LOCUS       c00025_gnlPro..        13735 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|GNPNIOLG_25.
ACCESSION   c00025_gnlPro..
VERSION     c00025_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-04 01:16:48
            Original ID  :: gnl|Prokka|GNPNIOLG_25
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 13735
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..13735
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[8676:11904]"
                     /cutoff="10000"
                     /detection_rule="(TPP_enzyme_C and not (PFL-like or
                     PFL_6_pcresol or PFL_9_tma or Gly_radical or Gly_430_pcre
                     or Gly_8-9_TMA or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and
                     minimum(2, [ALS_ss_C, AlaDh_PNT_C, Arginase, BKACE,
                     BcrAD_BadFG, Beta_elim_lyase, CPSase_L_D2, Cys_Met_Meta_PP,
                     ELFV_dehydrog, GRDB, Glu_syn_central, Glu_synthase,
                     Gly_reductase, HAAA1, HG2B1, HG2B2, HGD-D, HleuD1, HleuD2,
                     HleuS1, HleuS2, Homoserine_dh, ILVD_EDD, IlvC,
                     Lactoyl-CoA1, Lactoyl-CoA2, Lyase_aromatic, MAAL_C,
                     OKR_DC_1_5_lysine, OKR_DC_1_5_ornithine,
                     OKR_DC_1_7_arginine, OKR_DC_1_C, OTCace, PALP,
                     Proline_reductase, Sacchrp_dh_C, TPL, Thr_dehydrat_C, TnaA,
                     Urocanase]) and not (POR or POR_N or PFOR_II))"
                     /neighbourhood="10000"
                     /product="TPP_AA_metabolism"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      8677..11904
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(TPP_enzyme_C and not (PFL-like or
                     PFL_6_pcresol or PFL_9_tma or Gly_radical or Gly_430_pcre
                     or Gly_8-9_TMA or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and
                     minimum(2, [ALS_ss_C, AlaDh_PNT_C, Arginase, BKACE,
                     BcrAD_BadFG, Beta_elim_lyase, CPSase_L_D2, Cys_Met_Meta_PP,
                     ELFV_dehydrog, GRDB, Glu_syn_central, Glu_synthase,
                     Gly_reductase, HAAA1, HG2B1, HG2B2, HGD-D, HleuD1, HleuD2,
                     HleuS1, HleuS2, Homoserine_dh, ILVD_EDD, IlvC,
                     Lactoyl-CoA1, Lactoyl-CoA2, Lyase_aromatic, MAAL_C,
                     OKR_DC_1_5_lysine, OKR_DC_1_5_ornithine,
                     OKR_DC_1_7_arginine, OKR_DC_1_C, OTCace, PALP,
                     Proline_reductase, Sacchrp_dh_C, TPL, Thr_dehydrat_C, TnaA,
                     Urocanase]) and not (POR or POR_N or PFOR_II))"
                     /neighbourhood="10000"
                     /product="TPP_AA_metabolism"
                     /protocluster_number="1"
     cand_cluster    1..13735
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(TPP_enzyme_C and not (PFL-like or
                     PFL_6_pcresol or PFL_9_tma or Gly_radical or Gly_430_pcre
                     or Gly_8-9_TMA or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and
                     minimum(2, [ALS_ss_C, AlaDh_PNT_C, Arginase, BKACE,
                     BcrAD_BadFG, Beta_elim_lyase, CPSase_L_D2, Cys_Met_Meta_PP,
                     ELFV_dehydrog, GRDB, Glu_syn_central, Glu_synthase,
                     Gly_reductase, HAAA1, HG2B1, HG2B2, HGD-D, HleuD1, HleuD2,
                     HleuS1, HleuS2, Homoserine_dh, ILVD_EDD, IlvC,
                     Lactoyl-CoA1, Lactoyl-CoA2, Lyase_aromatic, MAAL_C,
                     OKR_DC_1_5_lysine, OKR_DC_1_5_ornithine,
                     OKR_DC_1_7_arginine, OKR_DC_1_C, OTCace, PALP,
                     Proline_reductase, Sacchrp_dh_C, TPL, Thr_dehydrat_C, TnaA,
                     Urocanase]) and not (POR or POR_N or PFOR_II))"
                     /kind="single"
