LOCUS       c00045_gnlPro..        15929 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|BFFJEIOL_45.
ACCESSION   c00045_gnlPro..
VERSION     c00045_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-04 01:24:23
            Original ID  :: gnl|Prokka|BFFJEIOL_45
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 8213
            Orig. end    :: 24142
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..15929
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[18213:23717]"
                     /cutoff="10000"
                     /detection_rule="(TPP_enzyme_C and not (PFL-like or
                     PFL_6_pcresol or PFL_9_tma or Gly_radical or Gly_430_pcre
                     or Gly_8-9_TMA or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and
                     minimum(2, [ALS_ss_C, AlaDh_PNT_C, Arginase, BKACE,
                     BcrAD_BadFG, Beta_elim_lyase, CPSase_L_D2, Cys_Met_Meta_PP,
                     ELFV_dehydrog, GRDB, Glu_syn_central, Glu_synthase,
                     Gly_reductase, HAAA1, HG2B1, HG2B2, HGD-D, HleuD1, HleuD2,
                     HleuS1, HleuS2, Homoserine_dh, ILVD_EDD, IlvC,
                     Lactoyl-CoA1, Lactoyl-CoA2, Lyase_aromatic, MAAL_C,
                     OKR_DC_1_5_lysine, OKR_DC_1_5_ornithine,
                     OKR_DC_1_7_arginine, OKR_DC_1_C, OTCace, PALP,
                     Proline_reductase, Sacchrp_dh_C, TPL, Thr_dehydrat_C, TnaA,
                     Urocanase]) and not (POR or POR_N or PFOR_II))"
                     /neighbourhood="10000"
                     /product="TPP_AA_metabolism"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      10001..15504
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(TPP_enzyme_C and not (PFL-like or
                     PFL_6_pcresol or PFL_9_tma or Gly_radical or Gly_430_pcre
                     or Gly_8-9_TMA or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and
                     minimum(2, [ALS_ss_C, AlaDh_PNT_C, Arginase, BKACE,
                     BcrAD_BadFG, Beta_elim_lyase, CPSase_L_D2, Cys_Met_Meta_PP,
                     ELFV_dehydrog, GRDB, Glu_syn_central, Glu_synthase,
                     Gly_reductase, HAAA1, HG2B1, HG2B2, HGD-D, HleuD1, HleuD2,
                     HleuS1, HleuS2, Homoserine_dh, ILVD_EDD, IlvC,
                     Lactoyl-CoA1, Lactoyl-CoA2, Lyase_aromatic, MAAL_C,
                     OKR_DC_1_5_lysine, OKR_DC_1_5_ornithine,
                     OKR_DC_1_7_arginine, OKR_DC_1_C, OTCace, PALP,
                     Proline_reductase, Sacchrp_dh_C, TPL, Thr_dehydrat_C, TnaA,
                     Urocanase]) and not (POR or POR_N or PFOR_II))"
                     /neighbourhood="10000"
                     /product="TPP_AA_metabolism"
                     /protocluster_number="1"
     cand_cluster    1..15929
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(TPP_enzyme_C and not (PFL-like or
                     PFL_6_pcresol or PFL_9_tma or Gly_radical or Gly_430_pcre
                     or Gly_8-9_TMA or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and
                     minimum(2, [ALS_ss_C, AlaDh_PNT_C, Arginase, BKACE,
                     BcrAD_BadFG, Beta_elim_lyase, CPSase_L_D2, Cys_Met_Meta_PP,
                     ELFV_dehydrog, GRDB, Glu_syn_central, Glu_synthase,
                     Gly_reductase, HAAA1, HG2B1, HG2B2, HGD-D, HleuD1, HleuD2,
                     HleuS1, HleuS2, Homoserine_dh, ILVD_EDD, IlvC,
                     Lactoyl-CoA1, Lactoyl-CoA2, Lyase_aromatic, MAAL_C,
                     OKR_DC_1_5_lysine, OKR_DC_1_5_ornithine,
                     OKR_DC_1_7_arginine, OKR_DC_1_C, OTCace, PALP,
                     Proline_reductase, Sacchrp_dh_C, TPL, Thr_dehydrat_C, TnaA,
                     Urocanase]) and not (POR or POR_N or PFOR_II))"
                     /kind="single"
                     /product="TPP_AA_metabolism"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..15929
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="TPP_AA_metabolism"
                     /region_number="1"
                     /rules="(TPP_enzyme_C and not (PFL-like or PFL_6_pcresol or
                     PFL_9_tma or Gly_radical or Gly_430_pcre or Gly_8-9_TMA or
