LOCUS       c00022_gnlPro..        24639 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|HNCLKEEJ_22.
ACCESSION   c00022_gnlPro..
VERSION     c00022_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-06 04:08:41
            Original ID  :: gnl|Prokka|HNCLKEEJ_22
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 284218
            Orig. end    :: 308857
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..24639
                     /aStool="rule-based-clusters"
                     /contig_edge="False"
                     /core_location="[294218:298857]"
                     /cutoff="10000"
                     /detection_rule="(minimum(4, [AcetylCoA_hyd_C,
                     AcetylCoA_hydro, B12-binding, Biotin_lipoyl, Glyoxalase_4,
                     HMGL-like, MM_CoA_mutase, MeaB, OAD_beta, OAD_gamma,
                     PYC_OADA]) and minimum(1, [CT_Btheta, CT_Propionyl_CoA1,
                     CT_Propionyl_CoA2, CT_Propionyl_CoA3, CT_Vparvula]) and not
                     Cytidylate_kin)"
                     /neighbourhood="10000"
                     /product="succinate2propionate"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      10001..14639
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(minimum(4, [AcetylCoA_hyd_C,
                     AcetylCoA_hydro, B12-binding, Biotin_lipoyl, Glyoxalase_4,
                     HMGL-like, MM_CoA_mutase, MeaB, OAD_beta, OAD_gamma,
                     PYC_OADA]) and minimum(1, [CT_Btheta, CT_Propionyl_CoA1,
                     CT_Propionyl_CoA2, CT_Propionyl_CoA3, CT_Vparvula]) and not
                     Cytidylate_kin)"
                     /neighbourhood="10000"
                     /product="succinate2propionate"
                     /protocluster_number="1"
     cand_cluster    1..24639
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(minimum(4, [AcetylCoA_hyd_C,
                     AcetylCoA_hydro, B12-binding, Biotin_lipoyl, Glyoxalase_4,
                     HMGL-like, MM_CoA_mutase, MeaB, OAD_beta, OAD_gamma,
                     PYC_OADA]) and minimum(1, [CT_Btheta, CT_Propionyl_CoA1,
                     CT_Propionyl_CoA2, CT_Propionyl_CoA3, CT_Vparvula]) and not
                     Cytidylate_kin)"
                     /kind="single"
                     /product="succinate2propionate"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..24639
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="succinate2propionate"
                     /region_number="1"
                     /rules="(minimum(4, [AcetylCoA_hyd_C, AcetylCoA_hydro,
                     B12-binding, Biotin_lipoyl, Glyoxalase_4, HMGL-like,
                     MM_CoA_mutase, MeaB, OAD_beta, OAD_gamma, PYC_OADA]) and
                     minimum(1, [CT_Btheta, CT_Propionyl_CoA1,
                     CT_Propionyl_CoA2, CT_Propionyl_CoA3, CT_Vparvula]) and not
                     Cytidylate_kin)"
                     /tool="gutsmash"
     CDS             237..1751
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) AMP-binding"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1025:AMP-binding enzyme (Score: 268.6; E-value:
                     2.5e-82)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg22_228"
                     /sec_met_domain="AMP-binding (E-value: 1e-81, bitscore:
                     268.6, seeds: 145, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTTSSQKDIINDILSAMQCYPENEAFIIDDKHYTYAQLGEITASI
                     THSLSEIKDEKIGIVAENRIETYAAILAVLAGGKTYVILHPAYPEERNLKIAALAGLRT
                     LLCTSDTDRSAFGTGHFRIIDTDRLPGKTLSEQQSHSSDEERNAYIIFTSGSTGEPKGV
                     PITRANLNAFYRAYSSLDWNLDEHDRMLQMFELTFDVSVVSLLYPLTLGAAVYTVGHQD
                     VKHFKVFELLEKYQLTFATVTPSLLQLLSPYFDEINLPSLKYLGVSAEASQIELLERFR
                     KSAPNATFINLYGPTEATIYCTCYRIPASDKCKHYNGMVAIGKPFPGIRAIIADEEGNE
                     LPQGETGELWVSGRQVMKGYLDDPEKSALVLIHRPDGQIYYRTGDLCILDGDGDIIYCG
                     RKDYQVKIQGFRIELSEIEYTAQSFFKTPCSVAAVPLLCDGICNELHLAVETTECTQSA
                     LIEYLKEKLPKYMLPKQIHCISQFPVTNSNKTDRKKIAELIKEKKL"
     CDS             1766..2008
                     /locus_tag="ctg22_229"
                     /transl_table=11
                     /translation="MNREEVLKQLQSIFRNILKKDNVCIDESSTSKDVDGWDSLTHMQI
                     IAQIEKHFGVRFNFREVIKFKNVGDLCSALLTKME"
     CDS             2012..3394
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) MBOAT"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg22_230"
                     /sec_met_domain="MBOAT (E-value: 2.3e-21, bitscore: 70.5,
                     seeds: 20, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MQFLSFSFLALFTLCFFLYYAVKGRARNLILLVTSCIFIGWYYLP
                     FLLTAVVVALFTFFWAQWMESRAKAGKKTKPVYIAGIIALIGGWLLLHGTVIDDIIFPL
                     GMSFYTFQAISYLTDVYWQEQRSERNWVDFLIYMLFFMKFLSGPIERGGDLLPQLKDPR
                     PFIYSNAVTGLKYILLGLIKKLLIANQISPQTDVMFHSIHDLSGVQLLMTCLLYPIELY
                     ADFSGYTDIAIGGAYMFGIKLSPNFNRPFAARSTADFWRRWHMSLSFWVRDYLYVPLTA
                     GTRNWGQWGIYFSLLITFLALGLWHGAGLTFAIYGLIQGVLICWEMKTAAFRNNLPQYI
                     GKYAADSLLIVRTYLLFALSLIFFRVQSLSDAWYFLRNISFEVHSSWKEMNIGIRDHNC
                     IVAGSALLLVLIYEYYASKYNLMETLERQPAWLRWSVYYLLVFALLMLGKFDTETFIYL
                     QF"
     CDS             3413..4453
                     /locus_tag="ctg22_231"
                     /transl_table=11
                     /translation="MLHHSSRISPKTRFCLKLLLLILPLIPIVVVYFMFDPYRVLHPYK
                     RFDDSPMLLNEAHVGWQNYLQNRDSIAYNSFILGNSCTMAFLTGEWEKYLDKNDHAVRF
                     YDNGESLGGVRQKLQLLDSVGAPLKNVLIVLDKKSLDKNAPLSGNNHLFSAEAAGISQL
                     GFQLRFLQEFLYPDRMIPYIDYLIRHKYAPYMKGVINPGDPVREPYTNNFINPREKEIA
                     QDGEIYWSRHEKEFKKRTNAGMEELPVIFASQIQVLRSIKKICDKHHTNLKFIIGPDYY
                     QKKTSREDIKILKAILGDSAVWDFTGINEYTADIHHYYEPGHYRPLLGARLLKAIYQDQ
                     DTCHRQ"
     CDS             4558..4950
                     /locus_tag="ctg22_232"
                     /transl_table=11
                     /translation="MKKILLLLSVCISFSSCCTLFSSSKQDITFTGMNGTKIYEASTKQ
                     KIAEIKEDNSVTVQIKKKREDKQLVAKKEGYQTTPFVLESTFNNACLWNILFWPGFLVD
                     LGTQKMNKWDNTIINIEMEKENTENK"
