAKAFFVVFLLMWIKWTFPRLRIDQILNLEWKYLVPI
                     SMVNLLLMACCVAFGFHF"
     CDS             6188..6676
                     /gene_functions="biosynthetic (rule-based-clusters)
                     NADH_dehydrogenase_I: Fer4_7"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_4"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1020:4Fe-4S binding domain (Score: 31.7; E-value:
                     2.8e-10)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg39_7"
                     /sec_met_domain="Fer4_7 (E-value: 4.3e-13, bitscore: 39.6,
                     seeds: 208, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_4 (E-value: 9.8e-06, bitscore: 15.9,
                     seeds: 79, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MEYKDKKYTYLGGLVHGISTLATGMKTSIKVYFRKKVTEQYPENR
                     KELKMFDRFRGTLNMPHNENNEHRCVACGLCQMACPNDTIKVTSETVETEDGKKKKILA
                     TYEYDLGACIFCQLCVNACPHDAITFDQNFEHAVFDRTKLVLKLNHDGSKVIEKKKEV"
     CDS             6679..7191
                     /gene_functions="biosynthetic (rule-based-clusters)
                     NADH_dehydrogenase_I: Oxidored_q3"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg39_8"
                     /sec_met_domain="Oxidored_q3 (E-value: 4.7e-38, bitscore:
                     119.9, seeds: 708, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MGSTLETVVFYFLAAFIIAMSIMTVTTQRIVRSATYLLFVLFGTA
                     GIYFLLGYTFLGSVQIMVYAGGIVVLYVFSILLTSGEGDRAEKAKRSKLLAGLITMIAG
                     LAIILTITLKHNFMQTANLAPHEINIHAIGNALLSSDKYGYILPFEAVSILLLACIIGG
                     IIIARKR"
     CDS             7224..7532
                     /gene_functions="biosynthetic (rule-based-clusters)
                     NADH_dehydrogenase_I: Oxidored_q2"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg39_9"
                     /sec_met_domain="Oxidored_q2 (E-value: 1.9e-22, bitscore:
                     68.8, seeds: 63, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIHMEYYLVVSTIMMFAGIYGFFTRRNTLAILISVELMLNATDIN
                     FAVFNRFLFPEGMEGYFFALFSIAISAAETAVAIAIMINIYRNLRSIQVRNLDELKW"
     CDS             7588..9477
                     /gene_functions="biosynthetic (rule-based-clusters)
                     NADH_dehydrogenase_I: Proton_antipo_N"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     NADH_dehydrogenase_I: Proton_antipo_M"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg39_10"
                     /sec_met_domain="Proton_antipo_N (E-value: 2e-25, bitscore:
                     78.5, seeds: 433, tool: rule-based-clusters)"
                     /sec_met_domain="Proton_antipo_M (E-value: 1.5e-87,
                     bitscore: 283.2, seeds: 14, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MELTILILLLPFFSFLILGIGGKWMSHRTAGTIGTLILGAVAVLS
                     YVTAIQYFSAPRLEDGTFATLIPYNFTWLPFTETLHFDLGILLDPISVMMLIVISTVSL
                     MVHIYSFGYMKGEVGFQRYYAFLSLFTMSMLGLVVATNIFQMYLFWELVGVSSYLLIGF
                     YYTKPAAIAASKKAFIVTRFADLGFLIGILIYGYYGGTFGFTPDTVSLISGGASMLPLA
                     LGLMFVGGAGKSAMFPLHIWLPDAMEGPTPVSALIHAATMVVAGVYLVARMFPLFIAYA
                     PNTLHMVAWVGAFTAFYAASVACVQSDIKRVLAFSTISQIGFMMVALGVCTSMDPHEGG
                     LGYMASMFHLFTHAMFKALLFLGAGSIIHAVHSNEMSAMGGLRKYMPITHWTFLIACLA
                     IAGIPPFSGFFSKDEILAACFQYSPVMGWVMTVIAAMTAFYMFRLYYGIFWGKENKELH