                     PFL_acetate1 or PFL_acetate2 or Gly_radical_scatole or
                     PFL_proline or PFL_toluene) and minimum(2, [ALS_ss_C,
                     AlaDh_PNT_C, Arginase, BKACE, BcrAD_BadFG, Beta_elim_lyase,
                     CPSase_L_D2, Cys_Met_Meta_PP, ELFV_dehydrog, GRDB,
                     Glu_syn_central, Glu_synthase, Gly_reductase, HAAA1, HG2B1,
                     HG2B2, HGD-D, HleuD1, HleuD2, HleuS1, HleuS2,
                     Homoserine_dh, ILVD_EDD, IlvC, Lactoyl-CoA1, Lactoyl-CoA2,
                     Lyase_aromatic, MAAL_C, OKR_DC_1_5_lysine,
                     OKR_DC_1_5_ornithine, OKR_DC_1_7_arginine, OKR_DC_1_C,
                     OTCace, PALP, Proline_reductase, Sacchrp_dh_C, TPL,
                     Thr_dehydrat_C, TnaA, Urocanase]) and not (POR or POR_N or
                     PFOR_II))"
                     /tool="gutsmash"
     CDS             1453..2121
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) SDH_beta"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg45_10"
                     /sec_met_domain="SDH_beta (E-value: 1.3e-14, bitscore:
                     45.4, seeds: 368, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSFISAFDVMGPNMIGPSSSHTAGAARISYLARKMIEGPLKRADF
                     ILYGSFARTYRGHGTDRALLGGIMGFSTDDMRIRNSFNIAHEKGLEFSFTPNELETDIH
                     PNTVDICMENEKGQKMTVRGESLGGGKVRIVEINHVQVDFTGEYSAVIVIHQDTPGVVA
                     YITKCLSDRNINIAFMRLFREGKGDIAYTIVESDGKLPENIVPAIRENPNIHEVMIVQM
                     "
     CDS             2141..3010
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) SDH_alpha"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg45_11"
                     /sec_met_domain="SDH_alpha (E-value: 6.5e-75, bitscore:
                     242.5, seeds: 645, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDFKNANELLALCEEKNLPVSEIMRIREIELGETVSEIVNKKMTR
                     VLEIMKDAAFSPIRQPIKSMGGLIGGEARKLSLHAQEKRGLCGELLQKAVTYAMATLET
                     NASMGLIVASPTAGSAGIVPGLLLAMQEHYHFSDKKIIQVLFNASAIGYLAMRNATVAG
                     AVGGCQAEVGVASAMAASAAVELMGGTPKECTFAASTVLMNMLGLVCDPVGGLVEYPCQ
                     NRNAAGVANALIAAEMALAGIPQLISLDEMIQTMFTVGKKIPAELRETAMGGCAVTQSA
                     CEACHICR"
     CDS             complement(3213..3842)
                     /locus_tag="ctg45_12"
                     /transl_table=11
                     /translation="MSEWIRKINWKYVIVMLIGNVILGLGIAIFKLSGLGNDPFSGMVM
                     ALSDRIGIDYPIFLIIINMIIFVVEIIFGRKMIGLGTFVNALLLGYVVSFFYNIILCIE
                     PTQMIQRILTVCVGVVVTSLGVSMYQLSRQGVAPYDSISLIMTERFPKISYFWHRISND
                     ALCALICWLAGGIVGLGTLVSAFGLGPVVQFFDTYFTSKLLEKLGE"
     CDS             4086..5177
                     /locus_tag="ctg45_13"
                     /transl_table=11
                     /translation="MKKLKAFLRRKDIEISIKRYGIDALGAMAQGLFCSLLIGTIINTL
                     GTQFHISFLTTAVATVNDTQYTVGSLASAMSGPAMAVAIGYALHCPPLVLFSLITVGFA
                     SNALGGAGGPLAVLFVAIFASEIGKAVSKETKIDILVTPLVTIGVGIALSAWWAPALGS
                     AAMKVGNIIMWATNLQPFLMGILVSVFVGIALTLPISSAAICAALGLTGLAGGAAVAGC
                     CAQMVGFAVMSFRENKWGGLVSQGIGTSMLQMGNIVKNPRIWIAPILTSAITGPLATCL
                     FKLQMNGTPVSSGMGTCGFVGQIGVYTGWMNDIAAGTKTAVTGWDWAGLLLISFILPAI
                     LCPLINMFIRKLGWVKDGDMTLS"
     CDS             complement(5373..6029)
                     /locus_tag="ctg45_14"
                     /transl_table=11
                     /translation="MAKKKIYAVRKGHKTGLFATWAECQKAVSGYSGAEFRGFTEKEEA
                     LAFLNMETAGNVSGDKEKEAAGIVEVPENMVIAYVDGSFEKNIGRYAFGCVILTPDGQE
                     IRKSGSGSDPAGVAIRNVAGEMLGSMTAVNWAIENKYPAVEIRYDYEGVEKWVTGVWRA
                     KTPLTSKYAAHMQEAGKKVGISFCKIAAHTGKHYNEEADQLAKSALLKMDEEVRI"
     CDS             complement(6310..7494)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fe-ADH"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1035:Iron-containing alcohol dehydrogenase (Score:
                     374.1; E-value: 2e-114)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg45_15"
                     /sec_met_domain="Fe-ADH (E-value: 6.9e-115, bitscore:
                     374.1, seeds: 219, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNPFEFFIPQNITVGAGTLAKLPECAKKLGGSHAMLISGPTLRKM
                     GVVDKAADYLKDAGMAVDIFTDVEANPSVTTVEKATEAYKESGADFIVALGGGSPMDVA
                     KAVGVTAQYGGSITEYEGAHKVPGKIVPLIAIPTTAGTGSEVTAFSVITDHSRDYKLTV
                     FSYELLPAYAILDPELLTSAPASVAAACGIDAFIHAEEAYVSTAASPFSDAMAEKAMEL
                     IGGNIRRFVARRTDLEAAEAMLTGSLFAGIAFSFARLGNVHAMSHPVSAFFNVAHGVAN
                     AVLLPVIAEYNALADHGRYLKIYNYISPIPAYEDEFEPLMLVDAIRELNEDIGIPEDLT
                     TAIRQAKKGEEISGEEIESKIDAMADDAMKSGNIAVNPRSSRKQDIVELYHKAL"
     CDS             complement(7631..9151)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) AA_permease_2"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg45_16"
                     /sec_met_domain="AA_permease_2 (E-value: 3.7e-47, bitscore:
                     151.5, seeds: 50, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MEQKTSEFDKVLGAWDILVIAFGAMIGWGWVVSSGNWIESGGVLG
                     AAIAFVIGGIMIFFVGLTYAELTAAMPQCGGEHVFSYRAMGSTGSFICTWAIILGYVSV
                     ACFEACAFPTIITYLWPGFLKGYLYTVAGFDVYASWLIVAIVIAFLIMIININGAKTAA
                     VLQTVLTCIIGGAGIILIVASVVTGSVDNLQGQMFVGNGTGEAMKNIIKVAVITPFFFI
                     GFDVIPQAAEEINVPLKKIGKMMILSVVLAVVFYSLVILAVGYILNPAEIVESQQGTGL
                     VTADAMAKAFGTKVMAKVIIVGGMCGIITSWNSFLLGGSRAMYSMAESYMIPPFFAKLH
                     PKHKTPVNSLYLIGALTMLAPFAGRTMMVWICDAGNFGCCLAYCMVSVSFLILRKKEPD
                     MARPYKVGHYKFVGFMAVVMSGLMLLVYCIPGSGGSLVFQEWIMVGGWSLLGVVFYAIC
                     KRKYKEDFGKLIELISDEDAASLMPEADDEELDVVIDAAIDRVLSSMA"
     CDS             complement(9155..9796)
                     /locus_tag="ctg45_17"
                     /transl_table=11
                     /translation="LSVRGKSMKHLVITIGCEYGAKGNAIGKKIAQDLGIKFYDRDLVD
                     EIIKEVGIPTDIMDRVEEGGTIAGKGAQGDVRGSFSKYADLTDRAIHVQKQIIRKLAQK
                     EACVIIGRSADYILKDTEGIRLVRAFIYAPNDVRVHNIMESHNLSEKDAKLLLDEKDKR
                     YHKRHLALTGSNRGDRHNRDILINSDFLGIQGTAEYLEDLIAKKYGKKEV"
     CDS             complement(10001..11218)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: Beta_elim_lyase"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Aminotran_3"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg45_18"
                     /sec_met_domain="Beta_elim_lyase (E-value: 2.4e-08,
                     bitscore: 24.0, seeds: 43, tool: rule-based-clusters)"
                     /sec_met_domain="Aminotran_3 (E-value: 2.2e-110, bitscore:
                     359.5, seeds: 14, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKLKDTGLTFQDIKDKVNKYMIETYERFDFLAETAEGMYIYDENK
                     TPYLDFYAGIAVNSAGNCNPKVVAAAKDQLDDIMHTFNYPYTIPQALLAEKVCETIGMD
                     KIFYQNSGTEANEAMIKMARKYGIEKYGPNRYHIVTAKMGFHGRTFGAMSATGQPGNGC
                     QVGFGPMTYGFSYAPYNDLQAFKDACTENTIAIMVEPVQGEGGVHPATMEFMQGLRKFC
                     DENDMLLLIDEVQTGWCRTGAVMSYMNYGIKPDIVSMAKALGGGMPIGAICATAEVAKA
                     FTTGSHGTTFGGHPVSCAAALAEVNELLDRDLAGNAKKVGDYFAAKLEKIPHVKEVRHQ
                     GLLVGVEFDDTIGGVDVKHGCLDRHLLITAIGAHIIRMIPPLIVTEEECDKAVAIIEDT
                     IKSLEK"
     CDS             complement(11737..12291)
                     /locus_tag="ctg45_19"
                     /transl_table=11
                     /translation="MDYLSNNVAVNLKRIRKSKSMSLDQVSEQTGVSKSMLAQIERGTA
                     NPSLGVLGKITSGLRIEFQELIQPPRVDCCLVTPAELVPTKEVAGQYRVWTCLPYEDTR
                     LVEVYRIEVEPDGVYISGSHGEKTREYLAVMEGVLTVECHGEKYEIHRDQVFKFETDQE
                     HVYRNTGKEKACCTCFFLDYH"
     CDS             13259..14977
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: TPP_enzyme_C"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg45_20"
                     /sec_met_domain="TPP_enzyme_C (E-value: 9.8e-49, bitscore:
                     155.5, seeds: 323, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKQISGNKLLVKALKEEGVEYLFGYPGACTIDISDELYKQDDVKI
                     ILPRHEQALVHEADAYARTTGKVGVCLVTSGPGATNLVTGLATANYDSVPLVCFTGQVA
                     RHLIGNDAFQEVDIVGITRSITKYGVTVRRREDLGRIIKEAFYIARTGRPGPVLIDLPK
                     DVMAELGSAEYPKNVNIRGYKPNTDVHIGQLKRAIKLLNKAKRPLFLAGGGVVISRAHE
                     IFREVVEKTKVPVVTTVMGKGSIPTDHPLYIGNLGMHGAYAANMAVSNCDVLFSIGTRF
