GCA_014863965.1 - 3 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

gnlProkkaPLAHELAB_13 (original name was: gnl|Prokka|PLAHELAB_13)

Region	Type	From	To	Most similar known cluster		Similarity
Region 13.1	ranthipeptide	9,536	30,909

gnlProkkaPLAHELAB_15 (original name was: gnl|Prokka|PLAHELAB_15)

Region	Type	From	To	Most similar known cluster		Similarity
Region 15.1	RRE-containing	1	10,376

gnlProkkaPLAHELAB_23 (original name was: gnl|Prokka|PLAHELAB_23)

Region	Type	From	To	Most similar known cluster		Similarity
Region 23.1	HR-T2PKS,NRPS	22,933	84,670

Region	Type	From	To	Similarity
Region 13.1	ranthipeptide	9,536	30,909
Region 15.1	RRE-containing	1	10,376
Region 23.1	HR-T2PKS,NRPS	22,933	84,670

No secondary metabolite regions were found in these records:: gnlProkkaPLAHELAB_1 (original name was: gnl|Prokka|PLAHELAB_1); gnlProkkaPLAHELAB_2 (original name was: gnl|Prokka|PLAHELAB_2); gnlProkkaPLAHELAB_3 (original name was: gnl|Prokka|PLAHELAB_3); gnlProkkaPLAHELAB_4 (original name was: gnl|Prokka|PLAHELAB_4); gnlProkkaPLAHELAB_5 (original name was: gnl|Prokka|PLAHELAB_5); gnlProkkaPLAHELAB_6 (original name was: gnl|Prokka|PLAHELAB_6); gnlProkkaPLAHELAB_7 (original name was: gnl|Prokka|PLAHELAB_7); gnlProkkaPLAHELAB_8 (original name was: gnl|Prokka|PLAHELAB_8); gnlProkkaPLAHELAB_9 (original name was: gnl|Prokka|PLAHELAB_9); gnlProkkaPLAHELAB_10 (original name was: gnl|Prokka|PLAHELAB_10); gnlProkkaPLAHELAB_11 (original name was: gnl|Prokka|PLAHELAB_11); gnlProkkaPLAHELAB_12 (original name was: gnl|Prokka|PLAHELAB_12); gnlProkkaPLAHELAB_14 (original name was: gnl|Prokka|PLAHELAB_14); gnlProkkaPLAHELAB_16 (original name was: gnl|Prokka|PLAHELAB_16); gnlProkkaPLAHELAB_17 (original name was: gnl|Prokka|PLAHELAB_17); gnlProkkaPLAHELAB_18 (original name was: gnl|Prokka|PLAHELAB_18); gnlProkkaPLAHELAB_19 (original name was: gnl|Prokka|PLAHELAB_19); gnlProkkaPLAHELAB_20 (original name was: gnl|Prokka|PLAHELAB_20); gnlProkkaPLAHELAB_21 (original name was: gnl|Prokka|PLAHELAB_21); gnlProkkaPLAHELAB_22 (original name was: gnl|Prokka|PLAHELAB_22); gnlProkkaPLAHELAB_24 (original name was: gnl|Prokka|PLAHELAB_24); gnlProkkaPLAHELAB_25 (original name was: gnl|Prokka|PLAHELAB_25); gnlProkkaPLAHELAB_26 (original name was: gnl|Prokka|PLAHELAB_26); gnlProkkaPLAHELAB_27 (original name was: gnl|Prokka|PLAHELAB_27); gnlProkkaPLAHELAB_28 (original name was: gnl|Prokka|PLAHELAB_28); gnlProkkaPLAHELAB_29 (original name was: gnl|Prokka|PLAHELAB_29); gnlProkkaPLAHELAB_30 (original name was: gnl|Prokka|PLAHELAB_30); gnlProkkaPLAHELAB_31 (original name was: gnl|Prokka|PLAHELAB_31); gnlProkkaPLAHELAB_32 (original name was: gnl|Prokka|PLAHELAB_32); gnlProkkaPLAHELAB_33 (original name was: gnl|Prokka|PLAHELAB_33); gnlProkkaPLAHELAB_34 (original name was: gnl|Prokka|PLAHELAB_34); gnlProkkaPLAHELAB_35 (original name was: gnl|Prokka|PLAHELAB_35); gnlProkkaPLAHELAB_36 (original name was: gnl|Prokka|PLAHELAB_36); gnlProkkaPLAHELAB_37 (original name was: gnl|Prokka|PLAHELAB_37); gnlProkkaPLAHELAB_38 (original name was: gnl|Prokka|PLAHELAB_38); gnlProkkaPLAHELAB_39 (original name was: gnl|Prokka|PLAHELAB_39); gnlProkkaPLAHELAB_40 (original name was: gnl|Prokka|PLAHELAB_40); gnlProkkaPLAHELAB_41 (original name was: gnl|Prokka|PLAHELAB_41)