                     AHHTPHESPLAMTFPLMFLAVVTCGAGFIPFGHFISSNGESYSIHLDPSVAITSVVIAI
                     ISIAIATWMYKNAKQPVADSLEKQFKGLHKAAYNRFYIDDIYQFITHKIIFRCISTPIA
                     WFDRHVVDGFFDFLAWATNTTSDEIRGLQSGQVQQYAYVFLCGALALILLLIL"
     CDS             9491..10975
                     /gene_functions="biosynthetic (rule-based-clusters)
                     NADH_dehydrogenase_I: Proton_antipo_M"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg39_11"
                     /sec_met_domain="Proton_antipo_M (E-value: 1.1e-68,
                     bitscore: 221.3, seeds: 14, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNFLSIFVLIPLLMLAGLWAARGIKAIRGVMVTGASALLIASVVL
                     TFLYLGERSAGNTAEMLFRADTLWYAPLHISYSVGVDGISVAMLLLSAVIVFTGTFASW
                     RLQPLTKEYFLWFTLLSMGVFGFFISVDLFTMFMFYEIALIPMYLLIGVWGSGRKEYAA
                     MKLTLMLMGGSAFLLIGILGIYFGSGATTMNLLEIAQLHNIPFAQQCIWFPLTFLGFGV
                     LGALFPFHTWSPDGHASAPTAVSMLHAGVLMKLGGYGCFRIAMYLMPEAANELSWIFLI
                     LTGISVVYGAFSACVQTDLKYINAYSSVSHCGLVLFAILMLNQTAATGAILQMLSHGLM
                     TALFFALIGMIYGRTHTRDVRELAGLMKVMPFLSVCYVIAGLANLGLPGLSGFIAEMTI
                     FVGSFQNNNQFHRVLTIIACSSIVITAVYILRLVGKILYGTCTNKHHLELTDATWDERV
                     AVICLIVCVAGLGMAPFWVSHMIGESVLPVVSQLIP"
     CDS             11013..12452
                     /gene_functions="biosynthetic (rule-based-clusters)
                     NADH_dehydrogenase_I: Proton_antipo_M"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg39_12"
                     /sec_met_domain="Proton_antipo_M (E-value: 2.1e-73,
                     bitscore: 236.8, seeds: 14, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDYSQFLYMREELSLIAVLLLLFLADLFMSPDAHKNGGKARLNTM
                     LPVILMAIHTAINLIPGTAADAFGGMYHYVPMHTVVKSILNVGTLIVFLMAHEWMKRED
                     TSFKQGEFYVLTLSTLFGMYLMISAGHFLMFFIGLETASIPMAALIAFDKYRHNSAEAG
                     AKYILTALFSSALLLFGLSMIYGSAGTLYFDDLPAHIDGNPLQIMAFVFFFTGMAFKLS
                     LVPFHLWTADVYEGAPSAVTAYLSVISKGSAAFVLLAVLIKVFAPMINDWQEVLYWVTI
                     ASITIANIFAVRQQNLKRLMAFSSISQAGYIMLGVIGGTAQGMTALVYYVLVYAAANLG
                     VFAVITIVALRSQKFTLEDYAGLYKTNPKIALLMTLSLFSLAGIPPFAGFFSKFFIFMA
                     AFDAGFHLLVFIALVNTVISLYYYLLIVKAMYITPSDNPIPTFRSDRCTKWGLALCTLG
                     IIGLGIASIVYQSIDKLSFGI"
     CDS             complement(12593..15403)
                     /locus_tag="ctg39_13"
                     /transl_table=11
                     /translation="MQTDNERYRKMASLAQIGWWEVDLTAGYYLCSDYLSDLLGLDGDT
                     ISTSDFLNLIREDYRKQIAQEFRANSSIHKDFYEQTFPIHSKYGEVWLHTRLAFREKGT
                     GVDGGDKSFGIIQRVEAPKEEDQRDALRRVNDLLCRQNFVSQSLLRFLRDEAVESCIAD
                     ILRDILNLYNGKGRVYIFEYDEIYAHHSCIYEVVSEGVSAEIDNLQDMPASESKWWSEQ
                     ILSGKPIILNTLEQLLEEAPDEYQILVVQGIKSLMVTPLMTGDRVWGYMGIDLVETYHD
                     WSNEDFQWFSSLGNIINICIELRKTKDKVIREQTFLNNLFHFMPMGYIRMSIIRDENNK
                     PCDYRVTDANEVSSTFFGLPLESYIGSLASEKHPDYLQKLNFLEEILDSNSYREKDEYF
                     PRTERYTHWVIYSPGKDEIVGLFLDSTGSVQANRALDRSEKLFQNIFANIPAGVEIYDK
                     DGYLIDLNNKDLEIFGVVNKSDVIGVNFFDNPNVPQNIRDRVRNEDLVDFRLNYSFEQA
                     EGYYETNRSNAIELYSKVSKLYDNEGNFSGYILISIDNTERIDAMNRIRDFENFFLMIS