     CDS             complement(5143..5772)
                     /locus_tag="ctg22_233"
                     /transl_table=11
                     /translation="MLSDGDFQYIPYLFISMLANLDRYKIVLASNSPRRKELMTGLGVD
                     YVVKTLPDVDESYPDTLQGEEIPLFIAREKAAAYQSMIGPEELLITADTIVWHEGKALG
                     KPVGRQDAIEMLRSLSGKSHQVITGVCVTTREWQKCFAAVTDVRFAILDEDEIAYYVDH
                     YQPMDKAGSYGVQEWIGFVGVESISGSYFNVMGLPIQKLYRELKQL"
     CDS             complement(5756..6277)
                     /locus_tag="ctg22_234"
                     /transl_table=11
                     /translation="MSTINYDLTRIKALAFDVDGVLSANVIPLHPSGEPMRTVNVKDGY
                     AIQLAVKKGLRIAIITGGRSDVVRKRFIGLGVSDLYFGSAVKIHDYRGFRDKHGLTDEE
                     ILYMGDDVPDMEVMRECGLPCCPKDAVPEVKAIARYISYADGGYGCGRDVVEQVLKAQG
                     QWLSDDAFGW"
     CDS             complement(6298..7089)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) F420_oxidored"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg22_235"
                     /sec_met_domain="F420_oxidored (E-value: 4.1e-13, bitscore:
                     43.8, seeds: 48, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKRSIEDTPIVFIGAGNLATNLAKALYRKGFRIVQVYSRTEESAR
                     ELAQKVEAEYTTDLAEVNPYAKLYIVSLKDSAFAELLQGIVEGKREEALMVHTAGSIPM
                     NVWEGHVPHYGVFYPMQTFSKQREVDFKEIPFFIEASSAEDAAFLKAIASTLSNRVYDA
                     DSEQRKSLHLAAVFTCNFTNHMYALAAELLKKYNLPFDVMLPLIDETARKVHELEPKTA
                     QTGPAIRYDENVIGNHLRMLADDPAMQRLYELLSRSIHERQ"
     CDS             complement(7086..7418)
                     /locus_tag="ctg22_236"
                     /transl_table=11
                     /translation="VSAVKANNKDTYKATAVTLIVMGVLYLIDKLIHFSTLGIPWVMNK
                     DNLLLYTAVIFLFIKRDKSVGLVLLGLWLVLNIGLIVSLLGSMSGYLLPLALLIIGGIL
                     YLISTR"
     CDS             complement(7421..7918)
                     /locus_tag="ctg22_237"
                     /transl_table=11
                     /translation="MRKFTGEELSQEDVVALLKAALMAPTSKRSNSWQFIAVDDKKLLS
                     ELSHCKEQASAFIADAALAIVVTADPLASNVWIEDASIASIMIQLQAEDLGLGSCWVQV
                     RERYTATGMPSDEFVRGVLDIPLQLQVLSVIAIGHKGMERKPFNEDHLQWEKIHINKFG
                     GK"
     CDS             complement(8124..8666)
                     /locus_tag="ctg22_238"
                     /transl_table=11
                     /translation="MLEEILEFNKKFVENRGYEKYITNKYPDKKIAILSCMDTRLTELL
                     PAALGIHNGDVKIIKNAGAVISHPFGSVIRSLLVAIIELGVEEVMVIAHSDCGACHMNS
                     DEMIAHMKKRGIKSETIDMIRYCGVDFNSWLGGFDDPVKSVRGTVRSIENHPLIPKDVR
                     VHGFIIDSLTGELTRVE"
     CDS             8784..9767
                     /locus_tag="ctg22_239"
                     /transl_table=11
                     /translation="MPLKLTTYYQGSEIPDFPGTNTFHSKELFQIYEETPGYTPLLIMA
                     SEDGKPVARLLAAIRKSIRMFPPAFIKRCEIYGTGEYLIAEADKERIFGEMLEHLTTEA
                     LRNSFLIEFRNLENAMFGYKYFRSNRYFPVNWLRVRNSLHGIENAEQRFSPSRIRQIKK
                     GLKNGAKVDEARTVEEIREFSNMLRHLYSSRIRKHFPNIIFFQHMDTRLIHSRQAKIFI
                     VRYKDKIIGGSACIYSGNDAYLWFSGGMRKTYALQYPGILAVWKALRDAHQNGFRHMEF
                     MDVGLPFKKHGYRDFVLRFGGKQSSTRRWFRFRWQWLNDLLIKIYV"
     CDS             10001..10405
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: Glyoxalase_4"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg22_240"
                     /sec_met_domain="Glyoxalase_4 (E-value: 5.5e-23, bitscore:
                     75.4, seeds: 51, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKISHIEHLGIAVKSIEEALPYYENVLGLKCYNIETVEDQKVRTA
                     FLKVGDTKIELLEPTCPESTIAKFIENKGAGVHHVAFAIEDGVANALAEAESKEIRLID
                     KAPRKGAEGLNIAFLHPKSTLGVLTELCEH"
     CDS             10531..12084
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: CT_Btheta"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg22_241"
                     /sec_met_domain="CT_Btheta (E-value: 5.2e-290, bitscore:
                     955.9, seeds: 72, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSNQLEKVKELIELRAQARLGGGEKAIEKQHAKGKYTARERIAQL
                     LDEGSFEELDMFVQHRCTNFGQEKKHFLGDGVVTGYGTIEGRLVYVFAQDFTVFGGSLS
                     ETMAQKICKVMDMAMKMGAPVIGINDSGGARIQEGINALSGYAEIFQRNIMASGVIPQI
                     SGIFGPCAGGAVYSPALTDFTLMTEGTSYMFLTGPAVVKTVTGEDVSQEDLGGASVHAS
                     KSGVTHFTAETGEEGLAIIRKLLSFIPQNNLEEAPLVNCTDPIDRMDDLLNEIIPDSPN
                     KPYDMYEVIGAIIDNGEFLEVQKDYAKNLIIGFARMNGQSVGVVANQPKYLAGVLDSNA
                     SRKGARFVRFCDAFNIPLVTLVDVPGFLPGTGQEYNGVILHGAKLLYAYGEATVPKVTV
                     TLRKSYGGSHIVMSCKQLRGDMNYAWPTAEIAVMGGAGAVAVLYAKEAKDQENPAQFLA
                     DKEAEYTKLFANPYNAAKYGYIDDVIEPRNTRFRVIRALQQLQTKKLTNPAKKHGNIPL
                     "
     CDS             12105..13019
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: OAD_gamma"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg22_242"
                     /sec_met_domain="OAD_gamma (E-value: 3.2e-15, bitscore:
                     50.6, seeds: 234, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNKKRIGIFIALLAMVCMGLRAQSATSLRINEVLVVNDQNYQDDY
                     GLHNAWIEIFNTSFASVNLEGCFLTNDKNNPTKYPIPKGDVLTLIKPRQHALFWADGMP
                     NRGTFHVNFTLDPNKENYIALYDSNGKTLIDEVTIPAGQLADRSYAREKDGSANWVVKG
                     EGEHSYVTPSTNNMTIDKNPKIENFKKHDSIGIGMAIIAMSVVFIGLVLLYLSFKAVGN
                     VAVRLGKKNAMKATGITDKTEAKEKNLGSHTGEETAAIAMALHEYLNDAHDVEDMILTI
                     NKVKRTYSPWSSKIYTLRQTPKR"
     CDS             13045..13476
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: Biotin_lipoyl"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1024:Biotin-requiring enzyme (Score: 69.7; E-value:
                     4.8e-22)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg22_243"
                     /sec_met_domain="Biotin_lipoyl (E-value: 2e-21, bitscore:
                     69.7, seeds: 40, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKQYKYKINGNLYNVTVNDVEDNIANVEVNGTSYKVELDKPVKAA
                     PKPVTRPAAAPKTETGAPVVTKQPTASKKDGVKSPLPGVILDIKVKEGDTVKRGQTIII
                     LEAMKMENNINANKDGKVAEIKVNKGDSVLEGTDLVIIE"
     CDS             13479..14639
