LOCUS       c00059_gnlPro..        12579 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|HDDIGPKE_59.
ACCESSION   c00059_gnlPro..
VERSION     c00059_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-06 04:11:18
            Original ID  :: gnl|Prokka|HDDIGPKE_59
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 12579
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..12579
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[2834:12578]"
                     /cutoff="10000"
                     /detection_rule="(minimum(1, [HAAA1, HG2B1, HG2B2, HGD-D,
                     HleuD1, HleuD2, HleuS1, HleuS2, Lactoyl-CoA1,
                     Lactoyl-CoA2]) and minimum(1, [ACP_syn_III, ACP_syn_III_C,
                     AcetylCoA_hyd_C, AcetylCoA_hydro, Acyl-CoA_dh_1,
                     Acyl-CoA_dh_2, AdoHcyase_NAD, AlaDh_PNT_C, BcrAD_BadFG,
                     Biotin_lipoyl, Carboxyl_trans, CoA_trans,
                     CoA_trans_230_acto, CoA_trans_6_Glutaconate, CoA_transf_3,
                     ECH_1, ECH_2, ETF, ETF_alpha, FGGY_C, HCDH, HCDH_N,
                     Hacid_dh, Hacid_dh_C, Mal_decarbox_Al, Peptidase_M22,
                     Peptidase_M23, Thiolase_C, Thiolase_N, ketoacyl-synt]) and
                     not (minimum(2, [AcetylCoA_hyd_C, BcrAD_BadFG, CoA_trans,
                     CoA_trans_230_acto, Mal_decarbox_Al]) and Lactoyl-CoA2 and
                     Lactoyl-CoA1) and not (minimum(4, [ACP_syn_III,
                     ACP_syn_III_C, Acyl-CoA_dh_1, Acyl-CoA_dh_2, AlaDh_PNT_C,
                     BcrAD_BadFG, ECH_1, ECH_2, ETF, ETF_alpha, HCDH, HCDH_N,
                     Hacid_dh, Hacid_dh_C, IlvN, NAD_Gly3P_dh_N, Thiolase_C,
                     Thiolase_N, ketoacyl-synt]) and HAAA1 and not HleuS1))"
                     /neighbourhood="10000"
                     /product="Others_HGD_unassigned"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      2835..12578
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(minimum(1, [HAAA1, HG2B1, HG2B2, HGD-D,
                     HleuD1, HleuD2, HleuS1, HleuS2, Lactoyl-CoA1,
                     Lactoyl-CoA2]) and minimum(1, [ACP_syn_III, ACP_syn_III_C,
                     AcetylCoA_hyd_C, AcetylCoA_hydro, Acyl-CoA_dh_1,
                     Acyl-CoA_dh_2, AdoHcyase_NAD, AlaDh_PNT_C, BcrAD_BadFG,
                     Biotin_lipoyl, Carboxyl_trans, CoA_trans,
                     CoA_trans_230_acto, CoA_trans_6_Glutaconate, CoA_transf_3,
                     ECH_1, ECH_2, ETF, ETF_alpha, FGGY_C, HCDH, HCDH_N,
                     Hacid_dh, Hacid_dh_C, Mal_decarbox_Al, Peptidase_M22,
                     Peptidase_M23, Thiolase_C, Thiolase_N, ketoacyl-synt]) and
                     not (minimum(2, [AcetylCoA_hyd_C, BcrAD_BadFG, CoA_trans,
                     CoA_trans_230_acto, Mal_decarbox_Al]) and Lactoyl-CoA2 and
                     Lactoyl-CoA1) and not (minimum(4, [ACP_syn_III,
                     ACP_syn_III_C, Acyl-CoA_dh_1, Acyl-CoA_dh_2, AlaDh_PNT_C,
                     BcrAD_BadFG, ECH_1, ECH_2, ETF, ETF_alpha, HCDH, HCDH_N,
                     Hacid_dh, Hacid_dh_C, IlvN, NAD_Gly3P_dh_N, Thiolase_C,
                     Thiolase_N, ketoacyl-synt]) and HAAA1 and not HleuS1))"
                     /neighbourhood="10000"
                     /product="Others_HGD_unassigned"
                     /protocluster_number="1"
     cand_cluster    1..12579
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(minimum(1, [HAAA1, HG2B1, HG2B2, HGD-D,
                     HleuD1, HleuD2, HleuS1, HleuS2, Lactoyl-CoA1,
                     Lactoyl-CoA2]) and minimum(1, [ACP_syn_III, ACP_syn_III_C,
                     AcetylCoA_hyd_C, AcetylCoA_hydro, Acyl-CoA_dh_1,