                     DYAKVGYAKLNLLNRKGYAIKQWYKNLGEEEDTLLDEVVGVYTHMHPEDRKRFLDFYDE
                     VRDGKRRHFQGEMRIRRPGTKNEWNWVSSNVMVTNYKPEENEIEIIGINYDITELKETE
                     AELIQARDKAEMMDRLKSAFLANMSHEIRTPLNAIVGFSDLLVETEELSERQEYIKIVR
                     ENNDLLLQLISDILDLSKIEAGTFEFTNGDVDVNLLCEDIVRSMGMKAKEEVELVLDNH
                     LPVCHVISDRNRIHQVISNFVNNAMKFTSEGSIHVGYKLKDGELEFYVEDTGIGIEKEQ
                     LPHIFERFVKLNSFVHGTGLGLSICQSIVEQLGGRIGVDSEKGKGSRFWFTIPGVIVTE
                     EVGCAR"
ORIGIN
        1 tatagcagaa ctgtaaaata taaaagaggt tgtgccaacg ttttgacaca acctcgggaa
       61 agtaaacgtt ttacagatca attattatat atacatttaa taatcaacag tttataacaa
      121 gaccattttt tagttttggt aaaccggata gaatcatttt tgagacaaag aaccaagcat
      181 ttttacctcc tcctcaaaga tattactatc aagagtggac attctcttca ctttactctt
      241 ataattatag attgtctgca cagaataatg caaaaataca gcaatctgtc caacatcggt
      301 aattcctaat cgtatcaatg caaatatgcg taattctgta ttcagttggt ccttttccag
      361 tttataacgc tcttccggtt tcaacaaaga attgaacttt tccacaaagt taggatacaa
      421 tttaaggaac gctttatcaa agttatgata tagttcttca agttcctttt caaaaggtcg
      481 ggaggatgac ttatataaat catcaatctg tccggtcttg attttcctgt tcacattctt
      541 cctgtactca tcgagtttat taatataaac agcacattga ttcataaaat accccacata
      601 tttttcctta atcagattag cttcgtcgag attcttattc agtccgacca gttcctcatt
      661 catagcttta agatgccgtt tagcccggga tacaattttt gtttgtttat atgtaaaata
      721 cagggtgata gcaagagcta ccacaaacaa gctagtcaga aatatataga aacggaggtt
      781 ctgcttttgt ttttccaacc ggatcaagta tgtattttca ataatcggat ggatacgagc
      841 aattaccgta ttcttaaaac gggaattata aaagatggca tcatccaacg ctacttttat
      901 ataattataa gccctgtcta tatctccttt atgatacaaa ttaactgcca atgtcaataa
      961 tgcctcattc tctttgacag ctagttttgt atctgtcata gcagccagca ttagaaactt
     1021 ttcttccagt gcataattcc caatcaaccg ataagccctg gcaagtccca tagccatcat
     1081 agcatagcca tgggatgccg gctcttgttt atcatatatc tctgtcaaaa tcagaagagc
     1141 ctctttggta cttcccttat cttgaagctt cacagctttt tcttttctat attcatccga
     1201 ttggtcaaat aagatgctca tcacggtatc ccgataagcc tctttttccg atatatactc
     1261 gtttgaaaaa cgtacatcgt ccgtgtattt aatgagattt tcataataac gtatacgatt
     1321 ccagcaatac aaagctttca aatgatcggg taaatccgca cattttatcg acttaaaaat
     1381 atcatttgct tgaataaaca aaccggataa agaatagaca aaagccaacc ggagctgctc
     1441 ttccaaaaga tattctttat taccgattgt ttttgctata tcaatattct catgaatgta
     1501 ttgttctgcc gagtcacaga caaaggtttc atattgatgg ataatctctt tatttaaatt
     1561 gtatatatcc tccaacgaat taaggccaac cttctttttc tttaattctt ttatggtagc
     1621 ttcttttttc tgggtatata tcaaacgttc agaaatcact ttgtctaaca ccttcaacaa
     1681 agaatcattc tcactatctg catagaggta aaacaaggag tttagaagga aaaatataaa
     1741 ccaaagtgtg cgtttcataa tcatgtattc tttcttaatc tgcaaaaaaa tgtattttct
     1801 ttgtgttatt cgccaaaaag agcgtaaatc attcttttta ttgcatcttt taacaaatga
     1861 agatggagaa attaccccat tctaaatgat atttgtgaaa ccatgctgac taaaaaatga
     1921 atctaaaaga tatggagtta aaaaaagctt ttttgccata cggactttgc aaaaagtata
     1981 aatattagtt ctatatttgc agccgttaaa ggagaaagat gaaacaaagc ttaaaattcg
     2041 gactactttt agtgttggct ttgctcatcc attgtgcaac taatggagca atggaagata
     2101 tgtgcaaagt ttcctccccg acttatcggc aggagaaatg ctatgtatca caagatcgtc
     2161 cgattcagga tgctttagaa cgtctttata atctttatac gactcaaacc tgtgacatga