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: OAD_beta"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg22_244"
                     /sec_met_domain="OAD_beta (E-value: 1e-152, bitscore:
                     502.1, seeds: 229, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MGDFVSFLGNNLVDFWGYTGFANATPGHLFMLLIGLFFIYLAVAK
                     EFEPMLLIPIGFGILIGNIPFNMEAGLKVGIYEEGSVLNILYQGVTSGWYPPLIFLGIG
                     AMTDFSALISNPKLMLIGAAAQFGIFGAYIIALLIGFEPNQAGAIGIIGGADGPTAIFL
                     SSKLAPNLMGAIAVSAYSYMALVPVIQPPIMRALTTKHERLIRMKPPRIVSHTEKVIFP
                     IVGLLLTCFLVPSGLPLLGMLFFGNLLKESGVTRRLANTASGPLIDVITILLGLTVGAS
                     TQASQFLTWDSILIFILGAFSFIIATASGVMFVKFFNLFLKKGNKINPLIGNAGVSAVP
                     DSARISQVIGLEYDPTNYLLMHAMGPNVAGVIGSAVAAGILLGFLM"
     CDS             14787..16007
                     /locus_tag="ctg22_245"
                     /transl_table=11
                     /translation="MRTRTMKPLFLIFCLCLSPLLMGQNQNKIQEAMANYDYETAVELI
                     NKEPPTIPLLMQKAKALKGIGSNAEALRSIRQVIAEDSTNQQAHIEAAECCKAMAKYND
                     ALDYYRKAISLNPKNKYARLQFINLLCNTKNYAEAFGESSMMSETDSSAVVLHLQAQSL
                     EGMQQILPAIGCYEVIQDKYPDDYLAAAKLGNLNIVAGYPEYAIQATERYRERDSTNLI
                     VNQQNALAYCHAEQYPTAIKRYEKLCQQGDSSTQTLYYLGVSYYADEYYYEAHACFSKL
                     QKEMEENPNLLYYLGRCCAKTSWKKEGIEHLEKAIELTIPKDSTMIRLYKGLVDCCKLA
                     QDTPKQIQALRELYKYDKTNHKLLYDIAWNYSYQLKDNKSAERYLQAFLKTRKANARKE
                     EPVSEKG"
     CDS             16133..17425
                     /locus_tag="ctg22_246"
                     /transl_table=11
                     /translation="MKHWILLLYLGFSVVLQAQNTASVQEAMANYDYKTVIRLIDEESA
                     SPQLLIQKAKALKGLGRTAEALSTLQHIIIELPENQQALVEAAECCRQLSKFNEALGYY
                     RKVMELNPEHIYAHLQYTRLLYNYQRYGDALRESIALARKDSSATVLRLMAESMEGAGM
                     PVESMFCYLSIIRKYPSDYLSVAKLGSIFNTMKDYEGAIALTEAYRRTDSTNVEVNRQN
                     ALAYCLRKEYPTAIKRYQDLTARGDSTLLTCYYLGVSYYATKEYYKARDWLLKAKSCQS
                     PGANLLYYLGRSCSKTLWKQEGIGYLNQAIALTIPADSIMERLYSGLADCYRQTKQTRD
                     QIKATKEQYKYAPDKHILLYNLAFLSDKIGDTKATEHYLQAFLRTKSKQNAVLQQPDDD
                     EEEPAPYIDYYKSATNKLESIRKEKFLKGEK"
     CDS             17951..19801
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Alpha-amylase"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg22_247"
                     /sec_met_domain="Alpha-amylase (E-value: 1.4e-62, bitscore:
                     206.2, seeds: 19, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKKLLLLLGSFLLSLTTYAAMNISKIDPPFWFTGMNNPELQLMVY
                     GEGIGQASVSVNYPGVSLSSVVKLESNNYLLVYLHLDKEVKPGKMPITFTVGKKKLVKE
                     YELKARSKAGVDHKGFDASDALYLLMPDRFANGNPDNDRIEGMAEYKVDRNDPNARHGG
                     DLAGIEQNLDYFTDLGVTALWFTPVLENNMKGGSYHGYATTDYYKVDPRFGTNEEYRSL
                     IAKAHNRGIKVVMDMIFNHCGVEHPWIKDMPSKDWFNHADFKNNFVQTSYKLTPHVDPY
                     ASEYDFDQMNNGWFVEAMPDLNQKNPHVYKYLLQNSLWWIEYADIDGIRMDTYPYADYD
                     AMSNWMKELNEEYPNYNTVGETWVTEPAYTAWWQKDSKLSAPRNSHLKTVMDFSFFDKV
                     NTAKNEQTDTWFKGLDRVYNNFVYDYLYPNPASVLAFIENHDTDRFLGEGENLDMLKQA
                     STLLLTTRRIPQLYYGTEVMMNGVKSKSDGYVRKDFPGGWTDDKENALTPEGRTRLQNE
                     SYNFYRNLLNWRKGNDVIAKGSMKQFMVQHGVYAYARQYKGKTVFVLLNGTDKEVKLPL
                     KYYAEVLKDKTQGKDVISGKVTALNEELTMAPRQSMVIEL"
     CDS             19959..20399
                     /locus_tag="ctg22_248"
                     /transl_table=11
                     /translation="MTNNESERELVLQTLRTWMAFRQAVQRVLKRHNVDMTFEMLQVMN
                     CLWNKQGISQQSLAEKTAKDKACLTNLINNLEKKNWVIRKEGPSDRRNRLIFLTPQGEE
                     LALTVKPLINDIYAQTGAEMEASRITECIEDLKRLHEVLNEI"
     CDS             20412..21479
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Biotin_lipoyl_2"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg22_249"
                     /sec_met_domain="Biotin_lipoyl_2 (E-value: 5.6e-11,
                     bitscore: 36.2, seeds: 52, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSTHQIKLKQLRRLKFRNIFLNTVCILLALAGISWTVNYFWKYAR
                     YEITNDAVVDQYIAPLNIRIPGYIKEVRFTEHQYVHAGDTLLILDDREYRIRLKDAEAA
                     LMDALGSKEVLNSGIRTSGVNVAVQEANIAETLARLSQQEAELNRYTRLLKKQAVSQQD
                     YELAKANFEATRARYNALLRQKEAAQSQYSETSKRSTGAEANILRKEADLEMAKLNLSY
                     TVVTAPYDGYTGRRTLEPGQFVQGGQTLSYLVRGNDKWVTANYKETQIAHIYIGQKVRI
                     KVDAFSGRTFHGTVTAISEATGSKYSLVPTDNSAGNFVKVQQRIPVRIDLNDASPEEME
                     CLRAGMMVETEAVRP"
     CDS             21484..23079
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) MFS_1"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg22_250"
                     /sec_met_domain="MFS_1 (E-value: 1.6e-13, bitscore: 44.3,
                     seeds: 192, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MVKLNLPTRPWVPQWLGIVTMFIVIFPITLLNGAYTGSMVEVSNT
                     LGVLSEDITMAYYSASVGMAVAYPIVPKIRTIATPKTLLLTDLLLQIFFSLVCAQTGSM
                     DVIMVCSFCMGFLKAFVMLEFIILIRPLFSPKNVRSEFYAYFYPIVFSGGQLSMAITAQ
                     LAYHYQWQHMYYFVTILLLIAILFVICFFRYARRPMHIPFKEMDGRSMFIIATAFLLTL
                     YTFTYGKTLDWFASPKIRVYVFVIPLLIVLFIHRQRTQGKPFVSLKPLFLHKSIIGYGF
                     MVLAMFLTATSSLVTNYMNSIIRVDSIHANSLSLWLLPGYVVGAVICFWWFRWQRWRFR
                     FLISGGMFCYVIYLAILYFGITPYGTYEMLYLPILFRGVGMMVIFIAFGVFVVEDLDPR
                     LTLSNAFFLISFRSVLAPVLSASFFNNMLYYLQAKGMNILSENMTLTNPLAEQKYNQAL
                     SNALAQGHEFSEAGQLAANSLYSTLQQQSLLLALKTLIGYVLILALVIAVIAAFIPFHK
                     TLKVAVVKTGDDMV"
     CDS             complement(23174..24178)
                     /locus_tag="ctg22_251"
                     /transl_table=11
                     /translation="MVNYKDLGLVNTRDMFAKAIKGGYAIPAFNFNNMEQMQAIIKAAV
                     ETKSPVILQVSKGARQYANATLLRYMAQGAVEYAKELGCKNPEIVLHLDHGDTFETCKS
                     CIDSGFSSVMIDGSHLPYDENVALTKKVVEYAHQFDVTVEGELGVLAGVEDEVSSDHHT
                     YTEPDEVVDFVTKTGCDSLAISIGTSHGAYKFTPEQCHIDPKTGRMVPPPLAFDVLDGV
                     MKELPGFPIVLHGSSSVPEEEVATINQFGGALKAAIGIPEEELRKAAKSAVCKINIDSD
                     SRLAMTAAIRKVFAEKPAEFDPRKYLGPARDNMEKLYKHKIINVLGSDNKLAE"