                     Acyl-CoA_dh_2, AdoHcyase_NAD, AlaDh_PNT_C, BcrAD_BadFG,
                     Biotin_lipoyl, Carboxyl_trans, CoA_trans,
                     CoA_trans_230_acto, CoA_trans_6_Glutaconate, CoA_transf_3,
                     ECH_1, ECH_2, ETF, ETF_alpha, FGGY_C, HCDH, HCDH_N,
                     Hacid_dh, Hacid_dh_C, Mal_decarbox_Al, Peptidase_M22,
                     Peptidase_M23, Thiolase_C, Thiolase_N, ketoacyl-synt]) and
                     not (minimum(2, [AcetylCoA_hyd_C, BcrAD_BadFG, CoA_trans,
                     CoA_trans_230_acto, Mal_decarbox_Al]) and Lactoyl-CoA2 and
                     Lactoyl-CoA1) and not (minimum(4, [ACP_syn_III,
                     ACP_syn_III_C, Acyl-CoA_dh_1, Acyl-CoA_dh_2, AlaDh_PNT_C,
                     BcrAD_BadFG, ECH_1, ECH_2, ETF, ETF_alpha, HCDH, HCDH_N,
                     Hacid_dh, Hacid_dh_C, IlvN, NAD_Gly3P_dh_N, Thiolase_C,
                     Thiolase_N, ketoacyl-synt]) and HAAA1 and not HleuS1))"
                     /kind="single"
                     /product="Others_HGD_unassigned"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..12579
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="Others_HGD_unassigned"
                     /region_number="1"
                     /rules="(minimum(1, [HAAA1, HG2B1, HG2B2, HGD-D, HleuD1,
                     HleuD2, HleuS1, HleuS2, Lactoyl-CoA1, Lactoyl-CoA2]) and
                     minimum(1, [ACP_syn_III, ACP_syn_III_C, AcetylCoA_hyd_C,
                     AcetylCoA_hydro, Acyl-CoA_dh_1, Acyl-CoA_dh_2,
                     AdoHcyase_NAD, AlaDh_PNT_C, BcrAD_BadFG, Biotin_lipoyl,
                     Carboxyl_trans, CoA_trans, CoA_trans_230_acto,
                     CoA_trans_6_Glutaconate, CoA_transf_3, ECH_1, ECH_2, ETF,
                     ETF_alpha, FGGY_C, HCDH, HCDH_N, Hacid_dh, Hacid_dh_C,
                     Mal_decarbox_Al, Peptidase_M22, Peptidase_M23, Thiolase_C,
                     Thiolase_N, ketoacyl-synt]) and not (minimum(2,
                     [AcetylCoA_hyd_C, BcrAD_BadFG, CoA_trans,
                     CoA_trans_230_acto, Mal_decarbox_Al]) and Lactoyl-CoA2 and
                     Lactoyl-CoA1) and not (minimum(4, [ACP_syn_III,
                     ACP_syn_III_C, Acyl-CoA_dh_1, Acyl-CoA_dh_2, AlaDh_PNT_C,
                     BcrAD_BadFG, ECH_1, ECH_2, ETF, ETF_alpha, HCDH, HCDH_N,
                     Hacid_dh, Hacid_dh_C, IlvN, NAD_Gly3P_dh_N, Thiolase_C,
                     Thiolase_N, ketoacyl-synt]) and HAAA1 and not HleuS1))"
                     /tool="gutsmash"
     CDS             260..2833
                     /locus_tag="ctg59_1"
                     /transl_table=11
                     /translation="MRLLVIDGNSIANRAFYGIKLLTTKDGRYTNAIYGFLNILLSLLK
                     ECQPDEVAVAFDLKAPTFRHKMYDGYKATRHAMPEELAQQMPVLKQLLADLGYRTVTAE
                     GWEADDILGTLAAACAARKDDCFLATGDRDSLQLVSESTTVLLAATVMGRSKTVVMDED
                     AIQEKYGLAPKQLIEVKSLMGDTSDNIPGVKGIGEKTALSLVQAFGSLEGVYQNIDDKR
                     IKPKQREHLLEDKPMAELSHTLGTIRTDAPIDTAEGSYTVGEGNKPAAVRLLQELEIHS
                     LIPRFGLDGVAPEAAAEEQAVELPEAELTPLPLTPAGHYLVAARPAVTGKQGTRNVVLQ
                     PESWYAVQDTTVYPLEDAELVRLLDNTDVTLDVFNSAPLYAKAMAAGGWGSSIVWDGKL
                     AAYLLDASASKYQISELIPTYKAAAAFTCTDYPDAGRLADLFARMKAEITACGEDALYN
                     EIEFPLAQVLADMTRTGVLVDKDGIEQFGVKLREELEQVLTRIHMETGSATFNPNSPKQ
                     LGEMLFDTMGLPHGKKTQRGWSTDAETLESLREYPLVEDVLQYRAYQKLNSTYVEGLLK
                     VIGEDGRIHSTFNQTEARTGRLSSDNPNLQNIPIRTELGSQLRAYFVAKPGCVLVDADY
                     SQIELRILAHITGDEHMQQAFLNGEDIHRSTAAKIYGIPQSEVTPRLRSSAKAINFGIM