     2221 gtcatacaga cgtcgcacat gttccgacag ataaaagcat gtttttgtta atcgcttatt
     2281 tctgtgacca ttacaaacat caaagtccgc tttaccctgt ctcatcccat tctcctacat
     2341 attattacga tcctatctcc tattatatat atgggttgag aaagattgtc atttagccta
     2401 cagtacagta gactcttttg ctcgtcattt attacagttg gttttattct ccatagggcg
     2461 aatagactaa ttgcttattt ctatataata ttcaatctaa acagctattg aattatgaat
     2521 tttacatttt tagttgttgt tttactgaca gcgcttgctt ttgtcggtgt agtaatagcc
     2581 ctctcgcgtg ctatctctcc ccgttcatac aacctgcaaa agtttgaggc ttatgaatgt
     2641 ggtataccga cacgtggtaa atcatggatg cagttccgtg taggctacta cttgtttgcc
     2701 atcctattcc ttatgttcga tgtcgaaaca gcttttctgt ttccgtgggc ggtagttatg
     2761 cgtgacatgg gaccacaggg acttattagt gttctctttt tctttatcat tttagttctg
     2821 ggtcttgctt atgcctggag gaaaggagct ttggaatgga aataaccaaa aagccaaaaa
     2881 taaaatctat tccgtatgat gagtttatcg acaatgaatc attggaaaag ttggtcaaag
     2941 aacttaatgc aggaggagcc aatgttgccc tcggagtact tgacgacttt atcaactggg
     3001 ggcgcagcaa ttcactgtgg ccgcttacct ttgcaaccag ttgttgtggt atcgaattta
     3061 tggcactggg tgccgcgcgt tatgacatgg cccgctttgg gtttgaagta gcacgtgcca
     3121 gcccgcgtca ggctgatatg attatggtat gcggaacaat caccaataaa atggctccgg
     3181 tactgaaacg actttacgac cagatgcccg atccgaagta tgtggttgcc gtaggcggat
     3241 gcgctgtcag cggaggtcct ttcaagaagt cctatcacgt agtgaacgga gtggacaaga
     3301 ttcttccggt agatgtatat attcccggat gcccgccacg tcctgaagca ttctattatg
     3361 gcatgatgca attgcaacgc aaagtgaaaa tagaaaagtt ctttggtgga gtaaacagaa
     3421 aagagaagaa accggattat ttaaaaaatg aagaatgatt ctacattctg taatttaaag
     3481 gatttatgca agaaatacaa tttatagctc ctgcagcgtt acacgacgag atgctgcgct
     3541 tgcgaaatga aaaacagatg gactttctcg aaagcctcac cggtatggac tggggagtag
     3601 ccgatgagaa agacgctccg gaaaaactcc gcggcttagg cgtagtctac catctggaat
     3661 ctaccattac aggcgaacgg atagcactaa aaacagcgac aaccaaccgc gagctaccgg
     3721 aaattccgtc tgtcagcgac atctggaaga tagccgactt ctacgaacgt gaagtttttg
     3781 atttttatgg catcaccttt gtcggtcatc ctgatatgcg ccggctctac ctgcgcaacg
     3841 attggatcgg ttatccgatg cgtaaagata acgacccgga aaaggataac ccactgtgca
     3901 tgactaatga agagacgttt gatacgactc aagaaataga actgaacccg gacggaacca
     3961 tcaagaacaa agagacgaaa ttgttcggcg aagaagaata tgtagtcaac atcggtccgc
     4021 agcaccctgc tactcatggt gtaatgcgct tccgtgtttc tctggaaggt gaaattattc
     4081 gtaagattga tgcgaactgc gggtatatcc accgaggcat cgagaaaatg aatgaaagcc
     4141 tcacttaccc tcaaacattg gctttgacag accgtctgga ctatttgggc gcgcatcaga
     4201 accgccatgc attgtgtatg tgcattgaaa aagccatggg cattgaggtc agtgaacgcg
     4261 tacagtacat ccgtaccata atggacgagt tgcaacgtat cgattctcac ttgctgttct
     4321 actcttgtct tgctatggac ttaggagcgt tgacagcatt cttttatgga ttccgtgacc
     4381 gcgagaaaat tctcgatatc tttgaagaaa cttgcggcgg gcgtctgatt atgaactaca
     4441 atacgattgg cggtgtacag gctgatcttc atcctaactt cgtcaaacga gtaaaagagt
     4501 tcattccata tatgagagga attatccacg aatatcacga tatattcacg ggtaacatca
     4561 tcgcacagag ccgtatgaaa ggcgtcggtg tgttaagccg tgaagatgcc atctctttcg
     4621 gttgtaccgg aggtacaggc cgtgcatcag gatgggcgtg tgacgtacgt aaacgaatgc
     4681 catacggtgt atatgacaaa gtcgatttca aagaaatcgt ttatacggaa ggcgactgct
     4741 ttgcccgtta cctggtgcgt atggatgaaa tcatggaaag tctgaacatc atcgaacaat
     4801 taatagacaa tattcccgag ggaccttatc aggagaagat gaaacctatc atccgtgttc