                     /product="TPP_AA_metabolism"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..13735
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="TPP_AA_metabolism"
                     /region_number="1"
                     /rules="(TPP_enzyme_C and not (PFL-like or PFL_6_pcresol or
                     PFL_9_tma or Gly_radical or Gly_430_pcre or Gly_8-9_TMA or
                     PFL_acetate1 or PFL_acetate2 or Gly_radical_scatole or
                     PFL_proline or PFL_toluene) and minimum(2, [ALS_ss_C,
                     AlaDh_PNT_C, Arginase, BKACE, BcrAD_BadFG, Beta_elim_lyase,
                     CPSase_L_D2, Cys_Met_Meta_PP, ELFV_dehydrog, GRDB,
                     Glu_syn_central, Glu_synthase, Gly_reductase, HAAA1, HG2B1,
                     HG2B2, HGD-D, HleuD1, HleuD2, HleuS1, HleuS2,
                     Homoserine_dh, ILVD_EDD, IlvC, Lactoyl-CoA1, Lactoyl-CoA2,
                     Lyase_aromatic, MAAL_C, OKR_DC_1_5_lysine,
                     OKR_DC_1_5_ornithine, OKR_DC_1_7_arginine, OKR_DC_1_C,
                     OTCace, PALP, Proline_reductase, Sacchrp_dh_C, TPL,
                     Thr_dehydrat_C, TnaA, Urocanase]) and not (POR or POR_N or
                     PFOR_II))"
                     /tool="gutsmash"
     CDS             complement(2..67)
                     /locus_tag="ctg25_1"
                     /transl_table=11
                     /translation="MALDGIFLRHIKSEIEKEALGA"
     CDS             complement(82..567)
                     /locus_tag="ctg25_2"
                     /transl_table=11
                     /translation="MIKINIICIGKIKEKYFTDAIAEYAKRLTAFCKFNIIELSEERIK
                     SNIPNRSQIDEVIFSEGKRIMQKISPSDYVVAMCIEGKSMSSEELSKLIDNASVSGKST
                     VDFIIGGSYGLDESVKKRADVRLSMSRMTFPHQMARMILSEQIYRAFEISSNGKYHK"
     CDS             complement(589..1377)
                     /locus_tag="ctg25_3"
                     /transl_table=11
                     /translation="LARAVPLFSGSKGNSYYIGSASEGVLIDAGRSCKQIENAMLANGL
                     DMGSIGAVFITHEHTDHCSALRVLAKRYGFKVYSSLGTLNALRAGNKLDPNTDADVITD
                     EVVIGNMRVQRIDTPHDAAESCCYRVTAPDGKSALIATDMGVMLPNVRTAAEQSDFVVL
                     ESNHDINMLKNGFYPYPLKQRILSNRGHLSNEACAKELVNLVEKGTLRLMLGHLSEENN
                     TVPLAMSTSVDLLTSNGMKYKSDYSLDVAPSVSTTKAIIF"
     CDS             complement(1500..2792)
                     /locus_tag="ctg25_4"
                     /transl_table=11
                     /translation="LEKFVVTGGKPLSGEVTISGAKNAAVAIIPAVILCDEPCQIENIP
                     NISDVSLISRILQQMGANVRRINRSSLYIDPTKIRTCNAVTDLVRGMRASYYLLGALLG
                     KYGKAKVALPGGCNFGVRPIDQHLKGFEALGATTQLVDGAIIEAECDNLVGTHVYLDVV
                     SVGATMNIMLAASKAKGQTIIENAAREPHIVDLANFLNSMGADVRGAGTDVIKIRGVEY
                     LHGITYSIIPDQIEAGTYMCAAAATRGCITVKNITPKHLESISAKLREMGVKITEYDEA
                     LKVDASSAPLKRCNIKTMPHPGFPTDCQPQFAALLMSVPGTSIINENVWDNRYQYVSEL
                     IRMGAQISVEGRLAIIEGGVPLTAAPVKATDLRAGAAMIIAALEINGTTEISNIQFIER
                     GYEDVVEKFRALGADIKKVYFTGDNEQELGA"
     CDS             3473..4189
                     /locus_tag="ctg25_5"
                     /transl_table=11
                     /translation="MSETAKEPKKISKRSSEEKIEIIVAIFLGITALATAWASWIGSLH
                     GGNQATNYTKSNNLSSEGNSMWNEASQNLMQDMITWNDINEANLNYQYAESKNDKAEME
                     KYQYQIDQLMSDNCTEEFLEAINWAMDQKENVTPFMKDGYTESYFAEAKATIEESDKLL
                     EQGKKDNANGDAFGLVSVIYSVVLFMLGIVGTFKNLPNRRIVLGVAVVGFILATIYMFT
                     IPMPTGFNILSYFGMA"
     CDS             4392..4709
                     /locus_tag="ctg25_6"
                     /transl_table=11
                     /translation="MENKEKTTNPEMPDIDVLFELADLFKVFGDSTRLRIMYTISENEM
                     SVLNIAEALSMEQSTISHQLRVLRQNKLVRVRREGKQIYYSLDDDHVKRIIEMGLDHVL