                     YGKGAYSLSKDIGVTVKEADAFLKNYLAAFPSVSGYMDKTIADAKANGYVSTLFGRRRT
                     LPELASTNFNVRASGERMARNTPIQGTAADVIKLAMVRVWKRLRDEKMASRLILTVHDE
                     LIVEAPEAEAEQAARILREEMEGCVQYAVPLSTDVHAGKNWLEAH"
     CDS             2835..3842
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Others_HGD_unassigned: Peptidase_M22"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg59_2"
                     /sec_met_domain="Peptidase_M22 (E-value: 5.8e-94, bitscore:
                     303.8, seeds: 111, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIILGIESTCDETAAALVEDGRHLLSNVISTSVKEQALYGGVVPE
                     IASRRHCEFISATVKKALLDAGKTIDDVDAVAVTFAPGLIGAVLVGVNFAKGLAYSAGK
                     PLVPVHHLRGHIAALYLTHPELKPPFLCLVASGGHSHIVEVQDYTHYHILGHTVDDAAG
                     EAFDKVARTLGLPYPGGPSVAAAAKTGDPKAYRLPVPHVEGKYNVSFSGLKTAVLNEVN
                     KAQMKGEEVNVPDLAASFQERIAGILAEKLLLAAADTGAKQVCLAGGVAANGRLRQLVN
                     DGAQKLGAKVYLPELKFCGDNGAMIAAQGYYQYIAGHTAGLELNGLPTLPIDYE"
     CDS             3865..4599
                     /locus_tag="ctg59_3"
                     /transl_table=11
                     /translation="MTERNPILQSLFDRKSVRVYEEKPIPAEMKQAILEAAAQAPSAGC
                     QQLYTILDITDPALKEALAESCDHQPFIAKAPLVLVFCADCKKWYDAYLEAGCTPRTPG
                     VGDLMLAVTDAAIAAQNAVVAAESFGIGSCYIGDIMENCDTQRSLLHLPDYVFPAVMLV
                     FGWPTQQQKDRVKPQRCAMEHIVHENGYRTMDGAELRDTFGYKAGNAPFDQWCTAFCNR
                     KYNSDFSKEMTRSVEEYLGQFR"
     CDS             complement(4680..5579)
                     /locus_tag="ctg59_4"
                     /transl_table=11
                     /translation="MAVEITEEFVWQSIPRRARDSHKGTFGSVLAVAGSAFYRGAALLA
                     AEGALRTGAGIVTLASVEPVVSAAVTRLPECCLCPCKEGAQGGIAPENVPLLRRQKATV
                     LLLGPGLGGTAQSAARATETRTLVQQLLPGFVGAAVLDADGLNAAAQLLAEGKPFPHPA
                     GELVVTPHPGEMARLTGLSVAELAADREGIALRYAKAWNAVVVLKGARTVVTSPDGRAC
                     VNPTGNPGLARGGSGDVLAGMLAALLACGLPAYQAAACAVYLHGAAADRAAAKRGEYGM
                     LPHDILPELGALFAENQR"
     CDS             complement(5730..8312)
                     /locus_tag="ctg59_5"
                     /transl_table=11
                     /translation="METTQKQIVLGILAHVDSGKTTLSEAMLYRAGAIRKLGRVDHGDA
                     FLDTDSLEKARGITIFSKQALLTAGNTAITLLDTPGHVDFSTETERTLQVLDYAVLVVS
                     GTDGVQSHTETLWRLLRRYHVPTFVFVNKMDLPGMTREQLLSQLNHRLGEGFVDFGAEP
                     AARNEALALCDEQLMEKMLDAGTLTDADMIPAVARRHVFPCWFGAALRLDGVDALLDGL
                     DRYTRPAPALQAFGARVFKVSQDEQGARLTWLRVTGGELKVKALLTGEADGEPWAEKAN
                     QLRLYSGAKYTLTEAIGPGQVCAVTGLTHAKPGAGLGAERDSDVPVLEPVLSYQVLLPE
                     GADVHAALGKLHRLEEEEPQLHVVWNETLGEIHVQLMGEVQLEVLRSLLAERFGLEVSF
                     GPGGILYKETITEPMEGVGHYEPLRHYAEVHLLLEPLPRGSGMQFAADCREEVLDKNWQ
                     RLVLTHLEEKQHLGVLTGAPLTDVKITLLTGRAHLKHTEGGDFRQATYRAVRQGLMLAK
                     SQLLEPWYAFRLEVPVENIGRAMSDIQRMEGSFDPPESGAETATLTGFAPVSTMRSYPM
                     EVVSYTRGRGHLSLTLDGYRPCHNAQQVIAETGYQPEHDLDNPADSVFCAHGAGFVVPW
                     SEVRSHMHVESGWGKAKSARPEVQAAPQRRAMAYRATLEEDAELLKIFERTYGPIKRDP
                     LAAFRPVQKTERPDFAAEQWEIVPEYLLVDGYNIIFAWDELNALAKESLDAARRKLMEI
                     LCNYQGYQKCVLILVFDAYRVPGSPGAIEQYHNIHVVYTKEAETADMFIERVTHEIGKS
                     RRVRVATSDGMEQVIILGHGALRVSARMFHEEVQNVEKQIRALVQGQA"
     CDS             complement(8489..9394)
                     /locus_tag="ctg59_6"
                     /transl_table=11
                     /translation="MEKPAAACYHLPGLFEFYELYRRFLPLYREHREYFYDWCTIGSIY
                     GAPAGCIWGGGRISCGGAAAREVLALLREYGISGRLTFSNSLLRAEHLADPQCNALCEQ