     4861 cggaaggcag ttactatgca gcagtagaag gaagtcgtgg tgaatttggt gtcttcctgg
     4921 aaagtcaggg tgacaaaacg ccttaccgtc tgcactaccg tgctacggga ttgccgcttg
     4981 ttgctgcaat tgacaccatt tgccggggaa caaagattgc cgacttaatt gctattggcg
     5041 gaacaataga ttatgtcgtt ccggatattg acagataata cttaattatt aaaaatatat
     5101 gttcgacttt agtatagtaa caaactggat acatgagcta ctgctctcca ttatgccgga
     5161 gggattagcc atctttatag aatgtgtagc tgtcggcgtg tgcctcgtag cactgtatgc
     5221 catcctggct atcatattga tctacatgga gcgtaaggtc tgcggtttct tccagtgtcg
     5281 tcttggaccg aaccgtgttg gtaaatgggg ttctatccaa gtggtctgcg acgtgctcaa
     5341 aatgctgacc aaagaaatct tcatgccgaa gggtgccgac catttccttt ataacctggc
     5401 tccattcatg gtgattatcg cttcattcct gactttcgct tgtattcctt ttaataaagg
     5461 tgcggcgatt ctggacttca atgtgggcgt gttcttcctg ttggcagctt ccagcattgg
     5521 agttgtcggt atcttgctgg ccggttgggg tagtaacaac aaattctctt tgattggtgc
     5581 catgagaagc ggtgcacaga ttatcagtta tgaactttct gttggtatga gtatcatgac
     5641 aatggtagtg ctgacgggaa ccatgcaatt ttctgaaatc gtagaaggac aagctgatgg
     5701 ttggttcatc ttcaagggac atattcctgc ggtcattgct ttcatcatct atctgattgc
     5761 cggaaatgca gaatgtaacc gtggcccgtt cgaccttccc gaagcggaaa gtgagctgac
     5821 agccggatat catactgaat actccggtat gggtttcggt ttcttctatc tggcagaata
     5881 cttgaatctg tttatcgtag ccagtgttgc cgccactatc ttcctgggag gatggatgcc
     5941 gctgcacatt gttggtttgg atggatttaa cactgtaatg gattatattc caggctttat
     6001 ctggttcttc gccaaagcat tctttgtggt attccttctg atgtggatca aatggacttt
     6061 cccacgcttg cgtatcgacc agatcttgaa tctggaatgg aaatatctgg ttccaatttc
     6121 tatggtaaat ctattattaa tggcatgctg cgtagctttc ggcttccact tttgataaat
     6181 gaaaattatg gaatataaag ataaaaaata tacgtactta ggtggtctgg tgcatggcat
     6241 cagtacactg gcaacgggta tgaaaaccag catcaaggta tacttccgta agaaagtgac
     6301 cgagcaatat cccgaaaacc ggaaagagct gaaaatgttc gaccgttttc gtggtacgct
     6361 gaatatgccc cacaatgaga ataatgaaca tcgctgtgta gcttgcggac tgtgtcaaat
     6421 ggcctgtccg aacgatacaa tcaaagtgac cagcgaaacc gtcgaaacag aagatggaaa
     6481 gaagaagaaa atcctggcaa cctatgaata tgatttgggt gcctgtatat tctgccagct
     6541 ctgtgtcaat gcttgtccgc acgatgccat cacgttcgat cagaacttcg aacatgcagt
     6601 cttcgaccgg acgaagctcg tcctgaaatt gaaccacgac ggtagtaaag taatagaaaa
     6661 gaaaaaagaa gtttagatat gggatcaaca cttgaaacag tagtattcta ctttttggca
     6721 gcatttatta ttgcgatgtc catcatgacg gtgactaccc aacgtatcgt acgctcggcc
     6781 acctacctgc tcttcgtgct cttcggcacg gccggcatct attttttgct gggttacacc
     6841 tttctgggtt ccgttcagat tatggtttat gccggtggta tcgtcgttct ttatgtattc
     6901 tccatcctgt tgaccagcgg agaaggtgat cgcgccgaga aagcaaaacg aagtaagctc
     6961 ctggccgggc tcattaccat gattgccggt ttagcaatta tcctgactat cacgttgaaa
     7021 cataatttca tgcagacggc taatcttgcc ccgcacgaga tcaacattca tgctatcggg
     7081 aacgctttgc ttagtagcga caaatacggt tatatattac ctttcgaagc tgtcagcatc
     7141 ctgttgctgg cttgtatcat cggtggtatc ataattgcac gtaagagata aacaagtatt
     7201 aactatcaaa atagagttcg aatatgatac acatggaata ttatctggta gtttctacca
     7261 tcatgatgtt tgcaggaatc tatggattct ttacccgccg gaacacactg gctatcctga
     7321 tttctgtaga gttaatgctg aatgccacgg acatcaactt tgccgtgttc aaccgttttc
     7381 tctttccgga gggaatggaa ggctatttct ttgcactctt ttccatcgcc atctcggctg
     7441 cggaaactgc agtagccatc gccatcatga ttaacattta tcgtaatctc cgaagcatcc
     7501 aagtgcgcaa cttggacgag ctgaagtggt gatttgtttc tcaccaagaa caaataataa