                     NDRITGKLHEFAPHAQIIHIDIDTASISRNIQVDIPIVADAKEAITKMNEYVQECSTDK
                     WLNLIKNWKEEHPLKMRPNDLLSPMDILKEINEQFENSIIVTDVGQHQMLVSQYAEITE
                     GKQMIMSGGLGTMGYGLPGGIGAKIGNPDRPVIVISGDGGVQMNIQELATAVLEELPVI
                     LCIFNNEYLGMVRQWQKLFYGKRYAMTNLRAGALSRRTEGMEYPQYTPDFIRLAESYRA
                     KGIRVTKKEEIAAAFEEAKKNTKAPTVIEFIIDPEEMVYPMIKPGGTLEDMIMDC"
     CDS             14995..15504
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: ALS_ss_C"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg45_21"
                     /sec_met_domain="ALS_ss_C (E-value: 9.1e-23, bitscore:
                     70.9, seeds: 685, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDKGMKKRWISLYVENQVGVLSKISGLFSGKSYNLDSLTVGTTED
                     PTVSRMTIATVSDDETFEQIKKQLNRMIEVIKVIDFTDVFVRMKEILYIKVFNCSKEDK
                     VELFQIAETFKAKVIDYGKDSLLLEFVQTATKNDAVVKLIKEEFHRIEVVRGGSVGIES
                     ISMMER"
ORIGIN
        1 tagctccgta aaacttctgc tgctctgtca ctacaaaaat cgtagaaata ttatcattct
       61 ttgcagcctg ttggatcaga ctgttcatcg cctgctttac tgtcagctta tctgtgatca
      121 caatataatt tgttgtcatg cggcttccga tctcatcctc atcaaaggat gcgatcatct
      181 ccacatcacg tcgaacttca ggttccagca gatcgatcag tatttttttc tttgtttttt
      241 caactttatt taatacatct gcaagagcat ctgtctccat tctggataaa atggctgctg
      301 cttttttcac atccatttca ttcagatact ctgctgcatt ctcctcatct gtatattcaa
      361 aaatatcaga gagcatatct gtatccagga tacggtacag cttgcaccgc tcctgtacag
      421 tcagtttcgg cattacatct gccaggtcat tctcatgata atcctgcagc cttcctgcca
      481 taacggccgg agatgtgttg ctgcggatga tcttcagaat ttcttttgaa taatcctgta
      541 ctcttttatc cattctttca tcctccgttt tttttgcata aaagcacacc aaaagaaagc
      601 agtttgtcat ttattacatt ttactgccat ttcttccacg ctttttccag cacaataaac
      661 tgcaggatat caaaccataa cctgctgttt atccgctgtc cgtaactgtc cggcatcttc
      721 gccggatcat taccgcttaa atatgtaatt gcatgattcg gggaaatttc ataaatacag
      781 gataagaaat gaaaaagaca tccgatcttc cacatacaga aactgtcaga tcacagacag
      841 taaaaaatct ctattctata tgcatacatg gaaaatcctg aaaatatatg actacagcag
      901 aacaaaaacg gctgccgtac tcatatactc tttttatttc agatcctgtg ctactacttc
      961 gcccatgaga atcgcaatta tccattctgt tccacctgcc ttttttatat ttttaattca
     1021 gatattctgc acatttcgga agtacttccc aaatgcactg ttattgtaac cgccacccgg
     1081 ccaaaaagca accctgtttt agtatttttt acattaattt ttgttaatat taacgaaacg
     1141 atagattttt actgttcact ccgtttccgg caacatgctt agcggaatat taccgttaaa
     1201 cagtaacgat acatttgctt cttttacaga cagatgttac aatatattcg gtaatttgca
     1261 catactatag cattatgcat ttaagacagt tcagcagagt gcgaaagaca aggaagatag
     1321 ctgcaggcgt tgacgtacgg taaagatatc tgacgcagga tttcacactc tgatgggctg
     1381 gattaagatg cattatttac caggaatgct atataacaat cgtcactatt ttactacagg
     1441 agaatatttt atatgtcatt tatcagtgca tttgatgtaa tgggaccaaa tatgatcggt
     1501 ccttccagct cacataccgc aggcgcggca cgaatttcct atctcgcccg gaaaatgatc
     1561 gaaggtccat taaaaagggc tgactttatt ctgtatggtt cctttgccag aacttaccgg
     1621 ggacatggta cagacagagc actgcttgga ggtatcatgg gattttccac agatgatatg
     1681 cggattcgaa attcttttaa tattgctcat gagaaagggc tggagttctc attcactccg
     1741 aatgaactgg aaacagatat ccatccgaac actgtagaca tctgcatgga aaatgaaaaa
     1801 ggacagaaaa tgaccgtccg cggcgaatcc cttggaggcg gcaaggtccg tattgtggaa
     1861 atcaatcacg tacaggtaga ctttacaggc gaatacagtg cagtgatcgt aattcaccag
     1921 gacactcccg gcgttgtggc ctatattacc aaatgtctga gtgaccgcaa tatcaatatt
     1981 gcatttatgc gtctgtttcg tgaaggcaag ggggatattg cttatacaat cgtagaatct
     2041 gacggtaaac ttcctgagaa tatcgttcct gcgatccgtg agaacccgaa tattcatgaa
     2101 gttatgatcg tacagatgta aagaaaggag gatttttatc atggatttta aaaatgcaaa
     2161 tgaactctta gctctctgtg aagaaaaaaa tcttcctgtc tcagagatta tgcgtatccg
     2221 tgagattgag cttggcgaaa cagtctctga aattgtaaat aaaaaaatga cacgggtact
     2281 ggagattatg aaagatgctg ctttctcgcc aatcagacag ccgataaaat ctatgggcgg
     2341 tctgatcggt ggagaagcca gaaagctgag tctgcacgct caggagaaaa gagggctctg
     2401 cggtgagctg cttcaaaaag cggtcaccta tgccatggca actctggaaa ccaatgcatc
     2461 catgggactg atcgtagcct ctcctactgc cggttctgcc ggaatcgtac ctggactgct
     2521 gcttgcaatg caggaacatt accatttctc tgataaaaaa attattcagg tattatttaa