                     FAKSGSVPNGVIVHSDLLADYLRQRWPELYLVSSTTKVLTELAQLRQELAKPQFRYVVP
                     DFRLNPALEQLRTLPPEQKAKVEFLCNECCWFGCTERKRCYETVSRQNLGEDCPDHRCA
                     APDAAGGYRFSKAMRSPGFIGVEDIRQRYLPAGFSQFKIEGRGLGSALVLEFLLYYMIK
                     PEYQLQVREEIYLDNMLDLF"
     CDS             complement(9478..10794)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Others_HGD_unassigned: HGD-D"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg59_7"
                     /sec_met_domain="HGD-D (E-value: 2.7e-22, bitscore: 69.0,
                     seeds: 370, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MEYHYPKFTPEMKKTHTILIPNMAVTQFRLMEYALRCEGYKCELL
                     GNCGSAVAQLGLKYVHNDTCYPALLVIGQFLDALNSGKYDLEHTALLITQTGGGCRASN
                     YIHLLRKALVKAGYPQIPVASLNFSGLEKDSGFQMTLPLARKCIACIFYGDMLCALRNQ
                     VAPYENEKGAADRMVDRWIARLGRALLAGKGFTSREMKHTFPLIAKEFATIPVTRVPKV
                     KVGVVGEIYVKYSPLGNNDLQKFLESQDCEVNFPGLMGFVQYCAFNMGEDHVLYGGKLA
                     VKVGTDQFLNWLDSVERVMLKAETDAGFYAPGPFKELVEKPKGVISLGAKMGEGWLLTA
                     EMIELVQGGYGNIVCAQPFGCLPNHIVGKGMVNKIRALYPSANITPIDYDPSATRVNQE
                     NRIKLMLAVAKERLNAPAEAQPLTAEQLAGGAPQVGATV"
     CDS             complement(10884..12578)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Others_HGD_unassigned: BcrAD_BadFG"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Others_HGD_unassigned: HGD-D"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg59_8"
                     /sec_met_domain="HGD-D (E-value: 3.3e-16, bitscore: 49.0,
                     seeds: 370, tool: rule-based-clusters)"
                     /sec_met_domain="BcrAD_BadFG (E-value: 3.6e-22, bitscore:
                     68.1, seeds: 18, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="KCFKIEDGAISNIFLNEACSSGCGSFLQTFAQALGYDVKEFAALG
                     LFADRPVDLGSRCTVFMNSSVKQAQKDGASIENISAGLSISVVKNALYKVIRASSPEEL
                     GRKIVVQGGTFYNEAVLRAFEKEMGVEVIRPDIAGLMGAYGAALYGLRQSHKNNQTTSA
                     MMDEQELEKFAQQVVSVKCGGCGNHCQLTVNTFADGRKFISGNRCDKPVTGKSEDNSLN
                     LYAYKQQLLASYKPVPGKRGSIGIPLCLGFYELLPFWYAFWTSLGFAVHTSPVSTRGLY
                     LAGQATIPSDTACFPAKLSHGHIKALSQMQLDAIFYPCLTYNVDEGLGDNHYNCPVVAY
                     YPEVLAGNCPELEGKKFIYDYVGIHRPKDFVHKMAKDVLPKYFGGISEREVQAAADAAY
                     AEYEAHMAKIRVKGSEIIDEARRQGKRIIVLAGRPYHVDPEVNHGIDHLITRHGAAVVT
                     EDSISNRVQKFPTSVLNQWTYHSRLYAAAKYCTTQKDMDLVQLVSFGCGVDAITTDETR
                     EILQRGNKLYTQLKIDEITNLGAVNIRLRSLFAALDERDEAAAEKSE"
ORIGIN
        1 acccgcttct aattatagca aaaggaggtt ctttttctac cgtttcaacg ctacggctct
       61 tttcttccac aagcatagct tgtggttttc tatatgaatt atgcgattgt cacggcttac
      121 gagccgcgac aatcgcattt ttacgagaga cggcatcacg aaaagcaacc acttctcttt
      181 tttgcgcaaa aagctcccgc gcggtacagt tttgtgctat actataaggt gtgagattac
      241 gcaacggagg aactgcatta tgcgtttact ggtcattgac ggcaacagca ttgccaaccg
      301 cgctttttac ggcatcaagc tgctgaccac caaggacgga cgttacacca acgccatcta
      361 tggctttttg aacattctgc tctccctgct caaggagtgc cagccggacg aggtcgccgt
      421 ggcttttgac ctgaaagccc ccaccttccg gcataaaatg tacgatggct acaaagccac
      481 ccgccacgct atgcccgagg agctggcaca gcagatgccg gtgctcaagc agctgctggc
      541 agaccttggc taccgcaccg ttaccgccga gggctgggaa gcggacgata ttctgggcac
      601 actggccgct gcctgcgccg cccggaagga cgactgtttc cttgccaccg gagaccggga
      661 cagcctgcag ctggtgagcg agagcaccac cgtactgctt gctgccaccg taatggggcg
      721 cagcaagacc gtggtgatgg acgaggacgc cattcaggaa aaatacggcc ttgcgcccaa
      781 gcagcttatc gaggtgaaga gcctgatggg cgatacctca gataacatcc ccggcgtgaa
      841 gggcatcggc gaaaagaccg cgctttctct ggtgcaggcc ttcggctcgc tggagggcgt