ORIGIN
        1 tatcaataaa gtatcgtgtt gtctatccca ttcaaagtcg tcggctatga agccaacgct
       61 atttcccctt ccgaaagagg gaaagcgaga ccgggcacgt gcgtaccaca caattaacat
      121 tctttaatcg attgtgcgta gggagatcag accatttcac tgtcatctta ataaacgatc
      181 tcaagaagat atataaagaa cccctaaacc caaaacatga ataaaaacta atggatatga
      241 caacatcttc ccagaaggat attatcaatg atattctttc cgccatgcaa tgttatcccg
      301 aaaacgaagc attcattatt gacgataaac attatactta tgcccaactc ggtgaaataa
      361 cagcttctat cacccattcg ctatcagaaa taaaagatga aaaaatcgga atcgtagcgg
      421 aaaaccggat tgaaacctat gctgctattc tggcagtact agccggcgga aagacctatg
      481 ttatcctgca tcctgcctac ccggaagagc gtaatctcaa aatagccgct ctggccggac
      541 tgcgtacttt gctctgtaca agtgacactg accggtcagc attcggcacc ggacacttca
      601 gaatcatcga tacggaccgg ctaccgggaa aaacactgtc agaacagcag tcccattcat
      661 cggacgaaga aaggaacgct tatatcattt ttacatcggg aagcacaggc gagcccaaag
      721 gagtgcccat cacacgggct aacttgaacg ccttttaccg ggcatacagt tcgctcgact
      781 ggaatctgga tgaacatgat cgcatgttgc aaatgttcga acttacattc gatgtatccg
      841 tagtatcttt actgtatcct cttactttag gtgctgccgt ttatacggta ggccatcagg
      901 atgtaaagca cttcaaggtg tttgaacttc tggagaagta tcaactgacc tttgccactg
      961 tcactccctc actgctacaa ctcctttcac cctacttcga cgaaatcaat ctgccctctc
     1021 tgaaatatct gggagtatcg gcagaagcat cgcaaatcga gctgttggag cgattcagaa
     1081 aatcggcacc caacgcaacg ttcatcaacc tatacggacc gaccgaagct acgatttact
     1141 gcacctgtta ccgtattccg gcttcggaca aatgcaagca ttacaacgga atggtggcta
     1201 tcggaaaacc atttcccggc atccgcgcca tcattgccga cgaagaagga aacgagctac
     1261 ctcaaggaga gacgggagaa ctttgggtat ccggccggca ggtaatgaaa ggttatctgg
     1321 acgacccgga aaaatcggca ttggttctga tacaccgtcc cgacggacaa atctattacc
     1381 ggaccggaga cttgtgtatt ctggatggcg acggggatat tatttattgc ggacgtaaag
     1441 actatcaggt gaaaatacag ggtttcagga tagaactgag tgaaatagaa tatactgccc
     1501 agtcgttttt caagactccc tgcagcgtgg ctgccgttcc gttgctctgc gacggaatct
     1561 gtaacgaatt gcacctggcc gtcgagacaa ctgaatgtac tcaaagcgca ttgatagaat
     1621 atctgaaaga aaaactgccc aaatacatgc tgccgaagca gattcattgt atttcccaat
     1681 ttccggtgac caatagtaat aaaacagacc gtaaaaagat tgccgaactg ataaaagaga
     1741 agaaactcta aaaacaataa taaatatgaa tcgagaagaa gtattaaaac aactacaaag
     1801 cattttccgt aatatcttaa aaaaggacaa cgtatgtatc gacgaatcat ctacctcaaa
     1861 agatgtagat ggctgggact cgctaaccca catgcaaatt atagctcaaa tcgagaaaca
     1921 tttcggagta cgtttcaatt tcagggaggt cattaagttc aagaatgtcg gcgatttgtg
     1981 cagtgcctta ttaaccaaaa tggaataaac gatgcagttc ctctctttta gtttcctggc
     2041 cctatttacc ctctgtttct tcctctacta tgcagtcaaa ggccgtgccc gcaacctcat
     2101 actactggta accagttgta ttttcatcgg atggtactat ctgcctttcc tgttgacggc
     2161 agtagtggta gcactgttca ccttcttttg ggcacaatgg atggaaagca gggcaaaagc
     2221 cggaaaaaag accaaacccg tctatatcgc aggaatcatc gccctgatcg gcggatggct
     2281 ccttcttcat ggcacggtca tagatgatat catctttcca cttgggatgt cattttacac
     2341 atttcaagcc atcagttatc tgacagacgt gtactggcaa gagcaacgca gcgaaagaaa
     2401 ctgggtggat ttcctgatct atatgctttt cttcatgaag tttctctccg gccctatcga
     2461 acggggtgga gacctgttgc cacaattgaa agatccccgc ccgttcatct actcaaacgc
     2521 ggtgaccgga ctgaaatata ttttactcgg actgatcaag aaactgctga tagccaatca
     2581 gatctcccca caaacagatg tcatgtttca ttcgattcat gacctctcgg gtgtacaact
     2641 gctaatgact tgcctactct accctatcga actgtatgcc gatttttcgg gttatacgga
     2701 tattgctatc ggaggggcct atatgttcgg catcaagttg tcgcccaact tcaaccgccc
     2761 gtttgcagca cgctcgactg ccgacttctg gcgccgttgg cacatgtcac tctccttctg
     2821 ggtacgcgat tatctctatg taccgctaac cgccggtacc cgtaactggg gacagtgggg
     2881 aatctacttc agcctcctca tcacctttct cgcattgggt ttgtggcatg gggccggatt
     2941 gactttcgcc atatacggcc tgattcaggg tgtccttatc tgctgggaaa tgaaaacagc
     3001 tgctttccgc aataatctgc cccaatatat aggaaaatat gcggccgaca gcttgctgat
     3061 tgtccggact tatctattgt tcgcactctc gcttatattc tttcgtgtac aatcgctgag
     3121 cgatgcctgg tatttcttac ggaacatctc gttcgaggta cattcttcct ggaaagaaat
     3181 gaacatcggc atacgcgatc ataattgcat cgtagcaggt tcggccctat tactagtatt
     3241 aatctacgaa tattatgcat ctaagtacaa cctgatggaa acacttgaac gccaacccgc
     3301 atggttacgg tggagtgtct actatctgtt ggtattcgct ctgctgatgt taggcaaatt
     3361 tgacacggaa actttcatct atttacaatt ttaaccgaaa ccctttacgc gcatgctaca
     3421 tcattcatcg agaatctccc ccaagacacg tttttgcctg aagttgcttt tactgatcct
     3481 gccgctgatc ccgatagtgg ttgtctattt tatgtttgat ccttataggg tattacaccc
     3541 ctacaaacga ttcgacgact ctcccatgct actcaacgaa gcccatgtgg gatggcagaa
     3601 ttatctgcag aatcgcgatt cgatagccta taactccttt atactcggca actcctgtac
     3661 catggcattc ctgacaggag aatgggaaaa atacctggat aagaacgacc atgccgtacg
     3721 cttctatgac aacggagaaa gcctgggcgg cgtccgtcaa aagcttcagc tgctcgactc
     3781 tgtaggtgca cccctgaaaa atgtactgat cgttctggat aaaaaatcac tggacaaaaa
     3841 cgctccttta tcgggcaaca atcatctgtt ttcggccgaa gcagccggca tcagccaatt
     3901 gggattccag ttgagattcc tgcaggagtt cctttatccg gacagaatga ttccttacat
     3961 agattatctg atccgacata agtatgctcc ttatatgaaa ggggttataa atccgggaga
     4021 tcccgtcagg gagccttaca cgaacaattt tatcaatccc agagaaaaag agatcgcgca
     4081 agatggcgaa atatactgga gccgtcatga aaaagaattc aagaagcgaa cgaatgcggg
     4141 tatggaagaa cttcctgtta tatttgccag ccagattcag gtacttcgct ccatcaaaaa
     4201 aatctgcgat aagcaccaca cgaacctgaa gttcatcatc ggtccggatt actatcagaa
     4261 aaagaccagc cgggaagaca taaaaatatt gaaggctata ctgggtgatt ccgctgtctg
     4321 ggatttcacg ggaatcaacg aatacacagc cgacatacat cattattacg aacccggtca
     4381 ttatcgtccg ctgctgggag cacgcttact gaaagccatt tatcaggatc aagacacctg
     4441 ccacaggcaa taaaagttcc tcccataaca gtagcacaca cagaagaaga gcatcctcga
     4501 tccgaaagaa ataattagat caaagaaaac aattatatca cattaaaaac ttagattatg
     4561 aaaaagattt tattattgct atccgtctgt atttcatttt catcatgctg tacattattc
     4621 agcagttcca aacaagatat cacctttacg ggaatgaatg gaactaaaat ctacgaagca
     4681 tcgaccaaac agaaaatagc ggaaatcaaa gaagacaata gtgtcactgt acaaatcaaa
     4741 aagaaaaggg aagacaaaca actagtagcc aaaaaggaag ggtaccaaac gactcccttt
     4801 gtcctggaat ctacatttaa caatgcctgc ctgtggaaca ttctattttg gccgggcttt
     4861 ctggtagatt tgggtacgca aaagatgaac aaatgggata acacaattat caatatcgaa