     2581 tgcaagtgcc atcggatatc tggcaatgag aaacgccaca gttgcaggtg ctgtgggtgg
     2641 atgtcaggct gaggtgggag ttgcttctgc catggctgcc tctgctgctg tagaacttat
     2701 gggcggtacc ccaaaagaat gtacattcgc agcatctact gtacttatga atatgctggg
     2761 cctggtatgt gatccggtag gtggtctggt ggaatatccc tgccagaacc gaaacgccgc
     2821 cggtgtagct aacgcactca tcgccgcaga gatggccctc gcaggtatcc cacagctcat
     2881 ctccctggat gaaatgatac agacaatgtt tacagtcggc aaaaaaatcc ctgctgaact
     2941 gcgtgaaacc gcaatgggag gatgtgctgt cacgcagtct gcgtgtgagg catgtcatat
     3001 atgcagataa tccacagcac agtcaggcgt atattcgcaa tccgcttcgc tacgtggttc
     3061 tacaccgaat aactgctccg cagtttatca gaaggagctt gcactcctcc tgatacaaac
     3121 aagtccccac ccactgctta ttgcttttcg caacctccgc ggggacttgc ttgattcggt
     3181 taaggcatgg gaatgtttat caatattcct gattattctc ccagcttctc cagcaatttc
     3241 gatgtaaagt atgtatcaaa gaactgaact accggtccca gtccaaaggc actgaccagt
     3301 gttcccagtc ctacgattcc gcctgccagc cagcagatca gcgcacataa agcatcgttg
     3361 gagattctat gccagaaata ggaaatcttt ggaaatcttt ctgtcataat cagcgagata
     3421 ctgtcatatg gagctacacc ctgtctggat aactggtaca tggatactcc cagacttgtt
     3481 acaacaactc ccacacagac agtcagaatt ctctgaatca tctgagtcgg ttcgatacat
     3541 aaaataatat tataaaaaaa ggaaacaaca tatcccaaaa gcaaggcatt cacaaatgtt
     3601 cccagaccga tcatctttct tccgaaaata atctccacca caaatatgat catgttgata
     3661 atgatcagaa agattggata atcaattcct attctgtccg acaatgccat gaccattccg
     3721 ctgaaagggt catttccaag accggaaagt ttaaatattg caattcccag accaaggatc
     3781 acatttccaa tcagcattac gatcacatac ttccagttta tttttctgat ccattcactc
     3841 atctcttttt cctccgtata attgactttt tctatcatat cagacagtaa aatactttac
     3901 aatattcttt ctgcaaattg ttttccacta ttttatagca attccaccaa ataatgcaat
     3961 caggacagtt cagcagaata ccaaaaacta cttgctttac tccgtgaatg tgactataat
     4021 gagaaaaacg tatatgggtg tatatacacc cttctataca taataaaaac aggagaaagt
     4081 aatctatgaa aaagttaaaa gcatttctca gacgcaaaga catcgagatt tccataaaac
     4141 gttatgggat cgatgccctt ggtgccatgg cgcagggtct tttctgctcc ctgctgatcg
     4201 gcacgatcat caacacactt ggaacacagt ttcatatttc atttctgacc actgctgtgg
     4261 caactgtaaa cgacacacag tataccgtag gctctctggc atctgcaatg agcggtcctg
     4321 ccatggctgt tgccatcggc tatgcgctgc attgtccgcc gttggtgttg ttttcactga
     4381 tcactgttgg ctttgcatct aacgcattag gcggtgcagg cggaccgctg gctgtattat
     4441 ttgtagccat cttcgcttcc gaaattggaa aagcagtatc taaggaaacc aaaattgata
     4501 ttctggtcac tccacttgtc acgatcggtg taggtattgc cctgtccgca tggtgggctc
     4561 cggcacttgg aagtgcagca atgaaagtgg gaaatattat tatgtgggca accaacctgc
     4621 agccattcct gatgggaatc cttgtttctg tatttgtggg tattgcactg acacttccta
     4681 tctcatctgc cgcaatctgt gctgcgcttg gccttaccgg acttgccgga ggagctgctg
     4741 tagcaggctg ctgtgcacag atggtaggtt ttgcagtaat gtccttccgt gaaaataaat
     4801 ggggtggtct tgtttctcag ggaatcggaa catccatgct ccagatggga aatatcgtaa
     4861 aaaatccacg catctggatc gcaccgatcc ttacttctgc catcaccgga cctcttgcaa
     4921 cctgtctgtt caaacttcag atgaacggta ctccggtttc ttccggtatg ggtacctgcg
     4981 gttttgtagg acagattggt gtctacaccg gatggatgaa tgatatcgcc gcaggaacaa
     5041 aaacagcagt cacaggctgg gactgggccg ggcttttgct gatttccttt atcctgcctg
     5101 caatcctgtg tccgctcatc aacatgttta tccgtaagct tggatgggtg aaagacgggg
     5161 atatgacact ttcataagca aaaacagctg cgttaccagt caattgaaac tgttacttga
     5221 taaaaatttc agctaacagt ttcaatggta acacagctgc tttttatttt ttctacttcc
     5281 gtatattata ttgatttccc tgcggatcac tcaaattgtc atccacataa atttttcatc
     5341 cctttggaaa tcgcctttca gtgataagat ttttatattc gtacttcttc atccatttta
     5401 agcaatgcac tcttagccaa ctgatctgcc tcttcattgt agtgtttgcc tgtatgggct
     5461 gctattttac aaaaagaaat ccctactttc tttcctgctt cctgcatatg agcagcatat
     5521 ttgctggtca ggggtgtttt tgctctccat acacctgtca cccacttctc taccccttca
     5581 taatcatagc ggatttccac agccggatat ttgttttcta tagcccagtt gactgcagtc
     5641 atggaaccaa gcatctctcc tgccacattt cggattgcga ctcctgcagg gtcactgccg
     5701 ctgcctgatt tacggatttc ctgtccgtcc ggtgtaagga tcacacagcc aaatgcatat
     5761 ctgccaatgt ttttctcaaa gcttccgtcc acataggcaa tgaccatatt ttcaggtacc
     5821 tccacgattc ctgccgcttc tttttcttta tcaccggata catttcctgc tgtctccata