      901 gtaccagaac attgacgaca agcgcatcaa acccaagcag cgggagcact tgttagaaga
      961 caagcccatg gccgagctga gccatacgct gggcaccatc cgcaccgatg cccccatcga
     1021 caccgccgag ggttcctaca ccgtgggcga gggcaacaaa cccgccgccg tgcggctttt
     1081 gcaggagctg gagatccact ccctgatccc ccggttcggg ctggacggcg tagcgccgga
     1141 agccgctgct gaggagcagg ctgtggagct gccggaagca gagctcactc ccctgcctct
     1201 gacccccgcc gggcattatc tggtggctgc ccgccccgcc gttaccggca agcagggcac
     1261 ccgcaacgtg gtattgcagc cggaaagctg gtacgccgtg caggatacca ccgtctaccc
     1321 gctggaggat gctgagctgg tgcggctgct ggacaatacg gatgtgacgc tggatgtgtt
     1381 caactccgcg cccctctacg ccaaagccat ggccgccggc ggctggggca gcagcatcgt
     1441 ctgggacggc aaactggccg cctatctgct ggacgcctcc gcctccaagt atcagatcag
     1501 cgagctgatt cccacctaca aggccgctgc cgcctttacc tgcaccgatt acccggacgc
     1561 cggacggctg gccgacctgt ttgcccgaat gaaggccgag atcaccgcct gcggagagga
     1621 tgcactgtac aacgagatcg agttcccgct ggcacaggtg ctggccgata tgacccgcac
     1681 cggcgtgctg gtggacaagg acggcattga gcagttcggc gtaaagctgc gggaagaact
     1741 ggagcaggtg ctgacccgca tccacatgga gaccggcagc gccaccttca accccaacag
     1801 ccccaagcag ctgggcgaga tgctgttcga caccatgggg ctgccccacg gcaaaaagac
     1861 ccagcgcggc tggtctaccg atgccgaaac gctggaaagc ctgcgcgagt accctctggt
     1921 agaggacgtt ttgcagtacc gcgcctacca gaaactgaac tccacctatg tggagggtct
     1981 gctcaaggtc atcggcgagg acgggcgcat ccactccacc tttaaccaga ccgaagcccg
     2041 caccggacgg ctctcttccg ataatcccaa cctgcagaat atccccatcc gcaccgaact
     2101 gggcagccag ctgcgcgcct actttgttgc aaagccgggc tgtgtgctgg tggacgcaga
     2161 ttacagccag atcgaactgc gcattctggc gcacatcacc ggggacgagc acatgcagca
     2221 ggcctttttg aacggcgagg atatccaccg cagcaccgct gccaagatct acggcattcc
     2281 gcagagcgag gtgacgcccc ggctgcgctc ctctgccaag gccatcaact tcggcatcat
     2341 gtacggcaag ggcgcgtaca gcctttccaa ggatatcggc gtgaccgtga aggaggctga
     2401 cgccttcctc aagaattatc tggcggcctt ccccagcgtg agcggctata tggacaagac
     2461 cattgcggat gccaaggcaa acggctatgt atccaccctg ttcggccgcc gccgcaccct
     2521 gccggagctg gccagcacca acttcaacgt gcgcgccagc ggcgagcgta tggcccgcaa
     2581 cacccccatt cagggcaccg ctgcggacgt gatcaagctg gccatggtgc gggtgtggaa
     2641 gcgcctgcgg gatgaaaaaa tggccagccg cctgatcctg accgtccacg acgaactgat
     2701 cgtggaggcc ccggaggcgg aggccgagca ggctgcccgc atcctgcggg aggaaatgga
     2761 aggctgcgtg cagtacgcgg tgcccctgag taccgatgtg cacgcaggca aaaactggct
     2821 ggaggcacac taaaatgatc attctcggaa tcgagtctac ctgtgacgaa actgccgctg
     2881 cactggtgga ggacggacgg cacctgctga gcaacgtcat ctccaccagc gtcaaggagc
     2941 aggcactgta cggcggcgtt gtgccggaga tcgccagccg acgccactgc gagtttatca
     3001 gtgctacggt caaaaaagcc ctgctggacg cgggcaagac catagacgat gtggacgccg
     3061 tggctgtcac ctttgcgccg gggctcatcg gtgcggtgct ggtgggcgtg aactttgcca
     3121 agggtctggc ctactcggcg ggcaagccgc tggtgccggt gcaccatctg cggggacaca
     3181 tcgctgcgct ctacctgacc cacccggagc tcaagccgcc ctttttgtgt ctggtggcct
     3241 ctggcgggca cagccacatc gtggaggtgc aggactacac ccactaccac attctgggtc
     3301 ataccgtaga cgatgctgcg ggcgaagcct ttgacaaggt ggcccgcaca ctgggtctgc
     3361 cctaccccgg cggccccagc gtagccgccg ccgccaagac cggcgacccc aaggcctacc
     3421 gcctgccggt gccccatgtg gagggcaagt acaacgtgag cttttccggt ttaaagaccg
     3481 ccgtgctcaa cgaggtgaac aaggcgcaga tgaagggcga ggaagtgaac gtacccgacc
     3541 ttgctgccag ctttcaggag cgcatcgcag gcattctggc cgaaaagctg ctgctggctg
     3601 ctgccgatac cggggcaaag caggtttgcc ttgccggcgg cgtagccgcc aacggccgtc
     3661 tgcgccagct ggtgaacgac ggtgcccaga agctgggtgc caaggtctac ctgccggaac
     3721 tgaagttctg cggcgacaac ggcgcgatga ttgccgcgca gggctactac cagtacattg
     3781 ccgggcatac cgccgggctg gaactgaacg gcctgcccac cctgcccatc gactatgaat