     7561 taaatcaagt aataaaaata aaactgtatg gaactaacaa ttctaatact ccttcttcct
     7621 ttcttctcct ttctcatact gggaatcgga ggtaaatgga tgtcccaccg gacagcgggc
     7681 acaattggca cgctgatact gggagcagta gcggtactat cctacgttac agctatccaa
     7741 tatttctcgg ctccacgact ggaagacgga acattcgcca cactgatacc ttacaacttc
     7801 acgtggcttc cttttacaga gaccttacac tttgatttgg gcatcctgct cgatcctata
     7861 tcagtaatga tgttgattgt tatctctacc gtgtcactga tggtacatat ctactctttc
     7921 ggttacatga aaggagaagt cggttttcaa cgctattacg ctttcctatc cctgtttacc
     7981 atgtctatgc tgggattggt cgttgcaacc aacatcttcc agatgtacct tttttgggag
     8041 ctggtgggtg taagctctta cctgctaatc ggtttttatt atacaaaacc ggctgccatc
     8101 gctgcttcca agaaagcgtt tattgttact cgctttgctg acttgggctt cctgatcggt
     8161 atcctgattt acggatatta cggtggtaca ttcggattca ctccggatac agtatccttg
     8221 ataagcggtg gagcttctat gcttccgttg gctctcggac tgatgtttgt cggtggtgcc
     8281 ggtaaaagtg ccatgttccc gttgcatatc tggttgccgg atgcaatgga aggtcctact
     8341 ccggtcagcg cattgattca tgcggctacc atggtagttg ccggtgtata tttggtggca
     8401 cgtatgttcc cgcttttcat tgcctatgca ccgaatacgt tgcacatggt tgcttgggta
     8461 ggtgcattca ccgcattcta tgcagcaagt gtggcttgcg tacaatcaga tattaaacgc
     8521 gtactggctt tctctaccat ttcacagatt ggtttcatga tggtagctct gggtgtttgt
     8581 acttccatgg atcctcacga aggaggtttg ggctacatgg cttccatgtt ccacctcttc
     8641 acacatgcta tgtttaaggc attgctcttc ctcggtgcag gtagtatcat tcatgctgta
     8701 cattctaacg aaatgtccgc gatgggaggt ttacgcaaat atatgccgat cactcactgg
     8761 acattcctga ttgcttgtct tgctattgcc ggtattcctc cgttctcggg cttcttctcg
     8821 aaagatgaaa ttctggctgc ttgcttccaa tacagccctg taatgggatg ggtaatgaca
     8881 gtaattgctg cgatgactgc tttctatatg ttccgtctgt actacggtat tttctggggc
     8941 aaggaaaaca aagaactcca cgcacaccac acaccacatg aaagtccgct ggctatgact
     9001 ttcccgctga tgttcctggc agtagtaact tgtggagccg gatttattcc tttcggacac
     9061 ttcatcagtt cgaatggtga atcttattct atccatctcg atccgtcggt ggctattacg
     9121 agcgttgtca ttgcgattat ttcgattgca atcgctacat ggatgtacaa gaatgccaaa
     9181 caaccagttg ccgattcatt ggaaaaacag ttcaaaggtc tgcacaaggc tgcttataac
     9241 cgcttctata ttgacgatat ataccagttt atcacgcata agattatctt ccgctgcatc
     9301 tctactccta tcgcatggtt cgaccgtcat gtagtggatg gattctttga tttcctggca
     9361 tgggcaacca acacaacaag cgacgagatc cgtggtttgc agagcggtca ggtacaacaa
     9421 tatgcatacg tgttcctttg cggtgcactg gcacttatcc tactattaat cttataaagc
     9481 acagaacgat atgaatttct tatcaatatt cgtacttatc cccttattga tgctggccgg
     9541 actctgggca gcacgaggaa tcaaagccat ccggggggtt atggttactg gcgcatcggc
     9601 acttctgatt gcctccgtcg tacttacgtt cctgtatctg ggagagcgta gcgccggaaa
     9661 cacggcagaa atgcttttcc gtgcagatac gctttggtat gccccacttc acatatccta
     9721 ttcagtaggt gttgacggaa tttcggtagc catgttgtta ttgtccgctg tcattgtgtt
     9781 caccggtaca ttcgcttcct ggcgtctgca accgctgaca aaagaatatt tcctctggtt
     9841 caccctattg tctatgggag tattcggatt ctttatatcc gtcgatttat tcaccatgtt
     9901 catgttctac gaaatcgcgt tgataccgat gtacctgttg attggtgtat ggggatcagg
     9961 acgtaaagaa tatgcagcca tgaagctgac cctcatgttg atgggtggtt ctgccttcct
    10021 gctgatcggt attctcggaa tctattttgg ttcgggagca acgaccatga atcttcttga
    10081 aatcgcacag ttgcacaaca taccttttgc acagcaatgc atctggttcc cgctgacttt
    10141 ccttggtttc ggtgtattag gtgccctttt cccgttccat acatggagcc ctgacggtca