     5881 ttcagaaaag ccaatgcttc ctctttctct gtaaatcccc gaaactcagc tccggaatat
     5941 ccactcactg ccttctggca ctccgcccat gtagcaaaaa gtcctgtttt atgtcccttg
     6001 cgtactgcat atattttctt ctttgccata aaatcctcct gaacaatcaa tattttgact
     6061 cacattactt tactatattt tgattaatac tatataatct ttctttctat caggcaagtt
     6121 atacaatgga aatttctcaa aaaaacaacg tgcagataca ttttaaaatc gggataaatc
     6181 ttcaaacctg aagttatctg tcgacttcaa tgtttctgca cgttttttat aatagcagat
     6241 atttttaatc aataccttct gttaatctgt agcaattaca taaaatactg cattcctctt
     6301 tatctgaatt tataaagcct tatgatacaa ttccacaata tcctgcttcc tggaggatct
     6361 tgggtttact gcgatatttc cgctcttcat agcatcatcc gccatggcat caatcttgct
     6421 ttcaatctcc tcaccagaaa tctcttctcc cttctttgcc tgacggatgg ctgtggtcaa
     6481 atcttccggg attccgatat cttcgtttaa ttcccggatg gcatccacca gcatcagtgg
     6541 ttcgaattca tcctcatatg ccgggatcgg actgatataa ttataaatct tcagatatct
     6601 gccatgatct gccaacgcat tatattctgc gatcacggga agaagaactg catttgccac
     6661 tccatgtgcc acattaaaga aagcacttac cggatgactc attgcatgga catttccaag
     6721 ccttgcaaag gaaaaggcga ttcctgcaaa gagggagcct gtaagcattg cttctgcagc
     6781 ctccagatct gtacgtcttg ccacaaaacg gcggatattt ccaccaatca gctccattgc
     6841 tttctctgcc attgcgtcag agaatggaga tgctgctgtg gaaacataag cctcctctgc
     6901 atggataaat gcatcgattc cgcatgctgc tgccacagat gccggagcag aggtaagaag
     6961 ctcaggatcc aggatcgcat atgctggaag aagttcataa ctgaatacgg tcagcttata
     7021 atctctgctg tggtcagtga tgacagagaa tgccgtaacc tctgagccgg ttcccgctgt
     7081 agtcgggatt gcgatcagcg gaacaatttt tccgggaacc ttgtgagctc cctcatattc
     7141 tgtaatgctt ccgccatatt gggccgtaac tcccactgcc tttgccacat ccataggaga
     7201 accaccgccc agcgcaacga tgaaatctgc accggattcc ttataggctt ctgtcgcttt
     7261 ctctactgtg gtaacagatg ggtttgcttc cacatctgta aaaatatcca ctgccattcc
     7321 ggcgtctttc agataatctg ccgccttatc cacaactccc attttccgga gagttggtcc
     7381 ggagatcagc attgcatgag agcctccaag ctttttggca cattccggaa gctttgccag
     7441 agtacctgca ccgactgtaa tattctgagg aataaaaaat tcaaatggat tcattaattt
     7501 ctgcctcttt tcctgtattt tttcaataat tttttcaata ttgcaatgtg cagggcatct
     7561 accctgcaca aatttaaaac tctgttacca gaaataattc caagcaataa ttgtcatgtc
     7621 atttatagcg ttatgccata gatgaaagca ccctgtcaat agccgcatcg attaccacat
     7681 caagctcttc atcatcagcc tccggcataa gacttgctgc atcctcatca gagatcagct
     7741 caataagttt accaaagtct tctttatatt tacgcttaca gatcgcataa aatacaactc
     7801 caagtaagct ccagccgcct accataatcc attcctgaaa taccagactt ccaccggaac
     7861 ccggaataca gtagaccaga agcatcagcc ctgacatgac tactgccata aagcctacaa
     7921 atttgtaatg gcctactttg taaggtcttg ccatatccgg ttccttttta cgaaggatca
     7981 ggaaagagac agagaccata cagtatgcaa gacagcatcc gaagttacct gcatcacaga
     8041 tccagaccat cattgtcctt cctgcaaaag gagccagcat agtcagggca ccgatcagat
     8101 acagagaatt aaccggagtt ttgtgcttcg gatgaagctt tgcaaagaat ggaggaatca
     8161 tgtaggattc tgccatagag tacatggcac gtgaaccgcc aagcaggaag gagttccagg
     8221 atgtaataat accacacatt ccacctacaa tgataacctt ggccataacc tttgtcccga
     8281 aagccttggc catggcatct gctgttacaa gtcctgttcc ctgctgagac tcaacaatct
     8341 ctgccggatt caggatataa cctactgcaa gaatcaccag tgaataaaat acaacagcca
     8401 gcacaactga gaggatcatc attttaccga tttttttcag cggaacattg atttcctctg
     8461 ctgcctgtgg gataacgtca aaaccaataa agaaaaacgg agtgatgact gcaaccttaa
     8521 taatattttt cattgcttcg ccggtaccgt ttccaacaaa catctgtccc tgaagattat
     8581 ccacacttcc tgtaaccaca gaagccacga tcagaataat tccggcaccg ccgatgatac
     8641 aggtaagaac agtctgcaga actgccgcag tctttgctcc attaatgtta attatcataa
     8701 taagaaaagc aatcacgatc gccacgatca gccaggatgc ataaacatca aaacctgcaa
     8761 ctgtatagag atatcctttc aggaaccccg gccacagata agtgatgatc gtagggaaag
     8821 cacatgcctc aaagcaggca acacttacat atccaagaat gatcgcccag gtacagataa
     8881 aagaacccgt cgaacccatt gctctgtagc tgaatacatg ctcaccgcca cattgaggca
     8941 tggctgctgt aagctctgcg taagtcagac ctacgaagaa gatcatgatt ccaccgatta
     9001 caaatgcaat agctgcacca agcacaccac cggattcaat ccagttaccg gaggaaacta
     9061 cccagcccca accaatcatg gcgccaaatg caattacaag tatgtcccat gcaccaagta
     9121 ctttgtcaaa ttcagatgtt ttctgttcca taggtcagac ctcctttttc ccgtattttt
     9181 ttgcgatcag gtcttccaga tattctgctg ttccctggat tcccagaaaa tcactgttaa