Compact view

gnlProkkaPLAHELAB_13 - Region 1 - ranthipeptide

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Location: 9,536 - 30,909 nt. (total: 21,374 nt) Show pHMM detection rules used

Region on contig edge.

ranthipeptide: (TIGR03973 or SCIFF or (cds(PF04055 and (TIGR04085 or SPASM)) and minimum(1, [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE, Cytolysin_C_RRE, Goadsporin_CD_RRE, Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE, Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE, Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE, Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE, Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE, Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE, Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE, Thiaglutamate_B_RRE, Thiaglutamate_G_RRE, Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE, Thurincin_rSAM_RRE, Trifolitoxin_RRE]) and not (TIGR01716 or subtilosin or TIGR02111 or TIGR03966 or TIGR04103 or (YcaO or TIGR03604))))

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

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Gene details

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Gene overview

KnownClusterBlast

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Similar known gene clusters from MIBiG 3.1

No matches found.

gnlProkkaPLAHELAB_15 - Region 1 - RRE-containing

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Location: 1 - 10,376 nt. (total: 10,376 nt) Show pHMM detection rules used

Region on contig edge.

RRE-containing: minimum(1, [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE, Cytolysin_C_RRE, Goadsporin_CD_RRE, Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE, Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE, Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE, Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE, Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE, Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE, Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE, Thiaglutamate_B_RRE, Thiaglutamate_G_RRE, Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE, Thurincin_rSAM_RRE, Trifolitoxin_RRE])

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

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Gene details

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Gene overview

KnownClusterBlast

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Similar known gene clusters from MIBiG 3.1

No matches found.

gnlProkkaPLAHELAB_23 - Region 1 - HR-T2PKS,NRPS

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Location: 22,933 - 84,670 nt. (total: 61,738 nt) Show pHMM detection rules used

HR-T2PKS: (hr-t2pks-ksa and (t2fas or APE_KS2 or ketoacyl-synt))
NRPS: cds(Condensation and (AMP-binding or A-OX))

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

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Gene details

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Gene overview

NRPS/PKS domains

KnownClusterBlast

NRPS/PKS modules

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Detailed domain annotation

Selected features only

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Similar known gene clusters from MIBiG 3.1

No matches found.

Module view

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NRPS/PKS products

NRPS/PKS substrates

Predicted core structure(s)

For candidate cluster 1, location 22932 - 84670:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (Ile - X)

Direct lookup in NORINE database: strict or relaxed

For candidate cluster 2, location 22932 - 65131:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (Ile - X)

Direct lookup in NORINE database: strict or relaxed

For candidate cluster 3, location 37338 - 84670:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (Ile - X)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

ctg23_61

Search NORINE for peptide: strict or relaxed

AMP-binding (457..845): Ile

nrpys: Ile

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: N/A
Small clusters prediction:: Aliphatic, branched hydrophobic (Val, Leu, Ile, Abu, Ival)
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: DASFLGGVYK
Nearest Stachelhaus code(s):: Ile DALFMGGVYK (56% 8Å match)
Stachelhaus code match:: 80% (moderate)

AMP-binding (1479..1869): X

nrpys: Asp, Asn, Glu, Gln, Aad

SVM prediction details:

Predicted physicochemical class:: hydrophilic (Arg, Asp, Glu, Asn, Lys, Gln, Orn, Aad)
Large clusters prediction:: Aliphatic chain with H-bond donor (Asp, Asn, Glu, Gln, Aad)
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: DMKNLGTVSK
Nearest Stachelhaus code(s):: Asp DMKDLGMVDK (53% 8Å match)
Stachelhaus code match:: 70% (weak)