    10201 cgcttccgcc ccgactgccg tatctatgct tcatgccgga gtattgatga aactgggagg
    10261 ttacggatgt ttccgtatcg ccatgtatct gatgccggaa gctgctaacg aactttcctg
    10321 gatattcctg atattgacag gtatctctgt agtttacggt gcattctccg cttgcgtaca
    10381 gaccgacttg aaatatatta atgcttattc atccgtatct cactgcggac tggttctttt
    10441 cgctattctg atgctgaatc agacagcagc aacaggagct atccttcaga tgctttcaca
    10501 cggattgatg acagccttat tctttgctct tatcggtatg atttatggac gtacacacac
    10561 acgtgacgtt cgcgagcttg ccggcttaat gaaagtgatg ccgttcctta gtgtatgtta
    10621 tgtaattgcc ggtcttgcca acctcggtct gccgggatta agtggtttta ttgctgaaat
    10681 gactattttc gtcggctctt tccagaacaa caaccagttc caccgtgtac tgactatcat
    10741 cgcctgttct tcgattgtga ttactgcagt ctacattctg cgtctggtag gtaaaattct
    10801 atacggaacc tgcaccaaca aacatcatct cgaactgact gatgcgactt gggacgaacg
    10861 tgtagccgtt atctgcctca tcgtttgtgt agccggacta ggtatggctc ctttctgggt
    10921 tagccacatg attggtgaaa gtgtactccc cgtagtctca caactgattc cataaccttt
    10981 aatttttaat ctttaataat taatttgtaa atatggatta ttcacaattt ctatatatgc
    11041 gagaagagct gtcgctcata gctgtcctac tgctgctatt tctagctgac ctcttcatga
    11101 gtccggatgc acacaaaaat ggtgggaaag cacgcctgaa cacaatgttg cccgttattc
    11161 tgatggctat ccatacagct atcaacttaa ttccggggac tgctgccgat gcattcggcg
    11221 gtatgtatca ttatgtaccg atgcacacag tggttaaatc catcctgaac gtcggcacac
    11281 tgattgtttt cctgatggcg cacgaatgga tgaaaagaga agatacttca ttcaagcaag
    11341 gagaattcta tgtacttaca ctctctacct tgtttggtat gtacctcatg atttccgccg
    11401 gacatttcct gatgttcttc atcggactcg aaacagcttc tattccgatg gcagcattga
    11461 ttgccttcga taaataccgt cacaactctg ccgaagcagg tgccaaatac attctgacag
    11521 ctcttttctc cagtgcattg ctattatttg gtctgtccat gatctatggt tctgccggga
    11581 ctctttattt cgatgacctc cctgcccata tcgacggaaa tccgttacag atcatggcat
    11641 ttgtattctt cttcacagga atggcattca agttatcact ggttccgttc cacttatgga
    11701 cagcagacgt ttacgaaggt gctccgagtg cagttaccgc ttatttgagt gttatatcaa
    11761 aaggatcggc agcatttgta ttattggctg tccttatcaa agtattcgct ccaatgatta
    11821 atgactggca ggaagtactt tattgggtaa ccatcgcttc tatcactatt gcaaatatat
    11881 ttgctgtccg tcagcaaaac ctgaaacgtt tgatggcgtt ctccagtatt tcgcaagcgg
    11941 gatatattat gttaggcgtt atcggtggta cggcacaagg catgacggca ttggtatatt
    12001 atgtattagt gtacgctgcc gccaacctcg gagtatttgc cgttatcact atcgtggcat
    12061 tacgcagtca gaaattcacg ctcgaagatt acgcaggact ttataaaacg aatcccaaaa
    12121 tcgctctctt gatgactctg tctctgttct cattggcagg catccctccg tttgccggat
    12181 tcttctctaa gttctttatc ttcatggctg ctttcgatgc aggtttccac ttgctggtat
    12241 tcatcgcatt ggtaaataca gtgatttcgt tgtattacta tctattgatt gtaaaagcaa
    12301 tgtatatcac tccttccgac aacccaattc ctactttccg cagcgaccgc tgcacaaaat
    12361 ggggactggc actttgcacg ctgggtatca tcggactggg tattgcaagt attgtatatc
    12421 aatccatcga taaactgtcg ttcggaattt aaacggacta caccttttca ccaaagaaac
    12481 ggtcttggtt tcatgtcagt atcaatcgac atcaaaacca agaccgtctc ttttatataa
    12541 aacccacttt tattaatgag gaaggaagat attcacctgc ctcattacca ctctaccggg
    12601 cacagcccac ctcttccgtc acgatcaccc cgggaatagt aaaccaaaac cttgatcctt
    12661 ttcctttttc agaatcaaca ccaatccgcc cacctaattg ttcaacgatg ctctgacaga
    12721 tagaaagtcc caatcctgta ccgtgtacaa aagaattaag cttcacgaaa cgctcaaaga
    12781 tatgtggcaa ctgctctttt tcaataccga tgcctgtatc ttcaacatag aattccaatt