     4921 atggagaaag aaaatacaga aaacaaatga tcaaactata atttcgcatg gcactcttct
     4981 ccttccacgg agggagtcgc catacggaat catgcgacct acaaggaagg cataattcac
     5041 cacaaggcaa cacagagttt tttataaaag ttctttagag aataaatcta ctctgtgaga
     5101 ctctgtgcta ctccgttgta tatacgagtt tcggcacact ctctatagtt gtttcaattc
     5161 tctgtataat ttctgaatgg gaagtcccat tacattgaag tagctgccgg atatggattc
     5221 tactccgaca aaaccgatcc actcctgcac accatacgaa ccggctttgt ccatgggctg
     5281 atagtgatcg acataataag cgatttcatc ttcatcaaga atcgcaaaac ggacatccgt
     5341 cacggcagcg aaacattttt gccattctcg ggtagtgaca cacacaccgg taatcacttg
     5401 gtgcgattta ccggagaggc tccgcaacat ctctatggca tcctgccttc cgacaggttt
     5461 gccgagcgct ttgccttcat gccagacaat ggtatcggct gtgatcaaaa gctcttccgg
     5521 tccgatcatc gactgatagg cggctgcctt ctcacgggct atgaaaagag gaatctcttc
     5581 accttgcaac gtatcgggat aagattcgtc cacatccggc aaagttttta ctacataatc
     5641 gacacccaag cccgtcatca gctctttccg acgcggagaa ttagaggcca atacgatttt
     5701 ataacgatct aagttagcaa gcatactgat aaataaataa ggtatatact ggaaatcacc
     5761 atccgaaagc atcatcggac aaccattggc cttgtgcttt aagcacctgc tccaccacat
     5821 cgcgtccaca gccgtatcct ccatcggcat acgaaatgta acgggcaatc gctttcacct
     5881 cgggaaccgc atctttggga cagcagggca atccgcactc acgcatcact tccatatcgg
     5941 gaacgtcatc gcccatgtag agtatctcct cgtccgtaag tccgtgtttg tcacggaaac
     6001 cacgataatc gtgtatcttc accgcagagc cgaagtacag atcggatacc cccaacccta
     6061 taaaacgttt ccgcacgaca tcgctccgcc cacctgtaat aatagcgata cgaagccctt
     6121 tttttacggc caattggatg gcataaccgt cttttacatt taccgtacgc atcggttcac
     6181 ccgacggatg caaagggatg acattggcgc tcagcactcc gtctacatcg aaagcaagtg
     6241 cctttatccg ggtaaggtcg taattgattg tgctcatttt tatttaatgt ttcgggatta
     6301 ttgtctttcg tgaatgcttc ggctaagcaa ctcgtataac cgctgcatgg caggatcatc
     6361 ggcaagcatc cgcaagtgat tgccgatcac attctcgtca taacggatgg ccggcccggt
     6421 ctgggccgtc ttaggttcca gttcgtgcac cttacgggcg gtttcatcaa tcaacggcaa
     6481 catcacgtca aacggcagat tgtatttctt aagcaactcg gcagcaaggg catacatgtg
     6541 attggtgaag ttacatgtaa acacggcagc cagatggaga cttttacgct gctccgagtc
     6601 ggcatcgtac acacggttgg acagtgtaga ggcaatggct ttcagaaacg cggcatcttc
     6661 tgccgaagaa gcctctatga agaaaggaat ctccttaaaa tctacctccc gctgcttgct
     6721 gaaagtctgc atgggataga acacaccgta atgcgggaca tgtccttccc agacattcat
     6781 cgggatgcta cctgccgtat gcaccatcaa tgcctcttcc cgcttacctt cgacaatgcc
     6841 ctgaagaagt tcggcaaagg cggaatcttt cagtgaaaca atatacagct tcgcatacgg
     6901 gttcacctct gcgaggtctg tcgtatattc ggcttccact ttctgtgcca gttcgcgggc
     6961 cgactcttcc gtacggctat acacctgtac gatacgaaaa cctttccgat ataaggcttt
     7021 tgccagatta gtggcaagat ttccggcacc gataaatacg atcggcgtat cttctatact
     7081 tcttttcatc gtgttgaaat caaatacaat atacctccga ttatcaataa agccaaaggc
     7141 agcagataac cggacatcga accaagcaac gaaacaatca ggccgatgtt cagcaccaac
     7201 cacaatccga gcaataccaa gccgacggat ttatcccgct taataaacag gaaaatcacc
     7261 gcagtgtaaa gcaaaagatt atccttattc atcacccagg gtatccccaa agtggaaaag
     7321 tgtatcagtt tgtcgatcag atagagcacc cccatcacaa taagggtgac tgctgtggct
     7381 ttgtaggtat ctttattgtt tgcttttacc gcactcaccg ttacttacct ccgaacttat
     7441 taatatggat tttttcccat tgcaaatggt cttcattaaa gggtttacgt tccatccctt
     7501 tatgcccgat cgctatgacg gacaacacct gcaactgcaa aggaatgtcg agcacaccgc
     7561 gcacaaattc atcggaaggc atcccggtgg cagtatatcg ctcacgcacc tgcacccagc
     7621 aacttcccaa tcccaagtct tcggcctgaa gctgaatcat aatagaggca atggaagcgt
     7681 cctcaatcca tacattgctc gccaagggat cggcagtaac gacaatggcc aatgccgcgt
     7741 cggcaataaa ggccgaagcc tgctctttgc aatgtgaaag ttcactgagc aactttttat
     7801 catcgactgc aataaattgc cagctgttac tgcgctttga agtaggagcc atcagggccg
     7861 ctttcagcaa agcgactaca tcttcctgag aaagttcttc tccggtaaat ttccgcatgc
     7921 tgcggcgatt ttttattagt tcactgaaat tttccatgta tctatacttt gcattatttg
     7981 aatataccgc cagtcaccat agaatgcaca aacacacgcg aaccaaggta ccgcccggca
     8041 tgcccgtcta tataaggtat gccctgcagg actttgcatg aatcggcgcg ctccgtggcg
     8101 attcgagcgc aaagataggc aatttattcc actctcgtca actcgccggt cagtgaatcg
     8161 atgataaaac catgcacccg gacatctttc ggaataagcg gatggttctc tatggaacga
     8221 accgtgcccc tgacggactt caccggatcg tcgaatccgc ccagccacga attaaaatcg
     8281 accccgcagt agcgtatcat gtcgattgtt tcggacttga ttccccgctt tttcatgtga
     8341 gctatcattt cgtcgctgtt catgtggcaa gcaccgcaat cagaatgggc aatgaccatc
     8401 acttcttcta ctcccaactc gatgatagcc accagcagac tacggatgac actgccgaaa
     8461 ggatgggaaa tgacggcacc ggcattcttt ataatcttta cgtctccatt gtgaattcct
     8521 aaagcggcgg gcaacagttc tgtcaggcgg gtatccatac aggaaaggat ggcgattttc
     8581 ttatcaggat acttgttagt gatatacttt tcgtatcccc tgttctcaac gaactttttg
     8641 ttgaattcaa gaatttcttc taacataatc aaaaacggat tttattgtag tatctccaca
     8701 aagatagtca caaaacgaca gctcaacaaa ataagccctg caaatgttgt aaagagaaat
     8761 aaaaaatgta aatttgtccc gatatgccat taaaactgac tacatattac caaggaagtg
     8821 agattccgga ttttcccgga accaatacgt ttcattcgaa agagctattt cagatctacg
     8881 aagaaactcc gggctacacc ccacttctga ttatggcttc ggaagacgga aaacctgttg
     8941 cgcgactgct tgctgccatc cgcaaaagca tccgcatgtt tcctcccgct ttcatcaaac
     9001 gctgcgaaat ctatggcacg ggcgaatatc tgatagcgga agccgacaag gaaaggatat
     9061 tcggcgaaat gctggagcac ctcaccacgg aggctttgcg gaactcgttt ctaatagaat
     9121 tccgcaatct ggagaacgcc atgttcggct acaaatattt ccggtccaac agatacttcc
     9181 ctgtcaactg gctgcgggta cgaaactcgc ttcacggtat cgaaaacgcc gaacagcgtt
     9241 tcagcccctc ccgtatccgc cagatcaaaa aaggcctgaa aaacggagca aaagtagacg
     9301 aggcacgtac ggtagaagag atacgcgaat tttcgaatat gctgaggcat ctctattcgt
     9361 cccgcatccg taaacatttt cccaacatca tctttttcca acacatggac acccggctga
     9421 ttcacagccg gcaggcaaag attttcatcg tccgctacaa agacaaaatt atcggaggct
     9481 ctgcctgtat ctattcggga aacgatgcct atctctggtt ttcgggaggt atgcggaaga
     9541 cctatgcctt gcaatacccg ggtatactgg ctgtatggaa agccctccgg gatgcccatc
     9601 aaaacggatt ccgccacatg gagttcatgg acgtcggact cccatttaag aagcacggct
     9661 atcgtgactt cgtgctccgc ttcggtggca agcaaagcag cacccggcga tggttccgtt
     9721 tccgctggca atggctgaac gacctgctga tcaaaatata cgtctgaaca tccgcctgtc
     9781 tcagggatca gcgccaaccc tctccgcctt ttaaaccaac atcccttagg ttttaaacca