                     E"
     CDS             4722..7046
                     /locus_tag="ctg25_7"
                     /transl_table=11
                     /translation="MRYKYQLDNLNCAHCAGKIEAKIAETNGFEDVSFNFATKLLNFKS
                     EKQNPVSEIQAICDSIEDGVTVVDKTPKTNLKKYTYTLDNLNCAHCAGKIEAKITETDG
                     FEDVSFNFATKLLNFKSEKQNPVSEIQAICDSIEDGVTVVDKTPKNDITTKAEPKITKK
                     KINRDTIFLAISIVLAVVSEILHLTLDGVTAVHYVVLAACFVATLLSGYKVFIKGAKNI
                     LKLRIDETTLMAVAVIAAFCLGDFVEAAMVTILFSIGEIFEDRAVDASRRDIEKLANIR
                     PDTATIIVDGAEQIVPAESVEIGSIIEVKPYERVPLDGIIIKGKTTLDTSALTGESLPV
                     DAGEGSEVLSGAINGSNLITVKTTKHFGDSTATRILQLVEDAAAQKGNSEKLISRFASV
                     YTPVVVLIAVAIAVIPPLCGLGAFSEWLYRALVCLVASCPCAIVISVPLSYYSGIGAAS
                     EVGVLIKGGKYIEALAKADTFVFDKTGTLTSGKLSVNKVNTVGSYSADEVLALAAASEK
                     YSAHPIASAIREKAIGLELPELSDYSESAGHGTSAVYNGKTIQCGGSKILSDEQKKIAN
                     KDDSVFVIYDGQLIGSLNVSDTVRPEAKEVISQLKALGVKNTVMLTGDRQQPAENVKNE
                     LGLSECHAELLPAQKLELFKGLKSKSKGACFVGDGINDAPVLSASDCGIAMGFGSEAAI
                     EASDAVLASGTLKQLPKAIKIARSVINTVKGNIIFALSIKALVIILAAFGLAQIWMSVI
                     ADTGVSVVCVLIAARLLKKKY"
     CDS             7245..8480
                     /locus_tag="ctg25_8"
                     /transl_table=11
                     /translation="LKKIFLLLVTALFLLSLYGCNTSSSSNNPTEQTTVTNTDDLSLDS
                     DTDSETEFNNDLEIYYNDKKIDNLNLFDALMPTEDGLIYSKINETSPNEIEYYRYYLDK
                     KSSIKLGSIKDWTMQINDKAYVNNHLCFMASTGDITDEENRTLEFIDIDLNKNKMTTVF
                     SDKGGFPYDTITGADNLVIITKVLNNGTSLELYDTETQKFKQLKYLEFDDKNCVGKTIR
                     KVSIDDSTKTICLLVLDCVSETDVSLKIETYDYDMNFLKSYDISDISDDSNELIQGVQF
                     FDFRNNYLIYQNFSMTRCIGYIRDRKLQKSDMIDNIDDTYSMAQTPQKGYNTVLSFKDV
                     DLERNIYLFNTIDKTMKKTKFKPEEENYYIGSMSRTGKDNLMIITTPDNADKKSDLNSR
                     IYFTKLSDLNFQ"
     CDS             8677..10299
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: TPP_enzyme_C"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg25_9"
                     /sec_met_domain="TPP_enzyme_C (E-value: 2.6e-43, bitscore:
                     137.1, seeds: 323, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MISGAEIMVKCLEAEGVDIVFGYPGAAICPFYDKVYDSSITHILV
                     RQEQNAAHAASGYARCSNRPGVCVATSGPGATNLITGIATAYTDSIPIVAITGQVRSDL
                     LGRDVFQEADITGACEPFVKHSYLVSKTEDLPRVFKEAFHIASTGRPGPVLIDIPVDIQ
                     ENEIESFEYPESVNIIGYKPNTKGHAIQVKKAVEAINASKRPVIVSGGGVLSSGIKLKL
                     QKFAETTGIPVISTMMGIGVMPSEHELYLGMLGTHGKAVANRALHEADLVIVCGARLGD
                     RAVAAPDQMSENTKVIHIDIDPAEIGKNVKTEIPIVGDMKNVINMLLDSIGDYKVTTMW
                     SETVKNWKKDLYREPPVFDGFVEPRTLVGHLSAMFRSKAILVADVGQNQIWCANNFRIR
                     EGRFLTTGGMGTMGYSIPAAIGAKFARPDRDVIVICGDGSFQMGLNELATIAGNQLGIK
                     IIIMKNARLGMVRELQDKHYGGRHSATILNGDPDFLKIADAYGIDHAEAHSNKEAENII
                     KGIVDSEKPFILVCDVHPDTPSI"
     CDS             10312..10803
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: ALS_ss_C"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg25_10"
                     /sec_met_domain="ALS_ss_C (E-value: 1.6e-30, bitscore:
                     94.9, seeds: 685, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MQYTLSILVENQAGVLSKISGLFSRRGFNIDSLAVGVTQDPSVSR
                     ITIVANGDEYIVEQLEKQLNKLIPVIKVKRLNEGEFISRELVLIKVHCAASKRAEIVKT
                     VEIMQAKIVDVSPSSVTVEYCECASRINTLVDLLKPYGIREIVRTGTVAIDRGTASVSV
                     "
     CDS             10864..11904
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: IlvC"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) IlvN"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg25_11"