    12841 cgccatcttt tagtttatat cccacatgaa tactaccttc agaggtaaat ttcattgcat
    12901 tattaacaaa attagagatc acctgatgta tacggttacg gtcactaatg acatgacaaa
    12961 ccggaaggtg attatcaagt accagttcca cctcttcttt cgctttcatc cccatagagc
    13021 ggacaatatc ctcacataac agatttacat ctacatctcc gttggtaaac tcaaatgtac
    13081 ccgcttcaat cttcgacaaa tcgagtatat ctgaaattaa ttgcaacaaa agatcattat
    13141 tctcacgtac aatcttaata tactcctgac gttctgacaa ctcttcagtt tccaccaaca
    13201 aatcggagaa accgacaatg gcattcagcg gcgtacggat ttcatggctc atattggcaa
    13261 ggaaagcact tttcaaacga tccatcatct ctgctttatc gcgtgcctga atcaattcgg
    13321 cttcagtctc cttcaattct gtaatgtcat aattgatacc gatgatttct atttcatttt
    13381 cctccggttt ataattagtg accatcacat tactactcac ccaattccat tcattcttcg
    13441 ttccgggacg acgaatacgc atctcaccct gaaaatgcct tctttttccg tctctgactt
    13501 catcataaaa atcaaggaaa cgcttacggt cttcagggtg catatgggta taaacaccca
    13561 caacctcatc caaaagcgta tcttcctcct cacctaaatt cttataccac tgttttatag
    13621 catatccttt gcgattcaag agattcaact tggcataacc tacttttgca taatcggata
    13681 tcatcaggaa gaaattctca aaatcacgga tacgattcat tgcatcaatc cgttcggtat
    13741 tatcaatact tattaatata tatccgctga agttgccctc attatcatac aatttactaa
    13801 ccttcgaata cagttctatc gcattagaac gatttgtctc ataatatcct tccgcctgtt
    13861 caaaagaata attaagccta aaatctacca aatcttcatt ccgtacacga tcacgtatgt
    13921 tctgcggcac attcggatta tcaaagaagt taactccgat cacatccgac ttattcacta
    13981 caccgaatat ctccaaatcc ttattattca ggtctatcaa atagccatcc ttatcgtaga
    14041 tctctactcc tgccggaata ttagcaaata tgttctgaaa gagcttctcg ctacggtcca
    14101 atgcccggtt agcttgtacc gatcctgtag aatcgaggaa caaaccgact atttcatctt
    14161 ttccgggaga ataaataacc caatgcgtat accgttccgt tcttggaaaa tattcatctt
    14221 tctccctata agaattacta tccagtattt cttccagaaa attaagtttt tggagatagt
    14281 caggatgctt ttcagatgcc aaagaaccaa tatacgactc caaaggaagc ccgaagaagg
    14341 ttgaactgac ctcattcgca tccgtcaccc gataatcaca aggtttatta ttctcgtcac
    14401 ggataatgga catacgtata tatcccatcg gcataaaatg aaacagatta tttaggaaag
    14461 tctgttcacg gattaccttg tccttagttt tacgcagctc gatacagata tttataatat
    14521 ttcccaatga ggagaaccat tgaaaatctt cattactcca gtcatggtaa gtctcaacca
    14581 aatcaatccc catatatccc caaacgcggt cgcctgtcat caaaggagtc accattaacg
    14641 atttgattcc ctgaactaca agaatctgat attcatcagg agcctcttct aataactgct
    14701 ccagtgtatt taaaataatc ggcttgcccg ataatatctg ttcactccac cattttgact
    14761 cactggcagg catgtcctgc agattgtcta tctctgccga tactccttca gaaacaactt
    14821 cgtagataca actatgatgg gcataaattt cgtcgtattc aaaaatataa acacgacctt
    14881 tcccattata aagattcaga atatctctta aaatatctgc gatacaagat tctactgcct
    14941 catcacgtag gaaacgaagc aacgattgcg aaacaaaatt ctgacgacaa agcaaatcat
    15001 tcacacgtct taatgcatcc ctttgatctt cttccttggg agcctcaacg cgctggatta
    15061 ttccgaaaga cttatcacct ccatcaacac ctgtaccctt ttcacgaaaa gccagacggg
    15121 tatgcaacca gacctcacca tattttgaat gaatagggaa agtttgttca taaaagtcct
    15181 tatgaataga agaatttgcc cggaactcct gggcaatctg cttgcgataa tcttcacgta
    15241 tcaggttcag aaaatccgaa gtagagatgg tgtcgccgtc caatcccaaa agatcagaaa
    15301 gataatcgga acataaataa tatcctgccg ttaaatctac ttcccaccac ccgatttgtg
    15361 caagagaagc catttttctg tatcgctcgt tgtctgtctg catattttgt attattgtaa
    15421 gacaataggt tgacaaatat acaaaaaagg taatca
//