     3841 aaacacaaca tcggaggtgt tcccatgact gagcgcaatc ctatcctgca aagcctgttc
     3901 gaccgcaagt cggtgcgggt gtatgaagaa aagcccatcc ctgccgagat gaagcaggcc
     3961 attttggaag ctgccgcaca ggcgccctct gcgggctgtc aacagctata taccatttta
     4021 gacatcaccg acccggcact gaaagaagcg ctggccgaaa gctgcgacca ccagcccttt
     4081 attgccaaag caccgctggt gctggtgttc tgcgccgact gcaaaaagtg gtacgacgcc
     4141 tacttagagg ccggttgcac gccccgcact ccgggtgtgg gcgatttgat gctggcagtc
     4201 accgatgctg ccattgccgc ccagaacgcc gtagtcgccg ccgaaagctt tggcatcggc
     4261 tcgtgctaca tcggggacat catggaaaac tgcgacaccc agcgcagcct gctgcatctg
     4321 ccggactatg tgttcccggc ggtgatgctg gtgttcggct ggcccaccca gcagcagaag
     4381 gaccgcgtaa agccccagcg ctgcgccatg gagcatatcg tgcacgaaaa cggctaccgc
     4441 accatggacg gcgcagagct gcgggacacc ttcggctaca aagccggaaa cgcccccttt
     4501 gaccagtggt gcaccgcctt ttgcaaccgc aaatataact ccgatttttc caaggagatg
     4561 acccgctccg tggaggaata tctcggccag ttccggtgat ctaaaacgtt tctgagccac
     4621 aaattatagc aacaaaaagc ggcagctgca cggtattttg tgcagctgcc gcttctcgtt
     4681 tatctttggt tttccgcaaa cagtgcgccc aactccggca ggatatcgtg gggcagcatt
     4741 ccgtactcgc cgcgctttgc ggcggcgcgg tcggcggcgg caccgtgcag gtataccgcg
     4801 caggcagcgg cttgataggc gggcaaaccg caggccagca gcgccgcaag catcccagcc
     4861 agtacatccc cgctgccgcc ccgggcaagc cccgggttgc cggtggggtt cacacacgca
     4921 cgcccatccg ggctggtcac cacagtgcgt gcccccttca gcaccaccac ggcattccac
     4981 gccttggcat agcgcagggc gataccctcc cggtcggcgg caagctctgc taccgaaagg
     5041 ccggtcaggc gcgccatctc gccggggtgc ggggtgacta ccagttctcc cgccgggtgc
     5101 ggaaagggct taccctcggc cagcagctgt gcggcggcgt tcagaccgtc tgcgtccagc
     5161 accgcagccc ccacaaagcc gggcagcagc tgctgcacca gcgtgcgggt ctcggtggcc
     5221 cgggcggcgc tttgcgctgt gccgccaagg ccggggccca gcagcaatac ggtagccttc
     5281 tgccgccgga gcagcggcac attttccggc gcaatgccgc cctgtgcgcc ctccttacag
     5341 gggcacaggc agcactccgg caggcgggta acggcggcgc tgaccaccgg ctccacactg
     5401 gcaagggtga cgatgcccgc cccggtgcgc agcgcaccct cggctgccag cagcgcagcg
     5461 ccccggtaaa aggcgctgcc cgccactgcc agcacgctgc caaaggtgcc cttatgactg
     5521 tcccgggcac ggcgcgggat gctttgccag acaaattctt cggtaatttc cacagccatg
     5581 ggtgcacctc cagagaacga tttcaaatgc cctctgcgtt gctgtgggca tttttagcgg
     5641 aatcattatt ttaagattgt cgttttggaa aatctgcgga ttttccaaaa cgactttttc
     5701 acaagagagg aattttttcg ggataacttt tacgcctgtc cctgcacaag ggcgcggatc
     5761 tgtttttcca cgttctgcac ttcctcgtgg aacatccggg cagacacgcg cagtgcaccg
     5821 tggccaagga taatgacctg ctccatgccg tccgaggtcg ccacgcgaac acggcggctc
     5881 ttgccgatct catgggtgac ccgctcgatg aacatatcgg cggtctccgc ctccttggtg
     5941 tagaccacat ggatattgtg gtactgctcg atggcgccgg ggctgccggg cacgcggtag
     6001 gcatcgaaca ccagaatgag cacgcatttc tggtagccct gatagttgca caggatctcc
     6061 atcagcttgc ggcgggcagc gtccaagctt tccttcgcca gcgcgttcag ctcgtcccac
     6121 gcaaaaatga tgttgtagcc gtccaccagc agatactccg ggacaatttc ccactgctct
     6181 gcggcaaaat ccgggcgttc ggtcttttgc accgggcgga aggccgccag cgggtcccgc
     6241 ttgatggggc cgtaggtgcg ctcaaaaatt ttgagcagtt cggcgtcctc ctccagcgtg
     6301 gcgcggtagg ccatggcgcg gcgctggggc gcagcctgca cctccgggcg ggcggacttt
     6361 gccttgcccc agccgctttc cacgtgcatg tggctgcgca cctcactcca cggcaccaca
     6421 aagcccgcac catgggcgca gaacacagag tctgcggggt tgtccagatc atgctccggc
     6481 tggtagccgg tttctgcaat gacctgctgc gcgttgtggc aggggcggta gccgtccagc
     6541 gtcaggctca ggtgtcccct gccccgggtg tagctgacca cctccatggg gtagctgcgc
     6601 atggtggata ccggcgcaaa gccggtcagg gtggcggtct ccgcgccgct ttccggcggg
     6661 tcaaaactac cctccatgcg ctggatatcg ctcatggcgc ggccgatgtt ctccaccggc