     9241 taagaatatc cctgttatgt ctgtcaccac ggttacttcc tgtcagtgcc agatgtctct
     9301 tatgataacg tttatccttc tcatccagca gaagctttgc atccttttcc gaaagattat
     9361 ggctttccat aatgttgtgg acgcgaacat cgttaggtgc atagataaat gctctcacca
     9421 gccggattcc ttctgtatct ttcagaatat aatctgcaga ccgtccgatg atcacgcagg
     9481 cttctttctg agccagcttc cggataatct gcttctgtac atgaatggcg cggtctgtca
     9541 gatccgcata tttggaaaag gaacctctca catctccctg tgcaccttta cctgcgatgg
     9601 ttccgccttc ctctactctg tccataatgt ctgtagggat gcctacttct ttgatgattt
     9661 catctacaag atcacggtca tagaatttaa tgcccagatc ctgtgcgatc ttcttaccga
     9721 tggcattgcc cttggctcca tattcgcagc caatcgtaat taccagatgt ttcatgctct
     9781 tccctctcac actcaaattt ttgtcagatt ctcaaacttt cgagatccgc tgatttacta
     9841 tgcaaatcgc tactttctca tgtttggcag gtcccaggtt caaaagtctt atcgtgcagg
     9901 cacgaacgat tttttgaccc tgatatcata tcataaaagg gcgcacgaat ataattcgtg
     9961 acgcccttgt ccttttactg tatcactccg ctgccggatt ttatttttcc agtgatttaa
    10021 ttgtatcttc gatgatcgct acagctttat cacactcttc ttctgtaaca ataagaggtg
    10081 ggatcatacg aatgatatgc gctccgatgg ctgtgatcag aagatgtctg tcaagacagc
    10141 catgttttac atccactccg ccgatagtat cgtcaaattc cacacctacc agaagtccct
    10201 gatgtcttac ttcttttaca tgaggaatct tctcaagctt agctgcaaag tagtcgccca
    10261 ctttctttgc atttcctgcc agatctctgt ccagaagttc attcacctcg gccagtgcag
    10321 ctgcacagct taccgggtgt ccgccgaatg tagttccatg ggaacctgtt gtgaaagctt
    10381 tggcaacctc tgctgttgca cagatggcac cgattggcat tccaccgccc agagcctttg
    10441 ccatggatac gatatccggt ttgataccat aattcatata ggacataaca gcacctgttc
    10501 tgcaccatcc tgtctgtact tcatcgatca gaagaagcat atcattctca tcacagaatt
    10561 tacgaagtcc ctgcatgaat tccattgttg caggatgtac accaccctcg ccctgtacag
    10621 gctcaaccat aatggcaatt gtgttctctg tgcatgcatc cttgaaagcc tgaaggtcat
    10681 tatacggtgc ataggagaaa ccataagtca taggtccgaa tccaacctgg catccattac
    10741 caggctgacc tgttgcagac atggcaccaa aagttcttcc atggaatccc atctttgcag
    10801 ttacgatatg ataacggttt ggaccatatt tttcaatacc atatttacgg gccattttga
    10861 tcattgcctc gttagcctct gtacctgagt tctgatagaa aatcttgtcc attccgattg
    10921 tctcacagac cttctcagca agcagcgcct gcgggattgt gtatggatag ttgaatgtat
    10981 gcatgatatc atctaactga tcctttgcag cagctacaac cttcggatta cagtttcctg
    11041 cgctgtttac tgcaatacca gcgtaaaaat caagatatgg cgttttattc tcatcataaa
    11101 tgtacatgcc ctctgctgtc tctgcaagga aatcaaatct ctcataagtc tcgatcatgt
    11161 acttgtttac tttgtcctta atgtcctgaa aagttaatcc tgtgtctttt aatttcatag
    11221 ctgtgtcctc ctgcatcctt aagataaaaa aaaagcaaag acaaactgac ccgtatgggt
    11281 aagcgccttt gcttaacttt ttctgtgtat tattttgtac atccttacaa tatcactgac
    11341 cttatgattt gtcaacatgt ttttttgatc atttatattt ttttacagaa aactctgtgt
    11401 tctcattatt gtacatccaa tatttcctgc atattcgtgc gatattataa aggtttctca
    11461 acaattcata acaacacagc ctcttcatga aatagcagac tgacaaacca ttacatacat
    11521 cctttctttt cagatattca ttttcaagtg tatctttttc attattttgt gcattatatt
    11581 gtacatttca tactcatact tcggataaaa tcacctgctc cactacgcag tttcagacta
    11641 tggtaattcc agcaatcaca caggaaataa tcctgcaaac aggattctcc gcctgtggcg
    11701 ggttgcttca gcgacagaat ccctgataca actgtatcaa tgataatcca gaaagaaaca
    11761 ggtacagcag gctttctcct tccctgtgtt ccgatagaca tgctcctgat ccgtttcaaa
    11821 cttaaacacc tgatctctgt gtatttcata cttctcgcca tgacattcca cagtaagcac
    11881 accctccata acagccagat attctcttgt cttctcccca tggctgccac tgatataaac
    11941 accatccggt tccacctcga tccgatacac ctccaccaga cgtgtatcct cataaggcag
    12001 acaggtccat accctgtact gtcctgctac ctctttggtg ggaaccagct ctgccggtgt
    12061 caccagacaa cagtccactc tcggcggctg tatcaactcc tgaaactcta tcctcagacc
    12121 acttgtgatc tttcccagca cacccagaga aggattggca gtccctctct caatctgagc
    12181 cagcatactc ttactcaccc ccgtctgctc agacacctga tcaagactca tactcttgga
    12241 tttccggatt ctcttcagat tcaccgccac attgtttgat aaataatcca tatgtcccct
    12301 ccttgtcaag cggatattcg caatccgctt cgctacttgc tcataaccga ataactgctc
    12361 cgcagttcgg ttaaacaact gtattatttc ttttttatat cagcaatata aaaatatgtc
    12421 aattccatta ctgtttactc cgttctcagc aacgtattca aaattcattc cggaacacaa
    12481 attttatagc aattatccaa aacccggttg acaatttcct ctctataaat gtataatgta
    12541 acccaagaaa acatttgtcc accctattcg gacaatgaat atccctatat cagccaaatg