                     /sec_met_domain="IlvN (E-value: 7.3e-84, bitscore: 269.0,
                     seeds: 43, tool: rule-based-clusters)"
                     /sec_met_domain="IlvC (E-value: 5.2e-61, bitscore: 194.9,
                     seeds: 295, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKDYTKNMTAPIYYQSDCNLDLLKGKKIAIIGYGSQGHAHALNLK
                     DSGCDVIIGLYKGSKSWAKAEAQGFKVYTSAEAAKQADIIMILINDEKQAALYKNDIEP
                     NLEAGNMLMFAHGFNIHFGCIKPPKDVDVTMVAPKGPGHTVRSEYQVGKGVPCLVAVEQ
                     DATGQAKDLALAYALGIGGARAGVLETTFRTETETDLFGEQAVLCGGVCALMQAGFETL
                     CDAGYDPRNAYFECIHEMKLIVDLIYQSGFAGMRYSISNTAEYGDYITGPKIITEDTKK
                     AMRKVLSDIQDGTFAKDFLLDMSDAGSQVHFKAMRKIAAEAPAEVFGKEVRKLYSWSDE
                     DKLINN"
     CDS             complement(12314..13735)
                     /locus_tag="ctg25_12"
                     /transl_table=11
                     /translation="KLENVNGGVKISWGKVSGATKYRVYYKGSKGWTRMVDTTSTSYID
                     KDVSSGRNYTYTVRCITSDAKKFTSGYNPTGKSVKYVATPKISKLEVTYDGVKLTWNKV
                     AGAEKYRVYYKDRNGWTKLADTTGTTMLDMNVVSKEFDLSVDDIYYTVRCISKDAKSFT
                     SGYDSKGTPIGNHQDCPEIYSIGAVNNGVEMHWTGDAPKFRVYIKENGSWKRIAETYDN
                     YYVHKGAKSGSNTYTVRGVSKDGKKFTTMFNPTGVTYRYKTSDKTRDAYINYMMNHQSE
                     WMPSLGSNHNLSGVMFLDFDFDGVPELVAQKADSNEYSFHSVVYKFEDGKLKRVGNVND
                     GFAIYYNKTAKKYEVHDLKISLNVDDGYYWSGNSIITYDGENLFANMYSARGVGEESNN
                     NIYYNYFDGNDKNISRAKYNEINLKQFNNCVNAHMFTEFIATGYGDNSVWSENTTAENK
                     QSLLDAYNSFSYEKY"
ORIGIN
        1 ttgcaccgag agcctctttt tctatttcac ttttaatatg tcttaaaaaa attccgtcaa
       61 gcgccatagt aactccgtaa attatttatg atatttaccg tttgatgaaa tttcaaatgc
      121 acggtaaatc tgttcgctta aaatcattct tgccatttgg tgaggaaagg tcattctgct
      181 cattgaaaga cgaacatccg cccgtttttt aaccgattcg tcaagtccgt agctgccgcc
      241 gataataaaa tcaacggtgc tttttccgct tacagacgca ttgtcaatca gctttgaaag
      301 ctcctcactc gacatagact ttccctcaat acacattgca acaacataat ccgaaggcga
      361 aattttttgc atgattcgtt ttccctcaga gaaaataacc tcatcaatct gcgacctatt
      421 cggtatgttg ctcttaatgc gttcttccga aagctcaata atattgaatt tacaaaatgc
      481 ggtcaagcgt tttgcatact ctgcaattgc gtcggtaaaa tatttttcct tgattttgcc
      541 gatacaaatt atgttaatct taatcatatt cctcttgtct gtttaaggtt aaaagatgat
      601 ggcttttgtt gtgcttacac tcggagcaac atcaagcgaa taatcgcttt tgtacttcat
      661 tccgtttgat gtgagcaggt ctacggatgt tgacattgca agcggaacgg tattattttc
      721 ttcgctgaga tggccgagca taagtcttaa agttcccttt tcaacaaggt taacaagttc
      781 ttttgcacat gcctcatttg aaagatgtcc tctgtttgaa aggattctct gctttagcgg
      841 ataaggataa aatccgtttt tgagcatatt gatatcgtga tttgactcaa gcacaacaaa
      901 gtcgctctgc tctgcggcag ttctgacatt gggcaacata acgcccatat cagttgctat
      961 aagtgcggat tttccgtcgg gagcagtaac acggtagcaa cagctttccg ccgcatcgtg
     1021 gggtgtgtca attcgctgaa cacgcatatt gccgattaca acctcgtcag ttataacatc
     1081 tgcatccgtg tttggatcaa gcttattacc tgccctcaaa gcattgagcg taccaaggct
     1141 tgaatacacc ttaaagccgt aacgctttgc aagcacacgc aacgcactgc aatggtcagt
     1201 gtgttcgtga gttataaaaa ccgccccgat actgcccata tcaagtccgt ttgcaagcat
     1261 ggcattttca atctgcttgc atgaacggcc tgcgtcaatc agtacgcctt cacttgccga
     1321 acctatgtag tagctgttcc ccttacttcc gctgaacagc ggtactgctc ttgccaaaac
     1381 aatcaatcct tatctttagt ataacgaata tgataacaca aattttaaaa tttgtaaatt
     1441 atctcacaaa aaagccgttc tcacaaagaa aacggctttg atttctaatt aaattttagt
     1501 caggcaccaa gctcctgctc gttgtctcct gtaaaataca cctttttgat atctgcaccg
     1561 agtgctctga acttttcaac aacatcttca tatccacgct caatgaactg aatattagaa
     1621 atctctgttg taccgttaat ttcaagagcg gcaataatca tagccgcacc tgcacgaagg
     1681 tcggttgcct taacgggagc cgctgtgagc ggaacaccgc cctcaatgat tgcaagtctg