     9841 acgatgcctg ccttttaaac ccatgcacct taggttttaa acctattttc accataatta
     9901 attgcagaaa aatttcttta ttaaacaaga attgattttc tttgtgctgt tttataccat
     9961 tccgaaaaga cgattaatac caaaatttaa aaatatagtt atgaagattt cacacattga
    10021 acatttgggc attgccgtaa aaagtatcga agaagccctt ccgtattatg aaaacgtttt
    10081 aggtttgaaa tgctacaaca tcgaaactgt agaagatcaa aaagtaagaa cagccttcct
    10141 gaaagtaggt gataccaaaa tcgaattact ggaacccaca tgtccggaaa gtaccatcgc
    10201 gaaattcatc gaaaacaaag gtgcaggtgt tcatcacgta gcattcgcca ttgaagacgg
    10261 cgtagccaat gccctggccg aagccgaaag caaagagatc cgcctgatcg acaaagctcc
    10321 gcgcaaaggt gccgaaggcc tgaacattgc tttccttcac ccgaaatcaa ctctgggcgt
    10381 actgacagaa ctctgcgaac actaaaaaga tgtacgattc ggacgatccg cgccacggac
    10441 aaacggaatt tttctttgca ttaaattccc catccgggtt gtcaatcgtc cggttgtaaa
    10501 tattataacc ctttaaatta agaaaaactc atgagtaacc agcttgaaaa agtaaaagag
    10561 cttattgaac ttcgtgctca ggctcgttta ggtggtggcg aaaaggctat tgaaaaacaa
    10621 cacgccaaag gcaaatatac agcccgcgag cgtattgcac agttgcttga cgaaggtagt
    10681 ttcgaagaac tggatatgtt tgttcaacac agatgtacca atttcggaca agagaaaaaa
    10741 catttcctcg gcgacggtgt ggtaaccggt tatggaacga tagaaggtag attagtatat
    10801 gttttcgcac aagatttcac agtattcggt ggttcactgt cggaaaccat ggcacaaaag
    10861 atctgtaaag taatggatat ggccatgaag atgggtgccc ctgttatcgg tatcaacgac
    10921 tcgggtggcg cacgtattca ggaaggcatc aacgccctgt ccggttatgc tgaaatcttc
    10981 cagcgcaaca tcatggcttc gggtgtcatc ccacagattt caggtatttt cggtccgtgt
    11041 gccggcggtg cggtttactc tcccgccctg acagacttca cgctgatgac ggaaggtaca
    11101 tcttacatgt tcctcaccgg accggctgtt gtgaaaacag taacgggtga agacgtgtct
    11161 caggaagatc tgggtggtgc aagcgtacat gccagcaagt ccggtgtaac tcacttcact
    11221 gccgaaaccg gtgaagaagg tttggcgatt attcgcaagc ttctcagctt tattccgcaa
    11281 aacaacctgg aagaagctcc attggtgaac tgtaccgacc ccatcgaccg tatggacgac
    11341 ctgctgaacg agatcatccc cgacagcccg aacaaaccgt acgatatgta cgaagtgatc
    11401 ggcgccatca tcgataacgg agaattcctg gaagtacaga aagactatgc gaaaaatctt
    11461 attatcggtt ttgcccgtat gaacggacag tcggtaggtg tggttgccaa tcagcctaaa
    11521 tacctcgccg gagtactcga cagcaatgct tcacgcaaag gtgcacgctt cgttcgcttc
    11581 tgcgacgcat tcaacattcc actggtgaca ttggtagacg ttccaggatt ccttccgggt
    11641 acgggtcagg aatataatgg tgtaatcctg cacggagcca agttgctgta cgcttatggt
    11701 gaagccactg tgcccaaggt aactgttacc ctgcgtaaat cttacggtgg ttcgcacatc
    11761 gtaatgagtt gcaagcaact ccgcggcgac atgaactatg catggccgac agccgaaatc
    11821 gccgtaatgg gaggtgccgg tgcagtagcg gtattgtatg ccaaagaagc caaagatcag
    11881 gaaaaccctg ctcaattcct ggcagacaag gaagccgagt acactaaact gttcgccaac
    11941 ccgtacaatg cagccaaata cggttacatc gacgacgtta tcgaaccgag aaacactcgt
    12001 ttccgcgtga tccgcgccct gcaacagctg cagaccaaaa aattaaccaa ccctgctaaa
    12061 aagcacggta atattccatt gtaacaaatt aaacatcgat tgttatgaat aagaaaagaa
    12121 tcgggatatt tatcgctctg ctggcaatgg tttgcatggg gctcagggcg caaagtgcca
    12181 ccagtctgag aatcaatgag gttttggtcg tcaacgacca gaactatcag gatgactacg
    12241 gactgcacaa tgcgtggata gagatattca acacctcttt cgcttctgta aatctggaag
    12301 gttgctttct gacgaacgat aaaaacaatc cgaccaaata tcctattccc aaaggcgacg
    12361 tgctgactct gatcaagccg cgccaacatg ctttgttctg ggcagacgga atgcctaacc
    12421 ggggtacgtt ccacgtgaac tttacgctcg acccgaacaa agagaattac attgctttgt
    12481 atgactctaa cggtaaaact ctgattgacg aagtaaccat acccgccggt cagcttgccg
    12541 accgttcata cgctcgcgaa aaagacggaa gtgccaactg ggtagtaaaa ggtgaaggag
    12601 agcacagcta tgtcactccg agcaccaata atatgactat cgacaaaaac ccgaagatcg
    12661 agaacttcaa gaaacacgac tctatcggta tcggtatggc catcatcgcc atgtcggtcg
    12721 tattcatagg tttggtactc ttgtatcttt cattcaaggc ggtaggtaac gtagctgtca
    12781 gactgggtaa gaaaaacgcg atgaaagcca ccggtatcac tgacaagacg gaagcgaagg
    12841 aaaagaacct gggtagccac acaggtgaag aaaccgccgc aatcgccatg gctttgcatg
    12901 aatacctgaa tgacgctcac gacgttgaag acatgatttt gaccatcaac aaagtgaaac
    12961 gcacctactc accctggagt tcgaagatct acacactgcg tcagactccg aaaagataat
    13021 tactaaccct aataaaatga agcaatgaaa caatataaat ataaaatcaa cggcaacctt
    13081 tacaacgtta cagtgaacga tgtagaagat aacatagcca acgttgaagt gaacggaacc
    13141 tcttataaag tagagttgga caagcccgtc aaagccgctc cgaaaccggt gacccgtccg
    13201 gcagccgctc cgaaaacgga aacaggtgct ccggtagtaa ccaaacaacc gacagcttcc
    13261 aaaaaagacg gtgtgaaatc tccgcttccg ggcgttatcc tcgacataaa agtgaaagaa
    13321 ggggataccg tgaagagagg ccagacgatc atcatccttg aggctatgaa gatggaaaac
    13381 aacatcaatg ccaataaaga cggaaaagta gcagaaatta aagttaataa aggagattct
    13441 gtacttgaag gtacagacct cgtaatcatt gaataattat gggagatttc gtatcattct
    13501 tagggaataa ccttgttgac ttctggggat acaccggttt tgcgaacgcg acacccggac
    13561 atcttttcat gttgctaatc ggtctcttct ttatctacct tgccgtagcc aaagaatttg
    13621 aaccgatgct gctgatcccc attggcttcg gtattctgat cggtaatatt ccattcaata
    13681 tggaagccgg attaaaagtg ggtatttacg aagaaggttc ggtactgaac atcctttatc
    13741 aaggagtaac ctccggctgg tatccgccgc tcattttcct gggtatcgga gccatgacgg
    13801 acttctcggc gctgatctcc aaccccaaat tgatgctgat cggagctgcc gcgcaattcg
    13861 gtatcttcgg cgcgtatatc attgccctgc tcattgggtt cgaacccaac caggcgggtg
    13921 ctatcggtat cattggcggt gccgacggac cgacggccat cttcctttcg tccaaactgg
    13981 ctcccaacct gatgggtgcc atcgctgtgt cagcctattc ttacatggca ctggtgccgg
    14041 tgatacagcc acctatcatg cgtgcgctaa ccaccaaaca cgagcgtctg atccgcatga
    14101 aaccaccgag aatcgtatcg catacggaaa aagtaatctt ccccatcgtg ggtctgttgc
    14161 ttacatgctt cctggttcct tcgggtctgc ctttgctggg tatgctgttc ttcggtaatc
    14221 ttctgaaaga aagtggagta acccgtcgtt tggcaaatac ggccagtggt ccgttgatcg
    14281 atgtgatcac tatcctgttg ggactgactg tgggagcttc tacccaagct tcacaattcc
    14341 tcacctggga ttctatcttg atctttatcc tcggtgcatt ctctttcatc atcgcaacag
    14401 cgtcaggtgt catgtttgtc aaattcttca atctattctt gaagaaaggc aataagatca
    14461 atccgctgat tggtaatgca ggtgtatccg ccgtacccga ctcggcacgt atttcacagg
    14521 taatcggttt ggaatatgat ccgaccaact atctgctgat gcacgccatg ggtcctaacg
    14581 tagcgggggt tatcggttcg gctgtagctg ccggtatcct gctcggattc ctcatgtaaa
    14641 cgatattttt tcattagtaa ggtagacgtc cttcttttcg caaagaaggg cgtctttttt
    14701 ttgcgttaat ctatctaaaa gatattacga acctttcgta gaatggatat ttttactaac