     6721 acctccagcc ggaaggcata ccacggctct aacagctggc ttttggccag catcagcccc
     6781 tgccgcacgg cgcggtaggt ggcctgccgg aaatcgccgc cctcagtgtg cttgaggtgc
     6841 gctctgccgg tgagcagggt aatttttaca tcggtcagcg gtgcgccggt caaaacgcca
     6901 aggtgctgct tttcttccag atgggtcagt accagcctct gccagttttt atccagcacc
     6961 tcttccctgc aatcggcggc aaactgcatc ccgctgcccc ggggcagcgg ttccagcagc
     7021 agatgcacct cggcatagtg gcgcagcggc tcgtaatggc ctacgccctc catgggctcg
     7081 gtgatggtct ccttatacaa aatgccgccc gggccaaagg atacttccag cccgaaccgc
     7141 tcggccaaca ggctgcgcag cacctccagc tgcacctcgc ccatcagctg cacatggatc
     7201 tcgcccagtg tctcgttcca caccacatga agctggggtt cttcctcctc cagccggtgc
     7261 agcttgccca gcgcggcatg cacatctgcg ccctccggca gcagcacctg atagctgagc
     7321 accggttcca gcaccggcac atcgctgtcc cgctctgccc caagcccggc gccgggcttt
     7381 gcatgggtca ggccggtcac ggcgcacacc tgtcccgggc cgatggcctc ggtcagggta
     7441 tattttgcgc cggagtacag ccgcagctgg ttcgcctttt ccgcccacgg ctcgccgtcc
     7501 gcttcgcctg taagcagagc ctttaccttc agttccccgc cggtgacccg cagccatgtc
     7561 aggcgtgccc cctgctcgtc ctgtgatacc ttgaataccc ttgcgccaaa ggcctgcagc
     7621 gccggggcag ggcgggtgta gcggtccagc ccgtccagaa gtgcatccac tccgtccagc
     7681 cgcagcgctg ccccgaacca gcacggaaaa acgtgccgtc gggcaactgc ggggatcatg
     7741 tctgcatcgg tcagggtgcc tgcatccagc attttctcca tcagctgttc atcgcacagc
     7801 gccagcgcct cgttgcgggc ggcaggttct gcgccaaaat ccacaaaacc ctcgccaagg
     7861 cggtgattca gctggctgag taactgttcc cgggtcatgc cgggcaggtc catcttgttc
     7921 acgaatacaa aggtaggcac atggtagcgc cgcaacagcc gccacagcgt ttcggtatgg
     7981 ctttgcacgc cgtccgttcc gctgaccacc agcacggcgt aatccagcac ctgcaaggtg
     8041 cgctcagtct cggtggaaaa atccacatgg ccgggagtgt ccagcagggt gatagcggta
     8101 ttgcccgccg taagcagcgc ctgcttggaa aagatggtga tgccgcgcgc tttttccaga
     8161 ctgtcggtgt ccagaaaggc gtctccgtgg tccacccgcc ccagcttgcg gatagcaccg
     8221 gcgcggtaga gcatggcctc ggagagggtg gtcttgccgg agtccacatg ggccagaata
     8281 cccagtacga tctgtttttg cgttgtttcc atgcactgct cctataagcc gttttcctaa
     8341 gtactgcgca ccatttccaa aaacagcttt taaaaataat ttcctgttta ttgtaacacg
     8401 ctttgcgggg aaaagaaagt tttcgggcgc aaatcccgca ggcaaaaaac agcaccggac
     8461 agaaaacgct ctgcccggtg caattttctt aaaaaaggtc cagcatattg tccagataga
     8521 tttcctcccg cacttgcagc tggtattccg gctttatcat gtagtagagc agaaattcca
     8581 gcaccagtgc gctgccaagc cccctgccct ctatcttgaa ctgggaaaaa cctgcgggca
     8641 gataccgctg ccggatgtcc tccaccccaa taaacccggg actgcgcatc gccttggaaa
     8701 agcggtagcc cccggcggca tccggggcgg cgcagcggtg gtccgggcag tcctcgccca
     8761 gattctggcg gctgaccgtc tcgtagcagc gcttgcgctc ggtgcagccg aaccagcagc
     8821 actcattgca caaaaattcc accttggcct tttgctccgg cggcagggtg cgcagctgtt
     8881 ccagtgccgg attcagccgg aaatccggca ccacataccg gaactgtggc tttgccagct
     8941 cctgccgcaa ctgcgcaagc tccgtgagca ccttggtggt ggaggacacc agatacaact
     9001 ccggccagcg ctgccgcaga tagtccgcca gcaaatcaga atggacgatc acaccgtttg
     9061 gcacactgcc gctttttgca aactgttcac acagggcgtt gcactgcggg tcggcaaggt
     9121 gctcagcccg cagcagggag ttactgaagg tcagccgccc ggagatgccg tattcccgca
     9181 gcagcgccag cacctcgcgc gcagctgccc cgccgcagga gatgcgtccc ccgccccaga
     9241 tgcagcccgc cggggcgccg tagatagagc cgatggtgca ccaatcgtaa aaatattccc
     9301 ggtgctcccg gtacagcggc aaaaaacggc ggtacagctc gtaaaactcg aacaggccgg
     9361 gcagatgata acaggcagct gcgggctttt ccatagcggt tcctttcctg caaaaaggga
     9421 gctgctgcgt aaaaatgccg tgcagcggct cccctgtttt tatcgtattt gcttttgtta
     9481 cacggtagcg ccgacctgag gggcaccccc ggcaagctgc tctgccgtaa gcggctgggc
     9541 ttctgcgggg gcgttcagcc gctccttggc cacagccagc atcagcttga tgcggttttc
     9601 ctgattgacc cgggtggcgc tggggtcgta gtcgatgggg gtgatgttgg cactggggta