     1741 ccctcaacag aaatctgtgc acccattctg ataagctcgc tgacatactg atagcgatta
     1801 tcccaaacat tctcgttgat gatgcttgtt ccgggaacgc tcataagcaa tgcggcaaac
     1861 tgcggctgac agtctgtcgg gaagccggga tgcggcattg tcttgatgtt acagcgcttg
     1921 agcggagcag atgacgcatc aaccttgaga gcctcatcat attccgtaat cttgacgccc
     1981 atctcacgca gctttgcact gattgattca agatgcttcg gtgtaatatt ctttaccgta
     2041 atacaacctc tggttgcggc ggcggcacac atatatgttc ctgcctcaat ctggtcggga
     2101 ataatcgaat aagtaatgcc gtgaagatac tcaacgccac ggattttgat aacatccgta
     2161 cctgcacctc tgacatccgc tcccattgaa ttaaggaagt tcgcaaggtc aacaatatgc
     2221 ggttctcttg cggcattttc aataatggtc tgtccctttg cctttgatgc ggcaagcata
     2281 atgttcattg ttgcaccaac ggacacaaca tcaaggtaca catgtgtacc gacaaggttg
     2341 tcgcattctg cctctataat cgcaccgtca acaagctgag ttgtcgcacc gagagcctca
     2401 aagcctttaa gatgctggtc aatcggacgc acgccaaagt tacagccgcc cggaagagcc
     2461 accttagcct tgccgtactt gcccaaaagt gcgccgagga gataatatga cgctctcata
     2521 cctcttacaa ggtcggtcac agcattgcat gtgcggattt ttgtaggatc aatatataag
     2581 gacgaacggt tgattcgtct tacattagca cccatctgct gaagaattct gctgataagt
     2641 gatacatcgc tgatgttagg aatattttca atctggcacg gctcatcaca aagaataact
     2701 gccggaataa ttgcaacggc tgcatttttc gcaccgctga ttgtcacttc acccgataat
     2761 ggctttccgc cggtaactac gaacttctcc aattgttaca ccccaattaa tgtgtagaag
     2821 atacttttaa ctaaataagc taaatatctg aaaatgtata tctatatagt gtataagtaa
     2881 aaatcaaaaa ttatacgaat ctaaaaattc ataatgagaa ctaatttgtt acattttatt
     2941 aaaaacgaac ccactcggtt acgcagatgt aatttaacaa ttctcttaca gaaaatgata
     3001 ctacaaaatt gtagtaaagt caacggaata ataaaactgt aatctatttt tgggcaagtt
     3061 gtactcaaat tattaatttg ttgctttttt tgtttttaat ataaccaacc atacttttta
     3121 aaatcgtttt ttcctaaaaa gaagtaatta atcaaagcaa ttttttgtaa aattattaca
     3181 aattgaaaca gttattatat tttcttaatt gaaaatttgc aggcaaatct atcgtatatt
     3241 tattctttgc aaatcaaacg aataaaacaa aaatatttaa aggtaaattt tttaaaaatc
     3301 acagacaaaa tgattattat gccgaaaaaa agactttact gccacttgca ttgaatttaa
     3361 aacttttatc aattatgatt gaaacagaat cagtcggcaa gtgtcctttt acattataat
     3421 aacgacaaaa ttaaggcatt gcggcaaatt tttaattaac gggggattca gaatgagcga
     3481 aacagcaaaa gaaccgaaaa aaataagtaa aagaagcagt gaagaaaaaa ttgaaattat
     3541 tgttgcgatt tttctcggaa taaccgcact cgccacagca tgggcatcgt ggataggttc
     3601 acttcacggc ggaaatcagg cgactaacta cacaaaaagc aacaacctct catcagaggg
     3661 caactcgatg tggaatgagg cttctcaaaa tcttatgcag gatatgatca catggaatga
     3721 catcaatgag gcaaacctta attaccaata tgcggaatct aaaaacgata aagcggaaat
     3781 ggaaaaatat cagtaccaaa ttgatcagct tatgagtgat aactgtacag aagaatttct
     3841 tgaggcaatt aattgggcaa tggatcaaaa ggaaaatgta actccgttta tgaaggacgg
     3901 ttacaccgaa agctattttg cagaggcaaa agctacaatt gaagagtcgg acaaacttct
     3961 tgaacaaggt aagaaagata acgcaaacgg tgacgcattc ggtcttgtaa gcgtaattta
     4021 ctcggttgta ctctttatgc tcggtatcgt aggcacattc aagaatcttc cgaatagaag
     4081 aattgtgctc ggtgttgcag ttgtaggttt tattcttgcc actatatata tgtttacaat
     4141 tccgatgccg acaggattca atattctcag ttatttcgga atggcataaa acaaaatatt
     4201 ctgtactcac agcggtgaaa gcaaatgctt ttgccgctgt ttttttgtaa aaaatcaaaa
     4261 aaatattaca cttttccctc tatgtctatt gactttctaa agagagaatg ctatattata
     4321 attaacatat gagcatatct tcatatgttc aagtataact attaacctga gagaaaatta
     4381 aggggacgcc tatggaaaac aaagaaaaaa caaccaatcc cgaaatgccc gacattgatg
     4441 tgctgtttga gcttgcagac ctttttaagg ttttcggtga ttcaacccga cttcgcatta
     4501 tgtacaccat ttcggaaaat gaaatgtcgg tgctcaacat tgctgaagct ctcagcatgg
     4561 agcaaagcac aatttcccac caactgcgtg tgttaaggca gaacaagctg gtgcgtgttc
     4621 gccgtgaagg aaagcagatt tattacagcc ttgacgatga ccatgtgaaa cgaatcatag
     4681 aaatgggact tgaccatgtt cttgaataag gagggagaca tatgaggtac aaatatcagc