    14761 ttgcggacaa taaaacaata cgtcctatga gaacaagaac aatgaaacca ctcttcctta
    14821 ttttctgtct ttgcctcagt cccctactga tgggccagaa tcaaaacaaa attcaggaag
    14881 caatggcaaa ctatgactac gagactgccg ttgaactgat aaacaaggaa cctcccacca
    14941 tcccactgtt aatgcagaaa gcaaaagccc tgaaaggaat cggcagcaat gcggaagctc
    15001 tacgttccat ccgccaagtg atagcggaag actccaccaa ccaacaggca cacatcgaag
    15061 cagcggaatg ctgtaaagca atggccaagt acaacgatgc gctggactac taccggaaag
    15121 ccatcagcct gaatcccaaa aacaagtatg cccgtttgca attcatcaac ctactttgca
    15181 acaccaaaaa ctatgctgaa gcttttggag aaagttcaat gatgtccgaa acggacagtt
    15241 cggccgtagt gctccaccta caggctcaaa gccttgaagg gatgcaacag atactaccgg
    15301 ctatcggttg ctatgaagtc attcaggata aatatccgga tgattatctg gctgcggcca
    15361 aactcggaaa cctgaacatt gtggctggat atcccgaata tgccatccaa gctaccgaac
    15421 gctataggga acgggactcc accaacctga ttgtcaacca gcaaaacgct ctcgcctact
    15481 gccacgccga acaatatccg acagccatca agcgctatga aaagctgtgc caacaggggg
    15541 acagcagtac acagacctta tactacctgg gagtcagcta ttacgcggat gaatattatt
    15601 acgaagcgca cgcgtgtttc agcaaactgc aaaaagagat ggaagaaaat cccaatctgc
    15661 tctattatct gggacgttgc tgcgccaaga cttcctggaa aaaagaaggc atcgaacacc
    15721 tggagaaagc tatcgaactg accattccca aagacagcac catgatccga ctttacaaag
    15781 gcttggtgga ttgttgtaaa ctggctcagg atactccaaa gcaaatccag gctctcagag
    15841 aactgtacaa atatgacaag acgaaccata aacttcttta tgacatcgcc tggaactatt
    15901 catatcaact caaagacaac aaatcggccg aacgttatct gcaggctttc ttaaaaaccc
    15961 gaaaggcgaa tgccaggaaa gaagaaccgg tgagtgagaa agggtaactt gtactcggac
    16021 ttgaaaatta ttacaacgct gccgaaaatt ggctgaaaga cttacagaaa gaaaagttct
    16081 tcaaagaagg aataccgtta gaaagtcaga aacaatagaa tctgtccccc ccatgaaaca
    16141 ttggatactc ctcctctatc tggggttcag cgtagtgctg caagcccaga acaccgcctc
    16201 cgttcaagaa gcaatggcaa actatgacta taaaacggtg atcagactga ttgatgaaga
    16261 aagtgcatca ccacagttac tcatacagaa agccaaagct ttaaaaggtt tagggcgtac
    16321 cgccgaagcc ctgtccactt tgcaacatat cattatcgag ctgcccgaaa atcagcaggc
    16381 attggtagag gcagcagaat gttgcaggca attgagcaaa tttaacgagg ccttggggta
    16441 ttatcggaag gtgatggaac tcaatcccga acatatttac gcacacttgc aatacacccg
    16501 cttgttatac aactatcagc gatacggcga tgcattgcgt gagagtatcg cattggccag
    16561 gaaagacagt tccgccaccg tattgcgact gatggcggaa agcatggaag gagccggcat
    16621 gccggtagaa agtatgtttt gctatctttc catcatcagg aaatatccct ccgactatct
    16681 ctcggtagct aagctgggca gtatcttcaa tacaatgaaa gattacgaag gggcaattgc
    16741 cctgacagag gcataccgcc ggacggacag caccaatgta gaagtgaacc gtcaaaacgc
    16801 actggcgtat tgtctgcgca aagaatatcc caccgccatc aaacgttatc aggatctgac
    16861 cgcccgggga gacagcacac tgctgacatg ttattacctg ggagtcagct actacgctac
    16921 gaaagaatac tataaagcgc gcgattggct actcaaagca aaatcatgcc agtcacccgg
    16981 cgccaaccta ctctactatt tgggacgttc gtgctccaag acattatgga aacaagaggg
    17041 aataggatat ctgaaccagg ctatcgccct gactatcccc gccgacagta tcatggagcg
    17101 cttatactca ggcttggcag actgctacag gcaaaccaag caaacccggg accaaatcaa
    17161 ggctaccaaa gaacaataca aatatgcccc tgacaagcat attttacttt ataacttggc
    17221 gttcttatcg gacaaaatag gagatactaa agccacagag cattacttgc aggcttttct
    17281 gcgaacaaaa tccaaacaaa atgcagtact acagcagccg gatgatgacg aagaagaacc
    17341 cgcaccctac atagattact acaaaagtgc caccaataaa ttggaaagca tccgaaaaga
    17401 gaaattctta aagggagaaa agtgaattga tcggatagat gcatcgtttc ggacaattca
    17461 ccactgagtg cagacagagt ttcacagagg gagaataatg gaaaataaat ttgaagatgt
    17521 gcggtagaag gcacagtggc acgtaaccga agtcacatcg gcacgcagcc gaaattacgg
    17581 tgctgtgtag ctaaagttac ggtgctgcgt aatcaaagtt acggtgctgc gtagccgaag
    17641 ttacagtgct gcgtaatcaa agttacggtg ctgcgtagcc gaagttacgg tgctgcgtag
    17701 ccgaagttac ggtgctgcgt agccgaagtt acggtgctgc gtagccgaag ctatgacggc
    17761 atctcctttt ccggacgtca cgttcacctg attgcatcga aaagtgctcc ttatcggttg
    17821 agccccatcc cggagaattc tccaatgaaa acgtttgcat aaatagatgg cacacagtaa
    17881 gaaagaaaac ggaaaacaat ccgatgattt accctatatt agcaacatta aataataacg
    17941 agctaatatc atgaaaaaat tattgttact cttaggttca ttcctactgt cattaaccac
    18001 ttatgcagcc atgaacatat ccaaaatcga tccgcccttc tggttcaccg gtatgaacaa
    18061 tccggaactc cagttaatgg tatacggtga aggcatcggc caggcatccg tatcagtaaa
    18121 ttatcccggt gtatcgctca gcagcgtcgt gaaactggaa agcaacaatt acctgcttgt
    18181 ctacctacat ctcgataaag aagtaaagcc gggcaagatg cccatcacat ttacggtcgg
    18241 aaagaagaaa ttggtgaaag agtacgaatt gaaagcacgc agcaaagccg gagtcgatca
    18301 caaaggtttt gacgcatcgg atgcattata cctgctgatg ccggaccgtt ttgccaatgg
    18361 caatccggat aacgaccgga tagaaggcat ggccgaatat aaagtggacc gcaacgaccc
    18421 gaacgcacgt cacggaggcg acctggccgg tatcgaacaa aatctggact attttaccga
    18481 cttgggagtg accgcactct ggttcacccc ggtactcgaa aataatatga aaggcggctc
    18541 atatcacgga tatgcaacaa ccgattatta caaggtagac ccacgtttcg gcactaacga
    18601 ggaatatcgc tcactgatag cgaaagccca caaccggggc attaaggtcg tgatggacat
    18661 gatcttcaat cattgcggag tagaacatcc ctggatcaag gacatgcctt caaaggactg
    18721 gttcaaccat gcggacttca agaacaactt tgtgcaaact tcctacaagc tgactccaca
    18781 tgtagatccg tatgcctcgg agtacgattt cgaccagatg aacaacggct ggttcgtgga
    18841 agccatgcct gacctcaacc aaaagaaccc tcacgtatac aaatacctct tgcagaacag
    18901 cctgtggtgg attgagtacg ccgatatcga cggcatccgg atggacacct acccgtatgc
    18961 cgattacgat gccatgagca actggatgaa agaactgaac gaagaatacc ccaactacaa
    19021 cacggtgggc gaaacctggg ttaccgaacc ggcctataca gcctggtggc agaaagactc
    19081 caaactctcc gccccgcgca acagtcactt gaaaacagtc atggatttca gcttcttcga
    19141 caaagtcaac acggccaaga atgaacaaac ggacacttgg ttcaaaggat tggaccgtgt
    19201 ctacaacaat tttgtatacg attatctgta tcccaatccg gcttccgtac tggctttcat
    19261 cgagaatcat gacaccgacc gtttcctggg tgaaggcgaa aacctcgata tgctgaaaca
    19321 ggcctccacc cttttattga ccacccgacg catcccgcaa ctctattatg gaacggaggt
    19381 gatgatgaat ggagtaaaga gtaaaagcga cggctatgta cgaaaggact tcccgggcgg
    19441 atggacggac gataaagaga atgccctgac tcccgaggga cgtacccgat tgcagaatga
    19501 aagctataac ttctaccgca acctgctgaa ctggcgtaag ggcaacgatg tgatcgccaa
    19561 aggcagcatg aaacagttca tggtgcagca cggcgtatat gcttatgcac gccaatataa
    19621 agggaaaacg gtattcgtcc tgttgaacgg tacggataaa gaggtgaaac ttcccctgaa
    19681 atactatgcc gaagtgctga aagacaagac tcaaggaaaa gacgtcatta gcggaaaagt