     9661 cagcgcacgg atcttgttca ccatgccctt gcccacgata tggttgggca ggcagccaaa
     9721 aggctgtgca cacacgatgt tgccgtagcc gccctgcacc agctcgatca tctcggcggt
     9781 cagcagccag ccctcaccca tttttgcgcc cagcgagata acgcccttgg gcttttccac
     9841 cagctccttg aaggggcccg gcgcatagaa cccggcgtcc gtctctgcct tgagcatgac
     9901 gcgttccacg ctgtccaacc agttgaggaa ctggtcggtg cctaccttta cagccagctt
     9961 gccgccgtaa agcacatgat cctcgcccat gttgaaggcg cagtactgca caaagcccat
    10021 cagaccgggg aagttcacct cgcagtcctg actttccagg aatttttgca ggtcattgtt
    10081 gcccagcggg ctgtacttga cgtagatctc gcccacaaca cccaccttga ccttgggtac
    10141 ccgggtgacc gggatggtgg caaattcctt tgcgatcagc gggaaggtgt gcttcatttc
    10201 ccgggaagta aagcctttac cggccagcaa ggcacggccc agacgggcga tccagcgatc
    10261 caccatgcgg tcagcagccc ccttttcgtt ctcgtaggga gccacctgat tgcgcagcgc
    10321 acacagcata tcgccgtaga agatgcaggc gatacacttg cgcgccagcg ggagggtcat
    10381 ctggaaaccg ctgtcctttt ccagaccgga aaagttcagg cttgccaccg ggatctgcgg
    10441 gtaaccggcc ttgaccagcg ccttgcgcag cagatggatg tagttggagg cgcggcagcc
    10501 gccgccggtc tgggtgatca gcaaggcagt gtgctccaga tcatacttgc cgctgttcag
    10561 cgcatccaga aactggccga tgaccagcag cgccgggtag caggtatcgt tatgcacata
    10621 cttcagcccc agctgtgcca cggcactgcc gcagttgccc agcagctcac acttgtagcc
    10681 ctcgcagcgc agtgcgtact ccatgagccg gaactgggtc acggccatgt tggggataag
    10741 gatggtgtgg gtctttttca tctccggggt aaatttggga taatgatatt ccataggttc
    10801 ctcctatgtt actctaaaca agatagtctc cgcaaaagct tcccccgccg ggggaagccc
    10861 ttcagcctat ctcaggattt cttttattct gacttttctg cggcggcctc gtcccgctcg
    10921 tccagtgcgg caaacaggct gcgcagacgg atgttcacgg caccgaggtt cgtgatctcg
    10981 tcgatcttca gctgggtgta cagcttgttg ccccgctgca aaatctcgcg ggtctcgtcg
    11041 gtggtaatgg catccacgcc gcagccgaag gacaccagct gcaccagatc catatccttt
    11101 tgggtggtgc agtacttggc ggcagcatac agacggctgt ggtaggtcca ctggttcagt
    11161 acgctggtgg ggaacttctg cacccggttg gagatgctgt cctcggtgac caccgcagcc
    11221 ccgtggcggg tgatcaggtg gtcgatgccg tggttgacct ccgggtctac atggtagggg
    11281 cggcctgcca gcacgatgat gcgcttgccc tgacggcgcg cctcgtcgat gatctcgctg
    11341 ccctttaccc ggatctttgc catgtgtgcc tcgtactccg cataggcggc atcggctgcg
    11401 gcctgcacct cccgctcgga gatgccgcca aagtacttgg gcagcacatc ctttgccatc
    11461 ttgtgcacaa aatccttggg gcggtggatg cccacgtaat catagatgaa ctttttgcct
    11521 tccagctccg ggcagttgcc tgccagaacc tccgggtagt aggccaccac cgggcagtta
    11581 taatggttgt cgcccaagcc ctcgtccaca ttgtaggtca ggcaggggta aaagatggcg
    11641 tccagctgca tctggctcag cgccttgatg tggccgtggc tcagctttgc cgggaagcag
    11701 gcggtatcgc tggggatggt ggcctgtccg gccagataca gcccgcgggt ggacaccggg
    11761 ctggtgtgca ccgcaaagcc aaggctcgtc cagaaggcgt accagaaggg cagcagctcg
    11821 taaaagccca gacacagcgg gataccgata gaaccgcgct tgccgggcac aggcttgtag
    11881 ctggccagca gctgctgctt gtaggcatac aggttcaagc tgttatcctc actttttccg
    11941 gtaacgggct tatcgcagcg gttgccggag atgaacttgc ggccatcggc aaaggtgttt
    12001 acggtcagct ggcaatggtt gccgcagccg ccgcacttga cgctgaccac ctgctgtgca
    12061 aacttttcca gttcctgctc gtccatcatg gcagaggtgg tctggttgtt tttatggctc
    12121 tggcgcaggc cgtacaaagc agcgccgtaa gcgcccatca ggccggcaat gtccggccgg
    12181 atgacctcca cgcccatctc tttttcaaag gcgcggagca cggcttcatt atagaaggta
    12241 ccgccctgca ccacgatctt gcggcccagc tcctccgggc tggaggcgcg gatcaccttg
    12301 tacagcgcgt tcttgaccac gctgatggac aggcctgcgg agatattctc gatgctggca
    12361 ccgtcctttt gcgcctgctt gaccgagctg ttcatgaaca cagtgcagcg gctgcccaag
    12421 tccaccgggc ggtctgcgaa cagacccagt gcggcaaact ccttgacatc atagcccagc
    12481 gcctgcgcaa aggtctgcaa aaagctgccg cagccggagg agcaggcctc gttcaggaag
    12541 atgttgctga tggcaccatc ctcgatcttg aagcacttc
//