     4741 ttgacaatct caactgcgct cattgtgcag gcaagattga ggctaaaatt gcagaaacaa
     4801 acggctttga ggatgtaagc ttcaattttg cgacaaaact tctcaatttc aaaagcgaaa
     4861 agcagaatcc tgtttccgaa attcaggcaa tttgcgacag cattgaggac ggtgtaaccg
     4921 ttgttgacaa aactccgaaa accaatctca aaaaatacac ctacacttta gacaatctca
     4981 actgcgctca ctgtgcaggc aaaattgagg ctaaaattac agaaacagac ggctttgagg
     5041 atgtaagctt taattttgcg acaaaacttc ttaacttcaa aagcgaaaag cagaatcctg
     5101 tttccgaaat tcaggcaatc tgcgacagca ttgaggacgg tgtaactgtt gttgacaaaa
     5161 ctccgaaaaa tgatatcaca acaaaggcag aacccaaaat cacgaaaaag aaaatcaacc
     5221 gtgacacaat cttccttgca atttcaattg tacttgctgt agtgtccgaa attctccacc
     5281 ttacacttga cggtgttacg gctgttcatt atgttgtact cgcagcgtgt tttgttgcaa
     5341 cacttctttc gggttacaag gtattcatca agggtgcaaa aaacattcta aagctgagaa
     5401 ttgacgaaac aacgcttatg gctgttgcgg taattgcggc attctgtctt ggagattttg
     5461 ttgaggctgc aatggtaaca atcctctttt ctatcggtga aatttttgag gatcgagcag
     5521 ttgacgcatc ccgccgtgac attgaaaagc ttgcaaacat tcgtcccgat acagcaacaa
     5581 ttattgttga cggtgcggaa cagattgttc ctgccgaaag cgttgaaatc ggaagtatca
     5641 ttgaagtcaa gccatacgaa agagttccgc ttgacggcat tattatcaaa ggtaaaacaa
     5701 ctctcgacac atcggctctc acaggcgaaa gccttcctgt tgatgcaggc gagggcagtg
     5761 aggtactcag cggcgcaatc aacggcagta accttattac cgtcaaaacc acaaagcatt
     5821 tcggcgacag taccgcaaca aggattcttc agcttgttga agatgccgcc gctcaaaagg
     5881 gcaacagcga aaagcttatt tcaagatttg cctctgttta cacaccggtt gttgtactca
     5941 ttgcagttgc aatcgcagta attcctccgc tttgcggact cggagcattc agtgaatggc
     6001 tataccgtgc gcttgtttgt cttgtagcgt catgtccgtg tgctattgtt atttccgtac
     6061 ctctctccta ctattcgggt atcggtgcgg catccgaagt cggtgtactc atcaagggcg
     6121 gaaaatatat tgaggctctt gcaaaagcag acacattcgt attcgataaa acaggcacgc
     6181 tcacaagcgg caagctcagc gtaaacaagg ttaatactgt cggttcatac agtgccgacg
     6241 aagttcttgc tcttgccgct gcaagcgaaa aatattccgc tcatccgatt gcctccgcaa
     6301 tcagagaaaa ggcaatcggt cttgaacttc ccgagctttc agactacagt gaaagtgccg
     6361 gtcacggaac aagcgcagtt tataacggca aaactattca gtgcggcggt tcaaagattc
     6421 tttcggacga acagaaaaag attgcaaata aagacgattc tgttttcgta atttatgacg
     6481 gtcagcttat cggttcgctc aatgtcagcg atacggtaag gcctgaggca aaagaggtta
     6541 tctcacagct taaagcgctc ggtgtcaaga acacggtaat gctcacaggt gacagacaac
     6601 agcctgccga aaatgttaaa aacgaactcg gactttccga atgtcacgca gagcttctcc
     6661 ctgctcaaaa gcttgagctt ttcaagggct tgaagtcaaa atccaagggt gcttgctttg
     6721 tgggcgacgg catcaatgat gcccctgttc tttcggcaag cgactgcggt atcgcaatgg
     6781 gattcggcag tgaagccgct attgaagcgt cagacgcagt tctcgcatca ggcacactca
     6841 aacagcttcc aaaggcaatt aaaattgcaa gaagtgttat caacaccgtc aagggcaaca
     6901 tcatctttgc cctctcaatc aaggctcttg taattatcct tgccgcattc ggtcttgcac
     6961 aaatctggat gtctgttatc gctgacacag gcgtcagcgt agtctgcgta ctcatagccg
     7021 caagactcct caaaaagaaa tattgatttt tttgcaaatc atatcattta ttatgataaa
     7081 gcaccgtgag ctttcacaag tttcacggtg ctttcatttg ccaaaatttt tctaaacata
     7141 atcttatatt atagtatttt gaaattattg acttttataa ttatataaat tataatgttt
     7201 ttgtcagcgc ttgtaactga taaataaact tcggagagat taatttgaaa aagatatttt
     7261 tattattagt aaccgcttta tttttacttt cattatacgg gtgtaacact tcttcatcaa
     7321 gcaataaccc cactgaacaa acaaccgtaa cgaatacaga tgatttatct cttgattcag
     7381 atacagattc tgaaacagaa tttaataacg atttggagat ttactataac gataaaaaga
     7441 ttgataattt aaatcttttc gatgcactta tgccaactga ggatggactc atatattcaa
     7501 aaatcaacga aacttctccg aatgaaatag aatactacag atactattta gacaaaaaga
     7561 gcagtataaa actcggctca ataaaagact ggacaatgca aattaacgat aaagcgtatg
     7621 taaataatca cttatgtttt atggcaagca cgggtgacat tacagatgaa gaaaacagaa
     7681 cccttgaatt tattgatata gaccttaata aaaacaaaat gactactgtc ttttctgaca