    12601 ccatgacagg gaggagtaca caaccccggg aagcacagag agaaagcggt cggtgcgagc
    12661 tttcgtgaac gaattgtgga agtagccccc gagcagtgaa ccaaaccgca tatccagtca
    12721 gatgattcat agatccggac agacatgcca agtagacttc aacgtcagtt ccacgttaca
    12781 ggaacacagt atatcagtac tgacaaagtg cagagccaga ctctgaatac aggtggtacc
    12841 gcggaaacat tttcgccctg ggcaaacaag cccagggcgt tttttactat atttatatat
    12901 cagggtcaaa aagtcgttcg tgcttgcttt aatctgtcac atcaaacccg ccaccccaca
    12961 ctcggcagaa tcagcgcagc gccattctgc accaccctgt attcgccaat acacagctcg
    13021 gaaatttatt tgttttcggg tgcatttgca ggagtcgtag taactcttag tgcctggaaa
    13081 tctgcgttgt tcagaaaaat ctcactgtct gagccgcatc cgcggcgagt ttgagatttt
    13141 tctgaacggt tttagcagat tttcagacac ttagagttcc tagaccccga aaccgcaccc
    13201 gaaaacaaat aaatttccga gcgtcctata cacatacaca aaggaggttt acccaaatat
    13261 gaaacaaata tccggcaaca aactcttagt caaagcctta aaagaagaag gcgtagaata
    13321 cctcttcggc taccccggag cctgtaccat cgacatcagt gacgaactct ataaacagga
    13381 cgacgtcaaa atcatcctcc cccgtcacga acaggccctt gtccacgaag ccgacgccta
    13441 cgccagaacc accggcaaag tcggcgtatg tctggtaacc agcggtcccg gagcaaccaa
    13501 ccttgtaaca ggacttgcaa ccgccaacta tgacagcgta cctcttgtat gcttcaccgg
    13561 ccaggtagcc cgccacctga tcggcaacga tgcatttcag gaagtagaca tcgtaggaat
    13621 caccagaagc atcaccaaat acggcgttac tgtccgcaga cgtgaagacc ttggcagaat
    13681 tatcaaagaa gccttctaca ttgcccgcac cggccgtccg ggacctgtcc ttatcgacct
    13741 tccaaaggac gtaatggcag aacttggcag cgctgagtat cctaaaaatg taaacatccg
    13801 cggatacaag cccaacacag atgtccatat tggccagctc aaacgtgcca tcaaactttt
    13861 aaacaaggca aaacgtcctt tattccttgc aggcggcggt gtagtaatct cccgcgccca
    13921 cgaaatcttc cgggaagtag tagaaaaaac aaaagtaccg gttgtcacaa ccgtaatggg
    13981 caaaggttcc attcctactg accatccgct ttatatcgga aacctcggca tgcatggtgc
    14041 ctatgcagca aacatggctg tcagcaactg cgatgtattg ttctccatcg gaaccagatt
    14101 caatgacaga atcaccggaa aacttcatga atttgcacca catgcccaga ttatccacat
    14161 tgatattgat acagcatcca tttcccgaaa cattcaggtg gatatcccca ttgttgctga
    14221 tgcaaaagag gctatcacca aaatgaacga atacgtccag gaatgttcaa cggacaagtg
    14281 gcttaacctg atcaaaaact ggaaagaaga gcatccgctt aaaatgcgtc caaatgatct
    14341 tttaagtccg atggatatcc tgaaagagat caacgaacag tttgagaaca gtattatcgt
    14401 aacagatgta ggacagcatc agatgcttgt ctcccagtat gcggaaatca cagagggcaa
    14461 acagatgatc atgtccggtg gtctgggaac aatgggctat ggtcttccag gcggcatcgg
    14521 agccaaaatc gggaatcccg acagacctgt catcgttatc tccggtgacg gcggtgtgca
    14581 gatgaacatt caggagcttg caactgcagt tctggaggaa cttcctgtta tcctgtgcat
    14641 ctttaacaat gaataccttg gaatggtacg ccagtggcag aagcttttct acggcaaacg
    14701 ctatgctatg accaatctgc gcgcaggagc actttcccgc cgcactgaag gcatggaata
    14761 tccacagtac acaccggatt tcatcagact tgcagagagc tacagggcaa aaggaatccg
    14821 tgtcacaaag aaagaggaaa ttgcagcagc cttcgaggaa gcaaaaaaga acacaaaggc
    14881 acctacagta attgaattca tcattgaccc tgaggaaatg gtttatccta tgatcaaacc
    14941 aggcggaact ctggaagata tgattatgga ctgttgatca ggaggaaaat tattatggat
    15001 aaaggaatga aaaaaagatg gatttctctc tatgttgaga accaggtagg tgttctgtcc
    15061 aaaatctccg gacttttctc cggaaaaagc tacaatctgg acagtcttac tgtaggaacc
    15121 accgaggacc ccacagtatc tcgaatgacg atcgcaactg tcagtgatga tgaaactttt
    15181 gaacagatca aaaaacagtt gaaccgtatg atcgaggtta ttaaggttat tgatttcaca
    15241 gacgtatttg tccgcatgaa agagattctg tatattaagg tttttaactg ttccaaagaa
    15301 gataaggttg aactgtttca gattgccgaa accttcaagg caaaggtcat tgactatggc
    15361 aaagatagtc tactcctgga atttgtccag acagcaacca agaatgacgc agtagtgaaa
    15421 ctgatcaagg aagaatttca cagaattgaa gtggtacgtg gaggaagcgt aggaattgag
    15481 tctattagta tgatggaacg ataatctcat aatcaatatt ttttacagga tatagtgtgt
    15541 agatacttct caacgaacaa cgctatatcc tgtatttatt ttcaaacata ctataaaaca
    15601 ttgcagtttt aatcaaatgt gttattgttt acaagagcgt tattcgaaag aaaatgcatc
    15661 tgttttccac atctgacagt ctggtggata aagtcatcca ctttacagtc tggttaaatt
    15721 cgtgaggcga cctgcaaggc ggcgtctaca caccggaaat ttttaccgga agatatttct
    15781 tgtttcatat cttttgttct gatgcatatt tttcaaaacg cctgattcct catactctaa
    15841 actgtctgaa aagcagggga cgcattgcgc cgttttatca gaccaaaagg agaattcata
    15901 tgaacacaac aacaactact acaacagct
//