    19741 aacggcactc aatgaagaac tgacaatggc accccgccaa tcgatggtta tagagcttta
    19801 atctcacacc ggttataacc gcataagcaa agggcacaaa ggatttcacc cgacatcctc
    19861 tgtgcccttt gtgtagccta atgcgaataa taatagtcaa acgtttgact attatcggag
    19921 aatattccta cctttgcagc gactaaaaga atacgacgat gacaaacaac gaatcggagc
    19981 gcgagctcgt cctacaaacc ttacgaacct ggatggcatt ccgccaggcc gttcagcggg
    20041 tactcaaacg ccacaacgtg gatatgacct tcgagatgct gcaagtaatg aactgcctgt
    20101 ggaacaaaca aggcatcagc cagcaatccc tggctgagaa aacagcaaag gacaaggctt
    20161 gcctgaccaa tctgattaat aatctggaaa agaaaaactg ggtgatacgg aaagaaggcc
    20221 cctccgaccg ccgaaaccgc ctgattttcc tgacgcccca aggcgaagaa cttgccctca
    20281 ccgtgaaacc cctgatcaac gatatctatg cccaaaccgg agcagagatg gaggcaagcc
    20341 ggataacgga atgcatcgaa gacctgaaga gactgcatga agtgctcaat gagatctaaa
    20401 agaaatccgc catgtccacc catcagataa agctaaaaca attgagaaga ctgaagttca
    20461 ggaacatctt tctcaacaca gtatgcatcc tgctggcatt ggcaggtatt tcatggacag
    20521 taaactactt ctggaaatac gcccgctacg agataaccaa tgatgccgta gtggatcaat
    20581 acatcgctcc gctaaacatc cggataccgg gctatatcaa agaagtacgt tttaccgaac
    20641 accagtatgt tcatgccggc gacacgttac tgatactgga cgaccgggaa taccggatcc
    20701 ggctgaaaga cgcggaagcg gccttgatgg atgccttggg atcaaaggaa gtgttaaact
    20761 ccggcatccg gacttcagga gtaaatgtag ccgtacaaga agccaacata gccgaaacac
    20821 tggcacgcct ttcacagcaa gaagcggaac tgaaccgata tacccggctc ctgaaaaagc
    20881 aggccgtcag ccaacaggat tatgaactgg ccaaagcgaa cttcgaagcg acccgggcaa
    20941 gatacaacgc cctgttgcga caaaaagaag cggcccaatc gcagtattcc gaaaccagca
    21001 aacgcagtac aggcgccgaa gccaatatcc tccggaagga ggccgacctg gagatggcca
    21061 aactaaacct gtcgtatacc gttgtcaccg caccctatga cggatacacg ggacgacgta
    21121 cacttgaacc gggacagttc gtacaaggcg gacaaactct ttcctacctg gtacggggca
    21181 atgacaagtg ggtgacagcc aattataaag agacacaaat agcccatatc tatatcgggc
    21241 aaaaagtccg catcaaagta gatgctttca gcggacgcac ttttcacggg accgtaaccg
    21301 ccatttccga agccaccgga tcgaaatact ccctggtacc gaccgacaat tcggcaggga
    21361 acttcgtcaa agtgcagcaa cgcattccgg tccgcatcga tctcaatgac gcctcacccg
    21421 aagagatgga atgtctccgt gcagggatga tggtagaaac ggaagcggtc cgcccttagg
    21481 cttatggtga agctcaatct gcctacccgt ccctgggtgc ctcaatggtt gggcatcgtg
    21541 accatgttta ttgtcatctt tcccatcacc ctgctcaacg gtgcctacac aggaagtatg
    21601 gtcgaagtat cgaacacgct gggagtattg agcgaagata ttaccatggc ttactattca
    21661 gcttcggtag ggatggctgt tgcctatccc atcgtaccga aaatacgcac catagccact
    21721 ccgaaaacct tactgcttac cgacctgctg ctacagatat tcttcagcct ggtatgcgcc
    21781 caaaccggta gtatggacgt catcatggta tgcagtttct gtatgggatt tctcaaagcc
    21841 ttcgtcatgt tggagttcat catcctgatc cgcccgctct tcagtccgaa aaacgtacga
    21901 agtgaattct atgcctactt ctaccccatc gttttctccg gaggtcagct atcgatggct
    21961 atcaccgctc aactggccta tcactaccaa tggcagcaca tgtactattt tgtcaccatc
    22021 ctcttgctga tcgccattct gttcgtcatc tgtttcttcc gctatgcaag gcgtcccatg
    22081 cacattccgt tcaaagaaat ggacggaaga agcatgttca tcatcgccac cgctttcctg
    22141 ctaacgctct atacatttac ctacgggaaa acactcgatt ggttcgcatc cccgaagatc
    22201 agagtatatg tattcgtcat cccgctcctg atagttctct tcatccatcg gcagcgtaca
    22261 caaggcaaac cctttgtcag cctgaaacca ctctttctgc ataaatccat catcggatat
    22321 ggcttcatgg tactcgccat gttcctgaca gccaccagtt cactggtaac caactatatg
    22381 aacagcatca tccgggtaga cagcatacac gccaattcgc tgagcctgtg gctattgccc
    22441 ggatatgtgg taggagccgt catttgcttc tggtggttcc gatggcaacg atggaggttt
    22501 cgcttcctca tttcaggagg tatgttctgc tacgtcatct atctggctat cctctacttt
    22561 ggtatcaccc cttatggaac ttatgaaatg ctctacctcc ccatcctgtt ccggggagtg
    22621 gggatgatgg tcatattcat tgcgttcggt gtgtttgttg tcgaagattt agacccgcgc
    22681 ctgacgttgt ccaatgcctt cttcctgatt tcattccgct cagtattggc tccggtcctg
    22741 tccgcttcgt tctttaacaa catgctttac tatctgcagg caaaggggat gaacattctt
    22801 tcggaaaaca tgacgctgac caatccgctg gccgaacaaa aatacaatca ggcattgagc
    22861 aatgccctgg cgcaagggca cgaattcagc gaggccggac aattggcagc caacagtctg
    22921 tactccactt tgcagcagca atccctgctg cttgccctga aaaccctaat cggctatgta
    22981 ctgatactgg cactggtgat tgctgtcatc gcagcgttca ttcctttcca taaaacgctg
    23041 aaggtggctg tagtgaagac gggtgacgat atggtataat gagaagggat acaaaaaagc
    23101 cacccaattg cttgagtggc ttcttaaaat ataaattaaa tcaagtaaaa cttttaaata
    23161 ctagatttgg aatttattca gctaacttgt tgtcagaacc cagcacgttg ataattttgt
    23221 gcttgtagag tttttccata ttgtcgcgag ccggtcccag atatttacgc gggtcgaact
    23281 cagccggttt ttctgcgaat accttacgga tagcagcagt catagccagg cgagagtctg
    23341 agtcgatgtt gattttgcaa acagcagact tagcggcttt acgcagttcc tcttcaggaa
    23401 taccgatagc agctttcagt gcaccaccaa actggttgat agttgcaacc tcttcttcag
    23461 gaactgaaga tgatccgtga agaacgatag ggaatcccgg aagttctttc attacaccgt
    23521 ccaatacgtc gaatgccaac ggaggaggaa ccatacggcc tgtcttcgga tcgatgtggc
    23581 actgttccgg agtaaatttg taagcaccgt gagaagtacc gatagagata gccaatgaat
    23641 cgcaacctgt cttggtaacg aaatcaacta cttcgtccgg ttcagtatat gtgtggtggt
    23701 cagaagaaac ttcgtcttct acacctgcca atacgccaag ttcaccttct acagttacat
    23761 cgaactggtg agcgtattca acaactttct tagtcagagc aacgttttcg tcgtaaggaa
    23821 ggtgagaacc gtcgatcatt acagaagaga agcctgagtc gatacagctt ttgcaagttt
    23881 cgaaagtatc tccgtggtcg aggtgcaaaa cgatttcagg atttttgcag ccgagttctt
    23941 ttgcatattc tacagcaccc tgagccatgt aacgcaacaa tgtagcgtta gcatactgac
    24001 gagcaccttt tgatacctgc aaaataaccg gagacttagt ttctacagca gccttgatga
    24061 tagcctgcat ctgttccata ttgttgaagt tgaatgcagg gattgcatat ccacccttga
    24121 tagccttagc aaacatatct ctagtgttta ccagacctaa atctttgtaa ttaaccattt
    24181 tgtttaaaag tttattgtta gtgaattaaa aattctatgc aaaagtaaga ataatccttt
    24241 gaatagagaa accctcgggc ggaaatatcc gtttgaggag cgtaattcaa ttctatttca
    24301 aattatttcc catcctttaa gagctgtttg taatgtctac gtagcaaata aaggtttttt
    24361 attgtttcct catatatata atggtaggca aatgatcgct gtaaccatcc aaccacactc
    24421 tgccaccata tgtacgcagg ggtgcaccct tatatttacc atcctgctga aacaggtaat
    24481 cgcgcatgaa aacttcattg tgatcatatt tcaatccttt tgttgcttga agcagcgtgg
    24541 gtgaaaggat gatctgatcg aacagattcc atttgcctcg atagagcaaa gtgcccactc
    24601 ccttatcttc cagcgtcacc caccaggggt tgtaaaggt
//