     7741 aaggcggttt tccctatgat accattacag gtgcagacaa tcttgtcata atcacaaaag
     7801 tattaaacaa cggtacttct ttggaactgt atgacaccga aacgcaaaag tttaaacaac
     7861 tgaaatattt agagtttgat gataagaact gtgtaggaaa aactataaga aaagtttcaa
     7921 ttgacgacag cacaaaaaca atttgccttt tggttttgga ctgtgtttcg gaaacagatg
     7981 tttctttaaa aatagaaacc tatgactatg atatgaattt tctcaaaagc tatgatatat
     8041 ccgatatttc agatgattca aatgaactga ttcaaggagt gcagtttttt gatttcagaa
     8101 acaactacct tatctatcag aattttagta tgacaagatg tataggttac ataagggaca
     8161 ggaaattgca aaaatccgat atgattgaca acattgacga cacctactct atggctcaaa
     8221 ctccacaaaa aggatataat acagttttat catttaaaga tgttgattta gaacggaata
     8281 tatacttatt taataccatt gacaaaacaa tgaaaaaaac aaaattcaaa cctgaagaag
     8341 aaaactacta tatcggctca atgtcaagaa ctggaaaaga taatttgatg ataataacta
     8401 ctcctgataa tgcagacaaa aaaagtgacc ttaattcaag aatatacttt acaaaattaa
     8461 gcgacttaaa ttttcagtaa acaggcggta aaaatcaatt aaaatccatt ttgcaaatta
     8521 tctgtcaaaa tcctgcaaaa aatttaattt atgggcaata ctgctcttta ctttttaagg
     8581 tatttattgt ataattagcg gtaaagtaaa aaggtatatt taatgttaca aaacaccttt
     8641 tgctcacaat aaaaaggata ggagggacaa aacataatga tcagcggtgc tgaaattatg
     8701 gtaaaatgtt tggaagccga gggcgttgac atagtctttg gttatcccgg tgcggctatc
     8761 tgcccatttt acgataaagt ttacgattcg agcattaccc acattcttgt tcgtcaggaa
     8821 cagaacgctg ctcatgcggc aagcggctat gcaagatgca gtaatcgtcc cggtgtttgc
     8881 gtggcaactt ccggtcccgg tgcaaccaac ctcatcacag gcattgcaac cgcctatacg
     8941 gactctattc cgattgttgc cattacaggt caggttcgtt ccgaccttct cggcagagat
     9001 gtctttcagg aagctgacat cacaggagct tgtgaaccgt ttgtaaagca cagttatctc
     9061 gtcagcaaaa cagaagacct tccgagagtt ttcaaagagg ctttccatat tgcctcaacc
     9121 ggcagacccg gtcctgtact tatcgacatt cccgttgata ttcaggaaaa tgaaattgaa
     9181 agttttgaat atcccgaaag cgtaaacatt atcggttaca agccgaacac taagggacat
     9241 gcaattcagg ttaaaaaggc tgttgaggcc atcaacgcaa gcaagcgtcc tgttatcgta
     9301 tcaggcggcg gcgtgctgag ttcgggtatc aagcttaaac ttcaaaaatt tgcagaaact
     9361 acgggtatcc ccgttatttc aactatgatg ggcatcggtg ttatgcccag cgagcatgag
     9421 ctttatctcg gaatgctcgg cactcacggc aaggctgttg ccaaccgtgc tcttcacgaa
     9481 gccgaccttg taatcgtatg cggtgcaaga ctcggtgaca gagctgttgc agctcccgac
     9541 cagatgagtg aaaacacaaa ggtaattcac attgacattg accctgctga aatcggtaag
     9601 aatgttaaaa cagaaattcc gattgtaggc gatatgaaaa atgtcatcaa tatgctgctt
     9661 gacagcatcg gcgattacaa ggttacaaca atgtggagcg aaaccgtaaa gaactggaaa
     9721 aaagaccttt accgtgagcc tcccgttttt gacggctttg ttgagccgag aacacttgtc
     9781 ggtcatctca gtgcaatgtt ccgctcaaag gcaattcttg ttgccgatgt aggacaaaat
     9841 caaatctggt gtgcaaacaa cttccgtatt cgtgagggca gatttctcac aacaggcggt
     9901 atgggtacaa tgggttactc aattcccgct gcaatcggtg caaagtttgc aagacccgac
     9961 cgtgatgtta ttgtaatctg cggtgacggc agttttcaga tggggcttaa tgagcttgcg
    10021 actattgcag gcaatcagct cggaattaaa atcatcatta tgaaaaacgc acgactcgga
    10081 atggttcgtg aacttcagga caaacactac ggcggcagac actccgcaac aattctcaac
    10141 ggtgatcccg acttcttgaa gattgccgat gcttacggca ttgaccatgc agaggctcat
    10201 tcaaacaagg aagccgaaaa catcatcaag ggtattgttg attcggaaaa accgttcatt
    10261 cttgtttgcg atgttcaccc cgacactccg tcaatttaat gaggtgataa aatgcagtat
    10321 acattatcaa tacttgttga aaatcaggcg ggcgttcttt caaaaatttc gggacttttc
    10381 tctcgccgag gttttaacat cgactcactc gcagtaggtg ttactcagga cccgtcggtt
    10441 tcccgaatca caatcgttgc aaacggtgac gagtacattg ttgaacagct tgaaaaacag
    10501 ctcaacaaac tcattcccgt tattaaggta aaaaggctta acgagggcga atttatcagc
    10561 cgtgagcttg tattaatcaa ggttcactgc gccgcctcaa aaagagccga aattgtcaaa
    10621 acggttgaaa ttatgcaagc aaaaatcgtt gatgtatccc cttcgtcagt taccgttgag
    10681 tactgcgaat gtgcaagccg catcaacacg cttgttgact tactcaagcc ttatggtatc
    10741 cgtgagattg taagaacagg tactgttgcc attgacagag gcacagcttc ggtttccgtt
    10801 taatcttaca gttagcatat attttaattt atatgccgcg tttgcggtaa ggaggacttt
    10861 aatatgaaag actacacaaa aaacatgaca gcaccaatct actatcagtc agattgcaac
    10921 cttgaccttc tcaagggtaa gaaaattgct attatcggtt acggcagcca gggtcatgca
    10981 cacgctctca acctcaagga ttcaggttgc gatgtaatca tcggtcttta caaaggcagc
    11041 aagagctggg caaaggctga ggcacagggc tttaaggtat atacatcagc agaggctgca
    11101 aagcaggctg acatcattat gattcttatc aacgatgaaa agcaggcagc tctttacaag
    11161 aacgacatcg agccaaacct cgaagcaggc aatatgctta tgtttgctca cggctttaac
    11221 attcacttcg gttgcatcaa gcctccaaag gatgttgatg ttacaatggt agctcctaag
    11281 ggacctggtc acacagttcg ttcagagtat caggttggta agggtgtacc ttgcctcgtt
    11341 gctgttgagc aggacgctac aggtcaggct aaggatctcg cacttgcata tgcactcggt
    11401 atcggcggtg caagagccgg cgttcttgaa acaacattca gaacagaaac agaaacagac
    11461 ctcttcggtg agcaggctgt tctttgcggc ggtgtttgcg cacttatgca ggcaggtttt
    11521 gaaacacttt gcgatgccgg ttacgaccca agaaacgctt actttgagtg tatccatgag
    11581 atgaagctca tcgttgacct tatctatcag tcaggttttg caggcatgag atattcaatc
    11641 tctaacacag ctgagtacgg tgactacatc acaggtccaa agatcatcac agaggatact
    11701 aagaaggcta tgagaaaggt tctttctgac attcaggacg gtacatttgc taaggacttc
    11761 ctccttgaca tgagcgatgc cggttcacag gttcacttca aggctatgag aaagatcgct
    11821 gccgaagctc ctgccgaagt attcggtaag gaagttagaa agctctacag ctggtctgac
    11881 gaagataagc tcatcaacaa ctaatgtttt ttagttcgtg aagttagttt gatatattca
    11941 agcttctgtc acccgagcat tacatagtac gaatttaggg tagcttgatt ttcaagctac
    12001 cctttttgcg agtgcctcgc tcgtagttcg tgtaggtagt ttgtgataat ttacaactac
    12061 ttattcccga gcttaacata gttataattt tggggtagct tgaatttttt caagctaccc
    12121 tttttgcgag tacctcgccc gcagttcgtg taggtagttt gtgataattt acaactactt
    12181 gttcccaagc attacatagt acagattaac ggttcagtca atttggctga accgtttttt
    12241 gttgttcaat aaaagggttc agctttttac agctgaaccc ttttgcagtt aaaacttatt
    12301 aatttttaaa tattcaatac ttctcatagg agaaagaatt ataagcgtca agcaaagact
    12361 gcttattctc agctgtagta ttctcactcc atacgctgtt atcaccataa cctgttgcaa
    12421 taaattcggt aaacatatgt gcatttacgc aattattaaa ctgtttaagg ttaatttcgt
    12481 tatattttgc ccgtgaaata tttttgtcat taccgtcaaa ataattataa taaatattat
    12541 tatttgattc ttcgcctacg cctcttgccg aatacatatt tgcaaaaaga ttctctccgt
    12601 cgtatgtgat tattgaatta cccgaccaat agtaaccatc atctacattt aaagatatct
    12661 ttaggtcgtg aacctcatac tttttggcag ttttattata gtatatcgca aaaccgtcgt
    12721 taacatttcc cactcttttt aacttaccgt cttcaaattt gtaaacaacg gaatggaaac
    12781 tatactcatt ggaatcagcc ttttgtgcaa caagctccgg aactccgtca aagtcgaaat
    12841 ccaaaaacat aacacctgac aaattgtgat tacttcccaa gcttggcatc cattcactct
    12901 gatgattcat catataattg atataagcgt cccttgtttt atcggatgtc ttatatctgt
    12961 atgttacacc ggttgggtta aacatcgtag taaacttttt accgtctttt gaaacacctc
    13021 ttaccgtata agtgttactg ccggactttg cacccttgtg aacataatag ttgtcataag
    13081 tttctgctat cctcttccaa gaaccgtttt ctttaatata aacacggaac tttggcgcat
    13141 ctcccgtcca atgcatttca acaccgttgt ttactgcacc aatgctgtaa atttcgggac
    13201 aatcctgatg attgccaata ggcgtaccct ttgaatcgta gccgcttgta aaactcttgg
    13261 catccttgct gatacaacga accgtgtaat aaatatcgtc aacgcttaaa tcaaattcct
    13321 ttgaaacaac attcatatca agcatagtcg tgcctgttgt gtcggcaagc tttgtccaac
    13381 cgttcctgtc cttgtagtac acacgatatt tttcagcacc tgcgaccttg ttccatgtca
    13441 gctttacgcc gtcatatgta acctcaagtt ttgaaatttt cggagtggcg acatacttta
    13501 ccgacttgcc tgtcgggtta taaccgcttg tgaatttctt tgcgtcggat gtaatacatc
    13561 taaccgtata ggtgtaattt ctgcccgatg aaacatcctt gtcgatatat gaggttgaag
    13621 ttgtatcaac cattcgtgtc cagcctttac tgcccttgta gtaaactctg tatttagtcg
    13681 caccgcttac tttgccccaa gagattttca caccgccgtt tacattttca agctt
//
